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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549 FORM 6-K
REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934
Date of report: September 12, 2024
Commission File Number: 001-39084
Innate Pharma SA
(Translation of registrant's name into English)
Innate Pharma SA
117 Avenue de Luminy—BP 30191
13009 Marseille, France
+ 33 (0) 4 30 30 30
(Address of principal executive office)
Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F. Form 20-F [ X ] Form 40-F [ ]
INCORPORATION BY REFERENCE
This Report on Form 6-K and Exhibit 99.2 to this Report on Form 6-K (excluding the Statutory Auditors' Review Report on the Half-Yearly Financial Information on page 43 of Exhibit 99.2) shall be deemed to be incorporated by reference into the registration statement on Form F-3 (File No. 333-276164) and registration statement on Form S-8 (File No. 333-282031) of Innate Pharma S.A. (including any prospectuses forming a part of such registration statements) and to be a part thereof from the date on which this report is furnished, to the extent not superseded by documents or reports subsequently filed or furnished.
EXHIBIT INDEX
Exhibit
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.
INNATE PHARMA S.A.
Date: September 12, 2024 By: /s/ Hervé Brailly Name: Hervé Brailly
Title: Interim Chief Executive Officer
INNATE PHARMA SA
HALF-YEAR FINANCIAL REPORT
JUNE 30, 2024
INNATE PHARMA S.A.
French société anonyme governed by an Executive Board and a Supervisory Board
with a share capital of 4,049,171.60 euros composed of
80,969,357 ordinary shares, and 14,075 preferred shares with a nominal value of 0.05 euros each
Registered office: 117, Avenue de Luminy, F-13009 Marseille, France
Registered with the Company and Trade Register of Marseille under number 424 365 336
The following interim condensed consolidated financial statements have been approved by the Executive Board of the Company on September 11, 2024, and have been subject to a limited review by our Statutory Auditors. They have been examined by the Supervisory Board of the Company on September 11, 2024.
SUMMARY
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Innate Pharma |Half-year financial report June 30, 2024 | 2
PRELIMINARY NOTE AND DISCLAIMER ON FORWARD-LOOKING INFORMATION AND RISK FACTORS
In this interim financial report, unless stated otherwise, the terms the “Company,” “Innate,” “Innate Pharma” and “Group” refer to Innate Pharma SA and its subsidiary.
This interim report contains certain forward-looking statements, including those within the meaning of applicable securities laws, including the Private Securities Litigation Reform Act of 1995. All statements other than those relating to present and historical facts and conditions contained in this interim report, including statements regarding the Company’s future results of operations and financial position, business strategy, plans and the Company’s objectives for research and development and future operations, are forward-looking statements. The use of certain words, including “anticipate,” “believe,” “can,” “could,” “estimate,” “expect,” “may,” “might,” “potential,” “expect” “should,” “will,” or the negative of these and similar expressions, is intended to identify forward-looking statements. Although the Company believes its expectations are based on reasonable assumptions, these forward-looking statements are subject to numerous risks and uncertainties, which could cause actual results to differ materially from those anticipated. These risks and uncertainties include, among other things, the uncertainties inherent in research and development, including related to safety, progression of and results from its ongoing and planned clinical trials and preclinical studies, review and approvals by regulatory authorities of its product candidates, the Company’s reliance on third parties to manufacture its product candidates, the Company’s commercialization efforts and the Company’s continued ability to raise capital to fund its development. For an additional discussion of risks and uncertainties, which could cause the Company's actual results, financial condition, performance or achievements to differ from those contained in the forward-looking statements, please refer to the Risk Factors (“Facteurs de Risque") section of the Universal Registration Document filed with the French Financial Markets Authority (“AMF”), which is available on the AMF website http://www.amf-france.org or on Innate Pharma’s website, and public filings and reports filed with the U.S. Securities and Exchange Commission (“SEC”), including the Company’s Annual Report on Form 20-F for the year ended December 31, 2023, and subsequent filings and reports filed with the AMF or SEC, or otherwise made public by the Company. References to the Company’s website and the AMF website are included for information only and the content contained therein, or that can be accessed through them, are not incorporated by reference into, and do not constitute a part of, this interim report.
In light of the significant uncertainties in these forward-looking statements, you should not regard these statements as a representation or warranty by the Company or any other person that the Company will achieve its objectives and plans in any specified time frame or at all. The Company undertakes no obligation to publicly update any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law.
Innate Pharma |Half-year financial report June 30, 2024 | 3
INNATE PHARMA AT A GLANCE
Innate Pharma SA (the “Company” and, with its subsidiary, referred to as the “Group”), is a global, clinical-stage biotechnology company developing immunotherapies for cancer patients. Its innovative approach aims to harness the innate immune system through therapeutic antibodies and its ANKET® (Antibody-based NK cell Engager Therapeutics) proprietary platform. Innate’s portfolio includes lead proprietary program lacutamab, developed in advanced form of cutaneous T cell lymphomas and peripheral T cell lymphomas, monalizumab developed with AstraZeneca in non-small cell lung cancer, as well as ANKET® multi-specific NK cell engagers to address multiple tumor types.
Innate Pharma is a trusted partner to biopharmaceutical companies such as Sanofi and AstraZeneca, as well as leading research institutions, to accelerate innovation, research and development for the benefit of patients.
Since its creation, the Company has suffered losses due to its research and development ("R&D") activities. The first half of 2024 generated a net loss of 24,764 thousand euros. As of June 30, 2024, shareholders' equity amounted to 28,796 thousand euros. Subject to receiving new milestone payments related to its collaboration agreements, the Company expects to incur additional losses until, if necessary, it can generate significant revenues from its drug candidates in development.
The Company’s future operations are highly dependent on a combination of factors, including: (i) the success of its R&D; (ii) regulatory approval and market acceptance of the Company’s future drug candidates; (iii) the timely and successful completion of additional financing; and (iv) the development of competitive therapies by other biotechnology and pharmaceutical companies. As a result, the Company is and should continue, in the short to mid-term, to be financed through partnership agreements for the development and commercialization of its drug candidates and through the issuance of new equity instruments and debt financing.
The activity of the Company is not subject to seasonal effects.
As of June 30, 2024, the Company had one wholly owned subsidiary: Innate Pharma, Inc., incorporated under the laws of Delaware in 2009.
Innate Pharma is based in Marseille, France and listed on Euronext in Paris and Nasdaq in the United States, and had 168 full time equivalent employees as of June 30, 2024.
Learn more about Innate Pharma at www.innate-pharma.com (please note the contents of the website are not incorporated into this report) .
Innate Pharma |Half-year financial report June 30, 2024 | 4
HALF-YEAR MANAGEMENT REVIEW
The key elements of Innate Pharma’s financial results for the first half of 2024 are as follows:
•Cash, cash equivalents and financial assets (current and non-current) amounting to €102.1m (million euros) as of June 30, 2024 (€102.3m as of December 31, 2023). At the same date, the financial liabilities amounted to €35.5m, including €26.6m of non-current liabilities (€39.9m as of December 31, 2023, including €31.0m of non-current financial liabilities).
•Revenue and other income amounting to €12.3m (€40.2m for the first half of 2023). This amount mainly results from collaboration and licensing revenue (€8.3m) and from research tax credit (€4.1m). Revenue from collaboration and licensing agreements mainly result from the agreements with AstraZeneca/Medimmune and Sanofi/Genzyme.
•Operating expenses amounting to €38.7m (€40.6m for the first half of 2023), of which 75.2% are related to research and development. Research and development expenses amount to €29.1m compared to €31.5m for the first half of 2023 and decrease by €2.4m, mainly explained by lower personnel and other R&D expenses by €2.2 millions (-15.4%). This decrease is due to an non-recurring amortization charge in the first half of 2023, related to the IPH5201 rights (full amortization of the additional €2.0 million invoice from Orega Biotech following the dosing of the first patient in the Phase 2 MATISSE clinical trial in June 2023). Additionally, direct R&D expenses, which slightly decreased by €0.2 million, remained at €17.1 million, with an acceleration in preclinical spending related to the Antibody-Drug Conjugates (ADC) program offsetting the decrease in expenses related to certain more mature clinical-stage programs.
•General expenses amounting to €9.6 million (compared to €9.1 million in the first half of 2023), an increase of €0.4 million. This increase is due to a €0.4 million decrease in personnel expenses linked to a reduction of the administrative staff (39 employees as of June 30, 2024, compared to 45 as of June 30, 2023), bringing personnel expenses to €4.0 million in the first half of 2024, more than offset by a €0.3 million increase in non-scientific and consulting fees, which amounts to €1.9 million in the first half of 2024, resulting from greater reliance on recruitment agencies, and (III) a €0.5 million increase in other expenses, mainly due to the derecognition of returned spaces in the first half of 2023 (as a reminder, on March 13, 2023, the Company signed an amendment to the lease of the 'Le Virage' building, aimed at reducing the area of leased premises) and the sale of related furniture during the same period, which led to an exceptional reduction in these charges in the first half of 2023.
•A net loss for the first half of 2024 amounting to €24.8m (compared to net income of €1.7m for the first half of 2023).
Note on change of accounting standards during the period
Application of the following amended standards is mandatory for the first time for the financial period beginning on January 1, 2024 and, as such, they have been adopted by the Company:
•Amendements to IAS 1 : Classification of liabilities with covenants;
•Amendements to IAS 7 and IFRS 7 : Supplier finance arrangements;
•Amendements to IFRS 16 : Lease liability in a sale and leaseback.
Those amended standards have no impact on the interim condensed consolidated financial statements.
Innate Pharma |Half-year financial report June 30, 2024 | 5
A.Revenue and other income
Revenue and other income resulted from collaboration and licensing agreements and government financing for research expenditure. They decreased by €27.9 million, to €12.3 million for the six months ended June 30, 2024, as compared to revenue and other income of €40.2 million for the six months ended June 30, 2023.
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in thousands of euro | June 30, 2024 | June 30, 2023 |
Revenue from collaboration and licensing agreements | 8,293 | 35,344 |
Government funding for research expenditures | 4,052 | 4,854 |
| | |
Revenue and other income | 12,345 | 40,198 |
Revenue from collaboration and licensing agreements
Revenue from collaboration and licensing agreements decreased by €27.1 million, to €8.3 million for the six months ended June 30, 2024, as compared to revenue from collaboration and licensing agreements of €35.3 million for the six months ended June 30, 2023. As a reminder, these revenues mainly resulted from the spreading of proceeds received in connection with the agreements signed with AstraZeneca in April 2015 and October 2018 with Sanofi in 2016 and 2022 and with Takeda in 2023. These revenues are recognized when the entity's performance obligation is met. They are recognized at a point in time or spread over time according to the percentage of completion of the work that the Company is committed to carry out under these agreements. Revenue from collaboration and licensing agreements are set forth in the table below:
| | | | | | | | |
(in thousands of euro) | June 30, 2024 | June 30, 2023 |
| | |
Proceeds from collaboration and licensing agreements | 7,396 | 34,729 |
of which monalizumab agreement (AstraZeneca) | 2,994 | 9,503 |
| | |
| | |
of which 2016 Sanofi agreement | 4,000 | 2,000 |
of which Sanofi agreement 2022 - ANKET IPH62 - Recognition of license initial payment and income related to the completion of work in line with the joint research program | 199 | 18,672 |
of which Sanofi agreement 2022 - ANKET IPH67 -Recognition of license initial payment, income related to the option exercise and income related to the completion of work in line with the joint research program | 203 | — |
of which Takeda agreement | — | 4,553 |
| | |
Invoicing of R&D costs (IPH5201 agreement) | 897 | 616 |
| | |
Revenue from collaboration and licensing agreements | 8,293 | 35,344 |
Proceeds from collaboration and licensing agreements
For monalizumab, these amounts result from the partial recognition of the $250.0 million non-refundable upfront payment and the $100 million milestone regarding the exercise of the option received in June 2015 and October 2018 from AstraZeneca. The additional payment of $50.0 million received from AstraZeneca in December 2020 triggered by the dosing of the first patient in the Phase 3 trial evaluating monalizumab was treated in full as a collaboration commitment ("collaboration liability" in the consolidated balance sheet) in view of the commitment linked to the agreement for the Phase 1/2 (co-financing) and Phase 3 studies (amendment signed in September 2020). Consequently, this additional payment has no impact on the transaction price.
In addition to these amounts, AstraZeneca made an additional payment of $50.0 million in June 2022, triggered by the treatment of the first patient in a second Phase 3 trial evaluating monalizumab in April 2022. This additional
Innate Pharma |Half-year financial report June 30, 2024 | 6
payment has been treated as a collaboration commitment ("collaboration liability" in the consolidated balance sheet) for an amount of $36.0 million in view to the contractual commitment linked to the Phase 1/2 studies (co-funding under the initial contract). The remaining $14.0 million was treated as a change in estimate of the transaction price, recognized in the income statement in line with the progress of the Phase 1/2 studies.
The amounts not yet recognized in revenue are classified as deferred revenue.
Proceeds related to monalizumab - AstraZeneca:
Revenue related to monalizumab decreased by €6.5 million, to €3.0 million for the six months ended June 30, 2024, as compared to €9.5 million for the six months ended June 30, 2023. This decrease is mainly due to the recognition of increased revenue in the first six months of 2023. Indeed, as of June 30, 2023, the Company had analyzed the cost base used to calculate the percentage of completion of Phase 1/2 trials in connection with their progress. This analysis led to a reduction in the cost base through a re-estimation of projected expenses. As a result, this adjustment on the cost base had a positive impact on the percentage of completion and led to the recognition of additional revenue of €5.9 million for the first half of 2023 which was not replicated in 2024.
As of June 30, 2024, the deferred revenue related to monalizumab is €2.0 million entirely classified as “Deferred revenue—Current portion” in connection with the progress of Phase 1/2 trials.
Proceeds related to Sanofi licensing and collaboration agreement (2016) :
Revenue related to the license and collaboration agreement signed with Sanofi in 2016 increased by €2.0 million, to €4.0 million for the six months ended June 30, 2024, as compared to €2.0 million for the six months ended June 30, 2023. On April 15, 2024, the Company announced the treatment of the first patient in the Phase 2 dose expansion part of the Sanofi-sponsored clinical trial evaluating NK Cell Engager SAR443579/ IPH6101 in various blood cancers. Under the terms of the 2016 agreement, this trial progress triggered a milestone payment of €4.0 million fully recognized in revenue during the first quarter of 2024. This amount was received by the Company on May 17, 2024.As a reminder, the Company announced that, in June 2023, the first patient was dosed in a Sanofi-sponsored Phase 1/2 clinical trial evaluating IPH6401/SAR'514 in relapsed or refractory Multiple Myeloma. As provided by the licensing agreement signed in 2016, Sanofi made a milestone payment of €2.0 million, fully recognized in revenue as of June 30, 2023. This amount was received by the Company on July 21, 2023.
Proceeds related to Sanofi research collaboration and licensing agreement (2022) :
As a reminder, on December 19, 2022, the Company announced that it had entered into a research collaboration and license agreement with Genzyme Corporation, a wholly-owned subsidiary of Sanofi (“Sanofi”) pursuant to which the Company granted Sanofi an exclusive license on the Innate Pharma's B7-H3 ANKET® program and options on two additional targets. On January 25, 2023, the Company announced the expiration of the waiting period under the Hart-Scott-Rodino (HSR) Antitrust Improvements Act of 1976 and the effectiveness of the licensing agreement as of January 24, 2023. Consequently, the Company received an upfront payment of €25.0 million in March 2023, including €18.5 million for the exclusive license, €1.5 million for the research activities and €5.0 million for the option on two additional targets.
The Company considers that the license to the B7-H3 technology is a right to use the intellectual property granted exclusively to Sanofi from the effective date of the agreement. As such, the €18.5 million upfront payment relating to the exclusive license was fully recognized in revenue as of June 30, 2023.
The Company will perform collaborative research activities for an initial estimated three-year period from the effective date of the collaboration, i.e. January 24, 2023. During this period, Sanofi and Innate will collaborate and work on research activities as defined in the research program described in the agreement. Consequently, the
Innate Pharma |Half-year financial report June 30, 2024 | 7
corresponding upfront payment of €1.5 million is recognized on a straight-line basis over the duration of the research activities that the Company has agreed to carry out. As a result, a €0.2 million has been recognized in revenue as of June 30, 2024 and June 30, 2023. Amounts not recognized in revenue are classified as deferred revenue—current portion for €0.4 million and deferred revenue—non-current portion for €0.5 million.
As previously announced, on December 19, 2023, the Company announced that Sanofi had exercised an option for one of the two targets. As a consequence, the Company recognized related income of €2.5 million as of December 31, 2023. This option exercise also resulted in a milestone payment of €15.0 million, including €13.3 million in respect of the exclusive license, which was fully recognized in income as of December 31, 2023, and €1.7 million in respect of research activities to be carried out by the Company, which will be recognized in income on a straight-line basis over the duration of the research work that the Company has agreed to carry out. Sanofi and Innate will collaborate and work on the research activities defined in the contractual research program. This work began during the first half of 2024. An amount of €0.2 million has been recognized in revenue as of June 30, 2024. Amounts not recognized in revenue are classified as deferred revenue—current portion for €0.4 million and deferred revenue—non-current portion for €1.1 million.
Proceeds related to Takeda licensing agreement (2023) :
Revenues under the license agreement signed with Takeda in 2023 are nil for the first half of 2024, compared to €4.6 million for the first half of 2023. On April 3, 2023, the Company announced that it has entered into an exclusive license agreement with Takeda under which Innate grants Takeda exclusive worldwide rights to research and develop antibody drug conjugates (ADC) using a panel of selected Innate antibodies against an undisclosed target, with a primary focus in Celiac disease. Takeda will be responsible for the future development, manufacture and commercialization of any potential products developed using the licensed antibodies. As such, the Company considers that the license granted is a right to use the intellectual property, which is granted fully and perpetually to Takeda. The agreement does not stipulate that Innate's activities will significantly affect the intellectual property granted during the life of the agreement. Consequently, the $5.0 million (or €4.6 million) initial payment, received by the Company in May 2023, was fully recognized in revenue as of June 30, 2023.
Invoicing of research and development costs - AstraZeneca:
Pursuant to our agreements with AstraZeneca, external research and development costs related to IPH5201 are equally shared between Innate Pharma and AstraZeneca, in accordance with the amendment signed in June 2022. These costs are invoiced back on a quarterly basis.
Revenue from invoicing of research and development costs for the six months ended June 30, 2024 increased by €0.3 million as compared to the six months ended June 30, 2023. The change between the two periods is mainly explained by the increase in research and development costs incurred by the Company under these agreements during the first half of 2024 in line with the clinical trial progress.
Government financing for research expenditures
The table below details government financing for research expenditures for the six months ended June 30, 2024 and 2023.
| | | | | | | | |
in thousands of euro | June 30, 2024 | June 30, 2023 |
| | |
Research tax credits | 4,050 | 4,854 (1) |
Grants | 2 | — |
Government financing for research expenditures | 4,052 | 4,854 |
Innate Pharma |Half-year financial report June 30, 2024 | 8
(1) As of June 30, 2023, the amount is mainly composed of (i) the research tax credit calculated and recognized for the first half of 2023 for an amount of €5.0 million from which is subtracted (ii) a provision amounting to €0.2 million relating to the additional provision in connection with the tax inspection carried out in 2022 by the French tax authorities relating to the 2019 and 2020 financial years, as well as the research tax credit and the accuracy of its calculation for the 2018 to 2020 financial years.
Government financing for research expenditures decreased by €0.8 million, or 16.5%, to €4.1 million for the six months ended June 30, 2024 as compared to €4.9 million for the six months ended June 30, 2023. This change is mainly due to the €1.5 million decrease in the research tax credit, resulting from (i) the absence of depreciation for IPH5201 rights in the first half of 2024, compared with the depreciation recognized in the first half of 2023 following the additional payment of €2.0 million to Orega Biotech following the dosing of the first patient in the MATISSE Phase 2 clinical trial, (ii) a decrease in amortization expense for the monalizumab intangible asset, which is nearing the end of its amortization period, and (iii) a reduction in eligible R&D personnel costs.
However, these decreases were offset by a €0.5 million increase in Research tax credits (Crédits d’impôt Recherches or “CIR”) from public and private R&D subcontracting expenses over the period included in the calculation of the research tax credit, due to the inclusion, for the first half of 2024, of R&D expenses incurred with a third party whose approval was under renewal as of June 30, 2023, and whose expenses had been excluded from eligible expenses for that period.
As a reminder, the research tax credit is calculated as 30% of the amount of research and development expenses, net of grants received, eligible for the research tax credit for the fiscal year.
B.Operating expenses
The table below presents our operating expenses for the six months periods ended June 30, 2024 and 2023:
| | | | | | | | |
in thousands of euro | June 30, 2024 | June 30, 2023 |
Research and development expenses | (29,076) | (31,453) |
General and administrative expenses | (9,582) | (9,144) |
Operating expenses | (38,657) | (40,597) |
Research and development expenses (R&D)
R&D expenses in the periods presented primarily relate to activities for the Company’s clinical and preclinical programs. Our research and development expenses are broken down as set forth in the table below :
Innate Pharma |Half-year financial report June 30, 2024 | 9
| | | | | | | | |
in thousands of euro | June 30, 2024 | June 30, 2023 |
Monalizumab | (69) | (604) |
Lacutamab | (5,224) | (6,719) |
IPH65 | (844) | (2,225) |
IPH5201 | (1,725) | (1,236) |
Other programs | (370) | (142) |
Sub-total programs in clinical development | (8,232) | (10,926) |
Sub-total programs in preclinical development | (8,838) | (6,339) |
Total direct research and development expenses | (17,070) | (17,265) |
Personnel expenses (including share-based payments) | (8,760) | (8,686) |
Depreciation and amortization | (643) | (3,044) |
Other expenses | (2,603) | (2,458) |
Personnel and other expenses | (12,005) | (14,188) |
Total research and development expenses | (29,076) | (31,453) |
R&D expenses decreased by €2.4 million, or 7.6%, to €29.1 million for the six months ended June 30, 2024, as compared to R&D of €31.5 million for the six months ended June 30, 2023.
R&D expenses represented a total of 75.2% and 77.5% of the total operating expenses for the six months ended June 30, 2024 and 2023, respectively.
Direct R&D expenses decreased by €0.2 million, or 1.1%, to €17.1 million for the six months ended June 30, 2024, as compared to an amount of €17.3 million for the six months ended June 30, 2023. This variation is mainly explained by a €2.5 million increase in expenses related to preclinical programs, particularly in the field of Antibody-Drug Conjugates (ADC), offset by a €2.7 million decrease in expenses related to clinical programs.
The variance relating to clinical programs is composed of the following items: (i) a €0.5 million increase related to recruitment costs for the Phase 2 MATISSE trial of the IPH5201 program, offset by (ii) a €1.4 million decrease in expenses for the IPH65 program, whose first patient was dosed in March 2024, (iii) a €1.5 million decrease in expenses for the lacutamab program, and (iv) a €0.5 million decrease in expenses related to the monalizumab program, decrease related to maturation of Phase I/II clinical trials under the collaboration with AstraZeneca.
Additionally, as of June 30, 2024, collaboration liabilities related to monalizumab and the agreements signed with AstraZeneca in April 2015, October 2018, and September 2020 amounted to €52.1 million, as compared to collaborations liabilities to €52.7 million as of December 31, 2023. This €0.5 million decrease mainly results from (i) net reimbursements of €2.4 million made to AstraZeneca in the first half of 2024 related to the co-funding of the monalizumab program, including the INTERLINK-1 Phase 3 trial launched in October 2020 and PACIFIC-9 launched in April 2022, and (ii) the increase in the collaboration commitment by €1.7 million due to exchange rate fluctuations observed during the period for the euro-dollar exchange rate.
Personnel and other expenses allocated to R&D decreased by €2.2 million, or 15.4%, to €12.0 million for the six months ended June 30, 2024, as compared to an amount of €14.2 million for the six months ended June 30, 2023. This decrease is mainly explained by amortization charges related to the IPH5201 rights, following the full amortization of the additional €2.0 million invoice from Orega Biotech after the dosing of the first patient in the Phase 2 MATISSE clinical trial in June 2023.
Innate Pharma |Half-year financial report June 30, 2024 | 10
General and administrative expenses:
General and administrative expenses increased by €0.4 million, or 4.8%, to €9.6 million for the six months ended June 30, 2024, as compared to general and administrative expenses of €9.1 million for the six months ended June 30, 2023. General and administrative expenses represent a total of 24.8% and 22.5% of the total operating expenses for the six months ended June 30, 2024 and 2023, respectively. The table below presents our general and administrative expenses by nature for the six months ended June 30, 2024 and 2023:
| | | | | | | | |
in thousands of euro | June 30, 2024 | June 30, 2023 |
Personnel expenses (including shared-based payments) | (4,001) | (4,367) |
Non scientific advisory and consulting | (1,934) | (1,662) |
| | |
Other expenses (1) | (3,648) | (3,116) |
Total general and administrative expenses | (9,582) | (9,144) |
(1) Other expenses are related to intellectual property, maintenance costs for laboratory equipment and our premises, depreciation and amortization and other selling, general and administrative expenses.
Personnel expense includes the compensation paid to our employees. They amounted €4.0 million for the six months ended June 30, 2024, as compared to €4.4 million for the six months ended June 30, 2023. The decrease of €0.4 million is mainly due to a reduction of administrative workforce.
Non-scientific advisory and consulting expenses mostly consist of auditing, accounting, legal fees and hiring services. Non-scientific advisory and consulting expenses increased by €0.3 million, or 16.4%, to €1.9 million for the six months ended June 30, 2024 as compared to €1.7 million for the six months ended June 30, 2023. This increase is mainly due to greater reliance on recruitment agencies.
The rise in other expenses of €0.5m mainly results from rent, maintenance, and upkeep costs (primarily related to property rentals; a exceptional effect related to the derecognition of returned spaces—as a reminder, on March 13, 2023, the Company signed an amendment to the lease of the "Le Virage" building, aimed at reducing the area of leased premises. The effective date of the lease amendment is March 15, 2023) as well as a €0.2 million increase in other net income and expenses (primarily related to the sale of office furniture following the reduction of leased spaces).
C.Net financial income (loss)
We recognized a net financial income of €1.5 million in the six months ended June 30, 2024 as compared to €2.1 million in the six months ended June 30, 2023. This variance mainly results from the unfavorable evolution of the dollar exchange rate and its impact on foreign exchange recorded during the first half of 2024, with a net foreign exchange loss of €0.9 million for the first half of 2024 as compared to a net foreign exchange gain of €0.4 million for the first half of 2023. The negative currency impact was offset by an increase in the fair value of certain financial instruments (net gain of €1.5 million for the six months ended June 30, 2024 as compared to a net gain of €1.0 million for the six months ended June 30, 2023) and by an increase in interest income of €1.3 million in first-half 2024 as compared to €1.0 million in first half of 2023.
The table below presents the components of our net financial income (loss) for the six months ended June 30, 2024 and 2023:
Innate Pharma |Half-year financial report June 30, 2024 | 11
| | | | | | | | |
(in thousands of euro) | June 30, 2024 | June 30, 2023 |
| | |
Interests on financial assets | 1,269 | 965 |
Change in valuation allowance on financial instruments | 1,471 | 1,044 |
Foreign exchange gains | 873 | 1,073 |
| | |
Financial income | 3,613 | 3,083 |
Foreign exchange losses | (1,763) | (642) |
| | |
Interest on financial liabilities | (300) | (324) |
| | |
Financial expenses | (2,064) | (966) |
Net financial income (loss) | 1,549 | 2,116 |
Our investment policy focuses on the absence of capital risk and, as far as possible, a guaranteed minimum performance.
For the six months ended June 30, 2024 and 2023, the foreign exchange gains and losses mainly result from the variance of the exchange rate between the Euro and the U.S. dollar on U.S. dollar-denominated cash and cash equivalents and financial assets. Unrealized losses on financial assets relate to unquoted instruments.
D.Balance sheet items
Cash, cash equivalents, short-term investments and non-current financial assets amounted to €102.1m as of June 30, 2024, as compared to €102.3m as of December 31, 2023. Net cash as of June 30, 2024 amounted to €82.9m (€83.5m as of December 31, 2023). Net cash is equal to cash, cash equivalents and short-term investments less current financial liabilities. Net cash is a non-IFRS financial indicator that is reviewed by the Company’s management and that the Company believes provides useful information to investors with respect to measuring cash resources that are available for strategic investment. Net cash is not defined by IFRS and is not a substitute for “cash and cash equivalents” as reported under IFRS. Management recognizes that the term net cash may be interpreted differently by other companies and under different circumstances.
As of June 30, 2024, the Company has been primarily financed by revenue from its collaboration, licensing agreements since 2011 (€579.1m in total, or $656.1m), and by issuing new shares (€306.4m in total excluding share-based payments and the costs the costs associated with capital increases). The Company has also benefited from the research tax credit (CIR) and fundings received from BPI France (ex-Oseo) in repayable advances not bearing interest and PTZI loan (interest free loan for Innovation). As of June 30, 2023, the Company is not liable for any reimbursement in respect of these reimbursable advances and PTZI loan. The Company also has bank borrowings of €34.9m, including €25.2m of State Guaranteed Loans (“Prêts Garantis par l’Etat”) as of June 30, 2024 and €9.6m loans subscribed with Société Générale for the construction of its head office as well as €0.6m of lease liabilities.
The research tax credit (Crédit d’Impôt Recherche) (the “Research Tax Credit” or “CIR”) granted by the French tax authorities in order to encourage companies to conduct technical and scientific research. Companies that can justify that these expenses meet the required criteria receive such grants in the form of a refundable tax credit that can be used for the payment of taxes due for the period in which the expense was incurred and for the next three years or refunded if necessary upon expiry of such a period. As a reminder, the Company has benefited from the early repayment of the Research Tax Credit (Crédit Impôt Recherche - CIR) until December 31, 2019. As of December 31 2019 and December 31, 2023, the Company no longer met the eligibility criteria for this status (criteria not met after year-end analysis). As a result, the CIR for 2019 and 2020 represented a receivable from the
Innate Pharma |Half-year financial report June 30, 2024 | 12
French Treasury, which was refunded to the Company in January 2024 for €16.7 million and July 2024 for €12.8 million. The CIR calculated in respect of 2023 and the first half of 2024 is recognized as a non-current receivable. For fiscal years 2021 and 2022, the Company met the definition of an SME under European Union criteria and was therefore entitled to early repayment of the CIR in 2022 in respect of the 2021 tax year and in July 2023 in respect of the 2022 tax year. Since its creation and at the date of this report, the Company has benefited from CIR reimbursements for a net amount of €128.9m.
The other key balance sheet items as of June 30, 2024 are as follows:
•Deferred revenue of €6.9m (including €4.1m booked as ‘Deferred revenue – non-current portion’) and collaboration liabilities amounting to €52.1m (including €41.9m booked as ‘Collaboration liabilities - non-current portion’) relating to the remainder of the initial payment from AstraZeneca not yet recognized as revenue or used as part of the co-financing of the monalizumab program with AstraZeneca;
•Receivables from the French government amounting to €26.6m in relation to the research tax credit for 2020, 2023 and the six-month period ended June 30, 2024;
•Shareholders’ equity of €28.8m including the net loss for the first half of 2024 of €24.8m.
E.Cash-flow items
As of June 30, 2024, cash and cash equivalents amounted to €70.0m, a decrease of €0.6m compared to December 31, 2023.
The following table sets forth cash flow data for the six months ended June 30, 2024 and 2023:
| | | | | | | | |
in thousands of euro | June 30, 2024 | June 30, 2023 |
Cash flows from / (used in) operating activities | 3,036 | (11,465) |
Cash flows from / (used in) investing activities | 932 | (246) |
Cash flows from / (used in) financing activities | (4,327) | (1,246) |
Effect of the exchange rate changes | (257) | 145 |
Net increase / (decrease) in cash and cash equivalents: | (615) | (12,811) |
Cash flows from / (used in) operating activities:
Net cash flow from operating activities increased by €14.5 million to €3.0 million for the six months ended June 30, 2024 as compared to net cash flow used in operating activities of €11.5 million for the six months ended June 30, 2023.
Net cash flow from operating activities for the first half of 2024 notably includes (i) the collection of €15.0 million in January 2024 following Sanofi's decision to exercise one of its two license option for an NK Cell Engager program in solid tumors, derived from the Company's ANKET® (Antibody-based NK Cell Engager Therapeutics) platform, pursuant to the terms of the research collaboration and license agreement signed in December 2022, (ii) the collection in May 2024 of €4.8 million (including value-added tax) the treatment of the first patient in the Phase 2 dose expansion part of the Sanofi-sponsored clinical trial evaluating NK Cell Engager SAR443579/ IPH6101 in various blood cancers and (iii) the repayment by the French Treasury of the research tax credit receivable relating to the 2019 financial year for an amount of €16.7 million during the first quarter of 2024, as well as the carry-back receivable for an amount of €0.3 million.
Innate Pharma |Half-year financial report June 30, 2024 | 13
As a reminder, for the first half of 2023, the net cash flow used in operating activities included (i) the €25.0 million upfront payment received from Sanofi in March 2023 following the effectiveness of the research collaboration and licensing agreement signed in December 2022 under which the Company granted Sanofi an exclusive license to Innate Pharma's B7-H3 ANKET® program and options on two additional targets, but also (ii) the €4.6 million ($5.0 million) upfront payment received from Takeda following the signing of an exclusive licensing agreement which the Company grants Takeda exclusive worldwide rights for the research and development of certain antibody drug conjugates (ADCs) (please refer to Note 20.Events after the reporting date).
Restated for these transactions linked to collaboration agreements and other non-recurring items such as the CIR refund, net cash flow used in operating activities for the first half of 2024 decreased by €7.3 million as compared to the first half of 2023. This change mainly results from lower net payments to suppliers and personnel costs.
Cash flows from / (used in) investing activities:
Net cash flow from investing activities for the six months ended June 30, 2024 was €0.9 million and was mainly composed of a disposal of a current financial instrument which generated a net cash collection of €1.2 million partially offset by acquisitions of property, plant and equipment and intangible assets for a net amount €0.3 million.
Net cash flow used in investing activities was €0.2 million for the six months ended June 30, 2023 and was mainly comprised of acquisitions of property, plant and equipment and intangible assets net of disposals.
The Company has not made any other significant investments in tangible, intangible or significant current and non-current financial assets during the first half of 2024 and 2023.
Cash flows from / (used in) financing activities:
Net cash flow used in financing activities for the six months ended June 30, 2024 was €4.3 million as compared to net cash flow used in financing activities of €1.2 million the six months ended June 30, 2023. These consumptions are mainly related to repayments of financial liabilities. Their increase over the period is related to the two State Guaranteed Loans, for which principal amortization began in the first quarter of 2024. As a reminder, the Company benefited from a one-year grace period in 2023, during which only interests and guarantee fees were paid.
F.Key events since January 1, 2024
•On March 6, 2024, the Company announced the treatment of the first patient in the Phase 1/2 trial evaluating IPH6501, a first-in-class CD20-targeting tetraspecific natural killer cell engager, from ANKET® platform, for the treatment of CD20-expressing B-cell Non-Hodgkin's Lymphomas.
•On April 15, 2024, the Company announced the treatment of the first patient in the Phase 2 dose expansion part of the Sanofi-sponsored clinical trial evaluating NK Cell Engager SAR443579/ IPH6101 in various blood cancers. Under the terms of the 2016 agreement, this trial progress triggered a milestone payment of €4.0 million fully recognized in revenue during the first quarter of 2024. This amount was received by the Company on May 17, 2024.
