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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
__________________________________________
FORM 8-K
__________________________________________
CURRENT REPORT
PURSUANT TO SECTION 13 OR 15(d)
OF THE SECURITIES EXCHANGE ACT OF 1934
Date of Report (Date of earliest event reported): February 27, 2025
__________________________________________
AbCellera Biologics Inc.
(Exact name of registrant as specified in its charter)
__________________________________________
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British Columbia | 001-39781 | Not Applicable |
(State or other jurisdiction of incorporation) | (Commission File Number) | (IRS Employer Identification Number) |
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150 W 4th Avenue Vancouver, BC | V5Y 1G6 |
(Address of registrant’s principal executive office) | (Zip code) |
(604) 559-9005
(Registrant’s telephone number, including area code)
(Former name or former address, if changed since last report)
__________________________________________
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
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o | | Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) |
o | | Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) |
o | | Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) |
o | | Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) |
Securities registered pursuant to Section 12(b) of the Act:
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Title of each class | Trading symbol(s) | Name of each exchange on which registered |
Common shares | ABCL | The Nasdaq Stock Market LLC |
Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 or Rule 12b-2 of the Securities Exchange Act of 1934.
Emerging growth company o
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. o
Item 2.02 Results of Operations and Financial Condition
On February 27, 2025, AbCellera Biologics Inc. (the “Company”), issued a press release announcing its financial and operational results for the year ended December 31, 2024. A copy of the press release is furnished herewith as Exhibit 99.1.
Item 7.01 Regulation FD Disclosure
In connection with its earnings call on February 27, 2025, to discuss its results for the year ended December 31, 2024, the Company will utilize a corporate presentation, a copy of which is furnished herewith as Exhibit 99.2.
The information in Items 2.02 and 7.01 of this Form 8-K (including the exhibits attached hereto) is being furnished and shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liability of that section, nor shall such information be deemed to be incorporated by reference in any registration statement or other document filed under the Securities Act of 1933, as amended, or the Exchange Act, except as otherwise stated in such filing.
Item 9.01 Financial Statements and Exhibits
(d)Exhibits
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Exhibit No. | | Description |
99.1 | | |
99.2 | | |
104 | | Cover Page Interactive Data File (embedded as Inline XBRL document) |
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
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Date: February 27, 2025 | ABCELLERA BIOLOGICS INC. |
| | |
| By: | /s/ Carl L. G. Hansen |
| | Carl L. G. Hansen, Ph.D. |
| | Chief Executive Officer and Director (Principal Executive Officer) |
NEWS RELEASE
AbCellera Reports Full Year 2024 Business Results
2/27/2025
VANCOUVER, British Columbia--(BUSINESS WIRE)-- AbCellera (Nasdaq: ABCL) today announced financial results for the full year 2024. All financial information in this press release is reported in U.S. dollars, unless otherwise indicated.
“In 2024 we made significant progress in transitioning from a platform company to a clinical-stage biotech, including advancing our internal pipeline and completing significant investments in our capabilities. We also maintained our strong cash position, closing the year with over $800 million in available liquidity to execute on our strategy,” said Carl Hansen, Ph.D., founder and CEO of AbCellera. “As a result, we enter 2025 on track to initiate Phase 1 clinical trials for our first two programs, ABCL635 and ABCL575, and to start activities in our new clinical manufacturing facility.”
FY 2024 Business Summary
●Earned $28.8 million in total revenue.
●Generated a net loss of $162.9 million, compared to net loss of $146.4 million in 2023.
●Reached a cumulative total of 96 partner-initiated program starts with downstreams.
●Reporting the advancement of three additional molecules in the clinic, bringing the cumulative total to 16 molecules to have reached the clinic.
Key Business Metrics
| | | | | | | | | | | | | | |
Cumulative Metrics | | December 31, 2023 | | December 31, 2024 | | Change % |
Partner-initiated program starts with downstreams | | 87 | | 96 | | 10 | % |
Molecules in the clinic | | 13 | | 16 | | 23 | % |
AbCellera started discovery on an additional nine partner-initiated programs with downstreams to reach a cumulative total of 96 partner-initiated program starts with downstreams in 2024 (up from 87 on December 31, 2023). AbCellera’s partners have advanced a cumulative total of 16 molecules into the clinic (up from 13 on December 31, 2023).
