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| Date | Nom du détenteur | Actions transigées | Fourchette de valeur ($) | Type d'opération | Fourchette de prix ($) | Actions en fin de déclaration | % de variation |
|---|---|---|---|---|---|---|---|
| 2026-05-22 | Mr. Michael Alexander SmithChief Legal Officer & Corporate Secretary | -6,15k | 666,98k | Automatic Disposition | 108,47 | 41,61k | -12,87% |
| 2026-05-18 | Mr. William H. LewisPresident, CEO & Chairman | -14,87k | 1,59M | Automatic Disposition | 106,39 - 106,97 | 506,96k | -2,85% |
| 2026-05-18 | Mr. William H. LewisPresident, CEO & Chairman | -10,70k | 865,27k | Derivative Exercise and Sale | 17,16 - 106,39 | 506,96k | - |
| 2026-05-13 | Ms. Sara M. BonsteinCFO | -8,27k | 961,04k | Vente | 116,18 | 24,01k | -25,62% |
| 2026-05-13 | Mr. Roger AdsettCOO | -5,84k | 678,14k | Vente | 116,18 | 59,96k | -8,87% |
| 2026-05-14 | Dr. Martina FlammerChief Medical Officer | -10,48k | 1,23M | Automatic Disposition | 117,54 | 64,91k | -13,90% |
| 2026-05-13 | Dr. Martina FlammerChief Medical Officer | -7,85k | 897,19k | Vente | 112,76 - 116,18 | 64,91k | -10,79% |
| 2026-05-13 | Mr. Michael Alexander SmithChief Legal Officer & Corporate Secretary | -4,11k | 477,38k | Vente | 116,18 | 47,76k | -7,92% |
| 2026-05-13 | Mr. William H. LewisPresident, CEO & Chairman | -13,28k | 1,54M | Vente | 116,18 | 521,83k | -2,48% |
| 2026-05-11 | Dr. Martina FlammerChief Medical Officer | -12,95k | 1,08M | Derivative Exercise and Sale | 17,07 - 101,18 | 32,96k | - |
| 2026-05-04 | Mr. William H. LewisPresident, CEO & Chairman | -10,70k | 1,20M | Derivative Exercise and Sale | 17,16 - 139,60 | 359,48k | - |
| 2026-04-16 | Mr. William H. LewisPresident, CEO & Chairman | -10,70k | 1,27M | Derivative Exercise and Sale | 17,16 - 145,79 | 359,48k | - |
| 2026-04-06 | Mr. William H. LewisPresident, CEO & Chairman | -10,70k | 1,48M | Derivative Exercise and Sale | 17,16 - 164,01 | 359,48k | - |
| 2026-04-01 | Mr. Roger AdsettCOO | -88,06k | 13,22M | Derivative Exercise and Sale | 14,56 - 164,95 | 47,39k | - |
| 2026-03-30 | Mr. Michael Alexander SmithChief Legal Officer & Corporate Secretary | -19,64k | 2,48M | Derivative Exercise and Sale | 17,07 - 150,98 | 51,87k | - |
| 2026-03-19 | Mr. William H. LewisPresident, CEO & Chairman | -10,70k | 1,27M | Derivative Exercise and Sale | 17,16 - 144,11 | 359,48k | - |
| 2026-03-05 | Mr. William H. LewisPresident, CEO & Chairman | -10,70k | 1,30M | Derivative Exercise and Sale | 17,16 - 147,54 | 359,48k | - |
| 2026-03-03 | Dr. Melvin SharokyIndependent Director | -100,00 | 0,00 | Other Disposition | - | 264,54k | -0,04% |
| 2026-02-25 | Dr. Melvin SharokyIndependent Director | -1,07k | 0,00 | Other Disposition | - | 264,64k | -0,40% |
| 2026-02-24 | Mr. Michael Alexander SmithChief Legal Officer & Corporate Secretary | -20,25k | 2,81M | Derivative Exercise and Sale | 17,07 - 156,53 | 51,87k | - |
| 2026-02-24 | Mr. Michael Alexander SmithChief Legal Officer & Corporate Secretary | -4,53k | 708,45k | Automatic Disposition | 156,53 | 51,87k | -8,03% |
| 2026-02-23 | Mr. David R. BrennanLead Independent Director | -6,00k | 0,00 | Other Disposition | - | 115,88k | -4,92% |
| 2026-02-19 | Mr. William H. LewisPresident, CEO & Chairman | -10,70k | 1,35M | Derivative Exercise and Sale | 17,16 - 153,38 | 409,98k | - |
