Filed Pursuant to Rule 424(b)(5)
Registration No. 333-280757
PROSPECTUS SUPPLEMENT
(To Prospectus Dated August 6, 2024)
Up to $35,000,000 of Shares of Common Stock
This prospectus supplement relates to the issuance
and sale of up to $35,000,000 of shares of our common stock that we may issue and sell to Seven Knots, LLC (“Seven Knots”)
from time to time, in our sole discretion, under a common stock purchase agreement that we entered into with Seven Knots on May 2, 2024
(the “Purchase Agreement”). This prospectus supplement and the accompanying prospectus also cover the resale of these shares
by Seven Knots to the public. See “Seven Knots Transaction” for a description of the Purchase Agreement and additional information
regarding Seven Knots. Seven Knots is an “underwriter” within the meaning of Section 2(a)(11) of the Securities Act of 1933,
as amended (the “Securities Act”).
The purchase price for the shares will be based
on formulas set forth in the Purchase Agreement depending upon the type of purchase notice that we submit to Seven Knots from time to
time. We will pay the expenses incurred in connection with the issuance of the shares of our common stock. See “Plan of Distribution.”
On September 6, 2024, we filed a registration
statement on Form S-3, and an amendment to such registration statement on Form S-1 on September 11, 2024, which was declared effective
by the SEC on September 13, 2024 (SEC File No. 333-281988) that covered the resale of up to 3,750,000 shares of our common stock under
the Purchase Agreement. As of October 4, 2024, we have issued 3,347,535 shares of our common stock for total gross cash proceeds of $6,903,379
pursuant to the Purchase Agreement.
Our common stock is traded on The Nasdaq Capital
Market under the symbol “ADTX.” On October 4, 2024, the last sale price of our common stock as reported on The Nasdaq Capital
Market was $1.60 per share.
Investing in our securities involves a high
degree of risk. You should read the “Risk Factors” section beginning on page S-22 of this prospectus supplement
and page 19 of the accompanying prospectus and in the documents incorporated by reference in this prospectus supplement for a discussion
of factors to consider before deciding to invest in our common stock.
Neither the Securities and Exchange Commission
nor any state securities commission has approved or disapproved of these securities or determined if this prospectus supplement or the
accompanying prospectus is truthful or complete. Any representation to the contrary is a criminal offense.
The date of this prospectus supplement is October
7, 2024
TABLE OF CONTENTS
PROSPECTUS SUPPLEMENT
PROSPECTUS
TABLE OF CONTENTS
ABOUT THIS PROSPECTUS SUPPLEMENT
This prospectus supplement and the accompanying
prospectus are part of a registration statement that we filed with the U.S. Securities and Exchange Commission utilizing a “shelf”
registration process. This document is in two parts. The first part is this prospectus supplement, which describes the specific terms
of this offering and also adds to and updates information contained in the accompanying prospectus and the documents incorporated by
reference herein. The second part, the accompanying prospectus, provides more general information. Generally, when we refer to this prospectus,
we are referring to both parts of this document combined. To the extent there is a conflict between the information contained in this
prospectus supplement and the information contained in the accompanying prospectus or any document incorporated by reference therein
filed prior to the date of this prospectus supplement, you should rely on the information in this prospectus supplement; provided that
if any statement in one of these documents is inconsistent with a statement in another document having a later date—for example,
a document incorporated by reference in the accompanying prospectus—the statement in the document having the later date modifies
or supersedes the earlier statement.
We further note that the representations, warranties
and covenants made by us in any agreement that is filed as an exhibit to any document that is incorporated by reference herein were made
solely for the benefit of the parties to such agreement, including, in some cases, for the purpose of allocating risk among the parties
to such agreements, and should not be deemed to be a representation, warranty or covenant to you. Moreover, such representations, warranties
or covenants were accurate only as of the date when made. Accordingly, such representations, warranties and covenants should not be relied
on as accurately representing the current state of our affairs.
Neither we nor Seven Knots have authorized anyone
to provide you with any information or to make any representations other than those included or incorporated by reference in this prospectus
supplement and the accompanying prospectus and any relevant free writing prospectus we may authorize for use in connection with this
offering. If you receive any information not authorized by us, we take no responsibility for, and can provide no assurance as to the
reliability of, such information. We are not making an offer to sell the securities offered hereby in any jurisdiction where the offer
or sale is not permitted. You should not assume that the information contained or incorporated by reference in this prospectus supplement
or the accompanying prospectus or any relevant free writing prospectus we may authorize for use in connection with this offering is accurate
as of any date other than its respective date, regardless of its time of delivery or any sale of the securities covered hereby. Our business,
financial condition, results of operations and prospects may have changed since that date.
You should rely only on the information contained
in this prospectus supplement or the accompanying prospectus, or incorporated by reference herein. We have not authorized anyone to provide
you with information that is different. The information contained in this prospectus supplement or the accompanying prospectus, or incorporated
by reference herein or therein is accurate only as of the respective dates thereof, regardless of the time of delivery of this prospectus
supplement and the accompanying prospectus or of any sale of our securities. It is important for you to read and consider all information
contained in this prospectus supplement and the accompanying prospectus, including the documents incorporated by reference herein and
therein, in making your investment decision. You should also read and consider the information in the documents to which we have referred
you in the sections entitled “Where You Can Find More Information” and “Incorporation of Documents By Reference”
in this prospectus supplement and in the accompanying prospectus, respectively.
We are offering to sell, and seeking offers to
buy, the securities offered by this prospectus supplement only in jurisdictions where offers and sales are permitted. The distribution
of this prospectus supplement and the accompanying prospectus and the offering of the securities offered by this prospectus supplement
in certain jurisdictions may be restricted by law. Persons outside the United States who come into possession of this prospectus supplement
and the accompanying prospectus must inform themselves about, and observe any restrictions relating to, the offering of the securities
and the distribution of this prospectus supplement and the accompanying prospectus outside the United States. This prospectus supplement
and the accompanying prospectus do not constitute, and may not be used in connection with, an offer to sell, or a solicitation of an
offer to buy, any securities offered by this prospectus supplement and the accompanying prospectus by any person in any jurisdiction
in which it is unlawful for such person to make such an offer or solicitation.
All references in this prospectus supplement
and the accompanying prospectus to “Aditxt,” the “Company,” “we,” “us,” “our,”
or similar terms refer to Aditxt, Inc. and its subsidiaries taken as a whole, except where the context otherwise requires or as otherwise
indicated.
PROSPECTUS SUPPLEMENT SUMMARY
This summary highlights selected information
about us, this offering and information appearing elsewhere in this prospectus supplement, in the accompanying prospectus and in the
documents incorporated by reference herein and therein. This summary is not complete and does not contain all the information you should
consider before investing in our securities pursuant to this prospectus supplement and the accompanying prospectus. Before making an
investment decision, to fully understand this offering and its consequences to you, you should carefully read this entire prospectus
supplement and the accompanying prospectus, including “Risk Factors,” the financial statements, and related notes, and the
other information incorporated by reference herein and therein.
Overview and Mission
We believe the world needs—and deserves—a
new approach to innovating that harnesses the power of large groups of stakeholders who work together to ensure that the most promising
innovations make it into the hands of people who need them most.
We were incorporated in the State of Delaware
on September 28, 2017, and our headquarters are in Mountain View, California. The company was founded with a mission of bringing stakeholders
together, to transform promising innovations into products and services that could address some of the most challenging needs. The socialization
of innovation through engaging stakeholders in every aspect of it, is key to transforming more innovations, more rapidly, and more efficiently.
At inception, the first innovation we took on
was an immune modulation technology titled ADI/Adimune with a focus on prolonging life and enhancing life quality of patients that have
undergone organ transplants. Since then, we expanded our portfolio of innovations, and we continue to evaluate a variety of promising
health innovations.
Our Model
We are not focused on a single idea or a single
molecule. We believe that it is about making sure the right innovation is made possible. Our business model has three main components
as follows:
|
(1) |
Securing an Innovation:
Our process begins with identifying and securing innovations through licensing or acquisition of an innovation asset. Assets come
from a variety of sources including research institutions, government agencies, and private organizations. |
|
(2) |
Growing an Innovation:
Once an innovation is secured, we surround it with activation resources that take a systemized approach to bringing that idea to
life. Our activation resources include innovation, operations, commercialization, finance, content and engagement, personnel, and
administration. |
|
(3) |
Monetizing an Innovation:
Our goal is for each innovation to become commercial-stage and financially and operationally self-sustainable, to create shareholder
value. |
We engage various stakeholders for each of our
programs on every level. This includes identifying researchers and research institution partners, such as Stanford University; leading
health institutions to get critical trials underway, such as Mayo Clinic; manufacturing partners who enable us to take innovations from
preclinical to clinical; municipalities and governments, such as the city of Richmond and the state of Virginia and public health agencies
who work with us to launch our program, Pearsanta’s laboratory; and thousands of shareholders around the globe. We seek to enable
promising innovation to become purposeful products that have the power to change lives.
Our Value Proposition
We believe that far too often, promising treatment
or technology does not reach commercialization due to lack of expertise, key resources, or efficiency. As a result, potentially life-changing
and lifesaving treatments are not available to the individuals who so desperately need them.
We seek to bring the holistic concept of an efficient,
socialized ecosystem for advancing and accelerating innovations. Our process: We seek to license or acquire promising innovations. We
will then form and build out a subsidiary around each innovation and support the subsidiaries through innovation, operation, commercialization,
content and engagement, finance, personnel, and administration to thrive and grow as a successful, monetizable business.
Since our inception, we have built infrastructure
consisting of innovation, operation, commercialization, content and engagement, finance, personnel, and administration, to support the
rapid transformation of untapped innovations. Each of the main components of our infrastructure has established global access to partnerships
with industry leaders, top-rated research and medical institutions, universities, manufacturing and distribution companies, and critical
infrastructure such as Clinical Laboratory Improvement Amendments-certified state-of-the art labs and Good Manufacturing Practices manufacturing.
The Shifting Landscape of Innovation
Innovation in general,
and health innovations specifically, require significant resources. The convergence of biotech, high-tech, and media offers new possibilities
for accelerating breakthrough innovations faster and more efficiently. This approach reflects our mission of “Making Promising
Innovations Possible, Together”.
People deserve access to innovative solutions
that have never been more within reach. We believe the best idea, best product and the best solution will come from creating an ecosystem
where all stakeholders, such as vendors, customers, municipalities, and shareholders contribute. When we disrupt the way we’re
innovating, through our collaborative model, we believe we can move faster and more efficiently to activate viable solutions that have
the potential to make a measurable impact.
Our Growth Strategy
We believe that the era of precision and personalized
medicine is here and that people around the globe would benefit from health diagnostics and treatments that more accurately pinpoint
the problems and more precisely treat the condition. In addition to our current programs, Adimune and Pearsanta, we look to bring in
future health innovations in the areas of software and AI, medical devices, therapeutics, and other technologies that take a fundamentally
different approach to health because they prioritize personalized precision medicine, timely disease root cause analysis, and targeted
treatments.
Year over year, we plan to continue building
our infrastructure and securing more personalized and precision health innovations that align with our mission. These opportunities may
come in different forms such as intellectual property, an early-stage company, or a late-stage company. We will continue to scale our
systemized approach to the innovation process, making large-scale automation and enterprise systems available to our portfolio companies
at every stage of their growth. Specifically, certain subsidiaries will need to grow through further M&A activities, operational
infrastructure implementation, and development or acquisition of critical technologies.
Our Team
Aditxt is led by an entrepreneurial team with
passion for transforming promising innovations into successful businesses. Our leadership come from a variety of different industries,
with collective expertise in founding startup innovation companies, developing and marketing biopharmaceutical and diagnostic products,
designing clinical trials, manufacturing, and management of private and public companies. We have deep experience in identifying and
accessing promising health innovations and developing them into products and services with the ability to scale. We understand the capital
markets, both public and private, as well as M&A and facilitating complex IPOs.
The following are profiles of three subsidiaries
we have formed, including the terms of the intellectual property licenses that have been sublicensed from Aditxt to help build each of
the businesses.
OUR PROGRAMS
We are a commercial-stage company with a mission
of bringing stakeholders together, to transform promising innovations into products and services that could address some of the most
challenging needs. Our current focus spans five critical areas: immune health, precision health, population health, women’s
health, and neurologic health. We are developing a robust portfolio and pipeline of products at various stages of development and also
regularly seek to acquire complementary assets and products through acquisitions and other strategic transactions. Set forth below is
a summary of our current programs.
Program | |
Focus | |
Product | |
Indication | |
Development | |
Pre-Launch | |
Commercial |
Adimune | |
Immune Health | |
ADI-100 | |
Psoriasis | |
X | |
| |
|
Adimune | |
Immune Health | |
ADI-100 | |
Type 1 diabetes | |
X | |
| |
|
Adimune | |
Immune Health | |
ADI-100 | |
Stiff-persons syndrome | |
X | |
| |
|
Adimune | |
Immune Health | |
ADI-100 | |
Skin allografting | |
X | |
| |
|
Pearsanta | |
Precision Health | |
AditxtScore Ab | |
COVID-19 | |
X | |
X | |
X |
Pearsanta | |
Precision Health | |
AditxtScore NAb | |
COVID-19 | |
X | |
X | |
X |
Pearsanta | |
Precision Health | |
MET | |
Endometriosis | |
X | |
X | |
|
Pearsanta | |
Precision Health | |
MPT | |
Prostate CA | |
X | |
X | |
|
Pearsanta | |
Precision Health | |
UTI | |
Advanced UTI | |
X | |
| |
|
Pearsanta | |
Precision Health | |
MOT | |
Ovarian CA | |
X | |
| |
|
Pearsanta | |
Precision Health | |
PLT | |
Lung CA | |
X | |
| |
|
Pearsanta | |
Precision Health | |
LFA-RVP | |
Flu A/B, COVID | |
X | |
| |
|
Pearsanta | |
Precision Health | |
AditxtScore T1D | |
Type 1 diabetes | |
X | |
| |
|
Pearsanta | |
Precision Health | |
AditxtScore CNS | |
NMO & MOGAD | |
X | |
| |
|
Brain Scientific | |
Neuro Health | |
NeuroCap/NeuroEEG | |
Epilepsy/TBI/Dementia | |
X | |
X | |
|
ADIMUNE
Adimune™, Inc. (“Adimune”)
is focused on leading our immune modulation therapeutic programs. Adimune’s proprietary immune modulation product Apoptotic DNA
Immunotherapy™, or ADI-100™, utilizes a novel approach that mimics how our bodies naturally induce tolerance to our own tissues.
It includes two DNA molecules designed to deliver signals to induce tolerance. ADI-100 has been successfully tested in several preclinical
models (e.g., skin grafting, psoriasis, type 1 diabetes, multiple sclerosis).
In May 2023, Adimune entered into a clinical
trial agreement with Mayo Clinic to advance clinical studies targeting autoimmune diseases of the central nervous system (“CNS”)
with the initial focus on the rare, but debilitating, autoimmune disease Stiff Person Syndrome (“SPS”). According to the
National Organization of Rare Diseases, the exact incidence and prevalence of SPS is unknown; however, one estimate places the incidence
at approximately one in one million individuals in the general population.
Pending approval by the International Review
Board, a human trial for SPS is expected to commence in the first half of 2024 with enrollment of 10 to 15 patients, some of whom may
also have type 1 diabetes. ADI-100™ will initially be tested for safety and efficacy. ADI-100™ is designed to
tolerize against an antigen known as glutamic acid decarboxylase (“GAD”), which is implicated in type-1 diabetes, psoriasis,
and many autoimmune diseases of the CNS.
Background
The discovery of immunosuppressive
(anti-rejection and monoclonal) drugs over 40 years ago enabled life-saving organ transplantation procedures and blocking of unwanted
immune responses in autoimmune diseases. However, immune suppression leads to significant undesirable side effects, such as increased
susceptibility to life-threatening infections and cancers, because it indiscriminately and broadly suppresses immune function throughout
the body. While the use of these drugs has been justifiable because they prevent or delay organ rejection, their use for treatment of
autoimmune diseases and allergies may not be acceptable because of the aforementioned side effects. Furthermore, often transplanted organs
ultimately fail despite the use of immune suppression, and about 40% of transplanted organs survive no more than five years.
Through Aditxt, Adimune
has the right to use to the exclusive worldwide license for commercializing ADI™ nucleic acid-based technology (which
is currently at the pre-clinical stage) from Loma Linda University (“LLU”). ADI™ uses a novel approach that mimics
the way the body naturally induces tolerance to our own tissues (“therapeutically induced immune tolerance”). While immune
suppression requires continuous administration to prevent rejection of a transplanted organ, induction of tolerance has the potential
to retrain the immune system to accept the organ for more extended periods of time. ADI™ may allow patients to live
with transplanted organs with significantly reduced immune suppression. ADI™ is a technology platform which we believe
can be engineered to address a wide variety of indications.
Advantages
ADI™ is a nucleic
acid-based technology (e.g., DNA-based), which we believe selectively suppresses only those immune cells involved in attacking
or rejecting self and transplanted tissues and organs. It does so by tapping into the body’s natural cell turnover process (i.e.,
apoptosis) to retrain the immune system to stop unwanted attacks on self or transplanted tissues. Apoptosis is a natural process used
by the body to clear dying cells and to allow recognition and tolerance to self-tissues. ADI™ triggers this process
by enabling immune system cells to recognize the targeted tissues as “self.” Conceptually, it is designed to retrain the
immune system to accept the tissues, similar to how natural apoptosis reminds our immune system to tolerate to our own “self”
tissues.
While various groups
have promoted tolerance through cell therapies and ex vivo manipulation of patient cells (i.e., takes place outside
the body), to our knowledge, we will be unique in our approach of using in-body induction of apoptosis to promote tolerance to specific
tissues. In addition, ADI™ treatment itself will not require additional hospitalization but only an injection of
minute amounts of the therapeutic drug into the skin.
Moreover, preclinical
studies have demonstrated that ADI™ treatment significantly and substantially prolongs graft survival, in addition to
successfully “reversing” other established immune-mediated inflammatory processes.
License Agreement with Loma Linda University
On March 15, 2018, we entered into a License
Agreement with LLU (the “LLU License Agreement”), which was subsequently amended on July 1, 2020. Pursuant to the LLU License
Agreement, we obtained the exclusive royalty-bearing worldwide license to all intellectual property, including patents, technical information,
trade secrets, proprietary rights, technology, know-how, data, formulas, drawings, and specifications, owned or controlled by LLU and/or
any of its affiliates and related to therapy for immune-mediated inflammatory diseases (the ADI™ technology). In consideration
for the LLU License Agreement, we issued 25,000 shares of common stock to LLU.
PEARSANTA
Pearsanta, Inc. (Pearsanta”) is focused
on precision health, leveraging cutting-edge diagnostic technologies for disease detection and management. We believe that timely and
personalized testing enables far more informed treatment decisions. Pearsanta aims to empower consumers to monitor their health more
proactively, offering a complete picture of someone’s dynamic health status, including genetic makeup and medication response.
Central to Pearsanta’s innovation are the AditxtScore™ technology platform and the Mitomic® Technology Platform, which
we acquired from MDNA Life Sciences, Inc. (“MDNA”) in January 2024.
Licensed Technologies – AditxtScore™
We have sublicensed
to Pearsanta, an exclusive worldwide sublicense for commercializing the AditxtScore™ technology, which provides a personalized,
comprehensive immune system profile. AditxtScore™ is intended to detect individual immune responses to viruses, bacteria,
peptides, drugs, supplements, bone marrow and solid organ transplants, and cancer. It also has broad applicability to many other agents
of clinical interest impacting the immune system, including those not yet identified, such as emerging infectious agents.
AditxtScore™
is being developed to enable individuals and their healthcare providers to understand, manage, and monitor their immune profiles
and to stay informed about attacks on or by their immune system. AditxtScore can also assist the medical community and individuals by
anticipating the immune system’s potential response to viruses, bacteria, allergens, and foreign tissues such as transplanted organs.
This technology may be able to serve as a warning signal, thereby allowing for more time to respond appropriately. Its advantages include
providing simple, rapid, accurate, high throughput assays that can be multiplexed to determine the immune status concerning several factors
simultaneously in approximately 3-16 hours. Additionally, it can evaluate and differentiate between distinct types of cellular and humoral
immune responses (e.g., T and B cells and other cell types). It also provides for simultaneous monitoring of cell activation and levels
of cytokine release (i.e., cytokine storms).
We are actively involved
in the regulatory approval process for AditxtScore™ assays for clinical use and securing manufacturing, marketing, and
distribution partnerships for application in various markets. To obtain regulatory approval to use AditxtScore™ as a
clinical assay, we have conducted validation studies to evaluate its performance in detecting antibodies and plan to continue conducting
additional validation studies for new applications in autoimmune diseases.
Advantages
The sophistication of
the AditxtScore technology includes the following:
|
● |
greater sensitivity/specificity; |
|
● |
20-fold higher dynamic
range, greatly reducing signal to noise compared to conventional assays; |
|
● |
ability to customize assays
and multiplex a large number of analytes with speed and efficiency; |
|
● |
ability to test for cellular
immune responses (i.e., T and B cells and cytokines); and |
|
● |
proprietary reporting algorithm. |
License Agreement with Leland Stanford Junior University (“Stanford”)
On February 3, 2020, we entered into an exclusive
license agreement (the “February 2020 License Agreement”) with Stanford regarding a patent concerning a method for detection
and measurement of specific cellular responses. Pursuant to the February 2020 License Agreement, we received an exclusive worldwide license
to Stanford’s patent with regard to use, import, offer, and sale of Licensed Products (as defined in the February 2020 License
Agreement). The license to the patented technology is exclusive, including the right to sublicense, beginning on the effective date of
the agreement, and ending when the patent expires. Under the exclusivity agreement, we acknowledged that Stanford had already granted
a non-exclusive license in the Nonexclusive Field of Use, under the Licensed Patents in the Licensed Field of Use in the Licensed Territory
(as those terms are defined in the February 2020 License Agreement). However, Stanford agreed not to grant further licenses under the
Licensed Patents in the Licensed Field of Use in the Licensed Territory. On December 29, 2021, we entered into an amendment to the February
2020 License Agreement which extended our exclusive right to license the technology deployed in AditxtScore™ and
securing worldwide exclusivity in all fields of use of the licensed technology.
Mitomic® Technology Platform
In January 2024, we acquired the assets comprising
our mitomic technology platform from MDNA. This platform seeks to harness the unique properties of mitochondrial DNA (“mtDNA”)
to detect disease through non-invasive, blood-based liquid biopsies.
The Mitomic® Technology Platform is designed
to identify specific mutations in mtDNA indicative of various diseases. Due to its high mutation rate and cell persistence, mitochondrial
DNA is an excellent biomarker for early disease detection. This platform allows for the rapid and accurate identification of disease-associated
biomarkers, which can significantly enhance early diagnosis and treatment.
Key Products Under Development at Time of
Acquisition:
Mitomic® Endometriosis Test (MET™):
|
● |
Purpose: To provide an
accurate and non-invasive diagnosis of endometriosis, a condition that affects approximately 1 in 10 women of reproductive age worldwide. |
|
● |
Clinical Validation: MET™
has demonstrated high accuracy in predicting surgical outcomes in women suspected of having endometriosis. The test has shown significant
promise in reducing the diagnostic delay, which averages around ten years. |
|
● |
Impact: Early and precise
diagnosis through MET™ can lead to timely and effective treatment, significantly improving patient outcomes and quality of
life |
Mitomic® Prostate Test (MPT™):
|
● |
Purpose: To enhance the
detection of clinically significant prostate cancer, reducing reliance on PSA testing, which often results in false positives and
over-diagnosis. |
|
● |
Clinical Validation: MPT™
has shown the ability to predict prostate cancer accurately, distinguishing between aggressive and non-aggressive forms. This specificity
is crucial in guiding treatment decisions and reducing unnecessary interventions. |
|
● |
Impact: MPT™ aims
to improve patient outcomes by ensuring that only those with clinically significant prostate cancer receive treatment, thereby avoiding
the side effects of unnecessary procedures. |
To date, our primary focus with respect to the
Mitomic Technology Platform has been the integration of such assets into our business. Our initial plans for the Mitomic Technology Platform
are to complete product development, manufacturing and clinical validation of the MET™ and the MPT™.:
BRAIN SCIENTIFIC
We do not believe that precision health is limited
to biochemical or immunological testing data. We continue to seek to identify platform technologies that enhance our portfolio of product
lines that meet our vision of improving health by providing better access to care and developing innovative therapies. We believe that
neurological testing also provides important information regarding brain health. We identified certain assets that were then subject
to an insolvency proceeding that we believe have the potential to expand the use of EEG recordings more easily and make them more accessible
in decentralized locations. We believe that these assets also have the potential to gather and process data obtained from various media
(e.g. electroencephalogram (“EEG”) recordings, MRI and other imaging media) to assist with more complex diagnoses.
In January 2024, we entered an Assignment and
Assumption Agreement (the “Brain Assignment Agreement”) with the agent (the “Agent”) of certain secured creditors
(the “Brain Creditors”) of Brain Scientific, Inc., a Nevada corporation (“Brain Scientific”) and Philip J. von
Kahle (the “Brain Seller”), as assignee of Brain Scientific and certain affiliated entities (collectively, the “Brain
Companies”) under an assignment for the benefit of creditors pursuant to Chapter 727 of the Florida Statutes. Pursuant to the Brain
Assignment Agreement, the Agent assigned its rights under that certain Asset Purchase and Settlement Agreement dated October 31, 2023
between the Brain Seller and the Agent (the “Brain Asset Purchase Agreement”) to the Company in consideration for the issuance
by the Company of an aggregate of 6,000 shares of our newly designated Series B-1 Convertible Preferred Stock. In connection
with the Brain Assignment Agreement, we entered into a patent assignment with the Brain Seller, pursuant to which the Brain Seller assigned
all of its rights, titles and interests in certain patents and patent applications that were previously held by the Brain Companies to
us. The intellectual property acquired relates to certain neurology products and motion products.
Neurology Products
The neurology products were designed to simplify
the completion of EEG recordings in a more ambulatory setting. The NeuroCap™ and NeuroEEG™ products,
which were 510K FDA cleared pre-launch ready, are focused on providing efficient tools to the EEG medical market. These technologies
were designed to allow a miniature, wireless, clinical device capable of recording an EEG and provide the data to medical staff without
the need to use bulky hardware or a neurology technician for the placement of the cap.
The NeuroCap™ is an FDA-cleared
disposable, soft layered cap with an integrated electrode circuit designed to address conventional EEG systems’ existing problems.
The silver embedded wiring is pre-gelled, requiring no preparation of the skin before application. NeuroCap™ makes it
possible for medical staff of all levels to perform EEG tests, without having to laboriously apply electrodes one-by-one or spend considerable
time cleaning an EEG headset after each use.
The NeuroCap™ works in parallel
with the NeuroEEG™ amplifier device to carry out EEG tests. The NeuroCap™ can also work with other
EEG devices. The NeuroCap™’s electrode placement follows standard alignment pursuant to the international 10-20
system. The acquisition of electrical brain activity is carried out by non-invasive pre-gelled passive Ag/AgCl scalp (cutaneous) electrodes,
ensuring maximum comfort for the wearer.
The motion products are small piezoelectric motors
which are designed for and expected to have valuable and beneficial uses as motors within medical devices and devices outside of the
MedTech industry. We believe that these technologies will help us expand our technology focused products.
ADIVIR
Formed in April of 2023,
Adivir™, Inc. (“Adivir”) is Aditxt’s most recently formed wholly owned subsidiary, dedicated to the clinical
and commercial development efforts of innovative antiviral products, which have the potential to address a wide range of infectious diseases,
including those that currently lack viable treatment options.
Background
On April 18, 2023, we
entered into an Asset Purchase Agreement (the “Asset Purchase Agreement”) with Cellvera Global Holdings LLC (“Cellvera
Global”), Cellvera Holdings Ltd. (“BVI Holdco”), Cellvera, Ltd. (“Cellvera Ltd.”), Cellvera Development
LLC (“Cellvera Development” and together with Cellvera Global, BVI Holdco, Cellvera Ltd. and Cellvera Development (the “Sellers”),
AiPharma Group Ltd. (“Seller Owner” and collectively with the Sellers, “Cellvera”), and the legal representative
of Cellvera, pursuant to which, the Company will purchase Cellvera’s 50% ownership interest in G Response Aid FZE (“GRA”),
certain other intellectual property and all goodwill related thereto (the “Acquired Assets”). Unless expressly stated
otherwise herein, capitalized terms used but not defined herein have the meanings ascribed to them in the Asset Purchase Agreement. Pursuant
to the Asset Purchase Agreement, the consideration for the Acquired Assets consists of (A) $24.5 million, comprised of: (i) the
forgiveness of the Company’s $14.5 million loan to Cellvera Global, and (ii) approximately $10 million in cash, and (B) future
revenue sharing payments for a term of seven years. GRA holds an exclusive, worldwide license for the antiviral medication, Avigan®
200mg, excluding Japan, China and Russia. The other 50% interest in GRA is held by Agility, Inc. (“Agility”).
Additionally, upon the
closing, the share exchange agreement previously entered into as of December 28, 2021, between Cellvera f/k/a AiPharma Global Holdings,
LLC (together with other affiliates and subsidiaries) and the Company, and all other related agreements, will be terminated.
The obligations of the
Company to consummate the closing under the Asset Purchase Agreement are subject to the satisfaction or waiver, at or prior to the closing
of certain conditions, including but not limited to, the following:
|
(i) |
Satisfactory completion
of due diligence; |
|
(ii) |
Completion by the Company
of financing sufficient to consummate the transactions contemplated by the Asset Purchase Agreement; |
|
(iii) |
Receipt by the Company
of all required consents from governmental bodies for the acquisition, including but not limited to, any consents required to complete
the transfer and assignment of Cellvera’s membership interests in GRA; |
|
(iv) |
Receipt of executed payoff
letters reflecting the amount required to be fully pay all of each of Seller’s and Seller Owner’s debt to be paid at
closing; |
|
(v) |
Receipt by the Company
of a release from Agility; |
|
(vi) |
Execution of an agreement
acceptable to the Company with respect to the acquisition by the Company of certain intellectual property presently held by a third
party; |
|
(vii) |
Execution of an amendment
to an asset purchase agreement previously entered into by Cellvera with a third party that effectively grants the Company the rights
to acquire the intellectual property from the third party under such agreement; |
|
(viii) |
Receipt of a fairness opinion
by the Company with respect to the transactions contemplated by the Asset Purchase Agreement; and |
|
(ix) |
Receipt by the Company
from the Seller Owner of written consent, whether through its official liquidator or the board of directors of Seller Owner, to the
sale and purchase of the acquired assets and assumed liabilities pursuant to the Asset Purchase Agreement. |
There can be no assurance
that the conditions to closing will be satisfied or that the proposed acquisition will be completed as proposed or at all.
Our commitment to building
our antiviral portfolio is strategic and timely. We believe that there has never has there been a more important time to address the
growing global need to uncover new treatments or commercialize existing ones that treat life-threatening global viral infections.
Recent Developments
Reverse Stock Split
At our Annual Meeting,
our stockholders approved a proposal to amend our certificate of incorporation to effect a reverse split of our outstanding shares of
common stock at a specific ratio within a range of one-for five (1:for:5) to a maximum of one-for-two hundred (1:for:200), with the exact
ratio to be determined by our board of directors in its sole discretion.
Following the Annual
Meeting, our board of directors approved a one-for-forty (1-for-40) reverse split of our issued and outstanding shares of common stock
(the “Reverse Stock Split”). On October 1, 2024, we filed with the Secretary of State of the State of Delaware a certificate
of amendment to our certificate of incorporation (the “Certificate of Amendment”) to effect the Reverse Stock Split. The
Reverse Stock Split became effective as of 4:01 p.m. Eastern Time on October 1, 2024, and the Company’s common stock began trading
on a split-adjusted basis when the Nasdaq Stock Market opened on October 2, 2024.
Market Development Collaboration Agreement
On September 18, 2024, Pearsanta, Inc., a subsidiary
of the Company (“Pearsanta”) entered into a Market Development Collaboration Agreement (the “Collaboration Agreement”)
with Evofem Biosciences, Inc. (“Evofem”), pursuant to which Pearsanta and Evofem agreed to collaborate on the development
of the go-to-market plan for the planned launch of Pearsanta’s Mitomic Endometriosis Test (the “MET”). In addition,
pursuant to the Collaboration Agreement, Pearsanta granted Evofem a right of first refusal (the “ROFR”) with respect
to the distribution of the MET for a period of 24 months from the execution of the Collaboration Agreement (the “ROFR Term”).
Under the Collaboration Agreement, the ROFR will only be triggered if during the ROFR Term: (i) Pearsanta or any of its affiliates or
successors seeks to distribute MET in the U.S.; and (ii) Evofem has accomplished all of the agreed-upon milestones set forth in the Collaboration
Agreement.
September 2024 Senior Note
On September 17, 2024, we issued and sold a senior
note (the “Note”) to an accredited investor (the “Holder”) in the original principal amount of $923,077 for a
purchase price of $600,000, reflecting an original issue discount of $323,077. The Note does not bear interest and has a maturity date
of the earlier of (i) June 18, 2025 and (ii) the initial time of consummation by the Company after the date hereof of any public or private
offering(s), individually or in the aggregate, of securities with gross proceeds of at least $1 million. We may prepay any portion of
the outstanding principal of the Note at any time without penalty. So long as any amounts remain outstanding under the Note, 30% of the
gross proceeds received by the Company on or after the date hereof from sales of common stock of the Company pursuant to any at-the-market
offering, equity-line or other similar transaction shall be used to repay the Note. The Note contains certain standard events of default,
as defined in the Note.