Discussion of FY 2024 Financial Results
●Revenue – Total revenue was $28.8 million, compared to $38.0 million in 2023. In both periods, the majority of revenues were research fees generated by our partnerships.
●Research & Development (R&D) Expenses – R&D expenses were $167.3 million, compared to $175.7 million in 2023, reflecting underlying continued growth in program execution, platform development, and investments in internal programs.
●Sales & Marketing (S&M) Expenses – S&M expenses were $12.8 million, compared to $14.2 million in 2023.
●General & Administrative (G&A) Expenses – G&A expenses were $72.7 million, compared to $61.0 million in 2023.
●Net Loss – Net loss of $162.9 million, or $(0.55) per share on a basic and diluted basis, compared to net loss of $146.4 million, or $(0.51) per share on a basic and diluted basis, in 2023.
●Liquidity – $652.9 million of total cash, cash equivalents, and marketable securities and approximately $186 million in available non-dilutive government funding, bringing total available liquidity to approximately $840 million to execute on AbCellera's strategy.
Q4 Highlights and Financial Results
●Abdera advanced ABD-147 into a Phase 1 clinical trial. AbCellera is a founding partner in Abdera, has a low-single-digit royalty stake in Abdera’s programs, and has a mid-single-digit equity ownership position.
●Reporting the advancement of two Trianni-license molecules into the clinic.
●Started one partner-initiated program with downstreams.
●Revenue for the fourth quarter of 2024 was $5.1 million, the majority of which was research fees generated by our partnerships, representing 18% of total revenue for 2024.
●Operating expenses totaled $77.8 million in the fourth quarter, or 23% of the total for 2024, and included investments made in co-development and internal programs.
●The net loss for the fourth quarter was $34.2 million, or $(0.12) per share, on a basic and diluted basis.
Conference Call and Webcast
AbCellera will host a conference call and live webcast to discuss these results today at 2:00 p.m. Pacific Time (5:00 p.m. Eastern Time).
The live webcast of the earnings conference call can be accessed on the Events and Presentations section of AbCellera’s Investor Relations website. A replay of the webcast will be available through the same link following the conference call.
About AbCellera Biologics Inc.
AbCellera (Nasdaq: ABCL) discovers and develops antibody medicines for indications across therapeutic areas including cancer, metabolic and endocrine conditions, and autoimmune disorders. AbCellera integrates technology, data science, infrastructure, and interdisciplinary teams to solve the most challenging antibody discovery problems. AbCellera is focused on advancing an internal pipeline of first-in-class and best-in-class programs and collaborating on innovative drug development programs with partners. For more information, please visit www.abcellera.com.
Definition of Key Business Metrics
We regularly review the following key business metrics to evaluate our business, measure our performance, identify trends affecting our business, formulate financial projections, and make strategic decisions. We believe that the following metrics are important to understand our current business. These metrics may change or may be substituted for additional or different metrics as our business develops.
Partner-initiated program starts with downstreams represent the number of unique partner-initiated programs where we stand to participate financially in downstream success for which we have commenced the discovery effort. The discovery effort commences on the later of (i) the day on which we receive sufficient reagents to start discovery of antibodies against a target and (ii) the day on which the kick-off meeting for the program is held. We view this metric as an indication of the selection and initiation of projects by our partners and the resulting potential for near-term payments. Cumulatively, partner-initiated program starts with downstream participation indicate our total opportunities to earn downstream revenue from milestone fees and royalties (or royalty equivalents) in the mid- to long-term.
Molecules in the clinic represent the count of unique molecules for which an Investigational New Drug, or IND, New Animal Drug, or equivalent under other regulatory regimes, application has reached "open" status or has otherwise been approved based on an antibody that was discovered either by us or by a partner using licensed AbCellera technology. Where the date of such application approval is not known to us, the date of the first public announcement of a clinical trial will be used for the purpose of this metric. We view this metric as an indication of our near- and mid-term potential revenue from milestone fees and potential royalty payments in the long term.
