Pharmaceutical company AbbVie Inc. sold $16.7 billion in new bonds on Tuesday, becoming the latest company to tap the bond market in a big way to help finance an acquisition.

The sale from the North Chicago, Ill.-based company is one of the largest corporate bond deals of the year. AbbVie plans to use the proceeds to pay for its $21 billion acquisition of drug company Pharmacyclics Inc.

The sale, which according to investors attracted $65 billion or more in orders, comes on the heels of a $21 billion sale from Actavis PLC and a $17.5 billion deal from AT&T Inc. earlier this year. Those companies also planned to use the proceeds for acquisitions.

Investors looking for higher interest rates than those available on safe government debt are piling into the large corporate bond sales. The low-rate environment is also driving down the cost of debt for companies, making it a good time for them to sell bonds.

"All these big deals get well oversubscribed," said Zachary Chavis, a portfolio manager at Sage Advisory Services, which oversees about $11 billion and put in an order for the AbbVie bonds. Mr. Chavis said AbbVie's acquisition helps the company diversify away from its blockbuster arthritis drug Humira.

AbbVie sold the bonds in six parts, with bonds maturing between three and 30 years. A 10-year bond was offered to yield 1.45 percentage points more than similar-maturity Treasurys, for a yield of 3.621%.

Despite investor demand, the wave of large corporate-debt sales has weighed on the market. So far in May, U.S. investment-grade corporate bonds have posted a total return of negative 0.66%, reflecting price changes and interest payments, according to Barclays data. For the full year, the total return is a positive 0.93%.

"As long as rates stay at this level, it's really attractive for companies to come out and tap the bond market," said Kent White, director of investment-grade research at Thrivent Asset Management, which oversees $96 billion. Still, Mr. White said he would be "really surprised if we continue to see this level of the really large transactions."

Mr. White said his firm put in an order for the AbbVie bonds. He said he is positive on the U.S. economy for the rest of the year, which should help bolster corporate balance sheets.

Write to Mike Cherney at mike.cherney@wsj.com

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