TIDMNFX

RNS Number : 4440J

Nuformix PLC

13 December 2022

Nuformix plc

("Nuformix", the "Company" or the "Group")

Half Year Report

13 December 2022: Nuformix plc (LSE: NFX), a pharmaceutical development company targeting unmet medical needs in fibrosis and oncology via drug repurposing, announces its unaudited results for the six months ended 30 September 2022.

Operational highlights (including post-period end)

   --      Initial pre-clinical inhalation studies undertaken with NXP002 demonstrated: 

o the proprietary novel form can be delivered in-vivo by a range of nebulisers at the optimum particle size for delivery to the deep lung;

o very high doses appear to be well-tolerated in the lung; and

o an in-vivo inhalation dose response was observed for both inflammatory and fibrotic biomarkers associated with disease progression.

-- Subsequently, the Company initiated studies in a state-of-the-art 3D human Idiopathic Pulmonary Fibrosis (" IPF") lung tissue, using a disease and species relevant model, which will focus firstly on the anti- inflammatory and anti-fibrotic action of NXP002 in combination with current standards-of-care and secondly investigate duration of action.

-- The Company presented NXP002 for the first time to the global IPF medical and pharmaceutical specialist community at the ERS Congress in Barcelona.

   --    A programme of work to progress NXP004 was initiated: 

o scale-up of lead cocrystal production processes; and

o in-vitro dissolution comparison of lead co-crystals to Lynparza(R) (commercially available olaparib).

-- Oxilio, the licensee of NXP001, is investigating aprepitant for the potential new treatment of cancer indications. Continuing efforts are being made with Quotient Sciences to explore the formulation development options of NXP001 to understand the feasibility of achieving bioavailability and a dosing regime adequate for treatment of this indication. This work, which is contingent on the manufacturing and supply of additional cocrystal material for testing and evaluation, is underway.

   --    Leadership team enhanced with the appointments of: 

o Dr Julian Gilbert as Non-Executive Chairman, who brings significant pharma and biotech business development, corporate development and general leadership experience; and

o Dr Dan Gooding as Executive Director, who is a co-founder of Nuformix and was the Company's CEO until June 2020. He instigated the Company's NXP002 programme as an inhaled therapy for the treatment of IPF and has been acting as a consultant to the Company since March 2022.

Financial Highlights

   --    Loss before tax GBP423,677 (30 September 2021: loss of GBP449,023) 

-- Loss on ordinary activities (after tax credit) of GBP422,514 (30 September 2021: loss of GBP449,023)

   --    Loss per share 0.06p (30 September 2021: 0.08p) 

-- Net assets of GBP4,591,964 (30 September 2021: GBP5,250,968) including GBP389,840 of cash and cash equivalents at 30 September 2022 (30 September 2021: GBP1,071,831)

Dr Dan Gooding, Executive Director of Nuformix, said: "Our pre-clinical efforts to date demonstrate that inhaled treatment of IPF and related fibrotic lung diseases via NXP002 is a viable concept, a concept that it is becoming increasingly validated by clinical data emerging from the public domain. I expect our on-going penultimate pre-clinical studies to conclude that our data and IP support the progression of the programme towards patients for whom I believe NXP002 can address both the side effect and efficacy limitations of existing IPF treatment options. We hope to announce results for both NXP002 and NX004 in the near-term, with work on both programmes underway. Programme progression is being achieved using existing funds thanks to a lean operational model, which will continue to operate until our R&D and targeted partnering activities require further resource. I am excited by our prospects for the remainder of the year and look forward to sharing results as they emerge."

Enquiries:

 
 Nuformix plc 
 Dr Dan Gooding, Executive Director         Via IFC Advisory 
 Stanford Capital Partners Limited 
 Tom Price / Patrick Claridge (Corporate 
  Finance)                                  +44 (0) 20 3650 3650 
 John Howes (Corporate Broking)             +44 (0) 20 3650 3652 
 IFC Advisory Limited 
 Tim Metcalfe                               +44 (0) 20 3934 6630 
  Zach Cohen                                 nuformix@investor-focus.co.uk 
 

About Nuformix

Nuformix is a pharmaceutical development company targeting unmet medical needs in fibrosis and oncology via drug repurposing. The Company aims to use its expertise in discovering, developing and patenting novel drug forms, with improved physical properties, to develop new products in new indications that are, importantly, differentiated from the original (by way of dosage, delivery route or presentation), thus creating new and attractive commercial opportunities. Nuformix has a pipeline of pre-clinical assets with potential for significant value and early licensing opportunities.