AbCellera Forward-Looking Statements
This press release contains forward-looking statements, including statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. The forward-looking statements are based on management’s current beliefs and assumptions and on information currently available to management. All statements contained in this release other than statements of historical fact are forward-looking statements, including statements regarding our ability to develop, commercialize and achieve market acceptance of our current and planned products and services, our research and development efforts, and other matters regarding our business strategies, use of capital, results of operations and financial position, and plans and objectives for future operations.
In some cases, you can identify forward-looking statements by the words “may,” “will,” “could,” “would,” “should,” “expect,” “intend,” “plan,” “anticipate,” “believe,” “estimate,” “predict,” “project,” “potential,” “continue,” “ongoing” or the negative of these terms or other comparable terminology, although not all forward-looking statements contain these words. These statements involve risks, uncertainties and other factors that may cause actual results, levels of activity, performance, or achievements to be materially different from the information expressed or implied by these forward-looking statements. These risks, uncertainties and other factors are described under “Risk Factors,” “Management's Discussion and Analysis of Financial Condition and Results of Operations” and elsewhere in the documents we file with the Securities and Exchange Commission from time to time. We caution you that forward-looking statements are based on a combination of facts and factors currently known by us and our projections of the future, about which we cannot be certain. As a result, the forward-looking statements may not prove to be accurate. The forward-looking statements in this press release represent our views as of the date hereof. We undertake no obligation to update any forward-looking statements for any reason, except as required by law.
Source: AbCellera Biologics Inc.
Inquiries
Media: Tiffany Chiu; media@abcellera.com, +1(236)521-6774
Partnering: Murray McCutcheon, Ph.D.; partnering@abcellera.com, +1(604)559-9005
Investor Relations: Peter Ahn; ir@abcellera.com, +1(778)729-9116
AbCellera Biologics Inc.
Consolidated Statements of Income (Loss) and Comprehensive Income (Loss)
(All figures in U.S. dollars. Amounts are expressed in thousands except share and per share data.)
| | | | | | | | | | | | | | | |
| | | Year ended December 31, |
| | | 2022 | | 2023 | | 2024 |
Revenue: | | | | | | | |
Research fees | | | $ | 40,802 | | | $ | 35,556 | | | $ | 26,284 | |
Licensing revenue | | | 696 | | | 969 | | | 1,049 | |
Milestone payments | | | 900 | | | 1,500 | | | 1,500 | |
Royalty revenue | | | 443,026 | | | — | | | — | |
Total revenue | | | 485,424 | | | 38,025 | | | 28,833 | |
Operating expenses: | | | | | | | |
Royalty fees | | | 66,436 | | | — | | | — | |
Research and development(1) | | | 107,879 | | | 175,658 | | | 167,259 | |
Sales and marketing(1) | | | 11,270 | | | 14,180 | | | 12,779 | |
General and administrative(1) | | | 55,485 | | | 60,999 | | | 72,711 | |
Depreciation, amortization, and impairment | | | 27,843 | | | 24,395 | | | 90,850 | |
Total operating expenses | | | 268,913 | | | 275,232 | | | 343,599 | |
Income (loss) from operations | | | 216,511 | | | (237,207) | | | (314,766) | |
Other (income) expense | | | | | | | |
Interest income | | | (16,079) | | | (42,247) | | | (38,473) | |
Grants and incentives | | | (10,554) | | | (14,155) | | | (13,620) | |
Other | | | 4,045 | | | (6,776) | | | (62,278) | |
Total other income | | | (22,588) | | | (63,178) | | | (114,371) | |
Net earnings (loss) before income tax | | | 239,099 | | | (174,029) | | | (200,395) | |
Income tax (recovery) expense | | | 80,580 | | | (27,631) | | | (37,538) | |
Net earnings (loss) | | | $ | 158,519 | | | $ | (146,398) | | | $ | (162,857) | |
Foreign currency translation adjustment | | | (1,671) | | | (329) | | | (2,658) | |
Comprehensive income (loss) | | | $ | 156,848 | | | $ | (146,727) | | | $ | (165,515) | |
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Net earnings (loss) per share | | | | | | | |
Basic | | | $ | 0.56 | | | $ | (0.51) | | | $ | (0.55) | |
Diluted | | | $ | 0.50 | | | $ | (0.51) | | | $ | (0.55) | |
Weighted-average common shares outstanding | | | | | | | |
Basic | | | 285,056,606 | | 289,166,486 | | 294,327,532 |
Diluted | | | 314,827,255 | | 289,166,486 | | 294,327,532 |
(1) Exclusive of depreciation, amortization, and impairment
AbCellera Biologics Inc.
