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| Date | Nom du détenteur | Actions transigées | Fourchette de valeur ($) | Type d'opération | Fourchette de prix ($) | Actions en fin de déclaration | % de variation |
|---|---|---|---|---|---|---|---|
| 2026-05-29 | Dr. Laurent FischerIndependent Director | 3,98k | 0,00 | Derivative Exercise and Retained Stock | - | 10,73k | 58,92% |
| 2026-05-29 | Dr. Lon CardonIndependent Director | 3,98k | 0,00 | Derivative Exercise and Retained Stock | - | 9,68k | 69,74% |
| 2026-05-29 | Ms. Sona Saira Gonsalves RamasastryIndependent Director | -3,98k | 397,70k | Derivative Exercise and Sale | 100,00 | - | - |
| 2026-05-29 | Mr. Timothy P. WalbertIndependent Director | 3,98k | 0,00 | Derivative Exercise and Retained Stock | - | 9,68k | 69,74% |
| 2026-05-15 | Ms. Sona Saira Gonsalves RamasastryIndependent Director | -2,00k | 171,92k | Derivative Exercise and Sale | 23,51 - 109,47 | 0,00 | - |
| 2026-04-15 | Ms. Sona Saira Gonsalves RamasastryIndependent Director | -2,00k | 146,78k | Derivative Exercise and Sale | 23,51 - 96,90 | 0,00 | - |
| 2026-03-15 | Mr. Eric H. BjerkholtCFO | 6,05k | 0,00 | Derivative Exercise and Retained Stock | - | 49,79k | 13,82% |
| 2026-03-15 | Mr. Eric H. BjerkholtCFO | -7,29k | 670,24k | Derivative Exercise and Sale | 91,98 | 49,79k | - |
| 2026-03-16 | Ms. Sona Saira Gonsalves RamasastryIndependent Director | -2,00k | 134,50k | Derivative Exercise and Sale | 23,51 - 90,76 | - | - |
| 2026-03-15 | Mr. Peter RadovichCOO & President | 13,71k | 0,00 | Derivative Exercise and Retained Stock | - | 40,27k | 51,59% |
| 2026-03-15 | Mr. Peter RadovichCOO & President | -16,52k | 1,52M | Derivative Exercise and Sale | 91,98 | 40,27k | - |
| 2026-03-15 | Ms. Jolanda HoweSenior VP & Global Controller | 3,93k | 0,00 | Derivative Exercise and Retained Stock | - | 8,43k | 87,19% |
| 2026-03-15 | Ms. Jolanda HoweSenior VP & Global Controller | -4,73k | 435,24k | Derivative Exercise and Sale | 91,98 | 8,43k | - |
| 2026-03-15 | Dr. Joanne M. J. QuanChief Medical Officer | 6,05k | 0,00 | Derivative Exercise and Retained Stock | - | 18,86k | 47,18% |
| 2026-03-15 | Dr. Joanne M. J. QuanChief Medical Officer | -7,29k | 670,24k | Derivative Exercise and Sale | 91,98 | 18,86k | - |
| 2026-03-15 | Mr. Christopher PeetzCEO & Director | 34,02k | 0,00 | Derivative Exercise and Retained Stock | - | 381,81k | 9,78% |
| 2026-03-15 | Mr. Christopher PeetzCEO & Director | -40,99k | 3,77M | Derivative Exercise and Sale | 91,98 | 381,81k | - |
| 2026-03-06 | Mr. Peter RadovichCOO & President | 5,91k | 93,82k | Derivative Exercise and Retained Stock | 15,87 | 26,57k | 28,62% |
| 2026-02-13 | Ms. Sona Saira Gonsalves RamasastryIndependent Director | -2,00k | 157,16k | Derivative Exercise and Sale | 23,51 - 102,09 | 0,00 | - |
| 2026-01-31 | Ms. Jolanda HoweSenior VP & Global Controller | 803,00 | 0,00 | Derivative Exercise and Retained Stock | - | 4,50k | 21,70% |
