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| Date | Nom du détenteur | Actions transigées | Fourchette de valeur ($) | Type d'opération | Fourchette de prix ($) | Actions en fin de déclaration | % de variation |
|---|---|---|---|---|---|---|---|
| 2026-06-01 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 3,82M | Derivative Exercise and Sale | 146,03 - 554,43 | 668,73k | - |
| 2026-05-26 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 4,06M | Derivative Exercise and Sale | 146,03 - 577,97 | 668,73k | - |
| 2026-06-01 | Mr. James C. EdgemondCFO & Treasurer | -10,00k | 4,30M | Derivative Exercise and Sale | 117,76 - 554,47 | 18,88k | - |
| 2026-05-29 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 3,87M | Derivative Exercise and Sale | 146,03 - 559,41 | 668,73k | - |
| 2026-05-28 | Mr. James C. EdgemondCFO & Treasurer | -10,00k | 4,48M | Derivative Exercise and Sale | 117,76 - 571,48 | 18,88k | - |
| 2026-05-28 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 3,99M | Derivative Exercise and Sale | 146,03 - 571,55 | 668,73k | - |
| 2026-05-27 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 4,08M | Derivative Exercise and Sale | 146,03 - 579,59 | 668,73k | - |
| 2026-05-26 | Mr. James C. EdgemondCFO & Treasurer | -10,00k | 4,55M | Derivative Exercise and Sale | 117,76 - 578,12 | 18,88k | - |
| 2026-05-26 | Dr. Martine A. RothblattFounder, Chairman & CEO | -11,07k | 0,00 | Other Disposition | - | 668,73k | -1,63% |
| 2026-05-22 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 4,01M | Derivative Exercise and Sale | 146,03 - 569,73 | 668,73k | - |
| 2026-05-21 | Mr. James C. EdgemondCFO & Treasurer | -10,00k | 4,46M | Derivative Exercise and Sale | 117,76 - 566,12 | 18,88k | - |
| 2026-05-21 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 3,97M | Derivative Exercise and Sale | 146,03 - 566,42 | 679,80k | - |
| 2026-05-20 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 3,99M | Derivative Exercise and Sale | 146,03 - 577,26 | 679,80k | - |
| 2026-05-21 | Mr. Paul A. MahonExec. VP, General Counsel & Corporate Secretary | -8,30k | 3,46M | Derivative Exercise and Sale | 146,03 - 566,05 | 45,17k | - |
| 2026-05-19 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 4,01M | Derivative Exercise and Sale | 146,03 - 572,36 | 679,80k | - |
| 2026-05-18 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 4,00M | Derivative Exercise and Sale | 146,03 - 569,99 | 679,80k | - |
| 2026-05-18 | Mr. James C. EdgemondCFO & Treasurer | -10,00k | 4,45M | Derivative Exercise and Sale | 117,76 - 570,18 | 18,88k | - |
| 2026-05-15 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 4,01M | Derivative Exercise and Sale | 146,03 - 572,25 | 679,80k | - |
| 2026-05-14 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 4,07M | Derivative Exercise and Sale | 146,03 - 578,29 | 679,80k | - |
| 2026-05-14 | Mr. James C. EdgemondCFO & Treasurer | -10,00k | 4,39M | Derivative Exercise and Sale | 135,42 - 578,59 | 18,88k | - |
| 2026-05-13 | Mr. Michael I. BenkowitzPresident & COO | -11,73k | 0,00 | Other Derivative Disposition | 217,50 | 0,00 | -100,00% |
| 2026-05-13 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 4,11M | Derivative Exercise and Sale | 146,03 - 583,81 | 679,80k | - |
| 2026-05-12 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 4,11M | Derivative Exercise and Sale | 146,03 - 583,44 | 679,80k | - |
| 2026-05-12 | Prof. Nilda MesaIndependent Director | -258,00 | 150,14k | Vente | 581,94 | 5,03k | -4,88% |
| 2026-05-11 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 4,06M | Derivative Exercise and Sale | 146,03 - 580,44 | 679,80k | - |
| 2026-05-11 | Mr. James C. EdgemondCFO & Treasurer | -10,00k | 4,38M | Derivative Exercise and Sale | 135,42 - 580,45 | 18,88k | - |
| 2026-05-07 | Dr. Martine A. RothblattFounder, Chairman & CEO | -19,00k | 8,09M | Derivative Exercise and Sale | 146,03 - 597,54 | 679,80k | - |
| 2026-05-07 | Mr. James C. EdgemondCFO & Treasurer | -10,00k | 4,43M | Derivative Exercise and Sale | 135,42 - 597,54 | 18,88k | - |