Senior Note Waiver and Side Letter
On August 28, 2024, we entered into a Waiver
to Senior Note (the “Waiver”) with each of the holders of the May Senior Notes (defined below), pursuant to which effective
as of August 21, 2024, each holder waived, in part, the definition of Maturity Date in the May Senior Note, such that the August 22,
2024 shall be deemed to be replaced with September 30, 2024. In connection with the Waiver, we also entered into a letter agreement (the
“Letter Agreement”) with each of the holders, pursuant to which we agreed that we would apply 40% of the net proceeds from:
(i) any sales of securities utilizing our currently effective Registration Statement on Form S-3 (a “Shelf Takedown”), (ii)
sales of our common stock under its Common Stock Purchase Agreement dated May 2, 2023 with the Selling Stockholder (the “ELOC”),
or (iii) any public offering of securities registered in a Registration Statement on Form S-1 (a “Public Offering”), to make
payments on the May Senior Notes and the July Senior Notes (defined below). In addition, pursuant to the Letter Agreement, commencing
on the date that the May Senior Notes and July Senior Notes have been repaid in full, we shall redeem all holders (each, a “Series
C-1 Holder”) of our then outstanding Series C-1 Convertible Preferred Stock (ratably based on the amount of Preferred Stock then
held by each Series C-1 Holder) in an amount equal to, in the aggregate among all Series C-1 Holders, 40% of the net proceeds raised
from any Shelf Takedowns, any sales of common stock under the ELOC or any Public Offering (“Non-Participation Redemption”).
In addition to the foregoing Non-Participation Redemption, in connection with any Shelf Takedown or Public Offering, in the event that
a Series C-1 Holder participates in such Shelf Takedown or a Public Offering, we shall, in addition to the amounts paid to such Series
C-1 Holder in the foregoing sentence, use 50% of the gross proceeds received in such Shelf Takedown or Public Offering from such Series
C-1 Holder to redeem such Series C-1 Holder’s shares of Series C-1 Convertible Preferred Stock.
Payment Agreement
On August 14, 2024, we entered into a Payment
Agreement with H.C. Wainwright & Co., LLC (the “Payment Agreement”), pursuant to which we agreed (i) on or prior to September
15, 2024, to pay Wainwright $162,206.96 of certain outstanding fees from our May 2024 private placement and to issue warrants to purchase
96,786 shares of the Company’s common stock at an exercise price of $3.2438 per share, commencing six months following issuance
for a term of five years from the date of issuance and (ii) on or prior to October 15, 2024, to pay the remaining $162,206 of the outstanding
fees from our May 2024 private placement. In addition, pursuant to the Payment Agreement, the Company agreed to make one-time cash payment
of $190,000 to Wainwright in satisfaction of certain obligations of Evofem Biosciences, Inc. (“Evofem”) to Wainwright no
later than five days following the closing of our merger with Evofem (the “Wainwright Evofem Payment”), provided however,
that we shall not be obligated to pay the Wainwright Evofem Payment in the event that the merger has not closed by October 15, 2024 or
the merger is terminated.
August 2024 Registered Direct Offering
On August 8, 2024, we
entered into a securities purchase agreement (the “Purchase Agreement”) with certain institutional investors, pursuant to
which we sold to such investors 188,000 shares of common stock, pre-funded warrants (the “Pre-Funded Warrants”) to purchase
up to 942,189 shares of common stock, having an exercise price of $0.001 per share, at a purchase price of $1.06 per share of common
stock and a purchase price of $1.059 per Pre-Funded Warrant (the “Offering”). The shares of common stock and Pre-Funded Warrants
(and shares of common stock underlying the Pre-Funded Warrants) were offered by the Company pursuant to its shelf registration statement
on Form S-3 (File No. 333-280757), which was declared effective by the Securities and Exchange Commission on August 6, 2024. The closing
of the sales of these securities under the Purchase Agreement took place on August 9, 2024.
August 2024 Exchange Agreement
On August 7, 2024, we
entered into a Securities Exchange Agreement (the “Exchange Agreement”) with the an institution investor (the “Holder”)
(the “Exchange Agreement”), pursuant to we agreed to exchange pre-funded warrants to purchase up to 1,237,114 shares of our
common stock, par value $0.001 per share (“Common Stock”) at an exercise price of $0.001 per share for: (i) an aggregate
of 6,667 shares of our Series C-1 Convertible Preferred Stock, par value $0.001 per share (the “Series C-1 Preferred Stock”),
and (ii) warrants to purchase 2,569,171 shares of at an exercise price of $1.49 per share for a term of five years (the “Exchange
Warrants”).
Increase in Authorized Common Stock
On August 7, 2024, we filed with the Secretary of State of Delaware
an amendment to the Company’s Certificate of Incorporation, to increase the number of authorized common stock from 100,000,000
shares to 1,000,000,000 shares.
Amended and Restated Agreement and Plan of Merger
On July 12, 2024 (the
“Execution Date”), the Company entered into an Amended and Restated Agreement and Plan of Merger (the “Merger Agreement”)
with Adifem, Inc. f/k/a Adicure, Inc., a Delaware corporation and wholly owned subsidiary of the Company (“Merger Sub”) and
Evofem Biosciences, Inc., a Delaware corporation (“Evofem”), pursuant to which, Merger Sub will be merged into and with Evofem
(the “Merger”), with Evofem surviving the Merger as a wholly owned subsidiary of the Company. The Merger Agreement amended
and restated that certain Agreement and Plan of Merger dated as of December 11, 2023, as subsequently amended as described below, by
and among the Company, Merger Sub and Evofem (as amended, the “Original Agreement”).
On January 8, 2024,
the Company, Adicure and Evofem entered into the First Amendment to the Merger Agreement (the “First Amendment to Merger Agreement”),
pursuant to which the parties agreed to extend the date by which the joint proxy statement would be filed with the SEC until February
14, 2024. On January 30, 2024, the Company, Adicure and Evofem entered into the Second Amendment to the Merger Agreement (the “Second
Amendment to Merger Agreement”) to amend (i) the date of the Parent Loan (as defined in the Merger Agreement) to Evofem to
be February 29, 2024, (ii) to change the date by which Evofem may terminate the Merger Agreement for failure to receive the Parent Loan
to be February 29, 2024, and (iii) to change the filing date for the Joint Proxy Statement (as defined in the Merger Agreement) to April
1, 2024. On February 29, 2024, the Company, Adicure and Evofem entered into the Third Amendment to the Merger Agreement (the
“Third Amendment to Merger Agreement”) in order to (i) make certain conforming changes to the Merger Agreement regarding
the Notes, (ii) extend the date by which the Company and Evofem will file the joint proxy statement until April 30, 2024, and (iii) remove
the requirement that the Company make the Parent Loan (as defined in the Merger Agreement) by February 29, 2024 and replace it with the
requirement that the Company make an equity investment into Evofem consisting of (a) a purchase of 2,000 shares of Evofem Series F-1
Preferred Stock for an aggregate purchase price of $2.0 million on or prior to April 1, 2024, and (b) a purchase of 1,500 shares of Evofem
Series F-1 Preferred Stock for an aggregate purchase price of $1.5 million on or prior to April 30, 2024. On April 26, 2024, the
Company received notice from Evofem (the “Termination Notice”) that Evofem was exercising its right to terminate the Merger
Agreement as a result of the Company’s failure to provide the Initial Parent Equity Investment (as defined in the Merger Agreement,
as amended).
On May 2, 2024, the
Company, Adifem, Inc. f/k/a Adicure, Inc. and Evofem entered into the Reinstatement and Fourth Amendment to the Merger Agreement (the
“Fourth Amendment”) in order to waive and amend, among other things, the several provisions listed below.
Amendments to Article
VI: Covenants and Agreement
Article VI of the Merger
Agreement is amended to:
|
● |
reinstate the Merger Agreement,
as amended by the Fourth Amendment, as if never terminated; |
|
● |
reflect the Company’s
payment to Evofem, in the amount of $1,000,000 (the “Initial Payment”), via wire initiated by May 2, 2024; |
|
● |
delete Section 6.3, which
effectively eliminates the “no shop” provision, and the several defined terms used therein; |
|
● |
add a new defined term
“Company Change of Recommendation;” and |
|
● |
revise section 6.10 of
the Merger Agreement such that, after the Initial Payment, and upon the closing of each subsequent capital raise by the Company (each
a “Parent Subsequent Capital Raise”), the Company shall purchase that number of shares of Evofem’s Series
F-1 Preferred Stock, par value $0.0001 per share (the “Series F-1 Preferred Stock”), equal to forty percent (40%)
of the gross proceeds of such Parent Subsequent Capital Raise divided by 1,000, up to a maximum aggregate amount of $2,500,000 or
2,500 shares of Series F-1 Preferred Stock. A maximum of $1,500,000 shall be raised prior to June 17, 2024 and $1,000,000 prior to
July 1, 2024 (the “Parent Capital Raise”). |
Amendments to Article
VIII: Termination
Article VIII of the
Merger Agreement is amended to:
|
● |
extend the date after which
either party may terminate from May 8, 2024 to July 15, 2024; |
|
● |
revise Section 8.1(d) in
its entirety to allow Company to terminate at any time after there has been a Company Change of Recommendation, provided that Aditxt
must receive ten day written notice and have the opportunity to negotiate a competing offer in good faith; and |
|
|
|
|
● |
amend and restate Section
8.1(f) in its entirety, granting the Company the right to terminate the agreement if (a) the full $1,000,000 Initial Payment required
by the Fourth Amendment has not been paid in full by May 3, 2024 (b) $1,500,000 of the Parent Capital Raise Amount has not been paid
to the Company by June 17, 2024, (c) $1,000,000 of the Parent Capital Raise Amount has not been paid to the Company by July 1, 2024,
or (d) Aditxt does not pay any portion of the Parent Equity Investment within five calendar days after each closing of a Parent Subsequent
Capital Raise. |
Except as described
below, the terms and conditions of the Merger Agreement are consistent with the terms and provisions of the Original Agreement.
Effect on Capital
Stock
Subject to the terms
and conditions set forth in the Merger Agreement, at the effective time of the Merger (the “Effective Time”), (i) all issued
and outstanding shares of common stock, par value $0.0001 per share of Evofem (“Evofem Common Stock”), other than any shares
of Evofem Common Stock either held by the Company or Merger Sub immediately prior to the Effective Time or which are Dissenting Shares
(as hereinafter defined), will be converted into the right to receive an aggregate of $1,800,000; and (ii) each issued and outstanding
share of Series E-1 Preferred Stock, par value $0.0001 of Evofem (the “Evofem Unconverted Preferred Stock”), other than any
shares of Evofem Unconverted Preferred Stock either held by the Company or Merger Sub immediately prior to the Effective Time or which
are Dissenting Shares, will be converted into the right to receive one (1) share of Series A-2 Preferred Stock, par value $0.001 of the
Company (the “Company Preferred Stock”), having such rights, powers, and preferences set forth in the form of Certificate
of Designation of Series A-2 Preferred Stock, the form of which is attached as Exhibit C to the Merger Agreement.
Any Evofem capital stock
outstanding immediately prior to the Effective Time and held by an Evofem shareholder who has not voted in favor of or consented to the
adoption of the Merger Agreement and who is entitled to demand and has properly demanded appraisal for such Company Capital Stock in
accordance with the Delaware General Corporation Law (“DGCL”), and who, as of the Effective Time, has not effectively withdrawn
or lost such appraisal rights (such Evofem capital Stock, “Dissenting Shares”) shall not be converted into or be exchangeable
for the right to receive a portion of the Merger Consideration and, instead, shall be entitled to only those rights as set forth in the
DGCL. If, after the Effective Time, any such holder fails to perfect or withdraws or loses his, her or its right to appraisal under the
DGCL, with respect to any Dissenting Shares, upon surrender of the certificate(s) representing such Dissenting Shares, such Dissenting
Shares shall thereupon be treated as if they had been converted as of the Effective Time into the right to receive the portion of the
merger consideration, if any, to which such Evofem capital stock is entitled pursuant to the Merger Agreement, without interest.
As a closing condition
for the Company, there shall be no more than 4,141,434 Dissenting Shares that are Evofem Common Stock or 98 Dissenting Shares that are
Evofem Preferred Stock.
At the Effective Time,
each option outstanding under the Evofem 2014 Equity Incentive Plan, the Evofem 2018 Inducement Equity Incentive Plan and the Evofem
2019 Employee Stock Purchase Plan (collectively, the “Evofem Option Plans”), whether or not vested, will be canceled
without the right to receive any consideration, and the board of directors of Evofem shall take such action such that the Evofem Option
Plans are cancelled as of the Effective Time.
As soon as practicable
following the Execution Date, Evofem will take all action that may be reasonably necessary to provide that: (i) no new offering period
will commence under the Evofem 2019 Employee Stock Purchase Plan (the “Evofem ESPP”); (ii) participants in the Evofem
ESPP as of the Execution Date shall not be permitted to increase their payroll deductions or make separate non-payroll contributions
to the Evofem ESPP; and (iii) no new participants may commence participation in the Evofem ESPP following the Execution Date. Prior to
the Effective Time, Evofem will take all action that may be reasonably necessary to: (A) cause any offering period or purchase period
that otherwise be in progress at the Effective Time to be the final offering period under the Evofem ESPP and to be terminated no later
than five business days prior to the anticipated closing date (the “Final Exercise Date”); (B) make any pro-rata adjustments
that may be necessary to reflect the shortened offering period or purchase period; (C) cause each participant’s then-outstanding
share purchase right under the Evofem ESPP to be exercised as of the Final Exercise Date; and (D) terminate the Evofem ESPP, as of and
contingent upon, the Effective Time.
On August 16, 2024, the Company, Merger Sub and
Evofem entered into Amendment No. 1 to the Amended and Restated Merger Agreement (“Amendment No. 1”), pursuant to which the
date by which the Company is to make the Third Parent Equity Investment was amended to the earlier of September 6, 2024 or five
(5) business days of the closing of a public offering by Parent resulting in aggregate net proceeds to Parent of no less than $20,000,000.
On September 6, 2024, the Company, Merger
Sub and Evofem entered into Amendment No. 2 to the Amended and Restated Merger Agreement (“Amendment No. 2”), pursuant to
which the date by which the Company shall make the Third Parent Equity Investment was amended from September 6, 2024 to September
30, 2024 and to adjust the amount of such investment from $2 million to $1.5 million, and to extend the date by which Aditxt shall make
the Fourth Parent Equity Investment (as defined under the Amended and Restated Merger Agreement) was amended from September 30, 2024
to October 31, 2024 and adjust the amount of such investment from $1 million to $1.5 million.
On October 2, 2024, the Company, Merger
Sub and Evofem entered into Amendment No. 3 to the Amended and Restated Merger Agreement (“Amendment No. 3”) in order to
extend the date by which the Company shall make the Third Parent Equity Investment to October 2, 2024, reduce the amount of the Third
Parent Equity Investment from $1.5 million to $720,000, and increase the amount of the Fourth Parent Equity Investment from $1.5 million
to $2.28 million.
Securities Purchase Agreement – Evofem
Series F-1 Convertible Preferred Stock
On July 12, 2024 (the “Closing Date”),
the Company completed the Initial Parent Equity Investment (as defined under the Merger Agreement) and entered into a Securities Purchase
(the “Series F-1 Securities Purchase Agreement”) with Evofem, pursuant to which the Company purchased 500 shares of Evofem’s
Series F-1 Convertible Preferred Stock par value $0.0001 per share (“Evofem F-1 Preferred Stock”) for an aggregate purchase
price of $500,000. In connection with the Series F-1 Securities Purchase Agreement, the Company and Evofem entered into a Registration
Rights Agreement (the “Registration Rights Agreement”), pursuant to which Evofem agreed to file with the SEC a registration
statement covering the resale of the shares of its common stock issuable upon conversion of the Evofem Series F-1 Preferred Stock within
300 days of the Closing Date and to have such registration statement declared effective by the SEC the earlier of the (i) 90th calendar
day after the Closing Date and (ii) 2nd Business Day after the date Evofem is notified (orally or in writing, whichever
is earlier) by the SEC that such registration statement will not be reviewed or will not be subject to further review.
Pursuant to the Merger Agreement, the Company
is also obligated to purchase: (i) an additional 500 shares of Evofem Series F-1 Preferred Stock for an additional aggregate purchase
price of $500,000 on or prior to August 9, 2024; (ii) an additional 2,000 shares of Evofem Series F-1 Preferred Stock for an additional
purchase price of $2 million on the earlier of August 30, 2024 or 5 business days of the closing of a public offering by the Company
resulting in aggregate net proceeds to the Company of no less than $20 million; and (iii) an additional 1,000 shares of Evofem Series
F-1 Preferred Stock for an additional purchase price of $1 million on or prior to September 30, 2024.
On September 18, 2024 (the “Closing Date”),
we entered into a Securities Purchase (the “Series F-1 Securities Purchase Agreement”) with Evofem, pursuant to which we
purchased 260 shares of Evofem’s Series F-1 Preferred Stock for an aggregate purchase price of $260,000. In connection with the
Series F-1 Securities Purchase Agreement, the Company and Evofem entered into a Registration Rights Agreement (the “Registration
Rights Agreement”), pursuant to which Evofem agreed to file with the SEC a registration statement covering the resale of the shares
of its common stock issuable upon conversion of the Evofem Series F-1 Preferred Stock within 300 days of the Closing Date and to have
such registration statement declared effective by the SEC the earlier of the (i) 90th calendar day after the Closing
Date and (ii) 2nd Business Day after the date Evofem is notified (orally or in writing, whichever is earlier) by the
SEC that such registration statement will not be reviewed or will not be subject to further review.
On October 2, 2024, the Company entered into a Securities Purchase
Agreement (the “Series F-1 Securities Purchase Agreement”) with Evofem Biosciences, Inc. (“Evofem”),
pursuant to which the Company purchased 460 shares of Evofem F-1 Preferred Stock for an aggregate purchase price of $460,000. In connection
with the Series F-1 Securities Purchase Agreement, the Company and Evofem entered into a Registration Rights Agreement (the “Registration
Rights Agreement”), pursuant to which Evofem agreed to file with the SEC a registration statement covering the resale of the
shares of its common stock issuable upon conversion of the Evofem Series F-1 Preferred Stock within 300 days of the Closing Date and
to have such registration statement declared effective by the SEC the earlier of the (i) 90th calendar day after the
Closing Date and (ii) 2nd Business Day after the date Evofem is notified (orally or in writing, whichever is earlier)
by the SEC that such registration statement will not be reviewed or will not be subject to further review.
Promissory Note
On April 10, 2024, Sixth
Borough Capital Fund, LP (“Sixth Borough”) loaned the Company $230,000. The loan was evidenced by an unsecured promissory
note (the “Sixth Borough April Note”). Pursuant to the terms of the Sixth Borough April Note, it will accrue interest at
the prime rate of 8.5% per annum and is due on the earlier of April 19, 2024 or an event of default, as defined therein. On May 9, 2024,
at which point the balance of the loan was $35,256, Sixth Borough loaned an additional $20,000 to the Company, bringing the balance of
the loan to $55,256.03. The loan was evidenced by an unsecured promissory note (the “Upsize Note”). Pursuant to the terms
of the Upsize Note, it accrued interest at the 15% per annum and was due on the earlier of June 9, 2024 (the “Maturity Date”)
or an event of default, as defined therein. The Company failed to repay the balance on the Maturity Date, and as such was in default
on the Upsize Note.
On June 20, 2024, at which point the balance
of the Upsize Note was $56,187, Sixth Borough loaned an additional $50,000 to the Company and the Company issued a new note (the “New
Note”) to Sixth Borough in the principal amount of $116,806, which includes an original issue discount of 10%. The New Note is
subordinate and junior, in all respects, to those certain senior notes in the aggregate principal amount of $986,380 due August 22, 2024
issued by the Company on May 22, 2024 (the “May 2024 Senior Notes”). The New Note bears interest at a rate of 8% per annum
and is due on the earlier of (i) November 21, 2024; or (ii) at or before the final closing of the next series of public or private financings,
totaling $750,000 or more in the aggregate by the Company, subject to the prior payment in full of all amounts then owing on the May
2024 Senior Notes; or (iii) an Event of Default (as defined in the New Note).
Lease Default
The Company is party to a lease agreement dated
as of May 4, 2021 by and between LS Biotech Eight, LLC (the “Landlord”) and the Company (the “Lease”). On May
10, 2024, the Company received written notice (the “Lease Default Notice”) from the Landlord that the Company was in violation
of its obligation to (i) pay Base Rent (as defined in the Lease) and Additional Rent (as defined in the Lease) in the amount of $431,182.32
in the aggregate, together with administrative charges and interest, as well as (ii) replenish the Security Deposit (as defined in the
Lease) in the amount of $159,375.00, all as required under the Lease. Pursuant to the Lease Default Notice, the Landlord has demanded
that a payment of $590,557.31 plus administrative charges and interest, which shall accrue at the Default Rate (as defined in the Lease)
be made no later than May 17, 2024. On July 18, 2024 the Company made a payment of $86,279 against the outstanding balance. The Company
and the Landlord are currently in talks to agree upon a payment plan.
The Company is working with the Landlord to come
to an amicable resolution. However, no assurance can be given that the parties will reach an amicable resolution on a timely basis, on
favorable terms, or at all.
Equity Line of Credit
On May 2, 2024, we entered into a common stock
purchase agreement (the “Purchase Agreement”) with Seven Knots, pursuant to which Seven Knots has agreed to purchase from
us, at our direction from time to time, from and after the date effective date of this prospectus and until the termination of the Purchase
Agreement, shares of our common stock having a total maximum aggregate purchase price of $150,000,000, upon the terms and subject to
the conditions and limitations set forth in the Purchase Agreement. See “Seven Knots Transaction” for a description of the
Purchase Agreement and additional information regarding Seven Knots.
May 2024 Private Placement
On May 2, 2024, we entered
into a securities purchase agreement (the “Purchase Agreement”) with certain accredited investors, pursuant to which we agreed
to issue and sell to such investors in a private placement (the “Private Placement”): (i) an aggregate of 4,186 shares of
our Series C-1 Convertible Preferred Stock (the “Series C-1 Preferred Stock”); (ii) an aggregate of 4,186 shares of our Series
D-1 Preferred Stock (the “Series D-1 Preferred Stock”); and (iii) warrants (the “Warrants”) to purchase up to
an aggregate of 1,613,092 shares of our common stock.
The Warrants are exercisable
commencing six months following the initial issuance date at an initial exercise price of $2.47 per share and expire five years from
the date of issuance.
On May 2, 2024, in connection
with the Purchase Agreement, we entered into a registration rights agreement with the investors (the “Registration Rights Agreement”),
pursuant to which we agreed to prepare and file with the SEC a registration statement on Form S-3 (the “Registration Statement”)
covering the resale of the shares of our common stock issuable upon conversion of the Series C-1 Preferred Stock (the “Conversion
Shares”) and upon exercise of the Warrants (the “Warrant Shares”): (i) on the later of (x) the 30th calendar
day after the closing date, or (y) the 2nd business day following the Stockholder Approval Date (as defined in the Purchase
Agreement), with respect to the initial registration statement; and (ii) on the date on which we are required to file any additional
Registration Statement pursuant to the terms of the Registration Rights Agreement with respect to any additional Registration Statements
that may be required to be filed by us (the “Filing Deadline”). Pursuant to the Registration Rights Agreement, we are required
to have the initial Registration Statement declared effective by the SEC on the earlier of: (x) the 60th calendar day
after the Filing Deadline (or the 90th calendar day after the Filing Deadline if subject to a full review by the SEC);
and (y) the 2nd business day after the date the Company is notified by the SEC that such Registration Statement will
not be reviewed. In the event that we fail to file the Registration Statement by the Filing Deadline, have it declared effective by the
Effectiveness Deadline, or the prospectus contained therein is not available for use or the investor is not otherwise able to sell its
Warrant Shares pursuant to Rule 144, we shall be required to pay the investor an amount equal to 2% of such investor’s Purchase
Price (as defined in the Purchase Agreement) on the date of such failure and on every thirty date anniversary until such failure is cured.
May 2024 Senior Note
On May 20, 2024, we
issued and sold a senior note (the “Senior Note”) to an accredited investor (the “Holder”) in the original principal
amount of $93,918.75 for a purchase price of $75,135.00, reflecting an original issue discount of $18,783.75. Unless earlier redeemed,
the Senior Note will mature on August 18, 2024 (the “Note Maturity Date”), subject to extension at the option of the Holder
in certain circumstances as provided in the Senior Note. The Senior Note bears interest at a rate of 8.5% per annum, which is compounded
each calendar month and is payable in arrears on the Note Maturity Date. The Senior Note contains certain standard events of default,
as defined in the Senior Note (each, an “Event of Default”). Upon the occurrence of an Event of Default, the interest rate
shall be increased to 18% per annum and the Holder may require the Company to redeem the Senior Note, subject to an additional 5% redemption
premium. In addition, if we sell any shares of our common stock pursuant to any equity line of credit, we are required to redeem in cash
a portion of the Senior Note equal to the lesser of: (i) the outstanding amount of the Senior Note; and (ii) 80% of 30% of such equity
line proceeds, at a redemption price calculated based upon $1.20 for each $1.00 of outstanding amount of the Senior Note. The Senior
Note also contains an exchange right, which permits the Holder, in its discretion, to exchange the Senior Note, in whole or in part,
for securities to be sold by us in a subsequent placement, subject to certain exceptions and an additional 20% premium of the amount
of the Senior Note exchanged. The Senior Note is a senior, unsecured obligation of the Company, ranking senior to all other unsecured
indebtedness of the Company.
May 2024 Private
Placement
On May 24, 2024, we
entered into a securities purchase agreement (the “Securities Purchase Agreement”) with certain accredited investors pursuant
to which we issued and sold senior notes in the aggregate principal amount of $986,379.68 (the “Notes”) maturing on August
22, 2024, which included the exchange of the previously issued Senior Note in the principal amount of $93,918.75. The Company received
cash proceeds of $775,000 from the sale of the Notes.
Upon an Event of Default
(as defined in the Notes), the Notes will bear interest at a rate of 14% per annum and the holder shall have the right to require the
Company to redeem the Notes at a redemption premium of 125%. In addition, while the Notes are outstanding, the Company is required to
utilize 100% of the proceeds from any offering of securities to redeem the Notes. Pursuant to the Securities Purchase Agreement, the
Company agreed to use commercially reasonable efforts, including the filing of a registration statement with the SEC for a public offering,
to pursue and consummate a financing transaction within 90 days of the closing date. In connection with the issuance of the Notes, the
Company issued an aggregate of 328,468 shares of its common stock (the “Commitment Shares”) as a commitment fee to the investors.
Pursuant to the Securities Purchase Agreement, the Company also agreed to file a registration statement with the SEC covering the resale
of the Commitment Shares as soon as practicable following notice from an investor, and to cause such registration statement to become
effective within 60 days following the filing thereof.
July 2024 Senior Note
On July 9, 2024 and July 12, 2024, we entered
into Securities Purchase Agreements (the “July 2024 Securities Purchase Agreements”) with an accredited investors (the “July
2024 Purchasers”) pursuant to which we issued and sold senior notes in the principal amount of $1,500,000 (the “July 2024
Note”) maturing on October 7, 2024. We received cash proceeds of $1,200,000 from the sale of the July 2024 Note.
Upon an Event of Default (as defined in the July
2024 Note), the July 2024 Note will bear interest at a rate of 14% per annum and the holder shall have the right to require us to redeem
the July 2024 Note at a redemption premium of 125%. In addition, while the July 2024 Note is outstanding, we are required to utilize
100% of the proceeds from any offering of securities to redeem the July 2024 Note. Pursuant to the July 2024 Securities Purchase Agreements,
we agreed to use commercially reasonable efforts, including the filing of a registration statement with SEC for a public offering, to
pursue and consummate a financing transaction within 90 days of the closing date. In connection with the issuance of the July 2024 Note,
we issued the July 2024 Purchasers a warrant (the “July 2024 Note Warrant”) to purchase up to 3,000,000 shares of our common
stock (the “July 2024 Warrant Shares”). Pursuant to the July 2024 Securities Purchase Agreements, we also agreed to file
a registration statement with the SEC covering the resale of the July 2024 Warrant Shares as soon as practicable following notice from
an investor, and to cause such registration statement to become effective within 60 days following the filing thereof. The July 2024
Warrant is exercisable following Stockholder Approval (as defined in the July 2024 Securities Purchase Agreement) at an initial exercise
price of $1.49 for a term of five years.
Warrant Amendment and Exercise
On July 9, 2024, we entered into an amendment
to common stock purchase warrants (the “July 2024 Warrant Amendment”) with the holder (the “Holder”) of certain
of our warrants originally issued in December 2023, April 2023, September 2022, December 2021, August 2021, and September 2020 (collectively,
the “Outstanding Warrants”), pursuant to which the Company and the Holder agreed to amend each of the Outstanding Warrants
to lower the exercise price of the Outstanding Warrants to $1.49 per share.
On July 17, 2024 the Holder exercised 836,570
warrants into 836,570 shares of the Company’s common stock.
Arrangement Agreement with Appili Therapeutics, Inc.
On April 1, 2024, we entered into an arrangement
agreement (the “Arrangement Agreement”) with Adivir, a wholly owned subsidiary of the Company and Appili Therapetics, Inc.
(“Appili”) pursuant to which Adivir will acquire all of the issued and outstanding Class A common shares of Appili (the “Appili
Shares”) on the terms and subject to the conditions set forth therein. The acquisition of the Appili Shares (the “Arrangement”)
will be completed by way of a statutory plan of arrangement under the Canada Business Corporation Act.
At the effective time of the Arrangement (the
“Arrangement Effective Time”), each Appili Share outstanding immediately prior to the Arrangement Effective Time (other than
Appili Shares held by a registered holder of Appili Shares who has validly exercised such holder’s dissent rights) will be deemed
to be assigned and transferred by the holder thereof to Adivir in exchange for: (i) $0.0467 in cash consideration per share for an aggregate
cash payment of $5,668,222 (the “Cash Consideration”); and (ii) 0.002745004 of a share of our common stock or an aggregate
of 332,876 shares (the “Consideration Shares” and together with the Cash Consideration, the “Transaction Consideration”).
In connection with the transaction, each outstanding option and warrant of Appili will be cashed-out based on the implied in-the-money
value of the Transaction Consideration, which is expected to result in an additional aggregate cash payment of approximately $341,000
(based on the number of issued and outstanding options and warrants and exchange rates as of the date of the Arrangement Agreement).
The respective obligations of each of the Company,
Adivir and Appili to consummate the closing of the Arrangement (the “Closing”) are subject to the satisfaction or waiver,
at or prior to the closing of the following conditions:
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(i) |
the Interim Order (as defined
in the Arrangement Agreement) shall have been granted on terms consistent with the Arrangement Agreement and the Interim Order shall
not have been set aside or modified in a manner unacceptable to either party; |
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(ii) |
the Arrangement Resolution
(as defined in the Arrangement Agreement) shall have been adopted by the Appili shareholders at the Appili shareholders’ meeting
in accordance with the Interim Order; |
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(iii) |
the Final Order (as defined
in the Arrangement Agreement) shall have been granted on terms consistent with the Arrangement Agreement and the Final Order shall
not have been set aside or modified in a manner unacceptable to either party; |
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(iv) |
completion of an equity
or debt financing by the Company with minimum gross proceeds of at least $20 million (the “Financing”); |
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(v) |
there shall not be any
law or order which prevents, prohibits or makes the consummation of the Arrangement illegal or otherwise prohibits the consummation
of the Arrangement or the other transaction contemplated by the Arrangement Agreement; |
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(vi) |
the issuance of the Consideration
Shares will be exempt from the registration requirements of: (A) the Securities Act of 1933, as amended (the “Securities Act”)
pursuant to Section 3(a)(10) of the Securities Act; and (B) all applicable U.S. securities laws; |
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(vii) |
the distribution of the
Consideration Shares pursuant to the Arrangement shall be exempt from the prospectus and registration requirements of applicable
securities laws ; and |
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(viii) |
the Consideration Shares
to be issued pursuant to the Arrangement shall, subject to customary conditions, have been approved for listing on Nasdaq. |
The
Company and Adivir
The
obligations of the Company and Adivir to consummate the Closing are subject to the satisfaction or waiver, at or prior to the Closing
of certain conditions, including but not limited to, the following:
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(i) |
as qualified in the Arrangement
Agreement, the representations and warranties of Appili are true and correct as of the Arrangement Effective Time as if made as at
and as of such time; |
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(ii) |
Appili shall have fulfilled
or complied in all material respects with each of its obligations, covenants and agreements contained in the Arrangement Agreement;
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(iii) |
dissent rights will not
have been exercised with respect to more than 10% of the issued and outstanding Appili Shares; |
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(iv) |
the LZH Consent Agreement
(as defined in the Arrangement Agreement) continues to remain in full force and effect and enforceable against the parties thereto
and the parties thereto have performed their respective obligations thereunder required to be completed on or before the Closing; |
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(v) |
there shall not have been
a Material Adverse Effect (as defined in the Arrangement Agreement) on Appili; and |
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(vi) |
there is no action or proceeding
pending or threatened by any governmental entity that prohibits the Company from acquiring, holding or exercising full rights of
ownership of the Appili Shares, prevents or materially delays the consummation of the Arrangement, or prohibits or restricts in any
material respect the ownership or operation of the business of the Company or Appili. |
Appili
The
obligations of Appili to consummate the Closing are subject to the satisfaction or waiver, at or prior to the Closing of the following
conditions:
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(i) |
as qualified in the Arrangement
Agreement, the representations and warranties of the Company and Adivir are true and correct as of the Arrangement Effective Time
as if made as at and as of such time; |
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(ii) |
the Company and Adivir
shall have fulfilled or complied in all material respects with each of its obligations, covenants and agreements contained in the
Arrangement Agreement; |
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(iii) |
there shall not have been
a Material Adverse Effect (as defined in the Arrangement Agreement) on the Company or Adivir; |
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(iv) |
the Third-Party Consents
(as defined in the Arrangement Agreement) shall have been obtained; |
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(v) |
there is no action or proceeding
pending or threatened by any governmental entity that cease trades, enjoins or prohibits the Company’s ability to issue the
Consideration Shares, or prevents or material delays the consummation of the Arrangement; |
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(vi) |
the Company shall have
taken steps to reconstitute the board of directors of Adivir such that it will consist of five directors as of the Effective Date,
one of whom will be the Company Nominee (as defined in the Arrangement Agreement); |
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(vii) |
the Company shall have
taken steps to have caused the Appointed Officers (as defined in the Arrangement Agreement) to be duly appointed officers of Adivir; |
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(viii) |
the Company shall satisfy
on the Arrangement Effective Date the payment in immediately available funds as directed in writing by Appili of not less than 50%
of the outstanding accounts payable of Appili, provided that in the event the Company raises gross proceeds of more than $25 million
in the Financing, any amounts raised by the Company in excess of $25 million shall be first applied by the Company to satisfy any
unpaid Closing Company Payables (as defined in the Arrangement Agreement); and |
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(ix) |
the Company shall have
deposited with the Depositary (as defined in the Arrangement Agreement) the Consideration Shares and the Cash Consideration. |
The
Arrangement Agreement may be terminated at any time prior to the consummation of the Closing by mutual written consent of the Company
and Appili.
