Cleveland BioLabs Chief Scientist Andrei Gudkov Discusses Recent Stem Cell Discovery and Partnership With Roswell Park Cancer In
23 Janvier 2007 - 7:18PM
PR Newswire (US)
CLEVELAND, Jan. 23 /PRNewswire-FirstCall/ -- Cleveland BioLabs,
Inc. (NASDAQ:CBLI) (BSE:CFB), today announced that Chief Scientist
Andrei Gudkov, Ph.D., D. Sci., was interviewed by Firestocks.com.
The video podcast can be accessed at the Cleveland BioLabs website
at http://www.cbiolabs.com/ or at http://www.firestocks.com/. Dr.
Gudkov highlighted the Company's recent discovery regarding its
Protectans 600 series of compounds being developed for radiation
protection. A single administration of CBLB612, the lead compound
in the Protectans 600 series, in healthy mice resulted in a
three-fold increase in the number of progenitor (originator) stem
cells in mouse bone marrow within 24 hours after administration.
Moreover, the number of these stem cells in peripheral blood was
increased 10-fold within four days of administration. This research
indicates that CBLB612 and other compounds in the 600 series are
not only potent stimulators of bone marrow stem cells, but also
cause their mobilization and proliferation throughout the blood.
Cleveland BioLabs's Protectans 600 series are modified factors of
Mycoplasmas. Protectan CBLB612 has demonstrated both radiation
protection and mitigation properties over a very broad time window
of use. In animal experiments, Protectan CBLB612 has produced
complete and sustained recovery of the hematopoietic (bone
marrow/blood production) system following lethal doses of
radiation. Dr. Gudkov also discussed the Company's strategic
research partnership with Roswell Park Cancer Institute to develop
the Company's cancer and radio- protectant drug candidates. Roswell
Park and various agencies of the state of New York will provide
Cleveland BioLabs with up to $5 million of non-dilutive funding.
Cleveland BioLabs will establish a major research/clinical facility
at the Roswell Park campus in Buffalo, NY, which will become the
foundation for its advanced research and clinical trials. The
Company will have an open- ended license to any basic research
conducted within or in collaboration with its Roswell Park
laboratory. Roswell Park Cancer Institute (RPCI), founded in 1898,
is a world-renowned cancer research hospital and the nation's first
cancer research, treatment and education center. RPCI is a member
of the prestigious National Comprehensive Cancer Network, an
alliance of the nation's leading cancer centers and is one of only
10 free-standing cancer centers in the nation. Other pending
developments noted in the interview include a Request for Proposal
(RFP) for medical radiation countermeasures to treat
gastrointestinal effects of Acute Radiation Syndrome (ARS) from The
Department of Defense (DoD). The DoD published a pre-solicitation
notice on December 20, 2006, indicating that this RFP will be
issued on or about January 10, 2007, with an anticipated contract
award on or about July 20, 2007. Cleveland BioLabs' lead radiation
protection compound, Protectan CBLB502, is currently being
developed to treat ARS and will be submitted to the DoD. CBLB502 is
effective as a radioprotectant when administered as little as 15
minutes prior to exposure and as a mitigator, if administered up to
one hour after exposure. CBLB502 is the first compound of its kind
to provide protection from both gastrointestinal and hematopoietic
(bone marrow/blood production) radiation-induced damage. In
addition, CBLB502 is stable in sterilized solution, not requiring
refrigeration, and could be injected using self-injectable devices,
which are the preferred delivery system in the field. Moreover, the
compound does not display toxicity at therapeutic doses. About
Cleveland BioLabs, Inc. Cleveland BioLabs, Inc. is a drug discovery
and development company leveraging its proprietary discoveries
about programmed cell death to treat cancer and protect normal
tissues from exposure to radiation and other stresses. The Company
has strategic partnerships with the Cleveland Clinic Foundation,
ChemBridge Corporation and the Armed Forces Research Radiobiology
Institute. To learn more about Cleveland BioLabs Inc., please visit
the company's website at http://www.cbiolabs.com/. This press
release contains forward-looking statements within the meaning of
the Private Securities Litigation Reform Act of 1995, including
without limitation, statements regarding potential benefits of the
research partnership. Forward-looking statements often are preceded
by words such as "believes," "expects," "may," "anticipates,"
"plans," "intends," "assumes," "will" or similar expressions.
Forward-looking statements reflect management's current
expectations, as of the date of this press release, and involve
certain risks and uncertainties. Our actual results could differ
materially from those anticipated in these forward-looking
statements as a result of various factors. Some of the factors that
could cause future results to materially differ from the recent
results or those projected in forward- looking statements include
the "Risk Factors" described in our Registration Statement on Form
SB-2/A filed with the Securities and Exchange Commission on
September 8, 2006. Contact: The Global Consulting Group Rachel
Levine T: (646) 284-9439 E: DATASOURCE: Cleveland BioLabs, Inc.
CONTACT: Rachel Levine of The Global Consulting Group,
+1-646-284-9439, or Web site: http://www.cbiolabs.com/
http://www.firestocks.com/
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