| 2026-05-06 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 4,21M | Derivative Exercise and Sale | 146,03 - 603,82 | 679,80k | - |
| 2026-05-07 | Mr. Paul A. MahonExec. VP, General Counsel & Corporate Secretary | -8,30k | 3,66M | Derivative Exercise and Sale | 146,03 - 597,54 | 45,17k | - |
| 2026-05-05 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 4,09M | Derivative Exercise and Sale | 146,03 - 581,68 | 679,80k | - |
| 2026-05-04 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 4,09M | Derivative Exercise and Sale | 146,03 - 582,30 | 679,80k | - |
| 2026-05-04 | Mr. James C. EdgemondCFO & Treasurer | -10,00k | 4,42M | Derivative Exercise and Sale | 135,42 - 582,29 | 18,88k | - |
| 2026-05-01 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 4,03M | Derivative Exercise and Sale | 146,03 - 571,95 | 679,80k | - |
| 2026-04-30 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 4,05M | Derivative Exercise and Sale | 146,03 - 579,51 | 679,80k | - |
| 2026-04-30 | Mr. James C. EdgemondCFO & Treasurer | -10,00k | 4,37M | Derivative Exercise and Sale | 135,42 - 578,76 | 18,88k | - |
| 2026-04-29 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 4,04M | Derivative Exercise and Sale | 146,03 - 573,89 | 679,80k | - |
| 2026-04-28 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 4,01M | Derivative Exercise and Sale | 146,03 - 571,79 | 679,80k | - |
| 2026-04-27 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 4,02M | Derivative Exercise and Sale | 146,03 - 572,22 | 679,80k | - |
| 2026-04-27 | Mr. James C. EdgemondCFO & Treasurer | -10,00k | 4,33M | Derivative Exercise and Sale | 135,42 - 571,92 | 18,88k | - |
| 2026-04-24 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 3,98M | Derivative Exercise and Sale | 146,03 - 567,41 | 679,80k | - |
| 2026-04-22 | Mr. James C. EdgemondCFO & Treasurer | -10,00k | 4,37M | Derivative Exercise and Sale | 135,42 - 576,62 | 18,88k | - |
| 2026-04-23 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 4,05M | Derivative Exercise and Sale | 146,03 - 576,33 | 679,80k | - |
| 2026-04-24 | Prof. Christopher PatuskyIndependent Vice Chair & Lead Independent Director | -2,91k | 1,36M | Derivative Exercise and Sale | 101,80 - 569,00 | 2,59k | - |
| 2026-04-21 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 4,03M | Derivative Exercise and Sale | 146,03 - 575,72 | 679,80k | - |
| 2026-04-20 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 4,10M | Derivative Exercise and Sale | 146,03 - 586,47 | 679,80k | - |
| 2026-04-20 | Mr. James C. EdgemondCFO & Treasurer | -10,00k | 4,42M | Derivative Exercise and Sale | 135,42 - 585,36 | 18,88k | - |
| 2026-04-17 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 4,19M | Derivative Exercise and Sale | 146,03 - 592,30 | 679,80k | - |
| 2026-04-17 | Prof. Christopher PatuskyIndependent Vice Chair & Lead Independent Director | -1 000,00 | 477,08k | Derivative Exercise and Sale | 101,80 - 578,88 | 2,59k | - |
| 2026-04-16 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 4,10M | Derivative Exercise and Sale | 146,03 - 581,33 | 679,80k | - |
| 2026-04-16 | Mr. James C. EdgemondCFO & Treasurer | -10,00k | 4,42M | Derivative Exercise and Sale | 135,42 - 581,64 | 18,88k | - |
| 2026-03-13 | Dr. Martine A. RothblattFounder, Chairman & CEO | -75,00 | 40,27k | Automatic Disposition | 536,95 | 679,80k | -0,01% |
| 2026-04-14 | Dr. Martine A. RothblattFounder, Chairman & CEO | -19,00k | 8,24M | Derivative Exercise and Sale | 146,03 - 584,24 | 679,80k | - |
| 2026-04-16 | Mr. Paul A. MahonExec. VP, General Counsel & Corporate Secretary | -8,30k | 3,58M | Derivative Exercise and Sale | 146,03 - 578,21 | 45,17k | - |
| 2026-04-13 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 4,07M | Derivative Exercise and Sale | 146,03 - 579,53 | 679,87k | - |
| 2026-04-13 | Mr. James C. EdgemondCFO & Treasurer | -10,00k | 4,39M | Derivative Exercise and Sale | 135,42 - 580,03 | 18,88k | - |
| 2026-04-10 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 4,02M | Derivative Exercise and Sale | 146,03 - 573,01 | 679,87k | - |
