DNV3681's exceptional activity against bioterrorist threats presented at ASM Microbe 2019
24 Juin 2019 - 6:00PM
DNV3681's exceptional activity against
bioterrorist threats presented at ASM Microbe 2019
- Major Steven Zumbrun (USAMRIID1, U.S. Department of Defense)
presented data on the in vitro assessment of DNV3681 against
pathogens classified as "high priority" bioterrorist threats, last
week in San Francisco.
- DNV3681 has demonstrated exceptional activity against Bacillus
anthracis, superior to that of Ciprofloxacin, one of the reference
treatments.
- On the basis of these data, USAMRIID intends to conduct the in
vivo assessment of DNV3681 against Bacillus anthracis, the
bacterium that causes anthrax.
DEINOVE (Euronext Growth Paris : ALDEI), a
French biotech company that uses a disruptive approach to develop
innovative antibiotics and bio-based active ingredients for
cosmetics and nutrition, disclosed the details of the paper
presented last Friday at the ASM Microbe 2019 congress by Major
Steven Zumbrun, PhD in Microbiology at the U.S. Army Medical
Research Institute of Infectious Diseases (USAMRIID).
Major Steven Zumbrun presented the results of
the in vitro evaluation of DNV3681 against Bacillus anthracis and
Francisella tularensis. He concluded that DNV3681 has "exceptional
activity" against these two bio-threat agents. The USAMRIID team
determined the efficacy of DNV3681 by measuring its MIC90, the
minimum concentration necessary to inhibit the growth of 90% of a
panel of test bacterial isolates. This value is 0.015 g/ml against
Bacillus anthracis, making it a more effective molecule than
Ciprofloxacin.
Bacillus anthracis and Francisella
tularensis are classified as two of the most dangerous
possible biological weapons. The standard of care against Bacillus
anthracis and Francisella tularensis is currently Ciprofloxacin, a
synthetic large spectrum antibiotic from the fluoroquinolones’
family. Several pathogenic bacterial species have already developed
a resistance against this family of antibiotics and the long
treatment needed for Post-exposure Prophylaxis of Anthrax very
often triggers a major intestinal microbiota imbalance leading to
likely Clostridioides difficile infections. Therefore, there is an
urgency to make efficient and validated alternatives available. The
fact that the DNV3681 is precisely very active against both
Bacillus anthracis and Clostridioides difficile makes it an ideal
candidate to fulfill that need.
Dr Georges Gaudriault, Scientific
Director of Deinove and co-author of the study, said: "In
addition to its superior in vitro efficacy to current treatments,
the results of the clinical trials that we are currently conducting
for the treatment of Clostridioides difficile infections have shown
that DNV3681 also has the advantage of having a limited impact on
the intestinal microbiota in healthy volunteers, thus limiting the
risks of associated complications. We closely follow the research
conducted by USAMRIID, who is considering, on the basis of the
results presented at ASM Microbe 2019, an in vivo evaluation of our
antibiotic candidate. »
The poster "DNV3681 is a Novel
Quinolonyl-Oxazolidinone Antibacterial with Potent Activity against
Biothreat Pathogens" is available by clicking here.
ABOUT USAMRIID
USAMRIID is celebrating its 50th year of
providing leading edge medical capabilities to deter and defend
against current and emerging biological threat agents. The
Institute is the only laboratory in the Department of Defense
equipped to safely study highly hazardous viruses requiring maximum
containment at Biosafety Level 4. Research conducted at USAMRIID
leads to medical solutions—vaccines, drugs, diagnostics, and
information—that benefit both military personnel and civilians.
Established in 1969, the Institute plays a key role as the lead
military medical research laboratory for the Defense Threat
Reduction Agency’s Joint Science and Technology Office for Chemical
and Biological Defense. USAMRIID is a subordinate laboratory of the
U.S. Army Medical Research and Materiel Command.
For more information, visit
www.usamriid.army.mil.
[The information contained in this press release
does not necessarily reflect the position or the policy of the
Government and no official endorsement should be inferred.]
ABOUT DEINOVE
DEINOVE is a French biotechnology company, a
leader in disruptive innovation, which aims to help meet the
challenges of antibiotic resistance and the transition to a
sustainable production model for the cosmetics and nutrition
industries.
DEINOVE has developed a unique and comprehensive
expertise in the field of rare bacteria that it can decipher,
culture, and optimize to disclose unsuspected possibilities and
induce them to produce biobased molecules with activities of
interest on an industrial scale. To do so, DEINOVE has been
building and documenting since its creation an unparalleled
biodiversity bank that it exploits thanks to a unique technological
platform in Europe.
DEINOVE is organized around two areas of
expertise:
- ANTIBIOTICS, New-generation anti-infective
agents: DEINOVE is preparing to enter a first antibiotic
candidate into Phase II. The Company is also pursuing the
systematic exploration of biodiversity to supply its portfolio with
new leads, drawing notably on partnerships with bioMérieux and
Naicons (AGIR program supported by Bpifrance).
- BIOACTIVES, Active ingredients of natural
origin with cosmetics as the first market and potential in
nutrition and health: DEINOVE already markets a first innovative
active ingredient, a second in partnership with Greentech, while
others are in development with Dow and Oléos (Hallstar Group). It
also runs a program in animal nutrition with Groupe Avril.
Within the Euromedecine science park located in
Montpellier, DEINOVE employs 62 employees, mainly researchers,
engineers, and technicians, and has filed more than 300 patent
applications internationally. The Company has been listed on
EURONEXT GROWTH® since April 2010.
CONTACTS
InvestorsCoralie
MartinMarketing, Communication et Relations
investisseurs Ph. : +33 (0)4 48 19 01
60coralie.martin@deinove.com
MediaALIZE RPAurore
Gangloff Ph.: + 33 (0) 6 49 57 82
68deinove@alizerp.com |
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1 The USAMRIID (U.S. Army Medical Research
Institute of Infectious Diseases) is the U.S. Army’s main
institution and facility for defensive research into
countermeasures against biological warfare.