•On June 10, 2024, the Executive Board carried out a capital increase of €5,342 following the creation of 106,844 ordinary shares in the context of a company savings plan benefiting to the employees, including 68,744 ordinary shares issued free of charge (subscription). The capital increase was undertaken as follows : a creation of 68,744 free shares with a nominal value of €0.05 issued free of charge by deduction from the share premium, with a creation of 38,100 ordinary shares with a nominal value of €0.05 and an issue price of €2.45 (i.e an increase in share premium of €91,440).
Innate Pharma |Half-year financial report June 30, 2024 | 14
G.Nota
The interim condensed consolidated financial statements for the six-month period ended June 30, 2024 were established in accordance with IAS 34 standard adopted by European Union and as issued by the International Accounting Standards Board (IASB). They have been subject to a limited review by our Statutory Auditors and were approved by the Executive Board of the Company on September 11, 2024. They were reviewed by the Supervisory Board of the Company on September 11, 2024 and will not be submitted for approval to the general meeting of shareholders.
H.Main risks and uncertainties for the remaining six months of the fiscal year
Risk factors identified by the Company are presented in the item 3.D of the annual report filed with the SEC (20-F), on April 4, 2024 (SEC Accession No. 0001598599-24-000020). The main risks and uncertainties the Company may face in the six remaining months of the year are the same as the ones presented in the annual report available on the internet website of the Company.
Of note, the risks that are likely to arise during the remaining six months of the current financial year could also occur during subsequent years.
I.Related party transactions
Transactions with related parties during the periods under review are disclosed in Note 18 to the interim consolidated financial statements as of June 30,2024.
Innate Pharma |Half-year financial report June 30, 2024 | 15
INTERIM CONDENSED CONSOLIDATED FINANCIAL STATEMENTS AS OF JUNE 30, 2024
A.Interim Condensed Consolidated Statements of Financial Position (amounts in thousands of euro) | | | | | | | | | | | |
| Note | June 30, 2024 | December 31, 2023 |
Assets | | | |
| | | |
Current assets | | | |
Cash and cash equivalents | 4 | 69,990 | 70,605 |
Short-term investments | 4 | 21,809 | 21,851 |
Trade receivables and others | 5 | 19,795 | 55,557 |
Total current assets | | 111,594 | 148,012 |
| | | |
Non-current assets | | | |
Intangible assets | 6 | 119 | 416 |
Property and equipment | 7 | 5,748 | 6,322 |
Non-current financial assets | 4 | 10,350 | 9,796 |
Other non-current assets | | 85 | 87 |
Trade receivables and others - non-current | 5 | 14,478 | 10,554 |
Deferred tax asset | 16 | 9,123 | 9,006 |
Total non-current assets | | 39,903 | 36,181 |
| | | |
Total assets | | 151,497 | 184,193 |
Liabilities | | | |
| | | |
Current liabilities | | | |
Trade payables and others | 8 | 15,873 | 17,018 |
Collaboration liabilities – current portion | 13 | 10,248 | 7,647 |
Financial liabilities – current portion | 9 | 8,929 | 8,936 |
Deferred revenue – current portion | 13 | 2,799 | 5,865 |
Provisions - current portion | 17 | 375 | 171 |
Total current liabilities | | 38,224 | 39,637 |
| | | |
Non-current liabilities | | | |
Collaboration liabilities – non-current portion | 13 | 41,901 | 45,030 |
Financial liabilities – non-current portion | 9 | 26,574 | 30,957 |
Defined benefit obligations | 10 | 2,470 | 2,441 |
Deferred revenue – non-current portion | 13 | 4,116 | 4,618 |
Provisions - non-current portion | 17 | 294 | 603 |
Deferred tax liabilities | 16 | 9,123 | 9,006 |
Total non-current liabilities | | 84,478 | 92,656 |
| | | |
Shareholders’ equity | | | |
Share capital | 11 | 4,049 | 4,044 |
Share premium | 11 | 386,049 | 384,255 |
Retained earnings | | (336,893) | (329,323) |
Other reserves | | 354 | 495 |
Net income (loss) | | (24,764) | (7,570) |
Total shareholders’ equity | | 28,796 | 51,901 |
| | | |
Total liabilities and shareholders’ equity | | 151,497 | 184,193 |
Innate Pharma |Half-year financial report June 30, 2024 | 16
B.Interim Condensed Consolidated Statements of Income (Loss) (amounts in thousands of euro, except share and per share amounts)
| | | | | | | | | | | |
| Note | June 30, 2024 | June 30, 2023 |
| | | |
Revenue from collaboration and licensing agreements | 13 | 8,293 | 35,344 |
Government financing for research expenditures | 13 | 4,052 | 4,854 |
| | | |
| | | |
Revenue and other income | | 12,345 | 40,198 |
| | | |
Research and development expenses | 14 | (29,076) | (31,453) |
General and administrative expenses | 14 | (9,582) | (9,144) |
| | | |
Operating expenses | | (38,657) | (40,597) |
| | | |
| | | |
| | | |
Operating income (loss) | | (26,313) | (398) |
| | | |
Financial income | 15 | 3,613 | 3,083 |
Financial expenses | 15 | (2,064) | (966) |
| | | |
Net financial income (loss) | | 1,549 | 2,116 |
| | | |
Net income (loss) before tax | | (24,764) | 1,718 |
| | | |
Income tax expense | 16 | — | — |
| | | |
| | | |
| | | |
| | | |
| | | |
Net income (loss) | | (24,764) | 1,718 |
| | | |
Net income (loss) per share : | | |
Weighted average number of shares : | | 80,872,369 | 80,319,897 |
| | | |
(in € per share) | | | |
- Basic income (loss) per share | 20 | (0.31) | 0.02 |
- Diluted income (loss) per share | 20 | (0.31) | 0.02 |
| | | |
| | | |
| | | |
| | | |
C.Interim Condensed Consolidated Statements of Comprehensive Income (Loss) (amounts in thousands of euro)
| | | | | | | | |
| June 30, 2024 | June 30, 2023 |
Net income (loss) for the period: | (24,764) | 1,718 |
Items which will not reclassified in the consolidated statement of income (loss) | | |
Actuarial gains and (losses) related to defined benefit obligations | 116 | 101 |
Elements which will be reclassified in the consolidated statement of income (loss) | | |
Foreign currency translation gain (loss) | (257) | 146 |
Other comprehensive income (loss) | (141) | 247 |
Total comprehensive income (loss) | (24,905) | 1,965 |
Innate Pharma |Half-year financial report June 30, 2024 | 17
D.Interim Condensed Consolidated Statements of Cash Flows (amounts in thousands of euro)
| | | | | | | | | | | |
| Note | June 30, 2024 | June 30, 2023 |
Net income (loss) | | (24,764) | 1,718 |
Depreciation and amortization, net | 6, 7 | 1,142 | 3,645 |
Employee benefits costs | 10 | 145 | 83 |
Change in provision for charges | 18 | (105) | 507 |
Share-based compensation expense | 14 | 1,705 | 1,401 |
Change in fair value of financial assets | 4 | (992) | (1,044) |
Foreign exchange (gains) losses on financial assets | 4 | (524) | 288 |
Change in accrued interests on financial assets | 4 | (212) | (130) |
| | | |
| | | |
Disposal of property and equipment (scrapping) | | 18 | 591 |
Other profit or loss items with no cash effect | | 26 | 6 |
Operating cash flow before change in working capital | | (23,561) | 7,065 |
Change in working capital (1) | | 26,597 | (18,530) |
Net cash generated from / (used in) operating activities: | | 3,036 | (11,465) |
| | | |
Acquisition of property and equipment, net | 7.8 | (283) | (309) |
| | | |
| | | |
| | | |
| | | |
Disposal of other assets | | — | 66 |
Purchase of other assets | | — | (3) |
Disposal of current financial instruments | 4 | 1,215 | — |
| | | |
| | | |
Net cash generated from / (used in) investing activities: | | 932 | (246) |
Proceeds from the exercise / subscription of equity instruments | 11 | 93 | 348 |
| | | |
| | | |
Repayment of borrowings | 9 | (4,420) | (1,594) |
| | | |
Net cash generated / (used in) from financing activities: | | (4,327) | (1,246) |
Effect of the exchange rate changes | | (257) | 145 |
Net increase / (decrease) in cash and cash equivalents: | | (615) | (12,811) |
Cash and cash equivalents at the beginning of the year: | 4 | 70,605 | 84,225 |
Cash and cash equivalents at the end of the six-months period: | 4 | 69,990 | 71,414 |
(1) Change in working capital are detailed below:
Innate Pharma |Half-year financial report June 30, 2024 | 18
| | | | | | | | | | | | | | |
Change in working capital | Note | June 30, 2024 | December 31, 2023 | Variance |
Trade receivables and others - current and non-current portion (excluding receivables related to Property & equipment) | 5 | 34,273 | 66,111 | 31,838 |
Deferred revenue - current and non-current portion | 13 | (6,915) | (10,483) | (3,568) |
Trade payables and others (excluding payables related to capital expenditures) | 8 | (15,873) | (17,018) | (1,145) |
Collaboration liabilities - current and non-current portion | 13 | (52,149) | (52,677) | (528) |
Total change in Working Capital | | (40,664) | (14,067) | 26,597 |
| | | | | | | | | | | | | | |
Change in working capital | Note | June 30, 2023 | December 31, 2022 | Variance |
Trade receivables and others - current and non-current portion (excluding receivables related to Property & equipment) | 5 | 56,446 | 52,445 | (4,001) |
Deferred revenue - current and non-current portion | 13 | (11,024) | (14,481) | (3,457) |
Trade payables and others (excluding payables related to capital expenditures) | 8 | (16,991) | (20,911) | (3,919) |
Collaboration liabilities - current and non-current portion | 13 | (56,058) | (63,211) | (7,153) |
Total change in working capital | | (27,627) | (46,158) | (18,530) |
Innate Pharma |Half-year financial report June 30, 2024 | 19
E.Interim Consolidated Statement of Changes in Shareholders’ Equity (amounts in thousands of euro, except share data)
| | | | | | | | | | | | | | | | | | | | | | | | | | |
In thousands of euro, except for data share | Ordinary Shares | Preferred Shares | Share capital | Share premium | Retained earnings | Other comprehensive income | Net income (loss) | Total attributable to equity holders of the Company |
December 31, 2022 | 80,212,069 | 14,095 | 4,011 | 379,637 | (272,213) | 819 | (58,103) | 54,151 |
| | | | | | | | |
Net loss | — | — | — | — | — | — | 1,718 | 1,718 |
Actuarial gains on defined benefit obligations | — | — | — | — | — | 101 | — | 101 |
Foreign currency translation loss | — | — | — | — | — | 146 | — | 146 |
Total comprehensive gain/(loss) for the period | — | — | — | — | — | 247 | 1,718 | 1,965 |
| | | | | | | | |
Allocation of prior period income (loss) | — | — | — | — | (58,103) | — | 58,103 | — |
Exercise and subscription of equity instruments | 304,553 | — | 15 | 333 | — | — | — | 348 |
Shared-based payment | — | — | — | 1,400 | — | — | — | 1,400 |
June 30, 2023 | 80,516,622 | 14,095 | 4,027 | 381,371 | (330,315) | 1,064 | 1,718 | 57,863 |
| | | | | | | | |
December 31, 2023 | 80,860,563 | 14,090 | 4,044 | 384,255 | (329,323) | 495 | (7,570) | 51,901 |
| | | | | | | | |
Net income | — | — | — | — | — | — | (24,764) | (24,764) |
Actuarial loss on defined benefit obligations | — | — | — | — | — | 116 | — | 116 |
Foreign currency translation loss | — | — | — | — | — | (257) | — | (257) |
Total comprehensive gain/(loss) for the period | — | — | — | — | — | (141) | (24,764) | (24,905) |
| | | | | | | | |
Allocation of prior period income (loss) | — | — | — | — | (7,570) | — | 7,570 | — |
Exercise and subscription of equity instruments | 106,844 | — | 5 | 88 | — | — | — | 93 |
Shared-based payment | — | — | — | 1,706 | — | — | — | 1,706 |
June 30, 2024 | 80,967,407 | 14,090 | 4,049 | 386,049 | (336,893) | 354 | (24,764) | 28,796 |
Innate Pharma |Half-year financial report June 30, 2024 | 20
F.Interim Condensed Notes to the Consolidated Financial Statements
1.The Company and key events
1.1The company
Innate Pharma SA (the “Company” and, with its subsidiary, referred to as the “Group”), is a global, clinical-stage biotechnology company developing immunotherapies for cancer patients. Its innovative approach aims to harness the innate immune system through therapeutic antibodies and its ANKET® (Antibody-based NK cell Engager Therapeutics) proprietary platform. Innate’s portfolio includes lead proprietary program lacutamab, developed in advanced form of cutaneous T cell lymphomas and peripheral T cell lymphomas, monalizumab developed with AstraZeneca in non-small cell lung cancer, as well as ANKET® multi-specific NK cell engagers to address multiple tumor types. Innate Pharma is a trusted partner to biopharmaceutical companies such as Sanofi and AstraZeneca, as well as leading research institutions, to accelerate innovation, research and development for the benefit of patients.
Since its creation, the Company has suffered losses due to its research and development ("R&D") activities. The first half of 2024 generated a net loss of 24,764 thousand euros. As of June 30, 2024, shareholders' equity amounted to 28,796 thousand euros. Subject to receiving new milestone payments related to its collaboration agreements, the Company expects to incur additional losses until, if necessary, it can generate significant revenues from its drug candidates in development.
The Company’s future operations are highly dependent on a combination of factors, including: (i) the success of its R&D; (ii) regulatory approval and market acceptance of the Company’s future drug candidates; (iii) the timely and successful completion of additional financing; and (iv) the development of competitive therapies by other biotechnology and pharmaceutical companies. As a result, the Company is and should continue, in the short to mid-term, to be financed through partnership agreements for the development and commercialization of its drug candidates and through the issuance of new equity instruments and debt financing.
The activity of the Company is not subject to seasonal effects.
As of June 30, 2024, the Company had one wholly owned subsidiary: Innate Pharma, Inc., incorporated under the laws of Delaware in 2009. The subsidiary is consolidated according global integration.
Innate Pharma is based in Marseille, France and listed on Euronext Paris and Nasdaq in the United States., and had 168 full time equivalent employees as of June 30, 2024.
1.2Key events for the six-month period ended June 30, 2024
•On March 6, 2024, the Company announced the treatment of the first patient in the Phase 1/2 trial evaluating IPH6501, a first-in-class CD20-targeting tetraspecific natural killer cell engager, from ANKET® platform, for the treatment of CD20-expressing B-cell Non-Hodgkin's Lymphomas.
•On April 15, 2024, the Company announced the treatment of the first patient in the Phase 2 dose expansion part of the Sanofi-sponsored clinical trial evaluating NK Cell Engager SAR443579/ IPH6101 in various blood cancers. Under the terms of the 2016 agreement, this trial progress triggered a milestone payment of €4 million fully recognized in revenue during the first quarter of 2024. This amount was received by the Company on May 17, 2024.
•On June 10, 2024, the Executive Board carried out a capital increase of €5,342 following the creation of 106,844 ordinary shares benefiting the employees of the company, including 68,744 ordinary shares issued free of charge (subscription). The capital increase carried out can be broken as follow : a creation of 68,744
Innate Pharma |Half-year financial report June 30, 2024 | 21
free shares with a nominal value of €0.05 issued free of charge by deduction from the share premium, with a creation of 38,100 ordinary shares with a nominal value of €0.05 and an issue price of €2.45 (i.e an increase in share premium of €91,440).
2.Basis of presentation and statement of compliance
2.1Basis of preparation
The interim condensed consolidated financial statements as of June 30, 2024 and for the six-months period ended June 30, 2024 and 2023 and the related notes (together, the “interim condensed consolidated financial statements”) have been prepared under the responsibility of the management of the Company in accordance with the underlying assumptions of going concern as the Company’s loss-making situation is explained by the innovative nature of the products developed, therefore involving a multi-year research and development phase.
The interim condensed consolidated financial statements were closed by the Executive Board, approved and authorized by the Supervisory Board on September 11, 2024 upon recommendation of the Audit Committee on September 10, 2024.
They have been prepared in accordance with IAS 34, ‘Interim Financial Reporting’ as issued by the International Accounting Standard Board (“IASB”). Due to the listing of ordinary shares of the Company on Euronext Paris and in accordance with the European Union’s regulation No. 1606/2002 of July 19, 2002, the interim condensed consolidated financial statements are also prepared in accordance with IFRS, as adopted by the European Union (EU).For the presented periods, the differences between IFRS as issued by IASB and IFRS adopted by EU had no impact on the interim condensed consolidated financial statements.
The general accounting conventions were applied in accordance with the underlying assumptions, namely (i) going concern, (ii) permanence of accounting methods from one year to the next and (iii) independence of financial years, and in conformity with the general rules for the preparation and presentation of consolidated financial statements in accordance with International Financial Reporting Standards (“IFRS”). The interim condensed consolidated financial statements do not include all disclosures required for annual financial statements and should therefore be read in conjunction with the consolidated financial statements as of and for the year ended December 31, 2023.
The results of the operations for the six months ended June 30, 2024 are not necessarily indicative of the results to be expected for the year ending December 31, 2024 or for any other interim period or for any year in the future.
Except for number of shares and per share amounts, all amounts are expressed in thousands of euros, unless stated otherwise. Some amounts may be rounded for the calculation of financial information contained in the interim condensed consolidated financial statements. Accordingly, the totals in some tables may not be the exact sum of the preceding figures.
2.2Use of judgments and estimates
The preparation of financial statements in accordance with IFRS requires the Company to make certain estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities at the date of the financial statements, and the reported amounts of revenue and expenses during the reporting period.
Innate Pharma |Half-year financial report June 30, 2024 | 22
These estimates can be revised where the circumstances on which they are based change. The actual results may therefore differ from the estimates initially formulated. The estimates and judgments which are mainly used by the Company are detailed in note 2.w) of the appendix to the consolidated financial statements as of December 31, 2023 filed with SEC (20-F) on April 2, 2024. As of June 30, 2024, the Company has not identified any other significant estimates and judgments that could have an impact on the consolidated financial statements.
2.3Recently issued accounting standards and interpretations
Application of the following amended standards is mandatory for the first time for the financial period beginning on January 1, 2024 and, as such, they have been adopted by the Company:
•Amendments to IAS 1 : Classification of liabilities with covenants;
•Amendments to IAS 7 and IFRS 7 : Supplier finance arrangements;
•Amendments to IFRS 16 : Lease liability in a sale and leaseback.
Those amended standards have no impact on the interim condensed consolidated financial statements.
The Company has not opted for the early application of any standards whose application would be mandatory from subsequent financial years.
2.4Translation of transactions denominated in foreign currency
Foreign currency transactions are translated into the functionnal currency using the following exchange rates:
| | | | | | | | | | | | | | | | | | | | |
| June 30, 2023 | December 31, 2023 | June 30, 2024 |
€1 equals to | Average rate | Closing rate | Average rate | Closing rate | Average rate | Closing rate |
USD | 1.0806 | 1.0866 | 1.0813 | 1.1050 | 1.0813 | 1.0705 |
3.Management of financial risks
The Company did not identify other risks than the ones presented in the consolidated financial statements for the year ended December 31, 2023.
4.Cash, cash equivalents, short-term investments and non-current financial assets
| | | | | | | | |
(in thousands of euro) | June 30, 2024 | December 31, 2023 |
| | |
Cash and cash equivalents | 69,990 | 70,605 |
Short-term investments | 21,809 | 21,851 |
Cash, cash equivalents and short-term investments | 91,799 | 92,456 |
Non-current financial assets | 10,350 | 9,796 |
Cash, cash equivalents and financial assets | 102,149 | 102,252 |
Cash and cash equivalents are mainly composed of current bank accounts, interest-bearing accounts and fixed-term accounts and mutual funds units (with short-term maturities) held with various banking institutions.
As of June 30, 2024, the Company also holds shares in three mutual funds. The risk profiles of these funds are rated from 1 to 7 by the financial institution that manages and markets these funds (1 being the lowest risk
Innate Pharma |Half-year financial report June 30, 2024 | 23
profile).When the maturity of shares in mutual funds is longer than one year, they are classified as non-current financial instruments.
Non-current financial assets generally include a guarantee of capital at the maturity date (which is always longer than one year). These instruments are defined by the Company as financial assets at fair value through profit or loss and classified as non-current due to their maturity.
As of June 30, 2024 and December 31, 2023, the amount of cash, cash equivalents and financials assets denominated in US dollars amounted to €18,221 thousand and €20,798 thousand, respectively.
Changes in short-term investments and non-current financial assets for the six months ended June 30, 2023 and 2024 are the following:
| | | | | | | | | | | | | | | | | | | | | | | |
(in thousands of euro) | December 31, 2023 | Additions (1) | Deductions (2) | Variance of fair value through the consolidated statement of income (loss) | Variation of accrued interests | Foreign currency effect | June 30, 2024 |
Short-term investments | 21,851 | — | (1,215) | 438 | 212 | 524 | 21,810 |
Non-current financial assets | 9,796 | — | — | 553 | — | — | 10,350 |
Total | 31,647 | — | (1,215) | 991 | 212 | 524 | 32,160 |
| | | | | | | | | | | | | | | | | | | | | | | |
(in thousands of euro) | December 31, 2022 | Additions | Deductions | Variance of fair value through the consolidated statement of income (loss) | Variation of accrued interests | Foreign currency effect | June 30, 2023 |
Short-term investments | 17,260 | — | — | 271 | 232 | (288) | 17,475 |
Non-current financial assets | 35,119 | — | — | 772 | (102) | — | 35,790 |
Total | 52,379 | — | — | 1,043 | 130 | (288) | 53,265 |
(1) The additions correspond to both acquisitions and reclassifications of financial assets according to their maturity at the closing date.
(2) The deductions correspond to both disposals and reclassifications of financial assets according to their maturity at the closing date.
For the six months ended June 30, 2024 , variance of fair value through the consolidated statement of income (loss) is made of €553 thousand of unrealized gains on non-current financial assets and €438 thousand of unrealized gains on short-term investments. For the six months ended June 30, 2023, variance of fair value through the consolidated statement of income (loss) was made of €772 thousand of unrealized gains on non-current financial assets and €271 thousand of unrealized gains on short-term investments (see note 15).
Innate Pharma |Half-year financial report June 30, 2024 | 24
5.Trade receivables and others
| | | | | | | | |
(in thousands of euro) | June 30, 2024 | December 31, 2023 |
| | |
Other receivables | 97 | 104 |
| | |
Research tax credit(1) | 12,755 | 29,755 |
Other tax credits (2) | — | 361 |
Prepaid expenses (3) | 3,009 | 5,692 |
VAT refund | 583 | 1,037 |
Trade account receivables (4) | 393 | 15,233 |
Prepayments made to suppliers | 2,957 | 3,374 |
| | |
| | |
Receivables and others | 19,795 | 55,557 |
Research tax credit(1) | 13,850 | 9,800 |
Prepaid expenses (3) | 628 | 754 |
Receivables and others - non-current | 14,478 | 10,554 |
Trade receivables and others | 34,273 | 66,111 |
(1) The Research tax credit (CIR) is recognized as other operating income in the year to which the eligible research expenditure relates. The amount of €29,755 thousand recognized as current receivables as of December 31, 2023 comprises the research tax credit for the 2019 and 2020 tax years, for which the three year period has expired as of December 31, 2023. The CIR for 2019 was reimbursed in January 2024 for an amount of €16,737 thousand and to the CIR for the 2020 tax year of €13,018 thousand was collected in July 2024 for the amount of €12,755 thousand following the offset of the restated amount of €263 thousand (see note 8). The amount of €13,850 thousand recognized as a non-current receivable as of June 30, 2024 corresponds to the CIR for the 2023 tax year for the amount of €9,800 thousand and the amount of CIR calculated for the first half of 2024 for the amount of €4,050 thousand. Following the loss of SME status since December 31, 2023, the CIR for 2023 and 2024 represent non-current receivables from the French Treasury, which should in principle be offset against corporate income tax due for the following three years or refunded if necessary upon expiry of such a period.
(2) As of December 31, 2023, this amount mainly included a carry-back tax receivable of €333 thousand received in February 2024.
(3) As of June 30,2024, the prepaid expenses includes include an amount of €879 thousand (1,005 thousand as of December 31, 2023) relating to the guarantee fees in line with the two State Guaranteed Loans from Société Générale and BNP Paribas. Following the extension of these two loans repayment for an additional period, the full amount of the guarantee fee over the additional five-year period has been recognized as an operating expense in 2022. For each period-end, an adjustment is made through the prepaid accounts to reflect the fact that the expenses are related to the fiscal year (see note 9).
(4) As of December 31, 2023, the amount is mainly comprised of invoice of €15,000 thousand issued in December 2023 following the exercise of the license option by Sanofi. This amount was collected by the Company in January 2024.
The net book value of the receivables is considered to be a reasonable approximation of their estimated fair value. No valuation allowance was recognized on trade receivables and others as the credit risk of each debtor was considered as not significant.
Innate Pharma |Half-year financial report June 30, 2024 | 25
6.Intangible assets
| | | | | | | | | | | | | | |
(in thousands of euro) | Purchased licenses | Other intangible assets | In progress | Total |
| | | | |
| | | | |
January 1, 2023 | 1,556 | — | — | 1,556 |
Acquisitions | — | — | — | — |
Additional considerations(1) | 2,000 | — | — | 2,000 |
Disposals | — | — | — | — |
Amortizations(2) | (2,651) | — | — | (2,651) |
Transfers | — | — | — | — |
| | | | |
June 30, 2023 | 903 | — | — | 903 |
| | | | |
| | | | |
January 1, 2024 | 413 | 3 | — | 416 |
Acquisitions | — | — | — | — |
Additional considerations | — | — | — | — |
Disposals | — | — | — | — |
Amortizations(2) | (294) | (3) | — | (297) |
Transfers | — | — | — | — |
| | | | |
June 30, 2024 | 119 | — | — | 119 |
| | | | |
(1) This amount corresponds to the additional invoice received from Orega Biotech for the rights relating to IPH5201 following the first patient dosed in the Phase 2 MATISSE clinical trial in June 2023, in accordance to the agreement signed in 2019. This additional invoice is fully amortized as of June 30, 2023 and paid on July 2023.
(2) As of June 30, 2024, this amount included the amortization of rights related to the monalizumab for an amount of €294 thousand. As of June 30, 2023, this amount includes the amortization of the additional payment made to Orega Biotech in 2023 for and amount of €2,000 thousand and the amortization of rights related to the monalizumab for an amount of €651 thousand.
Monalizumab rights under the 2014 monalizumab (NKG2A) Novo Nordisk agreement
Since their acquisition, monalizumab rights are amortized on a straight-line basis over the anticipated residual duration of the Phase II trials. The Company has reassessed the anticipated residual duration of the Phase 2 trials as of June 30, 2024 and estimated that it would be fully amortized by 2024, which is the same estimation as of December 31, 2023, as a result of the completion of some trials and by modifying the estimated end dates relating to certain cohorts.
The net book values of the monalizumab rights were €119 thousand and €416 thousand as of June 30, 2024 and December 31, 2023, respectively.
IPH5201 (Anti-CD39) rights acquired from Orega Biotech
On January 4, 2016, the Company and Orega Biotech entered into an exclusive licensing agreement by which Orega Biotech granted the Company full worldwide rights to its program of first-in-class anti-CD39 checkpoint inhibitors. The upfront payment paid by the Company to Orega Biotech has been recognized as an intangible asset in the consolidated financial statements for the year ended December 31, 2016. Criteria relating to the first development milestone were reached in December 2016. Consequently, the amount of this milestone was recognized as an intangible asset in addition to the initial payment. In June 2019, the Company also paid Orega Biotech €7.0 million in relation to the anti-CD39 program as consideration following the collaboration and option agreement signed on October 22, 2018 with AstraZeneca regarding IPH5201. Under this agreement, the Company also paid in April and
Innate Pharma |Half-year financial report June 30, 2024 | 26
June 2020, respectively €2.5 and €0.2 million to Orega Biotech following the first Phase 1 dosing relating to IPH5201.
As a reminder, Orega Biotech claimed joint ownership of certain patents relating to IPH5201. The Company and Orega Biotech have resolved these claims in an arbitration proceeding, which decision was rendered in December 2021. As a result of this decision, the Company is required to pay a low-teen percentage of sub-licensing revenues received by the Company pursuant to its agreement with AstraZeneca regarding IPH5201. Following this arbitration decision, the Company paid in January 2022 an additional amount of €0.4 million to Orega. The Company announced on June 3, 2022 the progress of IPH5201 towards a study of Phase 2 in lung cancer, of which the Company will be a sponsor. In accordance with the amendment signed on June 1, 2022, the Company was eligible for a milestone payment of $5 million by AstraZeneca, received in August 2022 by the Company. In October 2022, the Company therefore paid an additional €0.6 million to Orega Biotech.
On June 26, 2023, the Company announced the treatment of the first patient in the Phase 2 MATISSE trial, conducted in collaboration with AstraZeneca and evaluating IPH5201 in early-stage lung cancer. As a consequence, the Company made an additional payment of €2.0 million to Orega Biotech in July 2023, in accordance with the agreement signed in 2019.
Avdoralimab (IPH5401) (anti-C5aR) rights acquired from Novo Nordisk A/S
At the agreement inception, an upfront payment of €40 million for acquired rights were recorded as intangible asset. As part of this agreement, an additional amount of €1.0 million was paid in October 2020 to Novo Nordisk A / S following the launch of the first avdoralimab Phase II trial. As avdoralimab is still in clinical trial, the acquired rights are classified as intangible asset in progress. They were subject to annual impairment test.
According to the agreement, the Company will pay additional payments according to the reach of specific steps. As of June 30, 2024, according to the uncertainty of these potential future payments, no liability was recognized.
Development costs incurred by the Company are recognized as research and development expenses.
As a reminder, during 2022 fourth quarter, the Company was informed by the sponsor of the Phase 2 clinical trial evaluating avdoralimab in inflammation in bullous pemphigoid ("BP") indication of its decision to discontinue said trial. Consequently, the Company decided in December 2022 to stop the development of avdoralimab in bullous pemphigoid ("BP") indication in inflammation, only indication supporting the recoverable amount of the asset as of December 31, 2021 (as well that as of June 30, 2022).
Following that decision, the Company applied IAS 36 "Impairment of assets" and assessed that there was an indication of impairment sufficiently significant to result in the full impairment of the intangible asset. This depreciation was recognized with regard to the estimate of the recoverable value of avdoralimab's intangible assets, based on expected future cash flows, as of December 2022, date of the decision. Thus, on decision date to stop the development of avdoralimab in bullous pemphigoid ("BP") indication in inflammation, avdoralimab rights were fully written down to their net book value, i.e €41,000 thousand.
Innate Pharma |Half-year financial report June 30, 2024 | 27
7.Property and equipment
| | | | | | | | | | | | | | | | | |
(in thousands of euro) | Lands and buildings | Laboratory equipment and other | In progress | Total | Of which right of use assets |
| | | | | |
January 1, 2023 | 4,242 | 4,298 | — | 8,542 | 6,423 |
Acquisitions | 31 | 279 | — | 310 | 79 |
Disposals (1) | (513) | (78) | — | (591) | (513) |
Depreciation | (323) | (670) | — | (993) | (428) |
Transfers | — | — | — | — | — |
| | | | | |
June 30, 2023 | 3,437 | 3,829 | — | 7,268 | 5,561 |
| | | | | |
| | | | | |
(in thousands of euro) | Lands and buildings | Laboratory equipment and other | In progress | Total | Of which right of use assets |
| | | | | |
January 1, 2024 | 2,958 | 3,378 | — | 6,322 | 5,055 |
Acquisitions | 15 | 267 | 3 | 285 | 37 |
Disposals | — | (18) | — | (18) | (18) |
Depreciation | (352) | (493) | — | (845) | (392) |
Transfers | — | — | — | — | — |
| | | | | |
June 30, 2024 | 2,621 | 3,134 | 3 | 5,748 | 4,682 |
(1) As a reminder, on March 13, 2023, the Company signed an amendment to the lease for the "Le Virage" building, reducing the surface area of the leased premises. The effective date of the lease amendment is March 15, 2023. As a result, and in accordance with IFRS 16, the impact on the consolidated balance sheet at the effective date of the lease amendment is as follows: write-off of a right of use (asset) of €0.5 million and a lease liability of €0.7 million.
8.Trade payables and others
| | | | | | | | |
(in thousands of euro) | June 30, 2024 | December 31, 2023 |
| | |
Suppliers (excluding payables related to capital expenditures) | 8,751 | 8,561 |
Tax and employee-related payables (1) | 6,013 | 7,021 |
Other payables (2) | 1,109 | 1,436 |
Trade payables and others (excluding payables related to capital expenditures) | 15,873 | 17,018 |
Payables related to capital expenditures | — | — |
Payables and others | 15,873 | 17,018 |
(1) As of December 31, 2023, tax and employee related payables included a liability accrual of €1.4 million following the notification received as part of the tax inspection relating to accounting and research tax credits for the 2018 to 2020 financial years. The liability recognized as of June 30, 2024 in connection with notification is €0.4 million following the payment of €0.7 million in February 2024 and the offset of €0.3 million against the 2020 research tax credit receivable initially recognized for €13.0 million and finally collected in July 2024 for €12.7 million.
(2) As of June 30, 2024 an December 31, 2023, this amount includes mainly the liability related to the payment of the guarantee fees on the two State Guaranteed Loans obtained from Société Générale and BNP Paribas in 2021 (see note 9).
Innate Pharma |Half-year financial report June 30, 2024 | 28
The book value of trade payables and others is considered to be a reasonable approximation of their fair value.
