CTBO Cantabio Pharmaceuticals Inc (CE)

The date of this information statement is ___________ ___, 2019.

By Order of the Board of Directors,

___________________________________

CANTABIO PHARMACEUTICALS INC.

2225 East Bayshore Road

Palo Alto, California 94303

Tel. 844-200-2826

NOTICE OF ACTION TAKEN BY WRITTEN CONSENT OF

STOCKHOLDERS OF CANTABIO PHARMACEUTICALS INC.

NOTICE IS HEREBY GIVEN, pursuant to Section 228(e) of the Delaware General Corporation Law, that on March 19, 2019, the record holders of a majority of the outstanding shares of common stock acted by a written consent, without a stockholders' meeting, to, among other things, adopt and approve an amendment to Cantabio's certificate of incorporation to effect a 1-for-5,000 reverse stock split of Cantabio's common stock. The following actions will be taken pursuant to the written consent:

1.

On or about the 20 ^th day following the mailing of this information statement, our certificate of incorporation will be amended to effect a 1-for-5,000 reverse stock split of Cantabio's common stock by the filing of the certificate of amendment to Cantabio's certificate of incorporation in substantially the form attached hereto as Appendix A .

2.

On or about the 20 ^th day following the mailing of this information statement, Broadridge Financial Solutions, Inc. will process a reverse stock split of Cantabio's common stock at the rate of 1-for-5,000, whereby every 5,000 shares of Cantabio's existing common stock will be combined and converted into one share of new Cantabio common stock. No fractional shares will be issued, and:

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Stockholders who hold less than 5,000shares of existing common stock on the effective date of the reverse stock split will receive cash in the amount of $0.01296 per share of existing pre-reverse split common stock.

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Stockholders who hold more than 5,000 shares of existing common stock on the effective date of the reverse stock split will receive:

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one share of new common stock for each 5,000 shares of existing common stock held on the effective date of the reverse split; and

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cash in lieu of any fractional share of new common stock that such holder would otherwise be entitled to receive on the basis of $0.01296 per share of existing common stock.

3.

All stock certificates evidencing ownership of Cantabio common stock outstanding immediately prior to the reverse stock split will be deemed for all purposes to represent (a) a claim for cash payment in lieu of a fractional share of new Cantabio common stock and/or (b) new certificates representing the number of shares of new Cantabio common stock that will result from the reverse stock split, whether or not the certificates representing existing Cantabio common stock are surrendered for exchange.

These items are described in detail in the enclosed information statement, which is incorporated by reference and made part of this notice.

By Order of the Board of Directors,

____________________________________

Gergely Toth

Chairman of the Board and Chief Executive Officer

SUMMARY TERM SHEET

The following summary term sheet provides an overview of the material matters that are presented in this information statement. This summary term sheet should be read in conjunction with the full text of this information statement and the appendices attached hereto. EACH STOCKHOLDER IS URGED TO READ THE ENTIRE INFORMATION STATEMENT AND APPENDICES WITH CARE. In this information statement, the terms " Cantabio," "we," "us," "our," and similar terms refer to Cantabio Pharmaceuticals Inc., a Delaware corporation, having its principal executive offices at 2225 East Bayshore Road, Palo Alto, California, 94303, telephone: 844-200-2826. This information statement is first being sent or delivered to Cantabio's stockholders on or about __________ ___, 2019.

The Reverse Stock Split

On or about the 20 ^th day following the mailing of this information statement, Cantabio Pharmaceuticals Inc., a Delaware corporation ("Cantabio"), will file with the Delaware Secretary of State a certificate of amendment to Cantabio's certificate of incorporation to effect a 1-for-5,000 reverse stock split of Cantabio's common stock, par value $0.001, as unanimously approved by our board of directors and the holders of a majority of Cantabio's outstanding shares of common stock. A copy of the certificate of amendment is attached hereto as Appendix A .

Each holder of record on the date of effectiveness of the filing of the certificate of amendment with the Delaware Secretary of State will be entitled to receive one share of new common stock for every five thousand shares of existing common stock held by that person.

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No fractional shares will be issued in connection with the reverse stock split.

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Stockholders who hold less than 5,000 shares of existing common stock on the effective date of the reverse stock split will receive cash in the amount of $0.01296 per share of existing pre-reverse split common stock and will cease to be stockholders of Cantabio after the reverse stock split. The amount of cash each holder of fractional common stock will receive will be calculated by multiplying the number of shares of existing common stock held by the stockholder on the effective date of the reverse stock split times $0.01296.

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Stockholders who hold more than 5,000 shares of existing common stock on the effective date of the reverse stock split will receive:

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one share of new common stock for each 5,000 shares of existing common stock held on the effective date of the reverse split; and

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cash in lieu of any fractional share of new common stock that such holder would otherwise be entitled to receive on the basis of $0.01296 per share of existing common stock. For detailed information concerning the terms and provisions of the reverse stock split, see "Special Factors" and "The Reverse Stock Split."

Effect of the Reverse Stock Split on Cantabio's Existing Common Stockholders

Cantabio currently has 112,724,148 shares of common stock issued and outstanding.  As of December 14, 2018, we had identified 1,839 non-objecting beneficial owners of our common stock. Of these,

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1,552 stockholders currently hold less than 5,000 shares of common stock; and

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287 stockholders currently hold more than 5,000 shares of common stock.

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Based on the aggregate number of stockholders of record of our common stock, and the number of stockholders of more than 5,000 shares of our common stock, we estimate that, following the reverse stock split, there will be approximately 21,359 shares of new common stock issued and outstanding held by approximately 339 shareholders. For additional information concerning the effect of the reverse stock split on our stockholders, see “Special Factors-Effects of the Reverse Stock Split on Unaffiliated Stockholders Who Hold Fewer than 5,000 Shares of Our Common Stock in a Single Account,” “Special Factors-Effects of the Reverse Stock Split on Unaffiliated Stockholders Who Hold 5,000 or More Shares of Our Common Stock in a Single Account,” “Special Factors-Effects of the Reverse Stock Split on Affiliated Stockholders,” “Special Factors-Effects of the Reverse Stock Split on Our Affiliates’ Interests in Our Net Book Value and Net Loss” and “Special Factors-General Examples of Potential Effects of the Reverse Stock Split”

Termination of Cantabio’s SEC Reporting Obligations After the Reverse Stock Split

Following the completion of the reverse stock split and the filing of a Form 15 with the Securities and Exchange Commission, or the SEC, the registration of our common stock, as well as our duty to file reports with the SEC under Sections 13(a) and 15(d) of the Securities Exchange Act of 1934, as amended, will terminate and our common stock will no longer be publicly-traded on the OTCQB bulletin board. We will continue operations as a non-reporting private corporation. Our duty to file reports with the SEC under Sections 13(a) and 15(d) of the Securities Exchange Act of 1934, as amended, is sometimes referred to herein as the “registration and periodic reporting obligations.” For detailed information concerning the purpose, reasons for and effect of the reverse stock split, see “Special Factors.”

Interests of Our Directors and Executive Officers in the Reverse Stock Split

Our board of directors and our executive officers may have interests in the reverse stock split that are or may be different from, or in addition to, your interests as one of our stockholders:

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Each of our directors and our executive officers currently own more than 5,000 shares of common stock and, therefore, expect to continue as stockholders of Cantabio after the implementation of the reverse stock split.

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Unlike stockholders who own less than 5,000 shares of Cantabio common stock on the effective date of the reverse stock split, each of our directors and our executive officers will have the opportunity to participate in the potential upside of any increase in the value of our common stock after the reverse stock split.

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We expect each of our directors and our executive officers to retain their respective current positions as directors or executive officers of Cantabio following the reverse stock split.

Each of our directors and our executive officers will receive the same cash consideration as our unaffiliated stockholders for fractional shares of common stock to which they would be entitled as a result of the reverse stock split. For detailed information concerning the interests of our directors and our executive officers in the reverse stock split, see “Special Factors - Interests of Our Directors and Executive Officers in the Reverse Stock Split.”

Reports, Opinions and Appraisals

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Our board of directors has obtained a report from Albeck Financial Services, an outside financial advisor, as to the fairness of the consideration to be received by holders of common stock who would otherwise hold fractional shares immediately following the reverse stock split. For additional information, see “Special Factors-Factors Considered by Our Board of Directors as to the Fairness of the Reverse Stock Split-Procedural Factors Disfavoring the Reverse Stock Split” and “Special Factors - Reports, Opinions and Appraisals”

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Cantabio has not required the approval of the reverse stock split by the holders of a majority of Cantabio’s shares held by persons unaffiliated with Cantabio. For additional information, see “Special Factors-Factors Considered by Our Board of Directors as to the Fairness of the Reverse Stock Split-Procedural Factors Disfavoring the Reverse Stock Split.”

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Cantabio has not appointed a special committee of independent directors or other unaffiliated persons to determine the fairness of the terms of the reverse stock split. For additional information concerning the appointment of a special committee, see “Special Factors-Factors Considered by the Board of Directors as to the Fairness of the Reverse Stock Split-Procedural Factors Disfavoring the Reverse Stock Split.”

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Cantabio does not have non-employee directors and does not intend to appoint any (or appoint an unaffiliated representative) to act solely on behalf of unaffiliated security holders for purposes of negotiation of the terms of the transaction described in this information statement or preparing a report concerning the fairness of the reverse stock split. For additional information concerning the appointment of an unaffiliated representative to act on behalf of our unaffiliated stockholders, see “Special Factors-Factors Considered by the Board of Directors as to the Fairness of the Reverse Stock Split-Procedural Factors Disfavoring the Reverse Stock Split.”

Determination of Our Board of Directors

Our board of directors unanimously determined that the reverse stock split is substantively and procedurally fair to, and in the best interests of, our unaffiliated stockholders, whether they are cashed out or remain as stockholders of Cantabio. Our board made this determination after careful consideration of several factors relating to:

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The fairness of the reverse stock split;

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The cash consideration to be paid to stockholders who would otherwise be entitled to receive a fractional share of our new common stock as a result of the reverse stock split; and

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The benefits and consequences of the reverse stock split.

By written consent dated March 13, 2019, the board of directors unanimously approved the reverse stock split, the filing of the certificate of amendment attached as Appendix A hereto, and the transactions contemplated thereby. For additional information concerning the board of director’s approval of the reverse stock split, see “Special Factors-Background of the Reverse Stock Split; Alternatives Considered by Our Board of Directors,” “Special Factors-Reasons for the Reverse Stock Split,” “Special Factors-Factors Considered by Our Board of Directors as to the Fairness of the Reverse Stock Split,” and “Special Factors-Position of Cantabio Regarding the Fairness of the Reverse Stock Split.”

