false0001636282NONE00016362822023-08-112023-08-11
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
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Date of Report (Date of earliest event reported): August 11, 2023 |
AEGLEA BIOTHERAPEUTICS, INC.
(Exact name of Registrant as Specified in Its Charter)
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Delaware |
001-37722 |
46-4312787 |
(State or Other Jurisdiction of Incorporation) |
(Commission File Number) |
(IRS Employer Identification No.) |
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221 Crescent Street Building 17 Suite 102B |
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Waltham, Massachusetts |
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02453 |
(Address of Principal Executive Offices) |
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(Zip Code) |
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Registrant’s Telephone Number, Including Area Code: 617 651-5940 |
(Former Name or Former Address, if Changed Since Last Report)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
☐Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
☐Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
☐Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
☐Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Securities registered pursuant to Section 12(b) of the Act:
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Title of each class
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Trading Symbol(s) |
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Name of each exchange on which registered
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Common Stock, $0.0001 Par Value Per Share |
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AGLE |
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The Nasdaq Capital Market |
Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).
Emerging growth company ☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐
Item 2.02 Results of Operations and Financial Condition.
On August 11, 2023, Aeglea BioTherapeutics, Inc. (the “Company”) issued a press release announcing its financial results for the quarter ended June 30, 2023. A copy of the press release is furnished as Exhibit 99.1 to this report.
The information in this Item 2.02, including Exhibit 99.1 to this report, shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that section or Sections 11 and 12(a)(2) of the Securities Act of 1933, as amended (the “Securities Act”). The information contained in this Item 2.02 and in the accompanying Exhibit 99.1 shall not be incorporated by reference into any other filing under the Exchange Act or under the Securities Act, except as shall be expressly set forth by specific reference in such filing.
Item 9.01 Financial Statements and Exhibits.
(d) Exhibits
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
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AEGLEA BIOTHERAPEUTICS, INC. |
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Date: |
August 11, 2023 |
By: |
/s/ Jonathan Alspaugh |
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Jonathan Alspaugh President and Chief Financial Officer |
Exhibit 99.1
Aeglea BioTherapeutics Reports Second Quarter 2023 Financial Results
Acquisition of Spyre’s assets and concurrent oversubscribed $210.0 million private investment positions the company to advance a potentially best-in-class inflammatory bowel disease (IBD) portfolio, including and TL1A programs
Sale of legacy pipeline candidate, pegzilarginase, further streamlines operations and increases focus on IBD strategy
$236.7 million of cash and cash equivalents and restricted cash as of June 30, 2023
Waltham, Mass, August 11, 2023 - Aeglea BioTherapeutics, Inc. ("Aeglea" or the "Company") (NASDAQ:AGLE), a biotechnology company advancing a pipeline of antibody therapeutics with the potential to transform the treatment of inflammatory bowel disease ("IBD"), today announced second quarter 2023 financial results and provided program and corporate updates.
“With the acquisition of Spyre Therapeutics and concurrent financing, we are in a privileged position to create meaningful new medicines for patients with IBD and build an industry-leading development organization,” said Cameron Turtle, DPhil, Chief Operating Officer of Aeglea. “Our pipeline of differentiated and potentially best-in-class IBD programs, including 47 and TL1A, combined with a strategy to investigate therapeutic combinations and precision medicine approaches, offers the possibility to transform the treatment of this chronic and debilitating disease.”
“In parallel, we have made significant progress streamlining the organization with the sale of pegzilarginase and pivoting our operations and strategy around the new IBD assets,” said Jonathan Alspaugh, President and Chief Financial Officer of Aeglea. “We are working to rapidly advance our co-lead product candidates with an expectation of initiating clinical studies for both SPY001 and SPY002 in 2024.”
Recent Program and Corporate Updates
Corporate
•Completed the asset acquisition (the "Acquisition") of Spyre Therapeutics, Inc. ("Spyre"), a privately held biotechnology company with a pipeline of antibody therapeutics possessing the potential to transform the treatment of IBD alongside its research partner, Paragon Therapeutics, Inc. ("Paragon").
•Raised $210.0 million in gross proceeds (before deducting approximately $12.7 million in placement fees and other offering expenses) through a sale of Series A non-voting convertible preferred stock (the "Series A Preferred Stock") in a private placement to a group of investors.