As
further set out in the Arrangement Agreement, either the Company or Appili may also terminate the Arrangement Agreement prior to the
Effective Time if: (i) the Appili shareholders’ meeting is duly convened and held and the Arrangement Resolution (as defined in
the Arrangement Agreement) is voted on by the Appili shareholders and not approved by the Appili shareholders as required by the Interim
Order (as defined in the Arrangement Agreement); (ii) if any Law (as defined in the Arrangement Agreement) is enacted, made, issued,
rendered, enforced or amended following the date of the Arrangement Agreement that prohibits the Arrangement and such Law has become
final and non-appealable; (iii) the Arrangement Effective Time does not occur on or prior to July 31, 2024 (the “Outside Date”);
or (iv) the Financing is not completed on or before 5:00 p.m. (ET) on June 30, 2024 or such later date as the parties may in writing
agree.
The
Company may terminate the Arrangement Agreement if prior to the Effective Time: (i) a breach of any representation or warranty or failure
to perform any covenant or agreement on the part of Appili that would cause any Company or Adivir conditions to closing not to be satisfied;
(ii) prior to the approval of the Arrangement Resolution (as defined in the Arrangement Agreement) by the Appili shareholders the Appili
board of directors makes a Company Change in Recommendation (as defined in the Arrangement Agreement) or enters into a written agreement
to effect a Company Acquisition Proposal (as defined in the Arrangement Agreement); (iii) there has been a Material Adverse Effect (as
defined in the Arrangement Agreement) in respect of Appili which is incapable of being cured on or before the Outside Date; (iv) Appili
is in material breach of any of the non-solicitation or match provisions of the Arrangement Agreement; or (v) any of the conditions to
closing for the mutual benefit of the parties or for the benefit of the Company or Adivir cannot be satisfied prior to the Outside Date
and such breach or failure is incapable of being cured, provided that such breach or failure did not result from any action of the Company
or Adivir.
Appili
may terminate the Arrangement Agreement if prior to the Arrangement Effective Time: (i) a breach of any representation or warranty or
failure to perform any covenant or agreement on the part of the Company that would cause any Appili conditions to closing not to be satisfied;
(ii) prior to the approval of the Arrangement Resolution (as defined in the Arrangement Agreement) by the Appili shareholders if the
Appili board of directors makes a Company Change in Recommendation (as defined in the Arrangement Agreement) or enters into a written
agreement to effect a Company Superior Proposal (as defined in the Arrangement Agreement); (iii) the Company does not provide the Depositary
(as defined in the Arrangement Agreement) with sufficient consideration to complete the transactions contemplated by the Arrangement
Agreement; (iv) there has occurred a Material Adverse Effect (as defined in the Arrangement Agreement) in respect of the Company which
is incapable of being cured prior to the Outside Date; (v) any of the conditions to closing for the mutual benefit of the parties or
for the benefit of Appili cannot be satisfied prior to the Outside Date and such breach or failure is incapable of being cured, provided
that such breach or failure did not result from any action of Appili; or (vi) the Company does not take all actions within its control
that are necessary to remedy a default on or prior to 5:00 p.m. (ET) on the day that is 15 business days from the date of the Arrangement
Agreement.
Termination
Fee
The
Company shall be entitled to a termination fee of CDN$1,250,000 (the “Termination Fee”) in the event that:
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(i) |
the Arrangement Agreement
is terminated by Appili or the Company as a result of a Company Change in Recommendation / to enter into a Company Superior Proposal
(both as defined in the Arrangement Agreement); or |
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(ii) |
the Arrangement Agreement
is terminated by the Company as a result of breach of: (A) a representation, warranty or covenant by Appili (including Appili’s
non-solicitation covenants); (B) failure of the Appili shareholders to approve the Arrangement Resolution (as defined in the Arrangement
Agreement); or (C), the Arrangement Agreement is terminated by the Company or Appili if the Arrangement Effective Time is not prior
to the Outside Date, provided that prior to the termination of the Arrangement Agreement, a Company Acquisition Proposal (as defined
in the Arrangement Agreement) has been made to Appili or announced and within 12 months following the date of such termination: (1)
a Company Acquisition Proposal (as defined in the Arrangement Agreement) made, publicly announced or otherwise communicated to the
Appili board prior to the termination of the Arrangement Agreement is consummated; or (2) Appili enters into a definitive agreement
in respect of a Company Acquisition Proposal (as defined in the Arrangement Agreement) made, publicly announced or otherwise communicated
to the Appili board prior to the termination of the Arrangement Agreement and at any time thereafter such Company Acquisition Proposal
(as defined in the Arrangement Agreement) is consummated. |
Appili
shall be entitled to the Termination Fee in the event that:
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(i) |
the Arrangement Agreement
is terminated by the Company or Appili as a result of the failure to complete the Financing on or before June 30, 2024; |
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(ii) |
the Arrangement Agreement
is terminated by as a result of the failure to take all actions within its control that are necessary to remedy a default of the
Parent (as defined in the Arrangement Agreement) on or prior to 5:00 p.m. (ET) on the day that is 15 business days from the date
of the Arrangement Agreement; |
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(iii) |
the Arrangement Agreement
is terminated by Appili as a result of a breach of a representation, warranty or covenant by the Company or the Arrangement Agreement
is terminated by the Company or Appili if the Arrangement Effective Time is not prior to the Outside Date, provided that prior to
the termination of the Arrangement Agreement, a Parent Acquisition Proposal (as defined in the Arrangement Agreement) has been made
to the Company or announced and within 12 months following the date of such termination: (1) a Parent Acquisition Proposal (as defined
in the Arrangement Agreement) made, publicly announced or otherwise communicated to the Company board prior to the termination of
the Arrangement Agreement is consummated; or (2) the Company enters into a definitive agreement in respect of a Parent Acquisition
Proposal (as defined in the Arrangement Agreement) made, publicly announced or otherwise communicated to the Company board prior
to the termination of the Arrangement Agreement and at any time thereafter such Parent Acquisition Proposal (as defined in the Arrangement
Agreement) is consummated. |
On
July 1, 2024, the Company, Adivir and Appili entered into an Amending Agreement (the “Amending Agreement”), pursuant to which
the Parties (as defined in the Arrangement Agreement) agreed that: (i) the Outside Date (as defined in the Arrangement Agreement) would
be changed to August 30, 2024; (ii) Adivir agreed that it would convene the Company Meeting (as defined in the Arrangement Agreement)
no later than August 30, 2024, provided that Appili shall be under no obligation to convene the Company Meeting prior to the date that
is 50 days following the date that Aditxt delivers to Appili all complete Additional Financial Disclosure (as defined in the Arrangement
Agreement) required for inclusion in the Company Circular (as defined in the Arrangement Agreement); (iii) Aditxt shall use commercially
reasonable efforts to complete the Financing (as defined in the Arrangement Agreement) no later than August 30, 2024; and (iv) Aditxt
or Appili may terminate the Arrangement Agreement if the Financing is not completed by 5:00 p.m. (ET) on August 30, 2024 or such later
date as the Parties may agree in writing.
On
July 18, 2024, the Company, Adivir and Appili entered into a Second Amending Agreement (the “Second Amending Agreement”),
pursuant to which the Arrangement Agreement was further amended to provide that (i) the Outside Date will be extended to September 30,
2024, (ii) the Appili Meeting will be conducted no later than September 30, 2024, provided that Appili shall be under no obligation to
hold the Appili Meting prior to the date that is 50 days following the date that the Company delivers all complete Additional Financial
Disclosure required for inclusion in the circular; (iii) the Company shall use commercially reasonable efforts to complete the Financing
on or prior to September 15, 2024; and (iv) the Company and Appili may terminate the Arrangement Agreement if the Financing is not completed
on or before 5:00 p.m. (ET) on September 15, 2024 or such later date as the Parties may in writing agree.
Corporate
Information
We
were incorporated as a Delaware corporation on September 28, 2017. Our principal executive offices are located at 2569 Wyandotte Street,
Suite 101, Mountain View, CA 94043, and our telephone number is (650) 870-1200.
THE
OFFERING
Common Stock Offered by Us |
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Up to $35.0 million of shares of
common stock that we may sell to Seven Knots, from time to time at our sole discretion in accordance with the Purchase Agreement. |
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Common Stock to be Outstanding Immediately After this
Offering (1) |
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26,096,152 shares of common
stock, assuming the sale of 21,875,000 shares of common stock at a price of $1.60, which was the closing price of our common stock
on the Nasdaq Capital Market on October 4, 2024. The actual number of shares issued will vary depending on the sales prices in this
offering in accordance with the Purchase Agreement. |
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Use of Proceeds |
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We
expect to receive net proceeds from this offering of approximately $31.5 million, after deducting estimated offering expenses
payable by us.
We intend to use (i) $1,819,720 of the net proceeds for payments on
our outstanding Senior Notes, (ii) approximately $4,000,000 of the net proceeds for payment of obligations under the Evofem Amended and
Restated Merger Agreement, (iii) $12,480,950 for redemptions of our outstanding Convertible Preferred Stock, and (iv) and the remainder
for payments to secured creditors, accounts payable, as well as continuing operating expenses and working capital.
See
“Use of Proceeds.” |
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Risk Factors |
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Investing in our securities
involves a high degree of risk. You should read the “Risk Factors” section beginning on page S-22 of this prospectus supplement
and page 19 of the accompanying prospectus and in the documents incorporated by reference in this prospectus supplement for a discussion
of factors to consider before deciding to invest in our securities. |
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Nasdaq Capital Market symbol |
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“ADTX” |
(1) | The
number of shares of common stock to be outstanding immediately after this offering is based
on 4,221,152 shares of our common stock outstanding as of October 4, 2024, and excludes,
as of such date: |
| ● | 261,115
shares of our Common Stock issuable upon exercise of warrants, subject to vesting having a weighted average exercise price of $283.17
per share; |
| ● | 1,140
shares of our Common Stock issuable upon exercise of outstanding options under our 2017 Equity Incentive Plan and 2021 Equity Incentive
Plan or the 2017 Plan and the 2021 plan, respectively, subject to vesting; |
| ● | 621,357
shares of our Common Stock issuable upon a standard conversion of outstanding Series A-1 Convertible Preferred Stock; |
| ● | 82,821
shares of our Common Stock issuable upon a standard conversion of outstanding Series B-1 Convertible Preferred Stock; |
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● |
69,666 shares of our Common Stock issuable upon a standard
conversion of outstanding Series B-2 Convertible Preferred Stock; |
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104,557 shares of our Common Stock issuable upon a
standard conversion of outstanding Series C-1 Convertible Preferred Stock; and |
Unless
otherwise indicated, all information in this prospectus supplement assumes no exercise of options or warrants described above.
RISK FACTORS
An
investment in our securities involves a high degree of risk. Before deciding whether to invest in our securities, you should consider
carefully the risks described below, together with other information in this prospectus supplement, the accompanying prospectus and the
information and documents incorporated by reference. You should also consider the risks, uncertainties and assumptions discussed under
the heading “Risk Factors” included in our most recent Annual Report on Form 10-K and the subsequent reports that we file
with the SEC which are on file with the SEC and are incorporated herein by reference, and which may be amended, supplemented or superseded
from time to time by other reports we file with the SEC in the future. If any of these risks actually occur, our business, financial
condition, results of operations or cash flow could be adversely effected. This could cause the trading price of our common stock to
decline, resulting in a loss of all or part of your investment. The risks and uncertainties described below are not the only ones facing
us. Additional risks and uncertainties not presently known to us, or that we currently see as immaterial, may also harm our business.
Please also read carefully the section below entitled “Special Note Regarding Forward-Looking Statements.”
Risks
Related to this Offering
As
of the date of this prospectus, we have entered into several agreements and may enter into additional agreements following the date hereof,
which will limit our discretion with respect to the use of the net proceeds from this offering. Following our satisfaction of such obligations,
we will have broad discretion in the use of the net proceeds from this offering and may not use them effectively.
On
August 28, 2024, we entered into Letter Agreement with each of the Holders of our May Senior Notes, pursuant to which we agreed that
we would apply 40% of the net proceeds from any sales of common stock under this prospectus to make payments on the May Senior Notes
in the aggregate principal amount of $986,379.68 and the July Senior Notes in the aggregate principal amount of $1.5 million (collectively,
the “Senior Notes”). In addition, pursuant to the Letter Agreement, commencing on the date that the Senior Notes have been
repaid in full, we agreed to redeem all holders (each, a “Series C-1 Holder”) of our then outstanding Series C-1 Convertible
Preferred Stock which have a stated value of $10,853,000 (ratably based on the amount of Preferred Stock then held by each Series C-1
Holder) in an amount equal to, in the aggregate among all Series C-1 Holders, 40% of the net proceeds from any sales of common stock
under this prospectus.
Following
the date of this prospectus, we may enter into additional agreements that further limit our discretion with respect to the use of proceeds
hereunder. Following the satisfaction of our obligations under such agreements, our management will have broad discretion in the application
of the proceeds from this offering and could spend the proceeds in ways that do not necessarily improve our results of operations or
enhance the value of our common stock. Our failure to apply these funds effectively could have a material adverse effect on our business,
financial condition, operating results and cash flow, and could cause the price of our common stock to decline.
If
we sell shares of our common stock under the Purchase Agreement, our existing stockholders will experience immediate dilution and, as
a result, our stock price may go down.
Pursuant
to the Purchase Agreement, we have agreed to sell up to $150,000,000 of shares of our common stock at our option and subject to certain
limitations, and up to 2,250,000 shares of our common stock as consideration for Seven Knots’ commitment to enter into the Purchase
Agreement. As of the date of this prospectus supplement, we have sold [*] shares of our common stock under the Purchase Agreement. For
additional details on this financing arrangement, please refer to “Seven Knots Transaction” and “Plan of Distribution”
located elsewhere in this prospectus. The sale of shares of our common stock pursuant to the Purchase Agreement will have a dilutive
impact on our existing stockholders. Seven Knots may resell some or all of the shares we issue to it under the Purchase Agreement and
such sales could cause the market price of our common stock to decline, which decline could be significant.
Risks
Related to Our Financial Position and Need for Capital
Our
financial situation creates doubt whether we will continue as a going concern.
We
were incorporated in September 2017 and have a limited operating history and our business is subject to all the risks inherent in the
establishment of a new business enterprise. Our likelihood of success must be considered in light of the problems, expenses, difficulties,
complications and delays frequently encountered in connection with development and expansion of a new business enterprise. Since inception,
we have incurred losses and expect to continue to operate at a net loss for at least the next several years as we commence our research
and development efforts, conduct clinical trials, and develop manufacturing, sales, marketing, and distribution capabilities. Our net
loss attributable to common stockholders for the years ended December 31, 2023 and 2022 was $32,700,710 and $27,687,553, respectively,
and our accumulated deficit as of December 31, 2023 was $127,741,072. Our
net loss for the six months ended June 30, 2024 and 2023 was $22,492,573 and $11,666,724, respectively,
and our accumulated deficit as of June 30, 2024 was $150,024,555. There can be no assurance that the products under development by us
will be approved for sale in the U.S. or elsewhere or that we will successfully close any of our pending M&A transactions. Furthermore,
there can be no assurance that if our products are approved, they will be successfully commercialized, and the extent of our future losses
and the timing of our profitability are highly uncertain. In addition, we may not be able to successfully integrate any businesses that
we have acquired or plan to acquire. If we are unable to achieve profitability, we may be unable to continue our operations. There can
be no assurances that we will be able to achieve a level of revenues adequate to generate sufficient cash flow from operations or additional
financing through private placements, public offerings and/or bank financing necessary to support our working capital requirements. To
the extent that funds generated from any private placements, public offerings and/or bank financing are insufficient, we will have to
raise additional working capital. No assurance can be given that additional financing will be available, or if available, will be on
acceptable terms. These conditions raise substantial doubt about our ability to continue as a going concern. If adequate working capital
is not available, we may be forced to discontinue operations, which would cause investors to lose their entire investment.
If
we fail to obtain the capital necessary to fund our operations, we will be unable to continue or complete our product development and
you will likely lose your entire investment.
We
will need to continue to seek capital from time to time to continue development of our lead drug candidate beyond our initial combined
Phase I/Iia clinical trial and to acquire and develop other product candidates. Once approved for commercialization, we cannot provide
any assurances that any revenues it may generate in the future will be sufficient to fund our ongoing operations.
Our
business or operations may change in a manner that would consume available funds more rapidly than anticipated and substantial additional
funding may be required to maintain operations, fund expansion, develop new or enhance products, acquire complementary products, business
or technologies, or otherwise respond to competitive pressures and opportunities, such as a change in the regulatory environment or a
change in preferred treatment modalities. In addition, we may need to accelerate the growth of our sales capabilities and distribution
beyond what is currently envisioned, and this would require additional capital. However, we may not be able to secure funding when we
need it or on favorable terms. We may not be able to raise sufficient funds to commercialize the product candidates we intend to develop.
If
we cannot raise adequate funds to satisfy our capital requirements, we will have to delay, scale back or eliminate our research and development
activities, clinical studies, or future operations. We may also be required to obtain funds through arrangements with collaborators,
which arrangements may require us to relinquish rights to certain technologies or products that we otherwise would not consider relinquishing,
including rights to future product candidates or certain major geographic markets. This could result in sharing revenues which we might
otherwise retain for ourselves. Any of these actions may harm our business, financial condition, and results of operations.
The
amount of capital we may need depends on many factors, including the progress, timing and scope of our product development programs;
the progress, timing and scope of our preclinical studies and clinical trials; the time and cost necessary to obtain regulatory approvals;
the time and cost necessary to further develop manufacturing processes and arrange for contract manufacturing; our ability to enter into
and maintain collaborative, licensing and other commercial relationships; and our partners’ commitment of time and resources to
the development and commercialization of our products.
Our
obligations to certain of our creditors are secured by security interests in our assets, so if we default on those obligations, our creditors
could foreclose on some or all of our assets.
Our
obligations to certain of our creditors are secured by security interests in our assets. As of the date of this prospectus supplement,
approximately $7.8 million was owed to such secured creditors. Under such agreements, we are required to pay $277,800 on a weekly
basis to such creditors. If we default on our obligations under these agreements, our secured creditors could foreclose on their
security interests and liquidate some or all of these assets, which would harm our financial condition and results of operations and
would require us to reduce or cease operations and possibly seek Bankruptcy Protection.
We
are currently over 90 days past due on a significant amount of vendor obligations. We may not be able to refinance, extend or repay our
substantial indebtedness owed to our secured and unsecured lenders, which would have a material adverse effect on our financial condition
and ability to continue as a going concern.
As
of the date of this prospectus, we have approximately $19 million in accounts payable and accrued expenses with approximately $9.6 million
that is over 90 days past due. If we are unable to repay these amounts, as well as our existing debt obligations at maturity, and we
are otherwise unable to extend the maturity dates or refinance these obligations, we would be in default. We cannot provide any assurances
that we will be able to raise the necessary amount of capital to repay these obligations or that we will be able to extend the maturity
dates or otherwise refinance these obligations. Upon a default, our secured lenders would have the right to exercise their rights and
remedies to collect, which would include foreclosing on our assets. Accordingly, a default would have a material adverse effect on our
business, and we would likely be forced to seek bankruptcy protection.
In
the event we pursue Bankruptcy Protection, we will be subject to the risks and uncertainties associated with such proceedings.
In
the event we file for relief under the United States Bankruptcy Code, our operations, our ability to develop and execute our business
plan and our continuation as a going concern will be subject to the risks and uncertainties associated with bankruptcy proceedings, including,
among others: our ability to execute, confirm and consummate a plan of reorganization; the additional, significant costs of bankruptcy
proceedings and related fees; our ability to obtain sufficient financing to allow us to emerge from bankruptcy and execute our business
plan post-emergence, and our ability to comply with terms and conditions of that financing; our ability to continue our operations in
the ordinary course; our ability to maintain our relationships with our consumers, business partners, counterparties, employees and other
third parties; our ability to obtain, maintain or renew contracts that are critical to our operations on reasonably acceptable terms
and conditions; our ability to attract, motivate and retain key employees; the ability of third parties to use certain limited safe harbor
provisions of the United States Bankruptcy Code to terminate contracts without first seeking Bankruptcy Court approval; the ability of
third parties to force us to into Chapter 7 proceedings rather than Chapter 11 proceedings and the actions and decisions of our stakeholders
and other third parties who have interests in our bankruptcy proceedings that may be inconsistent with our operational and strategic
plans. Any delays in our bankruptcy proceedings would increase the risks of our being unable to reorganize our business and emerge from
bankruptcy proceedings and may increase our costs associated with the bankruptcy process or result in prolonged operational disruption
for us. Also, we would need the prior approval of the bankruptcy court for transactions outside the ordinary course of business during
the course of any bankruptcy proceedings, which may limit our ability to respond timely to certain events or take advantage of certain
opportunities. Because of the risks and uncertainties associated with any bankruptcy proceedings, we cannot accurately predict or quantify
the ultimate impact of events that could occur during any such proceedings. There can be no guarantees that if we seek Bankruptcy Protection
we will emerge from Bankruptcy Protection as a going concern or that holders of our common stock will receive any recovery from any bankruptcy
proceedings.
In
the event we are unable to pursue Bankruptcy Protection under Chapter 11 of the United States Bankruptcy Code, or, if pursued, successfully
emerge from such proceedings, it may be necessary to pursue Bankruptcy Protection under Chapter 7 of the United States Bankruptcy Code
for all or a part of our businesses.
In
the event we are unable to pursue Bankruptcy Protection under Chapter 11 of the United States Bankruptcy Code, or, if pursued, successfully
emerge from such proceedings, it may be necessary for us to pursue Bankruptcy Protection under Chapter 7 of the United States Bankruptcy
Code for all or a part of our businesses. In such event, a Chapter 7 trustee would be appointed or elected to liquidate our assets for
distribution in accordance with the priorities established by the United States Bankruptcy Code. We believe that liquidation under Chapter
7 would result in significantly smaller distributions being made to our stakeholders than those we might obtain under Chapter 11 primarily
because of the likelihood that the assets would have to be sold or otherwise disposed of in a distressed fashion over a short period
of time rather than in a controlled manner and as a going concern.
We
will need to raise substantial additional capital, which may not be available on acceptable terms, or at all. Failure to obtain this
necessary capital when needed may force us to delay, limit or terminate our product development efforts or cease operations.
We
do not expect that our current cash position will be sufficient to fund our current operations for the next 12 months. We
also do not presently have sufficient cash to fund certain obligations under our Merger Agreement with Evofem or our Arrangement Agreement
with Appili, which will require cash payments in the amounts of approximately $19.2 million and approximately $17 million, respectively.
In addition, we are required to complete an equity or debt financing with minimum gross proceeds of at least $20 million in order to
close the transactions contemplated under our Arrangement Agreement with Appili. Our operating plan may change because of
many factors currently unknown to us, and we may need to seek additional funds sooner than planned, through public or private equity
or debt financings, government or other third-party funding, marketing and distribution arrangements and other collaborations, strategic
alliances and licensing arrangements or a combination of these approaches. In any event, we will require additional capital to obtain
regulatory approval for, and to commercialize, our product candidates. Raising funds in the current economic environment may present
additional challenges. Even if we believe we have sufficient funds for our current or future operating plans, we may seek additional
capital if market conditions are favorable or if we have specific strategic considerations.
Any
additional fundraising efforts may divert our management from their day-to-day activities, which may adversely affect our ability to
develop and commercialize our product candidates. In addition, we cannot guarantee that future financing will be available in sufficient
amounts or on terms acceptable to us, if at all. Moreover, the terms of any financing may adversely affect the holdings or the rights
of our stockholders and the issuance of additional securities, whether equity or debt, by us, or the possibility of such issuance, may
cause the market price of our shares to decline. The sale of additional equity or convertible securities may dilute our existing stockholders.
The incurrence of indebtedness would result in increased fixed payment obligations, and we may be required to agree to certain restrictive
covenants, such as limitations on our ability to incur additional debt, limitations on our ability to acquire, sell or license intellectual
property rights and other operating restrictions that could adversely impact our ability to conduct our business. We could also be required
to seek funds through arrangements with collaborative partners or otherwise at an earlier stage than otherwise would be desirable and
we may be required to relinquish rights to some of our technologies or product candidates or otherwise agree to terms unfavorable to
us, any of which may have a material adverse effect on our business, operating results and prospects.
If
we are unable to obtain funding on a timely basis, we may be required to significantly curtail, delay, or discontinue one or more of
our research or development programs or the commercialization of any product candidate or be unable to expand our operations or otherwise
capitalize on our business opportunities, as desired, which could materially affect our business, financial condition and results of
operations.
We
may not be able to effect the transactions contemplated under the Merger Agreement with Evofem or the Arrangement Agreement with Appili
.. If we are unable to do so, we will incur substantial costs associated with withdrawing from the transaction.
In
connection with the Merger Agreement with Evofem and the Arrangement Agreement with Appili, we have incurred substantial costs planning
and negotiating the transactions. These costs include, but are not limited to, costs associated with employing and retaining third-party
advisors who perform financial, auditing and legal services required before we were able to enter into such agreements and which services
will continue to be utilized as we seek to complete such transactions. If, for whatever reason, such transactions fail to close, we will
still be responsible for these costs, which could adversely affect our liquidity and financial results.
Risks
Related to This Offering and Our Common Stock
Our
management team may invest or spend the proceeds raised in this offering in ways with which you may not agree or which may not yield
a significant return.
Our
management will have broad discretion over the use of proceeds from this offering and could spend the proceeds in ways that do not
improve our results of operations or enhance the value of our common stock. The failure by management to apply these funds effectively
could result in financial losses that could have a material adverse effect on our business, cause the price of our common stock to decline,
and delay the development of our product candidates.
A
significant number of shares of our common stock may be issued and sold upon the exercise of outstanding options, warrants, and upon
the conversion of the Company’s convertible preferred stock.
As
of June 30, 2024, there were 45,572 shares of common stock issuable under outstanding options, 6,887,581 shares of common stock issuable
upon exercise of outstanding warrants at various exercise prices and approximately 17,286,209 shares of common stock reserved for issuance
upon conversion of outstanding convertible preferred stock. During the three months ended September 30, 2024, we have issued an aggregate
of 7,292,672 shares of common stock upon conversion of outstanding convertible preferred stock. To the extent that holders of existing
options, warrants or convertible preferred stock sell the shares of common stock issued upon the exercise of options or warrants or conversion
of the convertible preferred stock, the market price of our common stock may decrease due to the additional selling pressure in the market.
The risk of dilution from issuances of shares of common stock underlying existing options, warrants and convertible preferred
stock may cause shareholders to sell their common stock, which could further decline in the market price.
If
you purchase securities in this offering, you may also experience future dilution as a result of future equity offerings.
We
expect that significant additional capital will be needed in the future to continue our planned operations, including research and development,
increased marketing, hiring new personnel, commercializing our products, and continuing activities as an operating public company. To
the extent we raise additional capital by issuing equity securities, our shareholders may experience substantial dilution. We may sell
common stock, convertible securities or other equity securities in one or more transactions at prices and in a manner we determine from
time to time. If we sell common stock, convertible securities or other equity securities in more than one transaction, investors may
be materially diluted by subsequent sales. Such sales may also result in material dilution to our existing shareholders, and new investors
could gain rights superior to our existing shareholders.
We
do not intend to pay cash dividends on our shares of common stock so any returns will be limited to the value of our shares.
We
have never paid or declared any cash dividends on our common stock, and we do not anticipate paying any cash dividends on our common
stock in the foreseeable future. We currently anticipate that we will retain future earnings for the development, operation and expansion
of our business. Any future determination to pay dividends will be at the discretion of our board of directors and will depend upon a
number of factors, including our results of operations, financial condition, future prospects, contractual restrictions, restrictions
imposed by applicable law and other factors that our board of directors deems relevant. Therefore, any return to shareholders will be
limited to the increase, if any, of our share price.
We
received a written notice from Nasdaq that we have failed to comply with certain listing requirements of the Nasdaq Stock Market, which
could result in our Common Stock being delisted from the Nasdaq Stock Market.
On
May 23, 2023, we received written notice from Nasdaq that, based upon the stockholders equity reported by the Company in its Form
10-Q for the period ended June 30, 2023, and as of June 30, 2023, the Company was no longer in compliance with Nasdaq Listing Rule 5550(b)(1),
which requires a company to maintain a minimum of $2,500,000 in stockholders’ equity, a market value of listed securities of at
least $35 million, or net income from continuing operations of $500,000 in the most recently completed fiscal year or in two of the three
most recently completed fiscal years (the “Continued Listing Requirements”). The May notification letter further provided
that the Company has 45 calendar days, or until July 7, 2023, to submit a plan to regain compliance and if the plan is accepted by Nasdaq,
an extension of up to 180 calendar days, or until November 19, 2023 to evidence compliance. On June 22, 2023, we received a letter
from Nasdaq notifying the Company that it has failed to maintain compliance with the minimum bid price rule in Nasdaq Listing Rule 5550(a)(2)
(the “Minimum Bid Price Rule”) as the closing price of Company’s common stock has remained below $1.00 for over 30
consecutive trading days. On June 29, 2023, we submitted an appeal to Nasdaq, which stays the delisting and suspension of our securities
pending the decision of the Nasdaq Hearings Panel (the “Panel”). At the hearing, which was held on August 31, 2023, which
represented the tenth trading day that the closing of the Company’s common stock was above $1.00 per share. At the hearing, the
Company also presented its plans to regain compliance with the Equity Rule to the Panel. In addition, on September 15, 2023, the Company
received a written notice form Nasdaq that it no longer meets the minimum 500,000 publicly held shares requirement for The Nasdaq Capital
Market and it no longer complies with Nasdaq Listing Rule 5550(a)(4) (the “Public Float Rule”). The September notification
letter stated that the Panel will consider this matter in their decision regarding the Company’s continued listing on The Nasdaq
Capital Market.
On
September 29, 2023, the Company received a written notice from Nasdaq that the Panel had granted the Company an exception through December
26, 2023, to allow the Company to complete its compliance with the Equity Rule. The October notification letter also confirmed that the
Company had demonstrated compliance with the Minimum Bid Price Rule and granted the Company an exception through December 26, 2023 to
allow the Company to demonstrate compliance with the Public Float Rule. On December 29, 2023, the Company received written notice from
Nasdaq that we had regained compliance with the Stockholders’ Equity Rule, but will be subject to a Mandatory Panel Monitor for
a period of one year.
If
we are delisted from Nasdaq, but obtain a substitute listing for our common stock, it will likely be on a market with less liquidity,
and therefore experience potentially more price volatility than experienced on Nasdaq. Stockholders may not be able to sell their shares
of common stock on any such substitute market in the quantities, at the times, or at the prices that could potentially be available on
a more liquid trading market. As a result of these factors, if our common stock is delisted from Nasdaq, the value and liquidity of our
common stock, warrants and pre-funded warrants would likely be significantly adversely affected. A delisting of our common stock from
Nasdaq could also adversely affect our ability to obtain financing for our operations and/or result in a loss of confidence by investors,
employees and/or business partners.
SPECIAL NOTE
REGARDING FORWARD-LOOKING STATEMENTS
This
prospectus supplement and the documents incorporated by reference herein contain forward-looking statements that are based on current
management expectations. Statements other than statements of historical fact included in this prospectus supplement, including statements
about us and the future growth and anticipated operating results and cash expenditures, are forward-looking statements within the meaning
of Section 27A of the Securities Act of 1933 (“Securities Act”), as amended, and Section 21E of the Securities Exchange Act
of 1934, as amended (“Exchange Act”). When used in this prospectus supplement the words “anticipate,” “objective,”
“may,” “might,” “should,” “could,” “can,” “intend,” “expect,”
“believe,” “estimate,” “predict,” “potential,” “plan” or the negative of
these and similar expressions identify forward-looking statements. These statements reflect our current views with respect to uncertain
future events and are based on imprecise estimates and assumptions and subject to risk and uncertainties. Given these uncertainties,
you should not place undue reliance on these forward-looking statements. While we believe our plans, intentions and expectations reflected
in those forward-looking statements are reasonable, these plans, intentions or expectations may not be achieved. Our actual results,
performance or achievements could differ materially from those contemplated, expressed or implied by the forward-looking statements contained
in, or incorporated by reference into, this prospectus supplement for a variety of reasons.
We
urge investors to review carefully risks contained in the section of this prospectus entitled “Risk Factors” above as well
as other risks and factors identified from time to time in our SEC filings in evaluating the forward-looking statements contained in
this prospectus supplement. We caution investors not to place significant reliance on forward-looking statements contained in this document;
such statements need to be evaluated in light of all the information contained herein.