Reservation of Right to Abandon the Reverse Stock Split

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Our board of directors has retained the right to abandon the reverse stock split, even though approved by the board of directors and Cantabio’s stockholders, if the board of directors determines prior to the effective date of the reverse stock split that the reverse stock split is not then in Cantabio’s best interests or the best interests of our stockholders.

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Among the circumstances the board of directors may consider in reaching a decision to abandon the reverse stock split is if the transaction becomes too expensive or there is a risk that it will not result in a reduction in the number of record holders to fewer than 500. For additional information concerning the board of director’s right to abandon the reverse stock split, see “Special Factors-Reservation of Right to Abandon the Reverse Stock Split.”

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Stockholder Approval

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Under Delaware law and Cantabio’s certificate of incorporation, as amended, the approval of the holders of a majority of the outstanding shares of common stock is required to effect the reverse stock split.

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On the record date for notice of action by written consent of our stockholders included at the beginning of this information statement, we had 112,724,148 shares of common stock outstanding, each of which was entitled to one vote

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Our directors and executive officers beneficially own an aggregate of 70.02% of our issued and outstanding stock as follows: (i) Max Zhu, a director, owns approximately 33.5% of our issued and outstanding stock, (ii) Gergely Toth, a director and our Chief Executive Officer, owns approximately 28.5% of our issued and outstanding stock, (iii) Thomas Sawyer, a director and our Chief Operations Officer, owns approximately 8.1% of our issued and outstanding stock.

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Pursuant to Section 228(e) of the Delaware General Corporation Law, we are delivering notice of action by written consent of Cantabio's stockholders to stockholders of record as of the close of business on March 22, 2019, the date on which written consents executed by a sufficient number of stockholders to approve the certificate of amendment were delivered to Cantabio.

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No further stockholder vote, action or consent is necessary, and there will not be a special meeting of stockholders. WE ARE NOT ASKING YOU FOR A PROXY AND WE REQUEST THAT YOU DO NOT SEND US A PROXY. For additional information concerning the stockholders' approval of the reverse stock split, see "The Reverse Stock Split- Stockholder Approval of the Reverse Stock Split; Affiliated Stockholder Ownership."

Dissenters' Rights

Stockholders are not entitled to appraisal rights in connection with the reverse stock split under either Cantabio's governance documents or the Delaware General Corporation Law. For more information, see "The Reverse Split - Dissenters' Rights."

Source of Funds for the Reverse Stock Split

We have cash on hand that will be sufficient to pay out the approximately $22,000 we estimate will be required for the fractional shares resulting from the reverse stock split. For more information, see "The Reverse Stock Split-Source of Funds and Financial Effect of the Reverse Stock Split."

Effect on Our Business

The reverse stock split is not expected to have an immediate affect our current business plan or operations, except for the anticipated cost and employee time savings associated with termination of our public company registration and periodic reporting obligations and the approximate amount of $21,295 of cash that will be spent to effectuate the reverse stock split. We anticipate that as a private entity, we will have increased access to funds and any such funds that we receive could expand our business.  For more information, see "Special Factors - Reasons for the Reverse Stock Split," "Special Factors - Effects of the Reverse Stock Split on Cantabio," and "The Reverse Split - Fees and Expenses."

Trading of Common Stock

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Cantabio's common stock is traded over-the-counter on the OTCQB market maintained by the OTC Markets Group Inc. under the symbol "CTBO."

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On March 12, 2019, shortly before the public announcement of the proposed reverse stock split, the high and low bid prices for Cantabio's common stock was $0.0055 and $0.0030, respectively. For price ranges of Cantabio's common stock, see "Market for Common Stock and Dividend Policy."

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The average trading volume of our common stock in the 90 days prior to March 12, 2019 was 101,141 shares per day and the daily dollar volume during such period was approximately $0.0084.

Material Federal Income Tax Consequences

We believe the reverse stock split will be treated as a tax-free "recapitalization" for federal income tax purposes, which will result in no material federal income tax consequences to Cantabio. Depending on your individual situation, the reverse stock split may give rise to certain income tax consequences. For additional information concerning the potential federal income tax consequences of the reverse stock split, see "Special Factors-Certain Material Federal Income Tax Consequences."

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Providing complete liquidity for our unaffiliated stockholders holding fewer than 5,000 shares and partial liquidity for other unaffiliated stockholders where liquidity has been lacking in the market, and doing so at a fair price through a transaction in which unaffiliated stockholders may be eligible to receive capital gains tax treatment for any realized gains, and avoid paying brokerage commissions and fees;

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Allowing our officers and employees to focus exclusively on our business goals and objectives; and

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Providing access to potential investors that do not invest in publicly held companies.

For additional information concerning the advantages of the reverse stock split and alternatives to the reverse stock split considered by our board of directors, see "Special Factors- Background of the Reverse Stock Split; Alternatives Considered by Our Board of Directors" and "Special Factors-Reasons for the Reverse Stock Split."

Q:

What are some of the disadvantages of the reverse stock split?

A:

Our board of directors believes that the reverse stock split will have the following disadvantages, among others:

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Stockholders owning less than 5,000 shares of our common stock will not have an opportunity to liquidate their shares at a time and for a price of their choosing; instead, they will be cashed out and will no longer be stockholders of Cantabio and will not have the opportunity to participate in or benefit from any future potential appreciation in Cantabio's value.

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Stockholders remaining in Cantabio following the reverse stock split will no longer have available all of the information regarding Cantabio's operations and results that is currently available in our filings with the SEC. As a result of the reverse stock split and resulting termination of our registration and periodic reporting obligations, Cantabio will no longer prepare or file with the SEC, among other things, annual reports on Form 10-KSB or quarterly reports on Form 10-QSB. As a result, our stockholders will no longer be provided, among other things:

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quarterly financial information;

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information concerning our properties, assets and business;

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our management's annual and quarterly reports on our financial condition, results of operations and liquidity and capital resources;

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information concerning our directors and executive officers and their compensation, stock ownership and transactions in our common stock;

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information concerning the stock ownership of our principal stockholders;

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information concerning, and copies of, our corporate and organizational documents and our material contracts and agreements; and

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information concerning material transactions that we enter into.

The elimination of these reporting requirements will result in the loss of financial transparency for unaffiliated stockholders that remain stockholders in Cantabio after the reverse stock split.

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We anticipate that we will no longer prepare proxy materials for our annual meetings of stockholders, and our stockholders may elect to act by written consent of stockholders in lieu of holding annual meetings of stockholders. Cantabio will no longer be subject to the liability provisions of the Securities Exchange Act of 1934, as amended, and will no longer be subject to the provisions of the Sarbanes-Oxley Act of 2002, and our officers will no longer be required to certify the accuracy of our financial statements.

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Stockholders remaining in Cantabio following the reverse stock split will no longer be able to trade our common stock on the over the OTCQB, the effect of which is a loss of liquidity.

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Cantabio will be less likely to be able to use stock to acquire other companies; and it will be more difficult for Cantabio to access the public equity markets.

For additional information concerning the disadvantages of the reverse stock split, see "Special Factors- Factors Considered by Our Board of Directors as to the Fairness of the Reverse Stock Split-Substantive Factors Disfavoring the Reverse Stock Split" and "-Procedural Factors Disfavoring the Reverse Stock Split."

Q:

Cantabio has been publicly held for several years; what are some of the reasons for "going private" now?

A:

Our board of directors believes that Cantabio currently derives no material benefit from its public company status. In addition to the direct financial burden from being a public company, the thin trading market in our common stock has not provided liquidity to our stockholders, nor do we expect that we will be able to use our stock as currency for acquisitions or other transactions in the future. Cantabio is pursuing financing opportunities with potential investors that would not invest in a public company, although to date we have not entered into any binding agreements with such potential investors. These factors, combined with the implementation costs and ongoing expenses to be incurred by Cantabio during 2019 related to the internal controls requirements of Section 404 of the Sarbanes-Oxley Act of 2002, led our board of directors to conclude that Cantabio should terminate its public company status.

Q:

What are some of the factors supporting the board's determination to approve the reverse stock split?

A:

Our board of directors based its determination to approve the reverse stock split on several factors. Importantly, the board of directors considered the relative advantages and disadvantages discussed below and under "Special Factors - Background of the Reverse Stock Split; Alternatives Considered by Our Board of Directors," "-Reasons for the Reverse Stock Split," "-Factors Considered by Our Board of Directors as to the Fairness of the Reverse Stock Split" and "-Position of Cantabio Regarding the Fairness of the Reverse Stock Split." The Board also considered certain other factors, including:

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The analysis regarding the reverse stock split of the board of directors' discussions and conclusions about the fairness, from a financial point of view based upon the report of Albeck Financial Services, of the pre-split share price of $0.01296 to be paid for fractional shares to our unaffiliated stockholders owning less than 5,000 shares or a number of shares not evenly divisible by 5,000.

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The projected tangible and intangible cost savings to Cantabio by terminating its public company status.

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Attempts by our stockholders to achieve liquidity in the existing trading market would be frustrated due to the low average daily trading volume of Cantabio’s common stock on the OTCQB. Only a small number of shares could be purchased or sold on the on the OTCQB without the risk of significantly increasing or decreasing the trading price.

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Q:

What is the total cost of the reverse stock split to Cantabio?

A:

Cantabio estimates that the total cost of the reverse stock split to the Company will be approximately $132,000, of which Cantabio paid or will pay $35,000 for an independent third-party valuation, approximately $22,000 to cash out fractional shares, approximately $55,000 in legal and accounting fees, approximately $5,000 related to the mailing of this information statement, approximately $10,000 for the exchange agent and $5,000 in other costs and expenses to effect the reverse stock split. This total amount could be larger or smaller if the estimated number of fractional shares that will be outstanding after the reverse stock split changes as a result of purchases or sales of common stock by unaffiliated stockholders.

Q:

Why didn't Cantabio's board of directors form a committee of disinterested (or unaffiliated) directors to approve the reverse stock split or require the approval of the holders of a majority of shares which are unaffiliated with Cantabio's board of directors or management?

A:

Our board of directors considered whether, and determined not, to form a committee of disinterested directors or representatives to approve the reverse stock split for several reasons. First, the reverse stock split will be applied equally to all shares of Cantabio, whether held by affiliated or unaffiliated stockholders, and the interests of our unaffiliated and affiliated stockholders are the same. Second, our board of directors is comprised of persons with many years of corporate experience. Finally, our board of directors believes its long-standing familiarity with Cantabio, our financial condition, and our prospects make the time and expense of a special committee or independent representative unwarranted.

