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| Date | Nom du détenteur | Actions transigées | Fourchette de valeur ($) | Type d'opération | Fourchette de prix ($) | Actions en fin de déclaration | % de variation |
|---|---|---|---|---|---|---|---|
| 2026-06-01 | Ms. Alexandra BalcomCFO & Treasurer | -11,43k | 1,05M | Derivative Exercise and Sale | 6,89 - 103,84 | 85,53k | - |
| 2026-05-28 | Ms. Darlene NociChief Development Officer | -5,50k | 439,75k | Derivative Exercise and Sale | 27,85 - 109,76 | 17,02k | - |
| 2026-05-28 | Ms. Deborah Ann MillerChief Legal Officer & Secretary | -5,50k | 555,21k | Derivative Exercise and Sale | 6,89 - 109,30 | 18,53k | - |
| 2026-05-04 | Dr. James R. PorterCEO, President & Director | -30,00k | 2,48M | Derivative Exercise and Sale | 18,93 - 102,88 | 203,53k | - |
| 2026-05-01 | Ms. Alexandra BalcomCFO & Treasurer | -11,43k | 1,09M | Derivative Exercise and Sale | 1,08 - 99,97 | 85,53k | - |
| 2026-04-30 | Ms. Deborah Ann MillerChief Legal Officer & Secretary | -5,50k | 507,80k | Derivative Exercise and Sale | 6,89 - 99,57 | 18,53k | - |
| 2026-04-29 | Ms. Darlene NociChief Development Officer | -5,50k | 394,35k | Derivative Exercise and Sale | 27,85 - 101,17 | 17,02k | - |
| 2026-04-09 | Dr. Henry PelishChief Scientific Officer | -3,09k | 237,02k | Derivative Exercise and Sale | 27,85 - 105,00 | 20,14k | - |
| 2026-04-06 | Dr. James R. PorterCEO, President & Director | -30,00k | 2,40M | Derivative Exercise and Sale | 18,93 - 105,60 | 203,53k | - |
| 2026-04-01 | Ms. Alexandra BalcomCFO & Treasurer | -11,43k | 1,19M | Derivative Exercise and Sale | 1,08 - 106,18 | 85,53k | - |
| 2026-03-30 | Ms. Darlene NociChief Development Officer | -5,50k | 384,77k | Derivative Exercise and Sale | 27,85 - 98,13 | 17,02k | - |
| 2026-03-26 | Ms. Deborah Ann MillerChief Legal Officer & Secretary | -5,50k | 505,10k | Derivative Exercise and Sale | 6,89 - 99,46 | 18,53k | - |
| 2026-03-25 | Ms. Alexandra BalcomCFO & Treasurer | -13,70k | 1,37M | Automatic Disposition | 100,16 | 44,43k | -23,57% |
| 2026-03-24 | Ms. Alexandra BalcomCFO & Treasurer | -11,43k | 1,08M | Derivative Exercise and Sale | 1,08 - 96,50 | 44,43k | - |
| 2026-03-12 | Dr. Henry PelishChief Scientific Officer | -17,32k | 1,15M | Derivative Exercise and Sale | 18,93 - 97,79 | 20,14k | - |
| 2026-03-12 | Dr. Henry PelishChief Scientific Officer | -17,78k | 1,75M | Automatic Disposition | 97,79 - 99,71 | 20,14k | -46,90% |
| 2026-03-06 | Dr. James R. PorterCEO, President & Director | -30,00k | 2,13M | Derivative Exercise and Sale | 27,85 - 100,19 | 203,53k | - |
| 2026-02-26 | Ms. Darlene NociChief Development Officer | -5,50k | 413,51k | Derivative Exercise and Sale | 27,85 - 104,25 | 17,02k | - |
| 2026-02-26 | Ms. Deborah Ann MillerChief Legal Officer & Secretary | -5,50k | 528,89k | Derivative Exercise and Sale | 6,89 - 103,96 | 18,53k | - |
| 2026-01-29 | Ms. Darlene NociChief Development Officer | -5,50k | 408,25k | Derivative Exercise and Sale | 27,85 - 103,39 | 17,02k | - |
| 2026-01-21 | Ms. Deborah Ann MillerChief Legal Officer & Secretary | -15,00k | 1,23M | Derivative Exercise and Sale | 27,85 - 110,16 | 18,53k | - |
