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| Date | Nom du détenteur | Actions transigées | Fourchette de valeur ($) | Type d'opération | Fourchette de prix ($) | Actions en fin de déclaration | % de variation |
|---|---|---|---|---|---|---|---|
| 2026-03-16 | Dr. Padmanabh P. BhattChief Scientific Officer & Senior VP of Intellectual Property | -107,25k | 1,50M | Derivative Exercise and Sale | 27,94 - 50,73 | 17,04k | - |
| 2026-03-12 | Mr. Frederick M. HudsonIndependent Director | -5,37k | 271,73k | Vente | 50,61 | 60,41k | -8,16% |
| 2026-03-13 | Mr. Jack A. KhattarFounder, President, CEO, Secretary & Director | -35,00k | 1,76M | Automatic Disposition | 50,09 - 51,75 | 2,20M | -1,57% |
| 2026-03-13 | Mr. Jack A. KhattarFounder, President, CEO, Secretary & Director | -12,50k | 0,00 | Other Disposition | - | 2,20M | -0,57% |
| 2026-03-06 | Mr. Jack A. KhattarFounder, President, CEO, Secretary & Director | 22,07k | 0,00 | Derivative Exercise and Retained Stock | - | 2,23M | 1,00% |
| 2026-03-06 | Mr. Jack A. KhattarFounder, President, CEO, Secretary & Director | -16,57k | 907,10k | Derivative Exercise and Sale | 54,73 | 2,23M | - |
| 2026-03-06 | Mr. Timothy C. DecSenior VP & CFO | 3,12k | 0,00 | Derivative Exercise and Retained Stock | - | 8,23k | 60,94% |
| 2026-03-06 | Mr. Timothy C. DecSenior VP & CFO | -2,88k | 157,79k | Derivative Exercise and Sale | 54,73 | 8,23k | - |
| 2026-03-06 | Mr. Frank MottolaSenior VP & Chief Technology Operations Officer | 334,00 | 0,00 | Derivative Exercise and Retained Stock | - | 18,44k | 1,84% |
| 2026-03-06 | Mr. Frank MottolaSenior VP & Chief Technology Operations Officer | -3,42k | 185,20k | Derivative Exercise and Sale | 53,65 - 54,73 | 18,44k | - |
| 2026-03-06 | Dr. William Todd HorichSenior VP & Chief Commercial Officer | 6,38k | 0,00 | Derivative Exercise and Retained Stock | - | 0,00 | -100,00% |
| 2026-03-06 | Dr. William Todd HorichSenior VP & Chief Commercial Officer | -1,13k | 61,13k | Derivative Exercise and Sale | 54,00 - 54,73 | 0,00 | - |
| 2026-03-09 | Dr. William Todd HorichSenior VP & Chief Commercial Officer | -8,27k | 451,18k | Vente | 54,00 - 55,00 | 0,00 | -100,00% |
| 2026-03-06 | Dr. William Todd HorichSenior VP & Chief Commercial Officer | -2,93k | 160,58k | Sale to Issuer | 54,73 | 0,00 | -100,00% |
| 2026-03-06 | Dr. Georges GemayelIndependent Director | -7,91k | 218,97k | Derivative Exercise and Sale | 25,30 - 53,00 | 27,28k | - |
| 2026-03-05 | Dr. Georges GemayelIndependent Director | -10,88k | 583,85k | Vente | 53,00 - 53,71 | 27,28k | -28,52% |
| 2026-02-25 | Mr. Frank MottolaSenior VP & Chief Technology Operations Officer | -977,00 | 49,52k | Sale to Issuer | 50,69 | 18,11k | -5,12% |
| 2026-02-25 | Mr. Timothy C. DecSenior VP & CFO | -1,28k | 64,83k | Sale to Issuer | 50,69 | 5,12k | -20,00% |
| 2026-02-25 | Dr. Padmanabh P. BhattChief Scientific Officer & Senior VP of Intellectual Property | -650,00 | 32,95k | Sale to Issuer | 50,69 | 17,04k | -3,67% |
| 2026-02-25 | Dr. Jonathan RubinSenior VP of Research & Development and Chief Medical Officer | -675,00 | 34,22k | Sale to Issuer | 50,69 | 13,34k | -4,82% |
| 2026-02-24 | Mr. Timothy C. DecSenior VP & CFO | -2,37k | 120,78k | Sale to Issuer | 50,86 - 51,35 | 3,89k | -37,83% |
| 2026-02-24 | Dr. Padmanabh P. BhattChief Scientific Officer & Senior VP of Intellectual Property | -1,58k | 80,69k | Sale to Issuer | 50,86 - 51,35 | 16,44k | -8,77% |
| 2026-02-24 | Mr. Frank MottolaSenior VP & Chief Technology Operations Officer | -1,64k | 83,76k | Sale to Issuer | 50,86 - 51,35 | 17,21k | -8,71% |
| 2026-02-24 | Dr. Jonathan RubinSenior VP of Research & Development and Chief Medical Officer | -1,64k | 49,73k | Sale to Issuer | 50,86 - 51,35 | 12,77k | -11,40% |