| 2026-04-09 | Mr. James C. EdgemondCFO & Treasurer | -10,00k | 4,42M | Derivative Exercise and Sale | 135,42 - 582,30 | 18,88k | - |
| 2026-04-09 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 4,10M | Derivative Exercise and Sale | 146,03 - 581,45 | 679,87k | - |
| 2026-04-08 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 4,13M | Derivative Exercise and Sale | 146,03 - 585,48 | 679,87k | - |
| 2026-04-07 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 3,97M | Derivative Exercise and Sale | 146,03 - 569,62 | 679,87k | - |
| 2026-04-06 | Mr. James C. EdgemondCFO & Treasurer | -10,00k | 4,23M | Derivative Exercise and Sale | 135,42 - 566,01 | 18,88k | - |
| 2026-04-06 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 3,92M | Derivative Exercise and Sale | 146,03 - 566,00 | 679,87k | - |
| 2026-04-02 | Mr. James C. EdgemondCFO & Treasurer | -10,00k | 4,26M | Derivative Exercise and Sale | 135,42 - 571,65 | 18,88k | - |
| 2026-04-02 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 3,95M | Derivative Exercise and Sale | 146,03 - 571,66 | 679,87k | - |
| 2026-04-02 | Mr. Paul A. MahonExec. VP, General Counsel & Corporate Secretary | -8,30k | 3,48M | Derivative Exercise and Sale | 146,03 - 571,61 | 45,17k | - |
| 2026-03-31 | Dr. Martine A. RothblattFounder, Chairman & CEO | -19,00k | 8,32M | Derivative Exercise and Sale | 146,03 - 596,11 | 679,87k | - |
| 2026-04-01 | Dr. Martine A. RothblattFounder, Chairman & CEO | -349,19k | 0,00 | Other Derivative Disposition | 135,42 | 349,19k | -50,00% |
| 2026-04-01 | Dr. Martine A. RothblattFounder, Chairman & CEO | -500,00k | 0,00 | Other Derivative Disposition | 117,76 | 0,00 | -100,00% |
| 2026-03-27 | Dr. Martine A. RothblattFounder, Chairman & CEO | -19,00k | 7,84M | Derivative Exercise and Sale | 146,03 - 602,72 | 679,87k | - |
| 2026-03-30 | Mr. Christopher CauseyIndependent Director | -1,30k | 630,34k | Derivative Exercise and Sale | 119,76 - 604,64 | 4,19k | - |
| 2026-03-30 | Mr. James C. EdgemondCFO & Treasurer | -10,00k | 4,58M | Derivative Exercise and Sale | 135,42 - 606,53 | 18,88k | - |
| 2026-03-26 | Mr. James C. EdgemondCFO & Treasurer | -10,00k | 4,00M | Derivative Exercise and Sale | 135,42 - 540,04 | 18,88k | - |
| 2026-03-26 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 3,70M | Derivative Exercise and Sale | 146,03 - 539,98 | 679,87k | - |
| 2026-03-25 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 3,78M | Derivative Exercise and Sale | 146,03 - 548,52 | 679,87k | - |
| 2026-03-26 | Governor Thomas G. ThompsonIndependent Director | -2,00k | 874,73k | Derivative Exercise and Sale | 101,80 - 540,18 | 21,60k | - |
| 2026-03-24 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 3,64M | Derivative Exercise and Sale | 146,03 - 536,02 | 679,87k | - |
| 2026-03-23 | Mr. James C. EdgemondCFO & Treasurer | -10,00k | 3,92M | Derivative Exercise and Sale | 135,42 - 536,28 | 18,88k | - |
| 2026-03-23 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 3,62M | Derivative Exercise and Sale | 146,03 - 536,16 | 679,87k | - |
| 2026-03-23 | Dr. Judy D. OlianIndependent Director | -200,00 | 106,00k | Automatic Disposition | 530,00 | 4,25k | -4,50% |
| 2026-03-20 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 3,60M | Derivative Exercise and Sale | 146,03 - 529,08 | 679,87k | - |
| 2026-03-19 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 3,64M | Derivative Exercise and Sale | 146,03 - 532,90 | 679,87k | - |
| 2026-03-18 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 3,64M | Derivative Exercise and Sale | 146,03 - 539,99 | 679,87k | - |
| 2026-03-19 | Mr. Paul A. MahonExec. VP, General Counsel & Corporate Secretary | -8,30k | 3,19M | Derivative Exercise and Sale | 146,03 - 533,41 | 45,17k | - |
| 2026-03-17 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 3,71M | Derivative Exercise and Sale | 146,03 - 540,92 | 679,87k | - |
| 2026-03-16 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 3,68M | Derivative Exercise and Sale | 146,03 - 537,37 | 679,87k | - |
| 2026-03-15 | Mr. Michael I. BenkowitzPresident & COO | 18,68k | 0,00 | Derivative Exercise and Retained Stock | - | 21,76k | 606,36% |