Nuformix plc shares are traded on the London Stock Exchange's Official List under the ticker: NFX. For more information, please visit www.nuformix.com .

Chairman's statement

Operational review

NXP002 (new form of tranilast) - Idiopathic Pulmonary Fibrosis (IPF)

NXP002 is the Group's pre-clinical lead asset and a potential novel inhaled treatment for IPF and possibly other fibrosing interstitial lung diseases ("ILDs"). It is a proprietary, new form of the drug tranilast, to be delivered in an inhaled formulation.

IPF is a devastating lung disease associated with a higher mortality rate than many cancers and where there is a need for additional treatment options. Thus, IPF represents a high unmet medical need and a significant commercial opportunity. IPF is classified as a rare disease and presents a global commercial market that is forecast to grow to US$8.8bn by 2027. Sales of standard-of-care therapies OFEV and Esbriet achieved US$2.5bn and US$1bn respectively in 2021.

Tranilast has a long history of safe use as an oral drug for allergies, but there is evidence that supports its potential in fibrosis, including IPF. NXP002 is differentiated as it is a new form of tranilast that is being formulated for delivery direct to the lungs by inhalation, a new route of administration for this drug. The inhalation route is a well-known strategy for treatment of lung diseases to yield greater efficacy and reduce systemic side-effects compared to oral treatment. Nuformix has two patent families protecting new forms of tranilast, some members of which have been granted in major pharmaceutical territories, while others are still in prosecution. In addition, in March 2022 a method of use patent application was filed.

NXP002, as a potential treatment for IPF, is a likely candidate for Orphan Drug Designation which could provide additional product protection against potential competitors. The positioning of such an inhaled treatment for IPF could be either added to standard of care or administered as a monotherapy.

The pre-clinical inhalation strategy, initiated by the Company has significantly progressed NXP002 demonstrating:

   --      it can be delivered in-vivo by a range of nebulisers at the optimum particle size; 
   --      very high doses appear to be well-tolerated; and 

-- an in-vivo inhalation dose response was observed for inflammatory and fibrotic biomarkers that is consistent with previous ex-vivo human IPF tissue studies.

However, the pre-clinical inhalation disease model chosen proved to be complex, and unlike previous studies in human IPF tissue, it continues to be challenging to achieve consistent and reproducible results, which will likely increase in the study of combination therapies, which are now clearly required given the clinical trends intelligence gathered at the ERS. As a consequence, the Company initiated studies in 3D human IPF lung tissue using a disease and species relevant model that is now available commercially via a CRO. Work will focus on NXP002 in combination with current standards-of-care, with the ultimate aim of reducing their negative side effects whilst enhancing their efficacy.

NXP002 combinations have already shown great promise in human diseased IPF tissue, showing a pleasing synergistic efficacy effect with low doses of standards-of-care, resulting in the Group filing a new combination patent application earlier in 2022. The change in pre-clinical strategy , supported by intelligence gathered at ERS, is therefore aligned with and further enhances the Company's overall patent position as it continues to build assets for eventual out-licensing.

The Company presented NXP002 for the first time to the global IPF medical and pharmaceutical specialist community at the ERS Congress in Barcelona. The Company's NXP002 poster sessions were well-attended by, amongst others, potential licensing partners, while the conference confirmed that inhalation is now widely accepted as a future IPF treatment modality.

Overall, the Board is encouraged by the progress of the studies and the positive data generated to date and is considering next steps, including potential further R&D studies to add further value and licensing activities.