| 2026-02-23 | Dr. Georges GemayelIndependent Director | 15,00k | 194,70k | Derivative Exercise and Retained Stock | 12,98 | 38,16k | 64,77% |
| 2026-02-19 | Ms. Bethany L. SensenigIndependent Director | -4,48k | 228,26k | Derivative Exercise and Sale | 50,31 - 51,27 | 0,00 | - |
| 2026-01-09 | Mr. Frederick M. HudsonIndependent Director | 15,00k | 194,70k | Derivative Exercise and Retained Stock | 12,98 | 61,31k | 32,39% |
| 2025-12-19 | Mr. Frank MottolaSenior VP & Chief Technology Operations Officer | -20,00k | 431,65k | Derivative Exercise and Sale | 25,30 - 50,47 | 15,50k | - |
| 2025-12-18 | Dr. Padmanabh P. BhattChief Scientific Officer & Senior VP of Intellectual Property | 790,00 | 0,00 | Derivative Exercise and Retained Stock | - | 14,51k | 5,76% |
| 2025-12-18 | Dr. Padmanabh P. BhattChief Scientific Officer & Senior VP of Intellectual Property | -710,00 | 31,55k | Derivative Exercise and Sale | 44,44 | 14,51k | - |
| 2025-11-21 | Mr. Charles W. NewhallIndependent Chairman of the Board | 15,00k | 194,70k | Derivative Exercise and Retained Stock | 12,98 | 119,64k | 14,33% |
| 2025-10-09 | Mr. Jack A. KhattarFounder, President, CEO, Secretary & Director | 21,35k | 540,16k | Derivative Exercise and Retained Stock | 25,30 | 2,21M | 0,97% |
| 2025-10-09 | Mr. Jack A. KhattarFounder, President, CEO, Secretary & Director | -59,90k | 1,51M | Derivative Exercise and Sale | 25,30 - 51,46 | 2,21M | - |
| 2025-10-09 | Mr. Charles W. NewhallIndependent Chairman of the Board | -25,00k | 1,27M | Automatic Disposition | 50,73 - 51,55 | 104,64k | -19,28% |
| 2025-10-02 | Mr. Jack A. KhattarFounder, President, CEO, Secretary & Director | 24,36k | 9,18k | Derivative Exercise and Retained Stock | 25,30 | 2,19M | 1,12% |
| 2025-10-02 | Mr. Jack A. KhattarFounder, President, CEO, Secretary & Director | -17,23k | 751,50k | Derivative Exercise and Sale | 25,30 - 48,06 | 2,19M | - |
| 2025-10-01 | Mr. Jack A. KhattarFounder, President, CEO, Secretary & Director | 13,61k | 344,38k | Derivative Exercise and Retained Stock | 25,30 | 2,17M | 0,63% |
| 2025-10-01 | Mr. Jack A. KhattarFounder, President, CEO, Secretary & Director | -40,17k | 914,74k | Derivative Exercise and Sale | 25,30 - 48,07 | 2,17M | - |
| 2025-09-30 | Mr. Jack A. KhattarFounder, President, CEO, Secretary & Director | 2,92k | 73,93k | Derivative Exercise and Retained Stock | 25,30 | 2,15M | 0,14% |
| 2025-09-30 | Mr. Jack A. KhattarFounder, President, CEO, Secretary & Director | -8,59k | 197,09k | Derivative Exercise and Sale | 25,30 - 48,25 | 2,15M | - |
| 2025-09-29 | Mr. Jack A. KhattarFounder, President, CEO, Secretary & Director | 3,45k | 87,36k | Derivative Exercise and Retained Stock | 25,30 | 2,15M | 0,16% |
| 2025-09-29 | Mr. Jack A. KhattarFounder, President, CEO, Secretary & Director | -10,24k | 232,54k | Derivative Exercise and Sale | 25,30 - 48,02 | 2,15M | - |
| 2025-09-25 | Dr. Jonathan RubinSenior VP of Research & Development and Chief Medical Officer | 1,04k | 0,00 | Derivative Exercise and Retained Stock | - | 11,02k | 10,37% |
| 2025-09-25 | Dr. Jonathan RubinSenior VP of Research & Development and Chief Medical Officer | -840,00 | 38,82k | Derivative Exercise and Sale | 46,21 | 11,02k | - |
| 2025-09-23 | Mr. Jack A. KhattarFounder, President, CEO, Secretary & Director | 18,43k | 239,18k | Derivative Exercise and Retained Stock | 12,98 | 2,15M | 0,87% |
| 2025-09-23 | Mr. Jack A. KhattarFounder, President, CEO, Secretary & Director | -29,51k | 1,01M | Derivative Exercise and Sale | 12,98 - 47,23 | 2,15M | - |
| 2025-09-22 | Mr. Jack A. KhattarFounder, President, CEO, Secretary & Director | -16,59k | 564,62k | Derivative Exercise and Sale | 12,98 - 47,02 | 2,13M | - |