9.Financial liabilities
| | | | | | | | | | | | | | | | | | | | |
(in thousands of euro) | December 31, 2023 | Proceeds from borrowing | Proceeds from lease liabilities and other non cash effects | Repayments of borrowings/leases liabilities | Exchange rate variation (non cash) | June 30, 2024 |
State guaranteed loan Société Générale (1) | 20,000 | — | — | (2,432) | — | 17,568 |
State guaranteed loan BNP Paribas (1) | 8,700 | — | — | (1,070) | — | 7,630 |
State guaranteed loans - accrued interest | 14 | — | 13 | (14) | — | 13 |
| | | | | | |
Lease liabilities – Building "Le Virage" (3) | 375 | — | — | (121) | — | 254 |
Lease liabilities – Premises Innate Inc. | 246 | — | — | (47) | 8 | 207 |
Lease liabilities – Laboratory equipment | 109 | — | — | (83) | — | 26 |
Lease liabilities – Vehicles | 85 | — | 19 | (17) | — | 87 |
Lease liabilities - Printers | 18 | — | — | (4) | — | 13 |
Borrowing – Equipment | 99 | — | — | (28) | — | 71 |
Borrowing – Building (2) | 10,247 | — | 17 | (630) | — | 9,634 |
Total | 39,893 | — | 49 | (4,446) | 8 | 35,503 |
| | | | | | | | | | | | | | | | | | | | |
(in thousands of euro) | December 31, 2022 | Proceeds from borrowing | Proceeds from lease liabilities and other non cash effects | Repayments of borrowings/leases liabilities | Exchange rate variation (non cash) | June 30, 2023 |
State guaranteed loan Société Générale (1) | 20,000 | — | — | — | — | 20,000 |
State guaranteed loan BNP Paribas (1) | 8,700 | — | — | — | — | 8,700 |
State guaranteed loans - accrued interest | 15 | — | — | — | — | 15 |
Lease liabilities – Building "Le Virage" | 1,353 | — | (736) | (130) | — | 487 |
Lease liabilities – Premises Innate Inc. | 345 | — | — | (50) | 2 | 297 |
Lease liabilities – Laboratory equipment | 287 | — | — | (89) | — | 198 |
Lease liabilities – Vehicles | 33 | — | 48 | (13) | — | 70 |
Lease liabilities - Printers | 27 | — | — | (4) | — | 23 |
Borrowing – Equipment | 154 | — | — | (27) | — | 127 |
Borrowing – Building (2) | 11,338 | — | — | (602) | — | 10,736 |
Total | 42,251 | — | (689) | (916) | 2 | 40,658 |
(1) As a reminder, on January 5, 2022, the Company announced that it had obtained €28.7 million in non-dilutive financing in the form of two State Guaranteed Loans from Société Générale (€20.0 million) and BNP Paribas (€8.7 million). The Company received the funds related to these two loans on December 27 and 30, 2021 respectively. Both loans have an initial maturity of one year with an option to extend to five years usable from August, 2022. They are 90% guaranteed by the French government as part of the package of measures put in place by the French government to support companies during the COVID-19 pandemic. In August 2022, the Company has
Innate Pharma |Half-year financial report June 30, 2024 | 29
requested the extension of these two loans repayment for an additional period of five years starting in 2022 and including a one-year grace period. Consequently, the Company has obtained agreements from Société Générale and BNP Paribas. The effective interest rates applied to these contracts during the additional period are 1.56% and 0.95% for Société Générale and BNP Paribas loans, respectively, excluding insurance and guarantee fees, with an amortization exemption for the entire year 2023. During this grace period, the Company will only be liable for the payment of interest and the guarantee fees. The amortization of the two loans began in 2024 for a period of four years. The state guarantee fees amounts to €877 thousand and €379 thousand for Société Générale and BNP Paribas loans respectively.
(2) On July 3, 2017, the Company borrowed from the Bank “Société Générale” in order to finance the construction of its future headquarters. This loan amounting to a maximum of €15,200 thousand will be raised during the period of the construction in order to pay the supplier payments as they become due. As of December 31, 2018 and 2019, the loan was raised at an amount of €1,300 thousand.
The loan release period was limited to August 30, 2019. On August 30, 2019, the Company drew down the remaining portion of the €15,200 thousand loan granted, for an amount of €13,900 thousand. The reimbursement of the capital has begun in August 30, 2019 and will proceed until August 30, 2031 (12 years). Given the development of its portfolio and in particular the refocusing of its activities on research and development, the Company has for the time being suspended the project to build its new head office on the land acquired in Luminy. In the meantime, the loan will be used to finance several structuring projects (improvement of the information system, development of a commercial platform, development of additional premises rented, etc.). As of June 30, 2024, the remaining capital of the loan amounted to €9,617 thousand. The Company authorized collateral over financial “Société Générale” instruments amounting to €15,200 thousand. The security interest on the pledge financial instruments will be released in accordance with the following schedule: €4,200 thousand in July 2024, €5,000 thousand in August 2027 and €6,000 thousand in August 2031. Following the release of the pledge on the €4.2m financial instrument that had reached maturity, the company received this amount in July 2024.
This loan bears a fixed interest rate of 2.01%. It is subject to a covenant based on the assumption that the total cash, cash equivalents and current and non-current financial assets are at least equal to principal as of financial year end.
(3) As a reminder, on March 13, 2023, the Company signed an amendment to the lease for the "Le Virage" building, reducing the surface area of the leased premises. The effective date of the lease amendment is March 15, 2023. As a result, and in accordance with IFRS 16, the impact on the consolidated balance sheet at the effective date of the lease amendment is as follows: write-off of a right of use (asset) of €0.5 million and a lease liability of €0.7 million.
The table below shows the schedule for the contractual repayment of financial liabilities (being principal and interest payments) as of June 30, 2024:
Innate Pharma |Half-year financial report June 30, 2024 | 30
| | | | | | | | | | | | | | |
(in thousands of euro) | Within 1 year | From 2nd to 5th year included | Over 5 years | Total |
| | | | |
| | | | |
| | | | |
| | | | |
State guaranteed loan Société Générale | 5,167 | 12,918 | — | 18,086 |
State guaranteed loan BNP Paribas | 2,222 | 5,551 | — | 7,773 |
State guaranteed loans - accrued interest | — | — | — | — |
Lease liabilities – Building "Le Virage" | 254 | — | — | 254 |
Lease liabilities – Premises Innate Inc. | 100 | 111 | — | 211 |
Lease liabilities – Laboratory equipment | 26 | — | — | 26 |
Lease liabilities – Vehicles | 34 | 59 | — | 92 |
Lease liabilities - Printers | 9 | 4 | — | 13 |
Borrowing – Equipment | 57 | 14 | — | 71 |
Borrowing – Building | 1,545 | 5,587 | 3,210 | 10,342 |
Total financial liabilities | 9,414 | 24,245 | 3,210 | 36,869 |
10.Employee benefit
Defined benefit obligation
| | | | | | | | |
(in thousands of euro) | June 30, 2024 | December 31, 2023 |
| | |
Allowance for retirement defined benefit | 2,118 | 2,064 |
Allowance for seniority awards | 352 | 377 |
Defined benefit obligations | 2,470 | 2,441 |
Amounts recognized in the statement of financial position are determined as follows (in thousand euros):
| | | | | |
As of January 1, 2023 | 2,550 |
| |
| |
| |
| |
| |
Service cost | 312 |
Payments (benefits and contributions paid by the employer) | (27) |
Actuarial (gain) / loss | (394) |
| |
As of December 31, 2023 | 2,441 |
| |
Service cost | 166 |
Payments (benefits and contributions paid by the employer) | (22) |
Actuarial (gain) / loss | (116) |
| |
As of June 30, 2024 | 2,470 |
Discount rates used by the Company to evaluate retirement benefits were based on iBoxx Corporate AA. It was 3.60% and 3.20% as of June 30, 2024 and December 31, 2023, respectively.
In addition, the impact of the 2023 pension reform (including the raising of the retirement age) has been recognized as a plan amendment within the meaning of IAS 19, recognized in the income statement and balance sheet with no material impact at June 30, 2023.
Innate Pharma |Half-year financial report June 30, 2024 | 31
11.Capital
11.1Share capital
The Company manages its capital to ensure that the Company will be able to continue as a going concern while maximizing the return to shareholders through the optimization of the debt and equity balance.
As of June 30, 2024, the Company’s share capital amounted to €4,049,075 divided into (i) 80,967,407 ordinary shares, each with a nominal value of €0.05; (ii) 6,509 “2016” preferred shares, each with a nominal value of €0.05, and (iii) 7,581 “2017” preferred shares, each with a nominal value of €0.05, respectively, fully paid up.
Share capital does not include BSAs, BSAAR, AGAs and AGAPs that have been granted to certain investors or natural persons, both employees and non-employees of the Company, but not yet exercised.
On October 21, 2019 and December 30, 2019, the retention period for the “2016 free preferred shares” has ended. The number of ordinary shares to which the conversion of one preferred share entitle has been determined according to the achievement of the performance criteria. Holders of “2016” preferred shares” are entitled to vote at our shareholders’ meetings, to dividends and to preferential subscription rights, on the basis of the number of ordinary shares to which they are entitled if they convert their preferred shares.
In April 3, 2021, the retention period for the "2017 free preferred shares" has ended. The number of ordinary shares to which the conversion of one preferred share entitle has been determined according to the fulfillment of the performance criteria. According to these same performance criteria, the Executive Board of April 7, 2021 noted that the "2017 preferred shares" did not give right to any ordinary shares. The “2017 preferred shares” will not be redeemed by the Company and will remain incorporated into the capital, unless subsequently decided by the Executive Board. As the conversion is void, the "2017 preferred shares" no longer give the right to vote at our general meetings, nor to receive dividends.
In the six months ended June 30, 2024, a capital increase of €5,342 occurred as a result of the Executive Board decision on June 10, 2024, subsequent to the creation of 106,844 ordinary shares following the set-up of a company saving plan for the benefit of the Company’s employees, including 68,744 ordinary shares issued free of charge (top-up). This event led to a net capital increase of €5,342 and an increase in share premium of €88,003, broken down as a creation of 38,100 ordinary shares, with a nominal value of €0.05, for an issue price of €2.45, (ii) a creation of 68,744 ordinary shares, with a nominal value of €0.05.
11.2Treasury shares
The Company held 18,575 of its own shares as of June 30, 2024 and December 31, 2023, respectively.
11.3Share based payments
The Company has issued BSAs, BSAARs, AGAs and AGAPs as follows:
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Date | | Types | | Number of warrants issued as of 6/30/2024 | | Number of warrants void as of 6/30/2024 | | Number of warrants exercised as of 6/30/2024 | | Number of warrants outstanding as of 6/30/2024 | | Maximum number of shares to be issued as of 6/30/2024 | | Exercise price per share (in €) |
Sept. 9, 2011 | | BSAAR 2011 | | 650,000 | | 25,000 | | 625,000 | | — | | — | | 2.04 |
May 27, 2013 | | BSAAR 2012 | | 146,050 | | 12,250 | | 133,800 | | — | | — | | 2.04 |
July 1, 2015 | | BSAAR 2015 | | 1,050,382 | | 2,720 | | 1,940 | | 1,045,722 | | 1,045,722 | | 7.20 |
October 21, 2016 | | AGAP Management 2016-1 | | 2,000 | | 550 | | 250 | | 1,200 | | 156,000 | | - |
Innate Pharma |Half-year financial report June 30, 2024 | 32
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
October 21, 2016 | | AGAP Employees 2016-1 | | 2,486 | | 251 | | 172 | | 2,063 | | 268,190 | | - |
October 21, 2016 | | AGA Management 2016-1 | | 50,000 | | — | | 50,000 | | — | | — | | - |
December 30, 2016 | | AGAP Management 2016-2 | | 3,000 | | — | | — | | 3,000 | | 333,000 | | - |
December 30, 2016 | | AGA Management 2016-2 | | 250,000 | | — | | 250,000 | | — | | — | | - |
April 3,2018 | | AGAP Employees 2017-1 | | 5,725 | | 5,725 | | — | | — | | — | | - |
April 3,2018 | | AGAP Management 2017-1 | | 2,400 | | 2,400 | | — | | — | | — | | — |
April 3,2018 | | AGA Employees 2017 | | 114,500 | | 4,000 | | 110,500 | | — | | — | | — |
July 3, 2018 | | AGA Bonus 2018-1 | | 67,028 | | 469 | | 66,559 | | — | | — | | - |
November 20, 2018 | | AGAP Perf Employees 2018-1 | | 327,500 | | 224,375 | | 103,125 | | — | | — | | - |
November 20, 2018 | | AGAP Perf Management 2018-1 | | 260,000 | | 150,000 | | 110,000 | | — | | — | | - |
January 14, 2019 | | AGA Employees 2018 | | 90,650 | | 5,000 | | 85,650 | | — | | — | | - |
April 29, 2019 | | AGA New Members 2017-1 | | 25,000 | | — | | 25,000 | | — | | — | | - |
July 3, 2019 | | AGA Bonus 2019-1 | | 57,376 | | — | | 57,376 | | — | | — | | - |
July 13, 2020 | | AGA Bonus 2020-1 & 2 | | 79,861 | | 17,885 | | 61,976 | | — | | — | | - |
August 5, 2020 | | AGAP Employees 2020-1 | | 766,650 | | 681,420 | | 85,230 | | — | | — | | - |
August 5, 2020 | | AGAP Management 2020-1 | | 710,000 | | 580,000 | | 130,000 | | — | | — | | - |
July 22, 2021 | | AGA Bonus 2021-1 | | 125,748 | | — | | 125,748 | | — | | — | | - |
October 1, 2021 | | AGAP Employees 2021-1 | | 1,066,600 | | 290,800 | | — | | 775,800 | | 775,800 | | - |
October 1, 2021 | | AGAP Management 2021-1 | | 610,000 | | 130,000 | | — | | 480,000 | | 480,000 | | - |
February 12, 2022 | | AGA "Plan Epargne Entreprise" 2022 | | 138,960 | | — | | 138,960 | | — | | — | | — |
October 3, 2022 | | AGA Bonus 2022-1 | | 128,061 | | — | | 128,061 | | — | | — | | — |
December 12, 2022 | | AGA Perf Employees 2022-1 | | 1,371,500 | | 275,000 | | — | | 1,096,500 | | 1,096,500 | | — |
December 12, 2022 | | AGA Perf Management 2022-1 | | 550,000 | | — | | — | | 550,000 | | 550,000 | | — |
April 14, 2023 | | AGA "Plan Epargne Entreprise" 2023 | | 163,293 | | — | | 163,293 | | — | | — | | — |
November 2, 2023 | | AGA New members 2023-1 | | 25,000 | | — | | — | | 25,000 | | 25,000 | | — |
December 21, 2023 | | AGA Perf Employees 2023-1 | | 1,403,500 | | 66,250 | | — | | 1,337,250 | | 1,337,250 | | — |
December 21, 2023 | | AGA Perf Management 2023-1 | | 750,000 | | — | | — | | 750,000 | | 750,000 | | — |
February 15, 2024 | | AGA New members 2024-1 | | 25,000 | | — | | — | | 25,000 | | 25,000 | | — |
June 10, 2024 | | AGA "Plan Epargne Entreprise" 2024 | | 68,744 | | — | | 68,744 | | — | | — | | — |
July 21, 2020 | | Stock Options 2020-1 | | 102,000 | | 102,000 | | — | | — | | — | | - |
November 4, 2019 | | AGAP 2019 Employees 2019 | | 546,700 | | 375,150 | | 171,550 | | — | | — | | - |
November 4, 2019 | | AGAP 2019 Management 2019 | | 355,000 | | 207,500 | | 147,500 | | — | | — | | - |
July 29, 2011 | | BSA 2011-2 | | 225,000 | | 25,000 | | 200,000 | | — | | — | | 1.77 |
July 17, 2013 | | BSA 2013 | | 237,500 | | 12,500 | | 225,000 | | — | | — | | 2.36 |
July 16, 2014 | | BSA 2014 | | 150,000 | | — | | 75,000 | | 75,000 | | 75,000 | | 8.65 |
April 27, 2015 | | BSA 2015-1 | | 70,000 | | — | | — | | 70,000 | | 70,000 | | 9.59 |
July 1, 2015 | | BSA 2015-2 | | 14,200 | | — | | — | | 14,200 | | 14,200 | | 14.05 |
Innate Pharma |Half-year financial report June 30, 2024 | 33
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
September 20, 2017 | | BSA 2017 | | 37,000 | | — | | — | | 37,000 | | 37,000 | | 11.00 |
December 16, 2022 | | BSA 2022-1 | | 40,000 | | 31,740 | | — | | 8,260 | | 8,260 | | 2.31 |
December 15, 2023 | | BSA 2023-1 | | 50,000 | | 12,000 | | — | | 38,000 | | 38,000 | | 2.26 |
| | June 30, 2024 | | 12,914,414 | | 3,239,985 | | 3,340,434 | | 6,333,995 | | 7,084,922 | | |
12.Financial instruments recognized in the statement of financial position and related effect on the income statement
The following tables show the carrying amounts and fair values of financial assets and financial liabilities. The tables do not include fair value information for financial assets and financial liabilities not measured at fair value if the carrying amount is a reasonable approximation of fair value.
| | | | | | | | | | | | | | |
As of June 30, 2024 | Book value on the statement of financial position | Fair value through profit and loss (1) | Amortized cost (2) | Fair value |
Financial assets | | | | |
Non-current financial assets | 10,350 | 10,350 | — | 10,350 |
Trade receivables and others | 34,273 | — | 34,273 | 34,273 |
Short-term investments | 21,809 | 21,809 | — | 21,809 |
Cash and cash equivalents | 69,990 | 69,990 | — | 69,990 |
Total financial assets | 136,422 | 102,149 | 34,273 | 136,422 |
Financial liabilities | | | | |
Financial liabilities—non-current portion | 26,574 | — | 26,574 | 26,574 |
Financial liabilities—current portion | 8,929 | — | 8,929 | 8,929 |
Trade payables and others | 15,873 | — | 15,873 | 15,873 |
Total financial liabilities | 51,376 | — | 51,376 | 51,376 |
| | | | | | | | | | | | | | |
As of December 31, 2023 | Book value on the statement of financial position | Fair value through profit and loss (1) | Amortized Cost (2) | Fair value |
Financial assets | | | | |
Non-current financial assets | 9,796 | 9,796 | — | 9,796 |
Trade receivables and others | 66,111 | — | 66,111 | 66,111 |
Short-term investments | 21,851 | 21,851 | — | 21,851 |
Cash and cash equivalents | 70,605 | 70,605 | — | 70,605 |
Total financial assets | 168,363 | 102,252 | 66,111 | 168,363 |
Financial liabilities | | | | |
Financial liabilities—non-current portion | 30,957 | — | 30,957 | 30,957 |
Financial liabilities—current portion | 8,936 | — | 8,936 | 8,936 |
Trade payables and others | 17,018 | — | 17,018 | 17,018 |
Total financial liabilities | 56,911 | — | 56,911 | 56,911 |
(1) The fair value of financial assets classified as fair value through profit and loss corresponds to the market value of the assets, which are primarily determined using level 2 measurements.
(2) The book amount of financial assets and liabilities measured at amortized cost was deemed to be a reasonable estimation of fair value.
Innate Pharma |Half-year financial report June 30, 2024 | 34
In accordance with IFRS 7 and IFRS 13, financial instruments are presented in three categories based on a hierarchy of methods used to determine fair value:
Level 1: fair value determined based on quoted prices in active markets for assets or liabilities;
Level 2: fair value determined on the observable database for the asset or liability concerned either directly or indirectly;
Level 3: fair value determined on the basis of evaluation techniques based in whole or in part on unobservable data.
13.Revenue and other income
13.1Revenue from collaboration and licensing agreements
Revenues from collaboration and licensing agreements result from agreements signed with AstraZeneca, Sanofi and Takeda :
| | | | | | | | |
(in thousands of euro) | June 30, 2024 | June 30, 2023 |
| | |
Proceeds from collaboration and licensing agreements | 7,396 | 34,728 |
of which monalizumab agreement (AstraZeneca) | 2,994 | 9,503 |
| | |
| | |
of which 2016 Sanofi agreement | 4,000 | 2,000 |
of which Sanofi agreement 2022 - ANKET IPH62 - Recognition of license initial payment and income related to the completion of work in line with the joint research program | 199 | 18,672 |
of which Sanofi agreement 2022 - ANKET IPH67 -Recognition of license initial payment, income related to the option exercise and income related to the completion of work in line with the joint research program | 203 | — |
of which Takeda agreement | — | 4,553 |
| | |
Invoicing of R&D costs (IPH5201 agreement) | 897 | 616 |
| | |
Revenue from collaboration and licensing agreements | 8,293 | 35,344 |
a) Revenue recognition related to monalizumab AZ agreements and amendments
Change in deferred revenue relating to monalizumab agreement:
| | | | | |
(in thousands of euro) | Total |
As of December 31, 2022 | 14,481 |
| |
Revenue for the six months ended June 30, 2023 | (9,503) |
Transfer from / (to) collaboration liabilities | (283) |
As of June 30, 2023 | 4,695 |
| |
As of December 31, 2023 | 5,156 |
| |
Revenue for the six months ended June 30, 2024 | (2,994) |
Transfer from / (to) collaboration liabilities | (172) |
As of June 30, 2024 | 1,990 |
Innate Pharma |Half-year financial report June 30, 2024 | 35
Change in collaboration liabilities relating to monalizumab agreement:
| | | | | |
(in thousands of euro) | Total |
As of December 31, 2022 | 63,211 |
Additions | 283 |
Deductions | (7,436) |
As of June 30, 2023 | 56,058 |
| |
As of December 31, 2023 | 52,677 |
Additions | 1,891 |
Deductions | (2,419) |
As of June 30, 2024 | 52,149 |
b) Revenue recognition related to IPH5201 AstraZeneca collaboration and option agreement
Revenue related to IPH5201 for the six months ended June 30, 2024 and June 30, 2023 are nil. As a reminder, the Company signed on June 1, 2022 an amendment to the initial contract signed in October 2018. This amendment set the terms of the collaboration following AstraZeneca’s decision to advance IPH5201 to a Phase 2 study. The Company will conduct the study. Both parties will share the external cost related to the study and incurred by the Company and AstraZeneca will provide products necessary to conduct the clinical trial. Under the terms of this agreement, an amount of €897 thousand was rebilled to AstraZeneca during the first half of 2024 (€616 thousand during the first half of 2023).
c) Revenue related to IPH6401 - Sanofi (2016)
Revenue related to IPH6401 under the collaboration and license agreement signed with Sanofi is €4,000 thousand for the six months ended June 30, 2024, as compared to a revenue of €2,000 thousand as of June 30, 2023. During the period, the Company announced that the first patient was dosed in the Phase 2 dose expansion part of the Sanofi-sponsored clinical trial of SAR443579 / IPH6101, evaluating SAR443579 as a monotherapy for the treatment of blood cancers with high unmet needs. Under the terms of the 2016 research and licensing agreement with Sanofi, dosing of the first patient in the dose expansion part of the trial triggered a milestone payment to the Company of €4 million recognized as revenue as of June 30, 2024. This amount was received by the Company on May 17, 2024.
As a reminder, the Company announced that, in June 2023, the first patient was dosed in a Sanofi-sponsored Phase 1/2 clinical trial evaluating IPH6401/SAR'514 in relapsed or refractory Multiple Myeloma. Under the terms of the licensing agreement signed in 2016, Sanofi made a milestone payment of €2,000 thousand, fully recognized in revenue as of June 30, 2023. This amount was received by the Company on July 21, 2023.
d) Revenue related to Sanofi research collaboration and licensing agreement (2022)
On January 25, 2023, the Company announced the expiration of the waiting period under the Hart-Scott-Rodino (HSR) Antitrust Improvements Act of 1976 and the effectiveness of the licensing agreement as of January 24, 2023. Consequently, under the terms of such agreement, the Company received an upfront payment of €25,000 thousand in March 2023, including €18,500 thousand for the exclusive license, €1,500 thousand for the research work and €5,000 thousand for the two additional targets options. On December 19, 2023, the Company announced that Sanofi had exercised an option for one of the two targets. This option exercise also resulted in a
Innate Pharma |Half-year financial report June 30, 2024 | 36
milestone payment of €15,000 thousand, including €13,300 thousand in respect of the exclusive license, which was fully recognized in income as of December 31, 2023, and €1,700 thousand for the research activities to be carried out by the Company. The Company considers that the license to the B7-H3 technology is a right to use the intellectual property granted exclusively to Sanofi from the effective date of the agreement. As such, all upfront payments relating to the licenses granted have been recognized in the income statement representing an amount of €31,800 thousand, including €18.5 million relating to B7-H3 license and €13,300 thousand following the option exercised.
Change in deferred revenue relating to the 2022 research collaboration and licensing agreement :
| | | | | |
(in thousands of euro) | Total |
As of December 31, 2022 | — |
Additions (1) | 6,500 |
Deductions | (172) |
As of June 30, 2023 | 6,328 |
| |
| |
| |
| |
| | | | | |
(in thousands of euro) | Total |
As of December 31, 2023 | 5,327 |
Additions | — |
Deductions | (402) |
As of June 30, 2024 | 4,925 |
| |
| |
| |
| |
(1) The increase in deferred revenue relating to the 2022 research collaboration and licensing agreement with Sanofi between December 31, 2022 and June 30, 2023 mainly comprises (i) an upfront payment of €5,000 thousand relating to the granting of two options for exclusive licenses on Innate's intellectual property for the research, development, manufacturing and commercialization of NKCEs specifically targeting two preclinical molecules. The Company will recognize the related revenues either at the reporting date or three years after the effective date; as well as (ii) an amount of €1,500 thousand relating to research activities to perform in collaboration with Sanofi. The Company will recognize the related revenues on a straight-line basis over the duration of the research work to which the Company has agreed.
e) Schedule of variance of deferred revenue
| | | | | | | | | | | | | | | | | |
(in thousands of euro) | As of December 31, 2023 | Recognition in P&L | Proceeds | Transfer from / (to) collaboration liabilities | As of June 30, 2024 |
Monalizumab | 5,155 | (2,994) | — | (172) | 1,990 |
| | | | | |
Sanofi (2022) option | 2,500 | — | — | — | 2,500 |
Sanofi (2022) services | 2,826 | (402) | — | — | 2,424 |
| | | | | |
Total | 10,481 | (3,396) | — | (172) | 6,915 |
| | | | | | | | | | | | | | | | | |
(in thousands of euro) | As of December 31, 2022 | Recognition in P&L | Proceeds | Transfer from / (to) collaboration liabilities | As of June 30, 2023 |
Monalizumab | 14,481 | (9,503) | — | (283) | 4,696 |
| | | | | |
Sanofi (2022) option | — | — | 5,000 | — | 5,000 |
Sanofi (2022) services | — | (172) | 1,500 | — | 1,328 |
Total | 14,481 | (9,675) | 5,000 | (283) | 11,024 |
Innate Pharma |Half-year financial report June 30, 2024 | 37
13.2Government financing for research expenditures
The Company receives grants from the European Commission, French government and state organizations in several different forms:
•Research Tax Credits; and
• Investment and operating grants.
As of June 30, 2024 and 2023, an estimate of the research tax credit amount for the first half period is calculated on the basis of eligible expenses over the period.
The total amount for government financing for research expenditures recorded as other income in the income statement can be analysed as follows:
| | | | | | | | |
(in thousands of euro) | June 30, 2024 | June 30, 2023 |
| | |
Research tax credit | 4,050 | 4,854 |
Grant | 2 | — |
Government financing for research expenditures | 4,052 | 4,854 |
14.Operating expenses
| | | | | | | | | | | | | | | | | | | | |
(in thousands of euro) | June 30, 2024 | June 30, 2023 |
| R&D | G&A | Total | R&D | G&A | Total |
Subcontracting costs(1) | (15,585) | — | (15,585) | (15,857) | — | (15,857) |
Cost of supplies and consumable materials | (1,485) | (153) | (1,638) | (1,410) | (100) | (1,510) |
Personnel expenses other than share-based compensation | (7,532) | (3,470) | (11,002) | (7,781) | (3,871) | (11,652) |
Share-based compensation | (1,175) | (531) | (1,706) | (905) | (496) | (1,401) |
Personnel expenses | (8,707) | (4,001) | (12,708) | (8,686) | (4,367) | (13,053) |
Non-scientific advisory and consulting(2) | (124) | (1,934) | (2,058) | (532) | (1,662) | (2,194) |
Leasing and maintenance | (490) | (710) | (1,200) | (470) | (445) | (915) |
Travel expenses and meeting attendance | (272) | (151) | (423) | (180) | (143) | (323) |
Marketing, communication and public relations | (16) | (164) | (180) | (34) | (142) | (176) |
Scientific advisory and consulting(3) | (933) | — | (933) | (561) | — | (561) |
Other purchases and external expenses | (10) | (1,125) | (1,135) | (13) | (1,153) | (1,166) |
Depreciation and amortization | (643) | (503) | (1,146) | (3,044) | (601) | (3,645) |
Intellectual property expenses | (568) | (128) | (696) | (570) | (68) | (638) |
Other income and (expenses), net | (242) | (714) | (956) | (98) | (464) | (562) |
| | | | | | |
Total operating expenses | (29,076) | (9,582) | (38,657) | (31,453) | (9,144) | (40,597) |
(1)The Company subcontracts a significant part of its pre-clinical (pharmaceutical development, tolerance studies and other model experiments, etc.) and clinical operations (coordination of trials, hospital costs, etc.) to third parties.
Innate Pharma |Half-year financial report June 30, 2024 | 38
(2)Non-scientific advisory and consulting are services performed to support the general and administration activities of the Company, such as legal, accounting and audit fees as well as business development support.
(3)Scientific advisory and consulting expenses relate to consulting services performed by third parties to support the research and development activities of the Company.
14.1Personnel expenses other than share-based compensation
The line item amounted to €11,002 thousand and €11,652 thousand for the six months ended June 30, 2024 and 2023 respectively. The Company had 168 full time equivalent employees as of June 30, 2024, compared to 191 as of June 30, 2023. June 30, 2024, we had 135 employees, in research and development functions, compared to 151 employees as of June 30, 2023. Meanwhile, the administrative staff, totaled 39 people, compared to 45.
14.2Depreciation and amortization
As of June 30, 2023, this amount includes the amortization of the additional payment made to Orega Biotech in 2023 for and amount of €2,000 thousand and the amortization of rights related to the monalizumab for an amount of €651 thousand. As of June 30, 2024, this amount included the amortization of rights related to the monalizumab for an amount of €294 thousand . (see Note 6).
14.3Cost of suppliers and consumable materials
Cost of supplies and consumable materials consists mainly of the cost of procurement of the Company’s drug substance and/or drug product that is manufactured by third-parties, respectively.
15.Net financial income / (loss)
Net financial income (loss) can be analyzed as follows :
| | | | | | | | |
(in thousands of euro) | June 30, 2024 | June 30, 2023 |
| | |
Interests on financial assets | 1,269 | 965 |
Change in valuation allowance on financial instruments | 1,471 | 1,044 |
Foreign exchange gains | 873 | 1,073 |
| | |
Financial income | 3,613 | 3,083 |
Foreign exchange losses | (1,763) | (642) |
Unrealized losses on financial assets | — | — |
Interest on financial liabilities | (300) | (324) |
| | |
Financial expenses | (2,064) | (966) |
Net financial income (loss) | 1,549 | 2,116 |
For the six months ended June 30, 2024 and 2023, the foreign exchange gains and losses mainly result from the variance of the exchange rate between the Euro and the US dollar on US dollars denominated cash and cash equivalent and financial assets accounts.
Unrealized losses on financial assets relate to unquoted instruments, the fair value of which is determined using level 2 measurements.
Innate Pharma |Half-year financial report June 30, 2024 | 39
16.Income tax / (expense)
Due to the Company’s early stage of development, it is not probable that future taxable profit will be available against which the unused tax losses can be utilized. As a consequence, deferred tax assets are recognized up to deferred tax liabilities. The main temporary differences are related to the application of the IFRS 15 standard for fiscal years beginning on or after January 1, 2018, finance leases, provisions for pension commitments and tax loss carryforwards.
The Company did not recognize a current tax expense as of June 30, 2024 regarding a projected tax rate of nil as of December 31, 2024. As of June 30, 2024, the accumulated tax losses carryforwards of Innate Pharma SA were €483,570 thousand with no expiration date (same amount as of December 31, 2023). As of June 30, 2024, the accumulated tax losses carryforwards of Innate Pharma Inc was €15,181 thousand or $16,775 thousand (same amount as of December 31, 2023).
17.Commitments, contingencies and litigation
17.1Commitments
The Company has identified the following changes in off-balance sheet commitments since December 31, 2023:
•non-cancellable purchase commitments as of June 30, 2024 for a total of €6,612 thousand with various CMOs. These commitments are comprised of non-cancellable purchase orders placed during the first half of 2024 with contract manufacturing organizations (CMOs) for the supply of various services in relation with preclinical work for an amount of €3,020 thousand and clinical work for an amount of €3,592 thousand. The execution and billing of these services has not yet started at the date of this report.
•financial commitments with Société Générale in connection with the Company’s subscription of a loan in order to finance the construction of its future headquarters. As security for the loan, the Company pledged collateral in the form of financial instruments held at Société Générale amounting to €15.2 million. The security interest on the pledged financial instruments will be released in accordance with the following schedule: €4,200 thousand in July 2024, €5,000 thousand in August 2027 and €6,000 thousand in August 2031. At the date of this report, the first investment of €4,200 thousand had matured and the Company obtained its restitution in July 2024 for a total amount of €4,427 thousand, including interest. As of June 30, 2024, the remaining capital of this loan amounted to €9,617 thousand. Furthermore, under the loan, Innate is subject to a covenant that its total cash, cash equivalents and current and non-current financial assets as of each fiscal year end will be at least equal to the amount of outstanding principal under the loan. The Company was in compliance with this covenant as of December 31, 2023.
17.2Contingencies and litigations
The Company is exposed to contingent liabilities happening in the ordinary course of its activities. Each pre-litigation, known litigation or procedure in course the Company is involved in is analyzed at each closing date after consultation of legal counsel. There is no acknowledged litigation as of June 30, 2024.
17.3Provisions
Provisions amounted to €669 thousand and €774 thousand as of June 30, 2024 and December 31, 2023, respectively. As of June 30, 2024, they mainly consist of provision for charges amounting €586 thousand relating to the employer contribution in respect of the grants of employee equity instruments. In accordance with French
Innate Pharma |Half-year financial report June 30, 2024 | 40
social legislation, when a Company decides to provide its employees with shares bought back on the market, a provision has to be recognized upon the decision to allocate free shares that are spread over the vesting period when the plan conditions actions for employees when they join the Company at the end of the plan.
As a reminder, on March 16, 2022, the Company received a notice of a tax inspection by the French tax authorities and relating to the 2019 and 2020 financial years as well as to the research tax credit and the accuracy of its calculation for the 2018 to 2018 financial years 2020. On February 13, 2024, the Company was informed of the tax authorities conclusions regarding the tax inspection. A definitive amount of €1,367 thousand was determined and classified as short-term tax liabilities as of December 31, 2023. During the first half of 2024, the Company made a payment of €693 thousand.
18.Related party transactions
Members of the Executive Board and Other Executive Members
For each of the period presented, the following compensation was granted to the members of the Executive Committee of the Company and were recognized as expense:
| | | | | | | | |
(in thousands of euro) | June 30, 2024 | June 30, 2023 |
| | |
Personnel and other short-term employee benefits | 1,713 | 1,386 |
Extra pension benefits | 21 | 11 |
Share-based compensation | 519 | 408 |
Advisory fees | — | 318 |
Executive Board Members and other Executive Members compensation | 2,253 | 2,123 |
Personnel and other short-term employee benefits correspond to amounts included in personnel expenses for the six-month periods ended June 30, 2024 and 2023 respectively.
As of June 30, 2024, the Company has also recognized expenses totaling €184 thousand with companies in which a mandate is held by the identified related parties.
Members of the Supervisory Board
The Company recognized a provision of €163 thousand for attendance fees (jetons de presence) relating to the six months ended June 30, 2024. This amount includes the compensation for the Chairman of the Supervisory Board.
Related parties
Novo Nordisk A/S is a shareholder, Supervisory Board member and is related to the Company by three licensing agreements related to the drug candidates lirilumab, monalizumab and avdoralimab. Under the terms of the agreements, Novo Nordisk A/S is eligible to receive milestone payments as well as royalties on future sales. As of June 30, 2024, the Company has no liability to Novo Nordisk A/S.
AstraZeneca is a shareholder and is related to the Company through several collaboration and option licensing or license agreements for different drug candidates (monalizumab, avdoralimab and IPH5201). The payments between the two companies as well as the liabilities and receivables as of June 30, 2024 are as follows:
Innate Pharma |Half-year financial report June 30, 2024 | 41
| | | | | | | | |
| As of June 30,2024 |
(in thousands of euro) | Payments | Assets/Liabilities |
| | |
Collection (AstraZeneca to the Company) / Receivables | 1,657 | 394 |
Payments (the Company to AstraZeneca) / Liabilities | (3,342) | (3,926) |
Total | (1,685) | (3,532) |
Subsidiaries
The business relationships between the Company and its subsidiary are governed by intra-group and commercial agreements, concluded at market standard conditions on an arm’s length basis.