NXP004 (novel forms of olaparib) - Oncology

The Group discovered novel forms of olaparib, a drug currently marketed by AstraZeneca, a Lynparza(R). Lynparza(R) was first approved in December 2014 for the treatment of adults with advanced ovarian cancer and deleterious or suspected deleterious germline BRCA mutation. Since then, it has secured similar approvals in breast, pancreatic and prostate cancers with further trials on-going. These approvals have propelled Lynparza(R) sales to US$2.7bn in 2021 with industry analysts forecasting annual sales of US$9.7bn by 2028.

The Group has filed two patent applications on its novel forms of olaparib with the potential for patent life to 2040/2041.

The Company demonstrated enhanced performance of NXP004 cocrystals compared to olaparib. Subsequently, further preformulation studies allowed the Company to identify lead cocrystals to be progressed for further development.

The Company initiated work to progress the NXP004 programme in three key areas:

   --      commence scale-up of lead cocrystal production processes; 

-- compare in-vitro dissolution performance of lead co-crystals to the marketed Lynparza product; and

-- based on the results from these studies a formulation development programme may be initiated. The aims of this work will be to develop prototype formulations that offer the potential to be both bioequivalent and 'bio-better' versus the Lynparza product.

This work will direct and support future out-licensing discussions for NXP004.

NXP001 (new form of aprepitant) - Oncology

NXP001 is a proprietary new form of the drug aprepitant that is currently marketed as a product in the oncology supportive care setting (chemotherapy induced nausea and vomiting). Nuformix granted an exclusive licence to Oxilio Ltd ("Oxilio"), a privately held pharmaceutical development company, to license NXP001 globally for oncology indications on terms previously disclosed. Continuing efforts are being made with Quotient Sciences to explore the formulation development options of NXP001 to understand the feasibility of achieving bioavailability and a dosing regime adequate for treatment of this indication. This work which is contingent on the manufacturing and supply of additional cocrystal material for testing and evaluation is underway.

Board changes

In the period from April 2022 to September 2022 a number of Board changes have occurred:

-- appointment of Dr Julian Gilbert as Non-Executive Chairman, previously a Non-executive Director, replacing Dr Alastair Riddell who resigned in May 2022

-- appointment of Dr Dan Gooding as an Executive Director who is a was a co-founder of Nuformix and the Company's CEO until June 2020

Outlook

The Company to continues to advance and exploit the current assets within the portfolio through the R&D and business development activities as set out above. The sharing agreement with Lanstead provides cash on a monthly basis to the Company to fund its lean operations until the Group's R&D and targeted partnering activities require further resource.

The strategy of the Group is to continue to increase the value of its existing assets while maintaining tight control of costs, including conducting business development/licensing activities using a structured and data-driven approach, with the goal of seeking global licensing deals.

Financial Review

In the first half of the financial year, the Board has continued to focus expenditure on R&D activities that add value to the current assets while optimising the operation to minimise administrative expenditure and the operational cost-base.

Dr Julian Gilbert

Non-Executive Chairman

12 December 2022

Statement of Directors' Responsibilities

We confirm that to the best of our knowledge:

1. this interim condensed set of financial statements has been prepared in accordance with UK adopted IAS 34 'Interim Financial Reporting';

2. the condensed set of financial statements has been prepared in accordance with ASB's 2007 Statement Half-Yearly Reports;

3. the condensed set of financial statements give a true and fair view of the asset, liabilities, financial position and profit or loss of the group and the undertakings included in the consolidation as a whole as required by DTR 4.2.4R; and

   4.    the interim management report includes a fair review of the information required by: 

4.1. DTR 4.2.7R of the Disclosure Guidance and Transparency Rules, being an indication of important events that have occurred during the first six months of the financial year and their impact on the condensed set of financial statements; and a description of the principal risks and uncertainties for the remaining six months of the year; and

4.2. DTR 4.2.8R of the Disclosure Guidance and Transparency Rules, being related party transactions that have taken place in the first six months of the current financial year and that have materially affected the financial position or performance of the entity during that period; and any changes in the related party transactions described in the last annual report that could do so.

The directors of Nuformix plc are listed in the Group's 2022 Annual Report and Accounts and the current board are set out on the Investors Information section of Nuformix's website at: Investors Information - Nuformix

Dr Julian Gilbert

Non-Executive Chairman

12 December 2022

Further copies of this document are available from the company's registered address and will be available on the company's website later today.

