As filed with the Securities and Exchange Commission
on December 4, 2024
Registration No. 333-
UNITED STATES
SECURITIES AND
EXCHANGE COMMISSION
Washington, D.C. 20549
Form S-3
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
AVENUE THERAPEUTICS, INC.
(Exact name of registrant as specified in its charter)
Delaware
(State or other jurisdiction of
incorporation or organization) |
47-4113275
(I.R.S. Employer
Identification No.) |
1111 Kane Concourse, Suite 301
Bay Harbor Islands, Florida 33154
(781) 652-4500
(Address, including zip code, and telephone number,
including
area code, of registrant’s principal executive offices)
Alexandra MacLean, M.D.
Chief Executive Officer
1111 Kane Concourse, Suite 301
Bay Harbor Islands, Florida 33154
(781) 652-4500
(Name, address, including zip code, and telephone
number, including area code, of agent for service)
With a copy to:
Rakesh Gopalan
David S. Wolpa
Troutman Pepper Hamilton Sanders LLP
301 S. College Street, 34th Floor
Charlotte, NC 28202
(704) 998-4050
Approximate date of commencement of proposed sale to the public:
From time to time after the effective date of this registration statement.
If
the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please
check the following box: ¨
If
any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415
under the Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, check
the following box: x
If
this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act,
please check the following box and list the Securities Act registration statement number of the earlier effective registration statement
for the same offering. ¨
If
this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box
and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ¨
If
this Form is a registration statement pursuant to General Instruction I.D. or a post-effective amendment thereto that shall become
effective upon filing with the Commission pursuant to Rule 462(e) under the Securities Act, check the following box. ¨
If
this Form is a post-effective amendment to a registration statement filed pursuant to General Instruction I.D. filed to register
additional securities or additional classes of securities pursuant to Rule 413(b) under the Securities Act, check the following
box. ¨
Indicate by check mark whether the registrant is
a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company.
See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,”
and “emerging growth company” in Rule 12b-2 of the Exchange Act.
Large
accelerated filer ¨ |
Accelerated
filer ¨ |
Non-accelerated
filer x |
Smaller
reporting company x |
Emerging
growth company ¨ |
If
an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying
with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ¨
The Registrant hereby amends this registration
statement on such date or dates as may be necessary to delay its effective date until the Registrant shall file a further amendment that
specifically states that this registration statement shall thereafter become effective in accordance with Section 8(a) of the
Securities Act or until the registration statement shall become effective on such date as the Securities and Exchange Commission, acting
pursuant to said Section 8(a), may determine.
EXPLANATORY NOTE
This registration statement
is a replacement registration statement being filed pursuant to Rule 415(a)(6) under the Securities Act of 1933, as amended
(the “Securities Act”), with respect to securities that remain unsold under the Registration Statement on Form S-3 (File
No. 333-261520), originally filed on December 7, 2021, and declared effective on December 10, 2021 (the “Prior Registration
Statement”). Pursuant to Rule 415(a)(5)(ii) under the Securities Act, by filing this registration statement on Form S-3
(the “Registration Statement”), the Company may issue and sell securities covered by the Prior Registration Statement until
the earlier of (i) the effective date of this Registration Statement and (ii) June 8, 2025, which is 180 days after the
third-year anniversary of the effective date of the Prior Registration Statement.
The information in this prospectus
is not complete and may be changed. We may not sell these securities or accept an offer to buy these securities until the registration
statement filed with the Securities and Exchange Commission is effective. This prospectus is not an offer to sell these securities, and
it is not soliciting offers to buy these securities in any jurisdiction where such offer or sale is not permitted.
SUBJECT TO COMPLETION, DATED
DECEMBER 4, 2024
PRELIMINARY PROSPECTUS
$35,000,000
Common Stock
Preferred Stock
Warrants
Debt Securities
Units
The following are types of
securities that we may offer, issue and sell from time to time, together or separately:
| · | shares of our common stock; |
| · | shares of our preferred stock; |
| · | warrants; |
| · | debt securities; and |
| · | units consisting of any combination of our common stock, preferred stock, warrants or debt securities. |
We may offer these securities
in amounts, at prices, and on terms determined at the time of offering, up to an aggregate amount of $35,000,000. We may sell these securities
directly to you through agents we select or through underwriters and dealers we select. If we use agents, underwriters or dealers to sell
these securities, we will name them and describe their compensation in a prospectus supplement. See “Plan of Distribution.”
You should read this prospectus and any prospectus supplement carefully before you invest.
This prospectus provides a
general description of the securities we may offer. Each time we sell securities, we will provide specific terms of the securities offered
in a supplement to this prospectus. The prospectus supplement may also add, update or change information contained in this prospectus.
You should read this prospectus and the applicable prospectus supplement carefully, together with additional information described under
the heading “Where You Can Find More Information,” before you invest in any securities. This prospectus may not be
used to consummate a sale of securities unless accompanied by the applicable prospectus supplement.
Our common stock is traded
on the Nasdaq Capital Market under the symbol “ATXI.” On December 2, 2024, the per share closing price of our common
stock as reported on the Nasdaq Capital Market was $1.94 per share.
The aggregate market value
of our outstanding common stock held by non-affiliates is approximately $4,707,680, which was calculated in accordance with General Instruction
I.B.6 of Form S-3, based on 2,053,923 shares of common stock outstanding as of December 3, 2024, of which 185,796 are held by
non-affiliates, at the closing share price of $2.52 on October 28, 2024, which was the highest closing price of our common stock
reported on the Nasdaq Capital Market within the last 60 days prior to the date of this filing.
In this prospectus we are
offering up to $35,000,000 of securities; however, pursuant to General Instruction I.B.6 of Form S-3, in no event will we sell the
securities described in this prospectus in a public primary offering with a value exceeding more than one-third of the aggregate market
value of our common stock held by non-affiliates in the twelve month period prior to the date of the sale of any such securities, so long
as the aggregate market value of our outstanding common stock held by non-affiliates remains below $75.0 million.
Investing in our securities
involves a high degree of risk. You should carefully review the risks and uncertainties described under the heading “Risk Factors”
contained in the applicable prospectus supplement and any related free writing prospectus, and under similar headings in the other documents
that are incorporated by reference into this prospectus as described on page 4 of this prospectus.
Neither the Securities
and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus
is truthful or complete. Any representation to the contrary is a criminal offense.
The date of this prospectus is ,
2024.
TABLE OF CONTENTS
ABOUT THIS PROSPECTUS
In this prospectus, unless
the context suggests otherwise, references to “Avenue Therapeutics,” “Avenue,” the “Company,” “we,”
“us” and “our” refer to Avenue Therapeutics, Inc. and its consolidated subsidiary.
This prospectus is part of
a “shelf” registration statement that we filed with the Securities and Exchange Commission. By using a shelf registration
statement, we may sell our securities, as described in this prospectus, from time to time in one or more offerings. This prospectus provides
you with a general description of the securities offered by us. Each time we sell securities, we will provide a prospectus supplement
to this prospectus that contains specific information about the terms of such offering. The prospectus or prospectus supplement may also
add, update or change information contained in this prospectus.
You should rely only on the
information contained or incorporated by reference in this prospectus and any prospectus supplement or issuer free writing prospectus
relating to a particular offering. No person has been authorized to give any information or make any representations in connection with
this offering other than those contained or incorporated by reference in this prospectus, any accompanying prospectus supplement and any
related issuer free writing prospectus in connection with the offering described herein and therein, and, if given or made, such information
or representations must not be relied upon as having been authorized by us. Neither this prospectus nor any prospectus supplement nor
any related issuer free writing prospectus shall constitute an offer to sell or a solicitation of an offer to buy offered securities in
any jurisdiction in which it is unlawful for such person to make such an offering or solicitation. This prospectus does not contain all
of the information included in the registration statement. For a more complete understanding of the offering of the securities, you should
refer to the registration statement, including its exhibits. You should read the entire prospectus and any prospectus supplement and any
related issuer free writing prospectus, as well as the documents incorporated by reference into this prospectus or any prospectus supplement
or any related issuer free writing prospectus, before making an investment decision. Neither the delivery of this prospectus or any prospectus
supplement or any issuer free writing prospectus nor any sale made hereunder shall under any circumstances imply that the information
contained or incorporated by reference herein or in any prospectus supplement or issuer free writing prospectus is correct as of any date
subsequent to the date hereof or of such prospectus supplement or issuer free writing prospectus, as applicable.
This prospectus may not be used to consummate
a sale of securities unless it is accompanied by a prospectus supplement.
PROSPECTUS
SUMMARY
This summary highlights
selected information from this prospectus and does not contain all of the information that may be important to you in making an investment
decision. This summary is qualified in its entirety by the more detailed information included elsewhere in this prospectus and/or incorporated
by reference herein. Before making your investment decision with respect to our securities, you should carefully read this entire prospectus
and any prospectus supplement that we have authorized for use in connection with this offering, including the information in our filings
with the Securities and Exchange Commission (“SEC”) incorporated by reference into this prospectus.
Our Business
Overview and Product Candidate Development
We are a specialty pharmaceutical
company focused on the development and commercialization of therapies for the treatment of neurologic diseases. Our product candidates
include AJ201 for the treatment of spinal and bulbar muscular atrophy (“SBMA”, also known as Kennedy’s Disease), intravenous
tramadol (“IV tramadol”) for the treatment of post-operative acute pain, and BAER-101 for the treatment of epilepsy and panic
disorders.
AJ201
In February 2023, we
announced that we entered into a license agreement (the “AnnJi License Agreement”) with AnnJi Pharmaceutical Co., Ltd.
(“AnnJi”) whereby the Company obtained an exclusive license from AnnJi to intellectual property rights pertaining to the molecule
known as JM17, which activates Nrf1 and Nrf2, enhances androgen receptor degradation and underlies AJ201, a clinical product candidate
currently in a Phase 1b/2a clinical trial in the United States (“U.S.”) for the treatment of SBMA.
Under the AnnJi License Agreement,
in exchange for exclusive rights to the intellectual property underlying the AJ201 product candidate, the Company paid an initial
cash license fee of $3.0 million. The Company issued shares of its common stock and is obligated to make additional payments over the
course of the AnnJi License Agreement including reimbursement payments of up to $10.8 million in connection with the product’s Phase
1b/2a clinical trial.
The license provided under
the AnnJi License Agreement is exclusive as to all oral forms of AJ201 for use in all indications (other than androgenetic alopecia and
Alzheimer’s disease) in the United States, Canada, the European Union, the United Kingdom and Israel. The AnnJi License Agreement
also contains customary representations and warranties and provisions related to confidentiality, diligence, indemnification and intellectual
property protection. The Company is initially obligated to obtain both clinical and commercial supply of AJ201 exclusively through
AnnJi.
The 12-week, multicenter,
randomized, double-blind trial enrolled 25 patients, randomly assigned to AJ201 (600mg/day) or placebo. The primary endpoint of the
study is to assess safety and tolerability of AJ201 in subjects with clinically and genetically defined SBMA. Secondary endpoints include
pharmacodynamic data measuring change from baseline in mutant androgen receptor protein levels in skeletal muscle and changes in the fat
and muscle composition as seen on MRI scans. Further details on the study can be found using the ClinicalTrials.gov identifier NCT05517603.
Information on clinicaltrials.gov does not constitute part of this prospectus.
In May 2024, we announced
last patient last visit in the Phase 1b/2a trial and anticipate top-line data readout around year-end 2024.
IV Tramadol
We participated in a Type
C meeting with the U.S. Food and Drug Administration (the “FDA”) in March 2023 to discuss a proposed study protocol to
assess the risk of respiratory depression related to opioid stacking on IV tramadol relative to an approved opioid analgesic. We announced
in April 2023 that we received official meeting minutes from the Type C meeting with the FDA. The Type C meeting minutes indicate
that we are in agreement with the FDA on a majority of the proposed protocol items and are in active discussion about remaining open items.
The minutes indicate that the FDA also agrees that a successful study will support the submission of a complete response to the second
Complete Response Letter for IV tramadol pending final agreement on a statistical analysis plan and a full review of the submitted data
in the complete response as well as concurrence from the Division of Anesthesia,
Analgesia, and Addiction Products.
In January 2024, we announced
that we reached final agreement with the FDA on the Phase 3 safety study protocol and statistical analysis approach, including the primary
endpoint. The final non-inferiority study is designed to assess the risk of opioid-induced respiratory depression related to opioid stacking
on IV tramadol compared to IV morphine. The study will randomize approximately 300 post bunionectomy patients to IV tramadol or IV morphine
for pain relief administered during a 48-hour post-operative period. Of note, this study design was used in the first of two Phase 3 trials. In
a Phase 3 safety study to be conducted, patients will have access to IV hydromorphone, a Schedule II opioid, for rescue of breakthrough
pain. The primary endpoint is a composite of elements indicative of respiratory depression.
We plan to initiate the study
as soon as possible, subject to having the necessary financing.
BAER-101
(novel α2/3–subtype-selective GABA A PAM)
Baergic is a clinical-stage
pharmaceutical company founded in December 2019 that focuses on the development of pharmaceutical products for the treatment of neurologic
disorders. Baergic was acquired by the Company pursuant to a stock contribution agreement (the “Contribution Agreement”) with
Fortress, in order to strategically align with Avenue’s goals of building a rare and neurologic pipeline. Baergic’s pipeline
currently consists of a single compound, BAER-101, a novel α2/3–subtype-selective GABA A positive allosteric modulator. BAER-101
(formerly known as AZD7325) was originally developed by AstraZeneca and has an established safety profile in early clinical trials including
over 700 patients.
In August 2023, we reported
preclinical data for BAER-101 from an in vivo evaluation in SynapCell’s Genetic Absence Epilepsy Rate from the Strasbourg (“GAERS”)
model of absence epilepsy. The GAERS model mimics behavioral, electrophysiological and pharmacological features of human absence seizures
and has shown to be an early informative indicator of efficacy in anti-seizure drug development. In the model, BAER-101 demonstrated full
suppression of seizure activity with a minimal effective dose of 0.3 mg/kg administered orally. The data were subsequently presented at
the American Epilepsy Society (“AES”) 2023 Annual Meeting in December 2023 and at the American Society for Experimental
Neurotherapeutics (“ASENT”) 2024 Annual Meeting in March 2024. The data were also published in Drug Development
Research in February 2024.
Under the Contribution Agreement,
Fortress also agreed to assign to us certain intercompany agreements existing between Fortress and Baergic, including a Founders Agreement
and Management Services Agreement.