19.Income / (loss) per share
19.1Basic income / (loss) per share
Basic income / (loss) per share are calculated by dividing the net earnings attributable to equity holders of the Company by the weighted average number of ordinary shares in issue during the period.
| | | | | | | | |
| June 30, 2024 | June 30, 2023 |
| | |
Net income/(loss) | (24,764) | 1,718 |
Weighted average number of ordinary shares in circulation | 80,872,369 | 80,319,897 |
Basic income/(loss) per share (€ per share) | (0.31) | 0.02 |
19.2Diluted income / (loss) per share
Diluted income (loss) per share is calculated by dividing the net income (loss) attributable to equity holders of the Company by the weighted average number of ordinary shares in circulation during the corresponding period, increased by all dilutive potential common shares.
| | | | | | | | |
In thousands of euro, except for data share | June 30, 2024 | June 30, 2023 |
Net income/(loss) for the period | (24,764) | 1,718 |
Weighted average number of ordinary shares in circulation | 80,872,369 | 80,319,897 |
Adjustment for share instruments | 5,026,389 | 3,461,439 |
Diluted income/(loss) per share (€ per share) | (0.31) | 0.02 |
20.Events after the reporting date
On July 25, 2024, the Company received from Takeda a notice of termination of the Exclusive License agreement signed on March 31, 2023. This termination will be effective upon expiry of a 90-day notice period, i.e. on October 24, 2024.
Innate Pharma |Half-year financial report June 30, 2024 | 42
STATUTORY AUDITORS' REVIEW REPORT ON THE HALF-YEARLY FINANCIAL INFORMATION
This is a free translation into English of the statutory auditors’ review report on the half-yearly financial information issued in French and is provided solely for the convenience of English-speaking users. This report includes information relating to the specific verification of information given in the Group’s half-yearly management report. This report should be read in conjunction with, and construed in accordance with, French law and professional standards applicable in France.
To the Shareholders of INNATE PHARMA,
In compliance with the assignment entrusted to us by your Annual General Meeting and in accordance with the requirements of article L.451-1-2 III of the French Monetary and Financial Code (“Code monétaire et financier”), we hereby report to you on:
•the review of the accompanying condensed half-yearly consolidated financial statements of Innate Pharma, for the period from January 1, 2024 to June 30, 2024;
•the verification of the information presented in the half-yearly management report.
These condensed half-yearly consolidated financial statements are the responsibility of the Executive Board. Our role is to express a conclusion on these financial statements based on our review.
Conclusion on the financial statements
We conducted our review in accordance with professional standards applicable in France. A review of interim financial information consists of making inquiries, primarily of persons responsible for financial and accounting matters, and applying analytical and other review procedures. A review is substantially less in scope than an audit conducted in accordance with professional standards applicable in France and consequently does not enable us to obtain assurance that we would become aware of all significant matters that might be identified in an audit. Accordingly, we do not express an audit opinion.
Based on our review, nothing has come to our attention that causes us to believe that the accompanying condensed half-yearly consolidated financial statements are not prepared, in all material respects, in accordance with IAS 34- standard of the IFRSs as adopted by the European Union applicable to interim financial information.
Specific verification
We have also verified the information presented in half-yearly management report on the condensed half-yearly consolidated financial statements subject to our review.
We have no matters to report as to its fair presentation and consistency with the condensed half-yearly consolidated financial statements.
Neuilly-sur-Seine and Paris-La Défense, September 11, 2024
The Statutory Auditors
French original signed by
PricewaterhouseCoopers Audit Deloitte & Associés
Cédric Mazille Stéphane MENARD
Innate Pharma |Half-year financial report June 30, 2024 | 43
DECLARATION BY THE PERSON RESPONSIBLE FOR THIS HALF-YEAR FINANCIAL REPORT
I hereby declare, to the best of my knowledge, that the condensed consolidated interim financial statements for the six months ended June 30, 2024 have been prepared in accordance with applicable accounting standards and give a true and fair view of the assets, liabilities, financial position and results of the Company and the subsidiaries included in the consolidation, and that the half year management reviews stated on page 5 gives a fair description of the material events that occurred in the first six months of the financial year and their impact on the interim financial statements, as well as a description of the principal risks and uncertainties for the remaining six months of the year, along with the principal transactions with related parties.
Chairman of the Executive Board
Mr Hervé Brailly
Innate Pharma |Half-year financial report June 30, 2024 | 44
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Interim Condensed Consolidated Statements of Financial Position - EUR (€) € in Thousands |
Jun. 30, 2024 |
Dec. 31, 2023 |
Current assets |
|
|
Cash and cash equivalents |
€ 69,990
|
€ 70,605
|
Short-term investments |
21,809
|
21,851
|
Trade receivables and others |
19,795
|
55,557
|
Total current assets |
111,594
|
148,012
|
Non-current assets |
|
|
Intangible assets |
119
|
416
|
Property and equipment |
5,748
|
6,322
|
Non-current financial assets |
10,350
|
9,796
|
Other non-current assets |
85
|
87
|
Trade receivables and others - non-current |
14,478
|
10,554
|
Deferred tax asset |
9,123
|
9,006
|
Total non-current assets |
39,903
|
36,181
|
Total assets |
151,497
|
184,193
|
Current liabilities |
|
|
Payables and others |
15,873
|
17,018
|
Collaboration liabilities – current portion |
10,248
|
7,647
|
Financial liabilities – current portion |
8,929
|
8,936
|
Deferred revenue – current portion |
2,799
|
5,865
|
Provisions - current portion |
375
|
171
|
Total current liabilities |
38,224
|
39,637
|
Non-current liabilities |
|
|
Collaboration liabilities – non-current portion |
41,901
|
45,030
|
Financial liabilities – non-current portion |
26,574
|
30,957
|
Defined benefit obligations |
2,470
|
2,441
|
Deferred revenue – non-current portion |
4,116
|
4,618
|
Provisions - non-current portion |
294
|
603
|
Deferred tax liabilities |
9,123
|
9,006
|
Total non-current liabilities |
84,478
|
92,656
|
Shareholders’ equity |
|
|
Share capital |
4,049
|
4,044
|
Share premium |
386,049
|
384,255
|
Retained earnings |
(336,893)
|
(329,323)
|
Other reserves |
354
|
495
|
Net income (loss) |
(24,764)
|
(7,570)
|
Total shareholders’ equity |
28,796
|
51,901
|
Total liabilities and shareholders’ equity |
€ 151,497
|
€ 184,193
|
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v3.24.2.u1
Interim Condensed Consolidated Statements of Income (Loss) - EUR (€) € in Thousands |
6 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
Profit (loss) [abstract] |
|
|
Revenue from collaboration and licensing agreements |
€ 8,293
|
€ 35,344
|
Government financing for research expenditures |
4,052
|
4,854
|
Revenue and other income |
12,345
|
40,198
|
Research and development expenses |
(29,076)
|
(31,453)
|
General and administrative expenses |
(9,582)
|
(9,144)
|
Operating expenses |
(38,657)
|
(40,597)
|
Operating income (loss) |
(26,313)
|
(398)
|
Financial income |
3,613
|
3,083
|
Financial expenses |
(2,064)
|
(966)
|
Net financial income (loss) |
1,549
|
2,116
|
Net income (loss) before tax |
(24,764)
|
1,718
|
Income tax expense |
0
|
0
|
Net income (loss) |
€ (24,764)
|
€ 1,718
|
Net income (loss) per share : |
|
|
Weighted average number of shares, basic (in shares) |
80,872,369
|
80,319,897
|
Weighted average number of shares, diluted (in shares) |
80,872,369
|
80,319,897
|
Basic income (loss) per share (in EUR per share) |
€ (0.31)
|
€ 0.02
|
Diluted income (loss) per share (in EUR per share) |
€ (0.31)
|
€ 0.02
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v3.24.2.u1
Interim Condensed Consolidated Statements of Cash Flows - EUR (€) € in Thousands |
6 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
Statement of cash flows [abstract] |
|
|
|
Net income (loss) |
|
€ (24,764)
|
€ 1,718
|
Depreciation and amortization, net |
|
1,142
|
3,645
|
Employee benefits costs |
|
145
|
83
|
Change in provision for charges |
|
(105)
|
507
|
Share-based compensation expense |
|
1,705
|
1,401
|
Change in fair value of financial assets |
|
(992)
|
(1,044)
|
Foreign exchange (gains) losses on financial assets |
|
(524)
|
288
|
Change in accrued interests on financial assets |
|
(212)
|
(130)
|
Disposal of property and equipment (scrapping) |
|
18
|
591
|
Other profit or loss items with no cash effect |
|
26
|
6
|
Operating cash flow before change in working capital |
|
(23,561)
|
7,065
|
Change in working capital |
[1] |
26,597
|
(18,530)
|
Net cash generated from / (used in) operating activities: |
|
3,036
|
(11,465)
|
Acquisition of property and equipment, net |
|
(283)
|
(309)
|
Disposal of other assets |
|
0
|
66
|
Purchase of other assets |
|
0
|
(3)
|
Disposal of current financial instruments |
|
1,215
|
0
|
Net cash generated from / (used in) investing activities: |
|
932
|
(246)
|
Proceeds from the exercise / subscription of equity instruments |
|
93
|
348
|
Repayment of borrowings |
|
(4,420)
|
(1,594)
|
Net cash generated / (used in) from financing activities: |
|
(4,327)
|
(1,246)
|
Effect of the exchange rate changes |
|
(257)
|
145
|
Net increase / (decrease) in cash and cash equivalents: |
|
(615)
|
(12,811)
|
Cash and cash equivalents at the beginning of the year: |
|
70,605
|
84,225
|
Cash and cash equivalents at the end of the six-months period: |
|
69,990
|
71,414
|
Change in working capital |
|
|
|
Trade receivables and others - current and non-current portion (excluding receivables related to Property & equipment) |
|
34,273
|
56,446
|
Trade receivables and others - current and non-current portion (excluding receivables related to Property & equipment) |
|
31,838
|
(4,001)
|
Deferred revenue - current and non-current portion |
|
(6,915)
|
(11,024)
|
Deferred revenue - current and non-current portion, variance |
|
(3,568)
|
(3,457)
|
Trade payables and others (excluding payables related to capital expenditures) |
|
(15,873)
|
(16,991)
|
Trade payables and others (excluding payables related to capital expenditures), variance |
|
(1,145)
|
(3,919)
|
Collaboration liabilities - current and non-current portion |
|
(52,149)
|
(56,058)
|
Collaboration liabilities - current and non-current portion, variance |
|
(528)
|
(7,153)
|
Total change in working capital |
|
(40,664)
|
(27,627)
|
Total change in working capital, variance |
[1] |
€ 26,597
|
€ (18,530)
|
|
|
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v3.24.2.u1
Interim Consolidated Statement of Changes in Shareholders’ Equity - EUR (€)
|
Total |
Share capital |
Share premium |
Retained earnings |
Other comprehensive income |
Net income (loss) |
Ordinary Shares
Share capital
|
Preferred Shares
Share capital
|
Balance at beginning of period (in shares) at Dec. 31, 2022 |
|
|
|
|
|
|
80,212,069
|
14,095
|
Balance at beginning of period at Dec. 31, 2022 |
€ 54,151,000
|
€ 4,011,000
|
€ 379,637,000
|
€ (272,213,000)
|
€ 819,000
|
€ (58,103,000)
|
|
|
Net income (loss) |
1,718,000
|
|
|
|
|
1,718,000
|
|
|
Actuarial gains on defined benefit obligations |
101,000
|
|
|
|
101,000
|
|
|
|
Foreign currency translation loss |
146,000
|
|
|
|
146,000
|
|
|
|
Total comprehensive income (loss) |
1,965,000
|
|
|
0
|
247,000
|
1,718,000
|
|
|
Allocation of prior period income (loss) |
0
|
|
|
(58,103,000)
|
|
58,103,000
|
|
|
Exercise and subscription of equity instruments (in shares) |
|
|
|
|
|
|
304,553
|
|
Exercise and subscription of equity instruments |
348,000
|
15,000
|
333,000
|
|
|
|
|
|
Shared-based payment |
1,400,000
|
|
1,400,000
|
|
|
|
|
|
Balance at end of period (in shares) at Jun. 30, 2023 |
|
|
|
|
|
|
80,516,622
|
14,095
|
Balance at end of period at Jun. 30, 2023 |
57,863,000
|
4,027,000
|
381,371,000
|
(330,315,000)
|
1,064,000
|
1,718,000
|
|
|
Balance at beginning of period (in shares) at Dec. 31, 2023 |
|
|
|
|
|
|
80,860,563
|
14,090
|
Balance at beginning of period at Dec. 31, 2023 |
51,901,000
|
4,044,000
|
384,255,000
|
(329,323,000)
|
495,000
|
(7,570,000)
|
|
|
Net income (loss) |
(24,764,000)
|
|
|
|
|
(24,764,000)
|
|
|
Actuarial gains on defined benefit obligations |
116,000
|
|
|
|
116,000
|
|
|
|
Foreign currency translation loss |
(257,000)
|
|
|
|
(257,000)
|
|
|
|
Total comprehensive income (loss) |
(24,905,000)
|
|
|
|
(141,000)
|
(24,764,000)
|
|
|
Allocation of prior period income (loss) |
0
|
|
|
(7,570,000)
|
|
7,570,000
|
|
|
Exercise and subscription of equity instruments (in shares) |
|
|
|
|
|
|
106,844
|
|
Exercise and subscription of equity instruments |
93,000
|
5,342
|
88,003
|
|
|
|
|
|
Shared-based payment |
1,706,000
|
|
1,706,000
|
|
|
|
|
|
Balance at end of period (in shares) at Jun. 30, 2024 |
|
|
|
|
|
|
80,967,407
|
14,090
|
Balance at end of period at Jun. 30, 2024 |
€ 28,796,000
|
€ 4,049,075
|
€ 386,049,000
|
€ (336,893,000)
|
€ 354,000
|
€ (24,764,000)
|
|
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v3.24.2.u1
The Company and key events
|
6 Months Ended |
Jun. 30, 2024 |
Company Information [Abstract] |
|
The Company and key events |
The Company and key eventsThe company Innate Pharma SA (the “Company” and, with its subsidiary, referred to as the “Group”), is a global, clinical-stage biotechnology company developing immunotherapies for cancer patients. Its innovative approach aims to harness the innate immune system through therapeutic antibodies and its ANKET® (Antibody-based NK cell Engager Therapeutics) proprietary platform. Innate’s portfolio includes lead proprietary program lacutamab, developed in advanced form of cutaneous T cell lymphomas and peripheral T cell lymphomas, monalizumab developed with AstraZeneca in non-small cell lung cancer, as well as ANKET® multi-specific NK cell engagers to address multiple tumor types. Innate Pharma is a trusted partner to biopharmaceutical companies such as Sanofi and AstraZeneca, as well as leading research institutions, to accelerate innovation, research and development for the benefit of patients. Since its creation, the Company has suffered losses due to its research and development ("R&D") activities. The first half of 2024 generated a net loss of 24,764 thousand euros. As of June 30, 2024, shareholders' equity amounted to 28,796 thousand euros. Subject to receiving new milestone payments related to its collaboration agreements, the Company expects to incur additional losses until, if necessary, it can generate significant revenues from its drug candidates in development. The Company’s future operations are highly dependent on a combination of factors, including: (i) the success of its R&D; (ii) regulatory approval and market acceptance of the Company’s future drug candidates; (iii) the timely and successful completion of additional financing; and (iv) the development of competitive therapies by other biotechnology and pharmaceutical companies. As a result, the Company is and should continue, in the short to mid-term, to be financed through partnership agreements for the development and commercialization of its drug candidates and through the issuance of new equity instruments and debt financing. The activity of the Company is not subject to seasonal effects. As of June 30, 2024, the Company had one wholly owned subsidiary: Innate Pharma, Inc., incorporated under the laws of Delaware in 2009. The subsidiary is consolidated according global integration. Innate Pharma is based in Marseille, France and listed on Euronext Paris and Nasdaq in the United States., and had 168 full time equivalent employees as of June 30, 2024. Key events for the six-month period ended June 30, 2024•On March 6, 2024, the Company announced the treatment of the first patient in the Phase 1/2 trial evaluating IPH6501, a first-in-class CD20-targeting tetraspecific natural killer cell engager, from ANKET® platform, for the treatment of CD20-expressing B-cell Non-Hodgkin's Lymphomas. •On April 15, 2024, the Company announced the treatment of the first patient in the Phase 2 dose expansion part of the Sanofi-sponsored clinical trial evaluating NK Cell Engager SAR443579/ IPH6101 in various blood cancers. Under the terms of the 2016 agreement, this trial progress triggered a milestone payment of €4 million fully recognized in revenue during the first quarter of 2024. This amount was received by the Company on May 17, 2024. •On June 10, 2024, the Executive Board carried out a capital increase of €5,342 following the creation of 106,844 ordinary shares benefiting the employees of the company, including 68,744 ordinary shares issued free of charge (subscription). The capital increase carried out can be broken as follow : a creation of 68,744 free shares with a nominal value of €0.05 issued free of charge by deduction from the share premium, with a creation of 38,100 ordinary shares with a nominal value of €0.05 and an issue price of €2.45 (i.e an increase in share premium of €91,440).
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v3.24.2.u1
Basis of presentation and statement of compliance
|
6 Months Ended |
Jun. 30, 2024 |
Significant Accounting Policies [Abstract] |
|
Basis of presentation and statement of compliance |
Basis of presentation and statement of complianceBasis of preparation The interim condensed consolidated financial statements as of June 30, 2024 and for the six-months period ended June 30, 2024 and 2023 and the related notes (together, the “interim condensed consolidated financial statements”) have been prepared under the responsibility of the management of the Company in accordance with the underlying assumptions of going concern as the Company’s loss-making situation is explained by the innovative nature of the products developed, therefore involving a multi-year research and development phase. The interim condensed consolidated financial statements were closed by the Executive Board, approved and authorized by the Supervisory Board on September 11, 2024 upon recommendation of the Audit Committee on September 10, 2024. They have been prepared in accordance with IAS 34, ‘Interim Financial Reporting’ as issued by the International Accounting Standard Board (“IASB”). Due to the listing of ordinary shares of the Company on Euronext Paris and in accordance with the European Union’s regulation No. 1606/2002 of July 19, 2002, the interim condensed consolidated financial statements are also prepared in accordance with IFRS, as adopted by the European Union (EU).For the presented periods, the differences between IFRS as issued by IASB and IFRS adopted by EU had no impact on the interim condensed consolidated financial statements. The general accounting conventions were applied in accordance with the underlying assumptions, namely (i) going concern, (ii) permanence of accounting methods from one year to the next and (iii) independence of financial years, and in conformity with the general rules for the preparation and presentation of consolidated financial statements in accordance with International Financial Reporting Standards (“IFRS”). The interim condensed consolidated financial statements do not include all disclosures required for annual financial statements and should therefore be read in conjunction with the consolidated financial statements as of and for the year ended December 31, 2023. The results of the operations for the six months ended June 30, 2024 are not necessarily indicative of the results to be expected for the year ending December 31, 2024 or for any other interim period or for any year in the future. Except for number of shares and per share amounts, all amounts are expressed in thousands of euros, unless stated otherwise. Some amounts may be rounded for the calculation of financial information contained in the interim condensed consolidated financial statements. Accordingly, the totals in some tables may not be the exact sum of the preceding figures. Use of judgments and estimates The preparation of financial statements in accordance with IFRS requires the Company to make certain estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities at the date of the financial statements, and the reported amounts of revenue and expenses during the reporting period. These estimates can be revised where the circumstances on which they are based change. The actual results may therefore differ from the estimates initially formulated. The estimates and judgments which are mainly used by the Company are detailed in note 2.w) of the appendix to the consolidated financial statements as of December 31, 2023 filed with SEC (20-F) on April 2, 2024. As of June 30, 2024, the Company has not identified any other significant estimates and judgments that could have an impact on the consolidated financial statements. Recently issued accounting standards and interpretations Application of the following amended standards is mandatory for the first time for the financial period beginning on January 1, 2024 and, as such, they have been adopted by the Company: •Amendments to IAS 1 : Classification of liabilities with covenants; •Amendments to IAS 7 and IFRS 7 : Supplier finance arrangements; •Amendments to IFRS 16 : Lease liability in a sale and leaseback. Those amended standards have no impact on the interim condensed consolidated financial statements. The Company has not opted for the early application of any standards whose application would be mandatory from subsequent financial years. Translation of transactions denominated in foreign currency Foreign currency transactions are translated into the functionnal currency using the following exchange rates:
| | | | | | | | | | | | | | | | | | | | | | June 30, 2023 | December 31, 2023 | June 30, 2024 | €1 equals to | Average rate | Closing rate | Average rate | Closing rate | Average rate | Closing rate | USD | 1.0806 | 1.0866 | 1.0813 | 1.1050 | 1.0813 | 1.0705 |
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v3.24.2.u1
Cash, cash equivalents, short-term investments and non-current financial assets
|
6 Months Ended |
Jun. 30, 2024 |
Subclassifications of assets, liabilities and equities [abstract] |
|
Cash, cash equivalents, short-term investments and non-current financial assets |
Cash, cash equivalents, short-term investments and non-current financial assets | | | | | | | | | (in thousands of euro) | June 30, 2024 | December 31, 2023 | | | | Cash and cash equivalents | 69,990 | 70,605 | Short-term investments | 21,809 | 21,851 | Cash, cash equivalents and short-term investments | 91,799 | 92,456 | Non-current financial assets | 10,350 | 9,796 | Cash, cash equivalents and financial assets | 102,149 | 102,252 |
Cash and cash equivalents are mainly composed of current bank accounts, interest-bearing accounts and fixed-term accounts and mutual funds units (with short-term maturities) held with various banking institutions. As of June 30, 2024, the Company also holds shares in three mutual funds. The risk profiles of these funds are rated from 1 to 7 by the financial institution that manages and markets these funds (1 being the lowest risk profile).When the maturity of shares in mutual funds is longer than one year, they are classified as non-current financial instruments. Non-current financial assets generally include a guarantee of capital at the maturity date (which is always longer than one year). These instruments are defined by the Company as financial assets at fair value through profit or loss and classified as non-current due to their maturity. As of June 30, 2024 and December 31, 2023, the amount of cash, cash equivalents and financials assets denominated in US dollars amounted to €18,221 thousand and €20,798 thousand, respectively. Changes in short-term investments and non-current financial assets for the six months ended June 30, 2023 and 2024 are the following: | | | | | | | | | | | | | | | | | | | | | | | | (in thousands of euro) | December 31, 2023 | Additions (1) | Deductions (2) | Variance of fair value through the consolidated statement of income (loss) | Variation of accrued interests | Foreign currency effect | June 30, 2024 | Short-term investments | 21,851 | — | (1,215) | 438 | 212 | 524 | 21,810 | Non-current financial assets | 9,796 | — | — | 553 | — | — | 10,350 | Total | 31,647 | — | (1,215) | 991 | 212 | 524 | 32,160 |
| | | | | | | | | | | | | | | | | | | | | | | | (in thousands of euro) | December 31, 2022 | Additions | Deductions | Variance of fair value through the consolidated statement of income (loss) | Variation of accrued interests | Foreign currency effect | June 30, 2023 | Short-term investments | 17,260 | — | — | 271 | 232 | (288) | 17,475 | Non-current financial assets | 35,119 | — | — | 772 | (102) | — | 35,790 | Total | 52,379 | — | — | 1,043 | 130 | (288) | 53,265 |
(1) The additions correspond to both acquisitions and reclassifications of financial assets according to their maturity at the closing date. (2) The deductions correspond to both disposals and reclassifications of financial assets according to their maturity at the closing date. For the six months ended June 30, 2024 , variance of fair value through the consolidated statement of income (loss) is made of €553 thousand of unrealized gains on non-current financial assets and €438 thousand of unrealized gains on short-term investments. For the six months ended June 30, 2023, variance of fair value through the consolidated statement of income (loss) was made of €772 thousand of unrealized gains on non-current financial assets and €271 thousand of unrealized gains on short-term investments (see note 15).
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v3.24.2.u1
Trade receivables and others
|
6 Months Ended |
Jun. 30, 2024 |
Subclassifications of assets, liabilities and equities [abstract] |
|
Trade receivables and others |
Trade receivables and others | | | | | | | | | (in thousands of euro) | June 30, 2024 | December 31, 2023 | | | | Other receivables | 97 | 104 | | | | Research tax credit(1) | 12,755 | 29,755 | Other tax credits (2) | — | 361 | Prepaid expenses (3) | 3,009 | 5,692 | VAT refund | 583 | 1,037 | Trade account receivables (4) | 393 | 15,233 | Prepayments made to suppliers | 2,957 | 3,374 | | | | | | | Receivables and others | 19,795 | 55,557 | Research tax credit(1) | 13,850 | 9,800 | Prepaid expenses (3) | 628 | 754 | Receivables and others - non-current | 14,478 | 10,554 | Trade receivables and others | 34,273 | 66,111 |
(1) The Research tax credit (CIR) is recognized as other operating income in the year to which the eligible research expenditure relates. The amount of €29,755 thousand recognized as current receivables as of December 31, 2023 comprises the research tax credit for the 2019 and 2020 tax years, for which the three year period has expired as of December 31, 2023. The CIR for 2019 was reimbursed in January 2024 for an amount of €16,737 thousand and to the CIR for the 2020 tax year of €13,018 thousand was collected in July 2024 for the amount of €12,755 thousand following the offset of the restated amount of €263 thousand (see note 8). The amount of €13,850 thousand recognized as a non-current receivable as of June 30, 2024 corresponds to the CIR for the 2023 tax year for the amount of €9,800 thousand and the amount of CIR calculated for the first half of 2024 for the amount of €4,050 thousand. Following the loss of SME status since December 31, 2023, the CIR for 2023 and 2024 represent non-current receivables from the French Treasury, which should in principle be offset against corporate income tax due for the following three years or refunded if necessary upon expiry of such a period. (2) As of December 31, 2023, this amount mainly included a carry-back tax receivable of €333 thousand received in February 2024. (3) As of June 30,2024, the prepaid expenses includes include an amount of €879 thousand (1,005 thousand as of December 31, 2023) relating to the guarantee fees in line with the two State Guaranteed Loans from Société Générale and BNP Paribas. Following the extension of these two loans repayment for an additional period, the full amount of the guarantee fee over the additional five-year period has been recognized as an operating expense in 2022. For each period-end, an adjustment is made through the prepaid accounts to reflect the fact that the expenses are related to the fiscal year (see note 9). (4) As of December 31, 2023, the amount is mainly comprised of invoice of €15,000 thousand issued in December 2023 following the exercise of the license option by Sanofi. This amount was collected by the Company in January 2024. The net book value of the receivables is considered to be a reasonable approximation of their estimated fair value. No valuation allowance was recognized on trade receivables and others as the credit risk of each debtor was considered as not significant.
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v3.24.2.u1
Intangible assets
|
6 Months Ended |
Jun. 30, 2024 |
Intangible assets other than goodwill [abstract] |
|
Intangible assets |
Intangible assets | | | | | | | | | | | | | | | (in thousands of euro) | Purchased licenses | Other intangible assets | In progress | Total | | | | | | | | | | | January 1, 2023 | 1,556 | — | — | 1,556 | Acquisitions | — | — | — | — | Additional considerations(1) | 2,000 | — | — | 2,000 | Disposals | — | — | — | — | Amortizations(2) | (2,651) | — | — | (2,651) | Transfers | — | — | — | — | | | | | | June 30, 2023 | 903 | — | — | 903 | | | | | | | | | | | January 1, 2024 | 413 | 3 | — | 416 | Acquisitions | — | — | — | — | Additional considerations | — | — | — | — | Disposals | — | — | — | — | Amortizations(2) | (294) | (3) | — | (297) | Transfers | — | — | — | — | | | | | | June 30, 2024 | 119 | — | — | 119 | | | | | |
(1) This amount corresponds to the additional invoice received from Orega Biotech for the rights relating to IPH5201 following the first patient dosed in the Phase 2 MATISSE clinical trial in June 2023, in accordance to the agreement signed in 2019. This additional invoice is fully amortized as of June 30, 2023 and paid on July 2023. (2) As of June 30, 2024, this amount included the amortization of rights related to the monalizumab for an amount of €294 thousand. As of June 30, 2023, this amount includes the amortization of the additional payment made to Orega Biotech in 2023 for and amount of €2,000 thousand and the amortization of rights related to the monalizumab for an amount of €651 thousand.
Monalizumab rights under the 2014 monalizumab (NKG2A) Novo Nordisk agreement Since their acquisition, monalizumab rights are amortized on a straight-line basis over the anticipated residual duration of the Phase II trials. The Company has reassessed the anticipated residual duration of the Phase 2 trials as of June 30, 2024 and estimated that it would be fully amortized by 2024, which is the same estimation as of December 31, 2023, as a result of the completion of some trials and by modifying the estimated end dates relating to certain cohorts. The net book values of the monalizumab rights were €119 thousand and €416 thousand as of June 30, 2024 and December 31, 2023, respectively. IPH5201 (Anti-CD39) rights acquired from Orega Biotech On January 4, 2016, the Company and Orega Biotech entered into an exclusive licensing agreement by which Orega Biotech granted the Company full worldwide rights to its program of first-in-class anti-CD39 checkpoint inhibitors. The upfront payment paid by the Company to Orega Biotech has been recognized as an intangible asset in the consolidated financial statements for the year ended December 31, 2016. Criteria relating to the first development milestone were reached in December 2016. Consequently, the amount of this milestone was recognized as an intangible asset in addition to the initial payment. In June 2019, the Company also paid Orega Biotech €7.0 million in relation to the anti-CD39 program as consideration following the collaboration and option agreement signed on October 22, 2018 with AstraZeneca regarding IPH5201. Under this agreement, the Company also paid in April and June 2020, respectively €2.5 and €0.2 million to Orega Biotech following the first Phase 1 dosing relating to IPH5201. As a reminder, Orega Biotech claimed joint ownership of certain patents relating to IPH5201. The Company and Orega Biotech have resolved these claims in an arbitration proceeding, which decision was rendered in December 2021. As a result of this decision, the Company is required to pay a low-teen percentage of sub-licensing revenues received by the Company pursuant to its agreement with AstraZeneca regarding IPH5201. Following this arbitration decision, the Company paid in January 2022 an additional amount of €0.4 million to Orega. The Company announced on June 3, 2022 the progress of IPH5201 towards a study of Phase 2 in lung cancer, of which the Company will be a sponsor. In accordance with the amendment signed on June 1, 2022, the Company was eligible for a milestone payment of $5 million by AstraZeneca, received in August 2022 by the Company. In October 2022, the Company therefore paid an additional €0.6 million to Orega Biotech. On June 26, 2023, the Company announced the treatment of the first patient in the Phase 2 MATISSE trial, conducted in collaboration with AstraZeneca and evaluating IPH5201 in early-stage lung cancer. As a consequence, the Company made an additional payment of €2.0 million to Orega Biotech in July 2023, in accordance with the agreement signed in 2019. Avdoralimab (IPH5401) (anti-C5aR) rights acquired from Novo Nordisk A/S At the agreement inception, an upfront payment of €40 million for acquired rights were recorded as intangible asset. As part of this agreement, an additional amount of €1.0 million was paid in October 2020 to Novo Nordisk A / S following the launch of the first avdoralimab Phase II trial. As avdoralimab is still in clinical trial, the acquired rights are classified as intangible asset in progress. They were subject to annual impairment test. According to the agreement, the Company will pay additional payments according to the reach of specific steps. As of June 30, 2024, according to the uncertainty of these potential future payments, no liability was recognized. Development costs incurred by the Company are recognized as research and development expenses. As a reminder, during 2022 fourth quarter, the Company was informed by the sponsor of the Phase 2 clinical trial evaluating avdoralimab in inflammation in bullous pemphigoid ("BP") indication of its decision to discontinue said trial. Consequently, the Company decided in December 2022 to stop the development of avdoralimab in bullous pemphigoid ("BP") indication in inflammation, only indication supporting the recoverable amount of the asset as of December 31, 2021 (as well that as of June 30, 2022). Following that decision, the Company applied IAS 36 "Impairment of assets" and assessed that there was an indication of impairment sufficiently significant to result in the full impairment of the intangible asset. This depreciation was recognized with regard to the estimate of the recoverable value of avdoralimab's intangible assets, based on expected future cash flows, as of December 2022, date of the decision. Thus, on decision date to stop the development of avdoralimab in bullous pemphigoid ("BP") indication in inflammation, avdoralimab rights were fully written down to their net book value, i.e €41,000 thousand.
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v3.24.2.u1
Property and equipment
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6 Months Ended |
Jun. 30, 2024 |
Property, plant and equipment [abstract] |
|
Property and equipment |
Property and equipment | | | | | | | | | | | | | | | | | | (in thousands of euro) | Lands and buildings | Laboratory equipment and other | In progress | Total | Of which right of use assets | | | | | | | January 1, 2023 | 4,242 | 4,298 | — | 8,542 | 6,423 | Acquisitions | 31 | 279 | — | 310 | 79 | Disposals (1) | (513) | (78) | — | (591) | (513) | Depreciation | (323) | (670) | — | (993) | (428) | Transfers | — | — | — | — | — | | | | | | | June 30, 2023 | 3,437 | 3,829 | — | 7,268 | 5,561 | | | | | | | | | | | | | (in thousands of euro) | Lands and buildings | Laboratory equipment and other | In progress | Total | Of which right of use assets | | | | | | | January 1, 2024 | 2,958 | 3,378 | — | 6,322 | 5,055 | Acquisitions | 15 | 267 | 3 | 285 | 37 | Disposals | — | (18) | — | (18) | (18) | Depreciation | (352) | (493) | — | (845) | (392) | Transfers | — | — | — | — | — | | | | | | | June 30, 2024 | 2,621 | 3,134 | 3 | 5,748 | 4,682 |
(1) As a reminder, on March 13, 2023, the Company signed an amendment to the lease for the "Le Virage" building, reducing the surface area of the leased premises. The effective date of the lease amendment is March 15, 2023. As a result, and in accordance with IFRS 16, the impact on the consolidated balance sheet at the effective date of the lease amendment is as follows: write-off of a right of use (asset) of €0.5 million and a lease liability of €0.7 million.
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v3.24.2.u1
Trade payables and others
|
6 Months Ended |
Jun. 30, 2024 |
Subclassifications of assets, liabilities and equities [abstract] |
|
Trade payables and others |
Trade payables and others | | | | | | | | | (in thousands of euro) | June 30, 2024 | December 31, 2023 | | | | Suppliers (excluding payables related to capital expenditures) | 8,751 | 8,561 | Tax and employee-related payables (1) | 6,013 | 7,021 | Other payables (2) | 1,109 | 1,436 | Trade payables and others (excluding payables related to capital expenditures) | 15,873 | 17,018 | Payables related to capital expenditures | — | — | Payables and others | 15,873 | 17,018 |
(1) As of December 31, 2023, tax and employee related payables included a liability accrual of €1.4 million following the notification received as part of the tax inspection relating to accounting and research tax credits for the 2018 to 2020 financial years. The liability recognized as of June 30, 2024 in connection with notification is €0.4 million following the payment of €0.7 million in February 2024 and the offset of €0.3 million against the 2020 research tax credit receivable initially recognized for €13.0 million and finally collected in July 2024 for €12.7 million. (2) As of June 30, 2024 an December 31, 2023, this amount includes mainly the liability related to the payment of the guarantee fees on the two State Guaranteed Loans obtained from Société Générale and BNP Paribas in 2021 (see note 9). The book value of trade payables and others is considered to be a reasonable approximation of their fair value.