| 2026-01-05 | Ms. Deborah Ann MillerChief Legal Officer & Secretary | -6,95k | 676,16k | Vente | 96,06 - 98,52 | 18,53k | -27,28% |
| 2026-01-05 | Ms. Darlene NociChief Development Officer | -7,42k | 721,32k | Vente | 96,06 - 98,52 | 17,02k | -30,36% |
| 2026-01-05 | Dr. Henry PelishChief Scientific Officer | -5,16k | 501,75k | Vente | 96,06 - 98,52 | 24,46k | -17,42% |
| 2026-01-05 | Ms. Alexandra BalcomCFO & Treasurer | -7,42k | 721,32k | Vente | 96,06 - 98,52 | 58,13k | -11,32% |
| 2026-01-05 | Dr. Christopher D. TurnerChief Medical Officer | -7,42k | 721,32k | Vente | 96,06 - 98,52 | 31,53k | -19,04% |
| 2026-01-05 | Dr. James R. PorterCEO, President & Director | -27,43k | 2,67M | Vente | 96,06 - 98,52 | 203,53k | -11,88% |
| 2026-01-02 | Ms. Deborah Ann MillerChief Legal Officer & Secretary | -10,00k | 815,81k | Derivative Exercise and Sale | 18,93 - 101,47 | 8,14k | - |
| 2025-12-30 | Ms. Darlene NociChief Development Officer | -4,00k | 288,78k | Derivative Exercise and Sale | 27,85 - 101,22 | 48,03k | - |
| 2025-12-22 | Ms. Alexandra BalcomCFO & Treasurer | 34,50k | 37,26k | Derivative Exercise and Retained Stock | 1,08 | 48,20k | 251,82% |
| 2025-12-22 | Dr. Henry PelishChief Scientific Officer | 5,09k | 5,49k | Derivative Exercise and Retained Stock | 1,08 | 30,10k | 20,33% |
| 2025-12-19 | Dr. James R. PorterCEO, President & Director | 57,00k | 37,05k | Derivative Exercise and Retained Stock | 0,65 | 174,61k | 48,46% |
| 2025-12-08 | Ms. Alexandra BalcomCFO & Treasurer | -7,08k | 781,54k | Automatic Disposition | 110,31 - 111,32 | 13,70k | -34,08% |
| 2025-11-28 | Ms. Darlene NociChief Development Officer | -4,00k | 322,92k | Derivative Exercise and Sale | 27,85 - 108,72 | 48,03k | - |
| 2025-11-24 | Prof. Matthew D. ShairInitié | -7,50k | 820,27k | Automatic Disposition | 107,70 - 110,42 | 1,58M | -0,47% |
| 2025-11-24 | Deerfield Management Company, L.P.Société | -742,57k | 70,87M | Vente | 95,45 | 17,25M | -4,13% |
| 2025-11-17 | Ms. Deborah Ann MillerChief Legal Officer & Secretary | -24,20k | 2,39M | Derivative Exercise and Sale | 6,89 - 107,04 | 8,14k | - |
| 2025-11-17 | Ms. Alexandra BalcomCFO & Treasurer | -20,73k | 1,02M | Derivative Exercise and Sale | 6,89 - 104,54 | 20,78k | - |
| 2025-10-30 | Ms. Deborah Ann MillerChief Legal Officer & Secretary | -21,80k | 2,10M | Derivative Exercise and Sale | 6,89 - 104,78 | 8,14k | - |
| 2025-10-30 | Ms. Darlene NociChief Development Officer | -4,00k | 300,26k | Derivative Exercise and Sale | 27,85 - 104,58 | 48,03k | - |
| 2025-10-27 | Prof. Matthew D. ShairInitié | -60,00k | 6,02M | Automatic Disposition | 100,23 - 100,27 | 1,58M | -3,65% |
| 2025-10-20 | Ms. Deborah Ann MillerChief Legal Officer & Secretary | -5,00k | 440,10k | Derivative Exercise and Sale | 6,89 - 94,91 | 8,14k | - |
| 2025-10-16 | Dr. James R. PorterCEO, President & Director | -27,00k | 1,94M | Derivative Exercise and Sale | 18,93 - 92,63 | 117,61k | - |
| 2025-10-15 | Dr. Henry PelishChief Scientific Officer | -14,21k | 780,76k | Derivative Exercise and Sale | 18,93 - 90,04 | 25,01k | - |
