SMFRW Sema4 Holdings Corporation

Sema4 (Nasdaq: SMFR), an AI-driven genomic and clinical data intelligence platform company, today announced that company management will participate at the following virtual investor conferences:

• Stifel 2021 Virtual Healthcare ConferenceFormal presentation and 1x1s on Tuesday, November 16th, 2021 at 2:40 p.m. ET

• Canaccord Genuity Virtual MedTech, Diagnostics, and Digital Health & Services ForumFireside chat and 1x1s on Thursday, November 18th, 2021 at 11:30 a.m. ET

• Jefferies London Healthcare Conference1x1s on Friday, November 19th, 2021

Live and archived webcasts of the Stifel and Canaccord presentations will be available on the “Events” section of the Sema4 investor relations website at https://ir.sema4.com/.

About Sema4

Sema4 is a patient-centered health intelligence company dedicated to advancing healthcare through data-driven insights. Sema4 is transforming healthcare by applying AI and machine learning to multidimensional, longitudinal clinical and genomic data to build dynamic models of human health and defining optimal, individualized health trajectories. Centrellis®, our innovative health intelligence platform, is enabling us to generate a more complete understanding of disease and wellness and to provide science-driven solutions to the most pressing medical needs. Sema4 believes that patients should be treated as partners, and that data should be shared for the benefit of all.

For more information, please visit sema4.com and connect with Sema4 on Twitter, LinkedIn, Facebook and YouTube.

Investor Relations Contact:Joel KaufmanSema4investors@sema4.com

Media Contact:Radley MossSema4radley.moss@sema4.com