Philips and the Spanish National Center for Cardiovascular Research
(CNIC) collaborate on a new ultra-fast cardiac MRI protocol for
research purposes with the aim of benefitting clinical practice in
the future
June 30, 2021
- Ultra-fast, less than one-minute scan time, cardiac MRI enables
accurate assessment of heart anatomy and function, improves patient
comfort, increases access to care, and reduces costs
- Technique can be implemented on existing MRI scanners
- Validated clinical trial results on more than 100 patients with
diverse cardiac pathologies published in leading journal JACC:
Cardiovascular Imaging
Amsterdam, the Netherlands and Madrid, Spain –
Royal Philips (NYSE: PHG, AEX: PHIA), a global leader in health
technology, has participated in an important research project to
develop a magnetic resonance (MR) imaging technique [1,2] that
could potentially revolutionize the use of MR imaging in
cardiology.
Reducing the procedure time for full evaluation of heart anatomy
and function from about one hour down to a few minutes, this new
technique has the potential to increase patient access to precision
diagnosis, improve patient comfort due to shorter scan times, and
lower the cost of care. The technique can be used with existing
phased-array MRI scanners without modification. The results of a
clinical trial to evaluate the technique [2] were published in
April, 2021, in JACC (Journal of the American College of
Cardiology): Cardiovascular Imaging, one of the world's highest
impact journals in the field [3].
“In just over 20 seconds, all the information needed to know the
shape and function of the heart has been acquired. And if you need
to evaluate the degree of fibrosis after cardiac muscle death,
another 20-second acquisition is all it takes, completing the
cardiac study in less than a minute,” said Philips scientist Dr.
Javier Sánchez-González, technical leader of the Philips team that
contributed to the development and leader of the collaboration with
CNIC.
During a conventional MR cardiac examination, patients are
required to lie still inside the bore of the scanner for about one
hour to accurately measure the function of their heart and assess
the extent of damaged heart muscle. It requires multiple complex 2D
and 3D image acquisitions that need to be captured and
reconstructed. As a result, despite being non-invasive and
involving no radiation exposure, MR imaging is still not widely
used for cardiac imaging.
“The main cause is the time needed to do a full study. A
complete study requires about an hour, a period that causes many
patients not to finish the test due to the discomfort it causes
them,” said Dr. Sandra Gómez-Talavera, researcher at the Spanish
National Center for Cardiovascular Research (CNIC), cardiologist at
the Hospital Universitario Fundación Jiménez Díaz (Madrid, Spain),
and co-author of the JACC paper.
The new technique (called ‘Enhanced SENSE by Static Outer-volume
Subtraction (ESSOS)) makes use of the fact that during a
breath-hold, everything within the patient’s chest remains static,
except their beating heart. After an initial image of the static
part (outer volume) has been captured this MRI data is temporarily
removed. The MRI signal of the beating heart can now more easily be
subtracted from subsequent scan data, allowing up to four times
faster acquisition of a 3D image of the heart. This results in a
net acceleration factor of up to 32. Once the dynamic information
of the beating heart is reconstructed, the static outer volume
images are added back to generate a full 3D cardiac image showing
heart anatomy and function, and allowing review from different
views with good image resolution. If needed, a second
contrast-enhanced isotropic 3D single breath-hold scan can reveal
the extent of damage to the patient’s heart muscle.
The results of a clinical trial in which more than 100 patients
with various cardiac pathologies were examined using both the
conventional and the new MR protocol, with the resulting images
being evaluated by expert radiologists, demonstrated excellent
agreement between heart function measurements made using each
technique, as well as excellent agreement in the images to
characterize tissue damage to the patient’s heart muscle [4].
“We have shown in a large group of patients that cardiac MR
imaging using this new technology obtains the same parameters as
the usual technique but reduces the time that a patient has to be
inside the machine by more than 90%,” said Dr. Borja Ibáñez,
Director of the Clinical Research Department of CNIC, Cardiologist
at the University Hospital Fundación Jiménez Díaz, and clinical
leader of the work.
The research project to develop this new cardiac MR protocol was
financed by the Carlos III Institute of Health, through a FIS
technological development project, as well as a Translational
Research Grant from the Spanish Society of Cardiology, the European
Research Council (ERC), and the Community of Madrid.
While the collaboration between CNIC and Philips is currently at
the research stage, the goal is to bring this ultra-fast and easy
cardiac MR technique to clinical settings in the near future and
support the common vision of benefiting more patients. Already
today Philips’ integrated MR solutions offer new levels of
ultra-fast and personalized cardiac MR. Examples include the
company’s exam-shortening Compressed SENSE technology, ultra-fast
early diagnosis of heart failure with Strain–encoded magnetic
resonance imaging (SENC-MRI) and MyoStrain (by Myocardial
Solutions), SmartWorkflow end-to-end workflow solution, and
helium-free scanners. Learn more at MR Cardiac imaging | Philips
Healthcare.
More information on the new magnetic resonance (MR) imaging
technique can be found in this press backgrounder.
[1] ‘Enhanced SENSE by Static Outer-volume Subtraction’
(ESSOS)[2] Device for research applications only. Not for clinical
use. [3] Comparison of the Impact Factors of the Most-Cited
Cardiovascular Journals | Circulation Research (ahajournals.org);
Impact Factor Results Rank JACC Journals Among Top 12
Cardiovascular Journals Worldwide - American College of
Cardiology[4] Gómez-Talavera S, Fernandez-Jimenez R, Fuster V,
Nothnagel ND, Kouwenhoven M, Clemence M, García-Lunar I,
Gómez-Rubín MC, Navarro F, Pérez-Asenjo B, Fernández-Friera L,
Calero MJ, Orejas M, Cabrera JA, Desco M, Pizarro G, Ibáñez B,
Sánchez-González J. (2021). Clinical Validation of a 3-Dimensional
Ultrafast Cardiac Magnetic Resonance Protocol Including Single
Breath-Hold 3-Dimensional Sequences. JACC Cardiovasc Imaging,
doi: 10.1016/j.jcmg.2021.02.03
For further information, please contact:
For Philips:Kathy O’ReillyPhilips Global Press OfficeTel.: +1
978-221-8919E-mail : kathy.oreilly@philips.comTwitter:
@kathyoreilly
For CNIC:Fatima LoisHead of Communications of the CNIC.
flois@cnic.esTel.: +34 6 39 28 24 77E-mail: flois@cnic.es
About Royal PhilipsRoyal Philips (NYSE: PHG,
AEX: PHIA) is a leading health technology company focused on
improving people's health and well-being, and enabling better
outcomes across the health continuum – from healthy living and
prevention, to diagnosis, treatment and home care. Philips
leverages advanced technology and deep clinical and consumer
insights to deliver integrated solutions. Headquartered in the
Netherlands, the company is a leader in diagnostic imaging,
image-guided therapy, patient monitoring and health informatics, as
well as in consumer health and home care. Philips generated 2020
sales of EUR 17.3 billion and employs approximately 77,000
employees with sales and services in more than 100 countries. News
about Philips can be found at www.philips.com/newscenter.
About CNICThe National Center for
Cardiovascular Research (CNIC), led by Dr. Valentín Fuster, has as
its mission to enhance cardiovascular research and its translation
to the patient. The center is financed by a pioneering formula of
public-private collaboration between the Government of Spain,
through the Carlos III Institute of Health, and the Pro CNIC
Foundation that brings together 12 of the most important Spanish
companies.
- Press backgrounder Philips CNIC ultra-fast MR protocol
- Philips MR scanner
- Philips MR scanner
- Ultra Fast 3C CMR protocol
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