--Zoetis notches big stock-trading gains in IPO

--Former Pfizer animal-health unit is world's biggest player by revenue

--Zoetis CEO says stable industry, emering-market demand will stoke future growth

(Adds details on Zoetis, Pfizer, sector rivals and historical comparison throughout.)

   By Chris Dieterich and Peter Loftus 
 

NEW YORK--Investors eager to invest in the future of animal medicine sent stock in Zoetis Inc. (ZTS), formerly a unit of Pfizer Inc. (PFE), soaring Friday.

Shares jumped 20% as the biggest initial public offering for a U.S. company since Facebook Inc. (FB) hit the market in May.

"This industry shows steady and predictable growth," said Zoetis Chief Executive Juan Ramon Alaix, adding that Zoetis's global reach will allow it to capitalize on opportunities in emerging markets.

Zoetis, of Madison, N.J., is the largest animal-medicine company in the world by revenue. It makes vaccines and drugs for livestock and pets.

Mr. Alaix said investors recognize that Zoetis has the leading share of an estimated $22 billion global animal-health market that is expected to grow about 5.7% annually for the next five years.

Zoetis's shares climbed $5.15, or 20%, to $31.16 in first-day trading. The company's $2.2 billion offering priced shares at $26 late Thursday, above the $22-to-$25 range initially outlined in documents filed with the Securities and Exchange Commission. Zoetis commands a market value of about $15.7 billion based on Friday's opening stock price.

Analysts said Zoetis makes an attractive investment in part because animal-drug research and development tends to be less cost-intensive than that of human medicine development. Animal health tends to rely on broad array of smaller drugs rather than costly, blockbuster drugs that take can years to develop, according to Kevin Kedra, a health-care analyst at Gabelli & Co. in Rye, N.Y.

"The appeal of this stock is that animal health is a fairly stable market, as opposed to the up-and-down nature of human health, which is very much based on patents. This is a much more consistent, stable business," Mr. Kedra said.

Pfizer, the world's largest drug maker by sales, has been shedding businesses outside its core medicine franchise to focus on developing prescription medicines to replace aging products such as cholesterol drug Lipitor, which now faces generic competition. Last year, Pfizer sold its infant-nutrition business to Nestle SA (NSRGY, NESN.VX).

Zoetis reported revenue of $3.2 billion for the first nine months of last year, or about 7% of Pfizer's $43.9 billion in overall revenue during that period. Zoetis's revenue increased 1.7% over that time, while earnings rose 87% to $446 million. Revenue from livestock represents the bulk of its sales.

Pfizer will retain a roughly 80% stake of Zoetis after the offering, and current Pfizer shareholders must go into the open market to buy Zoetis shares. Pfizer executives said last year the company might consider shedding its post-IPO stake in Zoetis by allowing Pfizer shareholders to exchange shares for Zoetis. A Pfizer spokeswoman said Friday the company has several alternatives that are distributing remaining shares. It will make that decision in the future based on "what delivers the best after-tax return for our shareholders," the spokeswoman said.

The company competes primarily with the animal-health segments of other major drug companies, including Merck & Co. (MRK), Sanofi SA (SNY, SAN.FR) and Eli Lilly & Co. (LLY).

The deal is the largest IPO from a U.S. company since Facebook's $16 billion deal May 18. It is also the largest so-called carve-out to list on a U.S. exchange since U.K. hedge-fund manager Man Group PLC (MNGPY, EMG.LN) broke away from MF Global Ltd., which was its brokerage arm, in a $2.9 billion deal in 2007, according to Dealogic.

J.P. Morgan Chase & Co. (JPM), Bank of America Corp. (BAC) and Morgan Stanley (MS) served as Zoetis's lead underwriters.

Write to Chris Dieterich at christopher.dieterich@dowjones.com and Peter Loftus at peter.loftus@dowjones.com

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