| 2026-03-15 | Mr. Michael I. BenkowitzPresident & COO | -14,71k | 7,88M | Derivative Exercise and Sale | 536,12 | 21,76k | - |
| 2026-03-15 | Mr. Paul A. MahonExec. VP, General Counsel & Corporate Secretary | 8,33k | 0,00 | Derivative Exercise and Retained Stock | - | 45,17k | 22,60% |
| 2026-03-15 | Mr. Paul A. MahonExec. VP, General Counsel & Corporate Secretary | -8,36k | 4,48M | Derivative Exercise and Sale | 536,12 | 45,17k | - |
| 2026-03-15 | Mr. James C. EdgemondCFO & Treasurer | 10,69k | 0,00 | Derivative Exercise and Retained Stock | - | 18,88k | 130,65% |
| 2026-03-15 | Mr. James C. EdgemondCFO & Treasurer | -8,79k | 4,71M | Derivative Exercise and Sale | 536,12 | 18,88k | - |
| 2026-03-15 | Dr. Martine A. RothblattFounder, Chairman & CEO | 69,58k | 0,00 | Derivative Exercise and Retained Stock | - | 679,87k | 11,40% |
| 2026-03-15 | Dr. Martine A. RothblattFounder, Chairman & CEO | -29,20k | 15,65M | Sale to Issuer | 536,12 | 679,87k | -4,12% |
| 2026-03-17 | Ms. Jan K. MalcolmIndependent Director | -45,00 | 24,01k | Automatic Disposition | 533,51 | 125,00 | -26,47% |
| 2026-03-16 | Dr. Judy D. OlianIndependent Director | -200,00 | 107,09k | Automatic Disposition | 535,44 | 4,45k | -4,31% |
| 2026-03-12 | Dr. Martine A. RothblattFounder, Chairman & CEO | -19,00k | 7,45M | Derivative Exercise and Sale | 146,03 - 544,58 | 647,77k | - |
| 2026-03-10 | Dr. Martine A. RothblattFounder, Chairman & CEO | -19,00k | 7,48M | Derivative Exercise and Sale | 146,03 - 548,10 | 639,49k | - |
| 2026-03-06 | Dr. Martine A. RothblattFounder, Chairman & CEO | -19,00k | 6,68M | Derivative Exercise and Sale | 146,03 - 529,83 | 639,49k | - |
| 2026-03-06 | Dr. Judy D. OlianIndependent Director | -200,00 | 102,00k | Automatic Disposition | 510,00 | 4,65k | -4,13% |
| 2026-03-05 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 3,22M | Derivative Exercise and Sale | 146,03 - 487,98 | 639,49k | - |
| 2026-03-03 | Dr. Martine A. RothblattFounder, Chairman & CEO | -19,00k | 6,62M | Derivative Exercise and Sale | 146,03 - 507,09 | 639,49k | - |
| 2026-03-05 | Mr. Paul A. MahonExec. VP, General Counsel & Corporate Secretary | -8,30k | 2,80M | Derivative Exercise and Sale | 146,03 - 487,65 | 36,84k | - |
| 2026-03-04 | Dr. Raymond C. KurzweilIndependent Director | -4,91k | 1,90M | Derivative Exercise and Sale | 101,80 - 489,02 | 12,67k | - |
| 2026-03-04 | Governor Thomas G. ThompsonIndependent Director | -2,00k | 775,24k | Derivative Exercise and Sale | 101,80 - 489,42 | 21,60k | - |
| 2026-03-04 | Mr. Christopher CauseyIndependent Director | -20,00 | 7,41k | Derivative Exercise and Sale | 119,76 - 490,17 | 4,19k | - |
| 2026-03-03 | Ms. Jan K. MalcolmIndependent Director | -50,00 | 25,46k | Automatic Disposition | 509,20 | 170,00 | -22,73% |
| 2026-03-02 | Dr. Martine A. RothblattFounder, Chairman & CEO | -9,50k | 3,51M | Derivative Exercise and Sale | 146,03 - 525,28 | 639,49k | - |
| 2026-02-27 | Dr. Judy D. OlianIndependent Director | -200,00 | 101,91k | Automatic Disposition | 509,55 | 4,85k | -3,96% |
| 2026-02-25 | Mr. Christopher CauseyIndependent Director | -1 000,00 | 400,24k | Derivative Exercise and Sale | 119,76 - 520,00 | 4,19k | - |
| 2026-02-23 | Mr. Michael I. BenkowitzPresident & COO | -14,44k | 4,97M | Derivative Exercise and Sale | 117,76 - 472,13 | 2,65k | - |
| 2026-02-19 | Mr. Paul A. MahonExec. VP, General Counsel & Corporate Secretary | -8,30k | 2,74M | Derivative Exercise and Sale | 146,03 - 478,92 | 36,78k | - |
| 2026-02-17 | Mr. Michael I. BenkowitzPresident & COO | -22,50k | 7,94M | Derivative Exercise and Sale | 117,76 - 480,75 | 2,65k | - |
| 2026-02-17 | Ms. Jan K. MalcolmIndependent Director | -50,00 | 23,73k | Automatic Disposition | 474,68 | 220,00 | -18,52% |
| 2026-02-09 | Mr. Michael I. BenkowitzPresident & COO | -22,50k | 7,81M | Derivative Exercise and Sale | 117,76 - 474,65 | 2,65k | - |
| 2026-02-05 | Mr. Paul A. MahonExec. VP, General Counsel & Corporate Secretary | -8,30k | 2,80M | Derivative Exercise and Sale | 146,03 - 485,52 | 36,78k | - |