The Board also considered submitting the matter of approving the reverse stock split to the holders of a majority of stockholders who are unaffiliated with our board of directors or management. The board questioned whether a it could obtain a quorum (over 50%) of our unaffiliated shareholders for such a vote.  Given that 50% of our unaffiliated shareholders would represent 14,343,816 shares of our common stock, we would need approximately 306 shareholders to vote at such a meeting to obtain a quorum of our minimum shareholders if only our largest unaffiliated shareholders voted (a number that would increase if any of our largest unaffiliated shareholders did not vote.  The board doubted that we would obtain such a quorum as the average shares held by such shareholders was 46,875 shares and the average market value of such shareholders’ shares (using the closing price of $0.0034 per share on March 12, 2019) was under $160.  The board determined that any risk associated with not requiring the approval of at least a majority of our unaffiliated stockholders is mitigated by the procedural factors favoring the reverse stock split, such as the fact that stockholders have the option to remain stockholders of Cantabio if they purchase sufficient shares to bring their holdings to at least 5,000 shares immediately prior to the effective date of the reverse stock split.

Q:

Will I have appraisal rights in connection with the reverse stock split?

A:

No. Neither Delaware law nor our certificate of incorporation, as amended, or bylaws provide you with appraisal rights in connection with the reverse stock split.

Q:

Will I be able to sell my shares following the reverse stock split?

A:

Our common stock is currently traded on the over the OTCQB market. After the reverse stock split, our common stock will no longer be eligible to be quoted on the OTCQB. As a result, stockholders may no longer have the alternative of selling their shares of common stock on the public market, and there may be no effective trading market for our common stock.

Q:

What will be my tax consequences if I hold 5,000 or more shares of common stock at the time of the reverse stock split and remain a stockholder of Cantabio after the reverse stock split?

A.

Depending on your individual situation and depending upon whether you receive cash in addition to shares of new common stock as a result of the reverse stock split, the reverse stock split may give rise to certain income tax consequences:

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If you (1) continue to hold our common stock immediately after the reverse stock split, and (2) receive no cash as a result of the reverse stock split, you should not recognize any gain or loss in the reverse stock split. Your aggregate adjusted tax basis in your shares of our common stock held immediately after the reverse stock split should be equal to your aggregate adjusted tax basis in your shares of common stock held immediately prior to the reverse stock split and you should have the same holding period in your common stock as you had in such stock immediately prior to the reverse stock split.

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If you both receive cash as a result of the reverse stock split and continue to hold our common stock immediately after the reverse stock split, you generally will recognize gain, but not loss, in an amount equal to the lesser of (1) the excess of the sum of aggregate fair market value of the shares of our common stock held by you immediately after the reverse stock split plus the cash received over your adjusted tax basis in the shares held by you immediately before the reverse stock split, or (2) the amount of cash received in the reverse stock split. Your aggregate adjusted tax basis in your shares of our common stock held immediately after the reverse stock split will be equal to your aggregate adjusted tax basis in your shares of our common stock held immediately prior to the reverse stock split, increased by any gain recognized in the reverse stock split, and decreased by the amount of cash received in the reverse stock split.

For additional information concerning the potential federal income tax consequences of the reverse stock split, see "Special Factors-Certain Material Federal Income Tax Consequences."

Q:

What will be my tax consequences if I hold less than 5,000 shares of common stock at the time of the reverse stock split and do not remain a stockholder of Cantabio after the reverse stock split?

A:

Depending on your individual situation, the reverse stock split may give rise to certain income tax consequences. If you (1) receive cash in exchange for a fractional share as a result of the reverse stock split, (2) do not continue to hold any of our stock immediately after the reverse stock split, and (3) you are not related to any person or entity which holds our stock immediately after the reverse stock split, you will recognize capital gain or loss. For additional information concerning the potential federal income tax consequences of the reverse stock split, see "Special Factors-Certain Material Federal Income Tax Consequences."

Q:

Will I continue to receive information about Cantabio if I remain a stockholder?

A:

Stockholders may under certain circumstances obtain information from Cantabio in accordance with the requirements of the General Corporation Law of the State of Delaware upon submitting a written request to Cantabio which specifies the information sought and the purpose of the request. Under Delaware law, Cantabio may withhold information from a stockholder who does not have a "proper purpose" or otherwise fails to comply with statutory requirements.

Q:

Should I send in my stock certificates now?

A:

No. We have appointed Broadridge Financial Solutions, Inc. to act as exchange agent for holders of common stock in connection with the reverse stock split. You may contact the exchange agent at Broadridge Financial Solutions, Inc. by mail at 51 Mercedes Way, Edgewood, NY 11717 or by phone at (855)793-5608.

For those shareholders who will receive cash in lieu of fractional share : We will deposit with the exchange agent, as soon as practicable prior to the Effective Date, cash in an amount equal to the value of the estimated aggregate number of fractional shares that will result from the reverse split. Our stockholder list shows that some of the outstanding common stock is registered in the names of clearing agencies and broker nominees.

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Because we do not know the numbers of shares held by each beneficial owner for whom the clearing agencies and broker nominees are record holders, we cannot predict with certainty the number of fractional shares that will result from the reverse stock split or the total amount the exchange agent will be required to pay for fractional share interests.

For those shareholders who will receive new shares of our common stock : As of the close of business on the effective date of the reverse stock split, each certificate representing shares of common stock outstanding immediately prior to the reverse stock split (“Old Common Stock”) will be deemed, automatically and without any action on the part of individual stockholders, to represent one-five thousandth (1/5,000) the number of shares of Common Stock on its face after the reverse stock split, with any fractional shares voided and paid in cash as discussed above. Each stockholder will be able (but not required) to obtain a New Common Stock certificate evidencing its post-reverse-split shares only by sending the exchange agent its Old Common Stock certificate(s), together with the properly executed and completed Letter of Transmittal, transaction fee, and such evidence of ownership of the shares as we may require. Stockholders will not receive certificates for New Common Stock unless and until their Old Common Stock certificates are surrendered and the transaction fee paid.

The enclosed Letter of Transmittal contains specific instructions relating to the exchange of certificates and must be completed and returned together with the Old Common Stock certificates in order for a New Common Stock certificate to be issued. Upon surrender of an Old Common Stock certificate accompanied by a properly completed and executed Letter of Transmittal, a new certificate representing the New Common Stock and a check payable to the stockholder for any fractional share will be issued and forwarded to the stockholder after the Effective Date. Stockholders whose shares are held in brokerage accounts or in a street name need not submit Old Common Stock certificates for exchange as those shares will automatically reflect the new share amount based on the Reverse Stock Split. The Exchange Agent will not send a separate Letter of Transmittal to the recipients of this information statement, as determined by the Company’s records. The Exchange Agent will, after the Effective Date, send a Letter of Transmittal to any other record holders of the Company’s issued and outstanding Common Stock as of the close of business on the Effective Date. Any stockholder whose Old Common Stock certificate has been lost, destroyed or stolen will be entitled to issuance of a New Common Stock certificate upon compliance with such requirements as the Company and the Exchange Agent customarily apply in connection with lost, stolen or destroyed certificates.

Shareholders should be aware that, under the escheat laws of the various jurisdictions where shareholders may reside, where we are domiciled, and where the funds will be deposited, sums due for fractional interests that are not timely claimed after the effective date of the reverse stock split may be required to be paid to the designated agent for each such jurisdiction, unless correspondence has been received by us or the exchange agent concerning ownership of such funds within the time permitted in such jurisdiction. Thereafter, shareholders otherwise entitled to receive such funds will have to seek to obtain them directly from the state to which they were paid.

Q:

Does Cantabio have any plans for growth and will the reverse stock split enhance the value of Cantabio's common stock?

A:

Our management always hopes that Cantabio will grow and has strategic plans related to its growth. These plans are speculative and contain no factual information which our board of directors considers material to our stockholders. As we have no revenue, these plans would be contingent upon receiving additional funding. Cantabio is pursuing financing opportunities with potential investors that would not invest in a public company, although to date we have not entered into any binding agreements with such potential investors.

We do not know what effect the reverse stock split will have upon the value of our common stock; however, we hope that the savings to be achieved from ceasing to be a public company and the other reasons for the reverse stock split will result in an enhancement in the value of Cantabio and its stock. We cannot assure you on this matter.|

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In addition, during discussions with potential investors to fund our operations and trials, several had indicated that they would not invest in a public company, and that Cantabio would be a more attractive investment opportunity if it were to go private.  We have not entered into any binding agreements with any such potential investors.

During August and September 2018, Mr. Toth began undertaking informal discussions with Cantabio's other directors regarding the possibility of terminating Cantabio's public company status. During these conversations, Mr. Toth advised each of our directors that Cantabio had costs of approximately $130,000 each year as a result of being a public company and also noted that Cantabio had not significantly realized the benefits associated with being a public company, including access to the public capital markets and stockholder liquidity.

During October 2018, Mr. Toth presented a verbal recommendation to the other board members that the subject of privatization be explored as a means of reducing both near-term and long-term overhead costs, reducing Cantabio's exposure to corporate governance rules and increasing its ability to attract investors. Mr. Toth recommended that the board of directors consider structuring the proposed transaction in such a way as to prevent any adverse effect to our existing operations. Mr. Toth’s recommendation also pointed out that Cantabio was not in a position to take full advantage of its public company status, which rendered the cost of maintaining such status unwarranted.

Based on these discussions, during October 2018, each member of the board of directors agreed with Mr. Toth that serious consideration should be given to the cost reductions associated with privatization provided that the result of going private would not cause a default in the approximately $895,000 in principal (plus accrued interest) of outstanding convertible debentures that were issued from January 25, 2017 to June 5, 2018.  Cantabio would default under these debentures if it went private. Subsequently, we ended up paying off these notes with proceeds from new convertible notes.

During October, November and December of 2018, Mr. Toth and Mr. Sawyer held telephone discussions with representatives of Ortoli Rosenstadt LLP, Cantabio's outside legal counsel. Various methods to accomplish a going private transaction were reviewed, including an examination of a cash out merger, a tender offer, a sale of Cantabio to, or merger of Cantabio with, another organization, a reverse stock split, and purchases of Cantabio's common stock on the open market.

During these discussions, the following strategic alternatives in addition to the reverse stock split were considered:

1.