| 2025-10-15 | Ms. Deborah Ann MillerChief Legal Officer & Secretary | -28,00k | 2,35M | Derivative Exercise and Sale | 6,89 - 92,50 | 8,14k | - |
| 2025-10-15 | Ms. Alexandra BalcomCFO & Treasurer | -1,68k | 112,16k | Derivative Exercise and Sale | 18,93 - 85,57 | 20,78k | - |
| 2025-10-13 | Dr. Henry PelishChief Scientific Officer | -10,07k | 554,22k | Derivative Exercise and Sale | 18,93 - 89,81 | 25,01k | - |
| 2025-10-13 | Ms. Alexandra BalcomCFO & Treasurer | -40,00k | 2,82M | Derivative Exercise and Sale | 6,89 - 89,22 | 20,78k | - |
| 2025-10-01 | Ms. Alexandra BalcomCFO & Treasurer | -20,00k | 1,53M | Derivative Exercise and Sale | 6,89 - 86,37 | 20,78k | - |
| 2025-09-29 | Ms. Alexandra BalcomCFO & Treasurer | -27,59k | 2,16M | Derivative Exercise and Sale | 6,89 - 85,06 | 20,78k | - |
| 2025-09-29 | Ms. Darlene NociChief Development Officer | -4,00k | 220,89k | Derivative Exercise and Sale | 27,85 - 84,92 | 7,08k | - |
| 2025-09-15 | Dr. James R. PorterCEO, President & Director | -27,00k | 1,62M | Derivative Exercise and Sale | 18,93 - 80,12 | 117,61k | - |
| 2025-09-10 | Dr. Henry PelishChief Scientific Officer | -3,73k | 193,29k | Derivative Exercise and Sale | 18,93 - 78,83 | 25,01k | - |
| 2025-08-29 | Dr. Henry PelishChief Scientific Officer | 5,01k | 4,99k | Derivative Exercise and Retained Stock | 0,87 - 1,08 | 38,48k | 14,96% |
| 2025-08-25 | Ms. Darlene NociChief Development Officer | -4,00k | 187,09k | Derivative Exercise and Sale | 27,85 - 75,63 | 7,08k | - |
| 2025-08-15 | Dr. James R. PorterCEO, President & Director | -27,00k | 1,53M | Derivative Exercise and Sale | 18,93 - 76,90 | 117,61k | - |
| 2025-08-07 | Dr. Henry PelishChief Scientific Officer | -5,50k | 259,26k | Derivative Exercise and Sale | 18,93 - 74,85 | 20,01k | - |
| 2025-07-30 | Ms. Darlene NociChief Development Officer | -4,00k | 210,04k | Derivative Exercise and Sale | 27,85 - 80,36 | 7,08k | - |
| 2025-07-15 | Ms. Alexandra BalcomCFO & Treasurer | -20,00k | 1,31M | Derivative Exercise and Sale | 18,93 - 85,48 | 20,78k | - |
| 2025-07-15 | Dr. James R. PorterCEO, President & Director | -27,00k | 1,71M | Derivative Exercise and Sale | 18,93 - 84,53 | 117,61k | - |
| 2025-07-10 | Dr. Henry PelishChief Scientific Officer | -5,50k | 281,78k | Derivative Exercise and Sale | 18,93 - 80,92 | 20,01k | - |
| 2025-07-09 | Dr. Henry PelishChief Scientific Officer | -2,15k | 174,08k | Automatic Disposition | 81,08 - 81,90 | 20,01k | -9,68% |
| 2025-06-27 | Ms. Alexandra BalcomCFO & Treasurer | -20,00k | 1,22M | Derivative Exercise and Sale | 18,93 - 80,02 | 20,78k | - |
| 2025-06-26 | Ms. Darlene NociChief Development Officer | -4,00k | 203,43k | Derivative Exercise and Sale | 27,85 - 79,15 | 7,08k | - |
| 2025-06-25 | Dr. Henry PelishChief Scientific Officer | -10,80k | 551,90k | Derivative Exercise and Sale | 27,85 - 79,92 | 17,78k | - |
| 2025-06-16 | Dr. James R. PorterCEO, President & Director | -27,00k | 1,33M | Derivative Exercise and Sale | 27,85 - 78,22 | 117,61k | - |
| 2025-06-06 | Dr. Henry PelishChief Scientific Officer | -200,00 | 10,25k | Derivative Exercise and Sale | 27,85 - 79,82 | 17,78k | - |
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