| 2026-02-03 | Ms. Jan K. MalcolmIndependent Director | -50,00 | 23,71k | Automatic Disposition | 474,23 | 270,00 | -15,63% |
| 2026-02-02 | Mr. Michael I. BenkowitzPresident & COO | -22,50k | 7,72M | Derivative Exercise and Sale | 117,76 - 470,95 | 2,65k | - |
| 2026-01-20 | Mr. Michael I. BenkowitzPresident & COO | -30,38k | 10,25M | Derivative Exercise and Sale | 117,76 - 471,91 | 2,65k | - |
| 2026-01-20 | Mr. Michael I. BenkowitzPresident & COO | -14,63k | 6,80M | Automatic Disposition | 456,87 - 470,76 | 2,65k | -84,67% |
| 2026-01-20 | Mr. Michael I. BenkowitzPresident & COO | -14,63k | 1,72M | Other Disposition | 117,76 | 2,65k | -84,67% |
| 2026-01-16 | Ms. Jan K. MalcolmIndependent Director | -50,00 | 23,05k | Automatic Disposition | 460,98 | 320,00 | -13,51% |
| 2026-01-15 | Mr. Paul A. MahonExec. VP, General Counsel & Corporate Secretary | -8,30k | 2,69M | Derivative Exercise and Sale | 146,03 - 474,74 | 36,78k | - |
| 2026-01-12 | Mr. Michael I. BenkowitzPresident & COO | -22,50k | 7,92M | Derivative Exercise and Sale | 117,76 - 479,51 | 2,65k | - |
| 2026-01-05 | Mr. Michael I. BenkowitzPresident & COO | -22,50k | 8,09M | Derivative Exercise and Sale | 117,76 - 494,27 | 2,65k | - |
| 2026-01-06 | Mr. Christopher CauseyIndependent Director | -1 000,00 | 390,24k | Derivative Exercise and Sale | 119,76 - 510,00 | 4,19k | - |
| 2026-01-05 | Ms. Jan K. MalcolmIndependent Director | -50,00 | 24,75k | Automatic Disposition | 495,01 | 370,00 | -11,90% |
| 2026-01-02 | Mr. Christopher CauseyIndependent Director | -1 000,00 | 380,25k | Derivative Exercise and Sale | 119,76 - 500,01 | 4,19k | - |
| 2026-01-02 | Mr. Paul A. MahonExec. VP, General Counsel & Corporate Secretary | -8,30k | 2,82M | Derivative Exercise and Sale | 146,03 - 489,15 | 36,78k | - |
| 2025-12-29 | Mr. Michael I. BenkowitzPresident & COO | -7,88k | 2,81M | Derivative Exercise and Sale | 146,03 - 502,79 | 2,65k | - |
| 2025-12-29 | Mr. Michael I. BenkowitzPresident & COO | -14,63k | 7,35M | Automatic Disposition | 502,79 | 2,65k | -84,67% |
| 2025-12-29 | Mr. Michael I. BenkowitzPresident & COO | -14,63k | 1,72M | Other Disposition | 117,76 | 2,65k | -84,67% |
| 2025-12-22 | Mr. Michael I. BenkowitzPresident & COO | -22,50k | 8,70M | Derivative Exercise and Sale | 117,76 - 518,99 | 2,65k | - |
| 2025-12-24 | Mr. Paul A. MahonExec. VP, General Counsel & Corporate Secretary | -11,00k | 4,04M | Derivative Exercise and Sale | 146,03 - 516,06 | 36,78k | - |
| 2025-12-23 | Ms. Jan K. MalcolmIndependent Director | -50,00 | 25,61k | Automatic Disposition | 512,12 | 420,00 | -10,64% |
| 2025-12-22 | Dr. Louis W. SullivanIndependent Director & Member of the Scientific Advisory Board | -5,95k | 1,83M | Derivative Exercise and Sale | 183,98 - 512,34 | 3,79k | - |
| 2025-12-18 | Governor Thomas G. ThompsonIndependent Director | -910,00 | 362,90k | Derivative Exercise and Sale | 101,80 - 500,59 | 21,60k | - |
| 2025-12-17 | Dr. Martine A. RothblattFounder, Chairman & CEO | -10,00k | 3,85M | Derivative Exercise and Sale | 120,26 - 510,86 | 639,49k | - |
| 2025-12-15 | Mr. James C. EdgemondCFO & Treasurer | -3,52k | 1,23M | Derivative Exercise and Sale | 146,03 - 500,30 | 8,14k | - |
| 2025-12-15 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,99M | Derivative Exercise and Sale | 120,26 - 497,17 | 639,49k | - |
| 2025-12-15 | Mr. Michael I. BenkowitzPresident & COO | -22,50k | 5,68M | Derivative Exercise and Sale | 117,76 - 500,31 | 2,65k | - |
| 2025-12-15 | Prof. Christopher PatuskyIndependent Vice Chair & Lead Independent Director | -1 000,00 | 394,15k | Derivative Exercise and Sale | 101,80 - 495,95 | 2,59k | - |
| 2025-12-11 | Ms. Jan K. MalcolmIndependent Director | -50,00 | 24,15k | Automatic Disposition | 482,98 | 470,00 | -9,62% |
| 2025-12-11 | Mr. Paul A. MahonExec. VP, General Counsel & Corporate Secretary | -11,00k | 3,72M | Derivative Exercise and Sale | 146,03 - 487,37 | 36,78k | - |
| 2025-12-11 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,94M | Derivative Exercise and Sale | 120,26 - 490,98 | 639,49k | - |