| 2026-01-31 | Ms. Jolanda HoweSenior VP & Global Controller | -968,00 | 100,00k | Derivative Exercise and Sale | 103,30 | 4,50k | - |
| 2026-02-02 | Mr. Christopher PeetzCEO & Director | -9,11k | 940,89k | Vente | 103,30 | 347,79k | -2,55% |
| 2026-02-02 | Mr. Peter RadovichCOO & President | -2,63k | 271,79k | Vente | 103,30 | 20,66k | -11,30% |
| 2026-01-23 | Mr. Christopher PeetzCEO & Director | 5,67k | 0,00 | Derivative Exercise and Retained Stock | - | 340,24k | 1,69% |
| 2026-01-23 | Mr. Christopher PeetzCEO & Director | -6,83k | 657,09k | Derivative Exercise and Sale | 96,19 | 340,24k | - |
| 2026-01-23 | Mr. Peter RadovichCOO & President | 2,61k | 0,00 | Derivative Exercise and Retained Stock | - | 18,47k | 16,43% |
| 2026-01-23 | Mr. Peter RadovichCOO & President | -3,14k | 302,33k | Derivative Exercise and Sale | 96,19 | 18,47k | - |
| 2026-01-23 | Mr. Eric H. BjerkholtCFO | 1,61k | 0,00 | Derivative Exercise and Retained Stock | - | 43,74k | 3,83% |
| 2026-01-23 | Mr. Eric H. BjerkholtCFO | -1,05k | 101,29k | Derivative Exercise and Sale | 96,19 | 43,74k | - |
| 2026-01-23 | Ms. Jolanda HoweSenior VP & Global Controller | 658,00 | 0,00 | Derivative Exercise and Retained Stock | - | 3,70k | 21,63% |
| 2026-01-23 | Ms. Jolanda HoweSenior VP & Global Controller | -842,00 | 80,99k | Derivative Exercise and Sale | 96,19 | 3,70k | - |
| 2026-01-23 | Frazier Life Sciences Management, LPSociété | 131,43k | 9,00M | Achat | 68,48 | 7,09M | 1,89% |
| 2026-01-23 | Frazier Life Sciences Management, LPSociété | 593,86k | 21,03M | Achat | 68,48 | 1,14M | 108,97% |
| 2026-01-21 | Dr. Joanne M. J. QuanChief Medical Officer | 1,51k | 0,00 | Derivative Exercise and Retained Stock | - | 12,82k | 13,37% |
| 2026-01-21 | Dr. Joanne M. J. QuanChief Medical Officer | -1,82k | 170,04k | Derivative Exercise and Sale | 93,33 | 12,82k | - |
| 2026-01-21 | Ms. Jolanda HoweSenior VP & Global Controller | 616,00 | 0,00 | Derivative Exercise and Retained Stock | - | 3,04k | 25,39% |
| 2026-01-21 | Ms. Jolanda HoweSenior VP & Global Controller | -926,00 | 86,42k | Derivative Exercise and Sale | 93,33 | 3,04k | - |
| 2026-01-21 | Mr. Peter RadovichCOO & President | -2,38k | 222,30k | Derivative Exercise and Sale | 93,33 | 11,68k | - |
| 2026-01-21 | Mr. Peter RadovichCOO & President | 1,79k | 0,00 | Derivative Exercise and Retained Stock | - | 11,68k | 18,04% |
| 2026-01-21 | Mr. Eric H. BjerkholtCFO | 1,91k | 0,00 | Derivative Exercise and Retained Stock | - | 42,13k | 4,76% |
| 2026-01-21 | Mr. Eric H. BjerkholtCFO | -1,42k | 132,62k | Derivative Exercise and Sale | 93,33 | 42,13k | - |
| 2026-01-21 | Mr. Christopher PeetzCEO & Director | 5,70k | 0,00 | Derivative Exercise and Retained Stock | - | 334,57k | 1,73% |
| 2026-01-21 | Mr. Christopher PeetzCEO & Director | -7,10k | 662,42k | Derivative Exercise and Sale | 93,33 | 334,57k | - |
| 2026-01-16 | Dr. Joanne M. J. QuanChief Medical Officer | 5,59k | 0,00 | Derivative Exercise and Retained Stock | - | 11,31k | 97,78% |