Consolidated Balance Sheets
(All figures in U.S. dollars. Amounts are expressed in thousands except share data.)
| | | | | | | | | |
| December 31, 2023 | | December 31, 2024 |
Assets | | | |
Current assets: | | | |
Cash and cash equivalents | $ | 133,320 | | | $ | 156,325 | |
Marketable securities | 627,265 | | | 469,289 | |
Total cash, cash equivalents, and marketable securities | 760,585 | | | 625,614 | |
Accounts and accrued receivable | 30,590 | | | 33,616 | |
Restricted cash | 25,000 | | | 25,000 | |
Other current assets | 55,810 | | | 67,140 | |
Total current assets | 871,985 | | | 751,370 | |
Long-term assets: | | | |
Property and equipment, net | 287,696 | | | 340,429 | |
Intangible assets, net | 120,425 | | | 42,113 | |
Goodwill | 47,806 | | | 47,806 | |
Investments in equity accounted investees | 65,938 | | | 82,297 | |
Other long-term assets | 94,244 | | | 96,538 | |
Total long-term assets | 616,109 | | | 609,183 | |
Total assets | $ | 1,488,094 | | | $ | 1,360,553 | |
Liabilities and shareholders' equity | | | |
Current liabilities: | | | |
Accounts payable and other current liabilities | $ | 49,580 | | | $ | 55,004 | |
Contingent consideration payable | 50,475 | | | 8,087 | |
| | | |
| | | |
Deferred revenue | 18,958 | | | 13,521 | |
Total current liabilities | 119,013 | | | 76,612 | |
Long-term liabilities: | | | |
Operating lease liability | 71,222 | | | 60,743 | |
Deferred revenue | 8,195 | | | 5,700 | |
Deferred government contributions | 95,915 | | | 149,893 | |
Contingent consideration payable | 4,913 | | | — | |
Deferred tax liability | 30,612 | | | 10,052 | |
Other long-term liabilities | 5,906 | | | 1,469 | |
Total long-term liabilities | 216,763 | | | 227,857 | |
Total liabilities | 335,776 | | | 304,469 | |
Commitments and contingencies | | | |
Shareholders' equity: | | | |
Common shares: no par value, unlimited authorized shares at December 31, 2023 and December 31, 2024: 290,824,970 and 295,757,002 shares issued and outstanding at December 31, 2023 and December 31, 2024, respectively | 753,199 | | | 777,171 | |
Additional paid-in capital | 121,052 | | | 166,361 | |
Accumulated other comprehensive loss | (1,720) | | | (4,378) | |
Accumulated earnings | 279,787 | | | 116,930 | |
Total shareholders' equity | 1,152,318 | | | 1,056,084 | |
Total liabilities and shareholders' equity | $ | 1,488,094 | | | $ | 1,360,553 | |
AbCellera Biologics Inc.
