DOCUMENT TYPE SC 13G
TEXT


SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
Under the Securities Exchange Act of 1934


Name of Issuer: ALLOS THERAPEUTICS INC
_____________________________________________________
Title of Class
of Securities: Common Stock

CUSIP Number: 019777101

1) NAME AND I.R.S. IDENTIFICATION NO. OF REPORTING PERSON

Prudential Financial, Inc. 22-3703799

2.) MEMBER OF A GROUP: (a) N/A
(b) N/A

3) SEC USE ONLY:



4) PLACE OF ORGANIZATION: New Jersey

NUMBER OF SHARES BENEFICIALLY OWNED BY REPORTING PERSON WITH:

5) Sole Voting Power: 0 See Exhibit A
6) Shared Voting Power: 3,758,100 See Exhibit A
7) Sole Dispositive Power: 0 See Exhibit A
8) Shared Dispositive Power: 3,758,100 See Exhibit A

9) AGGREGATE AMOUNT BENEFICIALLY OWNED:
3,758,100 See Exhibit A

10) AGGREGATE AMOUNT IN ROW (9) EXCLUDES SHARES: Not Applicable

11) PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9):
5.6 See Exhibit A

12) TYPE OF REPORTING PERSON: HC

ITEM 1(a). NAME OF ISSUER:

ALLOS THERAPEUTICS INC

ITEM 1(b). ADDRESS OF ISSUER'S EXECUTIVE OFFICES:

ALLOS THERAPEUTICS INC 11080 Circlepoint Road Suite 200 Westminster, CO 80020

ITEM 2(a). NAME OF PERSON FILING:

Prudential Financial, Inc.

ITEM 2(b). ADDRESS OF PRINCIPAL BUSINESS OFFICE:

751 Broad Street
Newark, New Jersey 07102-3777

ITEM 2(c). CITIZENSHIP:

New Jersey

ITEM 2(d). TITLE OF CLASS OF SECURITIES:

Common Stock

ITEM 2(e). CUSIP NUMBER:

019777101

ITEM 3. The Person filing this statement is a Parent Holding Company as
defined in Section 240.13d-1(b)(1)(ii)(G) of the Securities Exchange
Act of 1934.

ITEM 4. OWNERSHIP:

(a) Number of Shares
Beneficially Owned: 3,758,100 See Exhibit A

(b) Percent of Class: 5.6


(c) Powers No. Of Shares
----------- --------------------
Sole power to vote or 0 See Exhibit A to direct the vote
Shared power to vote or 3,758,100 See Exhibit A to direct the vote
Sole power to dispose or 0 See Exhibit A to direct disposition
Shared power to dispose 3,758,100 See Exhibit A or to direct disposition

ITEM 5. OWNERSHIP OF 5% OR LESS OF A CLASS:

Not Applicable

ITEM 6. OWNERSHIP OF MORE THAN 5% ON BEHALF OF
ANOTHER PERSON:

See Exhibit A

ITEM 7. IDENTIFICATION AND CLASSIFICATION OF THE
SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING
REPORTED ON BY THE ULTIMATE PARENT COMPANY:

See Exhibit A

ITEM 8. IDENTIFICATION AND CLASSIFICATION OF
MEMBERS OF THE GROUP:

Not Applicable

ITEM 9. NOTICE OF DISSOLUTION OF GROUP:

Not Applicable

ITEM 10. CERTIFICATION:

By signing below, Prudential Financial, Inc. certifies that, to the best of its
knowledge and belief, the securities referred to above were acquired
and are held in the ordinary course of business and were not acquired
and are not held for the purpose of or with the effect of changing or
influencing the control of the issuer of the securities and were not acquired
and are not held in connection with or as a participant in any transaction
having that purpose or effect.


The filing of this statement should not be construed as an admission that
Prudential Financial, Inc. is, for purposes of Sections 13 or 16 of the Securities
Exchange Act of 1934, the beneficial owner of such shares.


SIGNATURE

After reasonable inquiry and to the best of its knowledge and belief,
Prudential Financial, Inc. certifies that the information set forth in this
statement is true, complete and correct.

PRUDENTIAL FINANCIAL, INC.

By: Frank Adamo
Second Vice President

Date: 02/06/2008
As of: 12/31/2007

Exhibit A
--------------

ITEM 6. OWNERSHIP:

Prudential Financial, Inc. may be deemed the beneficial owner of securities
beneficially owned by the Item 7 listed entities and may have direct or
indirect voting and/or investment discretion over 3,758,100 shares which are
held for it's own benefit or for the benefit of its clients by its separate
accounts, externally managed accounts, registered investment companies,
subsidiaries and/or other affiliates. Prudential Financial, Inc. is reporting
the combined holdings of these entities for the purpose of administrative
convenience.

These shares were acquired in the ordinary course of business, and not with the
purpose or effect of changing or influencing control of the Issuer. The filing
of this statement should not be construed as an admission that Prudential
Financial, Inc. is, for the purposes of Sections 13 or 16 of the Securities
Exchange Act of 1934, the beneficial owner of these shares.


ITEM 7. IDENTIFICATION/CLASSIFICATION:

Prudential Financial, Inc. is a Parent Holding Company and the direct or indirect parent of the following Registered Investment Advisers and Broker Dealers:



 The Prudential Insurance Company of America IC,IA
 Prudential Investment Management, Inc. IA
 Jennison Associates LLC IA
 Pramerica Asset Management, Inc. IA
 Prudential Investments LLC IA
 Prudential Private Placement Investors, L.P. IA,PN
 PRUCO Securities, LLC IA,BD
 Prudential Investment Management Services LLC BD
 Prudential Equity Group, LLC. BD
 American Skandia Investment Services, Inc. IA
 American Skandia Marketing, Inc. BD
 Quantitative Management Associates LLC IA
 Prudential International Investments Advisers, LLC IA
 Global Portfolio Strategies, Inc. IA
 Pru Global Securities, LLC BD
 Prudential Financial Derivatives, LLC BD


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