| 2026-01-16 | Dr. Joanne M. J. QuanChief Medical Officer | -6,91k | 623,85k | Derivative Exercise and Sale | 90,27 | 11,31k | - |
| 2026-01-15 | Ms. Sona Saira Gonsalves RamasastryIndependent Director | -2,00k | 134,96k | Derivative Exercise and Sale | 23,51 - 90,99 | 0,00 | - |
| 2025-12-31 | Mr. Christopher PeetzCEO & Director | -21,07k | 0,00 | Other Disposition | - | 331,16k | -5,98% |
| 2025-12-22 | Ms. Sona Saira Gonsalves RamasastryIndependent Director | -5,00k | 282,45k | Derivative Exercise and Sale | 23,51 - 80,00 | 0,00 | - |
| 2025-12-19 | Mr. Michael G. GreyIndependent Non-Executive Chairman of the Board | -50,00k | 3,75M | Derivative Exercise and Sale | 2,94 - 78,00 | 280,16k | - |
| 2025-12-18 | Ms. Sona Saira Gonsalves RamasastryIndependent Director | -2,00k | 92,44k | Derivative Exercise and Sale | 23,51 - 70,00 | 0,00 | - |
| 2025-12-01 | Mr. Michael G. GreyIndependent Non-Executive Chairman of the Board | -50,00k | 3,55M | Derivative Exercise and Sale | 2,94 - 74,00 | 280,16k | - |
| 2025-11-21 | Mr. Michael G. GreyIndependent Non-Executive Chairman of the Board | -50,00k | 3,35M | Derivative Exercise and Sale | 2,94 - 70,00 | 280,16k | - |
| 2025-11-18 | Mr. Christopher PeetzCEO & Director | 19,13k | 368,12k | Derivative Exercise and Retained Stock | 19,24 | 349,31k | 5,79% |
| 2025-11-01 | Frazier Life Sciences Public Overage Fund, L.P.Société | -940,57k | 0,00 | Vente | - | 0,00 | -100,00% |
| 2025-11-01 | Frazier Life Sciences Management, LPSociété | 940,57k | 0,00 | Achat | - | 2,51M | 59,74% |
| 2025-09-11 | Mr. Eric H. BjerkholtCFO | 8,76k | 0,00 | Derivative Exercise and Retained Stock | - | 39,95k | 28,07% |
| 2025-09-11 | Mr. Eric H. BjerkholtCFO | -9,58k | 728,02k | Derivative Exercise and Sale | 76,01 | 39,95k | - |
| 2025-09-11 | Ms. Laura A. BregeIndependent Director | -17,00k | 1,01M | Derivative Exercise and Sale | 15,00 - 75,07 | 15,70k | - |
| 2025-09-08 | Ms. Sona Saira Gonsalves RamasastryIndependent Director | -17,00k | 399,67k | Derivative Exercise and Sale | - | 0,00 | - |
| 2025-08-12 | Mr. Eric H. BjerkholtCFO | 2,95k | 78,25k | Derivative Exercise and Retained Stock | 26,49 | 31,19k | 10,46% |
| 2025-08-11 | Mr. Eric H. BjerkholtCFO | -8,00k | 0,00 | Vente | - | 31,19k | -20,41% |
| 2025-08-11 | Mr. Christopher PeetzCEO & Director | -40,00k | 2,36M | Derivative Exercise and Sale | 2,94 - 62,00 | 324,29k | - |
| 2025-08-07 | Ms. Jolanda HoweSenior VP & Global Controller | -10,00k | 517,30k | Derivative Exercise and Sale | 6,27 - 58,00 | 2,43k | - |
| 2025-08-07 | Mr. Christopher PeetzCEO & Director | -40,00k | 2,09M | Derivative Exercise and Sale | 2,94 - 55,25 | 324,29k | - |
| 2025-07-01 | Ms. Jolanda HoweSenior VP & Global Controller | -1,04k | 50,62k | Derivative Exercise and Sale | 48,25 - 49,08 | 2,43k | - |
| 2025-06-11 | Mr. William Carl FaireyIndependent Director | -3,20k | 155,09k | Vente | 48,42 | 2,50k | -56,16% |
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