Cash-Out Merger . Our board of directors considered a "cash-out" merger, in which Cantabio would merge with an entity controlled by certain of Cantabio's executive officers and directors and their affiliates, that would result in many of the unaffiliated holders of our common stock receiving cash for their shares. The board discussed the fact that, as with a sale transaction, in a cash-out merger, all holders of common stock, other than the members of the buy-out group, would be paid cash for their shares whether or not they wanted to retain their equity position. A cash-out merger would be more costly to Cantabio and Stockholders who were not invited to participate as members of the buy-out group would have all of their Cantabio common stock acquired in the cash-out merger, would not continue as stockholders of the acquiring or surviving entity, and therefore would not have the opportunity to participate in any growth in the value of Cantabio following the cash-out merger. The board of directors noted that, conversely, in a reverse stock split, only stockholders who own a number of shares smaller than the reverse split ratio would be unable continue as stockholders of Cantabio, and any stockholder who desires to continue as a stockholder after the reverse stock split could acquire an additional number of shares of shares of common stock in order to increase his or her ownership to a number of shares greater than the selected reverse split ratio. Our board of directors elected against the cash-out merger because of its inherent unfairness to the stockholders being frozen out and the higher costs of effecting a cash-out merger.

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2.

Sale of Substantially all of our Assets . Another possibility considered by our board of directors was the sale of substantially all of our assets in a spin out.  This would have likely been constructed so that the sale of our assets would have been to an entity controlled by certain of our largest shareholders and the cash received from the sale distributed to the shareholders as a dividend. In addition to being more expensive, this option would not have given all shareholders the option of continuing to participate in the potential upside of our assets.  The current structure allows those shareholders holding less than 5,000 shares to purchase a number of shares in the open market that will allow them to remain shareholders of Cantabio after the reverse stock split.

During these discussions, the board also considered the benefits and disadvantages of:

1.

forming a special committee of the board comprised of independent directors (of which we had none) or other independent persons to consider and review the reverse stock split and to make a recommendation to the full board as to the approval of the reverse stock split. Specifically, the board discussed the fact that the reverse stock split applies equally to all stockholders, including the directors and officers, and that no director, executive officer or affiliate of Cantabio would receive any benefit not received by any other stockholder. Furthermore, the board noted that the director’s ownership percentage of our common stock as a group would only increase from approximately 70.02% to approximately 71.05%, as a result of the reverse stock split. Based on these factors, the board of directors determined not to appoint a special committee of the board.

2.

requiring the approval of the reverse stock split by the holders of a majority of the shares of common stock held by our unaffiliated stockholders. In considering whether to require the approval of our unaffiliated stockholders, the board discussed the fact that stockholders would have the option to remain stockholders of Cantabio if they purchase sufficient shares to bring their holdings to at least 5,000 shares immediately prior to the effective date of the reverse stock split, the fact that the reverse stock split applies equally to all stockholders, the fact that our affiliate stockholders' percentage ownership would likely not significantly change after the reverse stock split and the likely inability to obtain have a majority of the non-affiliate shareholders participate in such a vote. Based on these factors, the board of directors determined not to require the approval of the reverse stock split by the holders of a majority of the shares of common stock held by our unaffiliated stockholders.

The board also discussed in detail other aspects of the going private transaction, including the price to be paid to stockholders in lieu of fractional shares. In that regard, the Company noted that its trading history was limited and its volume of trading low and, as a result, neither might accurately reflect the value of the Company’s common stock.  To better determine the value of its common stock, the Company hired Albeck Financial Services to prepare a report on the valuation of the Company’s common stock.

The board also identified and undertook discussions of the disadvantages of the reverse stock split, namely, the fact that stockholders of record owning less than 5,000 shares would not be able to participate in any future growth of Cantabio. The board noted that this disadvantage is minimized by the fact that any stockholder who so chooses can remain a stockholder by purchasing a sufficient number of shares in order to increase the number of shares in such stockholder's record account to more than 5,000. Another disadvantage discussed by the board is the fact that stockholders who remain after the reverse stock split will no longer have access to information concerning our operations and financial results that is currently available in our SEC filings.

On March 5, 2019, the board received the report of Albeck Financial Services which stated a per share valuation of $0.01296. On March 7, 2019, the board discussed this report and preliminarily concluded that a valuation of $0.01296 per share would be fair to the shareholders who would receive fractional shares as a result of the reverse stock split.

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Based on these considerations, on March 12, 2019, the board determined by written resolution that the results of a reverse stock split are more predictable and automatic, and determined that the reverse stock split is the most expeditious and economical way of reducing the number of holders of record to fewer than 500 and effecting the termination of our registration and periodic reporting obligations. Our board of directors unanimously approved an amendment to Cantabio's certificate of incorporation that, upon filing with the Delaware Secretary of State, will give effect to a 1-for-5,000 reverse stock split of Cantabio's common stock.

In addition, the reverse stock split will terminate the equity interests of beneficial owners of less than 5,000 shares whose shares are held in "street name" by their broker or other record owner. The reverse stock split is expected to relieve Cantabio of the administrative burdens and costs associated with filing reports and otherwise complying with the requirements of registration under the federal securities laws by deregistering Cantabio's common stock. In addition, the reverse stock split would provide small stockholders a beneficial mechanism to liquidate their equity interest at a fair price for their shares without having to pay brokerage commissions, particularly in light of the limited trading liquidity available to holders of Cantabio's common stock.

This transaction will help Cantabio control unnecessary expenses and to cut general and administrative costs by eliminating the expenses and our employees' time and effort related to our registration and periodic reporting obligations under the Securities Exchange Act of 1934, as amended, and the related stockholder servicing expenses associated with being an SEC reporting company. Annual costs associated with Cantabio's registration and periodic reporting obligations, including auditors' fees, attorneys' fees, insurance costs, transfer agent fees, printing, postage and other stockholder communications expenses, stock transfer fees and other miscellaneous fees associated with being a publicly held company and servicing stockholders amount to approximately $130,000. The overall executive time currently devoted to our public company reporting obligations could be devoted to other purposes such as preparing for clinical trials and developing our product candidates.

Aspects of Remaining Public

Our board of directors believes that Cantabio and its stockholders currently derive no material benefit from continued registration under the federal securities laws. Throughout Cantabio's time as a public company, Cantabio has explored potential alternatives to increase stockholder value and attract investor interest and in some instances has implemented such measures.  Generally, Cantabio has been unsuccessful in attracting investor interest despite operating a publicly held company for several years. Cantabio has been unable to provide increased value to our stockholders as a public company

The tangible and intangible costs of being a public company are not justified because we have not been able to realize many of the benefits that publicly traded companies sometimes realize. Our board of directors does not believe Cantabio is in a position to use its status as a public company to raise capital through sales of securities in a public offering or to otherwise access the public markets to raise equity capital. Our common stock's small public float and limited trading volume have limited the ability of our stockholders to sell their shares without also reducing our trading price. The lack of liquidity also limits our ability to use its stock as acquisition currency or to successfully attract and retain employees. During the 90 day period prior to March 12, 2019, the average daily trading volume of Cantabio's common stock on the OTCQB was approximately 101,141 shares per day, which, using the closing price for shares of our common stock on March 12, 2019 would amount to sales of approximately $344 of our shares of common stock per day.

Continuing as a public company would provide certain benefits, namely a public market for the sale and exchange of shares, stockholder liquidity, and readily accessible financial, business and management information about Cantabio. The reason for terminating these benefits is that they are expensive and of limited effect for small, public companies like Cantabio. Over the past 12 months, very little trading has taken place in Cantabio's securities, affording stockholders little liquidity for their shares. Cantabio's market capitalization is so small that it does not attract substantial investment activity or analyst interest. Consequently, the benefits that generally accompany status as a publicly traded company provide little practical benefit to Cantabio. As a result, our board of directors has determined that the costs of remaining a publicly traded entity outweigh the benefits for Cantabio.

Unwieldy Capital Structure

Cantabio's ownership structure is unwieldy. Cantabio is a small, public company by any measure, including gross assets, market value, gross revenues, employees, net loss, etc. Our stockholder base is quite large compared to our size. In addition, we have an inordinate number of stockholders owning a very small number of shares.  For example 1,671 of our approximately 2,010 shareholders hold shares with an aggregate market value of under $17 using the closing price for shares of our common stock on March 12, 2019 of $0.0034.

Factors Considered by Our Board of Directors as to the Fairness of the Reverse Stock Split

Our board of directors has analyzed the reverse stock split and its anticipated effects on our stockholders, and all of the members of our board of directors, including each director who is not an employee of Cantabio, deemed the reverse stock split and related termination of our registration and periodic reporting obligations to be substantively and procedurally fair to, and in the best interests of, both our affiliated and unaffiliated stockholders, whether they are cashed out or remain as stockholders following the reverse stock split. In reaching this conclusion, our board of directors considered, in no particular order and without preference, the following factors:

Substantive Factors Favoring the Reverse Stock Split

Our board of directors considered, in no particular order and without preference, a number of factors in determining the substantive fairness of the reverse stock, including:

The reverse stock split offers stockholders who hold fewer than 5,000 shares the opportunity to dispose of their holdings at a premium above current market prices, average historic market prices and net book value without brokerage commissions. Our board of directors hired an independent evaluator to provide a valuation of our common stock.  This report recommended a per share price of $0.01296.

The Board weighed this valuation against other several methods it used to value our common stock to determine the $0.01296 per share of existing common stock to pay to stockholders who will have fractional shares of our common stock as a result of the reverse stock split. These other valuation methods that the board considered included:

*

Current and historical market prices of our common stock. On March 12, 2019, shortly before the public announcement of the proposed reverse stock split, the high and low bid prices for Cantabio's common stock was $0.0055 and $0.003, respectively. Over the past 12 months, our outstanding common stock traded at prices ranging between $0.0990 and $0.0030 per share. The 90 day average closing price for the period ending March 12, 2019 was $0.0084.

*

Net Book Value .  As of September 30, 2018, the net book value per share of our outstanding common stock was negative $2,422,882. This net book value is based on our consolidated balance sheet as of September 30, 2018.

*

Other Valuation Methods Not Considered.  The board of directors did not consider the following valuation methods because such information was not available to, or does not apply to, Cantabio:

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Prices paid in previous purchases by Cantabio of its securities during the past two years. Our board of directors did not consider this valuation method because Cantabio has not purchased any securities during the past two years, either on the open market or repurchases directly from stockholders.