Implications of Being a Smaller Reporting Company
We are a “smaller reporting
company,” meaning that either (i) the market value of our shares held by non-affiliates is less than $250 million or (ii) the
market value of our shares held by non-affiliates is less than $700 million and our annual revenue was less than $100 million during the
most recently completed fiscal year. We may continue to be a smaller reporting company if either (i) the market value of our shares
held by non-affiliates is less than $250 million or (ii) our annual revenue was less than $100 million during the most recently completed
fiscal year and the market value of our shares held by non-affiliates is less than $700 million. As a smaller reporting company, we chose
to present only the two most recent fiscal years of audited financial statements in the Company’s Annual Report on Form 10-K,
which was filed with the SEC on March 18, 2024, have reduced disclosure obligations regarding executive compensation and certain
other matters, and smaller reporting companies are permitted to delay adoption of certain recent accounting.
Corporate Information
We
are a majority-controlled subsidiary of Fortress. Baergic is our sole subsidiary.
Avenue Therapeutics, Inc.
was incorporated in Delaware on February 9, 2015. Our executive offices are located at 1111 Kane Concourse, Suite 301, Bay Harbor
Islands Florida, 33154. Our telephone number is (781) 652-4500, and our email address is info@avenuetx.com. Information on our website,
or any other website, is not incorporated by reference in this prospectus. We have included our website address in this prospectus solely
as an inactive textual reference.
RISK FACTORS
An investment in our securities
involves a high degree of risk. The prospectus supplement applicable to each offering of our securities will contain a discussion of the
risks applicable to an investment in our securities. Prior to making a decision about investing in our securities, you should carefully
consider the specific factors discussed under the heading “Risk Factors” in the applicable prospectus supplement, together
with all of the other information contained or incorporated by reference in the prospectus supplement or appearing or incorporated by
reference in this prospectus. Each of the referenced risks and uncertainties could adversely affect our business, operating results and
financial condition, as well as adversely affect the value of an investment in our securities.
FORWARD-LOOKING STATEMENTS
This prospectus contains predictive
or “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. All statements
other than statements of current or historical fact contained in this prospectus, including statements that express our intentions, plans,
objectives, beliefs, expectations, strategies, predictions or any other statements relating to our future activities or other future events
or conditions are forward-looking statements. The words “anticipate,” “believe,” “continue,” “could,”
“estimate,” “expect,” “intend,” “may,” “plan,” “predict,” “project,”
“will,” “should,” “would” and similar expressions, as they relate to us, are intended to identify
forward-looking statements.
These statements are based
on current expectations, estimates and projections made by management about our business, our industry and other conditions affecting
our financial condition, results of operations or business prospects. These statements are not guarantees of future performance and involve
risks, uncertainties and assumptions that are difficult to predict. Therefore, actual outcomes and results may differ materially from
what is expressed or forecasted in, or implied by, the forward-looking statements due to numerous risks and uncertainties. Factors that
could cause such outcomes and results to differ include, but are not limited to, risks and uncertainties arising from:
| · | the fact that we currently have no drug products for sale and that our success is dependent on our product
candidates receiving regulatory approval and being successfully commercialized; |
| · | the possibility that serious adverse or unacceptable side effects are identified during the development
of our current or future product candidates, such that we would need to abandon or limit development of some of our product candidates; |
| · | our ability to successfully develop, partner, or commercialize any of our current or future product candidates
including AJ201, IV tramadol, and BAER-101; |
| · | the substantial doubt raised about our ability to continue as a going concern, which may hinder our ability
to obtain future financing; |
| · | the significant losses we have incurred since inception and our expectation that we will continue to incur
losses for the foreseeable future; |
| · | our need for substantial additional funding, which may not be available to us on acceptable terms, or
at all, which unavailability could force us to delay, reduce or eliminate our product development programs or commercialization efforts; |
| · | our reliance on third parties for several aspects of our operations; |
| · | our reliance on clinical data and results obtained by third parties that could ultimately prove to be
inaccurate, unreliable, or unacceptable to regulatory authorities; |
| · | the possibility that we may not receive regulatory approval for any or all of our product candidates,
or that such approval may be significantly delayed due to scientific or regulatory reasons; |
| · | the fact that even if one or more of our product candidates receives regulatory approval, they will remain
subject to substantial regulatory scrutiny; |
| · | the effects of current and future laws and regulations relating to fraud and abuse, false claims, transparency,
health information privacy and security, and other healthcare laws and regulations; |
| · | the effects of competition for our product candidates and the potential for new products to emerge that
provide different or better therapeutic alternatives for our targeted indications; |
| · | the possibility that the government or third-party payors fail to provide adequate coverage and payment
rates for our product candidates or any future products; |
| · | our ability to establish sales and marketing capabilities or to enter into agreements with third parties
to market and sell our product candidates; |
| · | our exposure to potential product liability claims; |
| · | related to the protection of our intellectual property and our potential inability to maintain sufficient
patent protection for our technology and products; |
| · | our ability to maintain compliance with the obligations under our intellectual property licenses and funding
arrangements with third parties, without which licenses and arrangements we could lose rights that are important to our business; |
| · | the fact that Fortress Biotech, Inc. ("Fortress") controls a majority of the voting
power of our outstanding capital stock and has rights to receive significant share grants annually; |
| · | our failure to satisfy applicable listing standards
of the Nasdaq Capital Market resulting in a potential delisting of our common stock; and |
| · | and the risks described under the section titled “Risk Factors” in our Annual
Report on Form 10-K for the year ended December 31, 2023. |
Any forward-looking statements
speak only as of the date on which they are made, and we undertake no obligation to publicly update or revise any forward-looking statements
to reflect events or circumstances that may arise after the date of this prospectus, except as required by applicable law. Investors should
evaluate any statements made by us in light of these important factors. We qualify all of our forward-looking statements by these cautionary
statements. In addition, with respect to all of our forward-looking statements, we claim the protection of the safe harbor for forward-looking
statements contained in the Private Securities Litigation Reform Act of 1995.
USE OF PROCEEDS
Unless otherwise indicated
in the prospectus supplement, the net proceeds from the sale of securities offered by this prospectus will be used for general corporate
purposes and working capital requirements, which may include, among other things, the advancement of our product candidates to obtain
regulatory approval from the FDA, and in the event of FDA approval of our product candidates, towards the milestone payments due to our
licensor and supplier upon FDA approval of our product candidates. We have not determined the amounts we plan to spend on the areas listed
above or the timing of these expenditures, and we have no current plans with respect to acquisitions as of the date of this prospectus.
As a result, unless otherwise indicated in the applicable prospectus supplement, our management will have broad discretion to allocate
the net proceeds of the offerings. Pending their ultimate use, we intend to invest the net proceeds in a variety of securities, including
commercial paper, government and non-government debt securities and/or money market funds that invest in such securities.
DESCRIPTION OF SECURITIES WE MAY OFFER
The descriptions of the securities
contained in this prospectus, together with the applicable prospectus supplements, summarize all the material terms and provisions of
the various types of securities that we may offer. We will describe in the applicable prospectus supplement relating to any securities
the particular terms of the securities offered by that prospectus supplement. If indicated in the applicable prospectus supplement, the
terms of the securities may differ from the terms we have summarized below. We will also include information in the prospectus supplement,
where applicable, about material United States federal income tax considerations relating to the securities, and the securities exchange,
if any, on which the securities will be listed. This prospectus may not be used to consummate a sale of securities unless it is
accompanied by a prospectus supplement.
DESCRIPTION OF CAPITAL STOCK
The following description
summarizes the material terms of our capital stock as of the date of this prospectus. Because it is only a summary, it does not contain
all the information that may be important to you. For a complete description of our capital stock, you should refer to our Third Amended
and Restated Certificate of Incorporation, as amended (“Certificate of Incorporation”), and our Second Amended and Restated
Bylaws (“Bylaws”), and to the applicable provisions of Delaware law.
Authorized Capital Stock
Our authorized capital stock
consists of 200,000,000 shares of Common Stock, par value $0.0001 per share (“Common Stock”) and 2,000,000 shares of preferred
stock (the “Preferred Stock”) of which 250,000 have been designated as Class A Preferred Stock and the remainder of which
are undesignated Preferred Stock. On February 20, 2024, the Certificate of Incorporation was amended to increase the number of shares
of Common Stock authorized thereunder from 75,000,000 to 200,000,000, and on April 26, 2024, we effected a 75-for-1 reverse split
of our Common Stock.
Common Stock
Voting Rights
Holders of our Common Stock
are entitled to one vote for each share held on all matters submitted to a vote of stockholders and do not have cumulative voting rights.
However, the holders of our outstanding Class A Preferred Stock, which is held exclusively by Fortress as of the date of this prospectus,
are entitled to cast, for each share of Class A Preferred Stock, the number of votes that is equal to one and one-tenth (1.1) times
a fraction, the numerator of which is the sum of (A) the aggregate number of shares of outstanding Common Stock and (B) the
whole shares of Common Stock into which the shares of outstanding the Class A Preferred Stock are convertible and the denominator
of which is the aggregate number of shares of outstanding Class A Preferred Stock. Thus, Fortress, so long as it holds all shares
of our Class A Preferred Stock, will at all times have voting control of us. Further, for a period of ten (10) years from the
date of the first issuance of shares of Class A Preferred Stock, the holders of record of the shares of Class A Preferred Stock
(or other capital stock or securities issued upon conversion of or in exchange for the Class A Preferred Stock), exclusively and
as a separate class, are entitled to appoint or elect the majority of our directors, however, the Company and Fortress have historically
elected to waive application of this provision of the Certificate of Incorporation, and instead the holders of the Common Stock have voted
together with the holders of the Class A Preferred Stock for all directors at our annual meetings of stockholders, with the holders
of the Class A Preferred Stock utilizing the super voting rights described above.
Liquidation and Other Rights
In the event of our liquidation
or dissolution, the holders of Common Stock are entitled to receive proportionately all assets available for distribution to stockholders
after the payment of all debts and other liabilities and subject to the prior rights of any outstanding preferred stock. Holders of Common
Stock have no preemptive, subscription, redemption or conversion rights. The rights, preferences and privileges of holders of Common Stock
are subject to, and may be adversely affected by, the rights of the holders of shares of any series of preferred stock that we may designate
and issue in the future.
Listing
Our Common Stock is traded
on the Nasdaq Capital Market under the symbol "ATXI." The transfer agent and registrar for our Common Stock is VStock Transfer,
LLC.
Dividends
Holders
of Common Stock are entitled to receive proportionately any dividends as may be declared by our board of directors, subject to any preferential
dividend rights of outstanding preferred stock. Pursuant to the certificate of designation relating to the Class A Preferred Stock,
we are prohibited from paying dividends on our Common Stock until all dividends required to be paid to the holders of our Class A
Preferred Stock have been paid or declared and set apart for payment.
Anti-Takeover Effects
of Various Provisions of Delaware Law and Avenue Therapeutics’ Certificate of Incorporation and Bylaws
Provisions
of the General Corporation Law of the State of Delaware (“DGCL”) and our Certificate of Incorporation and Bylaws could make
it more difficult to acquire Avenue Therapeutics by means of a tender offer, a proxy contest or otherwise, or to remove incumbent officers
and directors. These provisions, including those summarized below, may encourage certain types of coercive takeover practices and takeover
bids.
Delaware
Anti-Takeover Statute. In general, Section 203 of the DGCL prohibits a publicly held Delaware corporation
from engaging in a “business combination” with an “interested stockholder” for a period of three years following
the time the person became an interested stockholder, unless the business combination or the acquisition of shares that resulted in a
stockholder becoming an interested stockholder is approved in a prescribed manner. Generally, a “business combination” includes
a merger, asset or stock sale or other transaction resulting in a financial benefit to the interested stockholder. Generally, an “interested
stockholder” is a person who, together with affiliates and associates, owns (or within three years prior to the determination of
interested stockholder status did own) 15% or more of a corporation’s voting stock. However, our Certificate of Incorporation provides
that we are not subject to the anti-takeover provisions of Section 203 of the DGCL.
Removal.
Subject to the rights of any holders of any outstanding series of our preferred stock, stockholders may remove our directors with or without
cause. Removal will require the affirmative vote of holders of a majority of our voting stock.
Size
of Board and Vacancies. Our Bylaws provide that the number of directors be fixed exclusively by the board of directors.
Any vacancies created on its board of directors resulting from any increase in the authorized number of directors or the death, resignation,
retirement, disqualification, removal from office or other cause will be filled by a majority of the board of directors then in office,
even if less than a quorum is present, or by a sole remaining director. Any director appointed to fill a vacancy on our board of directors
will be appointed until the next annual meeting and until his or her successor has been elected and qualified.
Requirements
for Advance Notification of Stockholder Nominations and Proposals. Our Bylaws establish advance notice procedures
with respect to stockholder proposals and nomination of candidates for election as directors other than nominations made by or at the
direction of its board of directors or a committee of our board of directors.
Undesignated
Preferred Stock. Our board of directors is authorized to issue up to 2,000,000 shares of preferred stock without
additional stockholder approval, which preferred stock could have voting rights or conversion rights that, if exercised, could adversely
affect the voting power of the holders of Common Stock. The issuance of shares of preferred stock may have the effect of delaying, deferring
or preventing a change in control of the Company without any action by the Company’s stockholders.
Limitation on Liability of Directors and Indemnification
of Directors and Officers
Elimination
of Liability of Directors. The DGCL authorizes corporations to limit or eliminate the personal liability of directors
to corporations and their stockholders for monetary damages for breaches of directors’ fiduciary duties as directors, and our Certificate
of Incorporation includes such an exculpation provision. Our Certificate of Incorporation provides that, to the fullest extent permitted
by the DGCL, no director will be personally liable to us or to our stockholders for monetary damages for breach of fiduciary duty as a
director. While our Certificate of Incorporation provides directors with protection from awards for monetary damages for breaches of their
duty of care, it does not eliminate this duty. Accordingly, our Certificate of Incorporation has no effect on the availability of equitable
remedies such as an injunction or rescission based on a director’s breach of his or her duty of care. The provisions apply to an
officer of Avenue Therapeutics only if he or she is a director of Avenue Therapeutics and is acting in his or her capacity as director,
and do not apply to officers of Avenue Therapeutics who are not directors. Additionally, our Certificate of Incorporation provides that,
to the fullest extent permitted by law, we renounce any interest or expectancy in a transaction or matter that may be a corporate opportunity
for us if it was presented to, or acquired, created or developed by, or which otherwise comes into the possession of, (i) any director
on our board of directors who is not an employee of the Company or any of its subsidiaries, or (ii) any holder of our Class A
Preferred Stock or any affiliate or other related person of any such holder, other than someone who is an employee of the Company or any
of its subsidiaries, and no person shall have any duty to present such corporate opportunity to us and will not be liable to us for pursuing
or acquiring such opportunity, or referring such opportunity to a third party.
Indemnification
of Directors, Officers and Employees. Our Bylaws require us to indemnify any person who was or is a party or is threatened
to be made a party to, or was otherwise involved in, a legal proceeding by reason of the fact that he or she is or was a director, officer
or employee of Avenue Therapeutics or, while a director, officer or employee of Avenue Therapeutics, is or was serving at our request
in a fiduciary capacity with another enterprise (including any corporation, partnership, limited liability company, joint venture, trust,
association or other unincorporated organization or other entity and any employee benefit plan, to the fullest extent authorized by the
DGCL, as it exists or may be amended, against all expense, liability and loss (including attorneys’ fees, judgments, fines, U.S.