IBD Portfolio
With the Acquisition, Aeglea shifted its focus to the development of a potentially best-in-class IBD portfolio including:
•SPY001 – a highly potent and selective anti-α4β7 monoclonal antibody engineered with half-life extension technology and formulated for high concentration, convenient dosing.
oSPY001 is currently progressing through IND-enabling studies and is expected to enter first-in-human (“FIH”) studies in the first half of 2024. Data from a healthy volunteer study are expected by the end of 2024.
•SPY002 – a highly potent and selective anti-TL1A monoclonal antibody engineered with half-life extension technology. TL1A has emerged as one of the most promising targets in IBD and broader immunology indications.
oWe expect to begin FIH studies of the SPY002 program in the second half of 2024 with healthy volunteer data expected in the first half of 2025.
Pegzilarginase
•Sold global rights to pegzilarginase in development for Arginase 1 Deficiency to Immedica Pharma AB ("Immedica") for $15.0 million upfront cash proceeds and up to $100.0 million of contingent milestone payments. The sale of pegzilarginase to Immedica supersedes the previous license agreement between the companies.
oMarketing Authorisation Application for pegzilarginase is under review by the European Medicines Agency.
oThe milestone payments are contingent on formal reimbursement decisions by national authorities in key European markets and pegzilarginase approval by the FDA, among other events.
oNet proceeds of the sale are to be distributed to holders of contingent value rights ("CVR") pursuant to the terms of the CVR Agreement dated July 7, 2023 by and between the Company and a rights agent.
Second Quarter 2023 Financial Results
As of June 30, 2023, Aeglea had available cash and cash equivalents and restricted cash of $236.7 million, including the $210.0 million in gross proceeds from the private placement offering in June 2023.
Aeglea recognized development fee and royalty revenues of $0.7 million in the second quarter of 2023, as a result of its license and supply agreement with Immedica for the commercial rights to pegzilarginase in Europe and several countries in the Middle East. The revenues recorded in the second quarter of 2023 are related to drug supply and royalties from an early access program in France. Aeglea recognized $0.6 million for the second quarter of 2022 in development fee revenues.
Research and development expenses totaled $17.4 million for the second quarter of 2023 and $15.4 million for the second quarter of 2022. The increase was primarily related to restructuring costs net of savings and an increase in reimbursable costs under the Paragon Agreement (as described below).
General and administrative expenses totaled $12.1 million for the second quarter of 2023 and $7.7 million for the second quarter of 2022. This increase was primarily due to restructuring costs, net of savings.
Acquired in-process research and development expenses totaled $130.5 million for the second quarter of 2023 and no expenses for the second quarter of 2022. As the Spyre assets have no alternative use, the net assets acquired are expensed in the period acquired.
Change in the fair value of forward contract liability expense was $58.2 million for the second quarter of 2023 and no expenses for the second quarter of 2022. The stock consideration provided in the Acquisition was not issued until July 7, 2023. Accordingly, the Company recognized a forward contract liability to represent the contractual obligation to issue stock as of June 30, 2023. The increase in expense represents the change in fair value between June 22, 2023 (the Acquisition date) and June 30, 2023 for the redeemable Series A Preferred Stock.
Net loss totaled $217.1 million and $22.3 million for the second quarter of 2023 and 2022, respectively, which includes non-cash stock compensation expense of $1.9 million and $2.0 million for the second quarter of 2023 and 2022, respectively.
About Aeglea BioTherapeutics
In June 2023, Aeglea completed the asset acquisition of Spyre and shifted its disease focus to IBD. Aeglea is advancing a pipeline of antibody therapeutics with the potential to transform the treatment of IBD. The approaches combine novel antibody engineering, rational therapeutic combinations, and precision immunology approaches to maximize efficacy, safety, and convenience of treatments for IBD.
For more information, please visit http://aeglea.com.
Follow Aeglea BioTherapeutics on social media: @aegleabio and LinkedIn.