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v3.24.2.u1
Financial liabilities
|
6 Months Ended |
Jun. 30, 2024 |
Subclassifications of assets, liabilities and equities [abstract] |
|
Financial liabilities |
Financial liabilities | | | | | | | | | | | | | | | | | | | | | (in thousands of euro) | December 31, 2023 | Proceeds from borrowing | Proceeds from lease liabilities and other non cash effects | Repayments of borrowings/leases liabilities | Exchange rate variation (non cash) | June 30, 2024 | State guaranteed loan Société Générale (1) | 20,000 | — | — | (2,432) | — | 17,568 | State guaranteed loan BNP Paribas (1) | 8,700 | — | — | (1,070) | — | 7,630 | State guaranteed loans - accrued interest | 14 | — | 13 | (14) | — | 13 | | | | | | | | Lease liabilities – Building "Le Virage" (3) | 375 | — | — | (121) | — | 254 | Lease liabilities – Premises Innate Inc. | 246 | — | — | (47) | 8 | 207 | Lease liabilities – Laboratory equipment | 109 | — | — | (83) | — | 26 | Lease liabilities – Vehicles | 85 | — | 19 | (17) | — | 87 | Lease liabilities - Printers | 18 | — | — | (4) | — | 13 | Borrowing – Equipment | 99 | — | — | (28) | — | 71 | Borrowing – Building (2) | 10,247 | — | 17 | (630) | — | 9,634 | Total | 39,893 | — | 49 | (4,446) | 8 | 35,503 |
| | | | | | | | | | | | | | | | | | | | | (in thousands of euro) | December 31, 2022 | Proceeds from borrowing | Proceeds from lease liabilities and other non cash effects | Repayments of borrowings/leases liabilities | Exchange rate variation (non cash) | June 30, 2023 | State guaranteed loan Société Générale (1) | 20,000 | — | — | — | — | 20,000 | State guaranteed loan BNP Paribas (1) | 8,700 | — | — | — | — | 8,700 | State guaranteed loans - accrued interest | 15 | — | — | — | — | 15 | Lease liabilities – Building "Le Virage" | 1,353 | — | (736) | (130) | — | 487 | Lease liabilities – Premises Innate Inc. | 345 | — | — | (50) | 2 | 297 | Lease liabilities – Laboratory equipment | 287 | — | — | (89) | — | 198 | Lease liabilities – Vehicles | 33 | — | 48 | (13) | — | 70 | Lease liabilities - Printers | 27 | — | — | (4) | — | 23 | Borrowing – Equipment | 154 | — | — | (27) | — | 127 | Borrowing – Building (2) | 11,338 | — | — | (602) | — | 10,736 | Total | 42,251 | — | (689) | (916) | 2 | 40,658 |
(1) As a reminder, on January 5, 2022, the Company announced that it had obtained €28.7 million in non-dilutive financing in the form of two State Guaranteed Loans from Société Générale (€20.0 million) and BNP Paribas (€8.7 million). The Company received the funds related to these two loans on December 27 and 30, 2021 respectively. Both loans have an initial maturity of one year with an option to extend to five years usable from August, 2022. They are 90% guaranteed by the French government as part of the package of measures put in place by the French government to support companies during the COVID-19 pandemic. In August 2022, the Company has requested the extension of these two loans repayment for an additional period of five years starting in 2022 and including a one-year grace period. Consequently, the Company has obtained agreements from Société Générale and BNP Paribas. The effective interest rates applied to these contracts during the additional period are 1.56% and 0.95% for Société Générale and BNP Paribas loans, respectively, excluding insurance and guarantee fees, with an amortization exemption for the entire year 2023. During this grace period, the Company will only be liable for the payment of interest and the guarantee fees. The amortization of the two loans began in 2024 for a period of four years. The state guarantee fees amounts to €877 thousand and €379 thousand for Société Générale and BNP Paribas loans respectively. (2) On July 3, 2017, the Company borrowed from the Bank “Société Générale” in order to finance the construction of its future headquarters. This loan amounting to a maximum of €15,200 thousand will be raised during the period of the construction in order to pay the supplier payments as they become due. As of December 31, 2018 and 2019, the loan was raised at an amount of €1,300 thousand. The loan release period was limited to August 30, 2019. On August 30, 2019, the Company drew down the remaining portion of the €15,200 thousand loan granted, for an amount of €13,900 thousand. The reimbursement of the capital has begun in August 30, 2019 and will proceed until August 30, 2031 (12 years). Given the development of its portfolio and in particular the refocusing of its activities on research and development, the Company has for the time being suspended the project to build its new head office on the land acquired in Luminy. In the meantime, the loan will be used to finance several structuring projects (improvement of the information system, development of a commercial platform, development of additional premises rented, etc.). As of June 30, 2024, the remaining capital of the loan amounted to €9,617 thousand. The Company authorized collateral over financial “Société Générale” instruments amounting to €15,200 thousand. The security interest on the pledge financial instruments will be released in accordance with the following schedule: €4,200 thousand in July 2024, €5,000 thousand in August 2027 and €6,000 thousand in August 2031. Following the release of the pledge on the €4.2m financial instrument that had reached maturity, the company received this amount in July 2024. This loan bears a fixed interest rate of 2.01%. It is subject to a covenant based on the assumption that the total cash, cash equivalents and current and non-current financial assets are at least equal to principal as of financial year end. (3) As a reminder, on March 13, 2023, the Company signed an amendment to the lease for the "Le Virage" building, reducing the surface area of the leased premises. The effective date of the lease amendment is March 15, 2023. As a result, and in accordance with IFRS 16, the impact on the consolidated balance sheet at the effective date of the lease amendment is as follows: write-off of a right of use (asset) of €0.5 million and a lease liability of €0.7 million. The table below shows the schedule for the contractual repayment of financial liabilities (being principal and interest payments) as of June 30, 2024: | | | | | | | | | | | | | | | (in thousands of euro) | Within 1 year | From 2nd to 5th year included | Over 5 years | Total | | | | | | | | | | | | | | | | | | | | | State guaranteed loan Société Générale | 5,167 | 12,918 | — | 18,086 | State guaranteed loan BNP Paribas | 2,222 | 5,551 | — | 7,773 | State guaranteed loans - accrued interest | — | — | — | — | Lease liabilities – Building "Le Virage" | 254 | — | — | 254 | Lease liabilities – Premises Innate Inc. | 100 | 111 | — | 211 | Lease liabilities – Laboratory equipment | 26 | — | — | 26 | Lease liabilities – Vehicles | 34 | 59 | — | 92 | Lease liabilities - Printers | 9 | 4 | — | 13 | Borrowing – Equipment | 57 | 14 | — | 71 | Borrowing – Building | 1,545 | 5,587 | 3,210 | 10,342 | Total financial liabilities | 9,414 | 24,245 | 3,210 | 36,869 |
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v3.24.2.u1
Employee benefit
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6 Months Ended |
Jun. 30, 2024 |
Disclosure of information about defined benefit plans [abstract] |
|
Employee benefit |
Employee benefit Defined benefit obligation | | | | | | | | | (in thousands of euro) | June 30, 2024 | December 31, 2023 | | | | Allowance for retirement defined benefit | 2,118 | 2,064 | Allowance for seniority awards | 352 | 377 | Defined benefit obligations | 2,470 | 2,441 |
Amounts recognized in the statement of financial position are determined as follows (in thousand euros): | | | | | | As of January 1, 2023 | 2,550 | | | | | | | | | | | Service cost | 312 | Payments (benefits and contributions paid by the employer) | (27) | Actuarial (gain) / loss | (394) | | | As of December 31, 2023 | 2,441 | | | Service cost | 166 | Payments (benefits and contributions paid by the employer) | (22) | Actuarial (gain) / loss | (116) | | | As of June 30, 2024 | 2,470 |
Discount rates used by the Company to evaluate retirement benefits were based on iBoxx Corporate AA. It was 3.60% and 3.20% as of June 30, 2024 and December 31, 2023, respectively. In addition, the impact of the 2023 pension reform (including the raising of the retirement age) has been recognized as a plan amendment within the meaning of IAS 19, recognized in the income statement and balance sheet with no material impact at June 30, 2023.
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v3.24.2.u1
Capital
|
6 Months Ended |
Jun. 30, 2024 |
Share Capital and Share Base Payments [Abstract] |
|
Capital |
CapitalShare capital The Company manages its capital to ensure that the Company will be able to continue as a going concern while maximizing the return to shareholders through the optimization of the debt and equity balance. As of June 30, 2024, the Company’s share capital amounted to €4,049,075 divided into (i) 80,967,407 ordinary shares, each with a nominal value of €0.05; (ii) 6,509 “2016” preferred shares, each with a nominal value of €0.05, and (iii) 7,581 “2017” preferred shares, each with a nominal value of €0.05, respectively, fully paid up. Share capital does not include BSAs, BSAAR, AGAs and AGAPs that have been granted to certain investors or natural persons, both employees and non-employees of the Company, but not yet exercised. On October 21, 2019 and December 30, 2019, the retention period for the “2016 free preferred shares” has ended. The number of ordinary shares to which the conversion of one preferred share entitle has been determined according to the achievement of the performance criteria. Holders of “2016” preferred shares” are entitled to vote at our shareholders’ meetings, to dividends and to preferential subscription rights, on the basis of the number of ordinary shares to which they are entitled if they convert their preferred shares. In April 3, 2021, the retention period for the "2017 free preferred shares" has ended. The number of ordinary shares to which the conversion of one preferred share entitle has been determined according to the fulfillment of the performance criteria. According to these same performance criteria, the Executive Board of April 7, 2021 noted that the "2017 preferred shares" did not give right to any ordinary shares. The “2017 preferred shares” will not be redeemed by the Company and will remain incorporated into the capital, unless subsequently decided by the Executive Board. As the conversion is void, the "2017 preferred shares" no longer give the right to vote at our general meetings, nor to receive dividends. In the six months ended June 30, 2024, a capital increase of €5,342 occurred as a result of the Executive Board decision on June 10, 2024, subsequent to the creation of 106,844 ordinary shares following the set-up of a company saving plan for the benefit of the Company’s employees, including 68,744 ordinary shares issued free of charge (top-up). This event led to a net capital increase of €5,342 and an increase in share premium of €88,003, broken down as a creation of 38,100 ordinary shares, with a nominal value of €0.05, for an issue price of €2.45, (ii) a creation of 68,744 ordinary shares, with a nominal value of €0.05Treasury sharesThe Company held 18,575 of its own shares as of June 30, 2024 and December 31, 2023, respectively. Share based payments The Company has issued BSAs, BSAARs, AGAs and AGAPs as follows: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Date | | Types | | Number of warrants issued as of 6/30/2024 | | Number of warrants void as of 6/30/2024 | | Number of warrants exercised as of 6/30/2024 | | Number of warrants outstanding as of 6/30/2024 | | Maximum number of shares to be issued as of 6/30/2024 | | Exercise price per share (in €) | Sept. 9, 2011 | | BSAAR 2011 | | 650,000 | | 25,000 | | 625,000 | | — | | — | | 2.04 | May 27, 2013 | | BSAAR 2012 | | 146,050 | | 12,250 | | 133,800 | | — | | — | | 2.04 | July 1, 2015 | | BSAAR 2015 | | 1,050,382 | | 2,720 | | 1,940 | | 1,045,722 | | 1,045,722 | | 7.20 | October 21, 2016 | | AGAP Management 2016-1 | | 2,000 | | 550 | | 250 | | 1,200 | | 156,000 | | - |
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | October 21, 2016 | | AGAP Employees 2016-1 | | 2,486 | | 251 | | 172 | | 2,063 | | 268,190 | | - | October 21, 2016 | | AGA Management 2016-1 | | 50,000 | | — | | 50,000 | | — | | — | | - | December 30, 2016 | | AGAP Management 2016-2 | | 3,000 | | — | | — | | 3,000 | | 333,000 | | - | December 30, 2016 | | AGA Management 2016-2 | | 250,000 | | — | | 250,000 | | — | | — | | - | April 3,2018 | | AGAP Employees 2017-1 | | 5,725 | | 5,725 | | — | | — | | — | | - | April 3,2018 | | AGAP Management 2017-1 | | 2,400 | | 2,400 | | — | | — | | — | | — | April 3,2018 | | AGA Employees 2017 | | 114,500 | | 4,000 | | 110,500 | | — | | — | | — | July 3, 2018 | | AGA Bonus 2018-1 | | 67,028 | | 469 | | 66,559 | | — | | — | | - | November 20, 2018 | | AGAP Perf Employees 2018-1 | | 327,500 | | 224,375 | | 103,125 | | — | | — | | - | November 20, 2018 | | AGAP Perf Management 2018-1 | | 260,000 | | 150,000 | | 110,000 | | — | | — | | - | January 14, 2019 | | AGA Employees 2018 | | 90,650 | | 5,000 | | 85,650 | | — | | — | | - | April 29, 2019 | | AGA New Members 2017-1 | | 25,000 | | — | | 25,000 | | — | | — | | - | July 3, 2019 | | AGA Bonus 2019-1 | | 57,376 | | — | | 57,376 | | — | | — | | - | July 13, 2020 | | AGA Bonus 2020-1 & 2 | | 79,861 | | 17,885 | | 61,976 | | — | | — | | - | August 5, 2020 | | AGAP Employees 2020-1 | | 766,650 | | 681,420 | | 85,230 | | — | | — | | - | August 5, 2020 | | AGAP Management 2020-1 | | 710,000 | | 580,000 | | 130,000 | | — | | — | | - | July 22, 2021 | | AGA Bonus 2021-1 | | 125,748 | | — | | 125,748 | | — | | — | | - | October 1, 2021 | | AGAP Employees 2021-1 | | 1,066,600 | | 290,800 | | — | | 775,800 | | 775,800 | | - | October 1, 2021 | | AGAP Management 2021-1 | | 610,000 | | 130,000 | | — | | 480,000 | | 480,000 | | - | February 12, 2022 | | AGA "Plan Epargne Entreprise" 2022 | | 138,960 | | — | | 138,960 | | — | | — | | — | October 3, 2022 | | AGA Bonus 2022-1 | | 128,061 | | — | | 128,061 | | — | | — | | — | December 12, 2022 | | AGA Perf Employees 2022-1 | | 1,371,500 | | 275,000 | | — | | 1,096,500 | | 1,096,500 | | — | December 12, 2022 | | AGA Perf Management 2022-1 | | 550,000 | | — | | — | | 550,000 | | 550,000 | | — | April 14, 2023 | | AGA "Plan Epargne Entreprise" 2023 | | 163,293 | | — | | 163,293 | | — | | — | | — | November 2, 2023 | | AGA New members 2023-1 | | 25,000 | | — | | — | | 25,000 | | 25,000 | | — | December 21, 2023 | | AGA Perf Employees 2023-1 | | 1,403,500 | | 66,250 | | — | | 1,337,250 | | 1,337,250 | | — | December 21, 2023 | | AGA Perf Management 2023-1 | | 750,000 | | — | | — | | 750,000 | | 750,000 | | — | February 15, 2024 | | AGA New members 2024-1 | | 25,000 | | — | | — | | 25,000 | | 25,000 | | — | June 10, 2024 | | AGA "Plan Epargne Entreprise" 2024 | | 68,744 | | — | | 68,744 | | — | | — | | — | July 21, 2020 | | Stock Options 2020-1 | | 102,000 | | 102,000 | | — | | — | | — | | - | November 4, 2019 | | AGAP 2019 Employees 2019 | | 546,700 | | 375,150 | | 171,550 | | — | | — | | - | November 4, 2019 | | AGAP 2019 Management 2019 | | 355,000 | | 207,500 | | 147,500 | | — | | — | | - | July 29, 2011 | | BSA 2011-2 | | 225,000 | | 25,000 | | 200,000 | | — | | — | | 1.77 | July 17, 2013 | | BSA 2013 | | 237,500 | | 12,500 | | 225,000 | | — | | — | | 2.36 | July 16, 2014 | | BSA 2014 | | 150,000 | | — | | 75,000 | | 75,000 | | 75,000 | | 8.65 | April 27, 2015 | | BSA 2015-1 | | 70,000 | | — | | — | | 70,000 | | 70,000 | | 9.59 | July 1, 2015 | | BSA 2015-2 | | 14,200 | | — | | — | | 14,200 | | 14,200 | | 14.05 |
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | September 20, 2017 | | BSA 2017 | | 37,000 | | — | | — | | 37,000 | | 37,000 | | 11.00 | December 16, 2022 | | BSA 2022-1 | | 40,000 | | 31,740 | | — | | 8,260 | | 8,260 | | 2.31 | December 15, 2023 | | BSA 2023-1 | | 50,000 | | 12,000 | | — | | 38,000 | | 38,000 | | 2.26 | | | June 30, 2024 | | 12,914,414 | | 3,239,985 | | 3,340,434 | | 6,333,995 | | 7,084,922 | | |
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v3.24.2.u1
Financial instruments recognized in the statement of financial position and related effect on the income statement
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6 Months Ended |
Jun. 30, 2024 |
Disclosure of detailed information about financial instruments [abstract] |
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Financial instruments recognized in the statement of financial position and related effect on the income statement |
Financial instruments recognized in the statement of financial position and related effect on the income statement The following tables show the carrying amounts and fair values of financial assets and financial liabilities. The tables do not include fair value information for financial assets and financial liabilities not measured at fair value if the carrying amount is a reasonable approximation of fair value.
| | | | | | | | | | | | | | | As of June 30, 2024 | Book value on the statement of financial position | Fair value through profit and loss (1) | Amortized cost (2) | Fair value | Financial assets | | | | | Non-current financial assets | 10,350 | 10,350 | — | 10,350 | Trade receivables and others | 34,273 | — | 34,273 | 34,273 | Short-term investments | 21,809 | 21,809 | — | 21,809 | Cash and cash equivalents | 69,990 | 69,990 | — | 69,990 | Total financial assets | 136,422 | 102,149 | 34,273 | 136,422 | Financial liabilities | | | | | Financial liabilities—non-current portion | 26,574 | — | 26,574 | 26,574 | Financial liabilities—current portion | 8,929 | — | 8,929 | 8,929 | Trade payables and others | 15,873 | — | 15,873 | 15,873 | Total financial liabilities | 51,376 | — | 51,376 | 51,376 |
| | | | | | | | | | | | | | | As of December 31, 2023 | Book value on the statement of financial position | Fair value through profit and loss (1) | Amortized Cost (2) | Fair value | Financial assets | | | | | Non-current financial assets | 9,796 | 9,796 | — | 9,796 | Trade receivables and others | 66,111 | — | 66,111 | 66,111 | Short-term investments | 21,851 | 21,851 | — | 21,851 | Cash and cash equivalents | 70,605 | 70,605 | — | 70,605 | Total financial assets | 168,363 | 102,252 | 66,111 | 168,363 | Financial liabilities | | | | | Financial liabilities—non-current portion | 30,957 | — | 30,957 | 30,957 | Financial liabilities—current portion | 8,936 | — | 8,936 | 8,936 | Trade payables and others | 17,018 | — | 17,018 | 17,018 | Total financial liabilities | 56,911 | — | 56,911 | 56,911 |
(1) The fair value of financial assets classified as fair value through profit and loss corresponds to the market value of the assets, which are primarily determined using level 2 measurements.
(2) The book amount of financial assets and liabilities measured at amortized cost was deemed to be a reasonable estimation of fair value. In accordance with IFRS 7 and IFRS 13, financial instruments are presented in three categories based on a hierarchy of methods used to determine fair value:
Level 1: fair value determined based on quoted prices in active markets for assets or liabilities;
Level 2: fair value determined on the observable database for the asset or liability concerned either directly or indirectly;
Level 3: fair value determined on the basis of evaluation techniques based in whole or in part on unobservable data.
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v3.24.2.u1
Revenue and other income
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6 Months Ended |
Jun. 30, 2024 |
Disclosure of disaggregation of revenue from contracts with customers [abstract] |
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Revenue and other income |
Revenue and other incomeRevenue from collaboration and licensing agreements Revenues from collaboration and licensing agreements result from agreements signed with AstraZeneca, Sanofi and Takeda :
| | | | | | | | | (in thousands of euro) | June 30, 2024 | June 30, 2023 | | | | Proceeds from collaboration and licensing agreements | 7,396 | 34,728 | of which monalizumab agreement (AstraZeneca) | 2,994 | 9,503 | | | | | | | of which 2016 Sanofi agreement | 4,000 | 2,000 | of which Sanofi agreement 2022 - ANKET IPH62 - Recognition of license initial payment and income related to the completion of work in line with the joint research program | 199 | 18,672 | of which Sanofi agreement 2022 - ANKET IPH67 -Recognition of license initial payment, income related to the option exercise and income related to the completion of work in line with the joint research program | 203 | — | of which Takeda agreement | — | 4,553 | | | | Invoicing of R&D costs (IPH5201 agreement) | 897 | 616 | | | | Revenue from collaboration and licensing agreements | 8,293 | 35,344 |
a) Revenue recognition related to monalizumab AZ agreements and amendments Change in deferred revenue relating to monalizumab agreement: | | | | | | (in thousands of euro) | Total | As of December 31, 2022 | 14,481 | | | Revenue for the six months ended June 30, 2023 | (9,503) | Transfer from / (to) collaboration liabilities | (283) | As of June 30, 2023 | 4,695 | | | As of December 31, 2023 | 5,156 | | | Revenue for the six months ended June 30, 2024 | (2,994) | Transfer from / (to) collaboration liabilities | (172) | As of June 30, 2024 | 1,990 |
Change in collaboration liabilities relating to monalizumab agreement: | | | | | | (in thousands of euro) | Total | As of December 31, 2022 | 63,211 | Additions | 283 | Deductions | (7,436) | As of June 30, 2023 | 56,058 | | | As of December 31, 2023 | 52,677 | Additions | 1,891 | Deductions | (2,419) | As of June 30, 2024 | 52,149 |
b) Revenue recognition related to IPH5201 AstraZeneca collaboration and option agreement Revenue related to IPH5201 for the six months ended June 30, 2024 and June 30, 2023 are nil. As a reminder, the Company signed on June 1, 2022 an amendment to the initial contract signed in October 2018. This amendment set the terms of the collaboration following AstraZeneca’s decision to advance IPH5201 to a Phase 2 study. The Company will conduct the study. Both parties will share the external cost related to the study and incurred by the Company and AstraZeneca will provide products necessary to conduct the clinical trial. Under the terms of this agreement, an amount of €897 thousand was rebilled to AstraZeneca during the first half of 2024 (€616 thousand during the first half of 2023). c) Revenue related to IPH6401 - Sanofi (2016)
Revenue related to IPH6401 under the collaboration and license agreement signed with Sanofi is €4,000 thousand for the six months ended June 30, 2024, as compared to a revenue of €2,000 thousand as of June 30, 2023. During the period, the Company announced that the first patient was dosed in the Phase 2 dose expansion part of the Sanofi-sponsored clinical trial of SAR443579 / IPH6101, evaluating SAR443579 as a monotherapy for the treatment of blood cancers with high unmet needs. Under the terms of the 2016 research and licensing agreement with Sanofi, dosing of the first patient in the dose expansion part of the trial triggered a milestone payment to the Company of €4 million recognized as revenue as of June 30, 2024. This amount was received by the Company on May 17, 2024. As a reminder, the Company announced that, in June 2023, the first patient was dosed in a Sanofi-sponsored Phase 1/2 clinical trial evaluating IPH6401/SAR'514 in relapsed or refractory Multiple Myeloma. Under the terms of the licensing agreement signed in 2016, Sanofi made a milestone payment of €2,000 thousand, fully recognized in revenue as of June 30, 2023. This amount was received by the Company on July 21, 2023. d) Revenue related to Sanofi research collaboration and licensing agreement (2022) On January 25, 2023, the Company announced the expiration of the waiting period under the Hart-Scott-Rodino (HSR) Antitrust Improvements Act of 1976 and the effectiveness of the licensing agreement as of January 24, 2023. Consequently, under the terms of such agreement, the Company received an upfront payment of €25,000 thousand in March 2023, including €18,500 thousand for the exclusive license, €1,500 thousand for the research work and €5,000 thousand for the two additional targets options. On December 19, 2023, the Company announced that Sanofi had exercised an option for one of the two targets. This option exercise also resulted in a milestone payment of €15,000 thousand, including €13,300 thousand in respect of the exclusive license, which was fully recognized in income as of December 31, 2023, and €1,700 thousand for the research activities to be carried out by the Company. The Company considers that the license to the B7-H3 technology is a right to use the intellectual property granted exclusively to Sanofi from the effective date of the agreement. As such, all upfront payments relating to the licenses granted have been recognized in the income statement representing an amount of €31,800 thousand, including €18.5 million relating to B7-H3 license and €13,300 thousand following the option exercised.
Change in deferred revenue relating to the 2022 research collaboration and licensing agreement : | | | | | | (in thousands of euro) | Total | As of December 31, 2022 | — | Additions (1) | 6,500 | Deductions | (172) | As of June 30, 2023 | 6,328 | | | | | | | | |
| | | | | | (in thousands of euro) | Total | As of December 31, 2023 | 5,327 | Additions | — | Deductions | (402) | As of June 30, 2024 | 4,925 | | | | | | | | |
(1) The increase in deferred revenue relating to the 2022 research collaboration and licensing agreement with Sanofi between December 31, 2022 and June 30, 2023 mainly comprises (i) an upfront payment of €5,000 thousand relating to the granting of two options for exclusive licenses on Innate's intellectual property for the research, development, manufacturing and commercialization of NKCEs specifically targeting two preclinical molecules. The Company will recognize the related revenues either at the reporting date or three years after the effective date; as well as (ii) an amount of €1,500 thousand relating to research activities to perform in collaboration with Sanofi. The Company will recognize the related revenues on a straight-line basis over the duration of the research work to which the Company has agreed. e) Schedule of variance of deferred revenue
| | | | | | | | | | | | | | | | | | (in thousands of euro) | As of December 31, 2023 | Recognition in P&L | Proceeds | Transfer from / (to) collaboration liabilities | As of June 30, 2024 | Monalizumab | 5,155 | (2,994) | — | (172) | 1,990 | | | | | | | Sanofi (2022) option | 2,500 | — | — | — | 2,500 | Sanofi (2022) services | 2,826 | (402) | — | — | 2,424 | | | | | | | Total | 10,481 | (3,396) | — | (172) | 6,915 |
| | | | | | | | | | | | | | | | | | (in thousands of euro) | As of December 31, 2022 | Recognition in P&L | Proceeds | Transfer from / (to) collaboration liabilities | As of June 30, 2023 | Monalizumab | 14,481 | (9,503) | — | (283) | 4,696 | | | | | | | Sanofi (2022) option | — | — | 5,000 | — | 5,000 | Sanofi (2022) services | — | (172) | 1,500 | — | 1,328 | Total | 14,481 | (9,675) | 5,000 | (283) | 11,024 |
Government financing for research expendituresThe Company receives grants from the European Commission, French government and state organizations in several different forms: •Research Tax Credits; and • Investment and operating grants. As of June 30, 2024 and 2023, an estimate of the research tax credit amount for the first half period is calculated on the basis of eligible expenses over the period. The total amount for government financing for research expenditures recorded as other income in the income statement can be analysed as follows: | | | | | | | | | (in thousands of euro) | June 30, 2024 | June 30, 2023 | | | | Research tax credit | 4,050 | 4,854 | Grant | 2 | — | Government financing for research expenditures | 4,052 | 4,854 |
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v3.24.2.u1
Operating expenses
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6 Months Ended |
Jun. 30, 2024 |
Analysis of income and expense [abstract] |
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Operating expenses |
Operating expenses | | | | | | | | | | | | | | | | | | | | | (in thousands of euro) | June 30, 2024 | June 30, 2023 | | R&D | G&A | Total | R&D | G&A | Total | Subcontracting costs(1) | (15,585) | — | (15,585) | (15,857) | — | (15,857) | Cost of supplies and consumable materials | (1,485) | (153) | (1,638) | (1,410) | (100) | (1,510) | Personnel expenses other than share-based compensation | (7,532) | (3,470) | (11,002) | (7,781) | (3,871) | (11,652) | Share-based compensation | (1,175) | (531) | (1,706) | (905) | (496) | (1,401) | Personnel expenses | (8,707) | (4,001) | (12,708) | (8,686) | (4,367) | (13,053) | Non-scientific advisory and consulting(2) | (124) | (1,934) | (2,058) | (532) | (1,662) | (2,194) | Leasing and maintenance | (490) | (710) | (1,200) | (470) | (445) | (915) | Travel expenses and meeting attendance | (272) | (151) | (423) | (180) | (143) | (323) | Marketing, communication and public relations | (16) | (164) | (180) | (34) | (142) | (176) | Scientific advisory and consulting(3) | (933) | — | (933) | (561) | — | (561) | Other purchases and external expenses | (10) | (1,125) | (1,135) | (13) | (1,153) | (1,166) | Depreciation and amortization | (643) | (503) | (1,146) | (3,044) | (601) | (3,645) | Intellectual property expenses | (568) | (128) | (696) | (570) | (68) | (638) | Other income and (expenses), net | (242) | (714) | (956) | (98) | (464) | (562) | | | | | | | | Total operating expenses | (29,076) | (9,582) | (38,657) | (31,453) | (9,144) | (40,597) |
(1)The Company subcontracts a significant part of its pre-clinical (pharmaceutical development, tolerance studies and other model experiments, etc.) and clinical operations (coordination of trials, hospital costs, etc.) to third parties. (2)Non-scientific advisory and consulting are services performed to support the general and administration activities of the Company, such as legal, accounting and audit fees as well as business development support. (3)Scientific advisory and consulting expenses relate to consulting services performed by third parties to support the research and development activities of the Company. Personnel expenses other than share-based compensationThe line item amounted to €11,002 thousand and €11,652 thousand for the six months ended June 30, 2024 and 2023 respectively. The Company had 168 full time equivalent employees as of June 30, 2024, compared to 191 as of June 30, 2023. June 30, 2024, we had 135 employees, in research and development functions, compared to 151 employees as of June 30, 2023. Meanwhile, the administrative staff, totaled 39 people, compared to 45. Depreciation and amortization As of June 30, 2023, this amount includes the amortization of the additional payment made to Orega Biotech in 2023 for and amount of €2,000 thousand and the amortization of rights related to the monalizumab for an amount of €651 thousand. As of June 30, 2024, this amount included the amortization of rights related to the monalizumab for an amount of €294 thousand . (see Note 6). Cost of suppliers and consumable materialsCost of supplies and consumable materials consists mainly of the cost of procurement of the Company’s drug substance and/or drug product that is manufactured by third-parties, respectively.
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v3.24.2.u1
Net financial income / (loss)
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6 Months Ended |
Jun. 30, 2024 |
Analysis of income and expense [abstract] |
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Net financial income / (loss) |
Net financial income / (loss) Net financial income (loss) can be analyzed as follows : | | | | | | | | | (in thousands of euro) | June 30, 2024 | June 30, 2023 | | | | Interests on financial assets | 1,269 | 965 | Change in valuation allowance on financial instruments | 1,471 | 1,044 | Foreign exchange gains | 873 | 1,073 | | | | Financial income | 3,613 | 3,083 | Foreign exchange losses | (1,763) | (642) | Unrealized losses on financial assets | — | — | Interest on financial liabilities | (300) | (324) | | | | Financial expenses | (2,064) | (966) | Net financial income (loss) | 1,549 | 2,116 |
For the six months ended June 30, 2024 and 2023, the foreign exchange gains and losses mainly result from the variance of the exchange rate between the Euro and the US dollar on US dollars denominated cash and cash equivalent and financial assets accounts. Unrealized losses on financial assets relate to unquoted instruments, the fair value of which is determined using level 2 measurements.
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v3.24.2.u1
Income tax / (expense)
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6 Months Ended |
Jun. 30, 2024 |
Income taxes paid (refund) [abstract] |
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Income tax / (expense) |
Income tax / (expense) Due to the Company’s early stage of development, it is not probable that future taxable profit will be available against which the unused tax losses can be utilized. As a consequence, deferred tax assets are recognized up to deferred tax liabilities. The main temporary differences are related to the application of the IFRS 15 standard for fiscal years beginning on or after January 1, 2018, finance leases, provisions for pension commitments and tax loss carryforwards. The Company did not recognize a current tax expense as of June 30, 2024 regarding a projected tax rate of nil as of December 31, 2024. As of June 30, 2024, the accumulated tax losses carryforwards of Innate Pharma SA were €483,570 thousand with no expiration date (same amount as of December 31, 2023). As of June 30, 2024, the accumulated tax losses carryforwards of Innate Pharma Inc was €15,181 thousand or $16,775 thousand (same amount as of December 31, 2023).
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v3.24.2.u1
Commitments, contingencies and litigation
|
6 Months Ended |
Jun. 30, 2024 |
Commitments, Contingencies And Litigations [Abstract] |
|
Commitments, contingencies and litigation |
Commitments, contingencies and litigationCommitments The Company has identified the following changes in off-balance sheet commitments since December 31, 2023: •non-cancellable purchase commitments as of June 30, 2024 for a total of €6,612 thousand with various CMOs. These commitments are comprised of non-cancellable purchase orders placed during the first half of 2024 with contract manufacturing organizations (CMOs) for the supply of various services in relation with preclinical work for an amount of €3,020 thousand and clinical work for an amount of €3,592 thousand. The execution and billing of these services has not yet started at the date of this report. •financial commitments with Société Générale in connection with the Company’s subscription of a loan in order to finance the construction of its future headquarters. As security for the loan, the Company pledged collateral in the form of financial instruments held at Société Générale amounting to €15.2 million. The security interest on the pledged financial instruments will be released in accordance with the following schedule: €4,200 thousand in July 2024, €5,000 thousand in August 2027 and €6,000 thousand in August 2031. At the date of this report, the first investment of €4,200 thousand had matured and the Company obtained its restitution in July 2024 for a total amount of €4,427 thousand, including interest. As of June 30, 2024, the remaining capital of this loan amounted to €9,617 thousand. Furthermore, under the loan, Innate is subject to a covenant that its total cash, cash equivalents and current and non-current financial assets as of each fiscal year end will be at least equal to the amount of outstanding principal under the loan. The Company was in compliance with this covenant as of December 31, 2023. Contingencies and litigationsThe Company is exposed to contingent liabilities happening in the ordinary course of its activities. Each pre-litigation, known litigation or procedure in course the Company is involved in is analyzed at each closing date after consultation of legal counsel. There is no acknowledged litigation as of June 30, 2024. ProvisionsProvisions amounted to €669 thousand and €774 thousand as of June 30, 2024 and December 31, 2023, respectively. As of June 30, 2024, they mainly consist of provision for charges amounting €586 thousand relating to the employer contribution in respect of the grants of employee equity instruments. In accordance with French social legislation, when a Company decides to provide its employees with shares bought back on the market, a provision has to be recognized upon the decision to allocate free shares that are spread over the vesting period when the plan conditions actions for employees when they join the Company at the end of the plan. As a reminder, on March 16, 2022, the Company received a notice of a tax inspection by the French tax authorities and relating to the 2019 and 2020 financial years as well as to the research tax credit and the accuracy of its calculation for the 2018 to 2018 financial years 2020. On February 13, 2024, the Company was informed of the tax authorities conclusions regarding the tax inspection. A definitive amount of €1,367 thousand was determined and classified as short-term tax liabilities as of December 31, 2023. During the first half of 2024, the Company made a payment of €693 thousand.