Employee Retirement Income Security Act of 1974, as amended, excise taxes or penalties and amounts paid in settlement by or on behalf
of such person) actually and reasonably incurred in connection with such service. We are authorized under our Bylaws to carry directors’
and officers’ insurance protecting us, any director, officer or employee of ours or, against any expense, liability or loss, whether
or not we have the power to indemnify the person under the DGCL. We may, to the extent authorized from time to time, indemnify any of
our agents to the fullest extent permitted with respect to directors, officers and employees in our Bylaws.
The
limitation of liability and indemnification provisions in our Certificate of Incorporation and Bylaws may discourage stockholders from
bringing a lawsuit against our directors for breach of fiduciary duty. These provisions also may reduce the likelihood of derivative litigation
against our directors and officers, even though such an action, if successful, might otherwise benefit us and our stockholders. By its
terms, the indemnification provided for in our Bylaws is not exclusive of any other rights that the indemnified party may be or become
entitled to under any law, agreement, vote of stockholders or directors, provisions of our Certificate of Incorporation or Bylaws or otherwise.
Any amendment, alteration or repeal of our Bylaws’ indemnification provisions is, by the terms of our Bylaws, prospective only and
will not adversely affect the rights of any indemnity in effect at the time of any act or omission occurring prior to such amendment,
alteration or repeal.
DESCRIPTION OF PREFERRED STOCK
Class A Preferred Stock
The Class A Preferred
Stock is identical to our Common Stock other than as to voting rights, the election of directors for a definite period, conversion rights
and the PIK Dividend right (as described below). On any matter presented to our stockholders for their action or consideration at any
meeting of our stockholders (or by written consent of stockholders in lieu of meeting), each holder of outstanding shares of Class A
Preferred Stock will be entitled to cast for each share of Class A Preferred Stock held by such holder as of the record date for
determining stockholders entitled to vote on such matter, the number of votes that is equal to one and one-tenth (1.1) times a fraction,
the numerator of which is the sum of (A) the shares of outstanding Common Stock and (B) the whole shares of Common Stock in
to which the shares of outstanding Class A Preferred Stock are convertible and the denominator of which is the number of shares of
outstanding Class A Preferred Stock. Thus, the Class A Preferred Stock will at all times constitute a voting majority.
For a period of ten years
from the date of the first issuance of shares of Class A Preferred Stock (the “Class A Director Period”), the holders
of record of the shares of Class A Preferred Stock (or other capital stock or securities issued upon conversion of or in exchange
for the Class A Preferred Stock), exclusively and as a separate class, shall be entitled to appoint or elect the majority of our
directors. Thus, the Class A Preferred Stock will be entitled to elect the majority of the board of directors during the Class A
Director Period. However, the Company and Fortress have historically elected to waive application of this provision of the Certificate
of Incorporation, and instead the holders of the Common Stock have voted together with the holders of the Class A Preferred Stock
for all directors at our annual meetings of stockholders, with the holders of the Class A Preferred Stock utilizing the super voting
rights described above.
The holders of the outstanding
shares of Class A Preferred Stock are entitled to receive on January 1 of each year, (each, a “PIK Dividend Payment Date”),
after the original issuance date of the Class A Preferred Stock until the date all outstanding Class A Preferred Stock is converted
into Common Stock or redeemed (and the purchase price is paid in full), pro rata per share dividends paid in additional fully paid and
nonassessable shares of Common Stock (such dividend, the “PIK Dividends”), such that the aggregate number of shares of Common
Stock issued pursuant to such PIK Dividend is equal to 2.5% of our fully-diluted outstanding capitalization on the date that is one business
day prior to any PIK Dividend Payment Date. In the event the Class A Preferred Stock converts into Common Stock, the holders will
be entitled to receive all PIK Dividends accrued through the date of such conversion.
Each share of Class A
Preferred Stock is convertible, at the option of the holder, into one fully paid and nonassessable share of Common Stock subject to certain
adjustments.
Undesignated Preferred Stock
The undesignated preferred
stock may be issued from time to time in one or more series. Our board of directors is authorized to determine or alter the dividend rights,
dividend rate, conversion rights, voting rights, rights and terms of redemption (including sinking fund provisions, if any), the redemption
price or prices, the liquidation preferences and other designations, powers, preferences and relative, participating, optional or other
special rights, if any, and the qualifications, limitations and restrictions granted to or imposed upon any wholly unissued series of
preferred stock, and to fix the number of shares of any series of preferred stock (but not below the number of shares of any such series
then outstanding).
DESCRIPTION
OF WARRANTS
We may issue warrants to purchase
shares of our Common Stock and/or preferred stock in one or more series together with other securities or separately, as described in
each applicable prospectus supplement. As of December 2, 2024, there were 1,476,200 shares of Common Stock that may be issued upon
exercise of outstanding warrants.
The prospectus supplement
relating to any warrants we offer will include specific terms relating to the offering. These terms will include some or all of the following:
| · | the title of the warrants; |
| · | the aggregate number of warrants offered; |
| · | the designation, number and terms of the shares of Common Stock purchasable upon exercise of the warrants
and procedures by which those numbers may be adjusted; |
| · | the exercise price of the warrants; |
| · | the dates or periods during which the warrants are exercisable; |
| · | the designation and terms of any securities with which the warrants are issued; |
| · | if the warrants are issued as a unit with another security, the date on and after which the warrants and
the other security will be separately transferable; |
| · | if the exercise price is not payable in U.S. dollars, the foreign currency, currency unit or composite
currency in which the exercise price is denominated; |
| · | any minimum or maximum amount of warrants that may be exercised at any one time; |
| · | any terms relating to the modification of the warrants; |
| · | any terms, procedures and limitations relating to the transferability, exchange or exercise of the warrants;
and |
| · | any other specific terms of the warrants. |
DESCRIPTION
OF DEBT SECURITIES
We may offer debt securities
which may be senior, subordinated or junior subordinated and may be convertible. Unless otherwise specified in the applicable prospectus
supplement, our debt securities will be issued in one or more series under an indenture to be entered into between us and a trustee. We
will issue the debt securities offered by this prospectus and any accompanying prospectus supplement under an indenture to be entered
into between us and the trustee identified in the applicable prospectus supplement. The terms of the debt securities will include those
stated in the indenture and those made part of the indenture by reference to the Trust Indenture Act of 1939, as amended (the “Act”)
as in effect on the date of the indenture. We have filed a copy of the form of indenture as an exhibit to the registration statement in
which this prospectus is included. The indenture will be subject to and governed by the terms of the Act.
The following description
briefly sets forth certain general terms and provisions of the debt securities that we may offer. The particular terms of the debt securities
offered by any prospectus supplement and the extent, if any, to which these general provisions may apply to the debt securities, will
be described in the related prospectus supplement. Accordingly, for a description of the terms of a particular issue of debt securities,
reference must be made to both the related prospectus supplement and to the following description.
Debt Securities
The aggregate principal amount
of debt securities that may be issued under the indenture is unlimited. The debt securities may be issued in one or more series as may
be authorized from time to time pursuant to a supplemental indenture entered into between us and the trustee or an order delivered by
us to the trustee. For each series of debt securities we offer, a prospectus supplement accompanying this prospectus will describe the
following terms and conditions of the series of debt securities that we are offering, to the extent applicable:
| · | title and aggregate principal amount; |
| · | whether the debt securities will be senior, subordinated or junior subordinated; |
| · | applicable subordination provisions, if any; |
| · | provisions regarding whether the debt securities will be convertible or exchangeable into other securities
or property of the Company or any other person; |
| · | percentage or percentages of principal amount at which the debt securities will be issued; |
| · | maturity date(s); |
| · | interest rate(s) or the method for determining the interest rate(s); |
| · | whether interest on the debt securities will be payable in cash or additional debt securities of the same
series; |
| · | dates on which interest will accrue or the method for determining dates on which interest will accrue
and dates on which interest will be payable; |
| · | whether the amount of payment of principal of, premium, if any, or interest on the debt securities may
be determined with reference to an index, formula or other method; |
| · | redemption, repurchase or early repayment provisions, including our obligation or right to redeem, purchase
or repay debt securities under a sinking fund, amortization or analogous provision; |
| · | if other than the debt securities’ principal amount, the portion of the principal amount of the
debt securities that will be payable upon declaration of acceleration of the maturity; |
| · | authorized denominations; |
| · | form; |
| · | amount of discount or premium, if any, with which the debt securities will be issued, including whether
the debt securities will be issued as “original issue discount” securities; |
| · | the place or places where the principal of, premium, if any, and interest on the debt securities will
be payable; |
| · | where the debt securities may be presented for registration of transfer, exchange or conversion; |
| · | the place or places where notices and demands to or upon the Company in respect of the debt securities
may be made; |
| · | whether the debt securities will be issued in whole or in part in the form of one or more global securities; |
| · | if the debt securities will be issued in whole or in part in the form of a book-entry security, the depository
or its nominee with respect to the debt securities and the circumstances under which the book-entry security may be registered for transfer
or exchange or authenticated and delivered in the name of a person other than the depository or its nominee; |
| · | whether a temporary security is to be issued with respect to such series and whether any interest payable
prior to the issuance of definitive securities of the series will be credited to the account of the persons entitled thereto; |
| · | the terms upon which beneficial interests in a temporary global security may be exchanged in whole or
in part for beneficial interests in a definitive global security or for individual definitive securities; |
| · | the guarantors, if any, of the debt securities, and the extent of the guarantees and any additions or
changes to permit or facilitate guarantees of such debt securities; |
| · | any covenants applicable to the particular debt securities being issued; |
| · | any defaults and events of default applicable to the debt securities, including the remedies available
in connection therewith; |
| · | currency, currencies or currency units in which the purchase price for, the principal of and any premium
and any interest on, such debt securities will be payable; |
| · | time period within which, the manner in which and the terms and conditions upon which the Company or the
purchaser of the debt securities can select the payment currency; |
| · | securities exchange(s) on which the debt securities will be listed, if any; |
| · | whether any underwriter(s) will act as market maker(s) for the debt securities; |
| · | extent to which a secondary market for the debt securities is expected to develop; |
| · | provisions relating to defeasance; |
| · | provisions relating to satisfaction and discharge of the indenture; |
| · | any restrictions or conditions on the transferability of the debt securities; |
| · | provisions relating to the modification of the indenture both with and without the consent of holders
of debt securities issued under the indenture; |
| · | any addition or change in the provisions related to compensation and reimbursement of the trustee; |
| · | provisions, if any, granting special rights to holders upon the occurrence of specified events; |
| · | whether the debt securities will be secured or unsecured, and, if secured, the terms upon which the debt
securities will be secured and any other additions or changes relating to such security; and |
| · | any other terms of the debt securities that are not inconsistent with the provisions of the Act (but may
modify, amend, supplement or delete any of the terms of the indenture with respect to such series of debt securities). |
General
One or more series of debt
securities may be sold as “original issue discount” securities. These debt securities would be sold at a substantial discount
below their stated principal amount, bearing no interest or interest at a rate which at the time of issuance is below market rates. One
or more series of debt securities may be variable rate debt securities that may be exchanged for fixed rate debt securities.
United States federal income
tax consequences and special considerations, if any, applicable to any such series will be described in the applicable prospectus supplement.
Debt securities may be issued
where the amount of principal and/or interest payable is determined by reference to one or more currency exchange rates, commodity prices,
equity indices or other factors. Holders of such debt securities may receive a principal amount or a payment of interest that is greater
than or less than the amount of principal or interest otherwise payable on such dates, depending upon the value of the applicable currencies,
commodities, equity indices or other factors. Information as to the methods for determining the amount of principal or interest, if any,
payable on any date, the currencies, commodities, equity indices or other factors to which the amount payable on such date is linked and
certain additional United States federal income tax considerations will be set forth in the applicable prospectus supplement.
The term “debt securities”
includes debt securities denominated in U.S. dollars or, if specified in the applicable prospectus supplement, in any other freely transferable
currency or units based on or relating to foreign currencies.
We expect most debt securities
to be issued in fully registered form without coupons and in denominations of $2,000 and any integral multiples thereof. Subject to the
limitations provided in the indenture and in the prospectus supplement, debt securities that are issued in registered form may be transferred
or exchanged at the principal corporate trust office of the trustee, without the payment of any service charge, other than any tax or
other governmental charge payable in connection therewith.
Global Securities
The debt securities of a series
may be issued in whole or in part in the form of one or more global securities that will be deposited with, or on behalf of, a depositary
identified in the prospectus supplement. Global securities will be issued in registered form and in either temporary or definitive form.
Unless and until it is exchanged in whole or in part for the individual debt securities, a global security may not be transferred except
as a whole by the depositary for such global security to a nominee of such depositary or by a nominee of such depositary to such depositary
or another nominee of such depositary or by such depositary or any such nominee to a successor of such depositary or a nominee of such
successor. The specific terms of the depositary arrangement with respect to any debt securities of a series and the rights of and limitations
upon owners of beneficial interests in a global security will be described in the applicable prospectus supplement.
Governing Law
The indenture and the debt
securities shall be construed in accordance with and governed by the laws of the State of New York.
DESCRIPTION OF UNITS
We may issue, in one more
series, units comprised of shares of our Common Stock and/or preferred stock, warrants to purchase Common Stock and/or preferred stock,
debt securities or any combination of those securities. Each unit will be issued so that the holder of the unit is also the holder of
each security included in the unit. Thus, the holder of a unit will have the rights and obligations of a holder of each included security.
The unit agreement under which a unit is issued may provide that the securities included in the unit may not be held or transferred separately,
at any time or at any time before a specified date.
We may evidence units by unit
certificates that we issue under a separate agreement. We may issue the units under a unit agreement between us and one or more unit agents.
If we elect to enter into a unit agreement with a unit agent, the unit agent will act solely as our agent in connection with the units
and will not assume any obligation or relationship of agency or trust for or with any registered holders of units or beneficial owners
of units. We will indicate the name and address and other information regarding the unit agent in the applicable prospectus supplement
relating to a particular series of units if we elect to use a unit agent.
We will describe in the applicable
prospectus supplement the terms of the series of units being offered, including:
| · | the designation and terms of the units and of the securities comprising the units, including whether and
under what circumstances those securities may be held or transferred separately; |
| · | any provisions of the governing unit agreement that differ from those described herein; and |
| · | any provisions for the issuance, payment, settlement, transfer or exchange of the units or of the securities
comprising the units. |
The other provisions regarding
our Common Stock, preferred stock, warrants and debt securities as described in this section will apply to each unit to the extent such
unit consists of shares of our Common Stock, warrants and/or debt securities.