Consolidated Statement of Cash Flows
(Expressed in thousands of U.S. dollars.)
| | | | | | | | | | | | | | | | | | |
| | December 31, 2022 | | December 31, 2023 | | December 31, 2024 |
Cash flows from operating activities: | | | | | | |
Net earnings (loss) | | $ | 158,519 | | | $ | (146,398) | | | $ | (162,857) | |
Cash flows from operating activities: | | | | | | |
Depreciation of property and equipment | | 8,953 | | | 12,758 | | | 12,537 | |
Amortization and impairment of intangible assets | | 18,890 | | | 11,637 | | | 78,312 | |
Amortization of operating lease right-of-use assets | | 5,259 | | | 6,499 | | | 6,149 | |
Stock-based compensation | | 49,481 | | | 64,183 | | | 67,581 | |
Fair value (gain) loss on contingent consideration and investments | | 3,091 | | | (8,018) | | | (64,727) | |
Other | | 3,342 | | | 2,237 | | | (19,708) | |
Changes in operating assets and liabilities: | | | | | | |
Research fee and grant receivable | | (22,715) | | | (45,933) | | | (75,119) | |
Accrued royalties receivable | | 129,171 | | | 9,273 | | | — | |
Income taxes (payable) receivable | | (88,609) | | | 30,464 | | | 6,651 | |
Accounts payable and accrued liabilities | | (2,094) | | | (15,104) | | | 10,635 | |
Deferred revenue | | 6,183 | | | (13,976) | | | (7,931) | |
Deferred grant income | | 9,264 | | | 39,521 | | | 33,967 | |
Other assets | | (1,375) | | | 8,980 | | | 5,954 | |
Net cash provided by (used in) operating activities | | 277,360 | | | (43,877) | | | (108,556) | |
Cash flows from investing activities: | | | | | | |
Purchases of property and equipment | | (70,660) | | | (76,947) | | | (78,396) | |
Purchase of intangible assets | | (2,000) | | | (560) | | | — | |
Purchase of marketable securities | | (763,982) | | | (1,021,510) | | | (765,086) | |
Proceeds from marketable securities | | 510,631 | | | 910,937 | | | 937,882 | |
Receipt of grant funding | | 16,434 | | | 25,311 | | | 35,708 | |
Investment in and loans to equity accounted investees | | (25,679) | | | (13,690) | | | (19,626) | |
Long-term investments and other assets | | (17,369) | | | (44,649) | | | 10,927 | |
Net cash provided by (used in) investing activities | | (352,625) | | | (221,108) | | | 121,409 | |
Cash flows from financing activities: | | | | | | |
Payment of liability for in-licensing agreement and other | | (4,383) | | | (1,234) | | | (729) | |
Proceeds from long-term liabilities and exercise of stock options | | 2,755 | | | 11,590 | | | 13,498 | |
Net cash provided by (used in) financing activities | | (1,628) | | | 10,356 | | | 12,769 | |
Effect of exchange rate changes on cash and cash equivalents | | (9,599) | | | 589 | | | (2,617) | |
Increase (decrease) in cash and cash equivalents | | (86,492) | | | (254,040) | | | 23,005 | |
Cash and cash equivalents and restricted cash, beginning of period | | 501,142 | | | 414,650 | | | 160,610 | |
Cash and cash equivalents and restricted cash, end of period | | $ | 414,650 | | | $ | 160,610 | | | $ | 183,615 | |
Restricted cash included in other assets | | 3,115 | | | 2,290 | | | 2,290 | |
Total cash, cash equivalents, and restricted cash shown on the balance sheet | | $ | 411,535 | | | $ | 158,320 | | | $ | 181,325 | |
Supplemental disclosure of non-cash investing and financing activities | | | | | | |
Property and equipment in accounts payable | | 5,868 | | | 13,625 | | | 12,767 | |
Right-of-use assets obtained in exchange for operating lease obligation | | 50,694 | | | 1,199 | | | 1,898 | |
CO PY RI GH T © A BC EL LE RA FEBRUARY 27, 2025 FULL YEAR 2024 BUSINESS UPDATE