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v3.24.2.u1
Related party transactions
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6 Months Ended |
Jun. 30, 2024 |
Related party transactions [abstract] |
|
Related party transactions |
Related party transactions Members of the Executive Board and Other Executive Members For each of the period presented, the following compensation was granted to the members of the Executive Committee of the Company and were recognized as expense:
| | | | | | | | | (in thousands of euro) | June 30, 2024 | June 30, 2023 | | | | Personnel and other short-term employee benefits | 1,713 | 1,386 | Extra pension benefits | 21 | 11 | Share-based compensation | 519 | 408 | Advisory fees | — | 318 | Executive Board Members and other Executive Members compensation | 2,253 | 2,123 |
Personnel and other short-term employee benefits correspond to amounts included in personnel expenses for the six-month periods ended June 30, 2024 and 2023 respectively. As of June 30, 2024, the Company has also recognized expenses totaling €184 thousand with companies in which a mandate is held by the identified related parties. Members of the Supervisory Board The Company recognized a provision of €163 thousand for attendance fees (jetons de presence) relating to the six months ended June 30, 2024. This amount includes the compensation for the Chairman of the Supervisory Board. Related parties Novo Nordisk A/S is a shareholder, Supervisory Board member and is related to the Company by three licensing agreements related to the drug candidates lirilumab, monalizumab and avdoralimab. Under the terms of the agreements, Novo Nordisk A/S is eligible to receive milestone payments as well as royalties on future sales. As of June 30, 2024, the Company has no liability to Novo Nordisk A/S. AstraZeneca is a shareholder and is related to the Company through several collaboration and option licensing or license agreements for different drug candidates (monalizumab, avdoralimab and IPH5201). The payments between the two companies as well as the liabilities and receivables as of June 30, 2024 are as follows: | | | | | | | | | | As of June 30,2024 | (in thousands of euro) | Payments | Assets/Liabilities | | | | Collection (AstraZeneca to the Company) / Receivables | 1,657 | 394 | Payments (the Company to AstraZeneca) / Liabilities | (3,342) | (3,926) | Total | (1,685) | (3,532) |
Subsidiaries The business relationships between the Company and its subsidiary are governed by intra-group and commercial agreements, concluded at market standard conditions on an arm’s length basis.
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v3.24.2.u1
Income / (loss) per share
|
6 Months Ended |
Jun. 30, 2024 |
Income (Loss) Per Share [Abstract] |
|
Income / (loss) per share |
Income / (loss) per share Basic income / (loss) per share Basic income / (loss) per share are calculated by dividing the net earnings attributable to equity holders of the Company by the weighted average number of ordinary shares in issue during the period.
| | | | | | | | | | June 30, 2024 | June 30, 2023 | | | | Net income/(loss) | (24,764) | 1,718 | Weighted average number of ordinary shares in circulation | 80,872,369 | 80,319,897 | Basic income/(loss) per share (€ per share) | (0.31) | 0.02 |
Diluted income / (loss) per shareDiluted income (loss) per share is calculated by dividing the net income (loss) attributable to equity holders of the Company by the weighted average number of ordinary shares in circulation during the corresponding period, increased by all dilutive potential common shares.
| | | | | | | | | In thousands of euro, except for data share | June 30, 2024 | June 30, 2023 | Net income/(loss) for the period | (24,764) | 1,718 | Weighted average number of ordinary shares in circulation | 80,872,369 | 80,319,897 | Adjustment for share instruments | 5,026,389 | 3,461,439 | Diluted income/(loss) per share (€ per share) | (0.31) | 0.02 |
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v3.24.2.u1
Basis of presentation and statement of compliance (Policies)
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6 Months Ended |
Jun. 30, 2024 |
Significant Accounting Policies [Abstract] |
|
Basis of preparation |
Basis of preparation The interim condensed consolidated financial statements as of June 30, 2024 and for the six-months period ended June 30, 2024 and 2023 and the related notes (together, the “interim condensed consolidated financial statements”) have been prepared under the responsibility of the management of the Company in accordance with the underlying assumptions of going concern as the Company’s loss-making situation is explained by the innovative nature of the products developed, therefore involving a multi-year research and development phase. The interim condensed consolidated financial statements were closed by the Executive Board, approved and authorized by the Supervisory Board on September 11, 2024 upon recommendation of the Audit Committee on September 10, 2024. They have been prepared in accordance with IAS 34, ‘Interim Financial Reporting’ as issued by the International Accounting Standard Board (“IASB”). Due to the listing of ordinary shares of the Company on Euronext Paris and in accordance with the European Union’s regulation No. 1606/2002 of July 19, 2002, the interim condensed consolidated financial statements are also prepared in accordance with IFRS, as adopted by the European Union (EU).For the presented periods, the differences between IFRS as issued by IASB and IFRS adopted by EU had no impact on the interim condensed consolidated financial statements. The general accounting conventions were applied in accordance with the underlying assumptions, namely (i) going concern, (ii) permanence of accounting methods from one year to the next and (iii) independence of financial years, and in conformity with the general rules for the preparation and presentation of consolidated financial statements in accordance with International Financial Reporting Standards (“IFRS”). The interim condensed consolidated financial statements do not include all disclosures required for annual financial statements and should therefore be read in conjunction with the consolidated financial statements as of and for the year ended December 31, 2023. The results of the operations for the six months ended June 30, 2024 are not necessarily indicative of the results to be expected for the year ending December 31, 2024 or for any other interim period or for any year in the future. Except for number of shares and per share amounts, all amounts are expressed in thousands of euros, unless stated otherwise. Some amounts may be rounded for the calculation of financial information contained in the interim condensed consolidated financial statements. Accordingly, the totals in some tables may not be the exact sum of the preceding figures.
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Use of judgments and estimates |
Use of judgments and estimates The preparation of financial statements in accordance with IFRS requires the Company to make certain estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities at the date of the financial statements, and the reported amounts of revenue and expenses during the reporting period. These estimates can be revised where the circumstances on which they are based change. The actual results may therefore differ from the estimates initially formulated. The estimates and judgments which are mainly used by the Company are detailed in note 2.w) of the appendix to the consolidated financial statements as of December 31, 2023 filed with SEC (20-F) on April 2, 2024. As of June 30, 2024, the Company has not identified any other significant estimates and judgments that could have an impact on the consolidated financial statements.
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Recently issued accounting standards and interpretations |
Recently issued accounting standards and interpretations Application of the following amended standards is mandatory for the first time for the financial period beginning on January 1, 2024 and, as such, they have been adopted by the Company: •Amendments to IAS 1 : Classification of liabilities with covenants; •Amendments to IAS 7 and IFRS 7 : Supplier finance arrangements; •Amendments to IFRS 16 : Lease liability in a sale and leaseback. Those amended standards have no impact on the interim condensed consolidated financial statements. The Company has not opted for the early application of any standards whose application would be mandatory from subsequent financial years.
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Translation of transactions denominated in foreign currency |
Translation of transactions denominated in foreign currency Foreign currency transactions are translated into the functionnal currency using the following exchange rates:
| | | | | | | | | | | | | | | | | | | | | | June 30, 2023 | December 31, 2023 | June 30, 2024 | €1 equals to | Average rate | Closing rate | Average rate | Closing rate | Average rate | Closing rate | USD | 1.0806 | 1.0866 | 1.0813 | 1.1050 | 1.0813 | 1.0705 |
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v3.24.2.u1
Cash, cash equivalents, short-term investments and non-current financial assets (Tables)
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6 Months Ended |
Jun. 30, 2024 |
Subclassifications of assets, liabilities and equities [abstract] |
|
Disclosure of cash, cash equivalents and financial assets |
| | | | | | | | | (in thousands of euro) | June 30, 2024 | December 31, 2023 | | | | Cash and cash equivalents | 69,990 | 70,605 | Short-term investments | 21,809 | 21,851 | Cash, cash equivalents and short-term investments | 91,799 | 92,456 | Non-current financial assets | 10,350 | 9,796 | Cash, cash equivalents and financial assets | 102,149 | 102,252 |
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Disclosure of reconciliation of changes in short-term investments and non-current financial assets |
Changes in short-term investments and non-current financial assets for the six months ended June 30, 2023 and 2024 are the following: | | | | | | | | | | | | | | | | | | | | | | | | (in thousands of euro) | December 31, 2023 | Additions (1) | Deductions (2) | Variance of fair value through the consolidated statement of income (loss) | Variation of accrued interests | Foreign currency effect | June 30, 2024 | Short-term investments | 21,851 | — | (1,215) | 438 | 212 | 524 | 21,810 | Non-current financial assets | 9,796 | — | — | 553 | — | — | 10,350 | Total | 31,647 | — | (1,215) | 991 | 212 | 524 | 32,160 |
| | | | | | | | | | | | | | | | | | | | | | | | (in thousands of euro) | December 31, 2022 | Additions | Deductions | Variance of fair value through the consolidated statement of income (loss) | Variation of accrued interests | Foreign currency effect | June 30, 2023 | Short-term investments | 17,260 | — | — | 271 | 232 | (288) | 17,475 | Non-current financial assets | 35,119 | — | — | 772 | (102) | — | 35,790 | Total | 52,379 | — | — | 1,043 | 130 | (288) | 53,265 |
(1) The additions correspond to both acquisitions and reclassifications of financial assets according to their maturity at the closing date. (2) The deductions correspond to both disposals and reclassifications of financial assets according to their maturity at the closing date.
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v3.24.2.u1
Trade receivables and others (Tables)
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6 Months Ended |
Jun. 30, 2024 |
Subclassifications of assets, liabilities and equities [abstract] |
|
Disclosure of trade receivables and others |
| | | | | | | | | (in thousands of euro) | June 30, 2024 | December 31, 2023 | | | | Other receivables | 97 | 104 | | | | Research tax credit(1) | 12,755 | 29,755 | Other tax credits (2) | — | 361 | Prepaid expenses (3) | 3,009 | 5,692 | VAT refund | 583 | 1,037 | Trade account receivables (4) | 393 | 15,233 | Prepayments made to suppliers | 2,957 | 3,374 | | | | | | | Receivables and others | 19,795 | 55,557 | Research tax credit(1) | 13,850 | 9,800 | Prepaid expenses (3) | 628 | 754 | Receivables and others - non-current | 14,478 | 10,554 | Trade receivables and others | 34,273 | 66,111 |
(1) The Research tax credit (CIR) is recognized as other operating income in the year to which the eligible research expenditure relates. The amount of €29,755 thousand recognized as current receivables as of December 31, 2023 comprises the research tax credit for the 2019 and 2020 tax years, for which the three year period has expired as of December 31, 2023. The CIR for 2019 was reimbursed in January 2024 for an amount of €16,737 thousand and to the CIR for the 2020 tax year of €13,018 thousand was collected in July 2024 for the amount of €12,755 thousand following the offset of the restated amount of €263 thousand (see note 8). The amount of €13,850 thousand recognized as a non-current receivable as of June 30, 2024 corresponds to the CIR for the 2023 tax year for the amount of €9,800 thousand and the amount of CIR calculated for the first half of 2024 for the amount of €4,050 thousand. Following the loss of SME status since December 31, 2023, the CIR for 2023 and 2024 represent non-current receivables from the French Treasury, which should in principle be offset against corporate income tax due for the following three years or refunded if necessary upon expiry of such a period. (2) As of December 31, 2023, this amount mainly included a carry-back tax receivable of €333 thousand received in February 2024. (3) As of June 30,2024, the prepaid expenses includes include an amount of €879 thousand (1,005 thousand as of December 31, 2023) relating to the guarantee fees in line with the two State Guaranteed Loans from Société Générale and BNP Paribas. Following the extension of these two loans repayment for an additional period, the full amount of the guarantee fee over the additional five-year period has been recognized as an operating expense in 2022. For each period-end, an adjustment is made through the prepaid accounts to reflect the fact that the expenses are related to the fiscal year (see note 9). (4) As of December 31, 2023, the amount is mainly comprised of invoice of €15,000 thousand issued in December 2023 following the exercise of the license option by Sanofi. This amount was collected by the Company in January 2024.
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v3.24.2.u1
Intangible assets (Tables)
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6 Months Ended |
Jun. 30, 2024 |
Intangible assets other than goodwill [abstract] |
|
Disclosure of detailed information about intangible assets |
| | | | | | | | | | | | | | | (in thousands of euro) | Purchased licenses | Other intangible assets | In progress | Total | | | | | | | | | | | January 1, 2023 | 1,556 | — | — | 1,556 | Acquisitions | — | — | — | — | Additional considerations(1) | 2,000 | — | — | 2,000 | Disposals | — | — | — | — | Amortizations(2) | (2,651) | — | — | (2,651) | Transfers | — | — | — | — | | | | | | June 30, 2023 | 903 | — | — | 903 | | | | | | | | | | | January 1, 2024 | 413 | 3 | — | 416 | Acquisitions | — | — | — | — | Additional considerations | — | — | — | — | Disposals | — | — | — | — | Amortizations(2) | (294) | (3) | — | (297) | Transfers | — | — | — | — | | | | | | June 30, 2024 | 119 | — | — | 119 | | | | | |
(1) This amount corresponds to the additional invoice received from Orega Biotech for the rights relating to IPH5201 following the first patient dosed in the Phase 2 MATISSE clinical trial in June 2023, in accordance to the agreement signed in 2019. This additional invoice is fully amortized as of June 30, 2023 and paid on July 2023. (2) As of June 30, 2024, this amount included the amortization of rights related to the monalizumab for an amount of €294 thousand. As of June 30, 2023, this amount includes the amortization of the additional payment made to Orega Biotech in 2023 for and amount of €2,000 thousand and the amortization of rights related to the monalizumab for an amount of €651 thousand.
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v3.24.2.u1
Property and equipment (Tables)
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6 Months Ended |
Jun. 30, 2024 |
Property, plant and equipment [abstract] |
|
Disclosure of detailed information about property, plant and equipment |
| | | | | | | | | | | | | | | | | | (in thousands of euro) | Lands and buildings | Laboratory equipment and other | In progress | Total | Of which right of use assets | | | | | | | January 1, 2023 | 4,242 | 4,298 | — | 8,542 | 6,423 | Acquisitions | 31 | 279 | — | 310 | 79 | Disposals (1) | (513) | (78) | — | (591) | (513) | Depreciation | (323) | (670) | — | (993) | (428) | Transfers | — | — | — | — | — | | | | | | | June 30, 2023 | 3,437 | 3,829 | — | 7,268 | 5,561 | | | | | | | | | | | | | (in thousands of euro) | Lands and buildings | Laboratory equipment and other | In progress | Total | Of which right of use assets | | | | | | | January 1, 2024 | 2,958 | 3,378 | — | 6,322 | 5,055 | Acquisitions | 15 | 267 | 3 | 285 | 37 | Disposals | — | (18) | — | (18) | (18) | Depreciation | (352) | (493) | — | (845) | (392) | Transfers | — | — | — | — | — | | | | | | | June 30, 2024 | 2,621 | 3,134 | 3 | 5,748 | 4,682 |
(1) As a reminder, on March 13, 2023, the Company signed an amendment to the lease for the "Le Virage" building, reducing the surface area of the leased premises. The effective date of the lease amendment is March 15, 2023. As a result, and in accordance with IFRS 16, the impact on the consolidated balance sheet at the effective date of the lease amendment is as follows: write-off of a right of use (asset) of €0.5 million and a lease liability of €0.7 million.
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v3.24.2.u1
Trade payables and others (Tables)
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6 Months Ended |
Jun. 30, 2024 |
Subclassifications of assets, liabilities and equities [abstract] |
|
Disclosure of trade payables and others |
| | | | | | | | | (in thousands of euro) | June 30, 2024 | December 31, 2023 | | | | Suppliers (excluding payables related to capital expenditures) | 8,751 | 8,561 | Tax and employee-related payables (1) | 6,013 | 7,021 | Other payables (2) | 1,109 | 1,436 | Trade payables and others (excluding payables related to capital expenditures) | 15,873 | 17,018 | Payables related to capital expenditures | — | — | Payables and others | 15,873 | 17,018 |
(1) As of December 31, 2023, tax and employee related payables included a liability accrual of €1.4 million following the notification received as part of the tax inspection relating to accounting and research tax credits for the 2018 to 2020 financial years. The liability recognized as of June 30, 2024 in connection with notification is €0.4 million following the payment of €0.7 million in February 2024 and the offset of €0.3 million against the 2020 research tax credit receivable initially recognized for €13.0 million and finally collected in July 2024 for €12.7 million. (2) As of June 30, 2024 an December 31, 2023, this amount includes mainly the liability related to the payment of the guarantee fees on the two State Guaranteed Loans obtained from Société Générale and BNP Paribas in 2021 (see note 9).
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v3.24.2.u1
Financial liabilities (Tables)
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6 Months Ended |
Jun. 30, 2024 |
Subclassifications of assets, liabilities and equities [abstract] |
|
Disclosure of financial liabilities per maturity |
| | | | | | | | | | | | | | | | | | | | | (in thousands of euro) | December 31, 2023 | Proceeds from borrowing | Proceeds from lease liabilities and other non cash effects | Repayments of borrowings/leases liabilities | Exchange rate variation (non cash) | June 30, 2024 | State guaranteed loan Société Générale (1) | 20,000 | — | — | (2,432) | — | 17,568 | State guaranteed loan BNP Paribas (1) | 8,700 | — | — | (1,070) | — | 7,630 | State guaranteed loans - accrued interest | 14 | — | 13 | (14) | — | 13 | | | | | | | | Lease liabilities – Building "Le Virage" (3) | 375 | — | — | (121) | — | 254 | Lease liabilities – Premises Innate Inc. | 246 | — | — | (47) | 8 | 207 | Lease liabilities – Laboratory equipment | 109 | — | — | (83) | — | 26 | Lease liabilities – Vehicles | 85 | — | 19 | (17) | — | 87 | Lease liabilities - Printers | 18 | — | — | (4) | — | 13 | Borrowing – Equipment | 99 | — | — | (28) | — | 71 | Borrowing – Building (2) | 10,247 | — | 17 | (630) | — | 9,634 | Total | 39,893 | — | 49 | (4,446) | 8 | 35,503 |
| | | | | | | | | | | | | | | | | | | | | (in thousands of euro) | December 31, 2022 | Proceeds from borrowing | Proceeds from lease liabilities and other non cash effects | Repayments of borrowings/leases liabilities | Exchange rate variation (non cash) | June 30, 2023 | State guaranteed loan Société Générale (1) | 20,000 | — | — | — | — | 20,000 | State guaranteed loan BNP Paribas (1) | 8,700 | — | — | — | — | 8,700 | State guaranteed loans - accrued interest | 15 | — | — | — | — | 15 | Lease liabilities – Building "Le Virage" | 1,353 | — | (736) | (130) | — | 487 | Lease liabilities – Premises Innate Inc. | 345 | — | — | (50) | 2 | 297 | Lease liabilities – Laboratory equipment | 287 | — | — | (89) | — | 198 | Lease liabilities – Vehicles | 33 | — | 48 | (13) | — | 70 | Lease liabilities - Printers | 27 | — | — | (4) | — | 23 | Borrowing – Equipment | 154 | — | — | (27) | — | 127 | Borrowing – Building (2) | 11,338 | — | — | (602) | — | 10,736 | Total | 42,251 | — | (689) | (916) | 2 | 40,658 |
(1) As a reminder, on January 5, 2022, the Company announced that it had obtained €28.7 million in non-dilutive financing in the form of two State Guaranteed Loans from Société Générale (€20.0 million) and BNP Paribas (€8.7 million). The Company received the funds related to these two loans on December 27 and 30, 2021 respectively. Both loans have an initial maturity of one year with an option to extend to five years usable from August, 2022. They are 90% guaranteed by the French government as part of the package of measures put in place by the French government to support companies during the COVID-19 pandemic. In August 2022, the Company has requested the extension of these two loans repayment for an additional period of five years starting in 2022 and including a one-year grace period. Consequently, the Company has obtained agreements from Société Générale and BNP Paribas. The effective interest rates applied to these contracts during the additional period are 1.56% and 0.95% for Société Générale and BNP Paribas loans, respectively, excluding insurance and guarantee fees, with an amortization exemption for the entire year 2023. During this grace period, the Company will only be liable for the payment of interest and the guarantee fees. The amortization of the two loans began in 2024 for a period of four years. The state guarantee fees amounts to €877 thousand and €379 thousand for Société Générale and BNP Paribas loans respectively. (2) On July 3, 2017, the Company borrowed from the Bank “Société Générale” in order to finance the construction of its future headquarters. This loan amounting to a maximum of €15,200 thousand will be raised during the period of the construction in order to pay the supplier payments as they become due. As of December 31, 2018 and 2019, the loan was raised at an amount of €1,300 thousand. The loan release period was limited to August 30, 2019. On August 30, 2019, the Company drew down the remaining portion of the €15,200 thousand loan granted, for an amount of €13,900 thousand. The reimbursement of the capital has begun in August 30, 2019 and will proceed until August 30, 2031 (12 years). Given the development of its portfolio and in particular the refocusing of its activities on research and development, the Company has for the time being suspended the project to build its new head office on the land acquired in Luminy. In the meantime, the loan will be used to finance several structuring projects (improvement of the information system, development of a commercial platform, development of additional premises rented, etc.). As of June 30, 2024, the remaining capital of the loan amounted to €9,617 thousand. The Company authorized collateral over financial “Société Générale” instruments amounting to €15,200 thousand. The security interest on the pledge financial instruments will be released in accordance with the following schedule: €4,200 thousand in July 2024, €5,000 thousand in August 2027 and €6,000 thousand in August 2031. Following the release of the pledge on the €4.2m financial instrument that had reached maturity, the company received this amount in July 2024. This loan bears a fixed interest rate of 2.01%. It is subject to a covenant based on the assumption that the total cash, cash equivalents and current and non-current financial assets are at least equal to principal as of financial year end. (3) As a reminder, on March 13, 2023, the Company signed an amendment to the lease for the "Le Virage" building, reducing the surface area of the leased premises. The effective date of the lease amendment is March 15, 2023. As a result, and in accordance with IFRS 16, the impact on the consolidated balance sheet at the effective date of the lease amendment is as follows: write-off of a right of use (asset) of €0.5 million and a lease liability of €0.7 million.
|
Disclosure of maturity analysis for non-derivative financial liabilities |
The table below shows the schedule for the contractual repayment of financial liabilities (being principal and interest payments) as of June 30, 2024: | | | | | | | | | | | | | | | (in thousands of euro) | Within 1 year | From 2nd to 5th year included | Over 5 years | Total | | | | | | | | | | | | | | | | | | | | | State guaranteed loan Société Générale | 5,167 | 12,918 | — | 18,086 | State guaranteed loan BNP Paribas | 2,222 | 5,551 | — | 7,773 | State guaranteed loans - accrued interest | — | — | — | — | Lease liabilities – Building "Le Virage" | 254 | — | — | 254 | Lease liabilities – Premises Innate Inc. | 100 | 111 | — | 211 | Lease liabilities – Laboratory equipment | 26 | — | — | 26 | Lease liabilities – Vehicles | 34 | 59 | — | 92 | Lease liabilities - Printers | 9 | 4 | — | 13 | Borrowing – Equipment | 57 | 14 | — | 71 | Borrowing – Building | 1,545 | 5,587 | 3,210 | 10,342 | Total financial liabilities | 9,414 | 24,245 | 3,210 | 36,869 |
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v3.24.2.u1
Employee benefit (Tables)
|
6 Months Ended |
Jun. 30, 2024 |
Disclosure of information about defined benefit plans [abstract] |
|
Disclosure of defined benefit plans |
Defined benefit obligation | | | | | | | | | (in thousands of euro) | June 30, 2024 | December 31, 2023 | | | | Allowance for retirement defined benefit | 2,118 | 2,064 | Allowance for seniority awards | 352 | 377 | Defined benefit obligations | 2,470 | 2,441 |
|
Disclosure of net defined benefit liability (asset) |
Amounts recognized in the statement of financial position are determined as follows (in thousand euros): | | | | | | As of January 1, 2023 | 2,550 | | | | | | | | | | | Service cost | 312 | Payments (benefits and contributions paid by the employer) | (27) | Actuarial (gain) / loss | (394) | | | As of December 31, 2023 | 2,441 | | | Service cost | 166 | Payments (benefits and contributions paid by the employer) | (22) | Actuarial (gain) / loss | (116) | | | As of June 30, 2024 | 2,470 |
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v3.24.2.u1
Capital (Tables)
|
6 Months Ended |
Jun. 30, 2024 |
Share Capital and Share Base Payments [Abstract] |
|
Disclosure of number and weighted average exercise prices of other equity instruments |
The Company has issued BSAs, BSAARs, AGAs and AGAPs as follows: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Date | | Types | | Number of warrants issued as of 6/30/2024 | | Number of warrants void as of 6/30/2024 | | Number of warrants exercised as of 6/30/2024 | | Number of warrants outstanding as of 6/30/2024 | | Maximum number of shares to be issued as of 6/30/2024 | | Exercise price per share (in €) | Sept. 9, 2011 | | BSAAR 2011 | | 650,000 | | 25,000 | | 625,000 | | — | | — | | 2.04 | May 27, 2013 | | BSAAR 2012 | | 146,050 | | 12,250 | | 133,800 | | — | | — | | 2.04 | July 1, 2015 | | BSAAR 2015 | | 1,050,382 | | 2,720 | | 1,940 | | 1,045,722 | | 1,045,722 | | 7.20 | October 21, 2016 | | AGAP Management 2016-1 | | 2,000 | | 550 | | 250 | | 1,200 | | 156,000 | | - |
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | October 21, 2016 | | AGAP Employees 2016-1 | | 2,486 | | 251 | | 172 | | 2,063 | | 268,190 | | - | October 21, 2016 | | AGA Management 2016-1 | | 50,000 | | — | | 50,000 | | — | | — | | - | December 30, 2016 | | AGAP Management 2016-2 | | 3,000 | | — | | — | | 3,000 | | 333,000 | | - | December 30, 2016 | | AGA Management 2016-2 | | 250,000 | | — | | 250,000 | | — | | — | | - | April 3,2018 | | AGAP Employees 2017-1 | | 5,725 | | 5,725 | | — | | — | | — | | - | April 3,2018 | | AGAP Management 2017-1 | | 2,400 | | 2,400 | | — | | — | | — | | — | April 3,2018 | | AGA Employees 2017 | | 114,500 | | 4,000 | | 110,500 | | — | | — | | — | July 3, 2018 | | AGA Bonus 2018-1 | | 67,028 | | 469 | | 66,559 | | — | | — | | - | November 20, 2018 | | AGAP Perf Employees 2018-1 | | 327,500 | | 224,375 | | 103,125 | | — | | — | | - | November 20, 2018 | | AGAP Perf Management 2018-1 | | 260,000 | | 150,000 | | 110,000 | | — | | — | | - | January 14, 2019 | | AGA Employees 2018 | | 90,650 | | 5,000 | | 85,650 | | — | | — | | - | April 29, 2019 | | AGA New Members 2017-1 | | 25,000 | | — | | 25,000 | | — | | — | | - | July 3, 2019 | | AGA Bonus 2019-1 | | 57,376 | | — | | 57,376 | | — | | — | | - | July 13, 2020 | | AGA Bonus 2020-1 & 2 | | 79,861 | | 17,885 | | 61,976 | | — | | — | | - | August 5, 2020 | | AGAP Employees 2020-1 | | 766,650 | | 681,420 | | 85,230 | | — | | — | | - | August 5, 2020 | | AGAP Management 2020-1 | | 710,000 | | 580,000 | | 130,000 | | — | | — | | - | July 22, 2021 | | AGA Bonus 2021-1 | | 125,748 | | — | | 125,748 | | — | | — | | - | October 1, 2021 | | AGAP Employees 2021-1 | | 1,066,600 | | 290,800 | | — | | 775,800 | | 775,800 | | - | October 1, 2021 | | AGAP Management 2021-1 | | 610,000 | | 130,000 | | — | | 480,000 | | 480,000 | | - | February 12, 2022 | | AGA "Plan Epargne Entreprise" 2022 | | 138,960 | | — | | 138,960 | | — | | — | | — | October 3, 2022 | | AGA Bonus 2022-1 | | 128,061 | | — | | 128,061 | | — | | — | | — | December 12, 2022 | | AGA Perf Employees 2022-1 | | 1,371,500 | | 275,000 | | — | | 1,096,500 | | 1,096,500 | | — | December 12, 2022 | | AGA Perf Management 2022-1 | | 550,000 | | — | | — | | 550,000 | | 550,000 | | — | April 14, 2023 | | AGA "Plan Epargne Entreprise" 2023 | | 163,293 | | — | | 163,293 | | — | | — | | — | November 2, 2023 | | AGA New members 2023-1 | | 25,000 | | — | | — | | 25,000 | | 25,000 | | — | December 21, 2023 | | AGA Perf Employees 2023-1 | | 1,403,500 | | 66,250 | | — | | 1,337,250 | | 1,337,250 | | — | December 21, 2023 | | AGA Perf Management 2023-1 | | 750,000 | | — | | — | | 750,000 | | 750,000 | | — | February 15, 2024 | | AGA New members 2024-1 | | 25,000 | | — | | — | | 25,000 | | 25,000 | | — | June 10, 2024 | | AGA "Plan Epargne Entreprise" 2024 | | 68,744 | | — | | 68,744 | | — | | — | | — | July 21, 2020 | | Stock Options 2020-1 | | 102,000 | | 102,000 | | — | | — | | — | | - | November 4, 2019 | | AGAP 2019 Employees 2019 | | 546,700 | | 375,150 | | 171,550 | | — | | — | | - | November 4, 2019 | | AGAP 2019 Management 2019 | | 355,000 | | 207,500 | | 147,500 | | — | | — | | - | July 29, 2011 | | BSA 2011-2 | | 225,000 | | 25,000 | | 200,000 | | — | | — | | 1.77 | July 17, 2013 | | BSA 2013 | | 237,500 | | 12,500 | | 225,000 | | — | | — | | 2.36 | July 16, 2014 | | BSA 2014 | | 150,000 | | — | | 75,000 | | 75,000 | | 75,000 | | 8.65 | April 27, 2015 | | BSA 2015-1 | | 70,000 | | — | | — | | 70,000 | | 70,000 | | 9.59 | July 1, 2015 | | BSA 2015-2 | | 14,200 | | — | | — | | 14,200 | | 14,200 | | 14.05 |
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | September 20, 2017 | | BSA 2017 | | 37,000 | | — | | — | | 37,000 | | 37,000 | | 11.00 | December 16, 2022 | | BSA 2022-1 | | 40,000 | | 31,740 | | — | | 8,260 | | 8,260 | | 2.31 | December 15, 2023 | | BSA 2023-1 | | 50,000 | | 12,000 | | — | | 38,000 | | 38,000 | | 2.26 | | | June 30, 2024 | | 12,914,414 | | 3,239,985 | | 3,340,434 | | 6,333,995 | | 7,084,922 | | |
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v3.24.2.u1
Financial instruments recognized in the statement of financial position and related effect on the income statement (Tables)
|
6 Months Ended |
Jun. 30, 2024 |
Disclosure of detailed information about financial instruments [abstract] |
|
Disclosure of detailed information about financial instruments |
The following tables show the carrying amounts and fair values of financial assets and financial liabilities. The tables do not include fair value information for financial assets and financial liabilities not measured at fair value if the carrying amount is a reasonable approximation of fair value.
| | | | | | | | | | | | | | | As of June 30, 2024 | Book value on the statement of financial position | Fair value through profit and loss (1) | Amortized cost (2) | Fair value | Financial assets | | | | | Non-current financial assets | 10,350 | 10,350 | — | 10,350 | Trade receivables and others | 34,273 | — | 34,273 | 34,273 | Short-term investments | 21,809 | 21,809 | — | 21,809 | Cash and cash equivalents | 69,990 | 69,990 | — | 69,990 | Total financial assets | 136,422 | 102,149 | 34,273 | 136,422 | Financial liabilities | | | | | Financial liabilities—non-current portion | 26,574 | — | 26,574 | 26,574 | Financial liabilities—current portion | 8,929 | — | 8,929 | 8,929 | Trade payables and others | 15,873 | — | 15,873 | 15,873 | Total financial liabilities | 51,376 | — | 51,376 | 51,376 |
| | | | | | | | | | | | | | | As of December 31, 2023 | Book value on the statement of financial position | Fair value through profit and loss (1) | Amortized Cost (2) | Fair value | Financial assets | | | | | Non-current financial assets | 9,796 | 9,796 | — | 9,796 | Trade receivables and others | 66,111 | — | 66,111 | 66,111 | Short-term investments | 21,851 | 21,851 | — | 21,851 | Cash and cash equivalents | 70,605 | 70,605 | — | 70,605 | Total financial assets | 168,363 | 102,252 | 66,111 | 168,363 | Financial liabilities | | | | | Financial liabilities—non-current portion | 30,957 | — | 30,957 | 30,957 | Financial liabilities—current portion | 8,936 | — | 8,936 | 8,936 | Trade payables and others | 17,018 | — | 17,018 | 17,018 | Total financial liabilities | 56,911 | — | 56,911 | 56,911 |
(1) The fair value of financial assets classified as fair value through profit and loss corresponds to the market value of the assets, which are primarily determined using level 2 measurements.
(2) The book amount of financial assets and liabilities measured at amortized cost was deemed to be a reasonable estimation of fair value.