PLAN OF DISTRIBUTION
We may sell the securities
covered in this prospectus in one or more of the following ways:
| · | through underwriters or dealers; |
| · | in short or long transactions; |
| · | directly to a limited number of purchasers or to a single purchaser; |
| · | through agents, including via an at-the-market program; or |
| · | through a combination of any of these methods of sale. |
Each time that we use this
prospectus to sell securities, we will also provide a prospectus supplement that contains the specific terms of the offering. The prospectus
supplement will set forth the terms of the offering of the securities, including:
| · | the name or names of any underwriters, dealers or agents and the amounts of any securities underwritten
or purchased by each of them; and |
| · | the purchase price of the securities being offered and the proceeds to us and any discounts, commissions
or concessions allowed or reallowed or paid to dealers. |
Any public offering price
and any discounts or concessions allowed or reallowed or paid to dealers may be changed from time to time.
If underwriters are used in
the sale of any securities, the securities will be acquired by the underwriters for their own account and may be resold from time to time
in one or more transactions, including negotiated transactions, at a fixed public offering price or at varying prices determined at the
time of sale. The securities may be either offered to the public through underwriting syndicates represented by managing underwriters,
or directly by underwriters. Generally, the underwriters’ obligations to purchase the securities will be subject to certain conditions
precedent. The underwriters will be obligated to purchase all of the securities if they purchase any of securities. Only underwriters
named in the applicable prospectus supplement shall be underwriters of the securities offered thereby.
We may sell the securities
through agents from time to time. The prospectus supplement will name any agent involved in the offer or sale of the securities and any
commissions we pay to them. Generally, any agent will be acting on a best efforts basis for the period of its appointment.
We may authorize underwriters,
dealers or agents to solicit offers by certain purchasers to purchase the securities from us at the public offering price set forth in
the prospectus supplement pursuant to delayed delivery contracts providing for payment and delivery on a specified applicable date in
the future. The contracts will be subject only to those conditions set forth in the prospectus supplement, and the prospectus supplement
will set forth any commissions we pay for solicitation of these contracts.
Agents and underwriters may
be entitled to indemnification by us against certain civil liabilities, including liabilities under the Securities Act of 1933, as amended
(“Securities Act”), or to contribution with respect to payments which the agents or underwriters may be required to make in
respect thereof. Agents and underwriters may be customers of, engage in transactions with, or perform services for us in the ordinary
course of business.
We may enter into derivative
transactions with third parties, or sell securities not covered by this prospectus to third parties in privately negotiated transactions.
If the applicable prospectus supplement indicates, in connection with those derivatives, the third parties may sell securities covered
by this prospectus and the applicable prospectus supplement, including in short sale transactions. If so, the third party may use securities
pledged by us or borrowed from us or others to settle those sales or to close out any related open borrowings of securities and may use
securities received from us in settlement of those derivatives to close out any related open borrowings of securities. The third party
in such sale transactions will be an underwriter and will be identified in the applicable prospectus supplement (or a post-effective amendment).
We may also use underwriters or such other third parties with whom we have a material relationship. We will describe the nature of any
such relationship in the applicable prospectus supplement.
At-the-Market Offerings
Upon written instruction from
us, after entering into a distribution agency agreement with us, a sales agent may use its commercially reasonable efforts to sell on
our behalf, as our agent, the shares of Common Stock offered as agreed upon by us and the sales agent. We will designate the maximum amount
of shares of Common Stock to be sold through the sales agent, on a daily basis or otherwise as we and the sales agent agree. Subject to
the terms and conditions of the applicable distribution agency agreement, the sales agent will use its commercially reasonable efforts
to sell, as our sales agent and on our behalf, all of the designated shares of Common Stock. We may instruct the sales agent not to sell
shares of Common Stock if the sales cannot be effected at or above the price designated by us in any such instruction. We may suspend
the offering of shares of Common Stock under any distribution agency agreement by notifying the sales agent. Likewise, the sales agent
may suspend the offering of shares of Common Stock under the applicable distribution agency agreement by notifying us of such suspension.
We also may sell shares to
the sales agent as principal for its own account at a price agreed upon at the time of sale. If we sell shares to the sales agent as principal,
we will enter into a separate agreement setting forth the terms of such transaction.
It is contemplated that the
distribution agreements entered into with sales agents will allow such sales agents to make sales in privately negotiated transactions
and/or under any other method permitted by law, including sales deemed to be an "at-the-market" offering as defined in Rule 415
promulgated under the Securities Act, sales made directly on the Nasdaq Capital Market, the existing trading market for our Common Stock,
or sales made to or through a market maker other than on an exchange. The name of any such underwriter or agent involved in the offer
and sale of our Common Stock, the amounts underwritten, and the nature of its obligations to take our Common Stock will be described in
the applicable prospectus supplement.
LEGAL MATTERS
Troutman Pepper Hamilton Sanders
LLP, Charlotte, North Carolina, will pass upon the validity of the securities being offered by this prospectus. Additional legal matters
may be passed upon for us or any underwriters, dealers or agents, by counsel that we will name in the applicable prospectus supplement.
EXPERTS
The consolidated financial
statements of Avenue Therapeutics, Inc. as of December 31, 2023 and 2022 and for each of the years then ended, have been incorporated
by reference herein and in the registration statement in reliance upon the report of KPMG LLP, independent registered public accounting
firm, incorporated by reference herein, and upon the authority of said firm as experts in auditing and accounting. The audit report covering
the December 31, 2023 consolidated financial statements contains an explanatory paragraph that states the Company has incurred substantial
operating losses since its inception and expects to continue to incur significant operating losses for the foreseeable future that raise
substantial doubt about the Company’s ability to continue as a going concern. The consolidated financial statements do not include
any adjustments that might result from the outcome of that uncertainty.
WHERE YOU CAN FIND MORE INFORMATION
We file reports and proxy
statements with the SEC. These filings include our Annual Report on Form 10-K, Quarterly Reports on Form 10-Q, Current Reports
on Form 8-K and proxy statements on Schedule 14A, as well as any amendments to those reports and proxy statements, which are available
free of charge through our website as soon as reasonably practicable after we file them with, or furnish them to, the SEC. Our Internet
website address is www.avenuetx.com. Our website and the information contained on, or that can be accessed through, the website will not
be deemed to be incorporated by reference in, and are not considered part of, this prospectus. You should not rely on any such information
in making your decision whether to purchase our securities. The SEC also maintains a website at www.sec.gov that contains reports, proxy
and information statements and other information regarding us and other issuers that file electronically with the SEC.
INCORPORATION OF CERTAIN INFORMATION BY REFERENCE
The SEC allows us to “incorporate
by reference” the information we file with it which means that we can disclose important information to you by referring you to
those documents instead of having to repeat the information in this prospectus and any accompanying prospectus supplement. The information
incorporated by reference is considered to be part of this prospectus and any accompanying prospectus supplement, and later information
that we file with the SEC will automatically update and supersede this information. This prospectus incorporates by reference the documents
listed below and any future filings made with the SEC under Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act (1) after
the date of the initial registration statement, as amended, and prior to effectiveness of the registration statement, and (2) after
the date of this prospectus and prior to the termination of this offering. Such information will automatically update and supersede the
information contained in this prospectus and the documents listed below; provided, however, that we are not, unless specifically indicated,
incorporating any information furnished under Item 2.02 or Item 7.01 of any current report on Form 8-K, whether listed
below or filed in the future, or related exhibits furnished pursuant to Item 9.01 of Form 8-K:
| b) | Our Quarterly Reports on Form 10-Q for the quarters ended March 31, 2021, filed with the SEC
on May 15, 2024, June 30, 2024, filed with the SEC on August 9, 2024, and September 30, 2024, filed with the
SEC on November 14, 2024; |
| c) | Our Current Reports on Form 8-K filed with the SEC on January 8, 2024, January 12, 2024, February 23, 2024, March 8, 2024, March 15, 2024, March 29, 2024, April 26, 2024, May 1, 2024,
May 13, 2024, May 23, 2024, June 26, 2024, September 27, 2024 and November 29, 2024; and |
| d) | The description of our Common Stock contained in Exhibit 4.3 to our Annual Report on Form 10-K filed
with the SEC on March 18, 2024, including any amendment or report updating such description. |
All reports and other
documents we subsequently file pursuant to Section 13(a), 13(c), 14 or 15(d) of the Exchange Act prior to the termination of
this offering, including all such documents we may file with the SEC after the date of the initial registration statement and prior to
the effectiveness of the registration statement, but excluding any information furnished to, rather than filed with, the SEC, will also
be incorporated by reference into this prospectus and deemed to be part of this prospectus from the date of the filing of such reports
and documents. A statement contained in a document incorporated by reference into this prospectus shall be deemed to be modified or superseded
for purposes of this prospectus to the extent that a statement contained in this prospectus, any prospectus supplement or in any other
subsequently filed document which is also incorporated in this prospectus modifies or replaces such statement. Any statements so modified
or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this prospectus. We will furnish without
charge to any person (including any beneficial owner) a copy of any or all of the documents incorporated by reference, including exhibits
to these documents, upon written or oral request. Direct your request to: Corporate Secretary, Avenue Therapeutics, Inc., 1111 Kane
Concourse, Suite 301, Bay Harbor Islands Florida 33154, or (781) 652-4500.
Avenue Therapeutics, Inc.
$35,000,000
Common Stock
Preferred Stock
Warrants
Debt Securities
Units
PROSPECTUS
, 2024
PART II
INFORMATION NOT REQUIRED IN PROSPECTUS
Item
14. Other Expenses of Issuance and Distribution
The following table sets forth
the estimated costs and expenses, other than underwriting discounts and commissions, payable by us in connection with the offering of
the securities being registered. All the amounts shown are estimates, except for the SEC registration fee.
SEC registration fee |
​ |
$ |
1,785.63 |
(1)​ |
FINRA Fee |
|
|
* |
|
Printing Expenses |
|
|
* |
|
Accounting fees and expenses |
​ |
​ |
* |
​ |
Legal fees and expenses |
​ |
​ |
* |
​ |
Transfer agent fees and expenses |
​ |
​ |
* |
​ |
Trustee fees and expenses |
​ |
​ |
* |
​ |
Warrant agent fees and expenses |
|
|
* |
|
Miscellaneous expenses |
​ |
​ |
* |
​ |
Total |
​ |
$ |
* |
​ |
* These fees are calculated based on the securities offered and the
number of issuances and accordingly cannot be estimated at this time.
(1) The
$35,000,000 of securities registered pursuant to this registration statement includes $23,336,986.55 of securities (the “Unsold
Securities”) registered pursuant to the Registration Statement on Form S-3 (File No. 333-261520), originally filed on December 7,
2021, and declared effective on December 10, 2021. Pursuant to Rule 415(a)(6) under the Securities Act of 1933, as amended, the filing
fees previously paid in connection with the Unsold Securities will continue to be applied to the Unsold Securities.
Item
15. Indemnification of Directors and Officers
Under the DGCL, a corporation
may include provisions in its certificate of incorporation that will relieve its directors of monetary liability for breaches of their
fiduciary duty to the corporation, except under certain circumstances, including a breach of the director’s duty of loyalty, acts
or omissions of the director not in good faith or which involve intentional misconduct or a knowing violation of law, the approval of
an improper payment of a dividend or an improper purchase by the corporation of stock or any transaction from which the director derived
an improper personal benefit. The Company’s Third Amended and Restated Certificate of Incorporation, as amended (“Certificate
of Incorporation”), as amended, eliminates the personal liability of directors to the Company or its stockholders for monetary damages
for breach of fiduciary duty as a director with certain limited exceptions set forth in the DGCL.
Section 145 of the DGCL
grants to corporations the power to indemnify each officer and director against liabilities and expenses incurred by reason of the fact
that he or she is or was an officer or director of the corporation if he or she acted in good faith and in a manner he or she reasonably
believed to be in or not opposed to the best interests of the corporation and, with respect to any criminal action or proceeding, had
no reasonable cause to believe his or her conduct was unlawful. The Company’s Certificate of Incorporation and Second Amended and
Restated Bylaws provide for indemnification of each officer and director of the Company to the fullest extent permitted by the DGCL. Section 145
of the DGCL also empowers corporations to purchase and maintain insurance on behalf of any person who is or was an officer or director
of the corporation against liability asserted against or incurred by him in any such capacity, whether or not the corporation would have
the power to indemnify such officer or director against such liability under the provisions of Section 145 of the DGCL.
Item
16. Exhibits and Financial Statement Schedules
Exhibit |
|
Description
of Exhibit |
1.1* |
|
Form of
Underwriting Agreement. |
|
|
|
3.1 |
|
Third
Amended and Restated Certificate of Incorporation of Avenue Therapeutics, Inc., filed as Exhibit 3.1 to Form 8-K filed
on June 27, 2017 (File No. 001-38114) and incorporated herein by reference. |
|
|
|
3.2 |
|
Certificate
of Amendment of the Third Amended and Restated Certificate of Incorporation of Avenue Therapeutics, Inc., filed as Exhibit 3.1
to Form 10-Q filed on August 14, 2018 (File No. 001-38114) and incorporated herein by reference. |
|
|
​ |
3.3 |
|
Certificate
of Amendment of the Third Amended and Restated Certificate of Incorporation of Avenue Therapeutics, Inc., filed as Exhibit 3.1
to Form 8-K filed on September 22, 2022 (File No. 001-38114) and incorporated herein by reference. |
|
|
​ |
3.4 |
|
Certificate
of Amendment of the Third Amended and Restated Certificate of Incorporation of Avenue Therapeutics, Inc., filed as Exhibit 3.1
to Form 8-K filed on February 3, 2023 (File No. 001-38114) and incorporated herein by reference. |
|
|
|
3.5 |
|
Certificate
of Amendment of the Third Amended and Restated Certificate of Incorporation of Avenue Therapeutics, Inc., filed as Exhibit 3.1
to Form 8-K filed on February 23, 2024 (File No. 001-38114) and incorporated herein by reference. |
|
|
|
3.6 |
|
Second
Amended and Restated Bylaws of Avenue Therapeutics, Inc., filed as Exhibit 3.1 to Form 8-K filed on February 10,
2023 (File No. 000-38114) and incorporated herein by reference. |
|
|
|
4.1 |
|
Specimen
certificate evidencing shares of Common Stock, filed as Exhibit 4.1 to Form 10-12G filed on January 12, 2017 (File
No. 000-55556) and incorporated herein by reference. |
|
|
|
4.2 |
|
Form of
warrant agreement, filed as Exhibit 4.2 to Form 10-12G filed on January 12, 2017 (File No. 000-55556) and incorporated
herein by reference. |
|
|
|
4.3 |
|
Form of
Warrant, filed as Exhibit 4.1 to Form 8-K filed on October 12, 2022 (File No. 001-38114) and incorporated herein
by reference. |
|
|
​ |
4.4 |
|
Warrant Agent Agreement, dated October 6, 2022, by and between Avenue Therapeutics, Inc. and VStock Transfer, LLC, filed as Exhibit 4.3 to Form 8-K filed on October 12, 2022 (File No. 001-38114) and incorporated herein by reference. |
|
|
|
4.5 |
|
Form of
Series A Warrant (November 2023), filed as Exhibit 4.1 to Form 8-K filed on November 2, 2023 (File No. 001-38114)
and incorporated herein by reference. |
|
|
|
4.6 |
|
Form of
Series B Warrant (November 2023), filed as Exhibit 4.2 to Form 8-K filed on November 2, 2023 (File No. 001-38114)
and incorporated herein by reference. |
|
|
|
4.7 |
|
Warrant
Agent Agreement, dated October 31, 2023 by and between Avenue Therapeutics, Inc. and VStock Transfer, LLC, filed as Exhibit 4.4
to Form 8-K filed on November 2, 2023 (File No. 001-38114) and incorporated herein by reference. |
|
|
|
4.8 |
|
Form of
New Series A Warrant (January 2024), filed as Exhibit 4.1 to Form 8-K filed on January 8, 2024 (File No. 001-38114)
and incorporated herein by reference. |
|
|
|
4.9 |
|
Form of
New Series B Warrant (January 2024), filed as Exhibit 4.2 to Form 8-K filed on January 8, 2024 (File No. 001-38114)
and incorporated herein by reference. |
|
|
|
4.10 |
|
Form of
Indenture, between the Registrant and one or more trustees to be named. |
|
|
|
4.11* |
|
Form of
Note. |
* To be filed by amendment or by a report filed
under the Securities Exchange Act of 1934, as amended, and incorporated herein by reference, if applicable.