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Liquidation value. Our board of directors does not believe liquidation value to be a reliable indicator of our value because the liquidation of our intellectual properties through one or more transactions would not provide a price reflective of the value our intellectual properties. Our board of directors was unable, as a result of the uncertainty regarding the additional costs and taxes, to establish a reliable estimate of liquidation value.

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Firm offers of which Cantabio is aware made by an unaffiliated person during the past two years for the merger or consolidation of Cantabio with another company, the sale or other transfer of assets and purchase of Cantabio's securities enabling the holder to exercise control over Cantabio.  Cantabio is not aware of any such offers in the past two years.

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After considering these valuation methods, our board of directors concluded to rely on the report of the independent evaluators and chose the valuation provided as it concluded that this best reflected the per share value based on the other valuation methods used by the board.

The cash consideration of $0.01296 per share to be paid for fractional shares is 381% of Cantabio's current market price (based on a closing price of $0.0034 on March 12, 2019, shortly before the public announcement of the proposed reverse stock split) and more than 154% of the 90 day average closing price prior to March 12, 2019. As such, our board of directors considers it to be fair to Cantabio's stockholders. The price per share is made even more fair by the fact that Cantabio is committed to paying any transaction fees that are imposed on our stockholders by a bank, brokerage firm or other nominee, such as brokerage commissions and service charges, as a result of the reverse stock split.

The reverse stock split ratio is fair and equitable to unaffiliated stockholders. The purpose of the reverse stock split is to reduce the number of record holders to fewer than 500 so that Cantabio can file to terminate its registration and periodic reporting obligations and continue future operations as a private company. The split ratio is a result of calculations that were intended to determine how many shares needed to be eliminated to reduce the number of record holders to fewer than 500. Our board of directors feels the current ratio of 1-for-5,000 is fair because it was calculated without bias towards any one group of stockholders. The ratio will be applied equally to all shares Cantabio's common stock and is not designed to increase any one person's position, ownership or financial gain as a result of the reverse stock split.

Procedural Factors Favoring the Reverse Stock Split

The reverse stock split provides Cantabio's stockholders with liquidity.   The average daily trading volume for Cantabio's common stock over the last three months was less than one-tenth of a percent (0.1%) of its outstanding stock. The reverse stock split will provide stockholders who hold fewer than 5,000 shares on the effective date of the reverse stock split the opportunity to liquidate their investment in Cantabio. Under normal circumstances and based on the high trading price per share of $0.006 as of March 12, 2019, a trading day shortly before the public announcement of the proposed reverse stock split, stockholders with fewer than 5,000 shares wanting to sell their common stock would likely incur transaction fees that are disproportionately high relative to the market value of their holding of our common stock. The reverse stock split will eliminate this problem for those stockholders because Cantabio will pay any transaction fees that are imposed on our stockholders by a bank, brokerage firm or other nominee, such as brokerage commissions and service charges, as a result of the reverse stock split.

The reverse stock split includes the ability to remain a stockholder of Cantabio.  Another factor considered by our board of directors in determining the procedural fairness of the transaction to unaffiliated stockholders is that current holders of fewer than 5,000 shares of our common stock may elect to remain stockholders of Cantabio by acquiring sufficient shares so that they hold at least 5,000 shares in their account immediately prior to the reverse stock split.

Conversely, stockholders who desire to liquidate their shares of Cantabio's common stock for the cash consideration offered may reduce their holdings to less than 5,000 shares prior to the reverse stock split. Our board of directors considers the structure of the reverse stock split to be fair to all stockholders because it allows them to control the decision of whether to remain a stockholder of Cantabio following the reverse stock split or to receive the cash consideration offered in connection with the reverse stock split.

No material change in percentage ownership of the affiliated stockholders.  Because we estimate that less than 1,643,296 out of 112,724,148 shares of our common stock will be cancelled as a result of the reverse stock split, the percentage ownership of stockholders that remain after the reverse stock split will change only slightly from their ownership prior to the reverse stock split.

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For example, our affiliated stockholders currently own approximately 74% of our outstanding common stock and will own approximately 75% following completion of the reverse stock split. The fact that the transaction has been structured in a manner that maintains a substantially similar percentage ownership of the stockholders, whether affiliated or unaffiliated, who remain after the reverse stock split, supports the fairness of the transaction to our stockholders.

No unusual conditions to the reverse stock split.    Our board of directors also considered the likelihood that the reverse stock split would be implemented. In this regard the board took into consideration that there are no unusual requirements or conditions to the reverse stock split, and the fact that Cantabio has the financial resources to implement the reverse stock split expeditiously.  The reverse stock split is not a condition precedent to any binding agreement of Cantabio.

Substantive Factors Disfavoring the Reverse Stock Split

Cessation of public sale opportunities.  Following the reverse stock split, Cantabio will apply for the termination of its registration and periodic reporting obligations with the SEC. Once we terminate our registration and periodic reporting obligations, our common stock will no longer be eligible to be quoted on the OTCQB. As a result, stockholders may no longer have the alternative of selling their shares of common stock on the public market, and there may be no effective trading market for our common stock. As a result, any stockholder desiring to sell his or her shares may have a difficult time finding a buyer. Such illiquidity may reduce the price a buyer is willing to pay for your shares. We anticipate that the public market for shares of Cantabio's common stock will be substantially reduced or eliminated altogether. Additionally, we do not have any present intention or plans to sell Cantabio or enter into any other transaction that would provide liquidity for your shares.

However, the current public market is highly illiquid. As a practical matter, there currently exists very little liquidity for our common stock; therefore, our board of directors believes any further losses of liquidity will have little effect on unaffiliated stockholders and will be outweighed by the benefits of terminating our registration and periodic reporting obligations. In addition, because the effect of further losses of liquidity due to ineligibility for quotation on the OTCQB will have the same impact on all of our stockholders, whether affiliated or unaffiliated, our board of directors does not believe that this factor makes the transaction unfair to unaffiliated stockholders.

Cessation of publicly available information.  Stockholders remaining in Cantabio following the reverse stock split will no longer have available all of the information regarding Cantabio that is currently available in our filings with the SEC. As a result of the reverse stock split and resulting termination of our registration and periodic reporting obligations, Cantabio will no longer prepare or file annual or quarterly reports with the SEC. As a result, our stockholders will no longer be provided, among other things:

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audited financial statements and quarterly financial information;

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information concerning our properties, assets and business;

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our management's annual and quarterly reports on our financial condition, results of operations and liquidity and capital resources;

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information concerning our directors and executive officers and their compensation, stock ownership and transactions in our common stock;

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information concerning the stock ownership of our principal stockholders;

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information concerning, and copies of, our corporate and organizational documents and our material contracts and agreements; and

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information concerning material transactions that we enter into.

This information that is currently available to the general public and our investors through our SEC filings will not be publicly available once we terminate the registration of our securities and our registration and periodic reporting obligations. The elimination of these reporting requirements will result in the loss of financial transparency for unaffiliated stockholders that remain stockholders in Cantabio after the reverse stock split.

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Our board of directors does not believe this factor makes the transaction unfair to unaffiliated stockholders because any detriment to unaffiliated stockholders that may result from the termination of the registration of our securities and our periodic filings will be offset by the anticipated cost-saving benefits and competitive advantages to Cantabio of no longer publicly filing such reports.

In addition, those of our stockholders who have restricted securities because they purchased their shares from Cantabio in unregistered, private-placement transactions will be unable to resell their shares of Cantabio's common stock under the exemptions provided by SEC Rule 144, unless and until (a) we resume filing the information required under that rule with the SEC or (b) such stockholders are eligible to sell their shares pursuant to SEC Rule 144(k). Given the current and historically low trading volume in our common stock, our board of directors does not believe that the unavailability of the Rule 144 exemptions is a factor that makes the transaction unfair to unaffiliated stockholders.

Inability to participate in any future increase in the value of our common stock.  Stockholders who are cashed out as a result of the reverse stock split will have no further interest in Cantabio with respect to their cashed out shares, and thus will not have the opportunity to participate in the potential upside of any increase in the value of such shares. Our board of directors determined that this factor does not make the transaction unfair to unaffiliated stockholders because those unaffiliated stockholders who desire to hold shares of our common stock after the reverse stock split can do so by acquiring sufficient shares so that they hold at least 5,000 shares in their account immediately prior to the reverse stock split.

Procedural Factors Disfavoring the Reverse Stock Split

The reverse stock split has not been structured to require the separate approval of directors unaffiliated with Cantabio.   Among the factors weighing against the procedural fairness of the reverse stock split is the fact that our board of directors did not establish an independent or special committee to represent the interests of our unaffiliated stockholders. Our board members consented to the reverse stock split as affiliated stockholders and the holders of a majority of the voting power of Cantabio. In addition, our board of directors has not and does not intend to have a majority of its non-employee directors retain an unaffiliated representative to act solely on behalf of unaffiliated security holders for purposes of negotiation of the terms of the reverse stock split or preparing a report concerning the fairness of the reverse stock split.

Our board of directors did not establish an independent or special committee or other unaffiliated representative to act on behalf of the interests of the unaffiliated stockholders for several reasons. First and foremost, the reverse stock split will be applied equally to all shares of Cantabio, whether held by affiliated or unaffiliated stockholders. Unlike a third party tender offer or a repurchase of shares by Cantabio, there is no price to negotiate on behalf of the unaffiliated stockholders. In the case of the reverse stock split, the board of directors is tasked with determining a fair price to offer all stockholders. Therefore, the interests of the unaffiliated and affiliated stockholders are the same. Additionally, our board of directors believes its long-standing familiarity with Cantabio, our financial condition, and our prospects make the time and expense of a special committee or independent representative unwarranted. Given the experience level and make up of our board of directors, Cantabio did not believe it was necessary to appoint a special committee to evaluate the fairness of the terms of the reverse stock split or the value of our common stock.

The reverse stock split has not been structured so as to require the approval of at least a majority of our unaffiliated stockholders.  Our board of directors considered it a risk and potentially negative factor to the procedural fairness of the reverse stock split that the approval of the reverse stock split by a majority of the unaffiliated stockholders is not being sought. This risk is mitigated by the likelihood that a quorum of such unaffiliated shareholders would not be obtained and procedural factors favoring the reverse stock split, such as the fact that stockholders have the option to remain stockholders of Cantabio if they purchase sufficient shares to bring their holdings to at least 5,000 shares immediately prior to the effective date of the reverse stock split.