All
forward-looking statements attributable to us or persons acting on our behalf are expressly qualified in their entirety by the risk factors
and other cautionary statements set forth, or incorporated by reference, in this prospectus supplement. Except as required by law, we
are under no obligation, and we do not intend, to update any forward-looking statement, whether as result of new information, future
events or otherwise.
DIVIDEND POLICY
We
have never paid or declared any cash dividends on our common stock, and we do not anticipate paying any cash dividends on our common
stock in the foreseeable future. We intend to retain all available funds and any future earnings to fund the development and expansion
of our business. Any future determination to pay dividends will be at the discretion of our board of directors and will depend upon a
number of factors, including our results of operations, financial condition, future prospects, contractual restrictions, restrictions
imposed by applicable law and other factors that our board of directors deems relevant.
USE
OF PROCEEDS
We
may receive up to $35.0 million in aggregate gross proceeds under the Purchase Agreement from any sales we make to Seven Knots pursuant
to the Purchase Agreement after the date of this prospectus supplement. We estimate that the net proceeds to us from the sale of our
common stock to Seven Knots pursuant to the Purchase Agreement will be up to $[*], assuming that we sell the full amount of our common
stock that we have the right, but not the obligation, to sell to Seven Knots under the Purchase Agreement, and after other estimated
fees and expenses. We may sell fewer than all of the shares offered by this prospectus supplement, in which case our net offering proceeds
will be less. Because we are not obligated to sell any shares of our common stock under the Purchase Agreement, the actual total offering
amount and proceeds to us, if any, are not determinable at this time. See “Plan of Distribution” elsewhere in this prospectus
supplement for more information.
We intend to use (i) $1,819,720 of the net proceeds
for payments on our outstanding Senior Notes, (ii) approximately $4,000,000 of the net proceeds for payment of obligations under the Evofem
Amended and Restated Merger Agreement, (iii) $12,480,950 for redemptions of our outstanding Convertible Preferred Stock, and (iv) and
the remainder for payments to secured creditors, accounts payable, as well as continuing operating expenses and working capital.
This
expected use of net proceeds from this offering and our existing cash represents our intentions based upon our current plans and business
conditions, which could change in the future as our plans and business conditions evolve. The amounts and timing of our actual expenditures
may vary significantly depending on numerous factors. As a result, our management will retain broad discretion over the allocation of
the net proceeds from this offering.
As
of the date of this prospectus supplement, we cannot predict with certainty all the uses for the net proceeds to be received upon the
completion of this offering or the amounts we will spend on the uses set forth above.
SEVEN
KNOTS TRANSACTION
On
May 2, 2024, we entered into, pursuant to the Purchase Agreement with Seven Knots, pursuant to which Seven Knots has agreed to purchase
from us, from time to time, in our sole discretion, from and after the date of this prospectus and until the termination of the Purchase
Agreement in accordance with the terms thereof, shares of our common stock having a total maximum aggregate purchase price of $150,000,000
(the “Purchase Shares”), upon the terms and subject to the conditions and limitations set forth in the Purchase Agreement.
In
connection with the Purchase Agreement, we also entered into a Registration Rights Agreement with Seven Knots (the “Registration
Rights Agreement”), pursuant to which we agreed to file a registration statement with the Securities and Exchange Commission covering
the resale of the shares of common stock issued to Seven Knots pursuant to the Purchase Agreement (the “Registration Statement”)
by the later of (i) the 30th calendar day following the closing date, and (ii) the second business day following the
date on which we obtain Stockholder Approval (as defined below).
We
may, from time to time and at our sole discretion, direct Seven Knots to purchase shares of our common stock upon the satisfaction
of certain conditions set forth in the Purchase Agreement at a purchase price per share based on the market price of our common stock
at the time of sale as computed under the Purchase Agreement. There is no upper limit on the price per share that Seven Knots could
be obligated to pay for common stock under the Purchase Agreement. We will control the timing and amount of any sales of our common stock
to Seven Knots, and Seven Knots has no right to require us to sell any shares to it under the Purchase Agreement. Actual
sales of shares of common stock to Seven Knots under the Purchase Agreement will depend on a variety of factors to be determined
by us from time to time, including (among others) market conditions, the trading price of our common stock and determinations by us as
to available and appropriate sources of funding for us and our operations. Seven Knots may not assign or transfer its rights
and obligations under the Purchase Agreement.
Under
the applicable Nasdaq rules, we were prohibited from issuing to Seven Knots under the Purchase Agreement more than 332,876
shares of common stock, which number of shares is equal to 19.99% of the shares of the common stock outstanding immediately prior to
the execution of the Purchase Agreement (the “Exchange Cap”), until we obtained stockholder approval to issue shares
of common stock in excess of the Exchange Cap in accordance with applicable Nasdaq rules (“Stockholder Approval”), or (ii)
the average price per share paid by Seven Knots for all of the shares of common stock that we direct Seven Knots to
purchase from us pursuant to the Purchase Agreement, if any, equals or exceeds the official closing sale price on the Nasdaq Capital
Market immediately preceding the delivery of the applicable purchase notice to Seven Knots and (B) the average of the closing sale prices
of the our common stock on the Nasdaq Capital market for the five business days immediately preceding the delivery of such purchase notice.
We obtained Stockholder Approval at our 2024 annual meeting of stockholders on August 7, 2024.
In
all cases, we may not issue or sell any shares of common stock to Seven Knots under the Purchase Agreement which, when aggregated
with all other shares of our common stock then beneficially owned by Seven Knots and its affiliates, would result in Seven
Knots beneficially owning more than 4.99% of the outstanding shares of our common stock.
Purchase
of Shares under the Purchase Agreement
Fixed
Purchases
Under
the Purchase Agreement, on any business day selected by us where the closing sale price of our common stock equals or exceeds $1.00 per
share, which has been waived by Seven Knots in accordance with the terms of the
Purchase Agreement, (and provided that all shares subject to all prior Fixed Purchases, VWAP
Purchases and Additional VWAP Purchases, have theretofore been properly delivered to Seven Knots in accordance with the Purchase Agreement),
we may direct Seven Knots to purchase, in what we refer to as a Fixed Purchase, up to the lesser of 100,000 shares or $200,000. The purchase
price per share for each such Fixed Purchase will be equal to the lesser of 95% of:
|
● |
the daily volume weighted
average price of our common stock for the five trading days immediately preceding the Fixed Purchase date; or |
|
● |
the lowest trading price
of a share of our common stock on the applicable Fixed Purchase date. |
VWAP
Purchases
In
addition to Fixed Purchases, we also have the right to direct Seven Knots, on any business day on which we have properly submitted to
Seven Knots a Fixed Purchase notice for the maximum amount of shares we are then permitted to sell in a Fixed Purchase (and provided
that all shares subject to all prior Fixed Purchases, VWAP Purchases and Additional VWAP Purchases have theretofore been properly delivered
to Seven Knots), to purchase an additional amount of our common stock, which we refer to as a VWAP Purchase, of up to the lesser of:
|
● |
300% of the number of shares
to be purchased pursuant to such Fixed Purchase; and |
|
● |
30% of the trading volume
in our Common Stock during the applicable VWAP Purchase period on the applicable VWAP Purchase date |
The
purchase price per share for each such Accelerated Purchase will be equal to the lesser of 95% of:
|
● |
the closing sale price
of the common stock on the applicable VWAP Purchase date; and |
|
● |
the volume weighted average
price during the applicable VWAP Purchase period. |
Additional
VWAP Purchases
We
also have the right to direct Seven Knots on a VWAP Purchase date for an Additional VWAP Purchase (and provided that all of the Purchase
Shares subject to all prior Fixed Purchases, VWAP Purchases and Additional VWAP Purchases, including those that have occurred earlier
on the same trading day have theretofore been properly delivered to Seven Knots in accordance with the Purchase Agreement), to purchase
additional shares of our common stock in another VWAP Purchase, which we refer to as an Additional VWAP Purchase, on the same business
day, which shall not exceed $2 million in the aggregate for such VWAP Purchase and Additional VWAP Purchase, of up to the lesser of:
|
● |
300% of the number of shares
purchased pursuant to the applicable corresponding Fixed Purchase; and |
|
● |
30% of the aggregate shares
of our common stock traded during the period on the applicable Additional VWAP Purchase date. |
The
purchase price per share for each such Additional VWAP Purchase will be equal to the lower of:
|
● |
95% of the volume-weighted
average price of our common stock for the applicable Additional VWAP Purchase period; and |
|
● |
the closing sales price
of our common stock on such Additional VWAP Purchase date. |
Termination
Rights
We
have the right to terminate the Purchase Agreement at any time after the Commencement Date (as defined in the Purchase Agreement), at
no cost or penalty, upon three trading days’ prior written notice to Seven Knots. The Company and the Investor may also
agree to terminate the Purchase Agreement by mutual written consent, provided that no termination of the Purchase Agreement will be effective
during the pendency of any purchase that has not then fully settled in accordance with the Purchase Agreement. Neither the Company nor the
Investor may assign or transfer the Company’s respective rights and obligations under the Purchase Agreement.
Effect
of Performance of the Purchase Agreement on our Stockholders
All
shares registered in this offering that may be issued and sold by us to Seven Knots under the Purchase Agreement are expected to be freely
tradable. Shares registered in this offering may be sold over the term of the Purchase Agreement. The sale by Seven Knots of a significant
amount of shares registered in this offering at any given time could cause the market price of our common stock to decline and to be
highly volatile. Sales of our common stock to Seven Knots, if any, will depend upon market conditions and other factors to be determined
by us, in our sole discretion. We may ultimately decide to sell to Seven Knots all, some or none of the shares of our common stock that
may be available for us to sell pursuant to the Purchase Agreement. If and when we do sell shares to Seven Knots, after Seven Knots has
acquired the shares, Seven Knots may resell all, some or none of those shares at any time or from time to time in its discretion. Therefore,
sales to Seven Knots by us under the Purchase Agreement may result in substantial dilution to the interests of other holders of our common
stock. In addition, if we sell a substantial number of shares to Seven Knots under the Purchase Agreement, or if investors expect that
we will do so, the actual sales of shares or the mere existence of our arrangement with Seven Knots may make it more difficult for us
to sell equity or equity-related securities in the future at a time and at a price that we might otherwise wish to effect such sales.
However, we have the right to control the timing and amount of any additional sales of our shares to Seven Knots and the Purchase Agreement
may be terminated by us at any time at our discretion without any cost to us.
Pursuant
to the terms of the Purchase Agreement, we have the right, but not the obligation, to direct Seven Knots to purchase up to $150,000,000
of our common stock, exclusive of any shares of common stock that we may issue as consideration for its commitment to purchase shares
of our common stock under the Purchase Agreement. As noted above and as of the date of this prospectus we have not issued or sold any
shares of common stock to Seven Knots under the Purchase Agreement. The Purchase Agreement prohibits us from issuing or selling to Seven
Knots under the Purchase Agreement shares of our common stock if those shares, when aggregated with all other shares of our common stock
then beneficially owned by Seven Knots, would exceed 4.99% of the outstanding shares of our common stock.
DILUTION
If
you purchase securities in the offering, you will experience immediate dilution to the extent of the difference between the assumed public
offering price per share of $1.60 per share of common stock, which represents the closing price of our common stock on the Nasdaq Capital
Market on October 4, 2024 and our as-adjusted pro forma net tangible book value per share immediately after the offering. Net tangible
book value per share is equal to the amount of our total tangible assets, less total liabilities, divided by the number of outstanding
shares of our common stock. As of June 30, 2024, our net tangible book value was approximately $6.3 million, or approximately $127.11
per share.
Our
pro forma net tangible book value on June 30, 2024 was approximately $15.7 million, or $3.73 per share, after giving effect to (i) the
issuance of notes of $1.5 million (ii) the issuance of an aggregate of 20,917 shares of our common stock upon the exercise of outstanding
warrants at a reduced exercise price of $59.60 per share resulting in gross proceeds of approximately $1.2 million, (iii) the issuance
of an aggregate of 6,468 shares of our common stock upon the conversion of outstanding Series A-1 Convertible Preferred Stock (iv) the
issuance of common stock and exercise of prefunded warrants of 28,255 shares upon the closing of a $1.2 million registered direct offering,
(v) the issuance of 767,922 common shares in exchange for the conversion of Series B-1 Convertible Preferred shares, (vi) the issuance
of a note of $0.9 million, (vii) the issuance of an aggregate of 3,347,535 shares of our common stock upon the sales of $6.9 million
via the Company’s equity line of credit, (viii) the repayment of certain outstanding notes of $0.7 million, and (ix) the issuance
of 212 shares in connection with rounding of lots as a result of the reverse stock split. “Net tangible book value” is total
assets minus the sum of liabilities and intangible assets. “Net tangible book value per share” is net tangible book value
divided by the total number of shares outstanding.
The
following table illustrates this per-share of our common stock dilution:
Effective offering price per share
of common stock | |
| | | |
$ | 1.60 | |
Pro forma net tangible book value per share as of June
30, 2024 | |
| | | |
$ | 3.72 | |
Decrease in pro forma net
tangible book value per share attributable to this offering | |
$ | | | |
| (1.78 | ) |
As adjusted pro forma net
tangible book value per share as of June 30, 2024 after giving effect to this offering | |
$ | 1.94 | | |
| | |
Anti-Dilution per share to
the new investor in this offering | |
$ | (0.34 | ) | |
| | |
The
information above assumes for illustrative purposes that an aggregate of 21,875,000 shares of our common stock were sold during the term
of the offering at a sales price of $1.60 per share, which is the closing price of our common stock as reported on Nasdaq on October
4, for aggregate gross proceeds of $35,000,000.
The
total number of shares of our common stock reflected in the discussion and tables above is based on 49,843 shares
of our common stock outstanding as of June 30, 2024, but excludes the following as of such date:
|
● |
172,190 shares
of our Common Stock issuable upon exercise of warrants, subject to vesting having a weighted average exercise price of $425.20 per
share; |
|
● |
1,140 shares of our Common
Stock issuable upon exercise of outstanding options under our 2017 Equity Incentive Plan and 2021 Equity Incentive Plan or the 2017
Plan and the 2021 plan, respectively, subject to vesting; |
|
● |
125,451 shares of our Common
Stock issuable upon a standard conversion of outstanding Series A-1 Convertible Preferred Stock; |
|
● |
36,946 shares of our Common
Stock issuable upon a standard conversion of outstanding Series B-1 Convertible Preferred Stock; |
|
● |
13,934 shares of our Common
Stock issuable upon a standard conversion of outstanding Series B-2 Convertible Preferred Stock; and |
|
● |
40,328 shares of our Common
Stock issuable upon a standard conversion of outstanding Series C-1 Convertible Preferred Stock. |
PLAN
OF DISTRIBUTION
Pursuant
to this prospectus supplement and the accompanying prospectus, we are offering up to $35.0 million in shares of our common stock pursuant
to the Purchase Agreement. This prospectus supplement and the accompanying prospectus also cover the resale of these shares by Seven
Knots to the public.
The
shares may be sold or distributed from time to time by Seven Knots directly to one or more purchasers or through brokers, dealers, or
underwriters who may act solely as agents at market prices prevailing at the time of sale, at prices related to the prevailing market
prices, at negotiated prices, or at fixed prices, which may be changed. The sale of our common stock offered by this prospectus could
be effected in one or more of the following methods:
|
● |
ordinary brokers’
transactions; |
|
● |
transactions involving
cross or block trades; |
|
● |
through brokers, dealers,
or underwriters who may act solely as agents; |
|
● |
“at the market”
into an existing market for our common stock; |
|
● |
in other ways not involving
market makers or established business markets, including direct sales to purchasers or sales effected through agents; |
|
● |
in privately negotiated
transactions; or |
|
● |
any combination of the
foregoing. |
In
order to comply with the securities laws of certain states, if applicable, the shares may be sold only through registered or licensed
brokers or dealers. In addition, in certain states, the shares may not be sold unless they have been registered or qualified for sale
in the state or an exemption from the state’s registration or qualification requirement is available and complied with.
Seven
Knots, LLC is an “underwriter” within the meaning of Section 2(a)(11) of the Securities Act.
Seven
Knots has informed us that it intends to use one or more registered broker-dealers to effectuate all sales, if any, of our common stock
that it has acquired and may in the future acquire from us pursuant to the Purchase Agreement. Such sales will be made at prices and
at terms then prevailing or at prices related to the then current market price. Each such registered broker-dealer will be an underwriter
within the meaning of Section 2(a)(11) of the Securities Act. Seven Knots has informed us that each such broker-dealer will receive commissions
from Seven Knots that will not exceed customary brokerage commissions.
Brokers,
dealers, underwriters or agents participating in the distribution of our common stock offered by this prospectus may receive compensation
in the form of commissions, discounts, or concessions from the purchasers, for whom the broker-dealers may act as agent, of the shares
sold by the selling shareholder through this prospectus. The compensation paid to any such particular broker-dealer by any such purchasers
of our common stock sold by the selling shareholder may be less than or in excess of customary commissions. Neither we nor the selling
shareholder can presently estimate the amount of compensation that any agent will receive from any purchasers of our common stock sold
by the selling shareholder.
We
know of no existing arrangements between Seven Knots or any other shareholder, broker, dealer, underwriter or agent relating to the sale
or distribution of our common stock offered by this prospectus.
Seven
Knots has represented to us that at no time prior to the date of the Purchase Agreement has Seven Knots or its agents, representatives
or affiliates engaged in or effected, in any manner whatsoever, directly or indirectly, any short sale (as such term is defined in Rule
200 of Regulation SHO of the Exchange Act) of our common stock or any hedging transaction, which establishes a net short position with
respect to our common stock. Seven Knots has agreed that during the term of the Purchase Agreement, neither Seven Knots, nor any of its
agents, representatives or affiliates will enter into or effect, directly or indirectly, any of the foregoing transactions.
We
have advised the selling shareholder that it is required to comply with Regulation M promulgated under the Exchange Act. With certain
exceptions, Regulation M precludes the selling shareholder, any affiliated purchasers, and any broker-dealer or other person who participates
in the distribution from bidding for or purchasing, or attempting to induce any person to bid for or purchase any security which is the
subject of the distribution until the entire distribution is complete. Regulation M also prohibits any bids or purchases made in order
to stabilize the price of a security in connection with the distribution of that security. All of the foregoing may affect the marketability
of the securities offered by this prospectus.
This
offering will terminate on the date that all of our common stock offered by this prospectus have been sold by the selling shareholder.
Our
common stock is currently listed on The Nasdaq Capital Market under the symbol “ADTX”.
LEGAL MATTERS
The
validity of the shares of our common stock offered hereby will be passed upon for us by Sheppard, Mullin, Richter & Hampton LLP,
New York, New York.
EXPERTS
dbbmckennon,
an independent registered public accounting firm, has audited our financial statements included in our Annual Report on Form 10-K for
the year ended December 31, 2023, as set forth in their report, which includes an explanatory paragraph as to our ability to continue
as a going concern, dated April 16, 2024, which is incorporated by reference in this prospectus and elsewhere in the registration statement,
given on the authority of such firm as experts in accounting and auditing.
The
consolidated financial statements of Evofem Biosciences, Inc. as of and for the year ended December 31, 2023 incorporated by reference
in this Registration Statement of Aditxt, Inc., have been audited by BPM LLP, an independent registered public accounting firm, as stated
in their report (which contains an explanatory paragraph relating to substantial doubt about the ability of Evofem Biosciences, Inc.
to continue as a going concern as described in Note 1 to the consolidated financial statements) which is also incorporated by reference
herein. Such consolidated financial statements have been so incorporated by reliance herein in reliance on the report of such firm given
on the authority of said firm as experts in auditing and accounting.
The
financial statements of Evofem Biosciences, Inc. and subsidiaries as of December 31, 2022, and for the year ended December 31, 2022,
incorporated by reference in this Prospectus, have been audited by Deloitte & Touche LLP, an independent registered public accounting
firm, as stated in their report. Such financial statements are incorporated by reference in reliance upon the report of such firm given
their authority as experts in accounting and auditing.
The
audited historical financial statements of Appili Therapeutics Inc. which appears in Aditxt, Inc.’s Current Report on Form 8-K
filed on August 1, 2024 have been so incorporated in reliance on the report of PricewaterhouseCoopers LLP, independent auditors, given
on the authority of said firm as experts in auditing and accounting.
WHERE YOU
CAN FIND MORE INFORMATION
We
have filed with the SEC a registration statement on Form S-3 under the Securities Act, of which this prospectus supplement forms
a part. The rules and regulations of the SEC allow us to omit from this prospectus supplement and the accompanying prospectus certain
information included in the registration statement. For further information about us and the securities we are offering under this prospectus
supplement, you should refer to the registration statement and the exhibits and schedules filed with the registration statement. With
respect to the statements contained in this prospectus supplement and the accompanying prospectus regarding the contents of any agreement
or any other document, in each instance, the statement is qualified in all respects by the complete text of the agreement or document,
a copy of which has been filed as an exhibit to the registration statement.
We
file reports, proxy statements and other information with the SEC. The SEC maintains a website that contains reports, proxy and information
statements and other information regarding issuers that file electronically with the SEC. The address of the SEC’s website is www.sec.gov.
We
make available free of charge on or through our website at https://www.aditxt.com/investor-relations/sec-filings/, our Annual
Reports on Form 10-K, Quarterly Reports on Form 10-Q, Current Reports on Form 8-K and amendments to those reports filed or furnished
pursuant to Section 13(a) or 15(d) of the Exchange Act, as soon as reasonably practicable after we electronically file such material
with or otherwise furnish it to the SEC. The information on, or accessible through, our website is not part of, and is not incorporated
into, this prospectus supplement or the accompanying prospectus and should not be considered part of this prospectus supplement or the
accompanying prospectus. You may also request a copy of these filings, at no cost, by writing or telephoning us at: 2569 Wyandotte St.,
Suite 101, Mountain View, CA 94043, (650) 870-1200.
INCORPORATION
OF DOCUMENTS BY REFERENCE
The
SEC allows us to incorporate by reference into this prospectus supplement much of the information we file with the SEC, which means that
we can disclose important information to you by referring you to those publicly available documents. The information that we incorporate
by reference is considered to be part of this prospectus supplement and the accompanying prospectus. Because we are incorporating by
reference future filings with the SEC, this prospectus supplement and the accompanying prospectus are continually updated and those future
filings may modify or supersede some of the information included or incorporated in this prospectus supplement and the accompanying prospectus.
This means that you must look at all of the SEC filings that we incorporate by reference to determine if any of the statements in this
prospectus supplement or the accompanying prospectus or in any document previously incorporated by reference have been modified or superseded.
This prospectus supplement and the accompanying prospectus incorporate by reference the documents listed below and any future filings
we make with the SEC under Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act (in each case, other than those documents or the portions
of those documents not deemed to be filed) until the offering of the securities under the registration statement
is terminated or completed:
|
● |
Current
Reports on Form 8-K, filed with the SEC on January 2, 2024, January 5, 2024, January 5, 2024, January 9, 2024, January 19, 2024,
January 30, 2024, January 30, 2024, February 2, 2024, February 6, 2024, February 9, 2024, February 15, 2024, February 16, 2024, February 21, 2024, February 22, 2024, February 29, 2024, March 1, 2024, March 4, 2024, March 11, 2024, April 4, 2024 (as amended on August 1, 2024), April 12, 2024, May 3, 2024 (as amended May 3, 2024), May 7, 2024, May 8, 2024, May 13, 2024, May 22, 2023, May 28, 2024,
June 12, 2024, June 21, 2024, June 25, 2024, July 8, 2024, July 9, 2024, July 18, 2024, July 22, 2024, August 1, 2024 (originally
filed on December 12, 2023), August 8, 2024, August 8, 2024, August 9, 2024, August 13, 2024, August 21, 2024, August 28, 2024, September 5, 2024 (originally filed on December 12, 2023), September 5, 2024 (originally filed on April 4, 2024), September 6, 2024, September 23, 2024, and October 3, 2024; |
|
● |
Annual
Report on Form 10-K for the year ended December 31, 2023 filed with the SEC on April 16, 2024; |
|
● |
Quarterly
Report on Form 10-Q for the three months ended March 31, 2024 filed with the SEC on May 20, 2024; |
|
● |
Quarterly
Report on Form 10-Q for the six months ended June 30, 2024 filed with the SEC on August 19, 2024; |
|
● |
Proxy
Statement on Schedule 14A filed on July 5, 2024; and |
|
● |
the
description of our common stock and our preferred stock contained in our Registration Statement on Form 8-A12B/A filed with
the SEC on June 17, 2020, and any amendments or reports filed updating such description. |
You
may request, and we will provide you with, a copy of these filings, at no cost, by calling us at (650) 870-1200 or by writing to us at
the following address:
Aditxt,
Inc.
2569
Wyandotte Street, Suite 101
Mountain
View, CA 94043
PROSPECTUS
Aditxt,
Inc.
Common Stock
Preferred Stock
Debt Securities
Warrants
Rights
Units
We may offer and sell, from
time to time in one or more offerings, any combination of common stock, preferred stock, debt securities, warrants to purchase common
stock, preferred stock or debt securities, or any combination of the foregoing, either individually or as units comprised of one or more
of the other securities, having an aggregate initial offering price not exceeding $100,000,000.
This prospectus provides
a general description of the securities we may offer. Each time we sell a particular class or series of securities, we will provide specific
terms of the securities offered in a supplement to this prospectus. The prospectus supplement and any related free writing prospectus
may also add, update or change information contained in this prospectus. We may also authorize one or more free writing prospectuses
to be provided to you in connection with these offerings. You should read carefully this prospectus, the applicable prospectus supplement
and any related free writing prospectus, as well as any documents incorporated by reference herein or therein before you invest in any
of our securities.
The specific terms of any
securities to be offered, and the specific manner in which they may be offered, will be described in one or more supplements to this
prospectus. This prospectus may not be used to consummate sales of any of these securities unless it is accompanied by a prospectus supplement.
Before investing, you should carefully read this prospectus and any related prospectus supplement.
Our common stock is presently
listed on The Nasdaq Capital Market under the symbol “ADTX.” On July 31, 2024, the last reported sale price of our common
stock was $1.19 per share. The applicable prospectus supplement will contain information, where applicable, as to any other listing on
The Nasdaq Capital Market or any securities market or other exchange of the securities, if any, covered by the prospectus supplement.
Prospective purchasers of our securities are urged to obtain current information as to the market prices of our securities, where applicable
These securities may be sold
directly by us, through dealers or agents designated from time to time, to or through underwriters, dealers, or through a combination
of these methods on a continuous or delayed basis. See “Plan of Distribution” in this prospectus. We may also describe
the plan of distribution for any particular offering of our securities in a prospectus supplement. If any agents, underwriters or dealers
are involved in the sale of any securities in respect of which this prospectus is being delivered, we will disclose their names and the
nature of our arrangements with them in a prospectus supplement. The price to the public of such securities and the net proceeds we expect
to receive from any such sale will also be included in a prospectus supplement.
Investing in our
securities involves various risks. See “Risk Factors” beginning on page 19 for more information on
these risks. Additional risks will be described in the related prospectus supplements under the heading “Risk
Factors.” You should review that section of the related prospectus supplements for a discussion of matters that
investors in our securities should consider.
Neither the U.S. Securities
and Exchange Commission nor any state securities commission has approved or disapproved of these securities, or passed upon the adequacy
or accuracy of this prospectus or any accompanying prospectus supplement. Any representation to the contrary is a criminal offense.
The date of this prospectus is August 6, 2024.
TABLE OF CONTENTS
ABOUT THIS PROSPECTUS
This
prospectus is part of a registration statement that we filed with the U.S. Securities and Exchange Commission (“SEC”), using
a “shelf” registration process. Under this shelf registration statement, we may sell from time to time in one or more offerings
of common stock and preferred stock, various series of debt securities and/or warrants to purchase any of such securities, either individually
or as units comprised of a combination of one or more of the other securities in one or more offerings up to a total dollar amount of
$100,000,000. This prospectus provides you with a general description of the securities we may offer. Each time we sell any type or series
of securities under this prospectus, we will provide a prospectus supplement that will contain more specific information about the terms
of that offering.
This
prospectus does not contain all of the information included in the registration statement. For a more complete understanding of the offering
of the securities, you should refer to the registration statement, including its exhibits. We may add, update or change in a prospectus
supplement or free writing prospectus any of the information contained in this prospectus or in the documents we have incorporated by
reference into this prospectus. We may also authorize one or more free writing prospectuses to be provided to you that may contain material
information relating to these offerings. This prospectus, together with the applicable prospectus supplement, any related free writing
prospectus and the documents incorporated by reference into this prospectus and the applicable prospectus supplement, will include all
material information relating to the applicable offering. You should carefully read both this prospectus and the applicable prospectus
supplement and any related free writing prospectus, together with the additional information described under “Where You Can
Find More Information,” before buying any of the securities being offered.
We
have not authorized any dealer, agent or other person to give any information or to make any representation other than those contained
or incorporated by reference in this prospectus, any accompanying prospectus supplement or any related free writing prospectus that we
may authorize to be provided to you. You must not rely upon any information or representation not contained or incorporated by reference
in this prospectus or an accompanying prospectus supplement, or any related free writing prospectus that we may authorize to be provided
to you. This prospectus, the accompanying prospectus supplement and any related free writing prospectus, if any, do not constitute an
offer to sell or the solicitation of an offer to buy any securities other than the registered securities to which they relate, nor do
this prospectus, the accompanying prospectus supplement or any related free writing prospectus, if any, constitute an offer to sell or
the solicitation of an offer to buy securities in any jurisdiction to any person to whom it is unlawful to make such offer or solicitation
in such jurisdiction. You should not assume that the information contained in this prospectus, any applicable prospectus supplement or
any related free writing prospectus is accurate on any date subsequent to the date set forth on the front of the document or that any
information we have incorporated by reference is correct on any date subsequent to the date of the document incorporated by reference
(as our business, financial condition, results of operations and prospects may have changed since that date), even though this prospectus,
any applicable prospectus supplement or any related free writing prospectus is delivered or securities are sold on a later date.
We
further note that the representations, warranties and covenants made by us in any agreement that is filed as an exhibit to any document
that is incorporated by reference in this prospectus were made solely for the benefit of the parties to such agreement, including, in
some cases, for the purpose of allocating risk among the parties to such agreements, and should not be deemed to be a representation,
warranty or covenant to you. Moreover, such representations, warranties or covenants were accurate only as of the date when made. Accordingly,
such representations, warranties and covenants should not be relied on as accurately representing the current state of our affairs.
This
prospectus may not be used to consummate sales of our securities, unless it is accompanied by a prospectus supplement. To the extent
there are inconsistencies between any prospectus supplement, this prospectus and any documents incorporated by reference, the document
with the most recent date will control.
As
permitted by the rules and regulations of the SEC, the registration statement, of which this prospectus forms a part, includes additional
information not contained in this prospectus. You may read the registration statement and the other reports we file with the SEC at the
SEC’s web site or at the SEC’s offices described below under the heading “Where You Can Find More Information.”
Company References
In
this prospectus “the Company,” “we,” “us,” and “our” refer to Aditxt, Inc., a Delaware
corporation, and its subsidiaries, unless the context otherwise requires.
BUSINESS
Overview and Mission
We believe the world needs—and
deserves—a new approach to innovating that harnesses the power of large groups of stakeholders who work together to ensure that
the most promising innovations make it into the hands of people who need them most.
We were incorporated in the
State of Delaware on September 28, 2017, and our headquarters are in Mountain View, California. The company was founded with a mission
of bringing stakeholders together, to transform promising innovations into products and services that could address some of the most
challenging needs. The socialization of innovation through engaging stakeholders in every aspect of it, is key to transforming more innovations,
more rapidly, and more efficiently.
At inception, the first innovation
we took on was an immune modulation technology titled ADI/Adimune with a focus on prolonging life and enhancing life quality of patients
that have undergone organ transplants. Since then, we expanded our portfolio of innovations, and we continue to evaluate a variety of
promising health innovations.
Our Model
We are not focused on a single
idea or a single molecule. We believe that it is about making sure the right innovation is made possible. Our business model has three
main components as follows:
|
(1) |
Securing an Innovation: Our process begins with identifying and securing
innovations through licensing or acquisition of an innovation asset. Assets come from a variety of sources including research institutions,
government agencies, and private organizations. |
|
(2) |
Growing an Innovation: Once an innovation is secured, we surround it
with activation resources that take a systemized approach to bringing that idea to life. Our activation resources include innovation,
operations, commercialization, finance, content and engagement, personnel, and administration. |
|
(3) |
Monetizing an Innovation: Our goal is for each innovation to become
commercial-stage and financially and operationally self-sustainable, to create shareholder value. |
We engage various stakeholders
for each of our programs on every level. This includes identifying researchers and research institution partners, such as Stanford University;
leading health institutions to get critical trials underway, such as Mayo Clinic; manufacturing partners who enable us to take innovations
from preclinical to clinical; municipalities and governments, such as the city of Richmond and the state of Virginia and public health
agencies who work with us to launch our program, Pearsanta’s laboratory; and thousands of shareholders around the globe. We seek
to enable promising innovation to become purposeful products that have the power to change lives.
Our Value Proposition
We believe that far too often,
promising treatment or technology does not reach commercialization due to lack of expertise, key resources, or efficiency. As a result,
potentially life-changing and lifesaving treatments are not available to the individuals who so desperately need them.
We seek to bring the holistic
concept of an efficient, socialized ecosystem for advancing and accelerating innovations. Our process: We seek to license or acquire
promising innovations. We will then form and build out a subsidiary around each innovation and support the subsidiaries through innovation,
operation, commercialization, content and engagement, finance, personnel, and administration to thrive and grow as a successful, monetizable
business.
