TIDMSHP 
 
FORM 8.3 
 
           PUBLIC OPENING POSITION DISCLOSURE/DEALING DISCLOSURE BY 
 
    A PERSON WITH INTERESTS IN RELEVANT SECURITIES REPRESENTING 1% OR MORE 
 
                  Rule 8.3 of the Takeover Code (the "Code") 
 
1.         KEY INFORMATION 
 
(a) Full name of discloser:                          HBK Investments L.P. on behalf of 
                                                     itself, its subadvisors and its 
                                                     managed funds 
 
(b) Owner or controller of interests and short       N/A 
positions disclosed, if different from 1(a): 
     The naming of nominee or vehicle companies is 
insufficient.  For a trust, the trustee(s), settlor 
and beneficiaries must be named. 
 
(c) Name of offeror/offeree in relation to whose     Shire Plc 
relevant securities this form relates: 
     Use a separate form for each offeror/offeree 
 
(d) If an exempt fund manager connected with an 
offeror/offeree, state this and specify identity of 
offeror/offeree: 
 
(e) Date position held/dealing undertaken:           04 January 2019 
     For an opening position disclosure, state the 
latest practicable date prior to the disclosure 
 
(f)  In addition to the company in 1(c) above, is 
the discloser making disclosures in respect of any   YES: Takeda Pharmaceutical Company 
other party to the offer?                            Limited 
     If it is a cash offer or possible cash offer, 
state "N/A" 
 
2.         POSITIONS OF THE PERSON MAKING THE DISCLOSURE 
 
If there are positions or rights to subscribe to disclose in more than one 
class of relevant securities of the offeror or offeree named in 1(c), copy 
table 2(a) or (b) (as appropriate) for each additional class of relevant 
security. 
 
(a)        Interests and short positions in the relevant securities of the 
offeror or offeree to which the disclosure relates following the dealing (if 
any) 
 
Class of relevant security:                   5p Ordinary (ISIN: JE00B2QKY057) 
                                                  ADR (ISIN: US82481R1068) 
 
                                            Interests               Short positions 
 
                                          Number          %          Number          % 
 
(1) Relevant securities owned and/ 
or controlled:                           2,971,927      0.323                      0.000 
 
(2) Cash-settled derivatives: 
                                        26,543,314      2.891 
 
(3) Stock-settled derivatives 
(including options) and agreements       1,800,000      0.196       1,800,000      0.196 
to purchase/sell: 
 
 
     TOTAL:                             31,315,241      3.410       1,800,000      0.196 
 
All interests and all short positions should be disclosed. 
 
Details of any open stock-settled derivative positions (including traded 
options), or agreements to purchase or sell relevant securities, should be 
given on a Supplemental Form 8 (Open Positions). 
 
(b)        Rights to subscribe for new securities (including directors' and 
other employee options) 
 
Class of relevant security in relation to 
which subscription right exists: 
 
Details, including nature of the rights 
concerned and relevant percentages: 
 
3.         DEALINGS (IF ANY) BY THE PERSON MAKING THE DISCLOSURE 
 
Where there have been dealings in more than one class of relevant securities of 
the offeror or offeree named in 1(c), copy table 3(a), (b), (c) or (d) (as 
appropriate) for each additional class of relevant security dealt in. 
 
The currency of all prices and other monetary amounts should be stated. 
 
(a)        Purchases and sales 
 
  Class of relevant       Purchase/sale     Number of securities     Price per unit 
      security 
 
         ADR                   Buy           464,348 (1,393,044       USD 178.1000 
                                            ordinary equivalent) 
 
(b)        Cash-settled derivative transactions 
 
    Class of        Product         Nature of dealing       Number of    Price per unit 
    relevant      description    e.g. opening/closing a     reference 
    security        e.g. CFD      long/short position,      securities 
                                  increasing/reducing a 
                                   long/short position 
 
 
(c)        Stock-settled derivative transactions (including options) 
 
(i)         Writing, selling, purchasing or varying 
 
Class of   Product     Writing,     Number of   Exercise     Type     Expiry   Option 
relevant description  purchasing, securities to price per    e.g.      date     money 
security  e.g. call    selling,   which option    unit    American,             paid/ 
            option      varying      relates               European           received 
                         etc.                                etc.             per unit 
 