Position of Cantabio Regarding the Fairness of the Reverse Stock Split

Our board of director has unanimously approved the reverse stock split and declared it advisable, in the best interests of, and substantively and procedurally fair to, our unaffiliated stockholders, whether they are cashed out or remain as stockholders of Cantabio. In reaching these conclusions, our board of directors considered, among other things, the following factors relating to the fairness of the reverse stock split:

Substantive Fairness

*

The cash consideration of $0.01296 per share to be paid for fractional shares represents over a 381% premium on Cantabio's current market price (based on a closing price of $0.0034 on March 12, 2019, shortly before the public announcement of the proposed reverse stock split) and more than 154% of the 90 day average closing price of $0.0084 for the 90 day period prior to March 12, 2019);

*

Those unaffiliated stockholders who continue as stockholders following the reverse stock split will maintain a substantially similar percentage ownership that they had prior to the reverse stock split;

*

Cashed-out stockholders will be unable to participate in the future growth of Cantabio, if any;

*

The potential loss of liquidity in shares of our common stock does not appear to be a significant loss given the historically small trading volume of our common stock over the past 12 months; and

*

Any detriment associated with the reduction in public information available regarding our business, financial conditions and results of operations will be offset by the savings in costs and officer and employee time expected to result from termination of our registration and periodic reporting obligations; and

Procedural Fairness

*

The fact that the transaction was structured so as to not require the approval of at least a majority of the unaffiliated stockholders;

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The absence of a special committee or independent representative for our unaffiliated stockholders or a fairness opinion of an independent financial advisor.

*

The equal application of the reverse stock split on all shares of common stock, whether held by an affiliated or unaffiliated stockholder;

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The experience of our board of directors;

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Unaffiliated stockholders will have an opportunity to liquidate their historically illiquid holdings at a premium and without brokerage fees; and

*

Unaffiliated stockholders can decide to remain stockholders of Cantabio after the reverse stock split by simply acquiring sufficient shares so that they hold at least 5,000 shares in their account immediately prior to the reverse stock split.

Notwithstanding the lack of additional procedural safeguards, such as the consent of a majority of our unaffiliated stockholders or a fairness opinion rendered by an independent financial advisor, our board of directors believes that it has acted in the best interest of both our affiliated and unaffiliated stockholders, whether they are to be cashed out or remain as stockholders of Cantabio, and that the fairness determination and approval of the transaction has been procedurally fair.

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In view of the foregoing, the board of directors of Cantabio believes that sufficient procedural safeguards exist to ensure the fairness of the reverse stock split and that the positive factors outweighed the negative factors, such that the reverse stock split is substantively and procedurally fair to the unaffiliated stockholders of Cantabio.

Interests of Our Directors and Executive Officers in the Reverse Stock Split

You should be aware that our board of directors and our executive officers may have interests in the reverse stock split that are or may be different from, or in addition to, your interests as one of our stockholders. Each of our directors and our executive officers own more than 5,000 shares of common stock, as follows:

Unlike stockholders who own less than 5,000 shares of Cantabio common stock on the effective date of the reverse stock split, each of the directors and the executive officers listed above will have the opportunity to participate in the potential upside of any increase in the value of Cantabio's common stock after the reverse stock split. In addition, we expect our directors and our executive officers to retain their respective current positions as directors or executive officers of Cantabio following the reverse stock split, with the exception of our Chief Financial Officer who has indicated that he expects to resign shortly after the reverse stock split.

Each of our directors and our executive officers will receive the same cash consideration as our unaffiliated stockholders for fractional shares of common stock to which they would be entitled as a result of the reverse stock split.

All amounts owed to these stockholders as a result of the reverse stock split will be subject to applicable federal and state income taxes. Additional details regarding the federal tax consequences are described later in this information statement under the heading "Certain Material Federal Income Tax Consequences."

As soon as practical after the consummation of the reverse stock split, we or our transfer agent will mail a letter of transmittal to each stockholder. The letter of transmittal will contain instructions for the surrender of your stock certificate or certificates to Cantabio's exchange agent in exchange for the payment of the cash consideration to be received for fractional shares of new common stock. No cash payment will be made to any stockholder until the stockholder has surrendered his or her outstanding certificates, together with the letter of transmittal, to our exchange agent. For more detailed information, see the section entitled "Stock Certificates."

Effects of the Reverse Stock Split on Our Affiliates' Interests in Our Net Book Value and Net Loss

The interests of each of our directors, executive officers and beneficial owners of more than 5% of our outstanding common stock in our net book value and net loss will change only slightly as a result of the reverse stock split. The following table sets forth the interest of our affiliates in our net book value, in terms of both dollar amounts and percentages, immediately prior to the reverse stock split and immediately following the reverse stock split. We have used our net book value of negative $2,422,882 as of September 30, 2018 and the equity interests of the named person as of March 12, 2019 to compute the amount prior to the reverse stock split. To compute the amount following the reverse stock split, we adjusted our net book value as of September 30, 2018 to give effect to the reverse stock split and the related transactions, which resulted in an adjusted net book value of negative $2,555,882, and we adjusted the equity interests of the named person to give effect to the reverse stock split. To calculate the equity interest of each named person we compared the person's beneficially owned shares of common stock plus shares of common stock that can be acquired by that person from exercising options that will vest within 60 days of March 12, 2019, with the total number of shares of common stock outstanding on March 12, 2019 plus shares of common stock that can be acquired by that person from exercising options within 60 days of March 12, 2019.

The following table sets forth the interests of each of our directors, executive officers and beneficial owners of more than 5% of our outstanding common stock in our net loss, in terms of both dollar amounts and percentages, immediately prior to the reverse stock split and immediately following the reverse stock split. We have used our net loss of $568,616 for the quarter ended September 30, 2018 and the equity interest of the named person to compute the amount prior to the reverse stock split. To compute the amount following the reverse stock split, we adjusted the equity interests of the named person to give effect to the reverse stock split. The equity interest of each named person was computed in the same manner as the immediately preceding table.

Deregistration Under the Securities Exchange Act of 1934; Termination of Quotation on the OTCQB

Our common stock is currently registered under the Securities Exchange Act of 1934, as amended, and consequently we are subject to its registration and periodic reporting obligations. We believe the reverse stock split will reduce the number of beneficial holders of our common stock from approximately 2,010 to approximately 339. The reverse stock split will allow us to file to terminate our registration and periodic reporting obligations and continue future operations as a private company.

We believe that following the completion of the reverse stock split and the subsequent termination of our registration and periodic reporting obligations, we the market for shares of our common stock will be substantially reduced or possibly eliminated. Our common stock is currently traded on the OTCQB, and last sales prices are reported on the OTCQB, which is a regulated quotation service that displays real time quotes, last sales prices and volume information in over-the-counter equity securities. If we terminate our registration and periodic reporting obligations, our common stock will cease to be eligible to be traded on the OTCQB and this source of liquidity will no longer be available to our stockholders.

Cost Savings to be Achieved as a Result of the Termination of Our Registration and Reporting Obligations

We are undertaking the reverse stock split at this time to, among other things, eliminate substantial costs and our officers' and employees' time and effort related to our registration and periodic reporting obligations under the Securities Exchange Act of 1934, as amended, and the related stockholder servicing expenses associated with being an SEC reporting company. Annual costs associated with Cantabio's registration and periodic reporting obligations, including auditors' fees, attorneys' fees, payroll expenses, insurance costs, transfer agent fees, printing, postage and other stockholder communications expenses, stock transfer fees and other miscellaneous fees associated with being a publicly held company and servicing stockholders amount to approximately $130,000 The following table sets forth the estimated annual cost savings to be achieved as a result of the termination of our registration and reporting obligations:

Cash Consideration to be Paid to Our Stockholders in Lieu of Fractional Shares of New Common Stock

Based on the aggregate number of stockholders of our common stock, and the number of stockholders of record owning more than 5,000 shares of our common stock as of the record date for notice of the action by written consent of our stockholders, we estimate that payments of cash in lieu of the issuance of fractional shares to unaffiliated stockholders will total approximately $21,295 in the aggregate, or 1,693,246 pre-split shares multiplied by the cash consideration of $0.01296 per pre-split share. No stockholder with a single account is expected to receive more than $64.78. If stockholders holding less than 5,000 shares of Cantabio's common stock purchase sufficient shares of Cantabio's common stock to remain stockholders following the reverse stock split or if multiple stockholders holding 5,000 or more shares in street name through nominees, such as banks and brokers, register their shares in their own name, then the number of holders of record of Cantabio's common stock may not be reduced below 500 and Cantabio may be ineligible to terminate its registration and periodic reporting obligations. In addition, more stockholders than we anticipate may reduce their holdings of our common stock in the accounts to below 5,000 shares, so that they can be cashed out, which would increase the costs associated with the reverse stock split.

For an itemized list of the other fees and expenses that have been incurred or that are estimated to be incurred in connection with the reverse stock split and the transactions related to the reverse stock split, see "The Reverse Stock Split - Fees and Expenses" below.

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Conduct of Our Business and Operations After the Reverse Stock Split

We expect that following completion of the reverse stock split, our operations will be conducted substantially as they are currently being conducted. Other than the reverse stock split and the termination of our registration and periodic reporting obligations, we have no present plans or proposals that relate to or would result in an extraordinary corporate transaction involving our corporate structure, business or management, such as a merger, reorganization, liquidation, relocation of any operations or sale or transfer of a material amount of assets. However, we will continue to evaluate our business and operations after the reverse stock split, and may develop new plans and proposals in the future, and expect to pursue the acquisition of additional oil and natural gas properties.