Since
our inception, we have built infrastructure consisting of innovation, operation, commercialization,
content and engagement, finance, personnel, and administration, to support the rapid transformation
of untapped innovations. Each of the main components of our infrastructure has established
global access to partnerships with industry leaders, top-rated research and medical institutions,
universities, manufacturing and distribution companies, and critical infrastructure such
as Clinical Laboratory Improvement Amendments-certified state-of-the art labs and Good Manufacturing
Practices manufacturing.
The Shifting Landscape of Innovation
Innovation
in general, and health innovations specifically, require significant resources. The convergence of biotech, high-tech, and media offers
new possibilities for accelerating breakthrough innovations faster and more efficiently. This approach reflects our mission of “Making
Promising Innovations Possible, Together”.
People deserve access to
innovative solutions that have never been more within reach. We believe the best idea, best product and the best solution will come from
creating an ecosystem where all stakeholders, such as vendors, customers, municipalities, and shareholders contribute. When we disrupt
the way we’re innovating, through our collaborative model, we believe we can move faster and more efficiently to activate viable
solutions that have the potential to make a measurable impact.
Our Growth Strategy
We believe that the era of
precision and personalized medicine is here and that people around the globe would benefit from health diagnostics and treatments that
more accurately pinpoint the problems and more precisely treat the condition. In addition to our current programs, Adimune and Pearsanta,
we look to bring in future health innovations in the areas of software and AI, medical devices, therapeutics, and other technologies
that take a fundamentally different approach to health because they prioritize personalized precision medicine, timely disease root cause
analysis, and targeted treatments.
Year over year, we plan to
continue building our infrastructure and securing more personalized and precision health innovations that align with our mission. These
opportunities may come in different forms such as intellectual property, an early-stage company, or a late-stage company. We will continue
to scale our systemized approach to the innovation process, making large-scale automation and enterprise systems available to our portfolio
companies at every stage of their growth. Specifically, certain subsidiaries will need to grow through further M&A activities, operational
infrastructure implementation, and development or acquisition of critical technologies.
Our Team
Aditxt is led by an entrepreneurial
team with passion for transforming promising innovations into successful businesses. Our leadership come from a variety of different
industries, with collective expertise in founding startup innovation companies, developing and marketing biopharmaceutical and diagnostic
products, designing clinical trials, manufacturing, and management of private and public companies. We have deep experience in identifying
and accessing promising health innovations and developing them into products and services with the ability to scale. We understand the
capital markets, both public and private, as well as M&A and facilitating complex IPOs.
The following are profiles
of three subsidiaries we have formed, including the terms of the intellectual property licenses that have been sublicensed from Aditxt
to help build each of the businesses.
OUR
PROGRAMS
We are a commercial-stage
company with a mission of bringing stakeholders together, to transform promising innovations into products and services that could address
some of the most challenging needs. Our current focus spans five critical areas: immune health, precision health, population health,
women’s health, and neurologic health. We are developing a robust portfolio and pipeline of products at various stages of development
and also regularly seek to acquire complementary assets and products through acquisitions and other strategic transactions. Set forth
below is a summary of our current programs.
Program | |
Focus | |
Product | |
Indication | |
Development | | |
Pre-Launch | | |
Commercial | |
Adimune | |
Immune Health | |
ADI-100 | |
Psoriasis | |
X | | |
| | |
| |
Adimune | |
Immune Health | |
ADI-100 | |
Type 1 diabetes | |
X | | |
| | |
| |
Adimune | |
Immune Health | |
ADI-100 | |
Stiff-persons syndrome | |
X | | |
| | |
| |
Adimune | |
Immune Health | |
ADI-100 | |
Skin allografting | |
X | | |
| | |
| |
Pearsanta | |
Precision Health | |
AditxtScore Ab | |
COVID-19 | |
X | | |
X | | |
X | |
Pearsanta | |
Precision Health | |
AditxtScore NAb | |
COVID-19 | |
X | | |
X | | |
X | |
Pearsanta | |
Precision Health | |
MET | |
Endometriosis | |
X | | |
X | | |
| |
Pearsanta | |
Precision Health | |
MPT | |
Prostate CA | |
X | | |
X | | |
| |
Pearsanta | |
Precision Health | |
UTI | |
Advanced UTI | |
X | | |
| | |
| |
Pearsanta | |
Precision Health | |
MOT | |
Ovarian CA | |
X | | |
| | |
| |
Pearsanta | |
Precision Health | |
PLT | |
Lung CA | |
X | | |
| | |
| |
Pearsanta | |
Precision Health | |
LFA-RVP | |
Flu A/B, COVID | |
X | | |
| | |
| |
Pearsanta | |
Precision Health | |
AditxtScore T1D | |
Type 1 diabetes | |
X | | |
| | |
| |
Pearsanta | |
Precision Health | |
AditxtScore CNS | |
NMO & MOGAD | |
X | | |
| | |
| |
Brain Scientific | |
Neuro Health | |
NeuroCap/NeuroEEG | |
Epilepsy/TBI/Dementia | |
X | | |
X | | |
| |
ADIMUNE
Adimune™, Inc. (“Adimune”)
is focused on leading our immune modulation therapeutic programs. Adimune’s proprietary immune modulation product Apoptotic DNA
Immunotherapy™, or ADI-100™, utilizes a novel approach that mimics how our bodies naturally induce tolerance to our own tissues.
It includes two DNA molecules designed to deliver signals to induce tolerance. ADI-100 has been successfully tested in several preclinical
models (e.g., skin grafting, psoriasis, type 1 diabetes, multiple sclerosis).
In May 2023, Adimune entered
into a clinical trial agreement with Mayo Clinic to advance clinical studies targeting autoimmune diseases of the central nervous system
(“CNS”) with the initial focus on the rare, but debilitating, autoimmune disease Stiff Person Syndrome (“SPS”).
According to the National Organization of Rare Diseases, the exact incidence and prevalence of SPS is unknown; however, one estimate
places the incidence at approximately one in one million individuals in the general population.
Pending approval by the International
Review Board, a human trial for SPS is expected to commence in the first half of 2024 with enrollment of 10 to 15 patients, some of whom
may also have type 1 diabetes. ADI-100™ will initially be tested for safety and efficacy. ADI-100™ is designed
to tolerize against an antigen known as glutamic acid decarboxylase (“GAD”), which is implicated in type-1 diabetes, psoriasis,
and many autoimmune diseases of the CNS.
Background
The
discovery of immunosuppressive (anti-rejection and monoclonal) drugs over 40 years ago enabled life-saving organ transplantation procedures
and blocking of unwanted immune responses in autoimmune diseases. However, immune suppression leads to significant undesirable side effects,
such as increased susceptibility to life-threatening infections and cancers, because it indiscriminately and broadly suppresses immune
function throughout the body. While the use of these drugs has been justifiable because they prevent or delay organ rejection, their
use for treatment of autoimmune diseases and allergies may not be acceptable because of the aforementioned side effects. Furthermore,
often transplanted organs ultimately fail despite the use of immune suppression, and about 40% of transplanted organs survive no more
than five years.
Through
Aditxt, Adimune has the right to use to the exclusive worldwide license for commercializing ADI™ nucleic acid-based
technology (which is currently at the pre-clinical stage) from Loma Linda University (“LLU”). ADI™ uses a novel approach
that mimics the way the body naturally induces tolerance to our own tissues (“therapeutically induced immune tolerance”).
While immune suppression requires continuous administration to prevent rejection of a transplanted organ, induction of tolerance has
the potential to retrain the immune system to accept the organ for more extended periods of time. ADI™ may allow patients
to live with transplanted organs with significantly reduced immune suppression. ADI™ is a technology platform which
we believe can be engineered to address a wide variety of indications.
Advantages
ADI™
is a nucleic acid-based technology (e.g., DNA-based), which we believe selectively suppresses only those immune cells involved
in attacking or rejecting self and transplanted tissues and organs. It does so by tapping into the body’s natural cell turnover
process (i.e., apoptosis) to retrain the immune system to stop unwanted attacks on self or transplanted tissues. Apoptosis is a natural
process used by the body to clear dying cells and to allow recognition and tolerance to self-tissues. ADI™ triggers
this process by enabling immune system cells to recognize the targeted tissues as “self.” Conceptually, it is designed to
retrain the immune system to accept the tissues, similar to how natural apoptosis reminds our immune system to tolerate to our own “self”
tissues.
While
various groups have promoted tolerance through cell therapies and ex vivo manipulation of patient cells (i.e., takes
place outside the body), to our knowledge, we will be unique in our approach of using in-body induction of apoptosis to promote tolerance
to specific tissues. In addition, ADI™ treatment itself will not require additional hospitalization but only an
injection of minute amounts of the therapeutic drug into the skin.
Moreover,
preclinical studies have demonstrated that ADI™ treatment significantly and substantially prolongs graft survival, in
addition to successfully “reversing” other established immune-mediated inflammatory processes.
License Agreement with Loma Linda University
On March 15, 2018, we entered
into a License Agreement with LLU (the “LLU License Agreement”), which was subsequently amended on July 1, 2020. Pursuant
to the LLU License Agreement, we obtained the exclusive royalty-bearing worldwide license to all intellectual property, including patents,
technical information, trade secrets, proprietary rights, technology, know-how, data, formulas, drawings, and specifications, owned or
controlled by LLU and/or any of its affiliates and related to therapy for immune-mediated inflammatory diseases (the ADI™ technology).
In consideration for the LLU License Agreement, we issued 25,000 shares of common stock to LLU.
PEARSANTA
Pearsanta, Inc. (Pearsanta”)
is focused on precision health, leveraging cutting-edge diagnostic technologies for disease detection and management. We believe that
timely and personalized testing enables far more informed treatment decisions. Pearsanta aims to empower consumers to monitor their health
more proactively, offering a complete picture of someone’s dynamic health status, including genetic makeup and medication response.
Central to Pearsanta’s innovation are the AditxtScore™ technology platform and the Mitomic® Technology Platform, which
we acquired from MDNA Life Sciences, Inc. (“MDNA”) in January 2024.
Licensed Technologies – AditxtScore™
We
have sublicensed to Pearsanta, an exclusive worldwide sublicense for commercializing the AditxtScore™ technology, which
provides a personalized, comprehensive immune system profile. AditxtScore™ is intended to detect individual immune responses
to viruses, bacteria, peptides, drugs, supplements, bone marrow and solid organ transplants, and cancer. It also has broad applicability
to many other agents of clinical interest impacting the immune system, including those not yet identified, such as emerging infectious
agents.
AditxtScore™
is being developed to enable individuals and their healthcare providers to understand, manage, and monitor their immune profiles
and to stay informed about attacks on or by their immune system. AditxtScore can also assist the medical community and individuals by
anticipating the immune system’s potential response to viruses, bacteria, allergens, and foreign tissues such as transplanted organs.
This technology may be able to serve as a warning signal, thereby allowing for more time to respond appropriately. Its advantages include
providing simple, rapid, accurate, high throughput assays that can be multiplexed to determine the immune status concerning several factors
simultaneously in approximately 3-16 hours. Additionally, it can evaluate and differentiate between distinct types of cellular and humoral
immune responses (e.g., T and B cells and other cell types). It also provides for simultaneous monitoring of cell activation and levels
of cytokine release (i.e., cytokine storms).
We
are actively involved in the regulatory approval process for AditxtScore™
assays for clinical use and securing manufacturing, marketing, and distribution partnerships
for application in various markets. To obtain regulatory approval to use AditxtScore™
as a clinical assay, we have conducted validation studies to evaluate its performance
in detecting antibodies and plan to continue conducting additional validation studies for
new applications in autoimmune diseases.
Advantages
The
sophistication of the AditxtScore technology includes the following:
|
● |
greater sensitivity/specificity; |
|
● |
20-fold higher dynamic range, greatly reducing signal to noise compared
to conventional assays; |
|
● |
ability to customize assays and multiplex a large number of analytes
with speed and efficiency; |
|
● |
ability to test for cellular immune responses (i.e., T and B cells
and cytokines); and |
|
● |
proprietary reporting algorithm. |
License Agreement with Leland Stanford Junior University (“Stanford”)
On February 3, 2020, we entered
into an exclusive license agreement (the “February 2020 License Agreement”) with Stanford regarding a patent concerning a
method for detection and measurement of specific cellular responses. Pursuant to the February 2020 License Agreement, we received an
exclusive worldwide license to Stanford’s patent with regard to use, import, offer, and sale of Licensed Products (as defined in
the February 2020 License Agreement). The license to the patented technology is exclusive, including the right to sublicense, beginning
on the effective date of the agreement, and ending when the patent expires. Under the exclusivity agreement, we acknowledged that Stanford
had already granted a non-exclusive license in the Nonexclusive Field of Use, under the Licensed Patents in the Licensed Field of Use
in the Licensed Territory (as those terms are defined in the February 2020 License Agreement). However, Stanford agreed not to grant
further licenses under the Licensed Patents in the Licensed Field of Use in the Licensed Territory. On December 29, 2021, we entered
into an amendment to the February 2020 License Agreement which extended our exclusive right to license the technology deployed in AditxtScore™ and
securing worldwide exclusivity in all fields of use of the licensed technology.
Mitomic® Technology Platform
In January 2024, we acquired
the assets comprising our mitomic technology platform from MDNA. This platform seeks to harness the unique properties of mitochondrial
DNA (“mtDNA”) to detect disease through non-invasive, blood-based liquid biopsies.
The Mitomic® Technology
Platform is designed to identify specific mutations in mtDNA indicative of various diseases. Due to its high mutation rate and cell persistence,
mitochondrial DNA is an excellent biomarker for early disease detection. This platform allows for the rapid and accurate identification
of disease-associated biomarkers, which can significantly enhance early diagnosis and treatment.
Key Products Under Development at Time of
Acquisition:
Mitomic® Endometriosis
Test (MET™):
| ● | Purpose:
To provide an accurate and non-invasive diagnosis of endometriosis, a condition that affects
approximately 1 in 10 women of reproductive age worldwide. |
| ● | Clinical
Validation: MET™ has demonstrated high accuracy in predicting surgical outcomes in
women suspected of having endometriosis. The test has shown significant promise in reducing
the diagnostic delay, which averages around ten years. |
| ● | Impact:
Early and precise diagnosis through MET™ can lead to timely and effective treatment,
significantly improving patient outcomes and quality of life |
Mitomic®
Prostate Test (MPT™):
| ● | Purpose:
To enhance the detection of clinically significant prostate cancer, reducing reliance on
PSA testing, which often results in false positives and over-diagnosis. |
| ● | Clinical
Validation: MPT™ has shown the ability to predict prostate cancer accurately, distinguishing
between aggressive and non-aggressive forms. This specificity is crucial in guiding treatment
decisions and reducing unnecessary interventions. |
| ● | Impact:
MPT™ aims to improve patient outcomes by ensuring that only those with clinically significant
prostate cancer receive treatment, thereby avoiding the side effects of unnecessary procedures. |
To
date, our primary focus with respect to the Mitomic Technology Platform has been the integration of such assets into our business.
Our initial plans for the Mitomic Technology Platform are to complete product development, manufacturing and clinical validation of the
MET™ and the MPT™.:
BRAIN SCIENTIFIC
We do not believe that precision
health is limited to biochemical or immunological testing data. We continue to seek to identify platform technologies that enhance our
portfolio of product lines that meet our vision of improving health by providing better access to care and developing innovative therapies.
We believe that neurological testing also provides important information regarding brain health. We identified certain assets that were
then subject to an insolvency proceeding that we believe have the potential to expand the use of EEG recordings more easily and make
them more accessible in decentralized locations. We believe that these assets also have the potential to gather and process data obtained
from various media (e.g. electroencephalogram (“EEG”) recordings, MRI and other imaging media) to assist with more complex
diagnoses.
In January 2024, we entered
an Assignment and Assumption Agreement (the “Brain Assignment Agreement”) with the agent (the “Agent”) of certain
secured creditors (the “Brain Creditors”) of Brain Scientific, Inc., a Nevada corporation (“Brain Scientific”)
and Philip J. von Kahle (the “Brain Seller”), as assignee of Brain Scientific and certain affiliated entities (collectively,
the “Brain Companies”) under an assignment for the benefit of creditors pursuant to Chapter 727 of the Florida Statutes.
Pursuant to the Brain Assignment Agreement, the Agent assigned its rights under that certain Asset Purchase and Settlement Agreement
dated October 31, 2023 between the Brain Seller and the Agent (the “Brain Asset Purchase Agreement”) to the Company in consideration
for the issuance by the Company of an aggregate of 6,000 shares of our newly designated Series B-1 Convertible Preferred Stock.
In connection with the Brain Assignment Agreement, we entered into a patent assignment with the Brain Seller, pursuant to which the Brain
Seller assigned all of its rights, titles and interests in certain patents and patent applications that were previously held by the Brain
Companies to us. The intellectual property acquired relates to certain neurology products and motion products.
Neurology Products
The neurology products were
designed to simplify the completion of EEG recordings in a more ambulatory setting. The NeuroCap™ and NeuroEEG™
products, which were 510K FDA cleared pre-launch ready, are focused on providing efficient tools to the EEG medical market. These
technologies were designed to allow a miniature, wireless, clinical device capable of recording an EEG and provide the data to medical
staff without the need to use bulky hardware or a neurology technician for the placement of the cap.
The NeuroCap™
is an FDA-cleared disposable, soft layered cap with an integrated electrode circuit designed to address conventional EEG systems’
existing problems. The silver embedded wiring is pre-gelled, requiring no preparation of the skin before application. NeuroCap™
makes it possible for medical staff of all levels to perform EEG tests, without having to laboriously apply electrodes one-by-one
or spend considerable time cleaning an EEG headset after each use.
The NeuroCap™
works in parallel with the NeuroEEG™ amplifier device to carry out EEG tests. The NeuroCap™ can
also work with other EEG devices. The NeuroCap™’s electrode placement follows standard alignment pursuant to the
international 10-20 system. The acquisition of electrical brain activity is carried out by non-invasive pre-gelled passive Ag/AgCl scalp
(cutaneous) electrodes, ensuring maximum comfort for the wearer.
The motion products are small
piezoelectric motors which are designed for and expected to have valuable and beneficial uses as motors within medical devices and devices
outside of the MedTech industry. We believe that these technologies will help us expand our technology focused products.
ADIVIR
Formed
in April of 2023, Adivir™, Inc. (“Adivir”) is Aditxt’s most recently formed wholly owned subsidiary, dedicated
to the clinical and commercial development efforts of innovative antiviral products, which have the potential to address a wide range
of infectious diseases, including those that currently lack viable treatment options.
Background
On
April 18, 2023, we entered into an Asset Purchase Agreement (the “Asset Purchase Agreement”) with Cellvera Global Holdings
LLC (“Cellvera Global”), Cellvera Holdings Ltd. (“BVI Holdco”), Cellvera, Ltd. (“Cellvera Ltd.”),
Cellvera Development LLC (“Cellvera Development” and together with Cellvera Global, BVI Holdco, Cellvera Ltd. and Cellvera
Development (the “Sellers”), AiPharma Group Ltd. (“Seller Owner” and collectively with the Sellers, “Cellvera”),
and the legal representative of Cellvera, pursuant to which, the Company will purchase Cellvera’s 50% ownership interest in G Response
Aid FZE (“GRA”), certain other intellectual property and all goodwill related thereto (the “Acquired Assets”). Unless
expressly stated otherwise herein, capitalized terms used but not defined herein have the meanings ascribed to them in the Asset Purchase
Agreement. Pursuant to the Asset Purchase Agreement, the consideration for the Acquired Assets consists of (A) $24.5 million, comprised
of: (i) the forgiveness of the Company’s $14.5 million loan to Cellvera Global, and (ii) approximately $10 million in cash, and
(B) future revenue sharing payments for a term of seven years. GRA holds an exclusive, worldwide license for the antiviral medication,
Avigan® 200mg, excluding Japan, China and Russia. The other 50% interest in GRA is held by Agility, Inc. (“Agility”).
Additionally,
upon the closing, the share exchange agreement previously entered into as of December 28, 2021, between Cellvera f/k/a AiPharma Global
Holdings, LLC (together with other affiliates and subsidiaries) and the Company, and all other related agreements, will be terminated.
The
obligations of the Company to consummate the closing under the Asset Purchase Agreement are subject to the satisfaction or waiver, at
or prior to the closing of certain conditions, including but not limited to, the following:
|
(i) |
Satisfactory completion of due diligence; |
|
(ii) |
Completion by the Company of financing sufficient to consummate the
transactions contemplated by the Asset Purchase Agreement; |
|
(iii) |
Receipt by the Company of all required consents from governmental bodies
for the acquisition, including but not limited to, any consents required to complete the transfer and assignment of Cellvera’s
membership interests in GRA; |
|
(iv) |
Receipt of executed payoff letters reflecting the amount required to
be fully pay all of each of Seller’s and Seller Owner’s debt to be paid at closing; |
|
(v) |
Receipt by the Company of a release from Agility; |
|
(vi) |
Execution of an agreement acceptable to the Company with respect to
the acquisition by the Company of certain intellectual property presently held by a third party; |
|
(vii) |
Execution of an amendment to an asset purchase agreement previously
entered into by Cellvera with a third party that effectively grants the Company the rights to acquire the intellectual property from
the third party under such agreement; |
|
(viii) |
Receipt of a fairness opinion by the Company with respect to the transactions
contemplated by the Asset Purchase Agreement; and |
|
(ix) |
Receipt by the Company from the Seller Owner of written consent, whether
through its official liquidator or the board of directors of Seller Owner, to the sale and purchase of the acquired assets and assumed
liabilities pursuant to the Asset Purchase Agreement. |
There
can be no assurance that the conditions to closing will be satisfied or that the proposed acquisition will be completed as proposed or
at all.
Our
commitment to building our antiviral portfolio is strategic and timely. We believe that there has never has there been a more important
time to address the growing global need to uncover new treatments or commercialize existing ones that treat life-threatening global viral
infections.
Recent
Developments
Amended and Restated Agreement and Plan of Merger
On
July 12, 2024 (the “Execution Date”), the Company entered into an Amended and Restated Agreement and Plan of Merger
(the “Merger Agreement”) with Adifem, Inc. f/k/a Adicure, Inc., a Delaware corporation and wholly owned subsidiary
of the Company (“Merger Sub”) and Evofem Biosciences, Inc., a Delaware corporation (“Evofem”),
pursuant to which, Merger Sub will be merged into and with Evofem (the “Merger”), with Evofem surviving the Merger
as a wholly owned subsidiary of the Company. The Merger Agreement amended and restated that certain Agreement and Plan of Merger dated
as of December 11, 2023, as subsequently amended as described below, by and among the Company, Merger Sub and Evofem (as amended, the
“Original Agreement”).
On
January 8, 2024, the Company, Adicure and Evofem entered into the First Amendment to the Merger Agreement (the “First Amendment
to Merger Agreement”), pursuant to which the parties agreed to extend the date by which the joint proxy statement would be
filed with the SEC until February 14, 2024. On January 30, 2024, the Company, Adicure and Evofem entered into the Second Amendment to
the Merger Agreement (the “Second Amendment to Merger Agreement”) to amend (i) the date of the Parent Loan (as
defined in the Merger Agreement) to Evofem to be February 29, 2024, (ii) to change the date by which Evofem may terminate the Merger
Agreement for failure to receive the Parent Loan to be February 29, 2024, and (iii) to change the filing date for the Joint Proxy Statement
(as defined in the Merger Agreement) to April 1, 2024. On February 29, 2024, the Company, Adicure and Evofem entered into
the Third Amendment to the Merger Agreement (the “Third Amendment to Merger Agreement”) in order to (i) make certain
conforming changes to the Merger Agreement regarding the Notes, (ii) extend the date by which the Company and Evofem will file the joint
proxy statement until April 30, 2024, and (iii) remove the requirement that the Company make the Parent Loan (as defined in the Merger
Agreement) by February 29, 2024 and replace it with the requirement that the Company make an equity investment into Evofem consisting
of (a) a purchase of 2,000 shares of Evofem Series F-1 Preferred Stock for an aggregate purchase price of $2.0 million on or prior to
April 1, 2024, and (b) a purchase of 1,500 shares of Evofem Series F-1 Preferred Stock for an aggregate purchase price of $1.5 million
on or prior to April 30, 2024. On April 26, 2024, the Company received notice from Evofem (the “Termination Notice”)
that Evofem was exercising its right to terminate the Merger Agreement as a result of the Company’s failure to provide the Initial
Parent Equity Investment (as defined in the Merger Agreement, as amended).
On
May 2, 2024, the Company, Adifem, Inc. f/k/a Adicure, Inc. and Evofem entered into the Reinstatement and Fourth Amendment to the Merger
Agreement (the “Fourth Amendment”) in order to waive and amend, among other things, the several provisions listed
below.
Amendments to Article
VI: Covenants and Agreement
Article VI of the Merger
Agreement is amended to:
| ● | reinstate
the Merger Agreement, as amended by the Fourth Amendment, as if never terminated; |
| ● | reflect
the Company’s payment to Evofem, in the amount of $1,000,000 (the “Initial
Payment”), via wire initiated by May 2, 2024; |
| ● | delete
Section 6.3, which effectively eliminates the “no shop” provision, and the several
defined terms used therein; |
| ● | add
a new defined term “Company Change of Recommendation;” and |
| ● | revise
section 6.10 of the Merger Agreement such that, after the Initial Payment, and upon the closing
of each subsequent capital raise by the Company (each a “Parent Subsequent Capital
Raise”), the Company shall purchase that number of shares of Evofem’s Series
F-1 Preferred Stock, par value $0.0001 per share (the “Series F-1 Preferred Stock”),
equal to forty percent (40%) of the gross proceeds of such Parent Subsequent Capital Raise
divided by 1,000, up to a maximum aggregate amount of $2,500,000 or 2,500 shares of Series
F-1 Preferred Stock. A maximum of $1,500,000 shall be raised prior to June 17, 2024 and $1,000,000
prior to July 1, 2024 (the “Parent Capital Raise”). |
Amendments
to Article VIII: Termination
Article
VIII of the Merger Agreement is amended to:
| ● | extend
the date after which either party may terminate from May 8, 2024 to July 15, 2024; |
| ● | revise
Section 8.1(d) in its entirety to allow Company to terminate at any time after there has
been a Company Change of Recommendation, provided that Aditxt must receive ten day written
notice and have the opportunity to negotiate a competing offer in good faith; and |
| | |
| ● | amend
and restate Section 8.1(f) in its entirety, granting the Company the right to terminate the
agreement if (a) the full $1,000,000 Initial Payment required by the Fourth Amendment has
not been paid in full by May 3, 2024 (b) $1,500,000 of the Parent Capital Raise Amount has
not been paid to the Company by June 17, 2024, (c) $1,000,000 of the Parent Capital Raise
Amount has not been paid to the Company by July 1, 2024, or (d) Aditxt does not pay any portion
of the Parent Equity Investment within five calendar days after each closing of a Parent
Subsequent Capital Raise. |
Except
as described below, the terms and conditions of the Merger Agreement are consistent with the terms and provisions of the Original Agreement.
Effect
on Capital Stock
Subject
to the terms and conditions set forth in the Merger Agreement, at the effective time of the Merger (the “Effective Time”),
(i) all issued and outstanding shares of common stock, par value $0.0001 per share of Evofem (“Evofem Common Stock”),
other than any shares of Evofem Common Stock either held by the Company or Merger Sub immediately prior to the Effective Time or which
are Dissenting Shares (as hereinafter defined), will be converted into the right to receive an aggregate of $1,800,000; and (ii) each
issued and outstanding share of Series E-1 Preferred Stock, par value $0.0001 of Evofem (the “Evofem Unconverted Preferred Stock”),
other than any shares of Evofem Unconverted Preferred Stock either held by the Company or Merger Sub immediately prior to the Effective
Time or which are Dissenting Shares, will be converted into the right to receive one (1) share of Series A-2 Preferred Stock, par value
$0.001 of the Company (the “Company Preferred Stock”), having such rights, powers, and preferences set forth in the
form of Certificate of Designation of Series A-2 Preferred Stock, the form of which is attached as Exhibit C to the Merger Agreement.
Any
Evofem capital stock outstanding immediately prior to the Effective Time and held by an Evofem shareholder who has not voted in favor
of or consented to the adoption of the Merger Agreement and who is entitled to demand and has properly demanded appraisal for such Company
Capital Stock in accordance with the Delaware General Corporation Law (“DGCL”), and who, as of the Effective Time,
has not effectively withdrawn or lost such appraisal rights (such Evofem capital Stock, “Dissenting Shares”) shall
not be converted into or be exchangeable for the right to receive a portion of the Merger Consideration and, instead, shall be entitled
to only those rights as set forth in the DGCL. If, after the Effective Time, any such holder fails to perfect or withdraws or loses his,
her or its right to appraisal under the DGCL, with respect to any Dissenting Shares, upon surrender of the certificate(s) representing
such Dissenting Shares, such Dissenting Shares shall thereupon be treated as if they had been converted as of the Effective Time into
the right to receive the portion of the merger consideration, if any, to which such Evofem capital stock is entitled pursuant to the
Merger Agreement, without interest.
As
a closing condition for the Company, there shall be no more than 4,141,434 Dissenting Shares that are Evofem Common Stock or 98 Dissenting
Shares that are Evofem Preferred Stock.
At
the Effective Time, each option outstanding under the Evofem 2014 Equity Incentive Plan, the Evofem 2018 Inducement Equity Incentive
Plan and the Evofem 2019 Employee Stock Purchase Plan (collectively, the “Evofem Option Plans”), whether or not vested,
will be canceled without the right to receive any consideration, and the board of directors of Evofem shall take such action such that
the Evofem Option Plans are cancelled as of the Effective Time.
As
soon as practicable following the Execution Date, Evofem will take all action that may be reasonably necessary to provide that: (i) no
new offering period will commence under the Evofem 2019 Employee Stock Purchase Plan (the “Evofem ESPP”); (ii) participants
in the Evofem ESPP as of the Execution Date shall not be permitted to increase their payroll deductions or make separate non-payroll
contributions to the Evofem ESPP; and (iii) no new participants may commence participation in the Evofem ESPP following the Execution
Date. Prior to the Effective Time, Evofem will take all action that may be reasonably necessary to: (A) cause any offering period or
purchase period that otherwise be in progress at the Effective Time to be the final offering period under the Evofem ESPP and to be terminated
no later than five business days prior to the anticipated closing date (the “Final Exercise Date”); (B) make any pro-rata
adjustments that may be necessary to reflect the shortened offering period or purchase period; (C) cause each participant’s then-outstanding
share purchase right under the Evofem ESPP to be exercised as of the Final Exercise Date; and (D) terminate the Evofem ESPP, as of and
contingent upon, the Effective Time.
Securities Purchase Agreement – Evofem
Series F-1 Convertible Preferred Stock
On
July 12, 2024 (the “Closing Date”), the Company completed the Initial Parent Equity Investment (as defined under the
Merger Agreement) and entered into a Securities Purchase (the “Series F-1 Securities Purchase Agreement”) with Evofem,
pursuant to which the Company purchased 500 shares of Evofem’s Series F-1 Convertible Preferred Stock par value $0.0001 per share
(“Evofem F-1 Preferred Stock”) for an aggregate purchase price of $500,000. In connection with the Series F-1 Securities
Purchase Agreement, the Company and Evofem entered into a Registration Rights Agreement (the “Registration Rights Agreement”),
pursuant to which Evofem agreed to file with the SEC a registration statement covering the resale of the shares of its common stock issuable
upon conversion of the Evofem Series F-1 Preferred Stock within 300 days of the Closing Date and to have such registration statement
declared effective by the SEC the earlier of the (i) 90th calendar day after the Closing Date and (ii) 2nd Business
Day after the date Evofem is notified (orally or in writing, whichever is earlier) by the SEC that such registration statement will not
be reviewed or will not be subject to further review.
Pursuant
to the Merger Agreement, the Company is also obligated to purchase: (i) an additional 500 shares of Evofem Series F-1 Preferred Stock
for an additional aggregate purchase price of $500,000 on or prior to August 9, 2024; (ii) an additional 2,000 shares of Evofem Series
F-1 Preferred Stock for an additional purchase price of $2 million on the earlier of August 30, 2024 or 5 business days of the closing
of a public offering by the Company resulting in aggregate net proceeds to the Company of no less than $20 million; and (iii) an additional
1,000 shares of Evofem Series F-1 Preferred Stock for an additional purchase price of $1 million on or prior to September 30, 2024.
Promissory Note
On
April 10, 2024, Sixth Borough Capital Fund, LP (“Sixth Borough”) loaned the Company $230,000. The loan was evidenced by an
unsecured promissory note (the “Sixth Borough April Note”). Pursuant to the terms of the Sixth Borough April Note, it will
accrue interest at the prime rate of 8.5% per annum and is due on the earlier of April 19, 2024 or an event of default, as defined therein.
On May 9, 2024, at which point the balance of the loan was $35,256, Sixth Borough loaned an additional $20,000 to the Company, bringing
the balance of the loan to $55,256.03. The loan was evidenced by an unsecured promissory note (the “Upsize Note”). Pursuant
to the terms of the Upsize Note, it accrued interest at the 15% per annum and was due on the earlier of June 9, 2024 (the “Maturity
Date”) or an event of default, as defined therein. The Company failed to repay the balance on the Maturity Date, and as such was
in default on the Upsize Note.
On June 20, 2024, at which
point the balance of the Upsize Note was $56,187, Sixth Borough loaned an additional $50,000 to the Company and the Company issued a
new note (the “New Note”) to Sixth Borough in the principal amount of $116,806, which includes an original issue discount
of 10%. The New Note is subordinate and junior, in all respects, to those certain senior notes in the aggregate principal amount of $986,380
due August 22, 2024 issued by the Company on May 22, 2024 (the “May 2024 Senior Notes”). The New Note bears interest at a
rate of 8% per annum and is due on the earlier of (i) November 21, 2024; or (ii) at or before the final closing of the next series of
public or private financings, totaling $750,000 or more in the aggregate by the Company, subject to the prior payment in full of all
amounts then owing on the May 2024 Senior Notes; or (iii) an Event of Default (as defined in the New Note).
