CELZ Creative Medical Technology Holdings Inc

Creative Medical Technology Holdings, Inc. (NASDAQ: CELZ), a clinical-stage biotechnology company advancing regenerative medicine solutions, today announced promising one-year follow-up data from the AlloStem ™ (CELZ-201) Type 2 Diabetes pilot study for late-stage patients. CELZ-201 is an off the shelf, ready-to-use universal and proprietary allogenic (donor) cell line developed by the Company.

Results demonstrate that CELZ-201 achieved an 80% overall efficacy rate in reducing insulin dependency and stabilizing hemoglobin A1c levels, with no serious adverse effects reported.

The study, which included 20 patients—10 receiving CELZ-201 and 10 undergoing optimized medical therapy—validated the safety and efficacy of CELZ-201 through the same infusion procedure used in the Company’s U.S. FDA-cleared Type 1 Diabetes clinical trial, which is currently underway. The absence of safety concerns further supports the potential of CELZ-201 as a breakthrough treatment for late-stage Type 2 Diabetes.

Given these compelling results, Creative Medical Technology plans to advance the development of AlloStem (CELZ-201) for the treatment of late-stage Type 2 Diabetes and explore other potential applications of this therapy to expand the Company’s pipeline.

"The positive one-year data from the study represents a significant milestone in our mission to revolutionize diabetes treatment and help a wide variety of patients who potentially may not benefit from autologous therapies," said Timothy Warbington, President and CEO of Creative Medical Technology. "With a diversified portfolio that includes CELZ-201 for early-stage Type 1 Diabetes, CELZ-101 for brittle Type 1 Diabetes, and CELZ-201 for late-stage Type 2 Diabetes, we are committed to delivering innovative solutions that transform patient care."

About Type 2 Diabetes*Type 2 diabetes affects approximately 90-95% of the 38 million Americans diagnosed with diabetes. While initially managed through diet, exercise, and oral medications, many patients eventually require insulin therapy as the disease progresses. Diabetes remains the eighth leading cause of death in the U.S., with over 96 million adults classified as prediabetic—more than 80% of whom are unaware of their condition.

*https://www.cdc.gov/diabetes/about/about-type-2-diabetes.html

About Creative Medical Technology Holdings, Inc.Creative Medical Technology Holdings, Inc. is a clinical-stage biotechnology company dedicated to developing groundbreaking regenerative cell therapies. The company’s pipeline targets a range of conditions, with a focus on endocrinology, immunotherapy, orthopedic and neurological diseases. For more information, visit www.creativemedicaltechnology.com.

Forward Looking StatementsThis news release may contain forward-looking statements including but not limited to comments regarding the timing and content of upcoming clinical trials and laboratory results, marketing efforts, funding, etc. Forward-looking statements address future events and conditions and, therefore, involve inherent risks and uncertainties. Actual results may differ materially from those currently anticipated in such statements. See the periodic and other reports filed by Creative Medical Technology Holdings, Inc. with the Securities and Exchange Commission and available on the Commission's website at www.sec.gov.

Contact:Creative Medical Technology Holdings, Inc.IR@CreativeMedicalTechnology.com

Investor Relations:Devin Sullivan, Managing DirectorThe Equity Group Inc.dsullivan@equityny.com