Equity Interests and Rights of our Stockholders After the Reverse Stock Split

The rights of our holders of common stock as set out in our Articles of Incorporation and our Bylaws and under Delaware corporate law will not change as a result of the reverse stock split. We have no current plans to issue common stock other than pursuant to our existing stock plans, warrants, options and convertible notes, but not only do we reserve the right to do so at any time and from time to time at such prices and on such terms as our board of directors determines to be in our best interests and the best interests of our stockholders, but we anticipate that we will need to do so to raise sufficient capital to continue our operations as envisioned. Our common stock carries no preemptive or preferential rights to purchase any of our stock that we may issue in the future, and neither our existing certificate of incorporation nor our bylaws currently contain any provisions that have a material anti-takeover effect. Persons who continue as stockholders following implementation of the reverse stock split will not have any preemptive or other preferential rights to purchase any of our stock that we may issue in the future, unless such rights are specifically granted to the stockholders. Other than as described in this information statement, we have no current agreements to effect any extraordinary corporate transaction such as a merger, reorganization or liquidation, to sell or transfer any material amount of our assets, to change our board of directors or management, to change materially our or capitalization, or otherwise to effect any material change in our corporate structure of business. Our board of directors will take such action, as it deems necessary or appropriate to make equitable adjustments to any outstanding stock options or other rights to acquire our common stock.

financial institutions, regulated investment companies, real estate investment trusts, holders who are dealers in securities or foreign currency, traders in securities that elect to use a mark-to-market method of accounting for securities holdings, tax-exempt organizations, insurance companies, holders that received their Common Stock pursuant to the exercise of employee stock options or otherwise as compensation, persons liable for alternative minimum tax, holders who hold their Common Stock as part of a hedge, straddle, conversion, constructive sale or other integrated transaction, or holders whose functional currency is not the U.S. dollar. In addition, this summary does not address the tax consequences of the Reverse Split arising under the unearned income Medicare contribution tax or under the laws of any foreign, state or local jurisdiction or any U.S. federal tax consequences other than federal income taxation, including any U.S. federal estate or gift tax consequences. The discussion below neither binds nor precludes the Internal Revenue Service (the “IRS”) from adopting a position contrary to that expressed below, and the Company cannot assure holders that such a contrary position could not be asserted successfully by the IRS and adopted by a court if the position were litigated.

We will not obtain a ruling from the IRS or an opinion of counsel regarding the federal income tax consequences to the shareholders of the Company as a result of the Reverse Split. Accordingly, you are encouraged to consult your own tax advisor regarding the specific tax consequences of the proposed Reverse Split, including the application and effect of state, local, and foreign income and other tax laws.

This summary assumes that you are one of the following: (i) a citizen or resident of the United States; (ii) a domestic corporation; (iii) an estate the income of which is subject to United States federal income tax regardless of its source; or (iv) a trust if a United States court can exercise primary supervision over the trust’s administration and one or more United States persons are authorized to control all substantial decisions of the trust. This summary also assumes that you have held and will continue to hold your shares as capital assets for federal income tax purposes.

You should consult your tax advisor as to the particular federal, state, local, foreign, and other tax consequences applicable to your specific circumstances.

The decision to engage in the Reverse Split at this time is not the result of any tax consequences of the Reverse Split. We believe that the Reverse Split will be treated as a tax-free “recapitalization” for federal income tax purposes. This should result in no material federal income tax consequences to the Company or to the shareholders who do not receive cash in the Reverse Split. However, if you are a Cashed-Out Stockholder receiving cash in the Reverse Split, you may not qualify for tax free “recapitalization” treatment for federal income tax purposes.

Federal Income Tax Consequences to Shareholders Who Do Not Receive Cash in Connection with the Reverse Split

If you (i) continue to hold stock directly immediately after the Reverse Split and (ii) you receive no cash as a result of the Reverse Split, you should not recognize any gain or loss in the Reverse Split for federal income tax purposes. Your aggregate adjusted tax basis in your shares of stock held immediately after the Reverse Split will be equal to your aggregate adjusted tax basis in your shares of stock held immediately prior to the Reverse Split and you will have the same holding period in your stock as you had in such stock immediately prior to the Reverse Split.

Federal Income Tax Consequences to Shareholders Who Receive Cash in Connection with the Reverse Split

If you (i) receive cash in exchange for fractional shares as a result of the Reverse Split, (ii) you do not continue to hold any stock directly immediately after the Reverse Split, and (iii) you are not related to any person or entity that holds stock immediately after the Reverse Split, you will recognize capital gain or loss on the Reverse Split for federal income tax purposes, with such gain or loss measured by the difference between the cash you receive for your cashed out stock and your aggregate adjusted tax basis in such stock.

If you receive cash in exchange for fractional shares as a result of the Reverse Split, but either continue to directly own stock immediately after the Reverse Split, or are related to a person or entity who continues to hold stock immediately after the Reverse Split, you will recognize capital gain or loss in the same manner as set forth in the previous paragraph, provided that your receipt of cash either (i) is “not essentially equivalent to a dividend,” (ii) constitutes a “substantially disproportionate redemption of stock,” or (iii) constitutes a “complete termination of interest,” as described below.

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(i) “Not Essentially Equivalent to a Dividend.” You will satisfy the “not essentially equivalent to a dividend” test if the reduction in your proportionate interest in the Company resulting from the Reverse Split (taking into account for this purpose the stock owned by persons related to you) is considered a “meaningful reduction” given your particular facts and circumstances. The Internal Revenue Service has ruled that a small reduction by a minority shareholder whose relative stock interest is minimal and who exercises no control over the affairs of the corporation will satisfy this test.

(ii) “Substantially Disproportionate Redemption of Stock.” The receipt of cash in the Reverse Split will be a “substantially disproportionate redemption of stock” for you if the percentage of the outstanding shares of stock of the Company owned by you (and by persons related to you) immediately after the Reverse Split is (a) less than 50% of all outstanding shares and (b) less than 80% of the percentage of shares of stock owned by you (and by persons related to you) immediately before the Reverse Split.

(iii) “Complete Termination of Interest.” To satisfy the “complete termination of interest” test, you cannot continue to hold any stock directly immediately after the Reverse Split. If you are treated as owning shares of stock actually or constructively owned by certain individuals and entities related to you, you may still satisfy the requirements of this test if you (a) retain no interest in the corporation immediately after the Reverse Split (including any interest as an officer, director, or employee), other than an interest as a creditor, (b) do not acquire an interest in the corporation within ten years after the date of the Reverse Split, and (c) agree to notify the Internal Revenue Service of the acquisition of any interest in the corporation within that ten-year period. You should consult your tax advisor for details if you find that these facts describe your situation and you wish to recognize capital gain or loss on the receipt of cash for your cashed out stock.

In applying these tests, you will be treated as owning shares of stock actually or constructively owned by certain individuals and entities related to you. If your receipt of cash in exchange for stock is not treated as capital gain or loss under any of the tests, it will be treated first as ordinary dividend income to the extent of your ratable share of the Company’s current and accumulated earnings and profits, then as a tax-free return of capital to the extent of your aggregate adjusted tax basis in your shares, and any remaining amount will be treated as capital gain. For a more detailed discussion, please see “Capital Gain and Loss” and “Special Rate for Certain Dividends” in this section below. If your receipt of cash in exchange for stock is treated as ordinary dividend income, you may not receive any tax benefit from your basis in such shares.

Capital Gain and Loss

For individuals, net capital gain (defined generally as your total capital gains in excess of capital losses for the year) recognized upon the sale of capital assets that have been held for more than 12 months generally will be subject to tax at a rate not to exceed 15%. Net capital gain recognized from the sale of capital assets that have been held for 12 months or less will continue to be subject to tax at ordinary income tax rates. Capital gain recognized by a corporate taxpayer will continue to be subject to tax at the ordinary income tax rates applicable to corporations. There are limitations on the deductibility of capital losses.

Special Rate for Certain Dividends

In general, dividends are taxed at ordinary income rates. However, you may qualify for a 15% rate of tax on any cash received in the Reverse Split that is treated as a dividend as described above, if (i) you are an individual or other non-corporate shareholder, (ii) you have held the share of stock with respect to which the dividend was received for more than 60 days during the 121-day period beginning 60 days before the ex-dividend date, as determined under the Code, and (iii) you were not obligated during such period (pursuant to a short sale or otherwise) to make related payments with respect to positions in substantially similar or related property. You are urged to consult with your tax advisor regarding your applicability for, and the appropriate federal, state, local, foreign or other tax treatment of, any such dividend income.

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Backup Withholding

Shareholders will be required to provide their social security or other taxpayer identification numbers (or, in some instances, additional information) to the Transfer Agent in connection with the Reverse Split to avoid backup withholding requirements that might otherwise apply. The letter of transmittal will require each shareholder to deliver such information when the Common Stock certificates are surrendered following the Effective Date of the Reverse Split. Failure to provide such information may result in backup withholding at a rate of 28%.

As explained above, the amounts paid to you as a result of the Reverse Split may result in dividend income, capital gain income, or some combination of dividend and capital gain income to you depending on your individual circumstances. You should consult your tax advisor as to the particular federal, state, local, foreign, and other tax consequences of the Reverse Split, in light of your specific circumstances.

Tax Consequences of the Reverse Split to the Company

With respect to the Reverse Split, the Company generally should not recognize any gain or loss for U.S. federal income tax purposes. Under the Code, an “ownership change” with respect to a corporation can significantly limit the amount of pre-ownership change net operating losses (“NOLs”) and certain other tax assets that the corporation may utilize after the ownership change to offset future taxable income. Very generally, an ownership change occurs if the aggregate stock ownership of holders of at least 5% of a corporation’s stock increases by more than 50 percentage points over the preceding 3-year period. The Company does not expect the Reverse Split to have a material impact on its NOLs or other relevant tax assets, as determined for U.S. federal income tax purposes.

THE PRECEDING DISCUSSION OF THE MATERIAL U.S. FEDERAL INCOME TAX CONSEQUENCES OF THE REVERSE SPLIT IS GENERAL AND DOES NOT INCLUDE ALL CONSEQUENCES TO EVERY SHAREHOLDER UNDER FEDERAL, STATE, LOCAL, OR FOREIGN TAX LAWS. ACCORDINGLY, EACH SHAREHOLDER SHOULD CONSULT ITS OWN TAX ADVISOR AS TO THE PARTICULAR TAX CONSEQUENCES TO IT OF THE REVERSE SPLIT, INCLUDING THE APPLICABILITY AND EFFECT OF ANY STATE, LOCAL, OR FOREIGN TAX LAWS, AND OF ANY PROPOSED CHANGES IN APPLICABLE LAW.

If you currently hold less than 5,000 shares of our common stock and you want to continue to hold our common stock after the reverse stock split, you may do so by taking either of the following actions far enough in advance so that it is complete before the close of business on the date of effectiveness of the filing of the certificate of amendment to effect the reverse stock split:

*

purchase a sufficient number of shares of our common stock on the open market and have them registered in your name and consolidated with your current record account if you are a record holder, or have them entered in your account with a nominee, such as your broker or bank, in which you currently hold shares of our common stock, so that you hold at least 5,000 shares of our common stock in your record account immediately prior to the effective date of the reverse stock split; or

*

if applicable, consolidate your record accounts, or your accounts with nominees, so that you hold at least 5,000 shares of our common stock in a single record account immediately prior to the effective date of the reverse stock split.

Because of the limited trading market for our common stock, you may be unable to purchase enough shares to retain an equity interest in Cantabio.