Lease Default
The Company is party to a
lease agreement dated as of May 4, 2021 by and between LS Biotech Eight, LLC (the “Landlord”) and the Company (the “Lease”).
On May 10, 2024, the Company received written notice (the “Lease Default Notice”) from the Landlord that the Company was
in violation of its obligation to (i) pay Base Rent (as defined in the Lease) and Additional Rent (as defined in the Lease) in the amount
of $431,182.32 in the aggregate, together with administrative charges and interest, as well as (ii) replenish the Security Deposit (as
defined in the Lease) in the amount of $159,375.00, all as required under the Lease. Pursuant to the Lease Default Notice, the Landlord
has demanded that a payment of $590,557.31 plus administrative charges and interest, which shall accrue at the Default Rate (as defined
in the Lease) be made no later than May 17, 2024. On July 18, 2024 the Company made a payment of $86,279 against the outstanding balance.
The Company and the Landlord are currently in talks to agree upon a payment plan.
The Company is working with
the Landlord to come to an amicable resolution. However, no assurance can be given that the parties will reach an amicable resolution
on a timely basis, on favorable terms, or at all.
Equity Line of Credit
On May 2, 2024, we entered
into a common stock purchase agreement (the “ELOC Purchase Agreement”) with an equity line investor (the “ELOC Investor”),
pursuant to which the ELOC Investor has agreed to purchase from us, at our direction from time to time, in its sole discretion, from
and after the date effective date of the ELOC Registration Statement (as defined below) and until the termination of the ELOC Purchase
Agreement, shares of our common stock having a total maximum aggregate purchase price of $150,000,000 (the “ELOC Purchase Shares”),
upon the terms and subject to the conditions and limitations set forth in the ELOC Purchase Agreement.
In connection with the ELOC
Purchase Agreement, we also entered into a registration rights agreement with the ELOC Investor (the “ELOC Registration Rights
Agreement”), pursuant to which the Company agreed to file a registration statement with the SEC covering the resale of the shares
of common stock issued to the ELOC Investor pursuant to the ELOC Purchase Agreement (the “ELOC Registration Statement”) by
the later of (i) the 30th calendar day following the closing date, and (ii) the second business day following Stockholder
Approval (as defined below).
We may, from time to time
and at our sole discretion, direct the ELOC Investor to purchase shares of our common stock upon the satisfaction of certain
conditions set forth in the ELOC Purchase Agreement at a purchase price per share based on the market price of our common stock at the
time of sale as computed under the ELOC Purchase Agreement. There is no upper limit on the price per share that the ELOC Investor could
be obligated to pay for our common stock under the ELOC Purchase Agreement. We will control the timing and amount of any sales of our
common stock to the ELOC Investor, and the Investor has no right to require us to sell any shares to it under the ELOC
Purchase Agreement. Actual sales of shares of our common stock to the ELOC Investor under the ELOC Purchase Agreement will
depend on a variety of factors to be determined by us from time to time, including (among others) market conditions, the trading price
of our common stock and determinations by us as to available and appropriate sources of funding for the Company and our operations. The
ELOC Investor may not assign or transfer its rights and obligations under the ELOC Purchase Agreement.
Under the applicable Nasdaq
rules, in no event may we issue to the ELOC Investor under the ELOC Purchase Agreement more than 332,876 shares of common stock,
which number of shares is equal to 19.99% of the shares of the common stock outstanding immediately prior to the execution of the ELOC
Purchase Agreement (the “Exchange Cap”), unless (i) we obtain stockholder approval to issue shares of common stock in excess
of the Exchange Cap in accordance with applicable Nasdaq rules (“Stockholder Approval”), or (ii) the average price per share
paid by the ELOC Investor for all of the shares of common stock that we direct the ELOC Investor to purchase from
us pursuant to the ELOC Purchase Agreement, if any, equals or exceeds the official closing sale price on the Nasdaq Capital Market immediately
preceding the delivery of the applicable purchase notice to the Investor and (B) the average of the closing sale prices of our common
stock on the Nasdaq Capital Market for the five business days immediately preceding the delivery of such purchase notice.
In all cases, we may not
issue or sell any shares of our common stock to the ELOC Investor under the ELOC Purchase Agreement which, when aggregated
with all other shares of our common stock then beneficially owned by the ELOC Investor and its affiliates, would result in the
ELOC Investor beneficially owning more than 4.99% of the outstanding shares of the Company’s common stock.
The net proceeds under the
ELOC Purchase Agreement to us will depend on the frequency and prices at which we sell shares of its stock to the ELOC Investor.
The Company expects that any proceeds received by it from such sales to the ELOC Investor will be used for working capital
and general corporate purposes.
May 2024 Private Placement
On
May 2, 2024, we entered into a securities purchase agreement (the “Purchase Agreement”) with certain accredited investors,
pursuant to which we agreed to issue and sell to such investors in a private placement (the “Private Placement”): (i) an
aggregate of 4,186 shares of our Series C-1 Convertible Preferred Stock (the “Series C-1 Preferred Stock”); (ii) an aggregate
of 4,186 shares of our Series D-1 Preferred Stock (the “Series D-1 Preferred Stock”); and (iii) warrants (the “Warrants”)
to purchase up to an aggregate of 1,613,092 shares of our common stock.
The
Warrants are exercisable commencing six months following the initial issuance date at an initial exercise price of $2.47 per share and
expire five years from the date of issuance.
On
May 2, 2024, in connection with the Purchase Agreement, we entered into a registration rights agreement with the investors (the “Registration
Rights Agreement”), pursuant to which we agreed to prepare and file with the SEC a registration statement on Form S-3 (the “Registration
Statement”) covering the resale of the shares of our common stock issuable upon conversion of the Series C-1 Preferred Stock (the
“Conversion Shares”) and upon exercise of the Warrants (the “Warrant Shares”): (i) on the later of (x) the 30th calendar
day after the closing date, or (y) the 2nd business day following the Stockholder Approval Date (as defined in the Purchase
Agreement), with respect to the initial registration statement; and (ii) on the date on which we are required to file any additional
Registration Statement pursuant to the terms of the Registration Rights Agreement with respect to any additional Registration Statements
that may be required to be filed by us (the “Filing Deadline”). Pursuant to the Registration Rights Agreement, we are required
to have the initial Registration Statement declared effective by the SEC on the earlier of: (x) the 60th calendar day
after the Filing Deadline (or the 90th calendar day after the Filing Deadline if subject to a full review by the SEC);
and (y) the 2nd business day after the date the Company is notified by the SEC that such Registration Statement will
not be reviewed. In the event that we fail to file the Registration Statement by the Filing Deadline, have it declared effective by the
Effectiveness Deadline, or the prospectus contained therein is not available for use or the investor is not otherwise able to sell its
Warrant Shares pursuant to Rule 144, we shall be required to pay the investor an amount equal to 2% of such investor’s Purchase
Price (as defined in the Purchase Agreement) on the date of such failure and on every thirty date anniversary until such failure is cured.
May 2024 Senior Note
On
May 20, 2024, we issued and sold a senior note (the “Senior Note”) to an accredited
investor (the “Holder”) in the original principal amount of $93,918.75 for a
purchase price of $75,135.00, reflecting an original issue discount of $18,783.75. Unless earlier redeemed, the Senior Note will mature
on August 18, 2024 (the “Note Maturity Date”), subject to extension at the option
of the Holder in certain circumstances as provided in the Senior Note. The Senior Note bears interest at a rate of 8.5% per annum, which
is compounded each calendar month and is payable in arrears on the Note Maturity Date. The Senior Note contains certain standard events
of default, as defined in the Senior Note (each, an “Event of Default”). Upon
the occurrence of an Event of Default, the interest rate shall be increased to 18% per annum and the Holder may require the Company to
redeem the Senior Note, subject to an additional 5% redemption premium. In addition, if we sell any shares of our common stock pursuant
to any equity line of credit, we are required to redeem in cash a portion of the Senior Note equal to the lesser of: (i) the outstanding
amount of the Senior Note; and (ii) 80% of 30% of such equity line proceeds, at a redemption price calculated based upon $1.20 for each
$1.00 of outstanding amount of the Senior Note. The Senior Note also contains an exchange right, which permits the Holder, in its discretion,
to exchange the Senior Note, in whole or in part, for securities to be sold by us in a subsequent placement, subject to certain exceptions
and an additional 20% premium of the amount of the Senior Note exchanged. The Senior Note is a senior, unsecured obligation of the Company,
ranking senior to all other unsecured indebtedness of the Company.
May
2024 Private Placement
On
May 24, 2024, we entered into a securities purchase agreement (the “Securities Purchase Agreement”) with certain accredited
investors pursuant to which we issued and sold senior notes in the aggregate principal amount of $986,379.68 (the “Notes”)
maturing on August 22, 2024, which included the exchange of the previously issued Senior Note in the principal amount of $93,918.75.
The Company received cash proceeds of $775,000 from the sale of the Notes.
Upon
an Event of Default (as defined in the Notes), the Notes will bear interest at a rate of 14% per annum and the holder shall have the
right to require the Company to redeem the Notes at a redemption premium of 125%. In addition, while the Notes are outstanding, the Company
is required to utilize 100% of the proceeds from any offering of securities to redeem the Notes. Pursuant to the Securities Purchase
Agreement, the Company agreed to use commercially reasonable efforts, including the filing of a registration statement with the SEC for
a public offering, to pursue and consummate a financing transaction within 90 days of the closing date. In connection with the issuance
of the Notes, the Company issued an aggregate of 328,468 shares of its common stock (the “Commitment Shares”) as a commitment
fee to the investors. Pursuant to the Securities Purchase Agreement, the Company also agreed to file a registration statement with the
SEC covering the resale of the Commitment Shares as soon as practicable following notice from an investor, and to cause such registration
statement to become effective within 60 days following the filing thereof.
July 2024 Senior Note
On July 9, 2024, we entered
into a Securities Purchase Agreement (the “July 2024 Securities Purchase Agreement”) with an accredited investor (the “July
2024 Purchaser”) pursuant to which we issued and sold a senior note in the principal amount of $625,000 (the “July 2024 Note”)
maturing on October 7, 2024. We received cash proceeds of $500,000 from the sale of the July 2024 Note.
Upon
an Event of Default (as defined in the July 2024 Note), the July 2024 Note will bear interest
at a rate of 14% per annum and the holder shall have the right to require us to redeem the
July 2024 Note at a redemption premium of 125%. In addition, while the July 2024 Note is
outstanding, we are required to utilize 100% of the proceeds from any offering of securities
to redeem the July 2024 Note. Pursuant to the July 2024 Securities Purchase Agreement, we
agreed to use commercially reasonable efforts, including the filing of a registration statement
with SEC for a public offering, to pursue and consummate a financing transaction within 90
days of the closing date. In connection with the issuance of the July 2024 Note, we issued
the July 2024 Purchaser a warrant (the “July 2024 Note Warrant”) to purchase
up to 1,250,000 shares of our common stock (the “July 2024 Warrant Shares”).
Pursuant to the July 2024 Securities Purchase Agreement, we also agreed to file a registration
statement with the SEC covering the resale of the July 2024 Warrant Shares as soon as practicable
following notice from an investor, and to cause such registration statement to become effective
within 60 days following the filing thereof. The July 2024 Warrant is exercisable following
Stockholder Approval (as defined in the July 2024 Securities Purchase Agreement) at an initial
exercise price of $1.49 for a term of five years.
Warrant Amendment and Exercise
On July 9, 2024, we entered
into an amendment to common stock purchase warrants (the “July 2024 Warrant Amendment”) with the holder (the “Holder”)
of certain of our warrants originally issued in December 2023, April 2023, September 2022, December 2021, August 2021, and September
2020 (collectively, the “Outstanding Warrants”), pursuant to which the Company and the Holder agreed to amend each of the
Outstanding Warrants to lower the exercise price of the Outstanding Warrants to $1.49 per share.
On July 17, 2024 the Holder
exercised 836,570 warrants into 836,570 shares of the Company’s common stock.
Arrangement Agreement with Appili Therapeutics, Inc.
On April 1, 2024, we entered
into an arrangement agreement (the “Arrangement Agreement”) with Adivir, a wholly owned subsidiary of the Company and Appili
Therapetics, Inc. (“Appili”) pursuant to which Adivir will acquire all of the issued
and outstanding Class A common shares of Appili (the “Appili Shares”) on the terms and subject to the conditions set forth
therein. The acquisition of the Appili Shares (the “Arrangement”) will be completed by way of a statutory plan of arrangement
under the Canada Business Corporation Act.
At
the effective time of the Arrangement (the “Arrangement Effective Time”), each Appili Share outstanding immediately prior
to the Arrangement Effective Time (other than Appili Shares held by a registered holder of Appili Shares who has validly exercised such
holder’s dissent rights) will be deemed to be assigned and transferred by the holder thereof to Adivir in exchange for: (i) $0.0467
in cash consideration per share for an aggregate cash payment of $5,668,222 (the “Cash Consideration”); and (ii) 0.002745004
of a share of our common stock or an aggregate of 332,876 shares (the “Consideration Shares” and together with the Cash Consideration,
the “Transaction Consideration”). In connection with the transaction, each outstanding option and warrant of Appili will
be cashed-out based on the implied in-the-money value of the Transaction Consideration, which is expected to result in an additional
aggregate cash payment of approximately $341,000 (based on the number of issued and outstanding options and warrants and exchange rates
as of the date of the Arrangement Agreement).
The respective obligations
of each of the Company, Adivir and Appili to consummate the closing of the Arrangement (the “Closing”) are subject to the
satisfaction or waiver, at or prior to the closing of the following conditions:
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(i) |
the Interim Order (as defined in the Arrangement Agreement) shall have
been granted on terms consistent with the Arrangement Agreement and the Interim Order shall not have been set aside or modified in
a manner unacceptable to either party; |
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(ii) |
the Arrangement Resolution (as defined in the Arrangement Agreement)
shall have been adopted by the Appili shareholders at the Appili shareholders’ meeting in accordance with the Interim Order; |
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(iii) |
the Final Order (as defined in the Arrangement Agreement) shall have
been granted on terms consistent with the Arrangement Agreement and the Final Order shall not have been set aside or modified in
a manner unacceptable to either party; |
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(iv) |
completion of an equity or debt financing by the Company with minimum
gross proceeds of at least $20 million (the “Financing”); |
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(v) |
there shall not be any law or order which prevents, prohibits or makes
the consummation of the Arrangement illegal or otherwise prohibits the consummation of the Arrangement or the other transaction contemplated
by the Arrangement Agreement; |
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(vi) |
the issuance of the Consideration Shares will be exempt from the registration
requirements of: (A) the Securities Act of 1933, as amended (the “Securities Act”) pursuant to Section 3(a)(10) of the
Securities Act; and (B) all applicable U.S. securities laws; |
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(vii) |
the distribution of the Consideration Shares pursuant to the Arrangement
shall be exempt from the prospectus and registration requirements of applicable securities laws ; and |
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(viii) |
the Consideration Shares to be issued pursuant to the Arrangement shall,
subject to customary conditions, have been approved for listing on Nasdaq. |
The Company and Adivir
The obligations of the Company
and Adivir to consummate the Closing are subject to the satisfaction or waiver, at or prior to the Closing of certain conditions, including
but not limited to, the following:
|
(i) |
as qualified in the Arrangement Agreement, the representations and
warranties of Appili are true and correct as of the Arrangement Effective Time as if made as at and as of such time; |
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(ii) |
Appili shall have fulfilled or complied in all material respects with
each of its obligations, covenants and agreements contained in the Arrangement Agreement; |
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(iii) |
dissent rights will not have been exercised with respect to more than
10% of the issued and outstanding Appili Shares; |
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(iv) |
the LZH Consent Agreement (as defined in the Arrangement Agreement)
continues to remain in full force and effect and enforceable against the parties thereto and the parties thereto have performed their
respective obligations thereunder required to be completed on or before the Closing; |
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(v) |
there shall not have been a Material Adverse Effect (as defined in
the Arrangement Agreement) on Appili; and |
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(vi) |
there is no action or proceeding pending or threatened by any governmental
entity that prohibits the Company from acquiring, holding or exercising full rights of ownership of the Appili Shares, prevents or
materially delays the consummation of the Arrangement, or prohibits or restricts in any material respect the ownership or operation
of the business of the Company or Appili. |
Appili
The obligations of Appili
to consummate the Closing are subject to the satisfaction or waiver, at or prior to the Closing of the following conditions:
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(i) |
as qualified in the Arrangement Agreement, the representations and
warranties of the Company and Adivir are true and correct as of the Arrangement Effective Time as if made as at and as of such time;
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(ii) |
the Company and Adivir shall have fulfilled or complied in all material
respects with each of its obligations, covenants and agreements contained in the Arrangement Agreement; |
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(iii) |
there shall not have been a Material Adverse Effect (as defined in
the Arrangement Agreement) on the Company or Adivir; |
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(iv) |
the Third-Party Consents (as defined in the Arrangement Agreement)
shall have been obtained; |
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(v) |
there is no action or proceeding pending or threatened by any governmental
entity that cease trades, enjoins or prohibits the Company’s ability to issue the Consideration Shares, or prevents or material
delays the consummation of the Arrangement; |
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(vi) |
the Company shall have taken steps to reconstitute the board of directors
of Adivir such that it will consist of five directors as of the Effective Date, one of whom will be the Company Nominee (as defined
in the Arrangement Agreement); |
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(vii) |
the Company shall have taken steps to have caused the Appointed Officers
(as defined in the Arrangement Agreement) to be duly appointed officers of Adivir; |
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(viii) |
the Company shall satisfy on the Arrangement Effective Date the payment
in immediately available funds as directed in writing by Appili of not less than 50% of the outstanding accounts payable of Appili,
provided that in the event the Company raises gross proceeds of more than $25 million in the Financing, any amounts raised by the
Company in excess of $25 million shall be first applied by the Company to satisfy any unpaid Closing Company Payables (as defined
in the Arrangement Agreement); and |
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(ix) |
the Company shall have deposited with the Depositary (as defined in
the Arrangement Agreement) the Consideration Shares and the Cash Consideration. |
The Arrangement Agreement
may be terminated at any time prior to the consummation of the Closing by mutual written consent of the Company and Appili.
As further set out in the
Arrangement Agreement, either the Company or Appili may also terminate the Arrangement Agreement prior to the Effective Time if: (i)
the Appili shareholders’ meeting is duly convened and held and the Arrangement Resolution (as defined in the Arrangement Agreement)
is voted on by the Appili shareholders and not approved by the Appili shareholders as required by the Interim Order (as defined in the
Arrangement Agreement); (ii) if any Law (as defined in the Arrangement Agreement) is enacted, made, issued, rendered, enforced or amended
following the date of the Arrangement Agreement that prohibits the Arrangement and such Law has become final and non-appealable;
(iii) the Arrangement Effective Time does not occur on or prior to July 31, 2024 (the “Outside Date”); or (iv) the Financing
is not completed on or before 5:00 p.m. (ET) on June 30, 2024 or such later date as the parties may in writing agree.
The Company may terminate
the Arrangement Agreement if prior to the Effective Time: (i) a breach of any representation or warranty or failure to perform any covenant
or agreement on the part of Appili that would cause any Company or Adivir conditions to closing not to be satisfied; (ii) prior to the
approval of the Arrangement Resolution (as defined in the Arrangement Agreement) by the Appili shareholders the Appili board of directors
makes a Company Change in Recommendation (as defined in the Arrangement Agreement) or enters into a written agreement to effect a Company
Acquisition Proposal (as defined in the Arrangement Agreement); (iii) there has been a Material Adverse Effect (as defined in the Arrangement
Agreement) in respect of Appili which is incapable of being cured on or before the Outside Date; (iv) Appili is in material breach of
any of the non-solicitation or match provisions of the Arrangement Agreement; or (v) any of the conditions to closing for the mutual
benefit of the parties or for the benefit of the Company or Adivir cannot be satisfied prior to the Outside Date and such breach or failure
is incapable of being cured, provided that such breach or failure did not result from any action of the Company or Adivir.
Appili may terminate the
Arrangement Agreement if prior to the Arrangement Effective Time: (i) a breach of any representation or warranty or failure to perform
any covenant or agreement on the part of the Company that would cause any Appili conditions to closing not to be satisfied; (ii) prior
to the approval of the Arrangement Resolution (as defined in the Arrangement Agreement) by the Appili shareholders if the Appili board
of directors makes a Company Change in Recommendation (as defined in the Arrangement Agreement) or enters into a written agreement to
effect a Company Superior Proposal (as defined in the Arrangement Agreement); (iii) the Company does not provide the Depositary (as defined
in the Arrangement Agreement) with sufficient consideration to complete the transactions contemplated by the Arrangement Agreement; (iv)
there has occurred a Material Adverse Effect (as defined in the Arrangement Agreement) in respect of the Company which is incapable of
being cured prior to the Outside Date; (v) any of the conditions to closing for the mutual benefit of the parties or for the benefit
of Appili cannot be satisfied prior to the Outside Date and such breach or failure is incapable of being cured, provided that such breach
or failure did not result from any action of Appili; or (vi) the Company does not take all actions within its control that are necessary
to remedy a default on or prior to 5:00 p.m. (ET) on the day that is 15 business days from the date of the Arrangement Agreement.
Termination
Fee
The Company shall be entitled
to a termination fee of CDN$1,250,000 (the “Termination Fee”) in the event that:
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(i) |
the Arrangement Agreement is terminated by Appili or the Company as
a result of a Company Change in Recommendation / to enter into a Company Superior Proposal (both as defined in the Arrangement Agreement);
or |
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(ii) |
the Arrangement Agreement is terminated by the Company as a result
of breach of: (A) a representation, warranty or covenant by Appili (including Appili’s non-solicitation covenants); (B) failure
of the Appili shareholders to approve the Arrangement Resolution (as defined in the Arrangement Agreement); or (C), the Arrangement
Agreement is terminated by the Company or Appili if the Arrangement Effective Time is not prior to the Outside Date, provided that
prior to the termination of the Arrangement Agreement, a Company Acquisition Proposal (as defined in the Arrangement Agreement) has
been made to Appili or announced and within 12 months following the date of such termination: (1) a Company Acquisition Proposal
(as defined in the Arrangement Agreement) made, publicly announced or otherwise communicated to the Appili board prior to the termination
of the Arrangement Agreement is consummated; or (2) Appili enters into a definitive agreement in respect of a Company Acquisition
Proposal (as defined in the Arrangement Agreement) made, publicly announced or otherwise communicated to the Appili board prior to
the termination of the Arrangement Agreement and at any time thereafter such Company Acquisition Proposal (as defined in the Arrangement
Agreement) is consummated. |
Appili shall be entitled
to the Termination Fee in the event that:
|
(i) |
the Arrangement Agreement is terminated by the Company or Appili as
a result of the failure to complete the Financing on or before June 30, 2024; |
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(ii) |
the Arrangement Agreement is terminated by as a result of the failure
to take all actions within its control that are necessary to remedy a default of the Parent (as defined in the Arrangement Agreement)
on or prior to 5:00 p.m. (ET) on the day that is 15 business days from the date of the Arrangement Agreement; |
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(iii) |
the Arrangement Agreement is terminated by Appili as a result of a
breach of a representation, warranty or covenant by the Company or the Arrangement Agreement is terminated by the Company or Appili
if the Arrangement Effective Time is not prior to the Outside Date, provided that prior to the termination of the Arrangement Agreement,
a Parent Acquisition Proposal (as defined in the Arrangement Agreement) has been made to the Company or announced and within 12 months
following the date of such termination: (1) a Parent Acquisition Proposal (as defined in the Arrangement Agreement) made, publicly
announced or otherwise communicated to the Company board prior to the termination of the Arrangement Agreement is consummated; or
(2) the Company enters into a definitive agreement in respect of a Parent Acquisition Proposal (as defined in the Arrangement Agreement)
made, publicly announced or otherwise communicated to the Company board prior to the termination of the Arrangement Agreement and
at any time thereafter such Parent Acquisition Proposal (as defined in the Arrangement Agreement) is consummated. |
On July 1, 2024, the Company,
Adivir and Appili entered into an Amending Agreement (the “Amending Agreement”), pursuant to which the Parties (as defined
in the Arrangement Agreement) agreed that: (i) the Outside Date (as defined in the Arrangement Agreement) would be changed to August
30, 2024; (ii) Adivir agreed that it would convene the Company Meeting (as defined in the Arrangement Agreement) no later than August
30, 2024, provided that Appili shall be under no obligation to convene the Company Meeting prior to the date that is 50 days following
the date that Aditxt delivers to Appili all complete Additional Financial Disclosure (as defined in the Arrangement Agreement) required
for inclusion in the Company Circular (as defined in the Arrangement Agreement); (iii) Aditxt shall use commercially reasonable efforts
to complete the Financing (as defined in the Arrangement Agreement) no later than August 30, 2024; and (iv) Aditxt or Appili may terminate
the Arrangement Agreement if the Financing is not completed by 5:00 p.m. (ET) on August 30, 2024 or such later date as the Parties may
agree in writing.
On July 18, 2024, the Company,
Adivir and Appili entered into a Second Amending Agreement (the “Second Amending Agreement”), pursuant to which the
Arrangement Agreement was further amended to provide that (i) the Outside Date will be extended to September 30, 2024, (ii) the Appili
Meeting will be conducted no later than September 30, 2024, provided that Appili shall be under no obligation to hold the Appili Meting
prior to the date that is 50 days following the date that the Company delivers all complete Additional Financial Disclosure required
for inclusion in the circular; (iii) the Company shall use commercially reasonable efforts to complete the Financing on or prior to September
15, 2024; and (iv) the Company and Appili may terminate the Arrangement Agreement if the Financing is not completed on or before 5:00
p.m. (ET) on September 15, 2024 or such later date as the Parties may in writing agree.
On
July 17, 2024 certain holders of the Company’s A-1 Preferred Stock converted 67 shares
of A-1 Preferred Stock into 82,736 shares of the Company’s common stock.
On
July 19, 2024 certain holders of the Company’s A-1 Preferred Stock converted 121 shares of A-1 Preferred Stock into 150,036 shares
of the Company’s common stock.
On
July 23, 2024 certain holders of the Company’s A-1 Preferred Stock converted 20 shares of A-1 Preferred Stock into 25,829 shares
of the Company’s common stock.
Corporate Information
We were incorporated as a
Delaware corporation on September 28, 2017. Our principal executive offices are located at 2569 Wyandotte Street, Suite 101, Mountain
View, CA 94043, and our telephone number is (650) 870-1200.
The Securities We May Offer
We may offer shares of our
common stock and preferred stock, various series of debt securities and warrants or rights to purchase any of such securities, either
individually or in units, from time to time under this prospectus, together with any applicable prospectus supplement and related free
writing prospectus, at prices and on terms to be determined by market conditions at the time of offering. If we issue any debt securities
at a discount from their original stated principal amount, then, for purposes of calculating the total dollar amount of all securities
issued under this prospectus, we will treat the initial offering price of the debt securities as the total original principal amount
of the debt securities. Each time we offer securities under this prospectus, we will provide offerees with a prospectus supplement that
will describe the specific amounts, prices and other important terms of the securities being offered, including, to the extent applicable:
| ● | designation
or classification; |
| ● | aggregate
principal amount or aggregate offering price; |
| ● | maturity,
if applicable; |
| ● | original
issue discount, if any; |
| ● | rates
and times of payment of interest or dividends, if any; |
| ● | redemption,
conversion, exchange or sinking fund terms, if any; |
| ● | conversion
or exchange prices or rates, if any, and, if applicable, any provisions for changes to or
adjustments in the conversion or exchange prices or rates and in the securities or other
property receivable upon conversion or exchange; |
| ● | restrictive
covenants, if any; |
| ● | voting
or other rights, if any; and |
| ● | important
United States federal income tax considerations. |
A
prospectus supplement and any related free writing prospectus that we may authorize to be provided to you may also add, update, or change
information contained in this prospectus or in documents we have incorporated by reference. However, no prospectus supplement or free
writing prospectus will offer a security that is not registered and described in this prospectus at the time of the effectiveness of
the registration statement of which this prospectus is a part.
We
may sell the securities to or through underwriters, dealers or agents or directly to purchasers.
We, as well as any agents acting on our behalf, reserve the sole right to accept and to reject
in whole or in part any proposed purchase of securities. Each prospectus supplement will
set forth the names of any underwriters, dealers or agents involved in the sale of securities
described in that prospectus supplement and any applicable fee, commission or discount arrangements
with them, details regarding any over-allotment option granted to them, and net proceeds
to us. The following is a summary of the securities we may offer with this prospectus.
Common Stock
We currently have authorized
100,000,000 shares of common stock, par value $0.001 per share. As of July 30, 2024, there were 3,088,910 shares of common stock issued
and 3,088,861 shares of common stock outstanding. We may offer shares of our common stock either alone or underlying other registered
securities convertible into or exercisable for our common stock. Holders of our common stock are entitled to such dividends as our board
of directors (the “Board of Directors” or “Board”) may declare from time to time out of legally available funds,
subject to the preferential rights of the holders of any shares of our preferred stock that are outstanding or that we may issue in the
future. Currently, we do not pay any dividends on our common stock. Each holder of our common stock is entitled to one vote per share.
In this prospectus, we provide a general description of, among other things, the rights and restrictions that apply to holders of our
common stock.
Preferred Stock
We currently have authorized
3,000,000 shares of preferred stock, par value $0.001 per share. As of July 30, 2024, there were 39,277 shares of preferred stock issued
and outstanding. Any authorized and undesignated shares of preferred stock may be issued from time to time in one or more additional
series pursuant to a resolution or resolutions providing for such issue duly adopted by our Board of Directors (authority to do so being
hereby expressly vested in the Board of Directors). The Board of Directors is further authorized, subject to limitations prescribed by
law, to fix by resolution or resolutions the designations, powers, preferences and rights, and the qualifications, limitations or restrictions
thereof, of any wholly unissued series of preferred stock, including without limitation authority to fix by resolution or resolutions
the dividend rights, dividend rate, conversion rights, voting rights, rights and terms of redemption (including sinking fund provisions),
redemption price or prices, and liquidation preferences of any such series, and the number of shares constituting any such series and
the designation thereof, or any of the foregoing.
The rights, preferences,
privileges, and restrictions granted to or imposed upon any series of preferred stock that we offer and sell under this prospectus and
applicable prospectus supplements will be set forth in a certificate of designation relating to the series. We will incorporate by reference
into the registration statement of which this prospectus is a part the form of any certificate of designation that describes the terms
of the series of preferred stock we are offering before the issuance of shares of that series of preferred stock. You should read any
prospectus supplement and any free writing prospectus that we may authorize to be provided to you related to the series of preferred
stock being offered, as well as the complete certificate of designation that contains the terms of the applicable series of preferred
stock.
Debt Securities
We may offer general debt
obligations, which may be secured or unsecured, senior or subordinated, and convertible into shares of our common stock. In this prospectus,
we refer to the senior debt securities and the subordinated debt securities together as the “debt securities.” We may issue
debt securities under a note purchase agreement or under an indenture to be entered between us and a trustee and forms of the senior
and subordinated indentures are included as an exhibit to the registration statement of which this prospectus is a part. The indentures
do not limit the amount of securities that may be issued under it and provides that debt securities may be issued in one or more series.
The senior debt securities will have the same rank as all of our other indebtedness that is not subordinated. The subordinated debt securities
will be subordinated to our senior debt on terms set forth in the applicable prospectus supplement. In addition, the subordinated debt
securities will be effectively subordinated to creditors and preferred stockholders of our subsidiaries. Our Board of Directors will
determine the terms of each series of debt securities being offered. This prospectus contains only general terms and provisions of the
debt securities. The applicable prospectus supplement will describe the particular terms of the debt securities offered thereby. You
should read any prospectus supplement and any free writing prospectus that we may authorize to be provided to you related to the series
of debt securities being offered, as well as the complete note agreements and/or indentures that contain the terms of the debt securities.
Forms of indentures have been filed as exhibits to the registration statement of which this prospectus is a part, and supplemental indentures
and forms of debt securities containing the terms of debt securities being offered will be incorporated by reference into the registration
statement of which this prospectus is a part from reports we file with the SEC.
Warrants
We may offer warrants for
the purchase of shares of our common stock or preferred stock or of debt securities. We may issue the warrants by themselves or together
with common stock, preferred stock or debt securities, and the warrants may be attached to or separate from any offered securities. Any
warrants issued under this prospectus may be evidenced by warrant certificates. Warrants may be issued under a separate warrant agreement
to be entered into between us and the investors or a warrant agent. Our Board of Directors will determine the terms of the warrants.
This prospectus contains only general terms and provisions of the warrants. The applicable prospectus supplement will describe the particular
terms of the warrants being offered thereby. You should read any prospectus supplement and any free writing prospectus that we may authorize
to be provided to you related to the series of warrants being offered, as well as the complete warrant agreements that contain the terms
of the warrants. Specific warrant agreements will contain additional important terms and provisions and will be incorporated by reference
into the registration statement of which this prospectus is a part from reports we file with the SEC.
Rights
We may issue rights to our
stockholders to purchase shares of our common stock, preferred stock or the other securities described in this prospectus. We may offer
rights separately or together with one or more additional rights, debt securities, preferred stock, common stock or warrants, or any
combination of those securities in the form of units, as described in the applicable prospectus supplement. Each series of rights will
be issued under a separate rights agreement to be entered into between us and a bank or trust company, as rights agent. The rights agent
will act solely as our agent in connection with the certificates relating to the rights of the series of certificates and will not assume
any obligation or relationship of agency or trust for or with any holders of rights certificates or beneficial owners of rights. The
following description sets forth certain general terms and provisions of the rights to which any prospectus supplement may relate. The
particular terms of the rights to which any prospectus supplement may relate and the extent, if any, to which the general provisions
may apply to the rights so offered will be described in the applicable prospectus supplement. To the extent that any particular terms
of the rights, rights agreement or rights certificates described in a prospectus supplement differ from any of the terms described below,
then the terms described below will be deemed to have been superseded by that prospectus supplement. Specific rights agreements will
contain additional important terms and provisions and will be incorporated by reference into the registration statement of which this
prospectus is a part from reports we file with the SEC.