These statements involve risks, uncertainties and other factors that may cause actual results, levels of activity, performance, or achievements to be materially different from the information expressed or implied by these forward-looking statements. These risks, uncertainties and other factors are described under "Risk Factors," "Management's Discussion and Analysis of Financial Condition and Results of Operations" and elsewhere in the documents we file with the Securities and Exchange Commission from time to time. We caution you that forward-looking statements are based on a combination of facts and factors currently known by us and our projections of the future, about which we cannot be certain. As a result, the forward-looking statements may not prove to be accurate. The forward-looking statements in this presentation represent our views as of the date hereof. We undertake no obligation to update any forward-looking statements for any reason, except as required by law. DISCLAIMER This presentation contains forward-looking statements, including statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. The forward-looking statements are based on management’s beliefs and assumptions and on information currently available to management. All statements contained in this presentation other than statements of historical fact are forward-looking statements, including statements regarding our ability to develop, commercialize and achieve market acceptance of our current and planned products and services, our research and development efforts, and other matters regarding our business strategies, use of capital, results of operations and financial position, and plans and objectives for future operations. In some cases, you can identify forward-looking statements by the words “may,” “will,” “could,” “would,” “should,” “expect,” “intend,” “plan,” “anticipate,” “believe,” “estimate,” “predict,” “project,” “potential,” “continue,” “ongoing” or the negative of these terms or other comparable terminology, although not all forward-looking statements contain these words. 2 CO PY RI GH T © A BC EL LE RA Fu ll Y ea r 2 02 4 Bu si ne ss U pd at e
3 CO PY RI GH T © A BC EL LE RA Fu ll Y ea r 2 02 4 Bu si ne ss U pd at e FULL YEAR 2024 RECAP Transitioning into a clinical-stage biotech. Completing Investments in Our Engine Building Internal Pipeline & Programs ● Put first 2 programs on track for Clinical Trial Application (CTA) submissions in Q2 2025 ● Advanced discovery pipeline of antibody drug programs with first-in-class or best-in-class potential ● Moved into new HQ ● Built Phase 1 clinical manufacturing and operations capabilities for launch in 2025 Reducing New Discovery Partnership Activity ● 2 new partnerships ● 1 partnership expansion in available liquidity to execute on our strategy~$840M
4 CO PY RI GH T © A BC EL LE RA Fu ll Y ea r 2 02 4 Bu si ne ss U pd at e Use our competitive advantage in antibody drug creation to build a pipeline of differentiated assets. STRATEGY
5 CO PY RI GH T © A BC EL LE RA Fu ll Y ea r 2 02 4 Bu si ne ss U pd at e Is there an opportunity for differentiation? Is there a clear development path? Is there a commercial opportunity with an unmet medical need? Do we like the science? Our platform supports multiple modalities including IgGs, ADCs and bispecifics. Our strategy is to look broadly for programs that have the highest potential ROI, without constraint by indication. We manage our portfolio and assess opportunities by asking the following questions: Pursue high-value opportunities across multiple indications and modalities. INTERNAL PIPELINE & PROGRAMS
6 CO PY RI GH T © A BC EL LE RA ● Potential first-in-class antibody in area of metabolic and endocrine conditions ● Expect differentiated safety profile vs small molecules ● Convenience and compliance with subcutaneous dosing schedule Fu ll Y ea r 2 02 4 Bu si ne ss U pd at e ABCL635 Undisclosed Science DifferentiationCommercial Opp Development Path ● Pathway validated with small molecules ● High unmet need in large target population ● >$2B estimated market ● Clear clinical development path ● CTA* filing anticipated in Q2 2025 with safety and early efficacy data readout in 2026 * Clinical Trial Applications (CTAs) = Canadian equivalent to an Investigational New Drug (IND) submission INTERNAL PIPELINE & PROGRAMS