‡
To be filed pursuant to Section 305(b)(2) of the Trust Indenture Act of 1939 under the electronic form type “305B2”
and in accordance with the requirements of Item 601(b)(25) of Regulation S-K.
Item 17. Undertakings
(a) The undersigned registrant hereby undertakes:
(1) To file, during any period
in which offers or sales are being made, a post-effective amendment to this registration statement:
(i) To include any prospectus required
by Section 10(a)(3) of the Securities Act;
(ii)To reflect in the prospectus any facts
or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which,
individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding
the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed
that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the
form of prospectus filed with the SEC pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent
no more than a 20% change in the maximum aggregate offering price set forth in the “Calculation of Registration Fee” table
in the effective registration statement; and
(iii)To include any material information
with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information
in the registration statement;
provided, however, that paragraphs (a)(1)(i),
(a)(1)(ii) and (a)(1)(iii) above do not apply if the information required to be included in a post-effective amendment by those
paragraphs is contained in reports filed with or furnished to the SEC by registrant pursuant to Section 13 and Section 15(d) of
the Securities Exchange Act of 1934 that are incorporated by reference in the registration statement, or is contained in a form of prospectus
filed pursuant to Rule 424(b) that is part of the registration statement.
(2) That, for the purpose of determining
any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating
to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering
thereof.
(3) To remove from registration
by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
(4) That, for the purpose of determining
liability under the Securities Act to any purchaser:
(A) Each prospectus filed by the
registrant pursuant to Rule 424(b)(3) shall be deemed to be part of the registration statement as of the date the filed prospectus
was deemed part of and included in the registration statement; and
(B) Each prospectus required to be
filed pursuant to Rule 424(b)(2), (b)(5) or (b)(7) as part of a registration statement in reliance on Rule 430B relating
to an offering made pursuant to Rule 415(a)(1)(i), (vii) or (x) for the purpose of providing the information required by
Section 10(a) of the Securities Act shall be deemed to be part of and included in the registration statement as of the earlier
of the date such form of prospectus is first used after effectiveness or the date of the first contract of sale of securities in the offering
described in the prospectus. As provided in Rule 430B, for liability purposes of the issuer and any person that is at that date an
underwriter, such date shall be deemed to be a new effective date of the registration statement relating to the securities in the registration
statement to which that prospectus relates, and the offering of such securities at that time shall be deemed to be the initial bona fide
offering thereof. Provided, however, that no statement made in a registration statement or prospectus that is part of the registration
statement or made in a document incorporated or deemed incorporated by reference into the registration statement or prospectus that is
part of the registration statement will, as to a purchaser with a time of contract of sale prior to such effective date, supersede or
modify any statement that was made in the registration statement or prospectus that was part of the registration statement or made in
any such document immediately prior to such effective date.
(5) That, for the purpose of determining
liability of the registrant under the Securities Act to any purchaser in the initial distribution of the securities:
The undersigned registrant undertakes
that in a primary offering of securities of the undersigned registrant pursuant to this registration statement, regardless of the underwriting
method used to sell the securities to the purchaser, if the securities are offered or sold to such purchaser by means of any of the following
communications, the undersigned registrant will be a seller to the purchaser and will be considered to offer or sell such securities to
such purchaser:
(i) Any preliminary prospectus or
prospectus of the undersigned registrant relating to the offering required to be filed pursuant to Rule 424;
(ii) Any free writing prospectus
relating to the offering prepared by or on behalf of the undersigned registrant or used or referred to by the undersigned registrant;
(iii) The portion of any other
free writing prospectus relating to the offering containing material information about the undersigned registrant or its securities
provided by or on behalf of the undersigned registrant; and
(iv) Any other communication that
is an offer in the offering made by the undersigned registrant to the purchaser.
(b) The undersigned registrant
hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the registrant’s annual
report pursuant to Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 (and, where applicable, each
filing of an employee benefit plan’s annual report pursuant to Section 15(d) of the Securities Exchange Act of 1934) that
is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities
offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
(c) Insofar as indemnification
for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the registrant pursuant
to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the SEC such indemnification is against
public policy as expressed in the Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities
(other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant
in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection
with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling
precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed
in the Act and will be governed by the final adjudication of such issue.
(d) The undersigned registrant
hereby undertakes that:
(1) For purposes of determining any
liability under the Securities Act, the information omitted from the form of prospectus filed as part of this registration statement in
reliance upon Rule 430A and contained in a form of prospectus filed by the registrant pursuant to Rule 424(b)(1) or (4) or
497(h) under the Securities Act shall be deemed to be part of this registration statement as of the time it was declared effective.
(2) For the purpose of determining
any liability under the Securities Act, each post-effective amendment that contains a form of prospectus shall be deemed to be a new registration
statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial
bona fide offering thereof.
(e) The undersigned registrant
hereby undertakes to file an application for the purpose of determining the eligibility of the trustee to act under subsection (a) of
section 310 of the Act in accordance with the rules and regulations prescribed by the SEC under section 305(b)(2) of the Act.
SIGNATURES
Pursuant to the requirements
of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing
on Form S-3 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized,
in Bay Harbor Islands, Florida, on December 4, 2024.
|
AVENUE THERAPEUTICS, INC. |
| By: | /s/ Alexandra MacLean |
| | Alexandra MacLean, M.D.
Chief Executive Officer and Director |
POWER OF ATTORNEY
Each person whose signature
appears below constitutes and appoints each of Alexandra MacLean, M.D., and David Jin, acting alone or together with another attorney-in-fact,
as his or her true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for such person and in his
or her name, place and stead, in any and all capacities, to sign any or all further amendments (including post-effective amendments) to
this registration statement (and any additional registration statement related hereto permitted by Rule 462(b) promulgated under
the Securities Act, (and all further amendments, including post-effective amendments, thereto)), and to file the same, with all exhibits
thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact
and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done
in and about the premises, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all
that said attorney-in-fact and agent, or his or her substitute or substitutes, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements
of the Securities Act, this registration statement has been signed by the following persons in the capacities and on the dates indicated.
Signature |
|
Title |
|
Date |
|
|
|
|
|
/s/
Alexandra MacLean
Alexandra MacLean, M.D.
|
|
Chief Executive Officer and Director
(Principal Executive Officer) |
|
December 4, 2024 |
/s/
David Jin
David Jin |
|
Chief Operating Officer and Interim Chief
Financial Officer
(Principal Financial Officer and Principal
Accounting Officer) |
|
December 4, 2024 |
/s/
Jay Kranzler
Jay Kranzler, M.D., Ph.D.
|
|
Chairman of the Board |
|
December 4, 2024 |
/s/
Faith Charles
Faith Charles
|
|
Director |
|
December 4, 2024 |
/s/
Neil Herskowitz
Neil Herskowitz
|
|
Director |
|
December 4, 2024 |
/s/
Curtis Oltmans
Curtis Oltmans
|
|
Director |
|
December 4, 2024 |
/s/
Lindsay A. Rosenwald
Lindsay A. Rosenwald |
|
Director |
|
December 4, 2024 |
Exhibit 4.10
AVENUE THERAPEUTICS, INC.
and
Trustee
INDENTURE
Dated as of ________________________
DEBT SECURITIES
CROSS-REFERENCE TABLE(1)
Section of
Trust Indenture Act
of 1939, as amended |
|
Section of
Indenture |
310(a) |
|
6.09 |
310(b) |
|
6.08 |
|
|
6.10 |
310(c) |
|
Inapplicable |
311(a) |
|
6.13 |
311(b) |
|
6.13 |
311(c) |
|
Inapplicable |
312(a) |
|
4.01 |
|
|
4.04 |
312(b) |
|
4.04(c) |
312(c) |
|
4.04(c) |
313(a) |
|
4.03 |
313(b) |
|
4.03 |
313(c) |
|
4.03 |
313(d) |
|
4.03 |
314(a) |
|
3.05 and 4.02 |
314(b) |
|
Inapplicable |
314(c) |
|
2.04 |
|
|
8.04 |
|
|
9.01(c) |
|
|
10.01(b) |
|
|
11.05 |
314(d) |
|
Inapplicable |
314(e) |
|
11.05 |
314(f) |
|
Inapplicable |
315(a) |
|
6.01 |
|
|
6.02 |
315(b) |
|
5.11 |
315(c) |
|
6.01 |
315(d) |
|
6.01 |
|
|
6.02 |
315(e) |
|
5.12 |
316(a) |
|
5.09 |
|
|
5.10 |
|
|
7.04 |
316(b) |
|
5.06 |
|
|
5.10 |
316(c) |
|
7.02 |
317(a) |
|
5.04 |
317(b) |
|
3.04 |
318(a) |
|
11.07 |
(1) |
This Cross-Reference Table does not constitute part of the Indenture and shall not have any bearing on the interpretation of any of its terms or provisions. |
Table
of Contents
Page
Section 1.01 |
Certain Terms Defined |
1 |
Section 2.01 |
Forms Generally |
5 |
Section 2.02 |
Form of Trustee’s Certificate of Authentication |
6 |
Section 2.03 |
Amount Unlimited; Issuable in Series |
6 |
Section 2.04 |
Authentication and Delivery of Securities |
8 |
Section 2.05 |
Execution of Securities |
8 |
Section 2.06 |
Certificate of Authentication |
9 |
Section 2.07 |
Denomination and Date of Securities; Payments of Interest |
9 |
Section 2.08 |
Registration, Transfer and Exchange |
9 |
Section 2.09 |
Mutilated, Defaced, Destroyed, Lost and Stolen Securities |
11 |
Section 2.10 |
Cancellation of Securities; Destruction Thereof |
11 |
Section 2.11 |
Temporary Securities |
12 |
ARTICLE 3 |
COVENANTS OF THE ISSUER |
12 |
Section 3.01 |
Payment of Principal and Interest |
12 |
Section 3.02 |
Offices for Payments, Etc. |
12 |
Section 3.03 |
Appointment to Fill a Vacancy in Office of Trustee |
13 |
Section 3.04 |
Paying Agents |
13 |
Section 3.05 |
Written Statement to Trustee |
13 |
ARTICLE 4 |
SECURITYHOLDERS LISTS AND REPORTS BY THE ISSUER AND THE TRUSTEE |
14 |
Section 4.01 |
Issuer to Furnish Trustee Information as to Names and Addresses of Securityholders |
14 |
Section 4.02 |
Reports by the Issuer |
14 |
Section 4.03 |
Reports by the Trustee |
14 |
Section 4.04 |
Preservation of Information; Communication with Securityholders |
14 |
ARTICLE 5 |
REMEDIES OF THE TRUSTEE AND SECURITYHOLDERS ON EVENT OF DEFAULT |
14 |
Section 5.01 |
Event of Default Defined; Acceleration of Maturity; Waiver of Default |
14 |
Section 5.02 |
Collection of Debt by Trustee; Trustee May Prove Debt |
16 |
Section 5.03 |
Application of Proceeds |
17 |
Section 5.04 |
Suits for Enforcement |
18 |
Section 5.05 |
Restoration of Rights on Abandonment of Proceedings |
18 |
Section 5.06 |
Limitations on Suits by Securityholders |
18 |
Section 5.07 |
Unconditional Right of Securityholders to Institute Certain Suits |
18 |
Section 5.08 |
Powers and Remedies Cumulative; Delay or Omission Not Waiver of Default |
19 |
Section 5.09 |
Control by Holders of Securities |
19 |
Section 5.10 |
Waiver of Past Defaults |
19 |
Section 5.11 |
Trustee to Give Notice of Default |
19 |
Section 5.12 |
Right of Court to Require Filing of Undertaking to Pay Costs |
20 |
ARTICLE 6 |
CONCERNING THE TRUSTEE |
20 |
Section 6.01 |
Duties and Responsibilities of the Trustee; During Default; Prior to Default |
20 |
Section 6.02 |
Certain Rights of the Trustee |
20 |
Section 6.03 |
Trustee Not Responsible for Recitals, Disposition of Securities or Application of Proceeds Thereof |
21 |
Section 6.04 |
Trustee and Agents May Hold Securities; Collections, Etc. |
21 |
Section 6.05 |
Moneys Held by Trustee |
21 |
Section 6.06 |
Compensation and Indemnification of Trustee and Its Prior Claim |
22 |
Section 6.07 |
Right of Trustee to Rely on Officer’s Certificate, Etc. |
22 |
Section 6.08 |
Disqualification; Conflicting Interests |
22 |
Section 6.09 |
Persons Eligible for Appointment as Trustee |
22 |
Section 6.10 |
Resignation and Removal; Appointment of Successor Trustee |
22 |
Section 6.11 |
Acceptance of Appointment by Successor Trustee |
23 |
Section 6.12 |
Merger, Conversion, Consolidation or Succession to Business of Trustee |
24 |
Section 6.13 |
Preferential Collection of Claims Against the Issuer |
24 |
ARTICLE 7 |
CONCERNING THE SECURITYHOLDERS |
24 |
Section 7.01 |
Evidence of Action Taken by Securityholders |
24 |
Section 7.02 |
Proof of Execution of Instruments and of Holding of Securities |
24 |
Section 7.03 |
Holders to Be Treated as Owners |
25 |
Section 7.04 |
Securities Owned by Issuer Deemed Not Outstanding |
25 |
Section 7.05 |
Right of Revocation of Action Taken |
25 |
ARTICLE 8 |
SUPPLEMENTAL INDENTURES |
25 |
Section 8.01 |
Supplemental Indentures Without Consent of Securityholders |
25 |
Section 8.02 |
Supplemental Indentures With Consent of Securityholders |
27 |
Section 8.03 |
Effect of Supplemental Indenture |
27 |
Section 8.04 |
Documents to Be Given to Trustee |
28 |
Section 8.05 |
Notation on Securities in Respect of Supplemental Indentures |
28 |
ARTICLE 9 |
CONSOLIDATION, MERGER, SALE OR CONVEYANCE |
28 |
Section 9.01 |
Issuer May Consolidate, Etc., on Certain Terms |
28 |
Section 9.02 |
Successor Issuer Substituted |
28 |
ARTICLE 10 |
SATISFACTION AND DISCHARGE OF INDENTURE; DEFEASANCE; UNCLAIMED MONEYS |
29 |
Section 10.01 |
Satisfaction and Discharge of Indenture; Defeasance |
29 |
Section 10.02 |
Application by Trustee of Funds Deposited for Payment of Securities |
31 |
Section 10.03 |
Repayment of Moneys Held by Paying Agent |
31 |
Section 10.04 |
Return of Moneys Held by Trustee and Paying Agent Unclaimed for Two Years |
31 |
Section 10.05 |
Indemnity for U.S. Government Obligations |
31 |
ARTICLE 11 |
MISCELLANEOUS PROVISIONS |
32 |
Section 11.01 |
No Recourse |
32 |
Section 11.02 |
Provisions of Indenture for the Sole Benefit of Parties and Holders of Securities |
32 |
Section 11.03 |
Successors and Assigns of Issuer Bound by Indenture |
32 |
Section 11.04 |
Notices and Demands on Issuer, Trustee and Holders of Securities |
32 |
Section 11.05 |
Officer’s Certificates and Opinions of Counsel; Statements to Be Contained Therein |
33 |
Section 11.06 |
Payments Due on Saturdays, Sundays and Holidays |
34 |
Section 11.07 |
Conflict of Any Provision of Indenture With Trust Indenture Act of 1939 |
34 |
Section 11.08 |
New York Law to Govern |
34 |
Section 11.09 |
Counterparts |
34 |
Section 11.10 |