Nuformix plc

Registration number: 09632100

Nuformix plc

Registration number: 09632100

Unaudited Interim Results

Consolidated Income Statement and Statement of Comprehensive Income for the six months ended 30 September 2022

 
                                              6 months        6 months 
                                                ending          ending     Year ending 
                                          30 September    30 September        31 March 
                                                  2022            2021            2022 
                                             Unaudited       Unaudited         Audited 
                                  Note             GBP             GBP             GBP 
 Revenue                                             -          50,000          50,000 
 
 Cost of sales                                       -         (1,695)         (1,695) 
                                        --------------  --------------  -------------- 
 
 Gross profit                                        -          48,305          48,305 
 
 Total administrative expenses               (423,677)       (497,327)     (1,318,577) 
 
 Other operating income                              -               -               - 
                                        --------------  --------------  -------------- 
 
 Operating loss                              (423,677)       (449,022)     (1,270,272) 
 
 Finance costs                                       -               -               - 
                                        --------------  --------------  -------------- 
 
 Loss before tax                             (423,677)       (449,022)     (1,270,272) 
 
 Income tax receipt                              1,163               -         161,279 
 
 Loss for the period and total 
  comprehensive income for the 
  period                                     (422,514)       (449,022)     (1,108,993) 
                                        ==============  ==============  ============== 
 
 Loss per share - basic and 
  diluted                           4            0.06p           0.08p           0.19p 
 

Nuformix plc

Registration number: 09632100

Unaudited Interim Results

Consolidated Statement of Financial Position as at 30 September 2022

 
                                           30 September        30 September      31 March 
                                                   2022                2021          2022 
                                  Note        Unaudited           Unaudited       Audited 
                                                    GBP                 GBP           GBP 
 Assets 
 Non-current assets 
 Property, plant and equipment     5                177                 698           438 
 Intangible assets                 6          4,132,182           4,168,640     4,150,411 
                                              4,132,359           4,169,338     4,150,849 
                                        ---------------  ------------------  ------------ 
 Current assets 
 Trade and other receivables                    257,327              53,663       199,600 
 Income tax asset                                     -             121,020       161,279 
 Cash and cash equivalents                      389,840           1,071,831       464,095 
                                                647,167           1,246,514       824,974 
                                        ---------------  ------------------  ------------ 
 
 Total assets                                 4,779,526           5,415,852     4,975,823 
                                        ===============  ==================  ============ 
 
 Equity and liabilities 
 Equity 
 Share capital                     7            709,309             591,609       615,609 
 Share premium                                6,671,253           6,384,835     6,500,817 
 Merger relief reserve                       10,950,000          10,950,000    10,950,000 
 Reverse acquisition reserve                (8,005,195)         (8,005,195)   (8,005,195) 
 Share option reserve                         2,039,044           2,019,681     2,026,664 
 Retained earnings                          (7,772,447)         (6,689,962)   (7,349,933) 
                                        ---------------  ------------------  ------------ 
 
 Total equity                                 4,591,964           5,250,968     4,737,962 
                                        ---------------  ------------------  ------------ 
 
 Current liabilities 
 Trade and other payables                       187,562             164,884       237,861 
                                        ---------------  ------------------  ------------ 
                                                187,562             164,884       237,861 
 
 Total equity and liabilities                 4,779,526           5,415,852     4,975,823 
                                        ===============  ==================  ============ 
 

Nuformix plc

Unaudited Interim Results

Consolidated Statement of Changes in Equity for the six months ended 30 September 2022

 
                    Share        Share        Merger             Reverse            Share            Retained        Total 
                  capital      premium        Relief             acquisition       option            earnings          GBP 
                      GBP          GBP       Reserve             reserve          reserve                 GBP 
                                                 GBP 
 
  At 31 March 
  2021            591,609    6,384,835    10,950,000             (8,005,195)    2,005,952         (6,240,940)    5,686,261 
Loss for the 
 half-year 
 and total 
 comprehensive 
 income                 -            -             -                       -            -           (449,022)    (449,022) 
Share and 
 warrant based 
 payment                -            -             -                       -       13,729                   -       13,729 
                ---------  -----------  ------------  ----------------------  -----------  ------------------  ----------- 
 