| 2025-09-22 | Mr. Jack A. KhattarFounder, President, CEO, Secretary & Director | 10,47k | 135,94k | Derivative Exercise and Retained Stock | 12,98 | 2,13M | 0,49% |
| 2025-09-12 | Mr. Frank MottolaSenior VP & Chief Technology Operations Officer | -5,00k | 32,35k | Derivative Exercise and Sale | 39,40 - 45,87 | 15,50k | - |
| 2025-09-08 | Mr. Jack A. KhattarFounder, President, CEO, Secretary & Director | 1,75k | 44,33k | Derivative Exercise and Retained Stock | 25,30 | 2,12M | 0,08% |
| 2025-09-08 | Mr. Jack A. KhattarFounder, President, CEO, Secretary & Director | -6,32k | 132,70k | Derivative Exercise and Sale | 25,30 - 46,29 | 2,12M | - |
| 2025-09-05 | Mr. Jack A. KhattarFounder, President, CEO, Secretary & Director | 17,60k | 445,23k | Derivative Exercise and Retained Stock | 25,30 | 2,12M | 0,84% |
| 2025-09-05 | Mr. Jack A. KhattarFounder, President, CEO, Secretary & Director | -55,58k | 1,15M | Derivative Exercise and Sale | 25,30 - 46,01 | 2,12M | - |
| 2025-08-27 | Mr. Jack A. KhattarFounder, President, CEO, Secretary & Director | 21,17k | 274,84k | Derivative Exercise and Retained Stock | 12,98 | 2,10M | 1,02% |
| 2025-08-27 | Mr. Jack A. KhattarFounder, President, CEO, Secretary & Director | -34,80k | 1,12M | Derivative Exercise and Sale | 12,98 - 45,12 | 2,10M | - |
| 2025-08-27 | Mr. Charles W. NewhallIndependent Chairman of the Board | -3,59k | 161,50k | Automatic Disposition | 45,01 | 129,64k | -2,69% |
| 2025-08-25 | Dr. Padmanabh P. BhattChief Scientific Officer & Senior VP of Intellectual Property | 669,00 | 0,00 | Derivative Exercise and Retained Stock | - | 13,72k | 5,13% |
| 2025-08-25 | Dr. Padmanabh P. BhattChief Scientific Officer & Senior VP of Intellectual Property | -581,00 | 24,09k | Derivative Exercise and Sale | 41,46 | 13,72k | - |
| 2025-08-25 | Mr. Frank MottolaSenior VP & Chief Technology Operations Officer | -14,00k | 441,42k | Derivative Exercise and Sale | 12,98 - 44,51 | 15,50k | - |
| 2025-08-25 | Mr. Charles W. NewhallIndependent Chairman of the Board | -1 000,00 | 45,00k | Automatic Disposition | 45,00 | 133,23k | -0,74% |
| 2025-08-25 | Mr. Jack A. KhattarFounder, President, CEO, Secretary & Director | 611,00 | 7,93k | Derivative Exercise and Retained Stock | 12,98 | 2,08M | 0,03% |
| 2025-08-25 | Mr. Jack A. KhattarFounder, President, CEO, Secretary & Director | -1 000,00 | 32,02k | Derivative Exercise and Sale | 12,98 - 45,00 | 2,08M | - |
| 2025-08-22 | Mr. Charles W. NewhallIndependent Chairman of the Board | -1,41k | 63,54k | Automatic Disposition | 45,00 | 134,23k | -1,04% |
| 2025-08-22 | Mr. Timothy C. DecSenior VP & CFO | -11,78k | 524,09k | Vente | 44,49 | 1,25k | -90,43% |
| 2025-08-22 | Mr. Jack A. KhattarFounder, President, CEO, Secretary & Director | 915,00 | 11,88k | Derivative Exercise and Retained Stock | 12,98 | 2,08M | 0,04% |
| 2025-08-22 | Mr. Jack A. KhattarFounder, President, CEO, Secretary & Director | -1,50k | 48,03k | Derivative Exercise and Sale | 12,98 - 45,00 | 2,08M | - |
| 2025-08-14 | Ms. Bethany L. SensenigIndependent Director | -5,37k | 226,84k | Automatic Disposition | 42,25 | 0,00 | -100,00% |
| 2025-08-14 | Mr. Frederick M. HudsonIndependent Director | -7,46k | 315,13k | Vente | 42,26 | 46,31k | -13,87% |
| 2025-08-06 | Mr. Jack A. KhattarFounder, President, CEO, Secretary & Director | 61,25k | 1,01M | Derivative Exercise and Retained Stock | 12,98 - 25,30 | 2,08M | 3,04% |
| 2025-08-06 | Mr. Jack A. KhattarFounder, President, CEO, Secretary & Director | -140,00k | 3,28M | Derivative Exercise and Sale | 12,98 - 43,12 | 2,08M | - |
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