Effect of Headings |
34 |
Section 11.11 |
Actions by Successor |
34 |
Section 11.12 |
Severability |
34 |
ARTICLE 12 |
REDEMPTION OF SECURITIES AND SINKING FUNDS |
34 |
Section 12.01 |
Applicability of Article |
34 |
Section 12.02 |
Notice of Redemption; Partial Redemptions |
34 |
Section 12.03 |
Payment of Securities Called for Redemption |
35 |
Section 12.04 |
Exclusion of Certain Securities from Eligibility for Selection for Redemption |
36 |
Section 12.05 |
Mandatory and Optional Sinking Funds |
36 |
THIS INDENTURE, dated as of between Avenue Therapeutics, Inc.,
a Delaware corporation (the “Issuer”), and ____________, a ____________ (the “Trustee”),
W I T N E S S E T H :
WHEREAS, the Issuer may from time to time duly
authorize the issue of its senior debentures, notes or other evidences of indebtedness to be issued in one or more series (the “Securities”)
up to such principal amount or amounts as may from time to time be authorized in accordance with the terms of this Indenture;
WHEREAS, the Issuer has duly authorized the execution
and delivery of this Indenture to provide, among other things, for the authentication, delivery and administration of the Securities;
and
WHEREAS, all things necessary to make this Indenture
a valid indenture and agreement according to its terms have been done;
NOW, THEREFORE:
In consideration of the premises and the purchases
of the Securities by the holders thereof, the Issuer and the Trustee mutually covenant and agree for the equal and proportionate benefit
of the respective holders from time to time of the Securities as follows:
ARTICLE 1
DEFINITIONS
Section 1.01 Certain
Terms Defined. The following terms (except as otherwise expressly provided or unless the context otherwise clearly requires) for all
purposes of this Indenture and of any indenture supplemental hereto shall have the respective meanings specified in this Section. All
other terms used in this Indenture that are defined in the Trust Indenture Act of 1939 or the definitions of which in the Securities Act
of 1933, as amended, are referred to in the Trust Indenture Act of 1939, including terms defined therein by reference to the Securities
Act of 1933, as amended (except as herein otherwise expressly provided or unless the context otherwise clearly requires), shall have the
meanings assigned to such terms in said Trust Indenture Act of 1939 and in said Securities Act of 1933 as in force at the date of this
Indenture. All accounting terms used herein and not expressly defined shall have the meanings assigned to such terms in accordance with
generally accepted accounting principles, and the term “generally accepted accounting principles” means such accounting
principles as are generally accepted in the United States at the time of any computation. The words “herein”, “hereof”
and “hereunder” and other words of similar import refer to this Indenture as a whole and not to any particular Article, Section or
other subdivision. The terms defined in this Article have the meanings assigned to them in this Article and include the plural
as well as the singular.
“Additional Amounts” means any
additional amounts that are required by this Indenture or by any Security, under circumstances specified herein or therein, to be paid
by the Issuer in respect of certain taxes, assessments or other governmental charges imposed on Holders specified there and which are
owing to such Holders.
“Applicable Procedures” means,
with respect to a Depositary, as to any matter at any time, the policies and procedures of such Depositary, if any, that are applicable
to such matter at such time.
“Board of Directors” means either
the Board of Directors of the Issuer or any committee of such Board duly authorized to act on its behalf.
“Board Resolution” means a copy
of one or more resolutions, certified by the secretary or an assistant secretary of the Issuer to have been duly adopted by the Board
of Directors and to be in full force and effect, and delivered to the Trustee.
“Business Day” means, with respect
to any Security, a day that in the city (or in any of the cities, if more than one) in which amounts are payable, as specified in the
form of such Security, is not a day on which banking institutions are authorized or required by law or regulation to close.
“Capital Stock” means (a) in
the case of a corporation, corporate stock, (b) in the case of an association or business entity, any and all shares, interests,
participations, rights or other equivalents (however designated) of corporate stock, (c) in the case of a partnership or limited
liability company, partnership interests (whether general or limited) or membership interests, and (d) any other interest or participation
that confers on a Person the right to receive a share of the profits and losses of, or distributions of assets of, the issuing Person,
but excluding from all of the foregoing any Debt securities convertible into Capital Stock, whether or not such Debt securities include
any right of participation with Capital Stock.
“Commission” means the Securities
and Exchange Commission, as from time to time constituted, created under the Securities Exchange Act of 1934, or if at any time after
the execution and delivery of this Indenture such Commission is not existing and performing the duties now assigned to it under the Trust
Indenture Act of 1939, then the body performing such duties on such date.
“Common Stock” means the shares
of common stock, par value $0.0001 per share, of the Issuer as the same exists at the date of execution and delivery of this Indenture
or as such stock may be reconstituted from time to time.
“Corporate Trust Office” means
the office of the Trustee at which the corporate trust business of the Trustee shall, at any particular time, be principally administered,
which office is, at the date as of which this Indenture is dated, located at ___________________.
“Debt” of any Person means any
debt for money borrowed which is created, assumed, incurred or guaranteed in any manner by such Person or for which such Person is otherwise
responsible or liable, and shall expressly include any such guaranty thereof by such Person. For the purpose of computing the amount of
the Debt of any Person there shall be excluded all Debt of such Person for the payment or redemption or satisfaction of which money or
securities (or evidences of such Debt, if permitted under the terms of the instrument creating such Debt) in the necessary amount shall
have been deposited in trust with the proper depositary, whether upon or prior to the maturity or the date fixed for redemption of such
Debt; and, in any instance where Debt is so excluded, for the purpose of computing the assets of such Person there shall be excluded the
money, securities or evidences of Debt deposited by such Person in trust for the purpose of paying or satisfying such Debt.
“Depositary” means, with respect
to the Securities of any series issuable or issued in the form of one or more Global Securities, the Person designated as Depositary by
the Issuer pursuant to Section 2.04 until a successor Depositary shall have become such pursuant to the applicable provisions of
this Indenture, and thereafter “Depositary” shall mean or include each Person who is then a Depositary hereunder, and
if at any time there is more than one such Person, “Depositary” as used with respect to the Securities of any such
series shall mean the Depositary with respect to the Global Securities of that series.
“Dollar” means the currency
of the United States of America as at the time of payment is legal tender for the payment of public and private debts.
“Event of Default” means any
event or condition specified as such in Section 5.01.
“Foreign Currency” means a currency
issued by the government of a country other than the United States.
“Global Security” means a Security
evidencing all or a part of a series of Securities, issued to the Depositary for such series in accordance with Section 2.04, and
bearing the legend prescribed in Section 2.04.
“Holder”, “holder”,
“holder of Securities”, “Securityholder” or other similar terms mean the Person in whose name such
Security is registered in the Security register kept by the Issuer for that purpose in accordance with the terms hereof.
“Indenture” means this instrument
as originally executed and delivered or, if amended or supplemented as herein provided, as so amended or supplemented or both, and shall
include the forms and terms of particular series of Securities established as contemplated hereunder.
“interest”, unless the context
otherwise requires, refers to interest, and when used with respect to non-interest bearing Securities, refers to interest payable after
maturity, if any.
“Issuer” means Avenue Therapeutics, Inc.,
a Delaware corporation, and, subject to Article 9, its successors and assigns.
“Issuer Order” means a written
statement, request or order of the Issuer signed in its name by the chairman of the Board of Directors, the president or any vice president
of the Issuer.
“Notice
of Default” shall have the meaning set forth in Section 5.01(c).
“Officer’s Certificate”
means a certificate signed by the chairman of the Board of Directors, the president, any vice president, the treasurer, the secretary
or any assistant secretary of the Issuer and delivered to the Trustee. Each such certificate shall comply with Section 314 of the
Trust Indenture Act of 1939 and, except to the extent provided herein, shall include the statements provided for in Section 11.05.
“Opinion of Counsel” means an
opinion in writing signed by the general corporate counsel or such other legal counsel who may be an employee of or counsel to the Issuer
and who shall be satisfactory to the Trustee. Each such opinion shall comply with Section 314 of the Trust Indenture Act of 1939
and shall include the statements provided for in Section 11.05, if and to the extent required hereby.
“original issue date” of any
Security (or portion thereof) means the earlier of (a) the date of such Security or (b) the date of any Security (or portion
thereof) for which such Security was issued (directly or indirectly) on registration of transfer, exchange or substitution.
“Original Issue Discount Security”
means any Security that provides for an amount less than the principal amount thereof to be due and payable upon a declaration of acceleration
of the maturity thereof pursuant to Section 5.01.
“Outstanding”, when used with
reference to Securities, shall, subject to the provisions of Section 7.04, mean, as of any particular time, all Securities authenticated
and delivered by the Trustee under this Indenture, except
(i) Securities
theretofore cancelled by the Trustee or delivered to the Trustee for cancellation;
(ii) Securities,
or portions thereof, for the payment or redemption of which cash or U.S. Government Obligations (as provided for in Section 10.01
(a) and Section 10.01(b)) in the necessary amount shall have been deposited in trust with the Trustee or with any paying agent
(other than the Issuer) or shall have been set aside, segregated and held in trust by the Issuer for the Holders of such Securities (if
the Issuer shall act as its own paying agent); provided, that if such Securities, or portions thereof, are to be redeemed prior
to the maturity thereof, notice of such redemption shall have been given as herein provided, or provision satisfactory to the Trustee
shall have been made for giving such notice;
(iii) Securities
as to which Legal Defeasance shall have been effected pursuant to Section 10.01(b);
(iv) Securities
in substitution for which other Securities shall have been authenticated and delivered, or which shall have been paid, pursuant to the
terms of Section 2.09 (except with respect to any such Security as to which proof satisfactory to the Trustee is presented that such
Security is held by a Person in whose hands such Security is a legal, valid and binding obligation of the Issuer), Securities converted
into Common Stock or any other securities of the Company pursuant hereto and Securities not deemed outstanding pursuant to Section 12.02;
and
(v) Securities
as to which any property deliverable upon conversion thereof has been delivered (or such delivery has been made available), or as to which
any other particular conditions have been satisfied, in each case as may be provided for such Securities as contemplated in Section 2.03.
In determining whether the Holders of the requisite
principal amount of Outstanding Securities of any or all series have given any request, demand, authorization, direction, notice, consent
or waiver hereunder, (A) the principal amount of an Original Issue Discount Security that shall be deemed to be Outstanding for such
purposes shall be the amount of the principal thereof that would be due and payable as of the date of such determination upon a declaration
of acceleration of the maturity thereof pursuant to Section 5.01, (B) if, as of such date, the principal amount payable at the
Stated Maturity of a Security is not determinable, the principal amount of such Security which shall be deemed to be Outstanding shall
be the amount as specified or determined as contemplated by Section 2.03, and (C) the principal amount of a Security denominated
in one or more foreign currencies, composite currencies or currency units which shall be deemed to be Outstanding shall be the U.S. dollar
equivalent, determined as of such date in the manner provided as contemplated by Section 2.03, of the principal amount of such Security
(or, in the case of a Security described in clause (A) or (B) above, of the amount determined as provided in such clause).
“Person” means any individual,
corporation, partnership, limited partnership, limited liability company, joint venture, association, joint stock company, trust, unincorporated
organization or government or any agency or political subdivision thereof.
“principal” whenever used with
reference to the Securities or any Security or any portion thereof, shall be deemed to include “and premium, if any”.
“record
date” shall have the meaning set forth in Section 2.07.
“Responsible Officer”, when
used with respect to the Trustee, means the chairman of the board of directors, any vice chairman of the board of directors, the chairman
of the trust committee, the chairman of the executive committee, any vice chairman of the executive committee, the president, any vice
president, the cashier, the secretary, the treasurer, any trust officer, any assistant trust officer, any assistant vice president, any
assistant cashier, any assistant secretary, any assistant treasurer, or any other officer or assistant officer of the Trustee customarily
performing functions similar to those performed by the persons who at the time shall be such officers, respectively, or to whom any corporate
trust matter is referred because of his or her knowledge of and familiarity with the particular subject.
“Security” or “Securities”
has the meaning stated in the first recital of this Indenture, or, as the case may be, Securities that have been authenticated and delivered
under this Indenture.
“Security Registrar” shall have
the meaning set forth in Section 4.01(b).
“Subsidiary” means any corporation
or other entity (including, without limitation, partnerships, limited liability companies, joint ventures and associations) of which at
least a majority of the outstanding Capital Stock having by the terms thereof (without regard to the occurrence of any contingency) ordinary
voting power for the election of directors (or persons performing similar functions) of such corporation or other entity (irrespective
of whether or not at the time the Capital Stock of any other class or classes of such corporation or other entity shall have or might
have voting power by reason of the occurrence of any such contingency) is at the time directly or indirectly owned by the Issuer, or by
one or more Subsidiaries of the Issuer, or by the Issuer and one or more other Subsidiaries of the Issuer.