About the Paragon Agreement
In May 2023, Spyre entered into an antibody discovery option and license agreement with Paragon (the “Paragon Agreement"). As part of the Paragon Agreement, Paragon identifies, evaluates and develops antibodies directed against certain mutually agreed therapeutic targets of interest to the Company. The arrangement currently includes four selected targets: α4β7, TL1A, IL-23, and an undisclosed fourth target. Subsequent to the Acquisition, the Company has exercised its option for the α4β7 program and will be granted an exclusive license to develop, manufacture and commercialize the antibody and products directed to the target, and plans to exercise its option for the other programs upon development candidate selection. From time to time, the Company can choose to add additional targets to the arrangement by mutual agreement with Paragon.
Safe Harbor / Forward Looking Statements
This press release contains "forward-looking" statements within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995. Forward-looking statements can be identified by words such as: "believe," “continue,” "goal," "expect," "may," “intend,” “potential,” "will" and similar references to future periods. These statements are subject to numerous risks and uncertainties that could cause actual results to differ materially from what the Company expects. Examples of forward-looking statements include, among others, statements the Company makes regarding any future payouts under the CVR, its ability to achieve the expected benefits or opportunities and related timing with respect to the Acquisition or to monetize any of its legacy assets, its future results of operations and financial position, its business strategy, its potential growth opportunities, its preclinical and future clinical development activities, the efficacy and safety profile of its product candidates, the potential therapeutic benefits and economic value of its product candidates, and the timing and results of preclinical studies and clinical trials, and other statements that are not historical fact. Actual results may differ materially from those indicated by such forward-looking statements. Factors that could cause actual results to differ include, but are not limited to, risks that the Company may not obtain stockholder approval of the conversion rights of the Series A Preferred Stock, the Company may fail to achieve the expected benefits or opportunities and related timing with respect to the Acquisition or to monetize any of its legacy assets, the Company’s existing cash resources may not be sufficient to fund its future planned operations, the impact of macroeconomic conditions, including inflation, increasing interest rates and volatile market conditions, current or potential bank failures, as well as global events, including the ongoing military conflict in Ukraine and geopolitical tensions in China on the Company's operations, and the receipt and timing of potential regulatory designations, approvals and commercialization of product candidates. Additional risks and uncertainties regarding the Company’s business can be found in the section titled “Risk Factors” in the Company’s Quarterly Report on Form 10-Q for the quarter ended June 30, 2023 filed with the United States Securities and Exchange Commission (“SEC”), and future filings and reports that the Company makes from time to time with the SEC. The information contained in this press release is as of the date of this release, and the Company undertakes no duty to update forward-looking statements contained in this press release except as required by applicable laws.
Contact Information:
Media Contact
Amanda Sellers, Verge Scientific Communications
amanda.sellers@vergescientific.com
Investor Contact
investors@aeglea.com
Aeglea BioTherapeutics, Inc.
Condensed Consolidated Balance Sheets
(Unaudited, in thousands, except share and per share amounts)
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June 30, |
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December 31, |
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2023 |
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2022 |
ASSETS |
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CURRENT ASSETS |
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Cash and cash equivalents |
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$ 235,358 |
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$ 34,863 |
Marketable securities |
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— |
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20,848 |
Development receivables |
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1,646 |
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375 |
Prepaid expenses and other current assets |
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2,882 |
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6,172 |
Total current assets |
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239,886 |
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62,258 |
Restricted cash |
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1,317 |
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1,553 |
Property and equipment, net |
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— |
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3,220 |
Operating lease right-of-use assets |
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2,316 |
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3,430 |
Other non-current assets |
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10 |
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683 |
TOTAL ASSETS |
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$ 243,529 |
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$ 71,144 |
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LIABILITIES AND STOCKHOLDERS’ EQUITY |
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CURRENT LIABILITIES |
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Accounts payable |
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$ 2,854 |
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$ 677 |
Forward contract liability |
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164,382 |
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— |
CVR liability |
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10,500 |
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— |
Operating lease liabilities |
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4,331 |
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625 |
Deferred revenue |
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930 |
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517 |
Accrued and other current liabilities |
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28,427 |
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12,837 |
Related party accounts payable |
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20,810 |
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— |
Total current liabilities |
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232,234 |
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14,656 |
Non-current CVR liability |
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19,000 |
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— |
Non-current operating lease liabilities |
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— |
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4,004 |
Deferred revenue, net of current portion |
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2,341 |
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2,179 |
TOTAL LIABILITIES |
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253,575 |
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20,839 |
Commitments and Contingencies (Note 11) |
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Series A non-voting convertible preferred stock, $0.0001 par value; 1,086,341 and no shares authorized as of June 30, 2023 and December 31, 2022, respectively; 721,452 and no shares issued and outstanding as of June 30, 2023 and December 31, 2022, respectively |
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197,323 |
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— |
STOCKHOLDERS’ (DEFICIT) EQUITY |
