Major Progress in Anadis' Milk-Based Anti-Influenza (Flu) Virus Antibodies Project
08 Janvier 2008 - 5:02AM
Business Wire
Anadis Limited (ASX:ANX; OTC: ANDIY), today announced major
progress in its anti-flu virus antibody program. The milk- derived
anti-flu virus antibodies are all-natural and will provide
immediate-acting immune enhancement once deposited topically on
mucosal surfaces that come in contact with the influenza virus.
Results from human trials are anticipated within 18 months.
Addressing both seasonal and avian influenza (bird flu) virus
strains, Anadis plans to introduce products using these antibodies
(Flubodies) into the market within 2-3 years. This decision follows
several successful animal trials with mice, conducted by Anadis and
an internationally-recognized influenza research group at the
University of Melbourne led by Professor Lorena Brown, using
recognized pathways for development of anti-avian flu virus
treatments. The dairy derived anti-flu virus antibody significantly
decreased disease mortality and were significantly interrupting the
disease process after challenges with lethal doses of virus. Anadis
prototype milk-derived hyperimmune antibody preparation ("flubody")
improved the survival rate of infected mice (exposed to lethal flu)
from 0% in non-treated mice to up to 60% in treated mice. In other
trials, it was shown that the progress of disease could be delayed
for days with a single application of the prototype formulation.
�This series of new preclinical tests gives us the comfort level to
accelerate and the commercialization of our revolutionary Flubody
approach for halting viral spread, utilizing our patent pending
antibody formulations to provide immediate acting immunity� ,� said
Dr Zeil Rosenberg, Anadis CEO. �Antibody and other protein-based
solutions represent the next generation in the fight against
influenza and Anadis, with its rapid development effort and
extremely low manufacturing cost for harvesting antibodies, is
well-positioned to benefit from this trend.� Influenza affects
15-60 million people in the United States each year, causing an
estimated 44,000 deaths and 186,000 hospitalizations annually.
Pandemic influenza has occurred three times over the last century.
The 1918 outbreak alone killed more than 40 million people
worldwide. Avian influenza (bird flu) is a lethal influenza strain
that has created worldwide concern because its infection can be
transferred among humans. The mortality rate among humans exceeds
50%. Dr. Oren Fuerst, VP of Business Development of the company
said: " Benefiting from our years of experience in the harvesting
of polyclonal antibodies and other fractions of dairy derived
immune milk (colostrum), we aim to be first to market with an
effective and patented formulation for both the routine and avian
flu markets. With our unique approach, we plan to become world
leaders in the influenza market that today already exceeds $5
billion worldwide.� Anadis Limited (ASX: ANX; OTC: ANDIY) is a
biopharmaceutical company focused on antigen-primed, dairy-derived
health products. Anadis� proprietary, rapid manufacturing
technology has enabled it to develop a product pipeline of
polyclonal antibody-based solutions to a range of important
infectious and immune-mediated diseases. The all-natural
colostrum-derived platform, and its regulatory classification as
GRAS (Generally Regarded as Safe) when administered orally, allows
for a significantly shorter time-frame from bench to market
compared with typical biotechnology products. The platform also
possesses dramatically lower manufacturing costs and higher
scalability compared to typical antibody-based solutions. Anadis is
addressing existing market opportunities sized in excess of US$30
billion. Leveraging a technology platform that has been carefully
developed over a decade, the company expects to become the leading
provider of proprietary polyclonal antibody-based solutions
worldwide.
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