“Trust Indenture Act of 1939”
(except as otherwise provided in Sections 8.01 and 8.02) means the Trust Indenture Act of 1939 as in force at the date as of which this
Indenture was originally executed.
“Trustee” means the Person identified
as “Trustee” in the first paragraph hereof and, subject to the provisions of Article 6, shall also include any
successor trustee. “Trustee” shall also mean or include each Person who is then a trustee hereunder and if at any time
there is more than one such Person, “Trustee” as used with respect to the Securities of any series shall mean the trustee
with respect to the Securities of such series.
“U.S. Government Obligation”
means (a) a direct obligation of the United States of America, backed by its full faith and credit, or (b) an obligation of
a Person controlled or supervised by and acting as an agency or instrumentality of the United States of America, the payment of which
is unconditionally guaranteed as a full faith and credit obligation by the United States of America.
“vice president”, when used
with respect to the Issuer or the Trustee, means any vice president, whether or not designated by a number or a word or words added before
or after the title of “vice president”.
“Yield to Maturity” means the
yield to maturity on a series of securities, calculated at the time of issuance of such series, or, if applicable, at the most recent
redetermination of interest on such series, and calculated in accordance with accepted financial practice.
ARTICLE 2
SECURITIES
Section 2.01 Forms
Generally. The Securities of each series shall be substantially in such form (not inconsistent with this Indenture) as shall be established
by or pursuant to one or more Board Resolutions (as set forth in a Board Resolution or, to the extent established pursuant to (rather
than set forth in) a Board Resolution, an Officer’s Certificate detailing such establishment) or in one or more indentures supplemental
hereto, in each case with such appropriate insertions, omissions, substitutions and other variations as are required or permitted by this
Indenture and may have imprinted or otherwise reproduced thereon such legend or legends or endorsements, not inconsistent with the provisions
of this Indenture, as may be required to comply with any law or with any rules or regulations pursuant thereto, or with any rules of
any securities exchange or to conform to general usage, all as may be determined by the officers executing such Securities as evidenced
by their execution of such Securities.
The definitive Securities shall be printed, lithographed
or engraved on steel engraved borders or may be produced in any other manner, all as determined by the officers executing such Securities
as evidenced by their execution of such Securities.
Section 2.02 Form of
Trustee’s Certificate of Authentication. The Trustee’s certificate of authentication on all Securities shall be in substantially
the following form:
This is one of the Securities of the series designated
herein and referred to in the within-mentioned Indenture.
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as Trustee |
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By: |
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Authorized Officer |
Section 2.03 Amount
Unlimited; Issuable in Series. The aggregate principal amount of Securities which may be authenticated and delivered under
this Indenture is unlimited.
The Securities may be issued in one or more series.
The terms of a series of Securities shall be established prior to the initial issuance thereof in or pursuant to one or more Board Resolutions,
or, to the extent established pursuant to (rather than set forth in) a Board Resolution, in an Officer’s Certificate detailing such
establishment and/or established in one or more indentures supplemental hereto. The terms of such series reflected in such Board Resolution,
Officer’s Certificate, or supplemental indenture may include the following or any additional or different terms:
(i) the
designation of the Securities of the series (which may be part of a series of Securities previously issued);
(ii) the
terms and conditions, if applicable, upon which conversion or exchange of the Securities into Common Stock or any other securities of
the Company will be effected, including the initial conversion or exchange price or rate and any adjustments thereto, the conversion or
exchange period and other provisions in addition to or in lieu of those described herein;
(iii) any
limit upon the aggregate principal amount of the Securities of the series that may be authenticated and delivered under this Indenture
(except for Securities authenticated and delivered upon registration of transfer of, or in exchange for, or in lieu of, other Securities
of the series pursuant to Section 2.08, 2.09, 2.11, 8.05 or 12.03);
(iv) if
other than Dollars, the Foreign Currency in which the Securities of that series are denominated;
(v) the
date or dates on which the principal of the Securities of the series is payable or the method used to determine those dates and the right,
if any, to extend such date or dates;
(vi) the
rate or rates at which the Securities of the series shall bear interest, if any, or the method by which such rate or rates shall be determined;
the record date or dates for the determination of holders to whom interest is payable; the date or dates from which such interest shall
accrue and on which such interest shall be payable or the method by which such date or dates shall be determined; the right, if any, to
extend the interest payment periods and the duration of that extension; and the basis upon which interest shall be calculated if other
than that of a 360-day year of twelve 30-day months;
(vii) the
place or places where the principal of and any interest on Securities of the series shall be payable (if other than as provided in Section 3.02);
(viii) whether
or not the Securities will be secured or unsecured, and the terms of any secured debt;
(ix) the
price or prices at which, the period or periods within which and the terms and conditions upon which Securities of the series may be redeemed,
in whole or in part, at the option of the Issuer, pursuant to any sinking fund or otherwise;
(x) the
obligation, if any, of the Issuer to redeem, purchase or repay Securities of the series pursuant to any mandatory redemption, sinking
fund or analogous provisions or at the option of a Holder thereof and the price or prices at which and the period or periods within which
and any terms and conditions upon which Securities of the series shall be redeemed, purchased or repaid, in whole or in part, pursuant
to such obligation;
(xi) if
other than denominations of $1,000 and any integral multiple of $1,000 in excess thereof, the denominations in which Securities of the
series shall be issuable;
(xii) if
other than the principal amount thereof, the portion of the principal amount of Securities of the series which shall be payable upon declaration
of acceleration of the maturity thereof;
(xiii) if
other than the currency in which the Securities of that series are denominated, the currency in which payment of the principal of or interest
on the Securities of such series shall be payable;
(xiv) if
the principal of or interest on the Securities of the series is to be payable, at the election of the Issuer or a Holder thereof, in a
currency other than that in which the Securities are denominated, the period or periods within which, and the terms and conditions upon
which, such election may be made;
(xv) if
the amount of payments of principal of and interest on the Securities of the series may be determined with reference to an index based
on a currency other than that in which the Securities of the series are denominated, or by reference to one or more currency exchange
rates, securities or baskets of securities, commodity prices or indices, the manner in which such amounts shall be determined;
(xvi) if
Sections 10.01(b) or 10.01(c) are inapplicable to Securities of such series;
(xvii) whether
and under what circumstances the Issuer will pay Additional Amounts on the Securities of any series and, if so, whether the Issuer will
have the option to redeem such Securities rather than pay such Additional Amounts;
(xviii) if
the Securities of such series are to be issuable in definitive form (whether upon original issue or upon exchange of a temporary Security
of such series) only upon receipt of certain certificates or other documents or satisfaction of other conditions, then the form and terms
of such certificates, documents or conditions;
(xix) any
trustees, authenticating or paying agents, transfer agents or registrars or any other agents with respect to the Securities of such series;
(xx) any
other events of default or covenants with respect to the Securities of such series in addition to or in lieu of those contained in this
Indenture;
(xxi) if
the Securities of the series may be issued in exchange for surrendered Securities of another series, or for other securities of the Issuer,
pursuant to the terms of such Securities or securities or of any agreement entered into by the Issuer, the ratio of the principal amount
of the Securities of the series to be issued to the principal amount of the Securities or securities to be surrendered in exchange, and
any other material terms of the exchange; and
(xxii) any
other terms of the series.
The Issuer may from time to time, without notice
to or the consent of the holders of any series of Securities, create and issue further Securities of any such series ranking equally
with the Securities of such series in all respects (or in all respects other than (1) the payment of interest accruing prior to
the issue date of such further Securities or (2) the first payment of interest following the issue date of such further Securities).
Such further Securities may be consolidated and form a single series with the Securities of such series and have the same terms as to
status, redemption or otherwise as the Securities of such series.
Section 2.04 Authentication
and Delivery of Securities. The Issuer may deliver Securities of any series executed by the Issuer to the Trustee for authentication
together with the applicable documents referred to below in this Section, and the Trustee shall thereupon authenticate and deliver such
Securities to or upon the order of the Issuer (contained in the Issuer Order referred to below in this Section) or pursuant to such procedures
acceptable to the Trustee and to such recipients as may be specified from time to time by an Issuer Order. The maturity date, original
issue date, interest rate and any other terms of the Securities of such series shall be determined by or pursuant to such Issuer Order
and procedures. If provided for in such procedures, such Issuer Order may authorize authentication and delivery pursuant to oral instructions
from the Issuer or its duly authorized agent, which instructions shall be promptly confirmed in writing. In authenticating such Securities
and accepting the additional responsibilities under this Indenture in relation to such Securities, the Trustee shall be entitled to receive,
and (subject to Section 6.01) shall be fully protected in relying upon:
(i) an
Issuer Order requesting such authentication and setting forth delivery instructions if the Securities are not to be delivered to the Issuer;
(ii) any
Board Resolution, Officer’s Certificate and/or executed supplemental indenture referred to in Sections 2.01 and 2.03 by or pursuant
to which the forms and terms of the Securities were established;
(iii) an
Officer’s Certificate setting forth the form or forms and terms of the Securities stating that the form or forms and terms of the
Securities have been established pursuant to Sections 2.01 and 2.03 and comply with this Indenture, and covering such other matters as
the Trustee may reasonably request; and
(iv) an
Opinion of Counsel to the effect that:
(i) the
form or forms and terms of such Securities have been established pursuant to Sections 2.01 and 2.03 and comply with this Indenture,
(ii) the
authentication and delivery of such Securities by the Trustee are authorized under the provisions of this Indenture, and
(iii) such
Securities when authenticated and delivered by the Trustee and issued by the Issuer in the manner and subject to any conditions specified
in such Opinion of Counsel, will constitute valid and binding obligations of the Issuer.
The Trustee shall have the right to decline to
authenticate and deliver any Securities under this Section if the Trustee, being advised by counsel, determines that such action
may not lawfully be taken by the Issuer or if the Trustee in good faith by its board of directors or board of trustees, executive committee,
or a trust committee of directors or trustees or Responsible Officers shall determine that such action would expose the Trustee to personal
liability to existing Holders or would affect the Trustee’s own rights, duties or immunities under the Securities, this Indenture
or otherwise.
The Issuer shall execute and the Trustee shall,
in accordance with this Section with respect to the Securities of a series, authenticate and deliver one or more Global Securities
that (i) shall represent and shall be denominated in an amount equal to the aggregate principal amount of all of the Securities of
such series issued and not yet cancelled, (ii) shall be registered in the name of the Depositary for such Global Security or Securities
or the nominee of such Depositary, (iii) shall be delivered by the Trustee to such Depositary or pursuant to such Depositary’s
instructions and (iv) shall bear a legend substantially to the following effect:
“UNLESS AND UNTIL IT IS EXCHANGED IN WHOLE
OR IN PART FOR SECURITIES IN DEFINITIVE REGISTERED FORM, THIS SECURITY MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE DEPOSITARY
TO A NOMINEE OF THE DEPOSITARY OR BY A NOMINEE OF THE DEPOSITARY TO THE DEPOSITARY OR ANOTHER NOMINEE OF THE DEPOSITARY OR BY THE DEPOSITARY
OR ANY SUCH NOMINEE TO A SUCCESSOR DEPOSITARY OR A NOMINEE OF SUCH SUCCESSOR DEPOSITARY.”
Each Depositary designated pursuant to this Section must,
at the time of its designation and at all times while it serves as Depositary, be a clearing agency registered under the Securities Exchange
Act of 1934, as amended, and any other applicable statute or regulation.
Section 2.05 Execution
of Securities. The Securities shall be signed on behalf of the Issuer by the chairman of its Board of Directors, any vice chairman
of its Board of Directors, its chief executive officer, its principal financial officer, its president, any vice president or its treasurer.
Such signatures may be the manual or facsimile signatures of the present or any future such officers. Typographical and other minor errors
or defects in any such reproduction of any such signature shall not affect the validity or enforceability of any Security that has been
duly authenticated and delivered by the Trustee.
In case any officer of the Issuer who shall have
signed any of the Securities shall cease to be such officer before the Security so signed shall be authenticated and delivered by the
Trustee or disposed of by the Issuer, such Security nevertheless may be authenticated and delivered or disposed of as though the person
who signed such Security had not ceased to be such officer of the Issuer; and any Security may be signed on behalf of the Issuer by such
persons as, at the actual date of the execution of such Security, shall be the proper officers of the Issuer, although at the date of
the execution and delivery of this Indenture any such person was not such an officer.
Section 2.06 Certificate
of Authentication. Only such Securities as shall bear thereon a certificate of authentication substantially in the form hereinbefore
recited, executed by the Trustee by the manual signature of one of its authorized officers, shall be entitled to the benefits of this
Indenture or be valid or obligatory for any purpose. The execution of such certificate by the Trustee upon any Security executed by the
Issuer shall be conclusive evidence that the Security so authenticated has been duly authenticated and delivered hereunder and that the
Holder is entitled to the benefits of this Indenture.
Section 2.07 Denomination
and Date of Securities; Payments of Interest. The Securities of each series shall be issuable in denominations established
as contemplated by Section 2.03 or, if not so established, in denominations of $1,000 and any integral multiple of $1,000 in excess
thereof. The Securities of each series shall be numbered, lettered or otherwise distinguished in such manner or in accordance with such
plan as the officers of the Issuer executing the same may determine with the approval of the Trustee, as evidenced by the execution and
authentication thereof. Unless otherwise indicated in a Board Resolution, Officer’s Certificate or supplemental indenture for a
particular series, interest will be calculated on the basis of a 360-day year of twelve 30-day months.
Each Security shall be dated the date of its authentication.
The Securities of each series shall bear interest, if any, from the date, and such interest shall be payable on the dates, established
as contemplated by Section 2.03.
The Person in whose name any Security of any series
is registered at the close of business on any record date applicable to a particular series with respect to any interest payment date
for such series shall be entitled to receive the interest, if any, payable on such interest payment date notwithstanding any transfer,
exchange or conversion of such Security subsequent to the record date and prior to such interest payment date, except if and to the extent
the Issuer shall default in the payment of the interest due on such interest payment date for such series, in which case such defaulted
interest shall be paid to the Persons in whose names Outstanding Securities for such series are registered at the close of business on
a subsequent record date (which shall be not less than five Business Days prior to the date of payment of such defaulted interest) established
by notice given by or on behalf of the Issuer to the Holders of Securities not less than 15 days preceding such subsequent record date.
The term “record date” as used with respect to any interest payment date (except a date for payment of defaulted interest)
for the Securities of any series shall mean the date specified as such in the terms of the Securities of such series established as contemplated
by Section 2.03, or, if no such date is so specified, if such interest payment date is the first day of a calendar month, the 15th
day of the immediately preceding calendar month or, if such interest payment date is the 15th day of a calendar month, the first day of
such calendar month, whether or not such record date is a Business Day.