| 2025-12-09 | Prof. Nilda MesaIndependent Director | -187,00 | 90,06k | Vente | 481,63 | 5,29k | -3,42% |
| 2025-12-09 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,87M | Derivative Exercise and Sale | 120,26 - 481,72 | 639,49k | - |
| 2025-12-08 | Dr. Martine A. RothblattFounder, Chairman & CEO | -5,00k | 0,00 | Other Disposition | - | 639,49k | -0,78% |
| 2025-12-08 | Mr. James C. EdgemondCFO & Treasurer | -21,00k | 6,98M | Derivative Exercise and Sale | 146,03 - 486,71 | 8,14k | - |
| 2025-12-08 | Mr. Michael I. BenkowitzPresident & COO | -22,50k | 5,28M | Derivative Exercise and Sale | 117,76 - 478,58 | 2,65k | - |
| 2025-12-05 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,91M | Derivative Exercise and Sale | 120,26 - 488,97 | 644,49k | - |
| 2025-12-03 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,86M | Derivative Exercise and Sale | 120,26 - 480,60 | 644,49k | - |
| 2025-12-01 | Mr. James C. EdgemondCFO & Treasurer | -21,00k | 7,01M | Derivative Exercise and Sale | 146,03 - 484,68 | 8,14k | - |
| 2025-12-01 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,89M | Derivative Exercise and Sale | 120,26 - 484,68 | 644,49k | - |
| 2025-12-01 | Mr. Michael I. BenkowitzPresident & COO | -22,50k | 7,93M | Derivative Exercise and Sale | 117,76 - 483,42 | 2,65k | - |
| 2025-11-26 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,93M | Derivative Exercise and Sale | 120,26 - 490,25 | 644,49k | - |
| 2025-11-24 | Mr. Michael I. BenkowitzPresident & COO | -22,50k | 7,57M | Derivative Exercise and Sale | 117,76 - 473,66 | 2,65k | - |
| 2025-11-24 | Mr. James C. EdgemondCFO & Treasurer | -21,00k | 6,88M | Derivative Exercise and Sale | 146,03 - 482,29 | 8,14k | - |
| 2025-11-26 | Mr. Paul A. MahonExec. VP, General Counsel & Corporate Secretary | -11,00k | 3,86M | Derivative Exercise and Sale | 135,42 - 488,13 | 36,78k | - |
| 2025-11-24 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,82M | Derivative Exercise and Sale | 120,26 - 481,23 | 644,49k | - |
| 2025-11-20 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,85M | Derivative Exercise and Sale | 120,26 - 480,44 | 644,49k | - |
| 2025-11-18 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,83M | Derivative Exercise and Sale | 120,26 - 475,10 | 644,49k | - |
| 2025-11-17 | Mr. Michael I. BenkowitzPresident & COO | -22,50k | 7,45M | Derivative Exercise and Sale | 135,42 - 470,43 | 2,65k | - |
| 2025-11-17 | Mr. James C. EdgemondCFO & Treasurer | -21,00k | 6,81M | Derivative Exercise and Sale | 146,03 - 476,47 | 8,12k | - |
| 2025-11-14 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,76M | Derivative Exercise and Sale | 120,26 - 468,32 | 644,49k | - |
| 2025-11-12 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 3,79M | Derivative Exercise and Sale | 120,26 - 1,29k | 644,49k | - |
| 2025-11-13 | Mr. Paul A. MahonExec. VP, General Counsel & Corporate Secretary | -11,00k | 3,62M | Derivative Exercise and Sale | 135,42 - 469,09 | 36,78k | - |
| 2025-11-10 | Mr. James C. EdgemondCFO & Treasurer | -21,00k | 6,43M | Derivative Exercise and Sale | 146,03 - 455,83 | 8,12k | - |
| 2025-11-10 | Mr. Michael I. BenkowitzPresident & COO | -22,50k | 7,04M | Derivative Exercise and Sale | 135,42 - 452,09 | 2,65k | - |
| 2025-11-10 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,64M | Derivative Exercise and Sale | 120,26 - 452,78 | 644,49k | - |
| 2025-11-06 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,63M | Derivative Exercise and Sale | 120,26 - 452,21 | 644,49k | - |
| 2025-11-04 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,53M | Derivative Exercise and Sale | 120,26 - 442,26 | 644,49k | - |
| 2025-11-04 | Mr. James C. EdgemondCFO & Treasurer | -21,00k | 6,09M | Derivative Exercise and Sale | 146,03 - 439,51 | 8,12k | - |
| 2025-11-03 | Mr. Michael I. BenkowitzPresident & COO | -22,50k | 6,53M | Derivative Exercise and Sale | 135,42 - 441,94 | 2,65k | - |
| 2025-10-31 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,59M | Derivative Exercise and Sale | 120,26 - 451,49 | 644,49k | - |