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v3.24.2.u1
Revenue and other income (Tables)
|
6 Months Ended |
Jun. 30, 2024 |
Disclosure of disaggregation of revenue from contracts with customers [abstract] |
|
Disclosure of revenue from collaboration and licensing agreements |
Revenues from collaboration and licensing agreements result from agreements signed with AstraZeneca, Sanofi and Takeda :
| | | | | | | | | (in thousands of euro) | June 30, 2024 | June 30, 2023 | | | | Proceeds from collaboration and licensing agreements | 7,396 | 34,728 | of which monalizumab agreement (AstraZeneca) | 2,994 | 9,503 | | | | | | | of which 2016 Sanofi agreement | 4,000 | 2,000 | of which Sanofi agreement 2022 - ANKET IPH62 - Recognition of license initial payment and income related to the completion of work in line with the joint research program | 199 | 18,672 | of which Sanofi agreement 2022 - ANKET IPH67 -Recognition of license initial payment, income related to the option exercise and income related to the completion of work in line with the joint research program | 203 | — | of which Takeda agreement | — | 4,553 | | | | Invoicing of R&D costs (IPH5201 agreement) | 897 | 616 | | | | Revenue from collaboration and licensing agreements | 8,293 | 35,344 |
|
Disclosure of change in deferred revenue and collaboration liabilities |
Change in deferred revenue relating to monalizumab agreement: | | | | | | (in thousands of euro) | Total | As of December 31, 2022 | 14,481 | | | Revenue for the six months ended June 30, 2023 | (9,503) | Transfer from / (to) collaboration liabilities | (283) | As of June 30, 2023 | 4,695 | | | As of December 31, 2023 | 5,156 | | | Revenue for the six months ended June 30, 2024 | (2,994) | Transfer from / (to) collaboration liabilities | (172) | As of June 30, 2024 | 1,990 |
Change in collaboration liabilities relating to monalizumab agreement: | | | | | | (in thousands of euro) | Total | As of December 31, 2022 | 63,211 | Additions | 283 | Deductions | (7,436) | As of June 30, 2023 | 56,058 | | | As of December 31, 2023 | 52,677 | Additions | 1,891 | Deductions | (2,419) | As of June 30, 2024 | 52,149 |
Change in deferred revenue relating to the 2022 research collaboration and licensing agreement : | | | | | | (in thousands of euro) | Total | As of December 31, 2022 | — | Additions (1) | 6,500 | Deductions | (172) | As of June 30, 2023 | 6,328 | | | | | | | | |
| | | | | | (in thousands of euro) | Total | As of December 31, 2023 | 5,327 | Additions | — | Deductions | (402) | As of June 30, 2024 | 4,925 | | | | | | | | |
(1) The increase in deferred revenue relating to the 2022 research collaboration and licensing agreement with Sanofi between December 31, 2022 and June 30, 2023 mainly comprises (i) an upfront payment of €5,000 thousand relating to the granting of two options for exclusive licenses on Innate's intellectual property for the research, development, manufacturing and commercialization of NKCEs specifically targeting two preclinical molecules. The Company will recognize the related revenues either at the reporting date or three years after the effective date; as well as (ii) an amount of €1,500 thousand relating to research activities to perform in collaboration with Sanofi. The Company will recognize the related revenues on a straight-line basis over the duration of the research work to which the Company has agreed.
|
Disclosure of variance of deferred revenue |
Schedule of variance of deferred revenue | | | | | | | | | | | | | | | | | | (in thousands of euro) | As of December 31, 2023 | Recognition in P&L | Proceeds | Transfer from / (to) collaboration liabilities | As of June 30, 2024 | Monalizumab | 5,155 | (2,994) | — | (172) | 1,990 | | | | | | | Sanofi (2022) option | 2,500 | — | — | — | 2,500 | Sanofi (2022) services | 2,826 | (402) | — | — | 2,424 | | | | | | | Total | 10,481 | (3,396) | — | (172) | 6,915 |
| | | | | | | | | | | | | | | | | | (in thousands of euro) | As of December 31, 2022 | Recognition in P&L | Proceeds | Transfer from / (to) collaboration liabilities | As of June 30, 2023 | Monalizumab | 14,481 | (9,503) | — | (283) | 4,696 | | | | | | | Sanofi (2022) option | — | — | 5,000 | — | 5,000 | Sanofi (2022) services | — | (172) | 1,500 | — | 1,328 | Total | 14,481 | (9,675) | 5,000 | (283) | 11,024 |
|
Disclosure of government financing for research expenditures |
The total amount for government financing for research expenditures recorded as other income in the income statement can be analysed as follows: | | | | | | | | | (in thousands of euro) | June 30, 2024 | June 30, 2023 | | | | Research tax credit | 4,050 | 4,854 | Grant | 2 | — | Government financing for research expenditures | 4,052 | 4,854 |
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v3.24.2.u1
Operating expenses (Tables)
|
6 Months Ended |
Jun. 30, 2024 |
Analysis of income and expense [abstract] |
|
Disclosure of expenses by nature |
Operating expenses | | | | | | | | | | | | | | | | | | | | | (in thousands of euro) | June 30, 2024 | June 30, 2023 | | R&D | G&A | Total | R&D | G&A | Total | Subcontracting costs(1) | (15,585) | — | (15,585) | (15,857) | — | (15,857) | Cost of supplies and consumable materials | (1,485) | (153) | (1,638) | (1,410) | (100) | (1,510) | Personnel expenses other than share-based compensation | (7,532) | (3,470) | (11,002) | (7,781) | (3,871) | (11,652) | Share-based compensation | (1,175) | (531) | (1,706) | (905) | (496) | (1,401) | Personnel expenses | (8,707) | (4,001) | (12,708) | (8,686) | (4,367) | (13,053) | Non-scientific advisory and consulting(2) | (124) | (1,934) | (2,058) | (532) | (1,662) | (2,194) | Leasing and maintenance | (490) | (710) | (1,200) | (470) | (445) | (915) | Travel expenses and meeting attendance | (272) | (151) | (423) | (180) | (143) | (323) | Marketing, communication and public relations | (16) | (164) | (180) | (34) | (142) | (176) | Scientific advisory and consulting(3) | (933) | — | (933) | (561) | — | (561) | Other purchases and external expenses | (10) | (1,125) | (1,135) | (13) | (1,153) | (1,166) | Depreciation and amortization | (643) | (503) | (1,146) | (3,044) | (601) | (3,645) | Intellectual property expenses | (568) | (128) | (696) | (570) | (68) | (638) | Other income and (expenses), net | (242) | (714) | (956) | (98) | (464) | (562) | | | | | | | | Total operating expenses | (29,076) | (9,582) | (38,657) | (31,453) | (9,144) | (40,597) |
(1)The Company subcontracts a significant part of its pre-clinical (pharmaceutical development, tolerance studies and other model experiments, etc.) and clinical operations (coordination of trials, hospital costs, etc.) to third parties. (2)Non-scientific advisory and consulting are services performed to support the general and administration activities of the Company, such as legal, accounting and audit fees as well as business development support. (3)Scientific advisory and consulting expenses relate to consulting services performed by third parties to support the research and development activities of the Company.
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v3.24.2.u1
Net financial income / (loss) (Tables)
|
6 Months Ended |
Jun. 30, 2024 |
Analysis of income and expense [abstract] |
|
Disclosure of net financial income (loss) |
Net financial income (loss) can be analyzed as follows : | | | | | | | | | (in thousands of euro) | June 30, 2024 | June 30, 2023 | | | | Interests on financial assets | 1,269 | 965 | Change in valuation allowance on financial instruments | 1,471 | 1,044 | Foreign exchange gains | 873 | 1,073 | | | | Financial income | 3,613 | 3,083 | Foreign exchange losses | (1,763) | (642) | Unrealized losses on financial assets | — | — | Interest on financial liabilities | (300) | (324) | | | | Financial expenses | (2,064) | (966) | Net financial income (loss) | 1,549 | 2,116 |
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v3.24.2.u1
Related party transactions (Tables)
|
6 Months Ended |
Jun. 30, 2024 |
Related party transactions [abstract] |
|
Disclosure of key management personnel compensation |
For each of the period presented, the following compensation was granted to the members of the Executive Committee of the Company and were recognized as expense:
| | | | | | | | | (in thousands of euro) | June 30, 2024 | June 30, 2023 | | | | Personnel and other short-term employee benefits | 1,713 | 1,386 | Extra pension benefits | 21 | 11 | Share-based compensation | 519 | 408 | Advisory fees | — | 318 | Executive Board Members and other Executive Members compensation | 2,253 | 2,123 |
|
Disclosure of transactions between related parties |
The payments between the two companies as well as the liabilities and receivables as of June 30, 2024 are as follows: | | | | | | | | | | As of June 30,2024 | (in thousands of euro) | Payments | Assets/Liabilities | | | | Collection (AstraZeneca to the Company) / Receivables | 1,657 | 394 | Payments (the Company to AstraZeneca) / Liabilities | (3,342) | (3,926) | Total | (1,685) | (3,532) |
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v3.24.2.u1
Income / (loss) per share (Tables)
|
6 Months Ended |
Jun. 30, 2024 |
Income (Loss) Per Share [Abstract] |
|
Summary of income (loss) per share |
Basic income / (loss) per share are calculated by dividing the net earnings attributable to equity holders of the Company by the weighted average number of ordinary shares in issue during the period.
| | | | | | | | | | June 30, 2024 | June 30, 2023 | | | | Net income/(loss) | (24,764) | 1,718 | Weighted average number of ordinary shares in circulation | 80,872,369 | 80,319,897 | Basic income/(loss) per share (€ per share) | (0.31) | 0.02 |
Diluted income (loss) per share is calculated by dividing the net income (loss) attributable to equity holders of the Company by the weighted average number of ordinary shares in circulation during the corresponding period, increased by all dilutive potential common shares.
| | | | | | | | | In thousands of euro, except for data share | June 30, 2024 | June 30, 2023 | Net income/(loss) for the period | (24,764) | 1,718 | Weighted average number of ordinary shares in circulation | 80,872,369 | 80,319,897 | Adjustment for share instruments | 5,026,389 | 3,461,439 | Diluted income/(loss) per share (€ per share) | (0.31) | 0.02 |
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v3.24.2.u1
The Company and key events - The company (Details) € in Thousands |
6 Months Ended |
|
|
Jun. 30, 2024
EUR (€)
employee
subsidiary
|
Jun. 30, 2023
EUR (€)
employee
|
Dec. 31, 2023
EUR (€)
|
Dec. 31, 2022
EUR (€)
|
Company Information [Abstract] |
|
|
|
|
Net loss for the period |
€ (24,764)
|
€ 1,718
|
|
|
Total shareholders’ equity |
€ 28,796
|
€ 57,863
|
€ 51,901
|
€ 54,151
|
Number of subsidiaries | subsidiary |
1
|
|
|
|
Number of employees | employee |
168
|
191
|
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The Company and key events - Key events for the six-month period ended June 30, 2024 (Details)
|
|
6 Months Ended |
Jun. 10, 2024
EUR (€)
share
€ / shares
|
Jun. 30, 2024
EUR (€)
€ / shares
|
Jun. 30, 2023
EUR (€)
|
Disclosure of disaggregation of revenue from contracts with customers [line items] |
|
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) | share |
106,844
|
|
|
Exercise and subscription of equity instruments | € |
|
€ 93,000
|
€ 348,000
|
Ordinary Shares |
|
|
|
Disclosure of disaggregation of revenue from contracts with customers [line items] |
|
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) | share |
38,100
|
|
|
Par value per share (in EUR per share) | € / shares |
|
€ 0.05
|
|
Free Shares |
|
|
|
Disclosure of disaggregation of revenue from contracts with customers [line items] |
|
|
|
Share issued, price per share (in EUR per share) | € / shares |
€ 2.45
|
|
|
Exercise Of Share Warrants | Ordinary Shares |
|
|
|
Disclosure of disaggregation of revenue from contracts with customers [line items] |
|
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) | share |
68,744
|
|
|
Definitive Acquisition Of Free Shares |
|
|
|
Disclosure of disaggregation of revenue from contracts with customers [line items] |
|
|
|
Par value per share (in EUR per share) | € / shares |
€ 0.05
|
|
|
Ordinary Shares |
|
|
|
Disclosure of disaggregation of revenue from contracts with customers [line items] |
|
|
|
Par value per share (in EUR per share) | € / shares |
€ 0.05
|
|
|
Issued capital free of subscription |
|
|
|
Disclosure of disaggregation of revenue from contracts with customers [line items] |
|
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) | share |
68,744
|
|
|
Share premium |
|
|
|
Disclosure of disaggregation of revenue from contracts with customers [line items] |
|
|
|
Exercise and subscription of equity instruments | € |
|
€ 88,003
|
333,000
|
Share premium | Free Shares |
|
|
|
Disclosure of disaggregation of revenue from contracts with customers [line items] |
|
|
|
Exercise and subscription of equity instruments | € |
€ 91,440
|
|
|
Agreement with Sanofi, 2016 |
|
|
|
Disclosure of disaggregation of revenue from contracts with customers [line items] |
|
|
|
Milestone payment received | € |
|
€ 4,000,000
|
€ 2,000,000
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v3.24.2.u1
Cash, cash equivalents, short-term investments and non-current financial assets - Disclosure of cash, cash equivalents and financial assets (Details) - EUR (€) € in Thousands |
Jun. 30, 2024 |
Dec. 31, 2023 |
Jun. 30, 2023 |
Dec. 31, 2022 |
Subclassifications of assets, liabilities and equities [abstract] |
|
|
|
|
Cash and cash equivalents |
€ 69,990
|
€ 70,605
|
€ 71,414
|
€ 84,225
|
Short-term investments |
21,809
|
21,851
|
|
|
Cash, cash equivalents and short-term investments |
91,799
|
92,456
|
|
|
Non-current financial assets |
10,350
|
9,796
|
€ 35,790
|
€ 35,119
|
Cash, cash equivalents and financial assets |
€ 102,149
|
€ 102,252
|
|
|
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v3.24.2.u1
Cash, cash equivalents, short-term investments and non-current financial assets - Additional information (Details) € in Thousands |
6 Months Ended |
|
Jun. 30, 2024
EUR (€)
Rate
shares
|
Jun. 30, 2023
EUR (€)
|
Dec. 31, 2023
EUR (€)
|
Disclosure of financial assets [Line Items] |
|
|
|
Number of SICAV held (in units/shares) | shares |
3
|
|
|
Cash, cash equivalents and financial assets |
€ 102,149
|
|
€ 102,252
|
Non-current financial assets, variation of fair value through the consolidated statement of income (loss) |
553
|
€ 772
|
|
Short-term investments, variation of fair value through the consolidated statement of income (loss) |
€ 438
|
€ 271
|
|
SICAV and mutual funds | Minimum |
|
|
|
Disclosure of financial assets [Line Items] |
|
|
|
Risk profile rate | Rate |
1
|
|
|
SICAV and mutual funds | Maximum |
|
|
|
Disclosure of financial assets [Line Items] |
|
|
|
Risk profile rate | Rate |
7
|
|
|
Cash, cash equivalents, and financial assets denominated in US dollars |
|
|
|
Disclosure of financial assets [Line Items] |
|
|
|
Cash, cash equivalents and financial assets |
€ 18,221
|
|
€ 20,798
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v3.24.2.u1
Cash, cash equivalents, short-term investments and non-current financial assets - Disclosure of reconciliation of changes in short-term investments and non-current financial assets (Details) - EUR (€) € in Thousands |
6 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
Short-term investments |
|
|
Beginning balance, current investments |
€ 21,851
|
€ 17,260
|
Short-term investments, acquisitions |
0
|
0
|
Short-term investments, disposals |
(1,215)
|
0
|
Short-term investments, variation of fair value through the consolidated statement of income (loss) |
438
|
271
|
Short-term investments, variation of accrued interest |
212
|
232
|
Short-term investments, foreign currency effect |
524
|
(288)
|
Ending balance, current investments |
21,810
|
17,475
|
Non-current financial assets |
|
|
Beginning balance, non-current financial assets |
9,796
|
35,119
|
Non-current financial assets, acquisitions |
0
|
0
|
Non-current financial assets, disposals |
0
|
0
|
Non-current financial assets, variation of fair value through the consolidated statement of income (loss) |
553
|
772
|
Non-current financial assets, variation of accrued interest |
0
|
(102)
|
Non-current financial assets, foreign currency effect |
0
|
0
|
Ending balance, non-current financial assets |
10,350
|
35,790
|
Total |
|
|
Beginning balance, total |
31,647
|
52,379
|
Total, acquisitions |
0
|
0
|
Total, disposals |
(1,215)
|
0
|
Total, variation of fair value through the consolidated statement of income (loss) |
991
|
1,043
|
Total variance of accrued interest |
212
|
130
|
Total, foreign currency effect |
524
|
(288)
|
Ending balance, total |
€ 32,160
|
€ 53,265
|
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v3.24.2.u1
Trade receivables and others - Disclosure of trade receivables and others (Details) € in Thousands |
|
6 Months Ended |
12 Months Ended |
Aug. 31, 2022
loan
|
Jun. 30, 2024
EUR (€)
loan_agreement
|
Dec. 31, 2023
EUR (€)
|
Dec. 31, 2020
EUR (€)
|
Dec. 31, 2019
EUR (€)
|
Disclosure of financial assets [Line Items] |
|
|
|
|
|
Other receivables |
|
€ 97
|
€ 104
|
|
|
Research tax credit |
|
12,755
|
29,755
|
|
|
Other tax credits |
|
0
|
361
|
|
|
Prepaid expenses, current |
|
3,009
|
5,692
|
|
|
VAT refund |
|
583
|
1,037
|
|
|
Trade account receivables |
|
393
|
15,233
|
|
|
Prepayments made to suppliers |
|
2,957
|
3,374
|
|
|
Receivables and others |
|
19,795
|
55,557
|
|
|
Research tax credit, non-current |
|
13,850
|
9,800
|
|
|
Prepaid expenses, non-current |
|
628
|
754
|
|
|
Receivables and others - non-current |
|
14,478
|
10,554
|
|
|
Trade receivables and others |
|
34,273
|
66,111
|
|
|
Income from research tax credit 2019 and 2020, maturity |
|
|
|
|
3 years
|
Income from research tax credit 2019 |
|
|
|
|
€ 16,737
|
Income from research tax credit 2020 |
|
|
|
€ 13,018
|
|
Offset of restated income from research tax credit |
|
263
|
|
|
|
Income from research tax credit 2023 |
|
|
9,800
|
|
|
Income from research tax credit HY 2024 |
|
€ 4,050
|
|
|
|
Carry-back tax receivable |
|
|
333
|
|
|
Agreement With Sanofi |
|
|
|
|
|
Disclosure of financial assets [Line Items] |
|
|
|
|
|
Trade account receivables |
|
|
15,000
|
|
|
State guaranteed loan, Societe Generale and BNP Paribas |
|
|
|
|
|
Disclosure of financial assets [Line Items] |
|
|
|
|
|
Borrowing, number of loan agreement |
2
|
2
|
|
|
|
Borrowing, maturity |
5 years
|
5 years
|
|
|
|
Guarantees |
|
|
|
|
|
Disclosure of financial assets [Line Items] |
|
|
|
|
|
Prepaid expenses, current |
|
€ 879
|
€ 1,005
|
|
|
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v3.24.2.u1
Intangible assets - Additional information (Details) $ in Millions |
|
1 Months Ended |
6 Months Ended |
|
|
Jun. 01, 2022
USD ($)
|
Jul. 31, 2023
EUR (€)
|
Oct. 31, 2022
EUR (€)
|
Jan. 31, 2022
EUR (€)
|
Oct. 31, 2020
EUR (€)
|
Jun. 30, 2020
EUR (€)
|
Apr. 30, 2020
EUR (€)
|
Jun. 30, 2019
EUR (€)
|
Jun. 30, 2024
EUR (€)
|
Jun. 30, 2023
EUR (€)
|
Dec. 31, 2022
EUR (€)
|
Dec. 31, 2023
EUR (€)
|
Jul. 31, 2017
EUR (€)
|
Disclosure of detailed information about intangible assets [line items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Intangible assets other than goodwill |
|
|
|
|
|
|
|
|
€ 119,000
|
€ 903,000
|
€ 1,556,000
|
€ 416,000
|
|
Additional considerations |
|
|
|
|
|
|
|
|
0
|
2,000,000
|
|
|
|
Financial liabilities |
|
|
|
|
|
|
|
|
35,503,000
|
€ 40,658,000
|
42,251,000
|
39,893,000
|
|
2014 Monalizumab (NKG2A) agreement with Novo Nordisk |
|
|
|
|
|
|
|
|
|
|
|
|
|
Disclosure of detailed information about intangible assets [line items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Intangible assets other than goodwill |
|
|
|
|
|
|
|
|
119,000
|
|
|
€ 416,000
|
|
IPH5201 (anti-CD39) rights acquired from Orega Biotech |
|
|
|
|
|
|
|
|
|
|
|
|
|
Disclosure of detailed information about intangible assets [line items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Additional considerations |
|
€ 2,000,000
|
€ 600,000
|
€ 400,000
|
|
€ 200,000
|
€ 2,500,000
|
€ 7,000,000
|
|
|
|
|
|
Agreement related to IPH5201 with AstraZeneca |
|
|
|
|
|
|
|
|
|
|
|
|
|
Disclosure of detailed information about intangible assets [line items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Milestone payment received | $ |
$ 5
|
|
|
|
|
|
|
|
|
|
|
|
|
IPH5401 (anti-C5aR) rights acquired from Novo Nordisk A/S |
|
|
|
|
|
|
|
|
|
|
|
|
|
Disclosure of detailed information about intangible assets [line items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Intangible assets other than goodwill |
|
|
|
|
|
|
|
|
|
|
|
|
€ 40,000,000
|
Payments for milestone |
|
|
|
|
€ 1,000,000
|
|
|
|
|
|
|
|
|
Financial liabilities |
|
|
|
|
|
|
|
|
€ 0
|
|
|
|
|
Impairment of intangible assets |
|
|
|
|
|
|
|
|
|
|
€ 41,000,000
|
|
|
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v3.24.2.u1
Property and equipment - Disclosure of detailed information about property, plant and equipment (Details) - EUR (€) € in Thousands |
|
6 Months Ended |
Mar. 15, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Reconciliation of changes in property, plant and equipment [abstract] |
|
|
|
Property, plant and equipment including right-of-use assets at beginning of period |
|
€ 6,322
|
€ 8,542
|
Acquisitions |
|
285
|
310
|
Disposals |
|
(18)
|
(591)
|
Depreciation |
|
(845)
|
(993)
|
Transfers |
|
0
|
0
|
Property, plant and equipment including right-of-use assets at end of period |
|
5,748
|
7,268
|
Right-of-use assets |
|
|
|
Reconciliation of changes in property, plant and equipment [abstract] |
|
|
|
Property, plant and equipment including right-of-use assets at beginning of period |
|
5,055
|
6,423
|
Acquisitions |
|
37
|
79
|
Disposals |
|
(18)
|
(513)
|
Depreciation |
|
(392)
|
(428)
|
Transfers |
|
0
|
0
|
Property, plant and equipment including right-of-use assets at end of period |
|
4,682
|
5,561
|
Write-off of right-of-use asset |
€ 500
|
|
|
Lease liabilities – Building "Le Virage" |
|
|
|
Reconciliation of changes in property, plant and equipment [abstract] |
|
|
|
Write-off of lease liability |
€ 700
|
|
|
Lands and buildings |
|
|
|
Reconciliation of changes in property, plant and equipment [abstract] |
|
|
|
Property, plant and equipment including right-of-use assets at beginning of period |
|
2,958
|
4,242
|
Acquisitions |
|
15
|
31
|
Disposals |
|
0
|
(513)
|
Depreciation |
|
(352)
|
(323)
|
Transfers |
|
0
|
0
|
Property, plant and equipment including right-of-use assets at end of period |
|
2,621
|
3,437
|
Laboratory equipment and other |
|
|
|
Reconciliation of changes in property, plant and equipment [abstract] |
|
|
|
Property, plant and equipment including right-of-use assets at beginning of period |
|
3,378
|
4,298
|
Acquisitions |
|
267
|
279
|
Disposals |
|
(18)
|
(78)
|
Depreciation |
|
(493)
|
(670)
|
Transfers |
|
0
|
0
|
Property, plant and equipment including right-of-use assets at end of period |
|
3,134
|
3,829
|
In progress |
|
|
|
Reconciliation of changes in property, plant and equipment [abstract] |
|
|
|
Property, plant and equipment including right-of-use assets at beginning of period |
|
0
|
0
|
Acquisitions |
|
3
|
0
|
Disposals |
|
0
|
0
|
Depreciation |
|
0
|
0
|
Transfers |
|
0
|
0
|
Property, plant and equipment including right-of-use assets at end of period |
|
€ 3
|
€ 0
|
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v3.24.2.u1
Trade payables and others - Disclosure of trade payables and others (Details) € in Thousands |
1 Months Ended |
6 Months Ended |
12 Months Ended |
|
Jul. 31, 2024
EUR (€)
|
Feb. 29, 2024
EUR (€)
|
Jun. 30, 2024
EUR (€)
loan
|
Dec. 31, 2020
EUR (€)
|
Dec. 31, 2023
EUR (€)
loan
|
Disclosure of trade payables and others [Line Items] |
|
|
|
|
|
Suppliers (excluding payables related to capital expenditures) |
|
|
€ 8,751
|
|
€ 8,561
|
Tax and employee-related payables |
|
|
6,013
|
|
7,021
|
Other current payables |
|
|
1,109
|
|
1,436
|
Trade payables and others (excluding payables related to capital expenditures) |
|
|
15,873
|
|
17,018
|
Payables related to capital expenditures |
|
|
0
|
|
0
|
Payables and others |
|
|
15,873
|
|
17,018
|
Current payables on social security and taxes other than income tax |
|
|
400
|
|
€ 1,400
|
Payment on social security and taxes other than income tax |
|
€ 700
|
|
|
|
Offset against income from research tax credit 2020 |
|
|
€ 300
|
|
|
Income from research tax credit 2020 |
|
|
|
€ 13,018
|
|
Number of state guaranteed loans | loan |
|
|
2
|
|
2
|
Forecast |
|
|
|
|
|
Disclosure of trade payables and others [Line Items] |
|
|
|
|
|
Income from research tax credit 2020, receivable |
€ 12,700
|
|
|
|
|
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v3.24.2.u1
Financial liabilities - Disclosure of financial liabilities per maturity (Details) € in Thousands |
|
|
|
|
|
1 Months Ended |
6 Months Ended |
|
|
|
|
Mar. 15, 2023
EUR (€)
|
Aug. 31, 2022
EUR (€)
loan
|
Jan. 05, 2022
EUR (€)
loan_agreement
|
Aug. 30, 2019
EUR (€)
|
Jul. 03, 2017
EUR (€)
|
Jul. 31, 2024
EUR (€)
|
Aug. 31, 2022
EUR (€)
loan
|
Jun. 30, 2024
EUR (€)
loan_agreement
|
Jun. 30, 2023
EUR (€)
|
Dec. 31, 2023
EUR (€)
|
Dec. 31, 2022
EUR (€)
|
Dec. 31, 2019
EUR (€)
|
Dec. 31, 2018
EUR (€)
|
Disclosure of financial liabilities [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Financial liabilities |
|
|
|
|
|
|
|
€ 35,503
|
€ 40,658
|
€ 39,893
|
€ 42,251
|
|
|
Proceeds from borrowing |
|
|
|
|
|
|
|
0
|
0
|
|
|
|
|
Proceeds from lease liabilities and other non cash effects |
|
|
|
|
|
|
|
49
|
(689)
|
|
|
|
|
Repayments of borrowings/leases liabilities |
|
|
|
|
|
|
|
(4,446)
|
(916)
|
|
|
|
|
Exchange rate variation (non cash) |
|
|
|
|
|
|
|
8
|
2
|
|
|
|
|
Current prepaid expenses |
|
|
|
|
|
|
|
3,009
|
|
5,692
|
|
|
|
Right-of-use assets |
|
|
|
|
|
|
|
|
|
|
|
|
|
Disclosure of financial liabilities [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Write-off of right-of-use asset |
€ 500
|
|
|
|
|
|
|
|
|
|
|
|
|
Guarantees |
|
|
|
|
|
|
|
|
|
|
|
|
|
Disclosure of financial liabilities [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Current prepaid expenses |
|
|
|
|
|
|
|
€ 879
|
|
1,005
|
|
|
|
State guaranteed loan, Societe Generale and BNP Paribas |
|
|
|
|
|
|
|
|
|
|
|
|
|
Disclosure of financial liabilities [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Borrowing, number of loan agreement |
|
2
|
|
|
|
|
2
|
2
|
|
|
|
|
|
Borrowing, maturity |
|
5 years
|
|
|
|
|
|
5 years
|
|
|
|
|
|
Borrowing, grace period |
|
1 year
|
|
|
|
|
|
|
|
|
|
|
|
State guaranteed loan Société Générale (1) |
|
|
|
|
|
|
|
|
|
|
|
|
|
Disclosure of financial liabilities [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Borrowing, maturity |
|
|
|
|
|
|
4 years
|
|
|
|
|
|
|
Borrowings, interest rate |
|
1.56%
|
|
|
|
|
1.56%
|
|
|
|
|
|
|
Number of loans | loan |
|
|
|
|
|
|
2
|
|
|
|
|
|
|
State guaranteed loan Société Générale (1) | Guarantees |
|
|
|
|
|
|
|
|
|
|
|
|
|
Disclosure of financial liabilities [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Current prepaid expenses |
|
€ 877
|
|
|
|
|
€ 877
|
|
|
|
|
|
|
State guaranteed loan BNP Paribas (1) |
|
|
|
|
|
|
|
|
|
|
|
|
|
Disclosure of financial liabilities [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Borrowings, interest rate |
|
0.95%
|
|
|
|
|
0.95%
|
|
|
|
|
|
|
State guaranteed loan BNP Paribas (1) | Guarantees |
|
|
|
|
|
|
|
|
|
|
|
|
|
Disclosure of financial liabilities [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Current prepaid expenses |
|
€ 379
|
|
|
|
|
€ 379
|
|
|
|
|
|
|
State guaranteed loan Société Générale (1) |
|
|
|
|
|
|
|
|
|
|
|
|
|
Disclosure of financial liabilities [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Financial liabilities |
|
|
|
|
|
|
|
€ 17,568
|
20,000
|
20,000
|
20,000
|
|
|
Proceeds from borrowing |
|
|
|
|
|
|
|
0
|
0
|
|
|
|
|
Proceeds from lease liabilities and other non cash effects |
|
|
|
|
|
|
|
0
|
0
|
|
|
|
|
Repayments of borrowings/leases liabilities |
|
|
|
|
|
|
|
(2,432)
|
0
|
|
|
|
|
Exchange rate variation (non cash) |
|
|
|
|
|
|
|
0
|
0
|
|
|
|
|
Notional amount |
|
|
€ 20,000
|
|
|
|
|
|
|
|
|
|
|
State guaranteed loan BNP Paribas (1) |
|
|
|
|
|
|
|
|
|
|
|
|
|
Disclosure of financial liabilities [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Financial liabilities |
|
|
|
|
|
|
|
7,630
|
8,700
|
8,700
|
8,700
|
|
|
Proceeds from borrowing |
|
|
|
|
|
|
|
0
|
0
|
|
|
|
|
Proceeds from lease liabilities and other non cash effects |
|
|
|
|
|
|
|
0
|
0
|
|
|
|
|
Repayments of borrowings/leases liabilities |
|
|
|
|
|
|
|
(1,070)
|
0
|
|
|
|
|
Exchange rate variation (non cash) |
|
|
|
|
|
|
|
0
|
0
|
|
|
|
|
Notional amount |
|
|
8,700
|
|
|
|
|
|
|
|
|
|
|
State guaranteed loans - accrued interest |
|
|
|
|
|
|
|
|
|
|
|
|
|
Disclosure of financial liabilities [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Financial liabilities |
|
|
|
|
|
|
|
13
|
15
|
14
|
15
|
|
|
Proceeds from borrowing |
|
|
|
|
|
|
|
0
|
0
|
|
|
|
|
Proceeds from lease liabilities and other non cash effects |
|
|
|
|
|
|
|
13
|
0
|
|
|
|
|
Repayments of borrowings/leases liabilities |
|
|
|
|
|
|
|
(14)
|
0
|
|
|
|
|
Exchange rate variation (non cash) |
|
|
|
|
|
|
|
0
|
0
|
|
|
|
|
Lease liabilities – Building "Le Virage" |
|
|
|
|
|
|
|
|
|
|
|
|
|
Disclosure of financial liabilities [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Financial liabilities |
|
|
|
|
|
|
|
254
|
487
|
375
|
1,353
|
|
|
Proceeds from borrowing |
|
|
|
|
|
|
|
0
|
0
|
|
|
|
|
Proceeds from lease liabilities and other non cash effects |
|
|
|
|
|
|
|
0
|
(736)
|
|
|
|
|
Repayments of borrowings/leases liabilities |
|
|
|
|
|
|
|
(121)
|
(130)
|
|
|
|
|
Exchange rate variation (non cash) |
|
|
|
|
|
|
|
0
|
0
|
|
|
|
|
Write-off of lease liability |
€ 700
|
|
|
|
|
|
|
|
|
|
|
|
|
Lease liabilities – Premises Innate Inc. |
|
|
|
|
|
|
|
|
|
|
|
|
|
Disclosure of financial liabilities [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Financial liabilities |
|
|
|
|
|
|
|
207
|
297
|
246
|
345
|
|
|
Proceeds from borrowing |
|
|
|
|
|
|
|
0
|
0
|
|
|
|
|
Proceeds from lease liabilities and other non cash effects |
|
|
|
|
|
|
|
0
|
0
|
|
|
|
|
Repayments of borrowings/leases liabilities |
|
|
|
|
|
|
|
(47)
|
(50)
|
|
|
|
|
Exchange rate variation (non cash) |
|
|
|
|
|
|
|
8
|
2
|
|
|
|
|
Lease liabilities – Laboratory equipment |
|
|
|
|
|
|
|
|
|
|
|
|
|
Disclosure of financial liabilities [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Financial liabilities |
|
|
|
|
|
|
|
26
|
198
|
109
|
287
|
|
|
Proceeds from borrowing |
|
|
|
|
|
|
|
0
|
0
|
|
|
|
|
Proceeds from lease liabilities and other non cash effects |
|
|
|
|
|
|
|
0
|
0
|
|
|
|
|
Repayments of borrowings/leases liabilities |
|
|
|
|
|
|
|
(83)
|
(89)
|
|
|
|
|
Exchange rate variation (non cash) |
|
|
|
|
|
|
|
0
|
0
|
|
|
|
|
Lease liabilities – Vehicles |
|
|
|
|
|
|
|
|
|
|
|
|
|
Disclosure of financial liabilities [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Financial liabilities |
|
|
|
|
|
|
|
87
|
70
|
85
|
33
|
|
|
Proceeds from borrowing |
|
|
|
|
|
|
|
0
|
0
|
|
|
|
|
Proceeds from lease liabilities and other non cash effects |
|
|
|
|
|
|
|
19
|
48
|
|
|
|
|
Repayments of borrowings/leases liabilities |
|
|
|
|
|
|
|
(17)
|
(13)
|
|
|
|
|
Exchange rate variation (non cash) |
|
|
|
|
|
|
|
0
|
0
|
|
|
|
|
Lease liabilities - Printers |
|
|
|
|
|
|
|
|
|
|
|
|
|
Disclosure of financial liabilities [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Financial liabilities |
|
|
|
|
|
|
|
13
|
23
|
18
|
27
|
|
|
Proceeds from borrowing |
|
|
|
|
|
|
|
0
|
0
|
|
|
|
|
Proceeds from lease liabilities and other non cash effects |
|
|
|
|
|
|
|
0
|
0
|
|
|
|
|
Repayments of borrowings/leases liabilities |
|
|
|
|
|
|
|
(4)
|
(4)
|
|
|
|
|
Exchange rate variation (non cash) |
|
|
|
|
|
|
|
0
|
0
|
|
|
|
|
Borrowing – Equipment |
|
|
|
|
|
|
|
|
|
|
|
|
|
Disclosure of financial liabilities [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Financial liabilities |
|
|
|
|
|
|
|
71
|
127
|
99
|
154
|
|
|
Proceeds from borrowing |
|
|
|
|
|
|
|
0
|
0
|
|
|
|
|
Proceeds from lease liabilities and other non cash effects |
|
|
|
|
|
|
|
0
|
0
|
|
|
|
|
Repayments of borrowings/leases liabilities |
|
|
|
|
|
|
|
(28)
|
(27)
|
|
|
|
|
Exchange rate variation (non cash) |
|
|
|
|
|
|
|
0
|
0
|
|
|
|
|
Borrowing – Building (2) |
|
|
|
|
|
|
|
|
|
|
|
|
|
Disclosure of financial liabilities [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Financial liabilities |
|
|
|
|
|
|
|
9,634
|
10,736
|
€ 10,247
|
€ 11,338
|
|
|
Proceeds from borrowing |
|
|
|
|
|
|
|
0
|
0
|
|
|
|
|
Proceeds from lease liabilities and other non cash effects |
|
|
|
|
|
|
|
17
|
0
|
|
|
|
|
Repayments of borrowings/leases liabilities |
|
|
|
|
|
|
|
(630)
|
(602)
|
|
|
|
|
Exchange rate variation (non cash) |
|
|
|
|
|
|
|
0
|
€ 0
|
|
|
|
|
State guaranteed loan, Societe Generale and BNP Paribas |
|
|
|
|
|
|
|
|
|
|
|
|
|
Disclosure of financial liabilities [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Notional amount |
|
|
€ 28,700
|
|
|
|
|
|
|
|
|
|
|
Borrowing, number of loan agreement | loan_agreement |
|
|
2
|
|
|
|
|
|
|
|
|
|
|
Borrowing, maturity |
|
|
1 year
|
|
|
|
|
|
|
|
|
|
|
Borrowing, maturity, extension period option |
|
|
5 years
|
|
|
|
|
|
|
|
|
|
|
Borrowing, percentage of state-guaranteed loan |
|
|
90.00%
|
|
|
|
|
|
|
|
|
|
|
Loan agreement with Société Générale |
|
|
|
|
|
|
|
|
|
|
|
|
|
Disclosure of financial liabilities [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Financial liabilities |
|
|
|
|
|
|
|
€ 9,617
|
|
|
|
€ 1,300
|
€ 1,300
|
Proceeds from borrowing |
|
|
|
€ 13,900
|
|
|
|
|
|
|
|
|
|
Loan agreement, maximum borrowing capacity |
|
|
|
|
€ 15,200
|
|
|
|
|
|
|
|
|
Loan agreement, collateral |
|
|
|
|
15,200
|
|
|
|
|
|
|
|
|
Borrowings, maturity period |
|
|
|
12 years
|
|
|
|
|
|
|
|
|
|
Security interest on pledge of financial instruments will be released in 2024 |
|
|
|
|
4,200
|
|
|
|
|
|
|
|
|
Security interest on pledge of financial instruments will be released in 2027 |
|
|
|
|
5,000
|
|
|
|
|
|
|
|
|
Security interest on pledge of financial instruments will be released in 2031 |
|
|
|
|
€ 6,000
|
|
|
|
|
|
|
|
|
Loan agreement with Société Générale | Other disposals of assets [member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Disclosure of financial liabilities [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Security interest on pledge of financial instruments released |
|
|
|
|
|
€ 4,200
|
|
|
|
|
|
|
|
Loan agreement with Société Générale | Fixed interest rate |
|
|
|
|
|
|
|
|
|
|
|
|
|
Disclosure of financial liabilities [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Borrowings, interest rate |
|
|
|
|
|
|
|
2.01%
|
|
|
|
|
|
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v3.24.2.u1
Financial liabilities - Disclosure of maturity analysis for non-derivative financial liabilities (Details) € in Thousands |
Jun. 30, 2024
EUR (€)
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
€ 36,869
|
Within 1 year |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
9,414
|
From 2nd to 5th year included |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
24,245
|
Over 5 years |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
3,210
|
State guaranteed loan Société Générale (1) |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
18,086
|
State guaranteed loan Société Générale (1) | Within 1 year |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
5,167
|
State guaranteed loan Société Générale (1) | From 2nd to 5th year included |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
12,918
|
State guaranteed loan Société Générale (1) | Over 5 years |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
0
|
State guaranteed loan BNP Paribas (1) |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
7,773
|
State guaranteed loan BNP Paribas (1) | Within 1 year |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
2,222
|
State guaranteed loan BNP Paribas (1) | From 2nd to 5th year included |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
5,551
|
State guaranteed loan BNP Paribas (1) | Over 5 years |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
0
|
State guaranteed loans - accrued interest |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
0
|
State guaranteed loans - accrued interest | Within 1 year |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
0
|
State guaranteed loans - accrued interest | From 2nd to 5th year included |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
0
|
State guaranteed loans - accrued interest | Over 5 years |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
0
|
Lease liabilities – Building "Le Virage" |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
254
|
Lease liabilities – Building "Le Virage" | Within 1 year |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
254
|
Lease liabilities – Building "Le Virage" | From 2nd to 5th year included |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
0
|
Lease liabilities – Building "Le Virage" | Over 5 years |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
0
|
Lease liabilities – Premises Innate Inc. |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
211
|
Lease liabilities – Premises Innate Inc. | Within 1 year |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
100
|
Lease liabilities – Premises Innate Inc. | From 2nd to 5th year included |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
111
|
Lease liabilities – Premises Innate Inc. | Over 5 years |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
0
|
Lease liabilities – Laboratory equipment |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
26
|
Lease liabilities – Laboratory equipment | Within 1 year |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
26
|
Lease liabilities – Laboratory equipment | From 2nd to 5th year included |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
0
|
Lease liabilities – Laboratory equipment | Over 5 years |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
0
|
Lease liabilities – Vehicles |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
92
|
Lease liabilities – Vehicles | Within 1 year |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
34
|
Lease liabilities – Vehicles | From 2nd to 5th year included |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
59
|
Lease liabilities – Vehicles | Over 5 years |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
0
|
Lease liabilities - Printers |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
13
|
Lease liabilities - Printers | Within 1 year |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
