RNS Number:6633T
Alizyme PLC
24 December 2003


                                  SCHEDULE 10


                   NOTIFICATION OF MAJOR INTERESTS IN SHARES


1. Name of company

Alizyme plc


2. Name of shareholder having a major interest

(i) FMR Corp.
82 Devonshire Street
Boston, MA 02109

Parent holding company of Fidelity Management & Research Company (FMRCO),
investment manager for US mutual funds.

(ii) Fidelity International Limited (FIL)
P.O. Box HM 670
Hamilton HMCX, Bermuda

Parent holding company for various direct and indirect subsidiaries, including
Fidelity Investment Services Ltd. (FISL) investment manager for various non-US
investment companies and institutional clients.

(iii) The notifiable interests also comprise the notifiable interest of:

Mr Edward C. Johnson 3d
82 Devonshire Street
Boston, MA 02109

A principal shareholder of FMR Corp. and Fidelity International Limited.



3. Please state whether notification indicates that it is in respect of holding
of the shareholder named in 2 above or in respect of a non-beneficial interest
or in the case of an individual holder if it is a holding of that person's
spouse or children under the age of 18

Shareholders named at No.2











4. Name of the registered holder(s) and, if more than one holder, the number of
shares held by each of them

Shares Held              Management Company                     Nominee/Registered Name

   1,715,900   Fidelity Management & Research Company                     HSBC

   1,783,289      Fidelity Investment Services Ltd.           Chase Manhattan Bank London

   3,702,062   Fidelity International Limited            HSBC Client Holdings Nominee (UK) Ltd

     162,400   Fidelity International Limited                 Chase Manhattan Bank London

      34,119   Fidelity International Limited                  State Street Bank & Trust



5. Number of shares / amount of stock acquired

                                                                     1,232,629


6. Percentage of issued class

                                                                          0.85%


7. Number of shares / amount of stock disposed

N/A


8. Percentage of issued class

N/A


9. Class of security

Ordinary Shares of 2p each


10. Date of transaction

Unknown


11. Date company informed

23 December 2003


12. Total holding following this notification

                                                                     7,397,770



13. Total percentage holding of issued class following this notification

                                                                          5.13%


14. Any additional information

These notifications of disclosable interests constitute separate notifications
of interest in the shares and are combined solely for the purposes of clarity
and efficiency. Nothing herein should be taken to indicate that FMR Corp. and
its direct and indirect subsidiaries, Fidelity International Limited and its
direct and indirect subsidiaries or Mr Edward C. Johnson 3d act as a group or in
concert
in respect of the disclosed interests, or that they are required to submit these
notifications on a joint basis.


15. Name of contact and telephone number for queries

Mr Tim McCarthy 01223 896 000


16. Name and signature of authorised company official responsible for making
this notification

Tim McCarthy


Date of notification

24 December 2003


The FSA does not give any express or implied warranty as to the accuracy of this
document or material and does not accept any liability for error or omission.
The FSA is not liable for any damages (including, without limitation, damages
for loss of business or loss of profits) arising in contract, tort or otherwise
from the use of or inability to use this document, or any material contained in
it, or from any action or decision taken as a result of using this document or
any such material.



                      This information is provided by RNS
            The company news service from the London Stock Exchange

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