We intend for the reverse stock split to treat stockholders holding common stock in street name through a nominee, such as a bank or broker, in the same manner as stockholders whose shares are registered in their names. Nominees will be instructed to effect the reverse stock split for their beneficial holders. However, nominees may have different procedures and stockholders holding shares in street name should contact their nominees.

The reverse stock split is structured as a "going private" transaction under SEC Rule 13e-3 promulgated under the Securities Exchange Act of 1934, as amended, because it is intended to, and if completed will likely, reduce the number of record holders of our common stock to fewer than 500, which will permit us to terminate our registration and periodic reporting obligations. In connection with the reverse stock split, we have filed a Rule 13e-3 transaction statement on Schedule 13E-3 with the SEC. We intend to apply for the termination of our registration and periodic reporting obligations as soon as practicable after the effective date of the reverse stock split.

All stock certificates evidencing ownership of Cantabio common stock outstanding immediately prior to the reverse stock split will be deemed for all purposes to represent (a) a claim for cash payment in lieu of a fractional share of new Cantabio common stock and/or (b) new certificates representing the number of shares of new Cantabio common stock that will result from the reverse stock split, whether or not the certificates representing existing Cantabio common stock are surrendered for exchange. Do not send your stock certificates to Cantabio or our transfer agent until you have received a transmittal letter and followed the instructions therein.

Fees and Expenses

The following is a reasonably itemized statement of the fees and expenses that have been incurred or that are estimated to be incurred in connection with the reverse stock split and the transactions related to the reverse stock split:

*

$22,000 in cash consideration to our stockholders in lieu of fractional shares of new common stock;

*

$55,000 in legal and accounting fees;

*

$35,000 for the preparation of a third-party valuation of our shares;

*

$5,000 for printing, mailing and other costs in connection with the mailing of this information statement;

*

$10,000 to Broadridge Financial Solutions, Inc.  for exchange agent services; and

*

$5,000 for miscellaneous expenses.

Cantabio has paid or will be responsible for paying all fees and expenses incurred or to be incurred in connection with the reverse stock split and the transactions related to the reverse stock split.

MARKET FOR COMMON STOCK AND DIVIDEND POLICY

The last reported sales price for our shares on the OTCQB as of March 12, 2019, was $0.0034 per share. As of March 13, 2019, we had 20 shareholders of record.

Our Drug Discovery Approach

Our mission is to commercialize innovative drug candidates with novel mechanisms of action as well as intellectual property generated from our research activities for neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. Our research efforts focus on the discovery and development of therapeutic small molecule pharmacological chaperones targeting proteins that misfold and aggregate in vivo.

Focusing on specific therapeutic targets we thoroughly investigate target family biophysics, bringing together a combination of drug discovery technologies, from initial screening through to specific disease assays, and understanding of disease biology into our innovative drug discovery approach, through which we identify and develop small molecule pharmacological chaperones and protein-based therapies for clinical trials for neurodegenerative and other diseases.

A pharmacological chaperone is a small molecule that can enter cells and bind to either a folded or misfolded structure of a protein to stabilize it or route it to the native folded functional form.

Our therapeutic targets consist of proteins that misfold, aggregate and lose their function or/and gain a toxic function in vivo.  Our small molecule pharmacological chaperones are designed to stabilize the native functional form of specific protein targets, thereby reducing their misfolding and aggregation and enabling the target protein’s function or preventing and/or eliminating the toxic function caused by these changes.

The use of pharmacological chaperones is a unique therapeutic approach that can directly target specific proteins to improve native function and protect from toxic function and thereby treat disease. We are applying a proprietary process to discover novel small molecule pharmacological chaperone drug candidates by applying biophysics based screening technologies in combination with cell-based models of the targeted diseases, which provide validation of the therapeutic effect of the identified pharmacological chaperones. In many cases, we can apply structure-based drug design for hit to lead and lead optimization.

In addition, we are pursuing the application of protein delivery technologies that enable the delivery of proteins into patients’ brain, supplementing low functional levels of these proteins in disease conditions.  Our therapeutic targets in this project are proteins, which display loss of function in disease-affected cells.  Our technologies involve the development and application of novel protein constructs, fusing specific proteins with unique cell permeable polypeptides, with the capability to pass through the blood-brain barrier and enter the central nervous system.

Our Directors and Executive Officers

The following table provides information regarding our executive officers and directors as of March 19, 2019.

Each of our directors will serve in that capacity until our next annual shareholder meeting or until their successors are elected and qualified. Officers hold their positions at the will of our Board of Directors. There are no arrangements, agreements or understandings between non-management security holders and management under which non-management security holders may directly or indirectly participate in or influence the management of our affairs.

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Dr. Gergely Toth , President, Chief Executive Officer, Director

Dr. Tóth received his MSc in Chemistry at the University of Szeged and later his PhD from the Department of Biomedical Sciences at Creighton University in 2001. He was a post-doctoral fellow at the Department of Molecular Biology at the University of California at Berkeley between 2001 and 2002. Dr. Tóth is a graduate of the Global BioExecutive program of the BioExecutive Institute (University of California, Berkeley, Haas School of Business; 2005). Dr. Tóth also received an Executive MBA from the University of Cambridge (UK) in 2012.

Dr. Tóth founded Gardedam in 2009. Dr. Tóth is also affiliated with the University of Cambridge in the UK, (Department of Clinical Neurosciences, Wolfson Brain Imaging Centre) since 2009, where he has been an Investigator in the NIHR Biomedical Research Unit on Dementia and of the Neurodegenerative Disease Initiative on AD funded by the Wellcome Trust and Medical Research Council. In addition, Dr. Tóth heads the Neurodegenerative Disease Drug Discovery research group since 2014 at the Academy of Sciences of Hungary in Budapest. Dr. Tóth’s research interests are the biophysical/structural biology aspects and therapeutic targeting of proteins that misfold and lose their native functions and/or gain toxic functions implicated in neurodegenerative diseases. Dr. Tóth is also a visiting lecturer in the Business of Biotechnology at the School of Pharmacy at the University College London.

Previously, Dr. Tóth was at Protein Mechanics (California, Mountain View) (later Locus Pharmaceuticals) where he was the Director of Computer Aided Drug Discovery Group between 2002-2005. Here he was a key contributor to leading both research and business development efforts and to selling Protein Mechanics to Locus Pharmaceuticals in 2004. From 2005-2009, Dr. Tóth was at Elan Pharmaceuticals (California, South San Francisco) in various roles mostly in drug discovery research for Parkinson’s and Alzheimer’s diseases. Dr. Tóth has been a strategic scientific consultant at Elan Pharmaceuticals between 2009-2013. Dr. Tóth published over 35 peer reviewed articles and patents on the topics of life sciences, drug discovery and the business of biotechnology, and he actively presents in various international conferences.

Dr. Thomas Roger Sawyer , Chief Operations Officer, Director

Dr. Sawyer completed his doctorate in biological sciences at the University of Glasgow in 2000 and quickly moved into the corporate world, starting the information technology companies Weather2 Limited and Advanced Weather Applications for which he served in the role of Chief Technology Officer. While helping to build and grow these companies, he also began consulting for clients in the logistics industry, providing strategy, technical architecture and business process consultancy for companies including Global Freight Solutions and Nightline.

Dr. Sawyer completed an Executive MBA at the University of Cambridge, graduating in 2012, specializing in corporate finance and management science and completed his thesis on the use of data for predictive analytical tools in industry. It was from Cambridge that he was recruited to work for private equity investors providing advice on project due diligence, appraisal, corporate structuring and economic valuation of minerals assets in southern and eastern Africa. After completing the due diligence work on assets and carrying out the initial corporate structuring he was appointed CEO of East African Gold plc, a gold exploration company headquartered in Mauritius and with extensive exploration licenses in the east African country of Uganda, in late 2011, continuing in this role until the end of 2014 when the company ceased operations. Under his leadership, the company successfully raised capital in excess of USD $4 million and carried out extensive exploration activities in a large area in a remote region of the country, with up to 100 employees and wide-reaching operations capabilities.

In 2015, Dr. Sawyer began mentoring start-up companies at the University of Cambridge and worked on various consulting projects including a proposal to finance Gardedam Therapeutics, culminating in the company’s rebranding, restructuring and a reverse merger at the end of 2015, and his appointment to the board. In 2016, he was appointed a Director of Cognetivity Ltd, a UK based company developing an artificial intelligence driven diagnostic test for dementia.

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Dr. Sawyer has extensive experience starting and structuring companies, raising capital, IPOs, mergers, setting up joint ventures and corporate strategy. His background in research science allows him to incorporate the technical aspects of the development of projects with his experience in management and corporate finance, allowing this to be built into the overall business strategy and direction. He has lectured as a guest lecturer at the University of Cambridge, teaching entrepreneurial finance to MBA students, at University College London teaching finance of drug development to MSc students at the School of Pharmacy and at Exeter University teaching corporate finance and behavior to MSc students, and has been a speaker at international conferences. Dr. Sawyer has board experience in a number of industries; for Weather2 and Advanced Weather Applications in the area of information technology and business intelligence; Capro Ltd, an investment advisory and consultancy company specializing in consultancy and direct investment in growing businesses, in the extractive industry as Director of each of the East African Gold group companies, and for Cognetivity Ltd working on a SaaS solution for dementia diagnosis. He brings to the Company his abilities in strategic planning, corporate structuring, operations management, analytical modeling and the ability to raise capital to fund growth.

Dr Max Zhu , Director

Dr. Max Zhu is a scientist entrepreneur, investor and consultant. He has been a research scientist and Head of Computer-Aided Drug Design at Cantabio Pharmaceuticals Inc. from 2015-18. He has been an investor and shareholder in the company since 2015; more recently from 2018, he became a Director and was named head of business development for the company targeting the Asia-Pacific region.

Dr. Zhu obtained his PhD at the University of Cambridge researching Alzheimer ’ s Disease in 2013. His thesis focused on computational studies of the amyloid- β and that led to the discovery of a set of compounds which could become potential drug leads for AD. This research brought together his experience in computer science, AI, genome and protein structure analysis, computational biology and chemistry, where the combination of different skillsets and knowledge was needed in cross/multi-disciplinary biomedical research.

After completing his PhD, Dr. Zhu was first a scientist at VITA-Genes and then a director / technology officer at Vitargent Biotechnologies, both are biotech companies based in the Hong Kong Science Park. He developed extensive knowledge and know-how in biomedical innovations and R&D commercialization in the region in this period. At both companies he was also involved in business development and strategies as well as sales and marketing, gaining experience as a biotech entrepreneur in the greater China area.