Neovacs announces in vivo Proof of Concept success for its IL-4 / IL-13 Kinoid a new Therapeutic Vaccine to treat Mite-induc...
07 Novembre 2018 - 5:45PM
PRESS RELEASE
· PRESS RELEASE · PRESS RELEASE
Neovacs announces
in vivo Proof of Concept success
for its IL-4 / IL-13 Kinoid a new Therapeutic Vaccine
to treat Mite-induced Asthma
- IL-4 / IL-13 Kinoid induces
strong production of neutralizing antibodies against cytokines IL-4
and IL-13 and inhibits bronchoconstriction
- These results will help to
define the future development in this indication in order to
provide patients with long-term protection against allergic
diseases.
Paris and Boston,
November 7, 2018 - 5:45 pm CET- Neovacs (Euronext Growth Paris
ALNEV), leader in active immunotherapy for the treatment of
auto-immune and inflammatory diseases, announces today the
successful in vivo proof of concept testing of its IL-4 / IL1-3
Kinoid therapeutic vaccine to treat respiratory allergies, in
collaboration with a research team from the Institut Pasteur.
The IL-4 / IL-13 Kinoid, a
therapeutic vaccine from Neovacs' innovative technology is designed
to target allergic diseases such as asthma and food allergies. The
results obtained in this preclinical study show that the vaccine is
able to inhibit bronchoconstriction, and therefore to restore
breathing capacity.
"These results
establish a very important proof of concept for the strategy of our
therapeutic products platform development based on Kinoid
technology," said Miguel Sieler, CEO of Neovacs. "They validate our ability to produce effective drug
candidates to treat chronic inflammatory diseases such as asthma
which affects more than 300 million people worldwide[1]."
These results were obtained in
collaboration with Dr. Pierre Bruhns and Dr. Laurent Reber's
research team from Antibodies in therapy and Pathology, Inserm Unit
1222, Immunology department at Institut Pasteur:"These results represent an important step in the
development of a long-term treatment against allergies, for which
there is still no effective long lasting solution ", says Dr.
Pierre Bruhns. Dr. Laurent Reber adds: "In this
study we have targeted a decisive pathway to counteract the
developing allergies process, IL-4 / IL-13 Kinoid could potentially
be used to treat many types of allergic conditions."
In July 2018, Neovacs announced
clinical results of its Phase IIb trial with IFNalpha Kinoid
for the treatment of Lupus, validating its innovative approach in
humans, and is pursuing now this clinical development into Phase
III.
The company will continue in
parallel with the next steps of this very promising IL-4 / IL-13
Kinoid program as well as the ongoing preclinical work in type 1
diabetes with IFNalpha Kinoide.
About
Allergies
Allergies are a major public
health problem whose prevalence is steadily increasing, affecting
globally 300 million people suffer from asthma and about 200 to 250
million people suffer from food allergies. One tenth of the
population suffers from drug allergies and 400 million from
rhinitis1. To date,
there is no effective treatment over time for these diseases. The
cytokines IL-4 and IL-13 play a key role in allergic reactions and
therefore represent major therapeutic targets. Most current
treatments for allergies are symptomatic (mainly antihistamines and
corticosteroids). The only therapeutic strategy developed to date
is allergen-specific immunotherapy, which consists of administering
increasing doses of an allergen over several months for
desensitization. However, allergen-specific immunotherapy is
limited by high levels of biomedical adverse reactions and poor
long-term efficacy, particularly for food allergies.
About
Neovacs
Listed on Euronext Growth since 2010, Neovacs is today a leading
biotechnology company focused on an active immunotherapy technology
platform (Kinoids) with applications in autoimmune and/or
inflammatory diseases. On the basis of the company's proprietary
technology for inducing a polyclonal immune response (covered by
four patent families that potentially run until 2032) Neovacs is
focusing its clinical development efforts on IFNalpha Kinoid, an
immunotherapy being developed for the indication of lupus,
dermatomyositis and also in preclinical trial for Type 1 diabetes.
Neovacs is also conducting preclinical development works on other
therapeutic vaccines in the fields of auto-immune diseases,
oncology and allergies. The goal of the Kinoid approach is to
enable patients to have access to safe treatments with efficacy
that is sustained in these life-long diseases. www.neovacs.fr
Contacts
NEOVACS -
Corporate Communication & Investor Relations
Charlène Masson
+33 1 53 10 93 00
cmasson@neovacs.com
NEWCAP-
Media
Annie-Florence Loyer
+33 1 44 71 00 12 / + 33 6 88 20 35 59
afloyer@newcap.fr
Léa Jacquin
+33 1 44 71 20 41 / +33 6 58 14 84 66
ljacquin@newcap.fr
ORPHEON FINANCE -
Financial Communication and Investor Relations
James Palmer
+33 7 60 92 77 74
j.palmer@orpheonfinance.com
[1] Pawankar:
Allergic diseases and asthma: a global public health concern and a
call to action. World Allergy Organization Journal 2014 7:12.
Press release
This
announcement is distributed by West Corporation on behalf of West
Corporation clients.
The issuer of this announcement warrants that they are solely
responsible for the content, accuracy and originality of the
information contained therein.
Source: NEOVACS via Globenewswire
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