Addendum to Genentech Announces Fourth Quarter and Full Year 2004 Results (FINANCIAL TABLES) SOUTH SAN FRANCISCO, Calif., Jan. 10 /PRNewswire-FirstCall/ -- GENENTECH, INC. CONDENSED CONSOLIDATED STATEMENTS OF INCOME (in thousands, except per share amounts) (unaudited) Three Months Ended December 31, 2004 GAAP(1) Difference Non-GAAP(2) Revenues: Product sales $1,066,302 $1,066,302 Royalties 181,220 181,220 Contract revenue 67,778 67,778 Total operating revenues 1,315,300 1,315,300 Costs and expenses: Cost of sales 205,373 205,373 Research and development 310,196 310,196 Marketing, general and administrative 299,495 299,495 Collaboration profit sharing 170,070 170,070 Recurring charges related to redemption 34,534 $(34,534) (3) -- Special items: litigation-related (3,189) 3,189 (4) -- Total costs and expenses 1,016,479 (31,345) 985,134 Operating margin 298,821 31,345 330,166 Other income, net (5) 21,323 21,323 Income before taxes 320,144 31,345 351,489 Income tax provision 113,560 12,540 126,100 Net income $206,584 $18,805 $225,389 Earnings per share:(6) Basic $0.20 $0.01 $0.21 Diluted $0.19 $0.02 $0.21 Weighted average shares used to compute earnings per share:(6) Basic 1,049,700 1,049,700 Diluted 1,070,708 1,070,708 (1) Reflects operating results in accordance with U.S. generally accepted accounting principles (or GAAP). (2) Non-GAAP amounts exclude litigation-related special items, recurring charges related to the 1999 redemption of Genentech's Special Common Stock, net of tax effects. (3) Represents the amortization of other intangible assets related to the 1999 redemption of Genentech's Special Common Stock. (4) Represents released accrual on a litigation matter; amounts received in Q4 2003 related to the Bayer litigation settlement; and also includes accrued interest and bond costs for Q4 2004 and 2003 related to the City of Hope trial judgment. (5) "Other income, net" includes realized gains and losses from the sale of certain biotechnology equity securities and write-downs for other-than- temporary declines in the fair value of certain biotechnology debt and equity securities. In addition, "other income, net" includes interest income and interest expense. For further detail, refer to our web site at http://www.gene.com/. (6) All share and per share amounts reflect the May 2004 two-for-one stock split of our Common Stock. 2005 Reconciliation of GAAP and Non-GAAP EPS Our 2005 GAAP EPS is not estimable at this time. The 2005 GAAP EPS would include recurring charges related to the 1999 redemption of our stock by Roche, which are estimated to be approximately $123 million on a pretax basis in 2005. In addition, the 2005 GAAP EPS would include litigation-related special charges for accrued interest and associated bond costs on the City of Hope judgment, which are currently estimated to be approximately $14 million on a pretax basis in 2005. The 2005 non-GAAP EPS estimate does not include the redemption related recurring charges and the litigation-related special charges or any other potential special charges related to existing or future litigation or its resolution, or changes in accounting principles, all of which may be significant. Three Months Ended December 31, 2003 GAAP(1) Difference Non-GAAP(2) Revenues: Product sales $723,736 $723,736 Royalties 148,307 148,307 Contract revenue 61,856 61,856 Total operating revenues 933,899 933,899 Costs and expenses: Cost of sales 126,202 126,202 Research and development 215,627 215,627 Marketing, general and administrative 263,505 263,505 Collaboration profit sharing 133,927 133,927 Recurring charges related to redemption 38,586 $(38,586)(3) -- Special items: litigation-related (8,119) 8,119(4) -- Total costs and expenses 769,728 (30,467) 739,261 Operating margin 164,171 30,467 194,638 Other income, net(5) 20,334 20,334 Income before taxes 184,505 30,467 214,972 Income tax provision 57,774 12,170 69,944 Net income $126,731 $18,297 $145,028 Earnings per share:(6) Basic $0.12 $0.02 $0.14 Diluted $0.12 $0.02 $0.14 Weighted average shares used to compute earnings per share:(6) Basic 1,047,391 1,047,391 Diluted 1,071,529 1,071,529 GENENTECH, INC. CONDENSED CONSOLIDATED STATEMENTS OF INCOME (in thousands, except per share amounts) (unaudited) Year Ended December 31, 2004 GAAP(1) Difference Non-GAAP(2) Revenues: Product sales $3,748,879 $3,748,879 Royalties 641,119 641,119 Contract revenue 231,159 231,159 Total operating revenues 4,621,157 4,621,157 Costs and expenses: Cost of sales 672,526 672,526 Research and development 947,513 947,513 Marketing, general and administrative 1,088,111 1,088,111 Collaboration profit sharing 593,616 593,616(3) Recurring charges related to redemption 145,485 $(145,485) (3) -- Special items: litigation-related 37,087 (37,087) (4) -- Total costs and expenses 3,484,338 (182,572) 3,301,766 Operating margin 1,136,819 182,572 1,319,391 Other income, net (5) 82,597 82,597 Income before taxes and cumulative effect of accounting change 1,219,416 182,572 1,401,988 Income tax provision 434,600 73,031 507,631 Income before cumulative effect of accounting change 784,816 109,541 894,357 Cumulative effect of accounting change, net of tax -- -- -- Net income $784,816 $109,541 $894,357 Earnings per share (7): Basic: Earnings before cumulative effect of accounting change $0.74 $0.11 $0.85 