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Preferred stock, $0.0001 par value; 8,913,659 shares and 10,000,000 authorized as of June 30, 2023 and December 31, 2022; no shares issued and outstanding as of June 30, 2023 and December 31, 2022 |
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— |
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— |
Common stock, $0.0001 par value; 500,000,000 shares authorized as of June 30, 2023 and December 31, 2022; 81,001,676 shares and 65,350,343 shares issued and outstanding as of June 30, 2023 and December 31, 2022, respectively |
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6 |
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6 |
Additional paid-in capital |
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453,741 |
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475,971 |
Accumulated other comprehensive income (loss) |
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11 |
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(48) |
Accumulated deficit |
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(661,127) |
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(425,624) |
TOTAL STOCKHOLDERS’ (DEFICIT) EQUITY |
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(207,369) |
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50,305 |
TOTAL LIABILITIES, CONVERTIBLE PREFERRED STOCK AND STOCKHOLDERS’ (DEFICIT) EQUITY |
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$ 243,529 |
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$ 71,144 |
Aeglea BioTherapeutics, Inc.
Condensed Consolidated Statements of Operations
(Unaudited, in thousands, except share and per share amounts)
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Three Months Ended |
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Six Months Ended |
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June 30, |
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June 30, |
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2023 |
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2022 |
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2023 |
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2022 |
Revenue: |
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Development fee and royalty |
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$ 688 |
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$ 625 |
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$ 886 |
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$ 1,987 |
Total revenue |
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688 |
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625 |
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886 |
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1,987 |
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Operating expenses: |
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Research and development |
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17,386 |
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15,373 |
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31,162 |
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32,351 |
General and administrative |
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12,062 |
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7,675 |
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17,290 |
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16,500 |
Acquired in-process research and development |
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130,486 |
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— |
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130,486 |
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— |
Total operating expenses |
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159,934 |
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23,048 |
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178,938 |
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48,851 |
Loss from operations |
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(159,246) |
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(22,423) |
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(178,052) |
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(46,864) |
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Other income (expense): |
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Interest income |
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350 |
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104 |
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770 |
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139 |
Change in fair value of forward contract liability |
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(58,170) |
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— |
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(58,170) |
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— |
Other income (expense), net |
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(8) |
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5 |
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(80) |
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1 |
Total other (expense) income |
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(57,828) |
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109 |
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(57,480) |
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140 |
Loss before income tax expense |
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(217,074) |
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(22,314) |
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(235,532) |
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(46,724) |
Income tax (expense) benefit |
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(7) |
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(9) |
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29 |
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(35) |
Net loss |
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$ (217,081) |
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$ (22,323) |
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$ (235,503) |
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$ (46,759) |
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Net loss per share, basic and diluted |
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$ (2.27) |
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$ (0.27) |
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$ (2.48) |
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$ (0.63) |
Weighted-average common shares outstanding, basic and diluted |
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95,565,118 |
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82,209,032 |
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94,917,487 |
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73,650,146 |
v3.23.2
Document And Entity Information
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Aug. 11, 2023 |
Cover [Abstract] |
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8-K
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Document Period End Date |
Aug. 11, 2023
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AEGLEA BIOTHERAPEUTICS, INC.
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0001636282
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Securities Act File Number |
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DE
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Entity Tax Identification Number |
46-4312787
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Entity Address, Address Line One |
221 Crescent Street
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Entity Address, Address Line Two |
Building 17
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Entity Address, Address Line Three |
Suite 102B
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Waltham
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MA
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02453
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651-5940
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Aeglea BioTherapeutics (NASDAQ:AGLE)
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