| 2025-11-03 | Mr. Christopher CauseyIndependent Director | -450,00 | 0,00 | Other Disposition | - | 4,19k | -9,70% |
| 2025-10-29 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,58M | Derivative Exercise and Sale | 120,26 - 451,29 | 644,49k | - |
| 2025-10-30 | Mr. Paul A. MahonExec. VP, General Counsel & Corporate Secretary | -11,00k | 3,46M | Derivative Exercise and Sale | 135,42 - 454,15 | 36,78k | - |
| 2025-10-27 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,36M | Derivative Exercise and Sale | 120,26 - 420,29 | 643,49k | - |
| 2025-10-27 | Mr. Michael I. BenkowitzPresident & COO | -22,50k | 6,26M | Derivative Exercise and Sale | 135,42 - 417,50 | 2,78k | - |
| 2024-09-09 | Mr. Christopher CauseyIndependent Director | -225,00 | 0,00 | Other Disposition | - | 4,64k | -4,62% |
| 2025-10-23 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,42M | Derivative Exercise and Sale | 120,26 - 426,40 | 644,49k | - |
| 2025-10-21 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,44M | Derivative Exercise and Sale | 120,26 - 432,20 | 644,49k | - |
| 2025-10-20 | Mr. Michael I. BenkowitzPresident & COO | -22,50k | 6,49M | Derivative Exercise and Sale | 135,42 - 427,41 | 2,65k | - |
| 2025-10-17 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,46M | Derivative Exercise and Sale | 120,26 - 434,22 | 644,49k | - |
| 2025-10-16 | Mr. Paul A. MahonExec. VP, General Counsel & Corporate Secretary | -11,00k | 3,26M | Derivative Exercise and Sale | 135,42 - 435,42 | 36,78k | - |
| 2025-10-13 | Mr. Michael I. BenkowitzPresident & COO | -22,50k | 6,78M | Derivative Exercise and Sale | 135,42 - 440,35 | 2,65k | - |
| 2025-10-13 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,55M | Derivative Exercise and Sale | 120,26 - 441,40 | 644,49k | - |
| 2025-10-09 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,61M | Derivative Exercise and Sale | 120,26 - 451,24 | 644,49k | - |
| 2025-10-07 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,65M | Derivative Exercise and Sale | 120,26 - 456,52 | 644,49k | - |
| 2025-10-06 | Mr. Michael I. BenkowitzPresident & COO | -22,50k | 7,00M | Derivative Exercise and Sale | 135,42 - 454,81 | 2,65k | - |
| 2025-10-03 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,62M | Derivative Exercise and Sale | 120,26 - 451,18 | 666,42k | - |
| 2025-10-01 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,48M | Derivative Exercise and Sale | 120,26 - 436,70 | 644,49k | - |
| 2025-10-02 | Mr. Paul A. MahonExec. VP, General Counsel & Corporate Secretary | -11,00k | 3,31M | Derivative Exercise and Sale | 135,42 - 440,16 | 36,78k | - |
| 2025-09-29 | Mr. Michael I. BenkowitzPresident & COO | -22,50k | 6,36M | Derivative Exercise and Sale | 135,42 - 430,75 | 2,65k | - |
| 2025-09-29 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,43M | Derivative Exercise and Sale | 120,26 - 430,81 | 644,49k | - |
| 2025-09-25 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,47M | Derivative Exercise and Sale | 120,26 - 431,90 | 644,49k | - |
| 2025-09-24 | Mr. Christopher CauseyIndependent Director | -1 000,00 | 320,24k | Derivative Exercise and Sale | 119,76 - 440,00 | 4,87k | - |
| 2025-09-23 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,45M | Derivative Exercise and Sale | 120,26 - 435,84 | 644,49k | - |
| 2025-09-22 | Mr. Michael I. BenkowitzPresident & COO | -22,50k | 6,24M | Derivative Exercise and Sale | 135,42 - 416,35 | 2,65k | - |
| 2025-09-19 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,35M | Derivative Exercise and Sale | 120,26 - 417,89 | 644,49k | - |
| 2025-09-19 | Dr. Judy D. OlianIndependent Director | -1,80k | 747,77k | Vente | 415,43 | 5,05k | -26,30% |
| 2025-09-18 | Mr. Paul A. MahonExec. VP, General Counsel & Corporate Secretary | -11,00k | 2,98M | Derivative Exercise and Sale | 135,42 - 408,11 | 36,78k | - |
| 2025-09-17 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,26M | Derivative Exercise and Sale | 120,26 - 406,04 | 644,49k | - |
| 2025-09-16 | Dr. Martine A. RothblattFounder, Chairman & CEO | -4,00k | 1,12M | Derivative Exercise and Sale | 120,26 - 400,59 | 644,49k | - |