  As at 30 
  September 
  2021            591,609    6,384,835    10,950,000             (8,005,195)    2,019,681         (6,689,962)    5,250,968 
Loss for the 
 half-year 
 and total 
 comprehensive 
 loss                   -            -             -                       -            -           (659,971)    (659,971) 
Issue of share 
 capital           24,000      145,982             -                       -            -                   -      169,982 
Share issue 
 costs                  -     (30,000)             -                       -            -                   -     (30,000) 
Share and 
 warrant based 
 payment                -            -             -                       -        6,983                   -        6,983 
                ---------  -----------  ------------  ----------------------  -----------  ------------------  ----------- 
 
  At 31 March 
  2022            615,609    6,500,817    10,950,000             (8,005,195)    2,026,664         (7,349,933)    4,737,962 
Loss for the 
 half-year 
 and total 
 comprehensive 
 income                 -            -             -                       -            -           (422,514)    (422,514) 
Issue of share 
 capital           93,700      170,436             -                       -            -                   -      264,136 
Share and 
 warrant based 
 payment                -            -             -                       -       12,380                   -       12,380 
                ---------  -----------  ------------  ----------------------  -----------  ------------------  ----------- 
 
  As at 30 
  September 
  2022            709,309    6,671,253    10,950,000             (8,005,195)    2,039,044         (7,772,447)    4,591,964 
                =========  ===========  ============  ======================  ===========  ==================  =========== 
 

Nuformix plc

Unaudited Interim Results

Consolidated Statement of Cash Flows for the six months ended 30 September 2022

 
                                                              6 months                6 months 
                                                             ending 30                  ending                    Year 
                                                             September            30 September                   Ended 
                                                                                                              31 March 
                                                                  2022                    2021                    2022 
                                                             Unaudited               Unaudited                 Audited 
                                                                   GBP                     GBP                     GBP 
 Cash flows from operating activities 
 Loss for the year                                           (422,514)               (449,022)             (1,108,993) 
 Adjustments to cash flows from non-cash 
  items 
 Depreciation and amortisation                                  18,489                  18,488                  36,976 
 Income tax expense                                                  -                       -               (161,279) 
 Share and warrant based payment                                12,380                  13,729                  20,712 
                                                             (391,645)               (416,805)             (1,212,584) 
 Working capital adjustments 
 (Increase) decrease in trade and other 
  receivables                                                 (58,888)                (21,403)               (167,340) 
 Increase (decrease) in trade and other 
  payables                                                    (50,300)               (159,740)                (86,763) 
                                          ----------------------------  ----------------------  ---------------------- 
 Cash generated from operations                              (500,833)               (597,948)             (1,466,687) 
 Income taxes (paid)/received                                  162,442                                         121,020 
                                          ----------------------------  ----------------------  ---------------------- 
 Net cash flow from operating activities                     (338,391)               (597,948)             (1,345,667) 
 
 Cash flows from investing activities 
 Net cash flows from investing                                       -                       -                       - 
 activities 
                                          ----------------------------  ----------------------  ---------------------- 
 
 Cash flows from financing activities 
 Proceeds of share issue                                       264,136                       -                 139,982 
 Net cash flows from financing 
  activities                                                   264,136                       -                 139,982 
                                          ----------------------------  ----------------------  ---------------------- 
 
 Net (decrease)/increase in cash and 
  cash 
  equivalents                                                 (74,255)               (597,948)             (1,205,685) 
 
 Cash and cash equivalents at start of 
  period                                                       464,095               1,669,780               1,669,780 
 Cash and cash equivalents at end of 
  period                                                       389,840               1,071,832                 464,095 
                                          ----------------------------  ----------------------  ---------------------- 
 

Nuformix plc Unaudited Interim Results

Notes to the Consolidated Financial Statements for the six month ended 30 September 2022

1. Basis of preparation of interim financial information

The consolidated interim financial statements have been prepared in accordance with the recognition and measurement principles of International Accounting Standards as endorsed by the UK Endorsement Board ("IAS"), and are compliant with IAS34 "Interim Financial Reporting."