Units
We may offer units consisting
of our common stock or preferred stock, debt securities and/or warrants to purchase any of these securities in one or more series. We
may evidence each series of units by unit certificates that we will issue under a separate agreement. We may enter into unit agreements
with a unit agent. Each unit agent will be a bank or trust company that we select. We will indicate the name and address of the unit
agent in the applicable prospectus supplement relating to a particular series of units. This prospectus contains only a summary of certain
general features of the units. The applicable prospectus supplement will describe the particular features of the units being offered
thereby. You should read any prospectus supplement and any free writing prospectus that we may authorize to be provided to you related
to the series of units being offered, as well as the complete unit agreements that contain the terms of the units. Specific unit agreements
will contain additional important terms and provisions and will be incorporated by reference into the registration statement of which
this prospectus is a part from reports we file with the SEC.
RISK FACTORS
An investment in our securities
involves a high degree of risk. This prospectus contains, and the prospectus supplement applicable to each offering of our securities
will contain, a discussion of the risks applicable to an investment in our securities. Prior to making a decision about investing in
our securities, you should carefully consider the specific factors discussed under the heading “Risk Factors” in this
prospectus and the applicable prospectus supplement, together with all of the other information contained or incorporated by reference
in the prospectus supplement or appearing or incorporated by reference in this prospectus. You should also consider the risks, uncertainties
and assumptions discussed under Item 1A, “Risk Factors,” in our Annual Report on Form 10-K for the fiscal year
ended December 31, 2023, filed with the SEC on April 16, 2024, and any updates described in our Quarterly Reports on Form 10-Q,
all of which are incorporated herein by reference, and may be amended, supplemented or superseded from time to time by other reports
we file with the SEC in the future and any prospectus supplement related to a particular offering. The risks and uncertainties we have
described are not the only ones we face. Additional risks and uncertainties not presently known to us or that we currently deem immaterial
may also affect our operations. The occurrence of any of these known or unknown risks might cause you to lose all or part of your investment
in the offered securities.
FORWARD-LOOKING STATEMENTS
This prospectus, any accompanying
prospectus supplement, any related free writing prospectus and the documents incorporated by reference herein or therein contain, in
addition to historical information, certain forward-looking statements within the meaning of Section 27A of the Securities Act, and Section
21E of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), that include information relating to future
events, future financial performance, strategies, expectations, competitive environment, regulatory environment and availability of resources.
Such forward-looking statements include those that express plans, anticipation, intent, contingency, goals, targets or future development
and/or otherwise are not statements of historical fact. These forward-looking statements are based on our current expectations and projections
about future events and they are subject to risks and uncertainties known and unknown that could cause actual results and developments
to differ materially from those expressed or implied in such statements.
In some cases, you can identify
forward-looking statements by terminology, such as “expects,” “anticipates,” “intends,” “estimates,”
“plans,” “believes,” “seeks,” “may,” “should”, “could” or the
negative of such terms or other similar expressions. Accordingly, these statements involve estimates, assumptions and uncertainties that
could cause actual results to differ materially from those expressed in them. Any forward-looking statements are qualified in their entirety
by reference to the factors discussed throughout this prospectus, any accompanying prospectus supplement or incorporated herein by reference.
Risks, uncertainties and
other factors that may cause our actual results, performance or achievements to be different from those expressed or implied in our written
or oral forward-looking statements may be found in this prospectus and any accompanying prospectus supplement under the heading “Risk
Factors” and in our Annual Report on Form 10-K for the fiscal year ended December 31, 2023, filed with the SEC on April 16,
2024 under the headings “Risk Factors” and “Business,” as may be amended, supplemented or superseded
from time to time by other reports we file with the SEC in the future and any prospectus supplement related to a particular offering.
Forward-looking statements
speak only as of the date they are made. You should not put undue reliance on any forward-looking statements. We assume no obligation
to update forward-looking statements to reflect actual results, changes in assumptions or changes in other factors affecting forward-looking
information, except to the extent required by applicable securities laws. If we do update one or more forward-looking statements, no
inference should be drawn that we will make additional updates with respect to those or other forward-looking statements.
New factors emerge from time
to time, and it is not possible for us to predict which factors will arise. In addition, we cannot assess the impact of each factor on
our business or the extent to which any factor, or combination of factors, may cause actual results to differ materially from those contained
in any forward-looking statements. We qualify all of the information presented in this prospectus, any accompanying prospectus supplement
and incorporated herein by reference, and particularly our forward-looking statements, by these cautionary statements.
USE OF PROCEEDS
Except as described in any
prospectus supplement and any free writing prospectus in connection with a specific offering, we currently intend to use the net proceeds
from the sale of the securities offered under this prospectus for research and development and for other general corporate and working
capital purposes. We may also use the net proceeds to repay any debts and/or invest in or acquire additional businesses, products, or
technologies on an opportunistic basis, although we have no current commitments with respect to any such investments or acquisitions
as of the date of this prospectus, other than our obligations under the Evofem Merger Agreement to (i) pay the holders of Evofem common
stock $1.8 million in exchange for all outstanding shares of Evofem common stock; (ii) purchase an
additional 500 shares of Evofem Series F-1 Preferred Stock for an additional aggregate purchase price of $500,000 on or prior to August
9, 2024; (iii) purchase an additional 2,000 shares of Evofem Series F-1 Preferred Stock for an additional purchase price of $2 million
on the earlier of August 30, 2024 or 5 business days of the closing of a public offering by the Company resulting in aggregate net proceeds
to the Company of no less than $20 million; (iv) purchase an additional 1,000 shares of Evofem Series F-1 Preferred Stock for an additional
purchase price of $1 million on or prior to September 30, 2024; and (v) to pay the Cash Consideration of $5,668,222 under the Appili
Arrangement Agreement. We have not determined the amount of net proceeds to be used specifically for the foregoing purposes. As
a result, our management will have broad discretion in the allocation of the net proceeds and investors will be relying on the judgment
of our management regarding the application of the proceeds of any sale of the securities. Pending use of the net proceeds, we intend
to invest the proceeds in short-term, investment-grade, interest-bearing instruments.
Each time we offer securities
under this prospectus, we will describe the intended use of the net proceeds from that offering in the applicable prospectus supplement.
The actual amount of net proceeds we spend on a particular use will depend on many factors, including, our future capital expenditures,
the amount of cash required by our operations, and our future revenue growth, if any. Therefore, we will retain broad discretion in the
use of the net proceeds.
DESCRIPTION OF CAPITAL
STOCK
General
The following description
of our capital stock, together with any additional information we include in any applicable prospectus supplement or any related free
writing prospectus, summarizes the material terms and provisions of our common stock and the preferred stock that we may offer under
this prospectus. While the terms we have summarized below will apply generally to any future common stock or preferred stock that we
may offer, we will describe the particular terms of any class or series of these securities in more detail in the applicable prospectus
supplement. For the complete terms of our common stock and preferred stock, please refer to our Amended and Restated Certificate of Incorporation,
as amended and restated (the “Certificate of Incorporation”) and our bylaws, as amended and restated (the “Bylaws”)
that are incorporated by reference into the registration statement of which this prospectus is a part or may be incorporated by reference
in this prospectus or any applicable prospectus supplement. The terms of these securities may also be affected by Delaware General Corporation
Law (the “DGCL”). The summary below and that contained in any applicable prospectus supplement or any related free writing
prospectus are qualified in their entirety by reference to our Certificate of Incorporation and our Bylaws.
The Company is authorized
to issue 103,000,000 shares of capital stock, par value $0.001 per share, of which 100,000,000 are shares of common stock and 3,000,000
are shares of “blank check” preferred stock.
As of the date of this prospectus,
there were 3,088,910 shares of common stock issued and 3,088,861 shares of common stock outstanding.
Common Stock
Voting
The holders of our common
stock are entitled to one vote for each share held on all matters to be voted on by the Company’s stockholders. There shall be
no cumulative voting.
Dividends
The holders of shares of
our common stock are entitled to dividends when and as declared by the Board of Directors from funds legally available therefor if, as
and when determined by the Board of Directors of the Company in their sole discretion, subject to provisions of law, and any provision
of the Company’s Certificate of Incorporation, as amended from time to time. There are no preemptive, conversion or redemption
privileges, nor sinking fund provisions with respect to the common stock.
Liquidation
In the event of any voluntary
or involuntary liquidation, dissolution or winding up of our affairs, the holders of our common stock will be entitled to share ratably
in the net assets legally available for distribution to stockholders after the payment of or provision for all of our debts and other
liabilities.
Fully Paid and Non-assessable
All outstanding shares of
common stock are duly authorized, validly issued, fully paid and non-assessable.
Preferred Stock
We
are authorized to issue up to 3,000,000 shares of preferred stock, par value $0.001. This preferred stock may be issued in one or more
series, the terms of which may be determined at the time of issuance by our board of directors without further action by stockholders.
The terms of any series of preferred stock may include voting rights (including the right to vote as a series on particular matters),
preferences as to dividend, liquidation, conversion and redemption rights and sinking fund provisions. No preferred stock is currently
outstanding. The issuance of any preferred stock could materially adversely affect the rights of the holders of our common stock, and
therefore, reduce the value of our common stock and the Notes. In particular, specific rights granted to future holders of preferred
stock could be used to restrict our ability to merge with, or sell our assets to, a third party and thereby preserve control by the present
management.
Exclusive Forum
Our
Amended and Restated Certificate of Incorporation provides that unless the Company consents in writing to the selection of an alternative
forum, the State of Delaware is the sole and exclusive forum for: (i) any derivative action or proceeding brought on behalf of the
Company; (ii) any action asserting a claim of breach of a fiduciary duty owed by any director, officer or other employee of the Company
to the Company or the Company’s stockholders; (iii) any action asserting a claim against the Company, its directors, officers or
employees arising pursuant to any provision of the DGCL or our Certificate of Incorporation or the ; Bylaws; or (iv) any action asserting
a claim against the Company, its directors, officers, employees or agents governed by the internal affairs doctrine, except for, as to
each of (i) through (iv) above, any claim as to which the Court of Chancery determines that there is an indispensable party not subject
to the jurisdiction of the Court of Chancery (and the indispensable party does not consent to the personal jurisdiction of the Court
of Chancery within ten days following such determination), which is vested in the exclusive jurisdiction of a court or forum other than
the Court of Chancery, or for which the Court of Chancery does not have subject matter jurisdiction.
Additionally,
our Bylaws provide that unless the Company consents in writing to the selection of an alternative forum, the federal district courts
of the United States of America will be the exclusive forum for the resolution of any complaint asserting a cause of action arising under
the Securities Act. Any person or entity purchasing or otherwise acquiring any interest in shares of capital stock of the Company are
deemed to have notice of and consented to this provision. The Supreme Court of Delaware has held that this type of exclusive federal
forum provision is enforceable. There may be uncertainty, however, as to whether courts of other jurisdictions would enforce such a provision,
if applicable.
Transfer Agent
The transfer agent and registrar
for our common stock is VStock Transfer, LLC.
Changes in Authorized Number
The number of authorized
shares of common stock may be increased or decreased subject to the Company’s legal commitments at any time and from time to time
to issue them, by the affirmative vote of the holders of a majority of the stock of the Company entitled to vote.
Delaware Anti-Takeover Statute
We may become subject to
Section 203 of the DGCL, which prohibits persons deemed to be “interested stockholders” from engaging in a “business
combination” with a publicly held Delaware corporation for three years following the date these persons become interested stockholders
unless the business combination is, or the transaction in which the person became an interested stockholder was, approved in a prescribed
manner or another prescribed exception applies. Generally, an “interested stockholder” is a person who, together with affiliates
and associates, owns, or within three years prior to the determination of interested stockholder status did own, 15% or more of a corporation’s
voting stock. Generally, a “business combination” includes a merger, asset or stock sale, or other transaction resulting
in a financial benefit to the interested stockholder. The existence of this provision may have an anti-takeover effect with respect to
transactions not approved in advance by the Board of Directors. A Delaware corporation may “opt out” of these provisions
with an express provision in its original certificate of incorporation or an express provision in its certificate of incorporation or
bylaws resulting from a stockholders’ amendment approved by at least a majority of the outstanding voting shares. We have not opted
out of these provisions. As a result, mergers or other takeover or change in control attempts of us may be discouraged or prevented.
Our Bylaws establish an advance
notice procedure for stockholder proposals to be brought before an annual meeting of our stockholders, including proposed nominations
of persons for election to our board of directors. At an annual meeting, stockholders may only consider proposals or nominations specified
in the notice of meeting or brought before the meeting by or at the direction of our board of directors. Stockholders may also consider
a proposal or nomination by a person who was a stockholder at the time of giving notice and at the time of the meeting, who is entitled
to vote at the meeting and who has complied with the notice requirements of the Bylaws in all respects. The Bylaws do not give our board
of directors the power to approve or disapprove stockholder nominations of candidates or proposals regarding other business to be conducted
at a special or annual meeting of our stockholders. However, the Bylaws may have the effect of precluding the conduct of certain business
at a meeting if the proper procedures are not followed. These provisions may also discourage or deter a potential acquirer from conducting
a solicitation of proxies to elect the acquirer’s own slate of directors or otherwise attempting to obtain control of our company.
Our Bylaws provide that a
special meeting of our stockholders may be called only by our Chairman or by resolution adopted by a majority of our board of directors.
Because our stockholders do not have the right to call a special meeting, a stockholder could not force stockholder consideration of
a proposal over the opposition of our board of directors by calling a special meeting of stockholders prior to such time as a majority
of our board of directors, the chairperson of our board of directors, the president or the chief executive officer believed the matter
should be considered or until the next annual meeting provided that the requestor met the notice requirements. The restriction
on the ability of stockholders to call a special meeting means that a proposal to replace our board of directors also could be delayed
until the next annual meeting.
DESCRIPTION OF DEBT SECURITIES
The following description,
together with the additional information we include in any applicable prospectus supplements or free writing prospectuses, summarizes
the material terms and provisions of the debt securities that we may offer under this prospectus. We may issue debt securities, in one
or more series, as either senior or subordinated debt or as senior or subordinated convertible debt. While the terms we have summarized
below will apply generally to any future debt securities we may offer under this prospectus, we will describe the particular terms of
any debt securities that we may offer in more detail in the applicable prospectus supplement or free writing prospectus. The terms of
any debt securities we offer under a prospectus supplement may differ from the terms we describe below. However, no prospectus supplement
shall fundamentally change the terms that are set forth in this prospectus or offer a security that is not registered and described in
this prospectus at the time of its effectiveness. As of the date of this prospectus, we have no outstanding registered debt securities.
Unless the context requires otherwise, whenever we refer to the “indentures,” we also are referring to any supplemental indentures
that specify the terms of a particular series of debt securities.
We will issue any senior
debt securities under the senior indenture that we will enter into with the trustee named in the senior indenture. We will issue any
subordinated debt securities under the subordinated indenture and any supplemental indentures that we will enter into with the trustee
named in the subordinated indenture. We have filed forms of these documents as exhibits to the registration statement, of which this
prospectus is a part, and supplemental indentures and forms of debt securities containing the terms of the debt securities being offered
will be filed as exhibits to the registration statement of which this prospectus is a part or will be incorporated by reference from
reports that we file with the SEC.
The indentures will be qualified
under the Trust Indenture Act of 1939, as amended (the “Trust Indenture Act”). We use the term “trustee” to refer
to either the trustee under the senior indenture or the trustee under the subordinated indenture, as applicable.
The following summaries of
material provisions of the senior debt securities, the subordinated debt securities and the indentures are subject to, and qualified
in their entirety by reference to, all of the provisions of the indenture and any supplemental indentures applicable to a particular
series of debt securities. We urge you to read the applicable prospectus supplements and any related free writing prospectuses related
to the debt securities that we may offer under this prospectus, as well as the complete indentures that contains the terms of the debt
securities. Except as we may otherwise indicate, the terms of the senior indenture and the subordinated indenture are identical.
General
The terms of each series
of debt securities will be established by or pursuant to a resolution of our Board of Directors and set forth or determined in the manner
provided in an officers’ certificate or by a supplemental indenture. Debt securities may be issued in separate series without limitation
as to aggregate principal amount. We may specify a maximum aggregate principal amount for the debt securities of any series. We will
describe in the applicable prospectus supplement the terms of the series of debt securities being offered, including:
| ● | the
principal amount being offered, and if a series, the total amount authorized and the total
amount outstanding; |
| ● | any
limit on the amount that may be issued; |
| ● | whether
or not we will issue the series of debt securities in global form, and, if so, the terms
and who the depositary will be; |
| ● | whether
and under what circumstances, if any, we will pay additional amounts on any debt securities
held by a person who is not a United States person for tax purposes, and whether we can redeem
the debt securities if we have to pay such additional amounts; |
| ● | the
annual interest rate, which may be fixed or variable, or the method for determining the rate
and the date interest will begin to accrue, the dates interest will be payable and the regular
record dates for interest payment dates or the method for determining such dates; |
| ● | whether
or not the debt securities will be secured or unsecured, and the terms of any secured debt; |
| ● | the
terms of the subordination of any series of subordinated debt; |
| ● | the
place where payments will be made; |
| ● | restrictions
on transfer, sale or other assignment, if any; |
| ● | our
right, if any, to defer payment of interest and the maximum length of any such deferral period; |
| ● | the
date, if any, after which, and the price at which, we may, at our option, redeem the series
of debt securities pursuant to any optional or provisional redemption provisions and the
terms of those redemption provisions; |
| ● | provisions
for a sinking fund purchase or other analogous fund, if any, including the date, if any,
on which, and the price at which we are obligated, pursuant thereto or otherwise, to redeem,
or at the holder’s option, to purchase, the series of debt securities and the currency
or currency unit in which the debt securities are payable; |
| ● | whether
the indenture will restrict our ability or the ability of our subsidiaries, if any, to: |
| o | incur
additional indebtedness; |
| o | issue
additional securities; |
| o | pay
dividends or make distributions in respect of our capital stock or the capital stock of our
subsidiaries; |
| o | place
restrictions on our subsidiaries’ ability to pay dividends, make distributions or transfer
assets; |
| o | make
investments or other restricted payments; |
| o | sell
or otherwise dispose of assets; |
| o | enter
into sale-leaseback transactions; |
| o | engage
in transactions with stockholders or affiliates; |
| o | issue
or sell stock of our subsidiaries; or |
| o | effect
a consolidation or merger; |
| ● | whether
the indenture will require us to maintain any interest coverage, fixed charge, cash flow-based,
asset-based or other financial ratios; |
| ● | a
discussion of certain material or special United States federal income tax considerations
applicable to the debt securities; |
| ● | information
describing any book-entry features; |
| ● | the
applicability of the provisions in the indenture on discharge; |
| ● | whether
the debt securities are to be offered at a price such that they will be deemed to be offered
at an “original issue discount” as defined in paragraph (a) of Section 1273
of the Internal Revenue Code of 1986, as amended; |
| ● | the
denominations in which we will issue the series of debt securities, if other than denominations
of $1,000 and any integral multiple thereof; |
| ● | the
currency of payment of debt securities if other than U.S. dollars and the manner of determining
the equivalent amount in U.S. dollars; and |
| ● | any
other specific terms, preferences, rights or limitations of, or restrictions on, the debt
securities, including any additional events of default or covenants provided with respect
to the debt securities, and any terms that may be required by us or advisable under applicable
laws or regulations. |
Conversion or Exchange Rights
We will set forth in the
applicable prospectus supplement the terms under which a series of debt securities may be convertible into or exchangeable for our common
stock, our preferred stock or other securities (including securities of a third party). We will include provisions as to whether conversion
or exchange is mandatory, at the option of the holder or at our option. We may include provisions pursuant to which the number of shares
of our common stock, our preferred stock or other securities (including securities of a third party) that the holders of the series of
debt securities receive would be subject to adjustment.
Consolidation, Merger or Sale
Unless we provide otherwise
in the prospectus supplement applicable to a particular series of debt securities, the indentures will not contain any covenant that
restricts our ability to merge or consolidate, or sell, convey, transfer or otherwise dispose of all or substantially all of our assets.
However, any successor to or acquirer of such assets must assume all of our obligations under the indentures or the debt securities,
as appropriate. If the debt securities are convertible into or exchangeable for our other securities or securities of other entities,
the person with whom we consolidate or merge or to whom we sell all of our property must make provisions for the conversion of the
debt securities into securities that the holders of the debt securities would have received if they had converted the debt securities
before the consolidation, merger or sale.
Events of Default under the Indenture
Unless we provide otherwise
in the prospectus supplement applicable to a particular series of debt securities, the following are events of default under the indentures
with respect to any series of debt securities that we may issue:
| ● | if
we fail to pay interest when due and payable and our failure continues for 90 days and the
time for payment has not been extended; |
| ● | if
we fail to pay the principal, premium or sinking fund payment, if any, when due and payable
at maturity, upon redemption or repurchase or otherwise, and the time for payment has not
been extended; |
| ● | if
we fail to observe or perform any other covenant contained in the debt securities or the
indentures, other than a covenant specifically relating to another series of debt securities,
and our failure continues for 90 days after we receive notice from the trustee or we and
the trustee receive notice from the holders of at least 25% in aggregate principal amount
of the outstanding debt securities of the applicable series; and |
| ● | if
specified events of bankruptcy, insolvency or reorganization occur. |
We will describe in each
applicable prospectus supplement any additional events of default relating to the relevant series of debt securities.
If an event of default with
respect to debt securities of any series occurs and is continuing, other than an event of default specified in the last bullet point
above, the trustee or the holders of at least 25% in aggregate principal amount of the outstanding debt securities of that series, by
notice to us in writing, and to the trustee if notice is given by such holders, may declare the unpaid principal, premium, if any, and
accrued interest, if any, due and payable immediately. If an event of default arises due to the occurrence of certain specified bankruptcy,
insolvency or reorganization events, the unpaid principal, premium, if any, and accrued interest, if any, of each issue of debt securities
then outstanding shall be due and payable without any notice or other action on the part of the trustee or any holder.
The holders of a majority
in principal amount of the outstanding debt securities of an affected series may waive any default or event of default with respect to
the series and its consequences, except defaults or events of default regarding payment of principal, premium, if any, or interest, unless
we have cured the default or event of default in accordance with the indenture. Any waiver shall cure the default or event of default.
Subject to the terms of the
indentures, if an event of default under an indenture shall occur and be continuing, the trustee will be under no obligation to exercise
any of its rights or powers under such indenture at the request or direction of any of the holders of the applicable series of debt securities,
unless such holders have offered the trustee reasonable indemnity or security satisfactory to it against any loss, liability or expense.
The holders of a majority in principal amount of the outstanding debt securities of any series will have the right to direct the time,
method and place of conducting any proceeding for any remedy available to the trustee, or exercising any trust or power conferred on
the trustee, with respect to the debt securities of that series, provided that:
| ● | the
direction so given by the holder is not in conflict with any law or the applicable indenture;
and |
| ● | subject
to its duties under the Trust Indenture Act, the trustee need not take any action that might
involve it in personal liability or might be unduly prejudicial to the holders not involved
in the proceeding. |
The indentures will provide
that if an event of default has occurred and is continuing, the trustee will be required in the exercise of its powers to use the degree
of care that a prudent person would use in the conduct of its own affairs. The trustee, however, may refuse to follow any direction that
conflicts with law or the indenture, or that the trustee determines is unduly prejudicial to the rights of any other holder of the relevant
series of debt securities, or that would involve the trustee in personal liability. Prior to taking any action under the indentures,
the trustee will be entitled to indemnification against all costs, expenses and liabilities that would be incurred by taking or not taking
such action.
A holder of the debt securities
of any series will have the right to institute a proceeding under the indentures or to appoint a receiver or trustee, or to seek other
remedies only if:
| ● | the
holder has given written notice to the trustee of a continuing event of default with respect
to that series; |
| ● | the
holders of at least 25% in aggregate principal amount of the outstanding debt securities
of that series have made a written request and such holders have offered reasonable indemnity
to the trustee or security satisfactory to it against any loss, liability or expense or to
be incurred in compliance with instituting the proceeding as trustee; and |
| ● | the
trustee does not institute the proceeding, and does not receive from the holders of a majority
in aggregate principal amount of the outstanding debt securities of that series other conflicting
directions within 90 days after the notice, request and offer. |
These limitations do not
apply to a suit instituted by a holder of debt securities if we default in the payment of the principal, premium, if any, or interest
on, the debt securities, or other defaults that may be specified in the applicable prospectus supplement.
We will periodically file
statements with the trustee regarding our compliance with specified covenants in the indentures.
The indentures will provide
that if a default occurs and is continuing and is actually known to a responsible officer of the trustee, the trustee must mail to each
holder notice of the default within the earlier of 90 days after it occurs and 30 days after it is known by a responsible officer of
the trustee or written notice of it is received by the trustee, unless such default has been cured or waived. Except in the case of a
default in the payment of principal or premium of, or interest on, any debt security or certain other defaults specified in an indenture,
the trustee shall be protected in withholding such notice if and so long as the Board of Directors, the executive committee or a trust
committee of directors, or responsible officers of the trustee, in good faith determine that withholding notice is in the best interests
of holders of the relevant series of debt securities.
Modification of Indenture; Waiver
Subject to the terms of the
indenture for any series of debt securities that we may issue, we and the trustee may change an indenture without the consent of any
holders with respect to the following specific matters:
| ● | to
fix any ambiguity, defect or inconsistency in the indenture; |
| ● | to
comply with the provisions described above under “Description of Debt Securities
— Consolidation, Merger or Sale;” |
| ● | to
comply with any requirements of the SEC in connection with the qualification of any indenture
under the Trust Indenture Act; |
| ● | to
add to, delete from or revise the conditions, limitations and restrictions on the authorized
amount, terms or purposes of issue, authentication and delivery of debt securities, as set
forth in the indenture; |
| ● | to
provide for the issuance of, and establish the form and terms and conditions of, the debt
securities of any series as provided under “Description of Debt Securities —
General,” to establish the form of any certifications required to be furnished
pursuant to the terms of the indenture or any series of debt securities, or to add to the
rights of the holders of any series of debt securities; |
| ● | to
evidence and provide for the acceptance of appointment hereunder by a successor trustee; |
| ● | to
provide for uncertificated debt securities and to make all appropriate changes for such purpose; |
| ● | to
add such new covenants, restrictions, conditions or provisions for the benefit of the holders,
to make the occurrence, or the occurrence and the continuance, of a default in any such additional
covenants, restrictions, conditions or provisions an event of default or to surrender any
right or power conferred to us in the indenture; or |
| ● | to
change anything that does not adversely affect the interests of any holder of debt securities
of any series in any material respect. |
In addition, under the indentures,
the rights of holders of a series of debt securities may be changed by us and the trustee with the written consent of the holders of
at least a majority in aggregate principal amount of the outstanding debt securities of each series that is affected. However, subject
to the terms of the indenture for any series of debt securities that we may issue or otherwise provided in the prospectus supplement
applicable to a particular series of debt securities, we and the trustee may only make the following changes with the consent of each
holder of any outstanding debt securities affected:
| ● | extending
the stated maturity of the series of debt securities; |
| ● | reducing
the principal amount, reducing the rate of or extending the time of payment of interest,
or reducing any premium payable upon the redemption or repurchase of any debt securities;
or |
| ● | reducing
the percentage of debt securities, the holders of which are required to consent to any amendment,
supplement, modification or waiver. |
Discharge
Each indenture provides that,
subject to the terms of the indenture and any limitation otherwise provided in the prospectus supplement applicable to a particular series
of debt securities, we may elect to be discharged from our obligations with respect to one or more series of debt securities, except
for specified obligations, including obligations to:
| ● | register
the transfer or exchange of debt securities of the series; |
| ● | replace
stolen, lost or mutilated debt securities of the series; |
| ● | maintain
paying agencies; |
| ● | hold
monies for payment in trust; |
| ● | recover
excess money held by the trustee; |
| ● | compensate
and indemnify the trustee; and |
| ● | appoint
any successor trustee. |
In order to exercise our
rights to be discharged, we will deposit with the trustee money or government obligations sufficient to pay all the principal of, and
any premium and interest on, the debt securities of the series on the dates payments are due.
Form, Exchange and Transfer
We will issue the debt securities
of each series only in fully registered form without coupons and, unless we otherwise specify in the applicable prospectus supplement,
in denominations of $1,000 and any integral multiple thereof. The indentures will provide that we may issue debt securities of a series
in temporary or permanent global form and as book-entry securities that will be deposited with, or on behalf of, The Depository Trust
Company or another depositary named by us and identified in a prospectus supplement with respect to that series. See “Legal
Ownership of Securities” below for a further description of the terms relating to any book-entry securities.
At the option of the holder,
subject to the terms of the indentures and the limitations applicable to global securities described in the applicable prospectus supplement,
the holder of the debt securities of any series can exchange the debt securities for other debt securities of the same series, in any
authorized denomination and of like tenor and aggregate principal amount.
Subject to the terms of the
indentures and the limitations applicable to global securities set forth in the applicable prospectus supplement, holders of the debt
securities may present the debt securities for exchange or for registration of transfer, duly endorsed or with the form of transfer endorsed
thereon duly executed if so required by us or the security registrar, at the office of the security registrar or at the office of any
transfer agent designated by us for this purpose. Unless otherwise provided in the debt securities that the holder presents for transfer
or exchange, we will make no service charge for any registration of transfer or exchange, but we may require payment of any taxes or
other governmental charges.
We will name in the applicable
prospectus supplement the security registrar, and any transfer agent in addition to the security registrar, that we initially designate
for any debt securities. We may at any time designate additional transfer agents or rescind the designation of any transfer agent or
approve a change in the office through which any transfer agent acts, except that we will be required to maintain a transfer agent in
each place of payment for the debt securities of each series.
If we elect to redeem the
debt securities of any series, we will not be required to:
| ● | issue,
register the transfer of, or exchange any debt securities of that series during a period
beginning at the opening of business 15 days before the day of mailing of a notice of redemption
of any debt securities that may be selected for redemption and ending at the close of business
on the day of the mailing; or |
| ● | register
the transfer of or exchange any debt securities so selected for redemption, in whole or in
part, except the unredeemed portion of any debt securities we are redeeming in part. |
Information Concerning the Trustee
The trustee, other than during
the occurrence and continuance of an event of default under an indenture, undertakes to perform only those duties as are specifically
set forth in the applicable indenture and is under no obligation to exercise any of the powers given it by the indentures at the request
of any holder of debt securities unless it is offered reasonable security and indemnity against the costs, expenses and liabilities that
it might incur. However, upon an event of default under an indenture, the trustee must use the same degree of care as a prudent person
would exercise or use in the conduct of his or her own affairs.
Payment and Paying Agents
Unless we otherwise indicate
in the applicable prospectus supplement, we will make payment of the interest on any debt securities on any interest payment date to
the person in whose name the debt securities, or one or more predecessor securities, are registered at the close of business on the regular
record date for the interest payment.
We will pay principal of
and any premium and interest on the debt securities of a particular series at the office of the paying agents designated by us, except
that unless we otherwise indicate in the applicable prospectus supplement, we will make interest payments by check that we will mail
to the holder or by wire transfer to certain holders. Unless we otherwise indicate in the applicable prospectus supplement, we will designate
the corporate trust office of the trustee as our sole paying agent for payments with respect to debt securities of each series. We will
name in the applicable prospectus supplement any other paying agents that we initially designate for the debt securities of a particular
series. We will maintain a paying agent in each place of payment for the debt securities of a particular series.
All money we pay to a paying
agent or the trustee for the payment of the principal of or any premium or interest on any debt securities that remains unclaimed at
the end of two years after such principal, premium or interest has become due and payable will be repaid to us, and the holder of the
debt security thereafter may look only to us for payment thereof.
Governing Law
The indentures and the debt
securities will be governed by and construed in accordance with the laws of the State of New York, except to the extent that the Trust
Indenture Act is applicable.
Ranking Debt Securities
The subordinated debt securities
will be unsecured and will be subordinate and junior in priority of payment to certain other indebtedness to the extent described in
a prospectus supplement. The subordinated indenture does not limit the amount of subordinated debt securities that we may issue. It also
does not limit us from issuing any other secured or unsecured debt.
The senior debt securities
will be unsecured and will rank equally in right of payment to all our other senior unsecured debt. The senior indenture does not limit
the amount of senior debt securities that we may issue. It also does not limit us from issuing any other secured or unsecured debt.
DESCRIPTION OF WARRANTS
The following description,
together with the additional information we may include in any applicable prospectus supplements and free writing prospectuses, summarizes
the material terms and provisions of the warrants that we may offer under this prospectus, which may consist of warrants to purchase
common stock, preferred stock or debt securities and may be issued in one or more series. Warrants may be offered independently or together
with common stock, preferred stock or debt securities offered by any prospectus supplement, and may be attached to or separate from those
securities. While the terms we have summarized below will apply generally to any warrants that we may offer under this prospectus, we
will describe the particular terms of any series of warrants that we may offer in more detail in the applicable prospectus supplement
and any applicable free writing prospectus. The terms of any warrants offered under a prospectus supplement may differ from the terms
described below. However, no prospectus supplement will fundamentally change the terms that are set forth in this prospectus or offer
a security that is not registered and described in this prospectus at the time of its effectiveness.
We may issue the warrants
under a warrant agreement that we will enter into with a warrant agent to be selected by us. If selected, the warrant agent will act
solely as an agent of ours in connection with the warrants and will not act as an agent for the holders or beneficial owners of the warrants.