| 2026-02-09 | Mr. David W. J. McGirrInitié | -53,40k | 0,00 | Other Disposition | - | 92,67k | -36,56% |
| 2026-02-09 | Mr. William H. LewisPresident, CEO & Chairman | -10,70k | 1,31M | Derivative Exercise and Sale | 17,16 - 148,02 | 409,98k | - |
| 2026-02-09 | Mr. William H. LewisPresident, CEO & Chairman | -2,70k | 400,25k | Automatic Disposition | 148,02 - 148,83 | 409,98k | -0,65% |
| 2026-02-05 | Dr. Martina FlammerChief Medical Officer | -869,00 | 132,47k | Automatic Disposition | 152,44 | 14,63k | -5,61% |
| 2026-02-03 | Mr. Roger AdsettCOO | -791,00 | 123,53k | Vente | 156,17 | 47,39k | -1,64% |
| 2026-02-03 | Ms. Sara M. BonsteinCFO | -748,00 | 116,94k | Vente | 156,34 | 8,01k | -8,54% |
| 2026-02-03 | Mr. William H. LewisPresident, CEO & Chairman | -3,01k | 470,43k | Vente | 156,34 | 412,68k | -0,72% |
| 2026-02-03 | Mr. Michael Alexander SmithChief Legal Officer & Corporate Secretary | -640,00 | 100,01k | Vente | 156,27 | 56,40k | -1,12% |
| 2026-02-02 | Dr. Martina FlammerChief Medical Officer | -7,98k | 709,38k | Derivative Exercise and Sale | 65,72 - 156,86 | 15,50k | - |
| 2026-02-03 | Dr. Martina FlammerChief Medical Officer | -795,00 | 123,84k | Vente | 155,77 | 15,50k | -4,88% |
| 2026-01-20 | Mr. William H. LewisPresident, CEO & Chairman | -10,70k | 1,43M | Derivative Exercise and Sale | 17,16 - 160,70 | 409,98k | - |
| 2026-01-12 | Mr. William H. LewisPresident, CEO & Chairman | -10,70k | 1,53M | Derivative Exercise and Sale | 17,16 - 168,63 | 415,69k | - |
| 2026-01-12 | Mr. William H. LewisPresident, CEO & Chairman | -8,52k | 1,45M | Automatic Disposition | 168,63 - 174,86 | 415,69k | -2,01% |
| 2026-01-09 | Dr. Martina FlammerChief Medical Officer | -1,89k | 351,34k | Automatic Disposition | 186,19 | 16,29k | -10,38% |
| 2026-01-06 | Mr. Roger AdsettCOO | -4,29k | 746,71k | Vente | 173,33 - 175,07 | 48,18k | -8,18% |
| 2026-01-06 | Ms. Sara M. BonsteinCFO | -4,64k | 808,73k | Vente | 173,33 - 175,07 | 8,76k | -34,64% |
| 2026-01-06 | Dr. Martina FlammerChief Medical Officer | -8,57k | 1,26M | Derivative Exercise and Sale | 26,43 - 175,01 | 18,18k | - |
| 2026-01-06 | Dr. Martina FlammerChief Medical Officer | -4,71k | 820,71k | Vente | 173,33 - 175,84 | 18,18k | -20,57% |
| 2026-01-08 | Dr. Martina FlammerChief Medical Officer | -3,25k | 566,23k | Automatic Disposition | 174,17 | 18,18k | -15,17% |
| 2026-01-06 | Mr. Michael Alexander SmithChief Legal Officer & Corporate Secretary | -3,16k | 549,49k | Vente | 173,33 - 175,07 | 57,04k | -5,25% |
| 2026-01-06 | Mr. William H. LewisPresident, CEO & Chairman | -9,68k | 1,68M | Vente | 173,33 - 175,07 | 424,21k | -2,23% |
| 2026-01-05 | Dr. Martina FlammerChief Medical Officer | -12,30k | 1,79M | Derivative Exercise and Sale | 19,74 - 175,73 | 20,93k | - |
| 2026-01-02 | Ms. S. Nicole SchaefferChief People Strategy Officer | -87,29k | 14,08M | Derivative Exercise and Sale | 13,91 - 177,78 | 41,75k | - |
| 2025-12-18 | Mr. William H. LewisPresident, CEO & Chairman | -10,70k | 1,52M | Derivative Exercise and Sale | 17,16 - 171,20 | 405,43k | - |
| 2025-12-05 | Dr. Melvin SharokyIndependent Director | -20,00k | 4,10M | Vente | 205,01 | 264,74k | -7,02% |
| 2025-12-04 | Mr. William H. LewisPresident, CEO & Chairman | -10,70k | 1,93M | Derivative Exercise and Sale | 17,16 - 207,42 | 405,43k | - |