9
|
Lease liabilities - Printers | From 2nd to 5th year included |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
4
|
Lease liabilities - Printers | Over 5 years |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
0
|
Borrowing – Equipment |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
71
|
Borrowing – Equipment | Within 1 year |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
57
|
Borrowing – Equipment | From 2nd to 5th year included |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
14
|
Borrowing – Equipment | Over 5 years |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
0
|
Borrowing – Building (2) |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
10,342
|
Borrowing – Building (2) | Within 1 year |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
1,545
|
Borrowing – Building (2) | From 2nd to 5th year included |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
5,587
|
Borrowing – Building (2) | Over 5 years |
|
Statement Line Items [Line Items] |
|
Undiscounted cash flows |
€ 3,210
|
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v3.24.2.u1
Capital - Additional Information (Details) - EUR (€)
|
6 Months Ended |
|
|
Jun. 30, 2024 |
Jun. 30, 2023 |
Dec. 31, 2023 |
Dec. 31, 2022 |
Disclosure of changes in the share capital |
|
|
|
|
Total shareholders’ equity |
€ 28,796,000
|
€ 57,863,000
|
€ 51,901,000
|
€ 54,151,000
|
Exercise and subscription of equity instruments |
€ 93,000
|
348,000
|
|
|
Number of own shares (in shares) |
18,575
|
|
18,575
|
|
BSAAR 2012 |
|
|
|
|
Disclosure of changes in the share capital |
|
|
|
|
Number of equity instruments converted in ordinary shares (in shares) |
38,100
|
|
|
|
Share issued, price per share (in EUR per share) |
€ 2.45
|
|
|
|
Company saving plan |
|
|
|
|
Disclosure of changes in the share capital |
|
|
|
|
Exercise and subscription of equity instruments (in shares) |
106,844
|
|
|
|
Company saving plan, employer top-up |
|
|
|
|
Disclosure of changes in the share capital |
|
|
|
|
Exercise and subscription of equity instruments (in shares) |
68,744
|
|
|
|
Ordinary Shares |
|
|
|
|
Disclosure of changes in the share capital |
|
|
|
|
Number of shares outstanding (in shares) |
80,967,407
|
|
|
|
Par value per share (in EUR per share) |
€ 0.05
|
|
|
|
The 2016 free preferred shares |
|
|
|
|
Disclosure of changes in the share capital |
|
|
|
|
Par value per share (in EUR per share) |
€ 0.05
|
|
|
|
Total number of shares issued (in shares) |
6,509
|
|
|
|
The 2017 free preferred shares |
|
|
|
|
Disclosure of changes in the share capital |
|
|
|
|
Par value per share (in EUR per share) |
€ 0.05
|
|
|
|
Total number of shares issued (in shares) |
7,581
|
|
|
|
Share capital |
|
|
|
|
Disclosure of changes in the share capital |
|
|
|
|
Total shareholders’ equity |
€ 4,049,075
|
4,027,000
|
€ 4,044,000
|
€ 4,011,000
|
Exercise and subscription of equity instruments |
€ 5,342
|
€ 15,000
|
|
|
Share capital | Ordinary Shares |
|
|
|
|
Disclosure of changes in the share capital |
|
|
|
|
Total number of shares issued (in shares) |
80,967,407
|
80,516,622
|
80,860,563
|
80,212,069
|
Exercise and subscription of equity instruments (in shares) |
106,844
|
304,553
|
|
|
Share premium |
|
|
|
|
Disclosure of changes in the share capital |
|
|
|
|
Total shareholders’ equity |
€ 386,049,000
|
€ 381,371,000
|
€ 384,255,000
|
€ 379,637,000
|
Exercise and subscription of equity instruments |
€ 88,003
|
€ 333,000
|
|
|
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v3.24.2.u1
Capital - Disclosure of number and weighted average exercise prices of other equity instruments (Details)
|
Jun. 30, 2024
shares
€ / shares
|
Jun. 10, 2024
share
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) | share |
|
106,844
|
Warrants |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
12,914,414
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
3,239,985
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
3,340,434
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
6,333,995
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
7,084,922
|
|
BSAAR 2011 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
650,000
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
25,000
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
625,000
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
0
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 2.04
|
|
BSAAR 2012 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
146,050
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
12,250
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
133,800
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
0
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 2.04
|
|
BSAAR 2015 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
1,050,382
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
2,720
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
1,940
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
1,045,722
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
1,045,722
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 7.20
|
|
AGAP Management 2016-1 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
2,000
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
550
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
250
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
1,200
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
156,000
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
AGAP Employees 2016-1 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
2,486
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
251
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
172
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
2,063
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
268,190
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
AGA Management 2016-1 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
50,000
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
50,000
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
0
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
AGAP Management 2016-2 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
3,000
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
3,000
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
333,000
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
AGA Management 2016-2 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
250,000
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
250,000
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
0
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
AGAP Employees 2017-1 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
5,725
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
5,725
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
0
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
AGAP Management 2017-1 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
2,400
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
2,400
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
0
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
AGA Employees 2017 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
114,500
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
4,000
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
110,500
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
0
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
AGA Bonus 2018-1 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
67,028
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
469
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
66,559
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
0
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
AGAP Perf Employees 2018-1 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
327,500
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
224,375
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
103,125
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
0
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
AGAP Perf Management 2018-1 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
260,000
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
150,000
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
110,000
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
0
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
AGA Employees 2018 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
90,650
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
5,000
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
85,650
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
0
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
AGA New Members 2017-1 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
25,000
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
25,000
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
0
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
AGA Bonus 2019-1 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
57,376
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
57,376
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
0
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
AGA Bonus 2020-1 & 2 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
79,861
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
17,885
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
61,976
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
0
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
AGAP Employees 2020-1 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
766,650
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
681,420
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
85,230
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
0
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
AGAP Management 2020-1 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
710,000
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
580,000
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
130,000
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
0
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
AGA Bonus 2021-1 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
125,748
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
125,748
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
0
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
AGAP Employees 2021-1 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
1,066,600
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
290,800
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
775,800
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
775,800
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
AGAP Management 2021-1 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
610,000
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
130,000
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
480,000
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
480,000
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
AGA "Plan Epargne Entreprise" 2022 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
138,960
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
138,960
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
0
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
AGA Bonus 2022-1 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
128,061
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
128,061
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
0
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
AGA Perf Employees 2022-1 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
1,371,500
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
275,000
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
1,096,500
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
1,096,500
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
AGA Perf Management 2022-1 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
550,000
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
550,000
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
550,000
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
AGA "Plan Epargne Entreprise" 2023 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
163,293
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
163,293
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
0
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
AGA New members 2023-1 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
25,000
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
25,000
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
25,000
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
AGA Perf Employees 2023-1 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
1,403,500
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
66,250
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
1,337,250
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
1,337,250
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
AGA Perf Management 2023-1 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
750,000
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
750,000
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
750,000
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
AGA New members 2024-1 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
25,000
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
25,000
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
25,000
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
AGA "Plan Epargne Entreprise" 2024 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
68,744
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
68,744
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
0
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
Stock Options 2020-1 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
102,000
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
102,000
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
0
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
AGAP 2019 Employees 2019 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
546,700
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
375,150
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
171,550
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
0
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
AGAP 2019 Management 2019 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
355,000
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
207,500
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
147,500
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
0
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 0
|
|
BSA 2011-2 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
225,000
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
25,000
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
200,000
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
0
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 1.77
|
|
BSA 2013 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
237,500
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
12,500
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
225,000
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
0
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 2.36
|
|
BSA 2014 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
150,000
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
75,000
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
75,000
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
75,000
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 8.65
|
|
BSA 2015-1 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
70,000
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
70,000
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
70,000
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 9.59
|
|
BSA 2015-2 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
14,200
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
14,200
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
14,200
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 14.05
|
|
BSA 2017 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
37,000
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
37,000
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
37,000
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 11.00
|
|
BSA 2022-1 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
40,000
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
31,740
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
8,260
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
8,260
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 2.31
|
|
BSA 2023-1 |
|
|
Disclosure of terms and conditions of share-based payment arrangement [Line Items] |
|
|
Number of free shares granted (in shares) |
50,000
|
|
Number of other equity instruments forfeited in share-based payment arrangement (in shares) |
12,000
|
|
Number of other equity instruments exercised or vested in share-based payment arrangement (in shares) |
0
|
|
Number of other equity instruments outstanding in share-based payment arrangement (in shares) |
38,000
|
|
Number of other equity instruments exercisable in share-based payment arrangement (in shares) |
38,000
|
|
Weighted average exercise price of other equity instruments outstanding in share-based payment arrangement (in EUR per share) | € / shares |
€ 2.26
|
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v3.24.2.u1
Financial instruments recognized in the statement of financial position and related effect on the income statement - Disclosure of detailed information about financial instruments (Details) - EUR (€) € in Thousands |
Jun. 30, 2024 |
Dec. 31, 2023 |
Disclosure of detailed information about financial instruments [line items] |
|
|
Financial assets |
€ 136,422
|
€ 168,363
|
Financial assets, fair value |
136,422
|
168,363
|
Financial liabilities |
51,376
|
56,911
|
Financial liabilities, fair value |
51,376
|
56,911
|
Financial liabilities at fair value through profit or loss, category |
|
|
Disclosure of detailed information about financial instruments [line items] |
|
|
Financial liabilities |
0
|
0
|
Financial liabilities at amortised cost, category |
|
|
Disclosure of detailed information about financial instruments [line items] |
|
|
Financial liabilities |
51,376
|
56,911
|
Financial liabilities—non-current portion |
|
|
Disclosure of detailed information about financial instruments [line items] |
|
|
Financial liabilities |
26,574
|
30,957
|
Financial liabilities, fair value |
26,574
|
30,957
|
Financial liabilities—non-current portion | Financial liabilities at fair value through profit or loss, category |
|
|
Disclosure of detailed information about financial instruments [line items] |
|
|
Financial liabilities |
0
|
0
|
Financial liabilities—non-current portion | Financial liabilities at amortised cost, category |
|
|
Disclosure of detailed information about financial instruments [line items] |
|
|
Financial liabilities |
26,574
|
30,957
|
Financial liabilities—current portion |
|
|
Disclosure of detailed information about financial instruments [line items] |
|
|
Financial liabilities |
8,929
|
8,936
|
Financial liabilities, fair value |
8,929
|
8,936
|
Financial liabilities—current portion | Financial liabilities at fair value through profit or loss, category |
|
|
Disclosure of detailed information about financial instruments [line items] |
|
|
Financial liabilities |
0
|
0
|
Financial liabilities—current portion | Financial liabilities at amortised cost, category |
|
|
Disclosure of detailed information about financial instruments [line items] |
|
|
Financial liabilities |
8,929
|
8,936
|
Trade payables and others |
|
|
Disclosure of detailed information about financial instruments [line items] |
|
|
Financial liabilities |
15,873
|
17,018
|
Financial liabilities, fair value |
15,873
|
17,018
|
Trade payables and others | Financial liabilities at fair value through profit or loss, category |
|
|
Disclosure of detailed information about financial instruments [line items] |
|
|
Financial liabilities |
0
|
0
|
Trade payables and others | Financial liabilities at amortised cost, category |
|
|
Disclosure of detailed information about financial instruments [line items] |
|
|
Financial liabilities |
15,873
|
17,018
|
Financial assets at fair value through profit or loss, category |
|
|
Disclosure of detailed information about financial instruments [line items] |
|
|
Financial assets |
102,149
|
102,252
|
Financial assets at amortised cost, category |
|
|
Disclosure of detailed information about financial instruments [line items] |
|
|
Financial assets |
34,273
|
66,111
|
Non-current financial assets |
|
|
Disclosure of detailed information about financial instruments [line items] |
|
|
Financial assets |
10,350
|
9,796
|
Financial assets, fair value |
10,350
|
9,796
|
Non-current financial assets | Financial assets at fair value through profit or loss, category |
|
|
Disclosure of detailed information about financial instruments [line items] |
|
|
Financial assets |
10,350
|
9,796
|
Non-current financial assets | Financial assets at amortised cost, category |
|
|
Disclosure of detailed information about financial instruments [line items] |
|
|
Financial assets |
0
|
0
|
Trade receivables and others |
|
|
Disclosure of detailed information about financial instruments [line items] |
|
|
Financial assets |
34,273
|
66,111
|
Financial assets, fair value |
34,273
|
66,111
|
Trade receivables and others | Financial assets at fair value through profit or loss, category |
|
|
Disclosure of detailed information about financial instruments [line items] |
|
|
Financial assets |
0
|
0
|
Trade receivables and others | Financial assets at amortised cost, category |
|
|
Disclosure of detailed information about financial instruments [line items] |
|
|
Financial assets |
34,273
|
66,111
|
Short-term investments |
|
|
Disclosure of detailed information about financial instruments [line items] |
|
|
Financial assets |
21,809
|
21,851
|
Financial assets, fair value |
21,809
|
21,851
|
Short-term investments | Financial assets at fair value through profit or loss, category |
|
|
Disclosure of detailed information about financial instruments [line items] |
|
|
Financial assets |
21,809
|
21,851
|
Short-term investments | Financial assets at amortised cost, category |
|
|
Disclosure of detailed information about financial instruments [line items] |
|
|
Financial assets |
0
|
0
|
Cash and cash equivalents |
|
|
Disclosure of detailed information about financial instruments [line items] |
|
|
Financial assets |
69,990
|
70,605
|
Financial assets, fair value |
69,990
|
70,605
|
Cash and cash equivalents | Financial assets at fair value through profit or loss, category |
|
|
Disclosure of detailed information about financial instruments [line items] |
|
|
Financial assets |
69,990
|
70,605
|
Cash and cash equivalents | Financial assets at amortised cost, category |
|
|
Disclosure of detailed information about financial instruments [line items] |
|
|
Financial assets |
€ 0
|
€ 0
|
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6 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
Disclosure of disaggregation of revenue from contracts with customers [line items] |
|
|
Revenue from collaboration and licensing agreements |
€ 8,293
|
€ 35,344
|
Proceeds from collaboration and licensing agreements |
|
|
Disclosure of disaggregation of revenue from contracts with customers [line items] |
|
|
Revenue from collaboration and licensing agreements |
7,396
|
34,728
|
Monalizumab agreement (AstraZeneca) |
|
|
Disclosure of disaggregation of revenue from contracts with customers [line items] |
|
|
Revenue from collaboration and licensing agreements |
2,994
|
9,503
|
Agreement with Sanofi, 2016 |
|
|
Disclosure of disaggregation of revenue from contracts with customers [line items] |
|
|
Revenue from collaboration and licensing agreements |
4,000
|
2,000
|
Agreement with Sanofi, 2022 - ANKET IPH62 |
|
|
Disclosure of disaggregation of revenue from contracts with customers [line items] |
|
|
Revenue from collaboration and licensing agreements |
199
|
18,672
|
Agreement With Sanofi 2022 - ANKET IPH67 |
|
|
Disclosure of disaggregation of revenue from contracts with customers [line items] |
|
|
Revenue from collaboration and licensing agreements |
203
|
0
|
Takeda agreement |
|
|
Disclosure of disaggregation of revenue from contracts with customers [line items] |
|
|
Revenue from collaboration and licensing agreements |
0
|
4,553
|
Invoicing of R&D costs (IPH5201 agreement) |
|
|
Disclosure of disaggregation of revenue from contracts with customers [line items] |
|
|
Revenue from collaboration and licensing agreements |
€ 897
|
€ 616
|
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1 Months Ended |
6 Months Ended |
Mar. 31, 2023
EUR (€)
target_option
|
Jun. 30, 2024
EUR (€)
preclinicalMolecule
|
Jun. 30, 2023
EUR (€)
|
Agreement with Sanofi, 2022 |
|
|
|
Collaboration Liabilities, Roll Forward [Abstract] |
|
|
|
Payments for target options |
€ 5,000
|
|
|
Number of target options | target_option |
2
|
|
|
Payments for research work |
€ 1,500
|
|
|
Agreements with Sanofi for NK Cell engages |
|
|
|
Collaboration Liabilities, Roll Forward [Abstract] |
|
|
|
Payments for target options |
|
€ 5,000
|
|
Number of target options | target_option |
2
|
|
|
Number of preclinical molecules | preclinicalMolecule |
|
2
|
|
Revenues from contract liabilities, period |
|
3 years
|
|
Payments for research work |
€ 1,700
|
€ 1,500
|
|
Deferred revenue |
|
|
|
Deferred Revenue, Roll Forward [Abstract] |
|
|
|
Contract liabilities at beginning of period |
|
10,481
|
€ 14,481
|
Revenue for the six months period/Deductions |
|
(3,396)
|
(9,675)
|
Contract liabilities at end of period |
|
6,915
|
11,024
|
Collaboration Liabilities, Roll Forward [Abstract] |
|
|
|
Contract liabilities at beginning of period |
|
10,481
|
14,481
|
Contract liabilities at end of period |
|
6,915
|
11,024
|
Deferred revenue | 2015 monalizumab agreement, with AstraZeneca |
|
|
|
Deferred Revenue, Roll Forward [Abstract] |
|
|
|
Contract liabilities at beginning of period |
|
5,156
|
14,481
|
Revenue for the six months period/Deductions |
|
(2,994)
|
(9,503)
|
Transfer from / (to) collaboration liabilities |
|
(172)
|
(283)
|
Contract liabilities at end of period |
|
1,990
|
4,695
|
Collaboration Liabilities, Roll Forward [Abstract] |
|
|
|
Contract liabilities at beginning of period |
|
5,156
|
14,481
|
Contract liabilities at end of period |
|
1,990
|
4,695
|
Deferred revenue | Agreement with Sanofi, 2022 |
|
|
|
Deferred Revenue, Roll Forward [Abstract] |
|
|
|
Contract liabilities at beginning of period |
|
5,327
|
0
|
Increase in deferred revenue/Additions |
|
0
|
6,500
|
Revenue for the six months period/Deductions |
|
(402)
|
(172)
|
Contract liabilities at end of period |
|
4,925
|
6,328
|
Collaboration Liabilities, Roll Forward [Abstract] |
|
|
|
Contract liabilities at beginning of period |
|
5,327
|
0
|
Contract liabilities at end of period |
|
4,925
|
6,328
|
Collaboration liabilities | 2015 monalizumab agreement, with AstraZeneca |
|
|
|
Deferred Revenue, Roll Forward [Abstract] |
|
|
|
Contract liabilities at beginning of period |
|
52,677
|
63,211
|
Contract liabilities at end of period |
|
52,149
|
56,058
|
Collaboration Liabilities, Roll Forward [Abstract] |
|
|
|
Contract liabilities at beginning of period |
|
52,677
|
63,211
|
Additions |
|
1,891
|
283
|
Deductions |
|
(2,419)
|
(7,436)
|
Contract liabilities at end of period |
|
€ 52,149
|
€ 56,058
|
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|
|
1 Months Ended |
6 Months Ended |
Dec. 19, 2023
option
|
Jan. 25, 2023
EUR (€)
|
Mar. 31, 2023
EUR (€)
target_option
|
Jun. 30, 2024
EUR (€)
|
Jun. 30, 2023
EUR (€)
|
Disclosure of disaggregation of revenue from contracts with customers [line items] |
|
|
|
|
|
Revenue from collaboration and licensing agreements |
|
|
|
€ 8,293
|
€ 35,344
|
IPH5201 agreement, with AstraZeneca |
|
|
|
|
|
Disclosure of disaggregation of revenue from contracts with customers [line items] |
|
|
|
|
|
Revenue from collaboration and licensing agreements |
|
|
|
0
|
0
|
External costs related to the clinical trial |
|
|
|
897
|
616
|
Agreement with Sanofi, 2016 |
|
|
|
|
|
Disclosure of disaggregation of revenue from contracts with customers [line items] |
|
|
|
|
|
Revenue from collaboration and licensing agreements |
|
|
|
4,000
|
2,000
|
Milestone payment received |
|
|
|
4,000
|
€ 2,000
|
Agreement with Sanofi, 2022 |
|
|
|
|
|
Disclosure of disaggregation of revenue from contracts with customers [line items] |
|
|
|
|
|
Advance received |
|
|
€ 25,000
|
|
|
Advance received - exclusive license |
|
|
18,500
|
|
|
Payments for research work |
|
|
1,500
|
|
|
Payments for target options |
|
|
€ 5,000
|
|
|
Number of target options | target_option |
|
|
2
|
|
|
Agreements with Sanofi for NK Cell engages |
|
|
|
|
|
Disclosure of disaggregation of revenue from contracts with customers [line items] |
|
|
|
|
|
Advance received |
|
€ 31,800
|
|
|
|
Advance received - exclusive license |
|
18,500
|
€ 13,300
|
|
|
Payments for research work |
|
|
€ 1,700
|
1,500
|
|
Payments for target options |
|
|
|
€ 5,000
|
|
Number of target options | target_option |
|
|
2
|
|
|
Number of options excercised for licenses | option |
1
|
|
|
|
|
Number of exclusive options granted | option |
2
|
|
|
|
|
Milestone payment received - option exercised |
|
€ 13,300
|
|
|
|
Agreement with Sanofi, 2022 |
|
|
|
|
|
Disclosure of disaggregation of revenue from contracts with customers [line items] |
|
|
|
|
|
Milestone payment received - option exercised |
|
|
€ 15,000
|
|
|
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6 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
Disclosure of disaggregation of revenue from contracts with customers [line items] |
|
|
Contract liabilities at beginning of period |
€ 10,481
|
€ 14,481
|
Recognition in P&L |
(3,396)
|
(9,675)
|
Proceeds |
0
|
5,000
|
Transfer from / (to) collaboration liabilities |
(172)
|
(283)
|
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6,915
|
11,024
|
Monalizumab |
|
|
Disclosure of disaggregation of revenue from contracts with customers [line items] |
|
|
Contract liabilities at beginning of period |
5,155
|
14,481
|
Recognition in P&L |
(2,994)
|
(9,503)
|
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0
|
0
|
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(172)
|
(283)
|
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1,990
|
4,696
|
Sanofi (2022) option |
|
|
Disclosure of disaggregation of revenue from contracts with customers [line items] |
|
|
Contract liabilities at beginning of period |
2,500
|
0
|
Recognition in P&L |
0
|
0
|
Proceeds |
0
|
5,000
|
Transfer from / (to) collaboration liabilities |
0
|
0
|
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2,500
|
5,000
|
Sanofi (2022) services |
|
|
Disclosure of disaggregation of revenue from contracts with customers [line items] |
|
|
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2,826
|
0
|
Recognition in P&L |
(402)
|
(172)
|
Proceeds |
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|
1,500
|
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|
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€ 1,328
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Operating expenses - Disclosure of expenses by nature (Details) - EUR (€) € in Thousands |
6 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
Statement Line Items [Line Items] |
|
|
Subcontracting costs |
€ (15,585)
|
€ (15,857)
|
Cost of supplies and consumable materials |
(1,638)
|
(1,510)
|
Personnel expenses other than share-based compensation |
(11,002)
|
(11,652)
|
Share-based compensation |
(1,706)
|
(1,401)
|
Personnel expenses |
(12,708)
|
(13,053)
|
Non-scientific advisory and consulting |
(2,058)
|
(2,194)
|
Leasing and maintenance |
(1,200)
|
(915)
|
Travel expenses and meeting attendance |
(423)
|
(323)
|
Marketing, communication and public relations |
(180)
|
(176)
|
Scientific advisory and consulting |
(933)
|
(561)
|
Other purchases and external expenses |
(1,135)
|
(1,166)
|
Depreciation and amortization |
(1,146)
|
(3,645)
|
Intellectual property expenses |
(696)
|
(638)
|
Other income and (expenses), net |
(956)
|
(562)
|
Operating expenses |
(38,657)
|
(40,597)
|
R&D |
|
|
Statement Line Items [Line Items] |
|
|
Subcontracting costs |
(15,585)
|
(15,857)
|
Cost of supplies and consumable materials |
(1,485)
|
(1,410)
|
Personnel expenses other than share-based compensation |
(7,532)
|
(7,781)
|
Share-based compensation |
(1,175)
|
(905)
|
Personnel expenses |
(8,707)
|
(8,686)
|
Non-scientific advisory and consulting |
(124)
|
(532)
|
Leasing and maintenance |
(490)
|
(470)
|
Travel expenses and meeting attendance |
(272)
|
(180)
|
Marketing, communication and public relations |
(16)
|
(34)
|
Scientific advisory and consulting |
(933)
|
(561)
|
Other purchases and external expenses |
(10)
|
(13)
|
Depreciation and amortization |
(643)
|
(3,044)
|
Intellectual property expenses |
(568)
|
(570)
|
Other income and (expenses), net |
(242)
|
(98)
|
Operating expenses |
(29,076)
|
(31,453)
|
G&A |
|
|
Statement Line Items [Line Items] |
|
|
Subcontracting costs |
0
|
0
|
Cost of supplies and consumable materials |
(153)
|
(100)
|
Personnel expenses other than share-based compensation |
(3,470)
|
(3,871)
|
Share-based compensation |
(531)
|
(496)
|
Personnel expenses |
(4,001)
|
(4,367)
|
Non-scientific advisory and consulting |
(1,934)
|
(1,662)
|
Leasing and maintenance |
(710)
|
(445)
|
Travel expenses and meeting attendance |
(151)
|
(143)
|
Marketing, communication and public relations |
(164)
|
(142)
|
Scientific advisory and consulting |
0
|
0
|
Other purchases and external expenses |
(1,125)
|
(1,153)
|
Depreciation and amortization |
(503)
|
(601)
|
Intellectual property expenses |
(128)
|
(68)
|
Other income and (expenses), net |
(714)
|
(464)
|
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€ (9,582)
|
€ (9,144)
|
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6 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
Analysis of income and expense [abstract] |
|
|
Interests on financial assets |
€ 1,269
|
€ 965
|
Change in valuation allowance on financial instruments |
1,471
|
1,044
|
Foreign exchange gains |
873
|
1,073
|
Financial income |
3,613
|
3,083
|
Foreign exchange losses |
(1,763)
|
(642)
|
Unrealized losses on financial assets |
0
|
0
|
Interest on financial liabilities |
(300)
|
(324)
|
Financial expenses |
(2,064)
|
(966)
|
Net financial income (loss) |
€ 1,549
|
€ 2,116
|
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6 Months Ended |
|
|
Dec. 31, 2024 |
Jun. 30, 2024
EUR (€)
|
Jun. 30, 2024
USD ($)
|
Dec. 31, 2023
EUR (€)
|
Dec. 31, 2023
USD ($)
|
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|
|
|
|
|
Current tax expense (income) |
|
€ 0
|
|
|
|
Unused tax losses with no expiration date |
|
483,570
|
|
€ 483,570
|
|
Unused tax losses subject to expiration |
|
€ 15,181
|
$ 16,775
|
€ 15,181
|
$ 16,775
|
Forecast |
|
|
|
|
|
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|
|
|
|
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|
1 Months Ended |
6 Months Ended |
|
Jul. 03, 2017 |
Jul. 31, 2024 |
Jun. 30, 2024 |
Dec. 31, 2023 |
Disclosure of contingent liabilities [table] |
|
|
|
|
Non-cancellable off-balance sheet purchase commitments |
|
|
€ 6,612
|
|
Total provisions |
|
|
669
|
€ 774
|
Tax and employee-related payables |
|
|
6,013
|
7,021
|
Payment of short term tax liability |
|
|
693
|
|
Tax contingent liability |
|
|
|
|
Disclosure of contingent liabilities [table] |
|
|
|
|
Tax and employee-related payables |
|
|
|
€ 1,367
|
Grants of employee equity instruments |
|
|
|
|
Disclosure of contingent liabilities [table] |
|
|
|
|
Total provisions |
|
|
586
|
|
Loan agreement with Société Générale |
|
|
|
|
Disclosure of contingent liabilities [table] |
|
|
|
|
Security interest on pledge of financial instruments will be released in 2024 |
€ 4,200
|
|
|
|
Security interest on pledge of financial instruments will be released in 2027 |
5,000
|
|
|
|
Security interest on pledge of financial instruments will be released in 2031 |
€ 6,000
|
|
|
|
Loan agreement with Société Générale | Changes to commitments |
|
|
|
|
Disclosure of contingent liabilities [table] |
|
|
|
|
Security interest on pledge of financial instruments released in 2024 including interest |
|
€ 4,427
|
|
|
Preclinical Services |
|
|
|
|
Disclosure of contingent liabilities [table] |
|
|
|
|
Non-cancellable off-balance sheet purchase commitments |
|
|
3,020
|
|
Clinical Services |
|
|
|
|
Disclosure of contingent liabilities [table] |
|
|
|
|
Non-cancellable off-balance sheet purchase commitments |
|
|
€ 3,592
|
|
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v3.24.2.u1
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- DefinitionThe amount of provision for attendance fees.
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v3.24.2.u1
v3.24.2.u1
Income / (loss) per share - Summary of income (loss) per share (Details) - EUR (€) € / shares in Units, € in Thousands |
6 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
Income (Loss) Per Share [Abstract] |
|
|
Net income (loss) |
€ (24,764)
|
€ 1,718
|
Weighted average number of ordinary shares in circulation (in shares) |
80,872,369
|
80,319,897
|
Basic income (loss) per share (in EUR per share) |
€ (0.31)
|
€ 0.02
|
Adjustment for share instruments (in shares) |
5,026,389
|
3,461,439
|
Diluted income/(loss) per share (in EUR per share) |
€ (0.31)
|
€ 0.02
|
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v3.24.2.u1
Label |
Element |
Value |
Trade and other payables |
ifrs-full_TradeAndOtherPayables |
€ 17,018,000
|
Trade and other payables |
ifrs-full_TradeAndOtherPayables |
20,911,000
|
Collaboration Liabilities |
inpha_CollaborationLiabilities |
52,677,000
|
Collaboration Liabilities |
inpha_CollaborationLiabilities |
63,211,000
|
Trade and other receivables |
ifrs-full_TradeAndOtherReceivables |
66,111,000
|
Trade and other receivables |
ifrs-full_TradeAndOtherReceivables |
52,445,000
|
Change In Working Capital |
inpha_ChangeInWorkingCapital |
14,067,000
|
Change In Working Capital |
inpha_ChangeInWorkingCapital |
46,158,000
|
Deferred income including contract liabilities |
ifrs-full_DeferredIncomeIncludingContractLiabilities |
10,483,000
|
Deferred income including contract liabilities |
ifrs-full_DeferredIncomeIncludingContractLiabilities |
€ 14,481,000
|
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