7 CO PY RI GH T © A BC EL LE RA Fu ll Y ea r 2 02 4 Bu si ne ss U pd at e ● OX40L mechanism of action established in atopic dermatitis with a favourable safety profile ● High potential across multiple immunology and inflammation (I&I) indications (asthma, alopecia, HS, celiac etc.) ● Attractive pathway for development of combinations in I&I * Cantor Fitzgerald Estimate, September, 2024 ● Competitive space with two late stage programs targeting OX40L (amlitelimab) and OX40 (rocatilimab) ● ABCL575 expected to support Q12W or longer dosing schedule ● Atopic dermatitis is an $11B+* market, growing at over 25% ● Need for alternatives beyond IL-13 and IL-4/13 classes in both 1st line and 2nd line (more than 20%** of dupilumab patients discontinue) ● Potential of OX40L class across multiple indications is being evaluated ● Well-established clinical development path ● CTA*** filing anticipated in Q2 2025 with safety and PK in 2026 ** Spekhorst et al. JAMA Dermatol. 2022; 158(9): 1048 *** Clinical Trial Applications (CTAs) = Canadian equivalent to an Investigational New Drug (IND) submission ABCL575 OX40L Antagonist INTERNAL PIPELINE & PROGRAMS Science DifferentiationCommercial Opp Development Path
8 CO PY RI GH T © A BC EL LE RA MOLECULE TARGET THERAPEUTIC AREA STAGE ABCL635 Undisclosed GPCR or ion channel Metabolic & Endocrine Conditions ABCL575 OX40L Immunology & Inflammation Fu ll Y ea r 2 02 4 Bu si ne ss U pd at e In 2025 we intend to submit CTAs* for our first 2 programs. * Clinical Trial Applications (CTAs) = Canadian equivalent to an Investigational New Drug (IND) submission CTA / IND-Enabling 2025 Q1 In progress CTA Submission 2025 Q2 Anticipated Phase I Readout 2026 Anticipated CTA / IND-Enabling 2025 Q1 In progress CTA Submission 2025 Q2 Anticipated Phase I Readout 2026 Anticipated 20+ discovery programs in the pipeline INTERNAL PIPELINE & PROGRAMS
9 CO PY RI GH T © A BC EL LE RA Fu ll Y ea r 2 02 4 Bu si ne ss U pd at e In order to focus on our pipeline, we decreased new discovery partnership activity. new partnerships 2 AbbVie partnership expansion 1 Entered into first significant TCE partnership agreement based on T-Cell Engager platform: Entered into 3 partnership agreements in the first half of 2024: PARTNERING PORTFOLIO 2024 Partnering Activity T-Cell Engager Platform Activity partnership expansion 1
10 CO PY RI GH T © A BC EL LE RA Fu ll Y ea r 2 02 4 Bu si ne ss U pd at e Enter the clinic and initiate clinical manufacturing activities at new facility. ABCL635 Phase 1 clinical trials initiated in 2025 ABCL575 Phase 1 clinical trials initiated in 2025 Complete platform investments by the first half of the year Initiate activities at the new clinical manufacturing facility Nominate additional development candidate(s) for CTA-enabling studies 2025 PRIORITIES
11 CO PY RI GH T © A BC EL LE RA Fu ll Y ea r 2 02 4 Bu si ne ss U pd at e We expect a number of key milestones in the next 18-24 months. CTA submissions anticipated in Q2 2025. If successful, initiation of Phase 1 clinical trials to follow: ● ABCL635 ● ABCL575 20+ internal programs in the pipeline: ● Expect steady flow of readouts on potentially first-in-class therapeutic antibodies Anticipate readout of Phase 1 clinical data: ● ABCL635 ● ABCL575 First 2 clinical data readouts in 2026 First 2 CTAs* & start of clinical trials in 2025 Intention to submit 1-3 INDs per year over next 5 years POTENTIAL MILESTONES * Clinical Trial Applications (CTAs) = Canadian equivalent to an Investigational New Drug (IND) submission
12 CO PY RI GH T © A BC EL LE RA Fu ll Y ea r 20 24 B us in es s U pd at e FULL YEAR 2024 FINANCIALS UPDATE
13 CO PY RI GH T © A BC EL LE RA Fu ll Y ea r 2 02 4 Bu si ne ss U pd at e in total cash, cash equivalents, & marketable securities cumulative partner-initiated program starts with downstreams internal programs advanced into IND/CTA-enabling studies ~$650M 96 2 molecules in the clinic16 in available liquidity to execute on our strategy~$840M Continued progress on key business metrics and a strong cash position.