| 2025-12-01 | Dr. Martina FlammerChief Medical Officer | -8,90k | 1,61M | Derivative Exercise and Sale | 25,83 - 207,73 | 14,63k | - |
| 2025-11-24 | Ms. Elizabeth McKee AndersonIndependent Director | -5,00k | 1,02M | Vente | 204,58 | 53,67k | -8,52% |
| 2025-11-17 | Mr. Leo LeeIndependent Director | -75,00k | 14,69M | Vente | 193,51 - 197,40 | 49,62k | -60,18% |
| 2025-11-14 | Ms. Elizabeth McKee AndersonIndependent Director | -10,00k | 1,96M | Vente | 195,87 | 58,67k | -14,56% |
| 2025-11-12 | Ms. S. Nicole SchaefferChief People Strategy Officer | -30,00k | 5,03M | Derivative Exercise and Sale | 26,46 - 195,88 | 36,46k | - |
| 2025-11-11 | Dr. Martina FlammerChief Medical Officer | -31,23k | 5,36M | Derivative Exercise and Sale | 17,07 - 191,04 | 14,63k | - |
| 2025-11-06 | Mr. David R. BrennanLead Independent Director | -60,00k | 0,00 | Other Disposition | - | 121,88k | -32,99% |
| 2025-11-03 | Mr. Michael Alexander SmithChief Legal Officer & Corporate Secretary | -27,13k | 4,34M | Derivative Exercise and Sale | 23,75 - 187,97 | 54,90k | - |
| 2025-09-12 | Ms. S. Nicole SchaefferChief People Strategy Officer | -56,52k | 6,86M | Derivative Exercise and Sale | 23,75 - 145,67 | 36,46k | - |
| 2025-09-12 | Ms. S. Nicole SchaefferChief People Strategy Officer | -20,00k | 2,93M | Automatic Disposition | 145,67 - 147,46 | 36,46k | -35,42% |
| 2025-09-12 | Dr. Melvin SharokyIndependent Director | -10,00k | 1,45M | Vente | 145,39 | 289,61k | -3,34% |
| 2025-09-11 | Dr. Melvin SharokyIndependent Director | -2,16k | 0,00 | Other Disposition | - | 289,61k | -0,74% |
| 2025-09-04 | Ms. S. Nicole SchaefferChief People Strategy Officer | -23,30k | 0,00 | Other Disposition | - | 3,96k | -85,47% |
| 2025-09-02 | Mr. Michael Alexander SmithChief Legal Officer & Corporate Secretary | -12,78k | 1,44M | Derivative Exercise and Sale | 30,46 - 144,16 | 54,90k | - |
| 2025-09-02 | Mr. Michael Alexander SmithChief Legal Officer & Corporate Secretary | -11,49k | 1,66M | Automatic Disposition | 144,16 - 145,89 | 54,90k | -17,31% |
| 2025-09-02 | Dr. Martina FlammerChief Medical Officer | -186,65k | 22,57M | Derivative Exercise and Sale | 17,07 - 146,05 | 14,63k | - |
| 2025-08-20 | Dr. Melvin SharokyIndependent Director | -10,00k | 1,30M | Vente | 129,50 | 301,61k | -3,21% |
| 2025-08-19 | Mr. Roger AdsettCOO | -25,00k | 3,19M | Vente | 127,42 - 128,27 | 41,89k | -37,37% |
| 2025-08-18 | Mr. William H. LewisPresident, CEO & Chairman | -6,87k | 806,98k | Derivative Exercise and Sale | 10,85 - 129,47 | 405,43k | - |
| 2025-08-14 | Ms. S. Nicole SchaefferChief People Strategy Officer | -10,00k | 1,27M | Vente | 126,57 - 128,16 | 27,26k | -26,84% |
| 2025-08-12 | Dr. Melvin SharokyIndependent Director | -10,00k | 1,22M | Vente | 121,58 | 311,61k | -3,11% |
| 2025-08-13 | Dr. Melvin SharokyIndependent Director | -21,10k | 0,00 | Other Disposition | - | 311,61k | -6,34% |
| 2025-08-04 | Mr. William H. LewisPresident, CEO & Chairman | -6,83k | 675,90k | Derivative Exercise and Sale | 10,85 - 110,91 | 405,43k | - |
| 2025-08-04 | Dr. Martina FlammerChief Medical Officer | -8,72k | 782,26k | Derivative Exercise and Sale | 19,74 - 109,50 | 14,63k | - |
| 2025-07-21 | Ms. Sara M. BonsteinCFO | -47,89k | 3,45M | Derivative Exercise and Sale | 26,46 - 103,03 | 1,52k | - |