Cumulative effect of accounting change, net of tax -- -- -- Net earnings per share $0.74 $0.11 $0.85 Diluted: Earnings before cumulative effect of accounting change $0.73 $0.10 $0.83 Cumulative effect of accounting change, net of tax -- -- -- Net earnings per share $0.73 $0.10 $0.83 Weighted average shares used to compute earnings per share: Basic 1,055,165 1,055,165 Diluted 1,079,209 1,079,209 (1) Reflects operating results in accordance with U.S. generally accepted accounting principles (or GAAP). (2) Non-GAAP amounts exclude litigation-related special items, recurring charges related to the 1999 redemption of Genentech's Special Common Stock, and the cumulative effect of a change in accounting principle related to our adoption of Financial Accounting Standards Board Interpretation No. 46, "Consolidation of Variable Interest Entities," (or FIN 46), net of tax effects. (3) Represents the amortization of other intangible assets related to the 1999 redemption of Genentech's Special Common Stock. (4) Represents released accrual on a litigation matter; amounts received in 2003 related to the Amgen and Bayer litigation settlements; and also includes accrued interest and bond costs for 2004 and 2003 related to the City of Hope trial judgment. (5) "Other income, net" includes realized gains and losses from the sale of certain biotechnology equity securities and write-downs for other-than- temporary declines in the fair value of certain biotechnology debt and equity securities. In addition, "other income, net" includes interest income and interest expense. For further detail, refer to our web site at http://www.gene.com/. (6) Amount represents the cumulative effect of the accounting change, net of tax, related to our adoption of FIN 46 on July, 1 2003. (7) All share and per share amounts reflect the May 2004 two-for-one stock split of our Common Stock. Year Ended December 31, 2003 GAAP(1) Difference Non-GAAP(2) Revenues Product sales $2,621,490 $2,621,490 Royalties 500,903 500,903 Contract revenue 177,934 177,934 Total operating revenues 3,300,327 3,300,327 Costs and expenses: Cost of sales 480,123 480,123 Research and development 721,970 721,970 Marketing, general and administrative 794,845 794,845 Collaboration profit sharing 457,457 457,457 Recurring charges related to redemption 154,344 $(154,344)(3) -- Special items: litigation-related (113,127) 113,127(4) -- Total costs and expenses 2,495,612 (41,217) 2,454,395 Operating margin 804,715 41,217 845,932 Other income, net 92,791 92,791 Income before taxes and cumulative effect of accounting change 897,506 41,217 938,723 Income tax provision 287,324 16,366 303,690 Income before cumulative effect of accounting change 610,182 24,851 635,033 Cumulative effect of accounting change, net of tax (47,655) 47,655 (6) -- Net income $562,527 $72,506 $635,033 Earnings per share: (7) Basic: Earnings before cumulative effect of accounting change $ 0.59 $ 0.02 $ 0.61 Cumulative effect of accounting change, net of tax (0.05) 0.05 -- Net earnings per share $0.54 $0.07 $0.61 Diluted: Earnings before cumulative effect of accounting change 0.58 $0.02 $0.60 Cumulative effect of accounting change, net of tax (0.05) 0.05 -- Net earnings per share $0.53 $0.07 $0.60 Weighted average shares used to compute earnings per share(7): Basic 1,034,480 1,034,480 Diluted 1,057,620 1,057,620 GENENTECH, INC. CONDENSED CONSOLIDATED BALANCE SHEETS (in thousands) (unaudited) December 31, 2004 2003 Selected balance sheet data: Cash, cash equivalents and short-term investments $1,665,105 $1,511,772 Accounts receivable - product sales, net 627,353 315,097 Accounts receivable - royalties, net 217,482 184,163 Accounts receivable - other, net 77,743 74,831 Inventories 590,343 469,640 Restricted cash 682,000(4) -- Deferred tax asset 402,130(4) 121,885 Long-term marketable securities and other 1,115,327 1,422,886 Property, plant and equipment, net 2,091,404 1,617,912 Goodwill 1,315,019 1,315,019 Other intangible assets 668,391 810,810 Other long-term assets 88,156 812,714(4) Total assets 9,602,020 8,736,171 Total current liabilities 1,834,512(4) 873,031 Total liabilities 2,819,831 2,215,873 Total stockholders' equity 6,782,189 6,520,298 Year-to-date: Capital expenditures $649,858 $321,955 Total GAAP(1) depreciation and amortization expense 353,221 295,449 Less: redemption related amortization expense(3) (145,485) (154,344) Non-GAAP(2) depreciation and amortization expense $207,736 $141,105 (1) In accordance with U.S. generally accepted accounting principles (or AAP). (2) Non-GAAP amounts exclude amortization of other intangible assets elated to the 1999 redemption of Genentech's Special Common Stock. (3) Represents the amortization of other intangible assets related to the 999 redemption of Genentech's Special Common Stock. (4) Includes approximately $626 million in current liabilities, the elated deferred tax asset and restricted cash of $682 million in 2004 and 630 million in 2003 pledged to secure a bond for the City of Hope trial udgment, which was reclassified to current liabilities and assets, espectively. DATASOURCE: Genentech, Inc. CONTACT: Media, Debra Charlesworth, +1-650-225-2742, or Caroline Pecquet, +1-650-467-7078, or investor, Kathee Littrell, +1-650-225-1034, all of Genentech, Inc.

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