14 CO PY RI GH T © A BC EL LE RA Fu ll Y ea r 2 02 4 Bu si ne ss U pd at e PARTNER-INITIATED PROGRAM STARTS WITH DOWNSTREAMS Cumulative # of MOLECULES IN THE CLINIC Cumulative # of Note: Showing year-end figures. Historical results are not necessarily indicative of future results. Notable Updates on Molecule This Quarter’s Update ABD-147 Advanced into Phase 1 trial Undisclosed (Trianni license) New, in Phase 1/2 trial GIGA-564 (Trianni license) New, in Phase 1 trial Continuing portfolio growth. MOLECULES IN THE CLINIC
15 CO PY RI GH T © A BC EL LE RA Fu ll Y ea r 2 02 4 Bu si ne ss U pd at e Partner-initiated programs continue to progress towards the clinic. PARTNER-INITIATED PROGRAMS WITH DOWNSTREAM PARTICIPATION*Cumulative # of *Excludes AbCellera-initiated and Trianni-license program. As of Dec 31, 2024. Historical results are not necessarily indicative of future results. 96 6 76 39 14 37 42 5 4 Understood to be Progressing In Progress AbCellera Leading or Co-Leading Work Partner Leading Work AbCellera Started Transferred to Partner Clinical Development Preclinical Development Discovery Not Expected to Progress Not Expected to Progress
16 CO PY RI GH T © A BC EL LE RA Large diversified exposure to next-gen antibody therapies. *As of December 31, 2024 AbCellera-Initiated Programs* started across these therapeutic areas27 100% human health n = 27 Partner-Initiated Programs with Downstream Participation* started are diversified across these therapeutic areas 96 91% human health: target antigen known n = 87 9% animal health n = 9 21% neurology 6% infectious disease 5% ophthal- mology 4% other 17% immunology & inflammation 47% oncology 30% oncology & immunology T-cell engagers 56% undisclosed GPCRs & ion channels n = 8 n = 15 infectious disease pandemic response 4%10% undisclosed other n = 3 n = 1 Fu ll Y ea r 2 02 4 Bu si ne ss U pd at e
17 CO PY RI GH T © A BC EL LE RA Fu ll Y ea r 2 02 4 Bu si ne ss U pd at e Operating expenses reflect investments, predominantly in R&D; partly offset by $29M in revenue. Operating Expenses USDRevenue USD 20242023 $175.7M $167.3M -$8.4M 20242023 $14.2M $12.8M -$1.4M 20242023 $61.0M $72.7M +$11.7M RESEARCH & DEVELOPMENT SALES & MARKETING GENERAL & ADMINLICENSING RESEARCH FEES MILESTONES 2024 $26.3M 2023 $38.0M $28.8M $1.5M $1.0M$35.6M Milestones Licensin g Research fees
18 CO PY RI GH T © A BC EL LE RA Fu ll Y ea r 2 02 4 Bu si ne ss U pd at e Net loss of $163M; equivalent to ($0.55) per share (basic & diluted). Earnings USD NET EARNINGS EARNINGS PER SHARE: BASIC AND DILUTED 2023 2024 ($146.4M) ($162.9M) Post-production ❑ Move “Q” labels down
19 CO PY RI GH T © A BC EL LE RA Fu ll Y ea r 2 02 4 Bu si ne ss U pd at e Approximately $653M in total cash, equivalents, and marketable securities. Cash Flows USD * Restricted cash (including restricted cash in other assets) ($51M) Other INVESTING FINANCING FX $469M Marketable Securities $156M Cash & Equivalents $27M* $627M Marketable Securities $173M Marketable Securities (net) OPERATINGDec 31, 2023 $27M* $133M Cash & Equivalents $788M ($109M) $121M $13M ($3M) $653M Dec 31, 2024
20 CO PY RI GH T © A BC EL LE RA Fu ll Y ea r 2 02 4 Bu si ne ss U pd at e THANK YOU
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AbCellera Biologics (NASDAQ:ABCL)
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