The Group prepares its accounts in accordance with applicable UK Adopted International Accounting Standards.

The accounting policies and methods of computation followed in the condensed consolidated interim financial statements are the same as those applied in the most recent annual report

The consolidated interim financial statements are unaudited and do not constitute statutory accounts within the meaning of Section 434 of the Companies Act 2006. Statutory accounts for the year ended 31 March 2022, prepared in accordance with IAS, have been filed with the Registrar of Companies. The Auditors' Report on these accounts was unqualified and included a reference to which the Auditors drew attention by way of an emphasis of matter, without qualifying their report, that a material uncertainty existed that might cast significant doubt on the Group's ability to continue as a going concern at that time. The Auditors' Report did not contain any statements under section 498 of the Companies Act 2006.

The condensed consolidated interim financial statements are for the 6 months to 30 September 2022.

The condensed consolidated interim financial information does not include all the information and disclosures required in the annual financial statements, and should be read in conjunction with the group's annual financial statements for the year ended 31 March 2022, which were prepared in accordance with UK adopted International Accounting Standards ("IFRSs"). As explained above, although this was a different accounting framework, there is no impact on recognition, measurement or disclosure.

2. Basis of consolidation

On 16 October 2017 the Company acquired the entire issued ordinary share capital of Nuformix Technologies Limited and became the legal parent of Nuformix Technologies Limited. The accounting policy adopted by the Directors applies the principles of IFRS 3 (Revised) "Business Combinations" in identifying the accounting parent as Nuformix Technologies Limited and the presentation of the Group consolidated statements of the Company (the legal parent) as a continuation of financial statements of the accounting parent or legal subsidiary (Nuformix Technologies Limited).

3. Going concern

The consolidated interim financial statements have been prepared on the going concern basis of preparation which, inter alia, is based on the directors' reasonable expectation that the Group has adequate resources to continue to operate as a going concern for at least twelve months from the date of their approval. In forming this assessment, the directors have prepared cashflow forecasts covering the period ending 31 March 2024 which take into account the likely run rate on overheads and planned research expenditure and the expectations of a further fundraise to be completed in H1-23.

Whilst there can be no guarantee of the successful outcome of future studies, in compiling the cashflow forecasts the directors have made cautious estimates of the likely outcome of such studies, when a fundraise may complete and have considered alternative strategies should projected funding be delayed or fail to materialise. These strategies include postponing non-committed research expenditure, securing alternative licensing arrangements from those currently planned and additional corporate activity to support the business.

These circumstances indicate the existence of a material uncertainty which may cast significant doubt on the Group's ability to continue as a going concern. The consolidated interim financial statements do not include any adjustments that would result if the company or Group was unable to continue as a going concern.

After careful consideration, the directors consider that they have reasonable grounds to believe that the Group can be regarded as a going concern and, for this reason, they continue to adopt the going concern basis in preparing the consolidated interim financial statements.

4 Loss per Share

Loss per share is calculated by dividing the loss after tax attributable to the equity holders of the Group by the weighted average number of shares in issue during the period.

The basic earnings per share for each comparative period is calculated by dividing the loss in each of those periods by the legal entity's historical weighted average number of shares outstanding.

 
                                      30 September    30 September       31 March 
                                              2022            2021           2022 
                                         Unaudited       Unaudited        Audited 
                                               GBP             GBP            GBP 
Loss after tax                           (422,514)       (449,022)    (1,108,993) 
 
 Weighted average number of shares     707,261,281     591,609,368    598,447,724 
Basic and diluted loss per share             0.06p           0.08p          0.19p 
 
 
5 Property, Plant and Equipment 
                                         Computer equipment 
                                                                     Total 
                                                        GBP            GBP 
Cost or valuation 
At 31 March 2021                                      1,561          1,561 
At 30 September 2021                                  1,561          1,561 
At 31 March 2022                                      1,561          1,561 
                                  -------------------------  ------------- 
At 30 September 2022                                  1,561          1,561 
                                  -------------------------  ------------- 
 
