DOW JONES NEWSWIRES 
 

Abbott Laboratories (ABT) posted a 53% jump in first-quarter net income, boosted by a gain from the sale of a joint venture and continuing strong sales of its new Xience stent and Humira arthritis drug.

But shares fell 4.3% in premarket trading Wednesday to $42.78 as revenue was short of analysts' expectations and the company reiterated its second-quarter and full-year earnings targets. The stock through Tuesday was down nearly one-quarter the past two months.

The results of the maker of drugs and medical devices have held up well against their rivals, while the company has been able to navigate through the recession thanks to its broader product base than many drug companies and relatively little exposure to patent expirations, the bane of Big Pharma.

Abbott's Xience drug-coated stent - used to prop open damaged arteries - has vaulted to a leading position in the stent market since hitting the U.S. last summer, helping Abbott's medical-products sales. That segment saw 8.8% growth amid a more than 40% surge in stent sales.

Abbott reported first-quarter net income of $1.44 billion, or 92 cents a share, up from $938 million, or 60 cents a share, a year earlier. Excluding items such as a gain from the end of its Tap Pharmaceuticals joint venture, the company's earnings from continuing operations rose to 73 cents a share from 63 cents. In January, the company projected 69 cents to 71 cents, below analysts' estimates at the time.

Net sales slipped 0.7% to $6.72 billion due to the stronger dollar and the loss of patent protection for the anti-epilepsy drug Depakote. On average, analysts were most recently expecting sales of $7.06 billion.

Gross margin edged up to 56.3% from 56.2%.

Pharmaceutical sales - Abbott's biggest business - fell 5.7%. Its Humira treatment for various forms of arthritis, gastrointestinal disorder and other disorders had a 17% worldwide sales jump. Depakote reported a 68% plunge in U.S. sales to $110 million.

-By Mike Barris, Dow Jones Newswires; 201-938-5658; mike.barris@dowjones.com