| 2025-07-21 | Ms. Sara M. BonsteinCFO | -10,51k | 1,08M | Automatic Disposition | 103,03 | 1,52k | -87,36% |
| 2025-07-15 | Mr. William H. LewisPresident, CEO & Chairman | -6,83k | 625,11k | Derivative Exercise and Sale | 10,85 - 103,32 | 405,43k | - |
| 2025-07-11 | Mr. Michael Alexander SmithChief Legal Officer & Corporate Secretary | -748,00 | 72,11k | Vente | 96,41 | 66,39k | -1,11% |
| 2025-07-15 | Mr. Michael Alexander SmithChief Legal Officer & Corporate Secretary | -933,00 | 95,64k | Automatic Disposition | 102,51 | 66,39k | -1,39% |
| 2025-07-07 | Ms. Sara M. BonsteinCFO | -47,89k | 3,37M | Derivative Exercise and Sale | 19,74 - 96,19 | 12,14k | - |
| 2025-07-07 | Ms. Sara M. BonsteinCFO | -9,88k | 949,97k | Automatic Disposition | 96,19 | 12,14k | -44,85% |
| 2025-07-01 | Mr. William H. LewisPresident, CEO & Chairman | -6,83k | 597,51k | Derivative Exercise and Sale | 10,85 - 99,61 | 405,43k | - |
| 2025-06-23 | Ms. Sara M. BonsteinCFO | -47,89k | 3,95M | Derivative Exercise and Sale | 18,95 - 101,71 | 21,55k | - |
| 2025-06-23 | Ms. Sara M. BonsteinCFO | -9,88k | 1,01M | Automatic Disposition | 101,71 - 102,15 | 21,55k | -31,42% |
| 2025-06-16 | Mr. William H. LewisPresident, CEO & Chairman | -129,81k | 11,62M | Derivative Exercise and Sale | 10,85 - 101,23 | 405,08k | - |
| 2025-06-16 | Mr. William H. LewisPresident, CEO & Chairman | -5,20k | 522,06k | Automatic Disposition | 98,51 - 101,39 | 405,08k | -1,27% |
| 2025-06-16 | Mr. Roger AdsettCOO | -10,69k | 1,06M | Automatic Disposition | 98,50 - 99,32 | 62,37k | -14,63% |
| 2025-06-10 | Dr. Martina FlammerChief Medical Officer | -45,16k | 3,10M | Derivative Exercise and Sale | 17,07 - 94,50 | 14,63k | - |
| 2025-06-10 | Ms. S. Nicole SchaefferChief People Strategy Officer | -108,30k | 8,24M | Derivative Exercise and Sale | 13,91 - 95,49 | 36,91k | - |
| 2025-06-11 | Ms. S. Nicole SchaefferChief People Strategy Officer | -29,17k | 2,79M | Automatic Disposition | 95,49 - 96,02 | 36,91k | -44,15% |
| 2025-06-10 | Ms. Sara M. BonsteinCFO | -47,89k | 3,39M | Derivative Exercise and Sale | 17,07 - 89,85 | 31,43k | - |
| 2025-06-10 | Ms. Sara M. BonsteinCFO | -9,88k | 894,37k | Automatic Disposition | 89,85 - 91,66 | 31,43k | -23,91% |
| 2025-06-05 | Mr. Michael Alexander SmithChief Legal Officer & Corporate Secretary | -1,88k | 138,11k | Automatic Disposition | 73,50 | 67,72k | -2,70% |
| 2025-06-03 | Mr. Michael Alexander SmithChief Legal Officer & Corporate Secretary | -1,45k | 103,53k | Vente | 71,50 | 69,60k | -2,04% |
| 2025-06-03 | Dr. Martina FlammerChief Medical Officer | -1,69k | 120,55k | Vente | 71,50 | 14,63k | -10,34% |
| 2025-06-03 | Mr. Roger AdsettCOO | -1,86k | 132,99k | Vente | 71,50 | 73,06k | -2,48% |
| 2025-06-03 | Ms. Sara M. BonsteinCFO | -1,58k | 112,90k | Vente | 71,50 | 41,30k | -3,68% |
| 2025-06-03 | Mr. David W. J. McGirrInitié | -6,25k | 451,54k | Automatic Disposition | 71,30 - 73,27 | 92,67k | -6,32% |
| 2025-06-03 | Ms. S. Nicole SchaefferChief People Strategy Officer | -1,64k | 117,40k | Vente | 71,50 | 114,40k | -1,42% |
| 2025-06-02 | Mr. William H. LewisPresident, CEO & Chairman | -6,83k | 412,94k | Derivative Exercise and Sale | 10,85 - 71,94 | 410,28k | - |
| 2025-06-03 | Mr. William H. LewisPresident, CEO & Chairman | -5,47k | 391,25k | Vente | 71,50 | 410,28k | -1,32% |
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