  Depreciation 
At 31 March 2021                                        604            604 
Charge                                                  259            259 
                                  -------------------------  ------------- 
At 30 September 2021                                    863            863 
Charge                                                  260            260 
At 31 March 2022                                      1,123          1,123 
Charge                                                  261            261 
                                  -------------------------  ------------- 
At 30 September 2022                                  1,384          1,384 
                                  -------------------------  ------------- 
 
  Carrying amount 
At 30 September 2021                                    698            698 
                                  =========================  ============= 
At 31 March 2022                                        438            438 
                                  =========================  ============= 
At 30 September 2022                                    177            177 
                                  =========================  ============= 
 
 
6 Intangible Assets 
                                         Goodwill    Patents      Total 
                                              GBP        GBP        GBP 
  Cost 
At 31 March 2021                        4,023,484    449,611  4,473,095 
                                      -----------  ---------  --------- 
At 30 September 2021                    4,023,484    449,611  4,473,095 
Written Off                                     -   (85,035)   (85,035) 
                                      -----------  ---------  --------- 
At 31 March 2022                        4,023,484    364,576  4,388,060 
                                      -----------  ---------  --------- 
At 30 September 2022                    4,023,484    364,576  4,388,060 
                                      ===========  =========  ========= 
 
 

Amortisation

At 31 March 2021 - 286,227 286,227

Amortisation charge - 18,228 18,228

At 30 September 2021 - 304,455 304,455

Amortisation charge - 18,229 18,229

On Written Off - (85,035) (85,035)

At 31 March 2022 - 237,649 237,649

 
Amortisation charge                                 - 18,229 18,229 
At 30 September 2022                              - 255,878 255,878 
Net book value 
At 30 September 2021                    4,023,484 145,156 4,168,640 
At 31 March 2022                        4,023,484 126,927 4,150,411 
At 30 September 2022                    4,023,484 108,698 4,132,182 
 

For impairment testing purposes, management consider the operations of the Group to represent a single cash-generating unit ("CGU") focused on research and development. Consequently, the goodwill is effectively allocated and considered for impairment against the business as a whole being the single CGU.

7 Share Capital

Allotted, called up and fully paid shares

 
                                   30 September                   30 September                                31 March 
                                           2022                           2021                                    2022 
                                      Unaudited                      Unaudited                                 Audited 
                              No.           GBP              No.           GBP              No.                GBP 
                  ---------------  ------------  ---------------  ------------  --------------------  ---------------- 
Ordinary shares 
 of GBP0.001 
 each               709,309,368     709,309        591,609,368     591,609        615,609,368          615,609 
                  ---------------  ------------  ---------------  ------------  --------------------  ---------------- 
 

On 4 April 2022, the company completed a capital increase through the issue of 93,700,000 shares of GBP0.001 each in a share placement at a price of GBP0.015 per share. The Share Premium arising has been calculated in line with the Sharing Agreement with Lanstead Capital Partners LP ("Lanstead") as outlined below.

In December 2021 the Company entered into a Sharing Agreement with Lanstead, split into two tranches of new shares issued with payments to be received over a 20-month period from March 2022 to October 2023.

The agreement is structured in such a way that the proceeds received by the Company are linked to the market price for the Company's shares. The proceeds are calculated based on the volume-weighted average share price in the month preceding the payment from Lanstead, compared to a target price of 2p per share. Based on historic share prices, and a valuation as at the latest available price the total proceeds from Tranche 2 (issued in April 2022) are expected to be GBP264,136 (including Share Premium of GBP170,436), of which GBP206,609 has been recognized in debtors.

8 Share Options and Warrants

The Group operates share-based payments arrangements to remunerate directors and key employees in the form of a share option scheme. Equity-settled share-based payments are measured at fair value (excluding the effect of non-market-based vesting conditions) at the date of grant. The fair value determined at the grant date of the equity-settled, share-based payments and is expensed on a straight-line basis over the vesting period, based on the Group's estimate of shares that will eventually vest and adjusted for the effect of non-market based vesting conditions.

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December 13, 2022 02:00 ET (07:00 GMT)

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