If applicable, we will file as exhibits to the registration statement of which this prospectus is a part, or will incorporate by reference
from a Current Report on Form 8-K that we file with the SEC, the form of warrant agreement, including a form of warrant certificate,
that describes the terms of the particular series of warrants we are offering before the issuance of the related series of warrants.
The following summaries of material provisions of the warrants and the warrant agreements are subject to, and qualified in their entirety
by reference to, all the provisions of the warrant agreement and warrant certificate applicable to a particular series of warrants. We
urge you to read the applicable prospectus supplement and any applicable free writing prospectus related to the particular series of
warrants that we sell under this prospectus, as well as the complete warrant agreements and warrant certificates that contain the terms
of the warrants.
General
We will describe in the applicable
prospectus supplement the terms relating to a series of warrants, including:
| ● | the
offering price and aggregate number of warrants offered; |
| ● | the
currency for which the warrants may be purchased; |
| ● | if
applicable, the designation and terms of the securities with which the warrants are issued
and the number of warrants issued with each such security or each principal amount of such
security; |
| ● | if
applicable, the date on and after which the warrants and the related securities will be separately
transferable; |
| ● | in
the case of warrants to purchase debt securities, the principal amount of debt securities
purchasable upon exercise of one warrant and the price at, and currency in which, this principal
amount of debt securities may be purchased upon such exercise; |
| ● | in
the case of warrants to purchase common stock or preferred stock, the number of shares of
common stock or preferred stock, as the case may be, purchasable upon the exercise of one
warrant and the price at which these shares may be purchased upon such exercise; |
| ● | the
effect of any merger, consolidation, sale or other disposition of our business on the warrant
agreements and the warrants; |
| ● | the
terms of any rights to redeem or call the warrants; |
| ● | any
provisions for changes to or adjustments in the exercise price or number of securities issuable
upon exercise of the warrants; |
| ● | the
dates on which the right to exercise the warrants will commence and expire; |
| ● | the
manner in which the warrant agreements and warrants may be modified; |
| ● | United
States federal income tax consequences of holding or exercising the warrants; |
| ● | the
terms of the securities issuable upon exercise of the warrants; and |
| ● | any
other specific terms, preferences, rights or limitations of or restrictions on the warrants. |
|
|
Before exercising their warrants,
holders of warrants will not have any of the rights of holders of the securities purchasable upon such exercise, including: |
| ● | in
the case of warrants to purchase debt securities, the right to receive payments of principal
of, or premium, if any, or interest on, the debt securities purchasable upon exercise or
to enforce covenants in the applicable indenture; or |
| ● | in
the case of warrants to purchase common stock or preferred stock, the right to receive dividends,
if any, or, payments upon our liquidation, dissolution or winding up or to exercise voting
rights, if any. |
Exercise of Warrants
Each warrant will entitle
the holder to purchase the securities that we specify in the applicable prospectus supplement at the exercise price that we describe
in the applicable prospectus supplement. Unless we otherwise specify in the applicable prospectus supplement, holders of the warrants
may exercise the warrants at any time up to the specified time on the expiration date that we set forth in the applicable prospectus
supplement. After the close of business on the expiration date, unexercised warrants will become void.
Holders of the warrants may
exercise the warrants by delivering the warrant certificate representing the warrants to be exercised together with specified information,
and paying the required amount to the warrant agent in immediately available funds, as provided in the applicable prospectus supplement.
We will set forth on the reverse side of the warrant certificate and in the applicable prospectus supplement the information that the
holder of the warrant will be required to deliver to us or the warrant agent as applicable.
Upon receipt of the required
payment and the warrant certificate properly completed and duly executed at the corporate trust office of the warrant agent or any other
office indicated in the applicable prospectus supplement, we will issue and deliver the securities purchasable upon such exercise. If
fewer than all of the warrants represented by the warrant certificate are exercised, then we will issue a new warrant certificate for
the remaining amount of warrants. If we so indicate in the applicable prospectus supplement, holders of the warrants may surrender securities
as all or part of the exercise price for warrants.
Enforceability of Rights by Holders of Warrants
If selected, each warrant
agent will act solely as our agent under the applicable warrant agreement and will not assume any obligation or relationship of agency
or trust with any holder of any warrant. A single bank or trust company may act as warrant agent for more than one issue of warrants.
A warrant agent will have no duty or responsibility in case of any default by us under the applicable warrant agreement or warrant, including
any duty or responsibility to initiate any proceedings at law or otherwise, or to make any demand upon us. Any holder of a warrant may,
without the consent of the related warrant agent or the holder of any other warrant, enforce by appropriate legal action its right to
exercise, and receive the securities purchasable upon exercise of, its warrants.
DESCRIPTION OF RIGHTS
General
We may issue rights to our
stockholders to purchase shares of our common stock, preferred stock or the other securities described in this prospectus. We may offer
rights separately or together with one or more additional rights, debt securities, preferred stock, common stock or warrants, or any
combination of those securities in the form of units, as described in the applicable prospectus supplement. Each series of rights will
be issued under a separate rights agreement to be entered into between us and a bank or trust company, as rights agent. The rights agent
will act solely as our agent in connection with the certificates relating to the rights of the series of certificates and will not assume
any obligation or relationship of agency or trust for or with any holders of rights certificates or beneficial owners of rights. The
following description sets forth certain general terms and provisions of the rights to which any prospectus supplement may relate. The
particular terms of the rights to which any prospectus supplement may relate and the extent, if any, to which the general provisions
may apply to the rights so offered will be described in the applicable prospectus supplement. To the extent that any particular terms
of the rights, rights agreement or rights certificates described in a prospectus supplement differ from any of the terms described below,
then the terms described below will be deemed to have been superseded by that prospectus supplement. We encourage you to read the applicable
rights agreement and rights certificate for additional information before you decide whether to purchase any of our rights. We will provide
in a prospectus supplement the following terms of the rights being issued:
| ● | the
date of determining the stockholders entitled to the rights distribution; |
| ● | the
aggregate number of shares of common stock, preferred stock or other securities purchasable
upon exercise of the rights; |
| ● | the
aggregate number of rights issued; |
| ● | whether
the rights are transferrable and the date, if any, on and after which the rights may be separately
transferred; |
| ● | the
date on which the right to exercise the rights will commence, and the date on which the right
to exercise the rights will expire; |
| ● | the
method by which holders of rights will be entitled to exercise; |
| ● | the
conditions to the completion of the offering, if any; |
| ● | the
withdrawal, termination and cancellation rights, if any; |
| ● | whether
there are any backstop or standby purchaser or purchasers and the terms of their commitment,
if any; |
| ● | whether
stockholders are entitled to oversubscription rights, if any; |
| ● | any
applicable material U.S. federal income tax considerations; and |
| ● | any
other terms of the rights, including terms, procedures and limitations relating to the distribution,
exchange and exercise of the rights, as applicable. |
Each right will entitle the
holder of rights to purchase for cash the principal amount of shares of common stock, preferred stock or other securities at the exercise
price provided in the applicable prospectus supplement. Rights may be exercised at any time up to the close of business on the expiration
date for the rights provided in the applicable prospectus supplement.
Holders may exercise rights
as described in the applicable prospectus supplement. Upon receipt of payment and the rights certificate properly completed and duly
executed at the corporate trust office of the rights agent or any other office indicated in the prospectus supplement, we will, as soon
as practicable, forward the shares of common stock, preferred stock or other securities, as applicable, purchasable upon exercise of
the rights. If less than all of the rights issued in any rights offering are exercised, we may offer any unsubscribed securities directly
to persons other than stockholders, to or through agents, underwriters or dealers or through a combination of such methods, including
pursuant to standby arrangements, as described in the applicable prospectus supplement.
Rights Agent
The rights agent for any
rights we offer will be set forth in the applicable prospectus supplement.
DESCRIPTION OF UNITS
The following description,
together with the additional information we may include in any applicable prospectus supplements and free writing prospectuses, summarizes
the material terms and provisions of the units that we may offer under this prospectus.
While the terms we have summarized
below will apply generally to any units that we may offer under this prospectus, we will describe the particular terms of any series
of units in more detail in the applicable prospectus supplement. The terms of any units offered under a prospectus supplement may differ
from the terms described below. However, no prospectus supplement will fundamentally change the terms that are set forth in this prospectus
or offer a security that is not registered and described in this prospectus at the time of its effectiveness.
We will file as exhibits
to the registration statement of which this prospectus is a part, or will incorporate by reference from a Current Report on Form 8-K
that we file with the SEC, the form of unit agreement that describes the terms of the series of units we are offering, and any supplemental
agreements, before the issuance of the related series of units. The following summaries of material terms and provisions of the units
are subject to, and qualified in their entirety by reference to, all the provisions of the unit agreement and any supplemental agreements
applicable to a particular series of units. We urge you to read the applicable prospectus supplements related to the particular series
of units that we sell under this prospectus, as well as the complete unit agreement and any supplemental agreements that contain the
terms of the units.
General
We may issue units comprised
of one or more debt securities, shares of common stock, shares of preferred stock and warrants in any combination. Each unit will be
issued so that the holder of the unit is also the holder of each security included in the unit. Thus, the holder of a unit will have
the rights and obligations of a holder of each included security. The unit agreement under which a unit is issued may provide that the
securities included in the unit may not be held or transferred separately, at any time or at any time before a specified date.
We will describe in the applicable
prospectus supplement the terms of the series of units, including:
| ● | the
designation and terms of the units and of the securities comprising the units, including
whether and under what circumstances those securities may be held or transferred separately; |
| ● | any
provisions of the governing unit agreement that differ from those described below; and |
| ● | any
provisions for the issuance, payment, settlement, transfer or exchange of the units or of
the securities comprising the units. |
The provisions described
in this section, as well as those described under “Description of Capital Stock,” “Description of Debt Securities”
and “Description of Warrants” will apply to each unit and to any common stock, preferred stock, debt security or warrant
included in each unit, respectively.
Unit Agent
The name and address of the unit agent, if any,
for any units we offer will be set forth in the applicable prospectus supplement.
Issuance in Series
We may issue units in such
amounts and in numerous distinct series as we determine.
Enforceability of Rights by Holders of Units
Each unit agent will act
solely as our agent under the applicable unit agreement and will not assume any obligation or relationship of agency or trust with any
holder of any unit. A single bank or trust company may act as unit agent for more than one series of units. A unit agent will have no
duty or responsibility in case of any default by us under the applicable unit agreement or unit, including any duty or responsibility
to initiate any proceedings at law or otherwise, or to make any demand upon us. Any holder of a unit may, without the consent of the
related unit agent or the holder of any other unit, enforce by appropriate legal action its rights as holder under any security included
in the unit.
We, the unit agents and any
of their agents may treat the registered holder of any unit certificate as an absolute owner of the units evidenced by that certificate
for any purpose and as the person entitled to exercise the rights attaching to the units so requested, despite any notice to the contrary.
See “Legal Ownership of Securities.”
LEGAL OWNERSHIP OF SECURITIES
We can issue securities in
registered form or in the form of one or more global securities. We describe global securities in greater detail below. We refer to those
persons who have securities registered in their own names on the books that we or any applicable trustee or depositary or warrant agent
maintain for this purpose as the “holders” of those securities. These persons are the legal holders of the securities. We
refer to those persons who, indirectly through others, own beneficial interests in securities that are not registered in their own names,
as “indirect holders” of those securities. As we discuss below, indirect holders are not legal holders, and investors in
securities issued in book-entry form or in street name will be indirect holders.
Book-Entry Holders
We may issue securities in
book-entry form only, as we will specify in the applicable prospectus supplement. This means securities may be represented by one or
more global securities registered in the name of a financial institution that holds them as depositary on behalf of other financial institutions
that participate in the depositary’s book-entry system. These participating institutions, which are referred to as participants,
in turn, hold beneficial interests in the securities on behalf of themselves or their customers.
Only the person in whose
name a security is registered is recognized as the holder of that security. Global securities will be registered in the name of the depositary
or its participants. Consequently, for global securities, we will recognize only the depositary as the holder of the securities, and
we will make all payments on the securities to the depositary. The depositary passes along the payments it receives to its participants,
which in turn pass the payments along to their customers who are the beneficial owners. The depositary and its participants do so under
agreements they have made with one another or with their customers; they are not obligated to do so under the terms of the securities.
As a result, investors in
a global security will not own securities directly. Instead, they will own beneficial interests in a global security, through a bank,
broker or other financial institution that participates in the depositary’s book-entry system or holds an interest through a participant.
As long as the securities are issued in global form, investors will be indirect holders, and not legal holders, of the securities.
Street Name Holders
We may terminate a global
security or issue securities that are not issued in global form. In these cases, investors may choose to hold their securities in their
own names or in “street name.” Securities held by an investor in street name would be registered in the name of a bank, broker
or other financial institution that the investor chooses, and the investor would hold only a beneficial interest in those securities
through an account he or she maintains at that institution.
For securities held in street
name, we or any applicable trustee or depositary will recognize only the intermediary banks, brokers and other financial institutions
in whose names the securities are registered as the holders of those securities, and we or any such trustee or depositary will make all
payments on those securities to them. These institutions pass along the payments they receive to their customers who are the beneficial
owners, but only because they agree to do so in their customer agreements or because they are legally required to do so. Investors who
hold securities in street name will be indirect holders, not legal holders, of those securities.
Legal Holders
Our obligations, as well
as the obligations of any applicable trustee or third party employed by us or a trustee, run only to the legal holders of the securities.
We do not have obligations to investors who hold beneficial interests in global securities, in street name or by any other indirect means.
This will be the case whether an investor chooses to be an indirect holder of a security or has no choice because we are issuing the
securities only in global form.
For example, once we make
a payment or give a notice to the holder, we have no further responsibility for the payment or notice even if that holder is required,
under agreements with its participants or customers or by law, to pass it along to the indirect holders but does not do so. Similarly,
we may want to obtain the approval of the holders to amend an indenture, to relieve us of the consequences of a default or of our obligation
to comply with a particular provision of an indenture, or for other purposes. In such an event, we would seek approval only from the
legal holders, and not the indirect holders, of the securities. Whether and how the legal holders contact the indirect holders is up
to the legal holders.
Special Considerations for Indirect Holders
If you hold securities through
a bank, broker or other financial institution, either in book-entry form because the securities are represented by one or more global
securities or in street name, you should check with your own institution to find out:
| ● | how
it handles securities payments and notices; |
| ● | whether
it imposes fees or charges; |
| ● | how
it would handle a request for the holders’ consent, if ever required; |
| ● | whether
and how you can instruct it to send you securities registered in your own name so you can
be a legal holder, if that is permitted in the future; |
| ● | how
it would exercise rights under the securities if there were a default or other event triggering
the need for holders to act to protect their interests; and |
| ● | if
the securities are in book-entry form, how the depositary’s rules and procedures
will affect these matters. |
Global Securities
A global security is a security
that represents one or any other number of individual securities held by a depositary. Generally, all securities represented by the same
global securities will have the same terms.
Each security issued in book-entry
form will be represented by a global security that we issue to, deposit with and register in the name of a financial institution or its
nominee that we select. The financial institution that we select for this purpose is called the depositary. Unless we specify otherwise
in the applicable prospectus supplement, The Depository Trust Company, New York, NY, known as “DTC”, will be the depositary
for all securities issued in book-entry form.
A global security may not
be transferred to or registered in the name of anyone other than the depositary, its nominee or a successor depositary, unless special
termination situations arise. We describe those situations below under “— Special Situations When A Global Security
Will Be Terminated.” As a result of these arrangements, the depositary, or its nominee, will be the sole registered owner and
legal holder of all securities represented by a global security, and investors will be permitted to own only beneficial interests in
a global security. Beneficial interests must be held by means of an account with a broker, bank or other financial institution that in
turn has an account with the depositary or with another institution that does. Thus, an investor whose security is represented by a global
security will not be a legal holder of the security, but only an indirect holder of a beneficial interest in the global security.
If the prospectus supplement
for a particular security indicates that the security will be issued as a global security, then the security will be represented by a
global security at all times unless and until the global security is terminated. If termination occurs, we may issue the securities through
another book-entry clearing system or decide that the securities may no longer be held through any book-entry clearing system.
Special Considerations For Global Securities
As an indirect holder, an
investor’s rights relating to a global security will be governed by the account rules of the investor’s financial institution
and of the depositary, as well as general laws relating to securities transfers. We do not recognize an indirect holder as a holder of
securities and instead deal only with the depositary that holds the global security.
If securities are issued
only as global securities, an investor should be aware of the following:
| ● | an
investor cannot cause the securities to be registered in his or her name, and cannot obtain
non-global certificates for his or her interest in the securities, except in the special
situations we describe below; |
| ● | an
investor will be an indirect holder and must look to his or her own bank or broker for payments
on the securities and protection of his or her legal rights relating to the securities, as
we describe above; |
| ● | an
investor may not be able to sell interests in the securities to some insurance companies
and to other institutions that are required by law to own their securities in non-book-entry
form; |
| ● | an
investor may not be able to pledge his or her interest in the global security in circumstances
where certificates representing the securities must be delivered to the lender or other beneficiary
of the pledge in order for the pledge to be effective; |
| ● | the
depositary’s policies, which may change from time to time, will govern payments, transfers,
exchanges and other matters relating to an investor’s interest in the global security.
We and any applicable trustee have no responsibility for any aspect of the depositary’s
actions or for its records of ownership interests in the global security. We and the trustee
also do not supervise the depositary in any way; |
| ● | the
depositary may, and we understand that DTC will, require that those who purchase and sell
interests in the global security within its book-entry system use immediately available funds,
and your broker or bank may require you to do so as well; and |
| ● | financial
institutions that participate in the depositary’s book-entry system, and through which
an investor holds its interest in the global security, may also have their own policies affecting
payments, notices and other matters relating to the securities. There may be more than one
financial intermediary in the chain of ownership for an investor. We do not monitor and are
not responsible for the actions of any of those intermediaries. |
Special Situations When A Global Security
Will Be Terminated
In a few special situations
described below, a global security will terminate and interests in it will be exchanged for physical certificates representing those
interests. After that exchange, the choice of whether to hold securities directly or in street name will be up to the investor. Investors
must consult their own banks or brokers to find out how to have their interests in securities transferred to their own names, so that
they will be direct holders. We have described the rights of holders and street name investors above.
A global security will terminate
when the following special situations occur:
| ● | if
the depositary notifies us that it is unwilling, unable or no longer qualified to continue
as depositary for that global security and we do not appoint another institution to act as
depositary within 90 days; |
| ● | if
we notify any applicable trustee that we wish to terminate that global security; or |
| ● | if
an event of default has occurred with regard to securities represented by that global security
and has not been cured or waived. |
The applicable prospectus
supplement may also list additional situations for terminating a global security that would apply only to the particular series of securities
covered by the prospectus supplement. When a global security terminates, the depositary, and neither we, nor any applicable trustee,
is responsible for deciding the names of the institutions that will be the initial direct holders.
PLAN OF DISTRIBUTION
We may sell the securities being offered hereby
in one or more of the following ways from time to time:
| ● | through
agents to the public or to investors; |
| ● | to
underwriters for resale to the public or to investors; |
| ● | negotiated
transactions; |
| ● | directly
to investors; or |
| ● | through
a combination of any of these methods of sale. |
As set forth in more detail below, the securities
may be distributed from time to time in one or more transactions:
| ● | at
a fixed price or prices, which may be changed; |
| ● | at
market prices prevailing at the time of sale; |
| ● | at
prices related to such prevailing market prices; or |
We will set forth in a prospectus supplement
the terms of that particular offering of securities, including:
| ● | the
name or names of any agents or underwriters; |
| ● | the
purchase price of the securities being offered and the proceeds we will receive from the
sale; |
| ● | any
over-allotment options under which underwriters may purchase additional securities from us; |
| ● | any
agency fees or underwriting discounts and other items constituting agents’ or underwriters’
compensation; |
| ● | any
initial public offering price; |
| ● | any
discounts or concessions allowed or re-allowed or paid to dealers; and |
| ● | any
securities exchanges or markets on which such securities may be listed. |
Only underwriters named in
an applicable prospectus supplement are underwriters of the securities offered by that prospectus supplement.
If underwriters are used
in an offering, we will execute an underwriting agreement with such underwriters and will specify the name of each underwriter and the
terms of the transaction (including any underwriting discounts and other terms constituting compensation of the underwriters and any
dealers) in a prospectus supplement. The securities may be offered to the public either through underwriting syndicates represented by
managing underwriters or directly by one or more investment banking firms or others, as designated. If an underwriting syndicate is used,
the managing underwriter(s) will be specified on the cover of the prospectus supplement. If underwriters are used in the sale, the
offered securities will be acquired by the underwriters for their own accounts and may be resold from time to time in one or more transactions,
including negotiated transactions, at a fixed public offering price or at varying prices determined at the time of sale. Any public offering
price and any discounts or concessions allowed or re-allowed or paid to dealers may be changed from time to time. Unless otherwise set forth
in the prospectus supplement, the obligations of the underwriters to purchase the offered securities will be subject to conditions precedent
and the underwriters will be obligated to purchase all of the offered securities if any are purchased.
We may grant to the underwriters
options to purchase additional securities to cover over-allotments, if any, at the public offering price, with additional underwriting
commissions or discounts, as may be set forth in a related prospectus supplement. The terms of any over-allotment option will be set
forth in the prospectus supplement for those securities.
If we use a dealer in the
sale of the securities being offered pursuant to this prospectus or any prospectus supplement, we will sell the securities to the dealer,
as principal. The dealer may then resell the securities to the public at varying prices to be determined by the dealer at the time of
resale. The names of the dealers and the terms of the transaction will be specified in a prospectus supplement.
We may sell the securities
directly or through agents we designate from time to time. We will name any agent involved in the offering and sale of securities and
we will describe any commissions we will pay the agent in the prospectus supplement. Unless the prospectus supplement states otherwise,
any agent will act on a best-efforts basis for the period of its appointment.
We may authorize agents or
underwriters to solicit offers by institutional investors to purchase securities from us at the public offering price set forth in the
prospectus supplement pursuant to delayed delivery contracts providing for payment and delivery on a specified date in the future. We
will describe the conditions to these contracts and the commissions we must pay for solicitation of these contracts in the prospectus
supplement.
In connection with the sale
of the securities, underwriters, dealers or agents may receive compensation from us or from purchasers of the common stock for whom they
act as agents in the form of discounts, concessions or commissions. Underwriters may sell the securities to or through dealers, and those
dealers may receive compensation in the form of discounts, concessions or commissions from the underwriters or commissions from the purchasers
for whom they may act as agents. Underwriters, dealers and agents that participate in the distribution of the securities, and any institutional
investors or others that purchase common stock directly and then resell the securities, may be deemed to be underwriters, and any discounts
or commissions received by them from us and any profit on the resale of the common stock by them may be deemed to be underwriting discounts
and commissions under the Securities Act.
We may provide agents and
underwriters with indemnification against particular civil liabilities, including liabilities under the Securities Act, or contribution
with respect to payments that the agents or underwriters may make with respect to such liabilities. Agents and underwriters may engage
in transactions with, or perform services for, us in the ordinary course of business.
We may engage in at the market
offerings into an existing trading market in accordance with Rule 415(a)(4) under the Securities Act. In addition, we may enter into
derivative transactions with third parties (including the writing of options), or sell securities not covered by this prospectus to third
parties in privately negotiated transactions. If the applicable prospectus supplement indicates, in connection with such a transaction,
the third parties may, pursuant to this prospectus and the applicable prospectus supplement, sell securities covered by this prospectus
and the applicable prospectus supplement. If so, the third party may use securities borrowed from us or others to settle such sales and
may use securities received from us to close out any related short positions. We may also loan or pledge securities covered by this prospectus
and the applicable prospectus supplement to third parties, who may sell the loaned securities or, in an event of default in the case
of a pledge, sell the pledged securities pursuant to this prospectus and the applicable prospectus supplement. The third party in such
sale transactions will be an underwriter and will be identified in the applicable prospectus supplement or in a post-effective amendment.
To facilitate an offering
of a series of securities, persons participating in the offering may engage in transactions that stabilize, maintain, or otherwise affect
the market price of the securities. This may include over-allotments or short sales of the securities, which involves the sale by persons
participating in the offering of more securities than have been sold to them by us. In those circumstances, such persons would cover
such over-allotments or short positions by purchasing in the open market or by exercising the over-allotment option granted to those
persons. In addition, those persons may stabilize or maintain the price of the securities by bidding for or purchasing securities in
the open market or by imposing penalty bids, whereby selling concessions allowed to underwriters or dealers participating in any such
offering may be reclaimed if securities sold by them are repurchased in connection with stabilization transactions. The effect of these
transactions may be to stabilize or maintain the market price of the securities at a level above that which might otherwise prevail in
the open market. Such transactions, if commenced, may be discontinued at any time. We make no representation or prediction as to the
direction or magnitude of any effect that the transactions described above, if implemented, may have on the price of our securities.
Unless otherwise specified
in the applicable prospectus supplement, each class or series of securities will be a new issue with no established trading market, other
than our common stock, which is listed on The Nasdaq Capital Market. We may elect to list any other class or series of securities on
any exchange or market, but we are not obligated to do so. It is possible that one or more underwriters may make a market in a class
or series of securities, but the underwriters will not be obligated to do so and may discontinue any market making at any time without
notice. We cannot give any assurance as to the liquidity of the trading market for any of the securities.
In order to comply with the
securities laws of some U.S. states or territories, if applicable, the securities offered pursuant to this prospectus will be sold in
those states only through registered or licensed brokers or dealers. In addition, in some states securities may not be sold unless they
have been registered or qualified for sale in the applicable state or an exemption from the registration or qualification requirement
is available and complied with.
Any underwriter may engage
in overallotment, stabilizing transactions, short covering transactions and penalty bids in accordance with Regulation M under the Exchange
Act. Overallotment involves sales in excess of the offering size, which create a short position. Stabilizing transactions permit bids
to purchase the underlying security so long as the stabilizing bids do not exceed a specified maximum. Short covering transactions involve
purchases of the securities in the open market after the distribution is completed to cover short positions. Penalty bids permit the
underwriters to reclaim a selling concession from a dealer when the securities originally sold by the dealer are purchased in a covering
transaction to cover short positions. Those activities may cause the price of the securities to be higher than it would otherwise be.
If commenced, the underwriters may discontinue any of these activities at any time.
Any underwriters who are
qualified market makers on The Nasdaq Capital Market may engage in passive market making transactions in the securities on The Nasdaq
Capital Market in accordance with Rule 103 of Regulation M, during the business day prior to the pricing of the offering, before
the commencement of offers or sales of the securities. Passive market makers must comply with applicable volume and price limitations
and must be identified as passive market makers. In general, a passive market maker must display its bid at a price not in excess of
the highest independent bid for such security. If all independent bids are lowered below the passive market maker’s bid, however,
the passive market maker’s bid must then be lowered when certain purchase limits are exceeded.
LEGAL MATTERS
Sheppard, Mullin, Richter
& Hampton LLP, New York, New York, will pass upon the validity of the shares of our common stock offered hereby. Additional legal
matters may be passed upon for us or any underwriters, dealers or agents, by counsel that we will name in the applicable prospectus supplement.
EXPERTS
dbbmckennon,
an independent registered public accounting firm, has audited our financial statements included in our Annual Report on Form 10-K for
the year ended December 31, 2023, as set forth in their report, which includes an explanatory paragraph as to our ability to continue
as a going concern, dated April 16, 2024, which is incorporated by reference in this prospectus and elsewhere in the registration statement,
given on the authority of such firm as experts in accounting and auditing.
The consolidated financial statements
of Evofem Biosciences, Inc. as of and for the year ended December 31, 2023 incorporated by reference in this Registration Statement of
Aditxt, Inc., have been audited by BPM LLP, an independent registered public accounting firm, as stated in their report (which contains
an explanatory paragraph relating to substantial doubt about the ability of Evofem Biosciences, Inc. to continue as a going concern as
described in Note 1 to the consolidated financial statements) which is also incorporated by reference herein. Such consolidated financial
statements have been so incorporated by reliance herein in reliance on the report of such firm given on the authority of said firm as
experts in auditing and accounting.
The
financial statements of Evofem Biosciences, Inc. and subsidiaries as of December 31, 2022, and for the year ended December 31, 2022,
incorporated by reference in this Prospectus, have been audited by Deloitte & Touche LLP, an independent registered public accounting
firm, as stated in their report. Such financial statements are incorporated by reference in reliance upon the report of such firm given
their authority as experts in accounting and auditing.
The audited historical financial
statements of Appili Therapeutics Inc. which appears in Aditxt, Inc.’s Current Report on Form 8-K filed on August 1, 2024 have
been so incorporated in reliance on the report of PricewaterhouseCoopers LLP, independent auditors, given on the authority of said firm
as experts in auditing and accounting.
WHERE YOU CAN FIND MORE
INFORMATION
This prospectus constitutes
a part of a registration statement on Form S-3 filed under the Securities Act. As permitted by the SEC’s rules, this prospectus
and any prospectus supplement, which form a part of the registration statement, do not contain all the information that is included
in the registration statement. For further information with respect to us and our securities, we refer you to the registration statement,
including the exhibits filed as a part of the registration statement. Statements contained in this prospectus concerning the contents
of any contract or any other document is not necessarily complete. If a contract or document has been filed as an exhibit to the registration
statement, please see the copy of the contract or document that has been filed. Each statement is this prospectus relating to a contract
or document filed as an exhibit is qualified in all respects by the filed exhibit. We are subject to the informational requirements of
the Exchange Act and in accordance therewith file annual, quarterly and current reports, proxy statements and other information with
the SEC. The SEC maintains an Internet website that contains reports, proxy statements and other information about issuers, like us,
that file electronically with the SEC. The address of that website is www.sec.gov. The registration statement and the
documents referred to below under “Incorporation of Documents By Reference” are also available on our website, www.aditxt.com.
We have not incorporated by reference into this prospectus the information on our website, and you should not consider it to be a part
of this prospectus.
INCORPORATION OF DOCUMENTS
BY REFERENCE
We have filed a registration
statement on Form S-3 with the SEC under the Securities Act. This prospectus is part of the registration statement, however the
registration statement includes and incorporates by reference additional information and exhibits. The SEC permits us to “incorporate
by reference” the information contained in documents we file with the SEC, which means that we can disclose important information
to you by referring you to those documents rather than by including them in this prospectus. Information that is incorporated by reference
is considered to be part of this prospectus and you should read it with the same care that you read this prospectus. Information that
we file later with the SEC will automatically update and supersede the information that is either contained, or incorporated by reference,
in this prospectus, and will be considered to be a part of this prospectus from the date those documents are filed. We have filed with
the SEC, and incorporate by reference in this prospectus:
|
● |
Current Reports on Form 8-K, filed with the SEC on
January 2, 2024, January
5, 2024, January 5, 2024,
January 9, 2024, January
19, 2024, January 30, 2024,
January 30, 2024, February
2, 2024, February 6, 2024,
February 9, 2024, February
15, 2024, February 16, 2024,
February 21, 2024, February
22, 2024, February 29, 2024,
March 1, 2024, March
4, 2024, March 11, 2024,
April 4, 2024 (as
amended on August 1, 2024), April
12, 2024, May 3, 2024
(as amended May 3, 2024),
May 7, 2024, May
8, 2024, May 13, 2024,
May 22, 2023, May
28, 2024, June 12, 2024,
June 21, 2024, June
25, 2024, July 8, 2024,
July 9, 2024, July
18, 2024, July 22, 2024,
and August 1, 2024 (originally filed on December 12, 2023); |
|
● |
Annual Report on Form
10-K for the year ended December 31, 2023 filed with the SEC on April 16, 2024; |
|
● |
Quarterly Report on Form
10-Q for the three months ended March 31, 2024 filed with the SEC on May 20, 2024; |
|
● |
Proxy Statement on Schedule
14A filed on July 5, 2024; and |
|
● |
the description of our common stock and our preferred
stock contained in our Registration Statement on Form 8-A12B/A
filed with the SEC on June 17, 2020, and any amendments or reports filed updating such description. |
In addition, all documents
subsequently filed by us pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act, prior to the termination of the offering
(excluding any information furnished rather than filed) shall be deemed to be incorporated by reference into this prospectus.
Notwithstanding the statements
in the preceding paragraphs, no document, report or exhibit (or portion of any of the foregoing) or any other information that we have
“furnished” to the SEC pursuant to the Exchange Act shall be incorporated by reference into this prospectus.
We will furnish without charge
to you, on written or oral request, a copy of any or all of the documents incorporated by reference in this prospectus, including exhibits
to these documents. You should direct any requests for documents to:
Aditxt, Inc.
2569 Wyandotte Street, Suite 101
Mountain View, CA 94043
Phone: (650) 870-1200
You also may access these
filings on our website at http://www.aditxt.com. We do not incorporate the information on our website into this prospectus or any supplement
to this prospectus and you should not consider any information on, or that can be accessed through, our website as part of this prospectus
or any supplement to this prospectus (other than those filings with the SEC that we specifically incorporate by reference into this prospectus
or any supplement to this prospectus).
Any statement contained in
a document incorporated or deemed to be incorporated by reference in this prospectus will be deemed modified, superseded or replaced
for purposes of this prospectus to the extent that a statement contained in this prospectus modifies, supersedes or replaces such statement.
Any statement contained herein or in any document incorporated or deemed to be incorporated by reference shall be deemed to be modified
or superseded for purposes of the registration statement of which this prospectus forms a part to the extent that a statement contained
in any other subsequently filed document which also is or is deemed to be incorporated by reference modifies or supersedes such statement.
Any such statement so modified or superseded shall not be deemed to constitute a part of the registration statement of which this prospectus
forms a part, except as so modified or superseded.
Aditxt, Inc.
677,208 Shares of Common Stock
Pre-Funded Warrants to Purchase 3,366,297 Shares
of Common Stock
(and the shares of Common Stock underlying the
Pre-Funded Warrants)
PROSPECTUS SUPPLEMENT
September 29, 2024
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