| 2025-09-15 | Mr. Michael I. BenkowitzPresident & COO | -22,50k | 5,88M | Derivative Exercise and Sale | 135,42 - 403,08 | 2,65k | - |
| 2025-09-12 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,25M | Derivative Exercise and Sale | 120,26 - 404,89 | 644,49k | - |
| 2025-09-10 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,22M | Derivative Exercise and Sale | 120,26 - 399,33 | 644,49k | - |
| 2025-09-08 | Mr. Michael I. BenkowitzPresident & COO | -16,38k | 1,27M | Derivative Exercise and Sale | 135,42 - 400,08 | 2,65k | - |
| 2025-09-09 | Ms. Jan K. MalcolmIndependent Director | -700,00 | 280,20k | Vente | 400,29 | 520,00 | -57,38% |
| 2025-09-10 | Governor Thomas G. ThompsonIndependent Director | -4,56k | 791,39k | Derivative Exercise and Sale | 229,81 - 403,36 | 21,60k | - |
| 2025-09-09 | Dr. Martine A. RothblattFounder, Chairman & CEO | -8,00k | 2,23M | Derivative Exercise and Sale | 120,26 - 399,43 | 644,49k | - |
| 2025-09-04 | Mr. Paul A. MahonExec. VP, General Counsel & Corporate Secretary | -11,00k | 2,75M | Derivative Exercise and Sale | 135,42 - 396,54 | 36,78k | - |
| 2025-09-01 | Mr. Michael I. BenkowitzPresident & COO | -22,50k | 6,27M | Derivative Exercise and Sale | 135,42 - 419,63 | 2,65k | - |
| 2025-09-02 | Mr. Christopher CauseyIndependent Director | -3,00k | 872,73k | Derivative Exercise and Sale | 132,30 - 430,00 | 4,87k | - |
| 2025-08-21 | Mr. Paul A. MahonExec. VP, General Counsel & Corporate Secretary | -11,00k | 1,91M | Derivative Exercise and Sale | 135,42 - 310,25 | 36,78k | - |
| 2025-08-07 | Mr. Paul A. MahonExec. VP, General Counsel & Corporate Secretary | -11,00k | 1,81M | Derivative Exercise and Sale | 135,42 - 303,45 | 36,78k | - |
| 2025-07-25 | Dr. Judy D. OlianIndependent Director | 1,19k | 0,00 | Derivative Exercise and Retained Stock | - | 6,85k | 21,04% |
| 2025-07-25 | Prof. Christopher PatuskyIndependent Vice Chair & Lead Independent Director | 590,00 | 0,00 | Derivative Exercise and Retained Stock | - | 2,59k | 29,50% |
| 2025-07-25 | Prof. Nilda MesaIndependent Director | 590,00 | 0,00 | Derivative Exercise and Retained Stock | - | 5,47k | 12,08% |
| 2025-07-25 | Dr. Raymond C. KurzweilIndependent Director | 590,00 | 0,00 | Derivative Exercise and Retained Stock | - | 12,67k | 4,88% |
| 2025-07-25 | Mr. Richard GiltnerIndependent Director | 1,19k | 0,00 | Derivative Exercise and Retained Stock | - | 20,57k | 6,14% |
| 2025-07-25 | Dr. Louis W. SullivanIndependent Director & Member of the Scientific Advisory Board | 590,00 | 0,00 | Derivative Exercise and Retained Stock | - | 3,79k | 18,44% |
| 2025-07-25 | Mr. Christopher CauseyIndependent Director | 1,19k | 0,00 | Derivative Exercise and Retained Stock | - | 4,87k | 32,38% |
| 2025-06-26 | Ms. Jan K. MalcolmIndependent Director | 1,22k | 0,00 | Derivative Exercise and Retained Stock | - | 1,22k | - |
| 2025-07-24 | Mr. Paul A. MahonExec. VP, General Counsel & Corporate Secretary | -11,00k | 1,86M | Derivative Exercise and Sale | 135,42 - 305,14 | 36,78k | - |
| 2025-07-10 | Mr. Paul A. MahonExec. VP, General Counsel & Corporate Secretary | -11,00k | 1,81M | Derivative Exercise and Sale | 135,42 - 301,20 | 36,78k | - |
| 2025-06-26 | Mr. Paul A. MahonExec. VP, General Counsel & Corporate Secretary | -11,00k | 1,65M | Derivative Exercise and Sale | 135,42 - 288,80 | 36,78k | - |
| 2025-06-24 | Prof. Nilda MesaIndependent Director | -645,00 | 187,05k | Vente | 289,99 | 4,88k | -11,67% |
| 2025-06-24 | Mr. Richard GiltnerIndependent Director | 1,96k | 344,54k | Derivative Exercise and Retained Stock | 175,43 | 19,38k | 11,27% |
| 2025-06-24 | Mr. Richard GiltnerIndependent Director | -3,04k | 346,61k | Derivative Exercise and Sale | 175,43 - 289,60 | 19,38k | - |
| 2025-06-12 | Mr. Paul A. MahonExec. VP, General Counsel & Corporate Secretary | -11,00k | 1,59M | Derivative Exercise and Sale | 135,42 - 282,27 | 36,78k | - |
| 2025-06-09 | Mr. James C. EdgemondCFO & Treasurer | -12,00k | 2,49M | Derivative Exercise and Sale | 117,76 - 328,28 | 8,12k | - |
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