 
(ii)        Exercise 
 
Class of relevant      Product         Exercising/        Number of      Exercise price 
    security         description    exercised against    securities         per unit 
                  e.g. call option 
 
 
(d)        Other dealings (including subscribing for new securities) 
 
 Class of relevant       Nature of dealing             Details        Price per unit (if 
     security            e.g. subscription,                              applicable) 
                             conversion 
 
 
4.         OTHER INFORMATION 
 
(a)        Indemnity and other dealing arrangements 
 
Details of any indemnity or option arrangement, or any agreement or 
understanding, formal or informal, relating to relevant securities which may be 
an inducement to deal or refrain from dealing entered into by the person making 
the disclosure and any party to the offer or any person acting in concert with 
a party to the offer: 
Irrevocable commitments and letters of intent should not be included.  If there 
are no such agreements, arrangements or understandings, state "none" 
 
 
(b)        Agreements, arrangements or understandings relating to options or 
derivatives 
 
Details of any agreement, arrangement or understanding, formal or informal, 
between the person making the disclosure and any other person relating to: 
(i)  the voting rights of any relevant securities under any option; or 
(ii) the voting rights or future acquisition or disposal of any relevant 
securities to which any derivative is referenced: 
If there are no such agreements, arrangements or understandings, state "none" 
 
 
(c)        Attachments 
 
Is a Supplemental Form 8 (Open Positions) attached?                          YES 
 
 
 
Date of disclosure:                         07 January 2019 
 
Contact name:                               Jonathan Brown 
 
Telephone number*:                          +44 (0)20 7659 1906 
 
Public disclosures under Rule 8 of the Code must be made to a Regulatory 
Information Service. 
 
The Panel's Market Surveillance Unit is available for consultation in relation 
to the Code's disclosure requirements on +44 (0)20 7638 0129. 
 
*If the discloser is a natural person, a telephone number does not need to be 
included, provided contact information has been provided to the Panel's Market 
Surveillance Unit. 
 
The Code can be viewed on the Panel's website at www.thetakeoverpanel.org.uk. 
 
SUPPLEMENTAL FORM 8 (OPEN POSITIONS) 
 
    DETAILS OF OPEN STOCK-SETTLED DERIVATIVE (INCLUDING OPTION) POSITIONS, 
                      AGREEMENTS TO PURCHASE OR SELL ETC. 
 
             Note 5(i) on Rule 8 of the Takeover Code (the "Code") 
 
1.         KEY INFORMATION 
 
Full name of person making disclosure:              HBK Investments L.P. on behalf of 
                                                    itself, its subadvisors and its 
                                                    managed funds 
 
Name of offeror/offeree in relation to whose        Shire PLC 
relevant securities the disclosure relates: 
 
2.         STOCK-SETTLED DERIVATIVES (INCLUDING OPTIONS) 
 
 Class of     Product     Written or   Number of    Exercise      Type      Expiry date 
 relevant   description   purchased    securities   price per     e.g. 
 security    e.g. call                  to which      unit      American, 
               option                  option or                European 
                                       derivative                 etc. 
                                        relates 
 
ADR         Call Option  Written      600,000      USD 200     American    18 Jan 2019 
                                      (1,800,000 
                                      ordinary 
                                      equivalent) 
 
ADR         Call Option  Purchased    600,000      USD 185     American    18 Jan 2019 
                                      (1,800,000 
                                      ordinary 
                                      equivalent) 
 
3.         AGREEMENTS TO PURCHASE OR SELL ETC. 
 
Full details should be given so that the nature of the interest or 
position can be fully understood: 
 
 
 
 
 
 
It is not necessary to provide details on a Supplemental Form (Open Positions) 
with regard to cash-settled derivatives. 
 
The currency of all prices and other monetary amounts should be stated. 
 
The Panel's Market Surveillance Unit is available for consultation in relation 
to the Code's disclosure requirements on +44 (0)20 7638 0129. 
 
The Code can be viewed on the Panel's website at www.thetakeoverpanel.org.uk. 
 
 
 
END 
 

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January 07, 2019 09:50 ET (14:50 GMT)

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