Section 2.08 Registration,
Transfer and Exchange. The Issuer will keep at each office or agency to be maintained for the purpose as provided in Section 3.02
for each series of Securities a register or registers in which, subject to such reasonable regulations as it may prescribe, it will provide
for the registration of Securities of such series and the registration of transfer of Securities of such series. Such register shall be
in written form in the English language or in any other form capable of being converted into such form within a reasonable time. At all
reasonable times such register or registers shall be open for inspection by the Trustee.
Upon due presentation for registration of transfer
of any Security of any series at any such office or agency to be maintained for the purpose as provided in Section 3.02, the Issuer
shall execute and the Trustee shall authenticate and deliver in the name of the transferee or transferees a new Security or Securities
of the same series, maturity date, interest rate and original issue date in authorized denominations for a like aggregate principal amount.
At the option of the Holder thereof, Securities
of any series (except a Global Security) may be exchanged for a Security or Securities of such series having authorized denominations
and an equal aggregate principal amount, upon surrender of such Securities to be exchanged at the agency of the Issuer that shall be maintained
for such purpose in accordance with Section 3.02 and upon payment, if the Issuer shall so require, of the charges hereinafter provided.
Whenever any Securities are so surrendered for exchange, the Issuer shall execute, and the Trustee shall authenticate and deliver, the
Securities which the Holder making the exchange is entitled to receive. All Securities surrendered upon any exchange or transfer provided
for in this Indenture shall be promptly cancelled and disposed of by the Trustee and the Trustee will deliver a certificate of disposition
thereof to the Issuer.
All Securities presented for registration of transfer,
exchange, redemption or payment shall (if so required by the Issuer or the Trustee) be duly endorsed by, or be accompanied by a written
instrument or instruments of transfer in form satisfactory to the Issuer and the Trustee duly executed by, the Holder or his or her attorney
duly authorized in writing.
The Issuer may require payment of a sum sufficient
to cover any stamp or other tax or other governmental charge that may be imposed in connection with any exchange or registration of transfer
of Securities. No service charge shall be made for any such transaction.
The Issuer shall not be required to exchange or
register a transfer of (a) any Securities of any series for a period of 15 days immediately preceding the first delivery of notice
of redemption of Securities of such series to be redeemed or (b) any Securities selected, called or being called for redemption,
in whole or in part, except, in the case of any Security to be redeemed in part, the portion thereof not so to be redeemed.
Notwithstanding any other provision of this Section 2.08,
unless and until it is exchanged in whole or in part for Securities in definitive registered form, a Global Security representing all
or a portion of the Securities of a series may not be transferred except as a whole by the Depositary for such series to a nominee of
such Depositary or by a nominee of such Depositary to such Depositary or another nominee of such Depositary or by such Depositary or any
such nominee to a successor Depositary for such series or a nominee of such successor Depositary.
If at any time the Depositary for the Securities
of a series notifies the Issuer that it is unwilling or unable to continue as Depositary for the Securities of such series or if at any
time the Depositary for the Securities of a series shall no longer be eligible under Section 2.04, the Issuer shall appoint a successor
Depositary with respect to the Securities of such series. If a successor Depositary for the Securities of such series is not appointed
by the Issuer within 90 days after the Issuer receives such notice or becomes aware of such ineligibility, the Issuer’s determination
pursuant to Section 2.03 that the Securities of such series be represented by a Global Security shall no longer be effective and
the Issuer will execute, and the Trustee, upon receipt of an Officer’s Certificate for the authentication and delivery of definitive
Securities of such series, will authenticate and deliver, Securities of such series in definitive registered form, in any authorized denominations,
in an aggregate principal amount equal to the principal amount of the Global Security or Securities representing the Securities of such
series, in exchange for such Global Security or Securities.
The Issuer may at any time and in its sole discretion
determine that the Securities of any series issued in the form of one or more Global Securities shall no longer be represented by a Global
Security or Securities. In such event the Issuer will execute, and the Trustee, upon receipt of an Officer’s Certificate for the
authentication and delivery of definitive Securities of such series, will authenticate and deliver, Securities of such series in definitive
registered form, in any authorized denominations, in an aggregate principal amount equal to the principal amount of the Global Security
or Securities representing such series, in exchange for such Global Security or Securities.
The Depositary for such Global Security may surrender
such Global Security in exchange in whole or in part for Securities of the same series in definitive registered form in accordance with
the two preceding paragraphs or on such other terms as are acceptable to the Issuer and such Depositary. Thereupon, the Issuer shall execute,
and the Trustee shall authenticate and deliver, without service charge,
(i) to
the Person specified by such Depositary a new Security or Securities of the same series, of any authorized denominations as requested
by such Person, in an aggregate principal amount equal to and in exchange for such Person’s beneficial interest in the Global Security;
and
(ii) to
such Depositary a new Global Security in a denomination equal to the difference, if any, between the principal amount of the surrendered
Global Security and the aggregate principal amount of Securities authenticated and delivered pursuant to clause (i) above.
Upon the exchange of a Global Security for Securities
in definitive registered form, in authorized denominations, such Global Security shall be cancelled by the Trustee. Securities in definitive
registered form issued in exchange for a Global Security pursuant to this Section 2.08 shall be registered in such names and in such
authorized denominations as the Depositary for such Global Security, pursuant to instructions from its direct or indirect participants
or otherwise, shall instruct the Trustee. The Trustee shall deliver such Securities to or as directed by the Persons in whose names such
Securities are so registered.
All Securities issued upon any transfer or exchange
of Securities shall be valid obligations of the Issuer, evidencing the same debt, and entitled to the same benefits under this Indenture,
as the Securities surrendered upon such transfer or exchange.
Section 2.09 Mutilated,
Defaced, Destroyed, Lost and Stolen Securities. In case any temporary or definitive Security shall become mutilated or defaced or
be destroyed, lost or stolen, the Issuer in its discretion may execute, and upon the written request of any officer of the Issuer, the
Trustee shall authenticate and deliver, a new Security of the same series, maturity date, interest rate and original issue date, bearing
a number or other distinguishing symbol not contemporaneously outstanding, in exchange and substitution for the mutilated or defaced Security,
or in lieu of and substitution for the Security so destroyed, lost or stolen. In every case the applicant for a substitute Security shall
furnish to the Issuer and to the Trustee and any agent of the Issuer or the Trustee such security or indemnity as may be required by them
to indemnify and defend and to save each of them harmless and, in every case of destruction, loss or theft, evidence to their satisfaction
of the destruction, loss or theft of such Security and of the ownership thereof and in the case of mutilation or defacement shall surrender
the Security to the Trustee.
Upon the issuance of any substitute Security, the
Issuer may require the payment of a sum sufficient to cover any tax or other governmental charge that may be imposed in relation thereto
and any other expenses (including the fees and expenses of the Trustee) connected therewith. In case any Security which has matured or
is about to mature or has been called for redemption in full, or is being surrendered for conversion in full, shall become mutilated or
defaced or be destroyed, lost or stolen, the Issuer may, instead of issuing a substitute Security (with the Holder’s consent, in
the case of convertible Securities), pay or authorize the payment of the same or convert, or authorize conversion of the same (without
surrender thereof except in the case of a mutilated or defaced Security), if the applicant for such payment shall furnish to the Issuer
and to the Trustee and any agent of the Issuer or the Trustee such security or indemnity as any of them may require to save each of them
harmless, and, in every case of destruction, loss or theft, the applicant shall also furnish to the Issuer and the Trustee and any agent
of the Issuer or the Trustee evidence to their satisfaction of the destruction, loss or theft of such Security and of the ownership thereof.
Every substitute Security of any series issued
pursuant to the provisions of this Section by virtue of the fact that any such Security is destroyed, lost or stolen shall constitute
an additional contractual obligation of the Issuer, whether or not the destroyed, lost or stolen Security shall be at any time enforceable
by anyone and shall be entitled to all the benefits of (but shall be subject to all the limitations of rights set forth in) this Indenture
equally and proportionately with any and all other Securities of such series duly authenticated and delivered hereunder. All Securities
shall be held and owned upon the express condition that, to the extent permitted by law, the foregoing provisions are exclusive with respect
to the replacement or payment or conversion of mutilated, defaced or destroyed, lost or stolen Securities and shall preclude any and all
other rights or remedies notwithstanding any law or statute existing or hereafter enacted to the contrary with respect to the replacement
or payment of negotiable instruments or other securities without their surrender.
Section 2.10 Cancellation
of Securities; Destruction Thereof. All Securities surrendered for exchange for Securities of the same series or for payment, redemption,
registration of transfer or conversion or for credit against any payment in respect of a sinking or analogous fund, if surrendered to
the Issuer or any agent of the Issuer or the Trustee, shall be delivered to the Trustee for cancellation or, if surrendered to the Trustee,
shall be cancelled by it; and no Securities shall be issued in lieu thereof except as expressly permitted by any of the provisions of
this Indenture. The Trustee shall dispose of cancelled Securities held by it and deliver a certificate of disposition to the Issuer. If
the Issuer shall acquire any of the Securities, such acquisition shall not operate as a redemption or satisfaction of the Debt represented
by such Securities unless and until the same are delivered to the Trustee for cancellation.
Section 2.11 Temporary
Securities. Pending the preparation of definitive Securities for any series, the Issuer may execute and the Trustee shall authenticate
and deliver temporary Securities for such series (printed, lithographed, typewritten or otherwise reproduced, in each case in form satisfactory
to the Trustee). Temporary Securities of any series shall be issuable in any authorized denomination, and substantially in the form of
the definitive Securities of such series but with such omissions, insertions and variations as may be appropriate for temporary Securities,
all as may be determined by the Issuer with the concurrence of the Trustee as evidenced by the execution and authentication thereof. Temporary
Securities may contain such reference to any provisions of this Indenture as may be appropriate. Every temporary Security shall be executed
by the Issuer and be authenticated by the Trustee upon the same conditions and in substantially the same manner, and with like effect,
as the definitive Securities. Without unreasonable delay the Issuer shall execute and shall furnish definitive Securities of such series
and thereupon temporary Securities of such series may be surrendered in exchange therefor without charge at each office or agency to be
maintained by the Issuer for that purpose pursuant to Section 3.02 and the Trustee shall authenticate and deliver in exchange for
such temporary Securities of such series an equal aggregate principal amount of definitive Securities of the same series having authorized
denominations. Until so exchanged, the temporary Securities of any series shall be entitled to the same benefits under this Indenture
as definitive Securities of such series, unless the benefits of the temporary Securities are limited pursuant to Section 2.03.
Section 2.12 CUSIP
Numbers. The Issuer in issuing the Securities may use “CUSIP” numbers if then generally in use and, if so, the Trustee
may use “CUSIP” numbers in notices of redemption as a convenience to Holders. Any such notice may state that no representation
is made as to the correctness of such numbers either as printed on the Securities or as contained in any notice of a redemption and that
reliance may be placed only on the other identification numbers printed on the Securities. No such redemption shall be affected by any
defect in or omission of such numbers.
ARTICLE 3
COVENANTS
OF THE ISSUER
Section 3.01 Payment
of Principal and Interest. The Issuer covenants and agrees for the benefit of each series of Securities that it will duly and punctually
pay or cause to be paid the principal of, and interest on, each of the Securities of such series (together with any Additional Amounts
payable pursuant to the terms of such Securities) at the place or places, at the respective times and in the manner provided in such Securities
and in this Indenture. The interest on Securities (together with any Additional Amounts payable pursuant to the terms of such Securities)
shall be payable only to or upon the written order of the Holders thereof and at the option of the Issuer may be paid by mailing checks
for such interest payable to or upon the written order of such Holders at their last addresses as they appear on the Security register
of the Issuer.
Section 3.02 Offices
for Payments, Etc. The Issuer will maintain (i) in ____________, an agency where the Securities of each series may be presented
for payment, an agency where the Securities of each series may be presented for exchange and conversion, if applicable, as provided in
this Indenture and an agency where the Securities of each series may be presented for registration of transfer as in this Indenture provided
and (ii) such further agencies in such places as may be determined for the Securities of such series pursuant to Section 2.03.
The Issuer will maintain in ____________ an agency
where notices and demands to or upon the Issuer in respect of the Securities of any series or this Indenture may be served.
The Issuer will give to the Trustee written notice
of the location of each such agency and of any change of location thereof. In case the Issuer shall fail to maintain any agency required
by this Section to be located in ____________, or shall fail to give such notice of the location or of any change in the location
of any of the above agencies, presentations and demands may be made and notices may be served at the Corporate Trust Office of the Trustee.
The Issuer may from time to time designate one
or more additional agencies where the Securities of a series may be presented for payment, where the Securities of that series may be
presented for exchange or conversion, if applicable, as provided in this Indenture and pursuant to Section 2.03 and where the Securities
of that series may be presented for registration of transfer as in this Indenture provided, and the Issuer may from time to time rescind
any such designation, as the Issuer may deem desirable or expedient; provided, however, that no such designation or rescission
shall in any manner relieve the Issuer of its obligation to maintain the agencies provided for in this Section. The Issuer will give to
the Trustee prompt written notice of any such designation or rescission thereof.
Section 3.03 Appointment
to Fill a Vacancy in Office of Trustee. The Issuer, whenever necessary to avoid or fill a vacancy in the office of Trustee, will appoint,
in the manner provided in Section 6.10, a Trustee, so that there shall at all times be a Trustee with respect to each series of Securities
hereunder.
Section 3.04 Paying
Agents. Whenever the Issuer shall appoint a paying agent other than the Trustee with respect to the Securities of any series, it will
cause such paying agent to execute and deliver to the Trustee an instrument in which such agent shall agree with the Trustee, subject
to the provisions of this Section,
(i) that
it will hold all sums received by it as such agent for the payment of the principal of or interest on the Securities of such series (whether
such sums have been paid to it by the Issuer or by any other obligor on the Securities of such series) in trust for the benefit of the
Holders of the Securities of such series or of the Trustee,
(ii) that
it will give the Trustee notice of any failure by the Issuer (or by any other obligor on the Securities of such series) to make any payment
of the principal of or interest on the Securities of such series when the same shall be due and payable, and
(iii) that
at any time during the continuance of any such failure, upon the written request of the Trustee, it will forthwith pay to the Trustee
all sums so held in trust by such paying agent.
The Issuer will, on or prior to each due date of
the principal of or interest on the Securities of such series, deposit with the paying agent a sum sufficient to pay such principal or
interest so becoming due, and (unless such paying agent is the Trustee) the Issuer will promptly notify the Trustee of any failure to
take such action.
If the Issuer shall act as its own paying agent
with respect to the Securities of any series, it will, on or before each due date of the principal of or interest on the Securities of
such series, set aside, segregate and hold in trust for the benefit of the Holders of the Securities of such series a sum sufficient to
pay such principal or interest so becoming due. The Issuer will promptly notify the Trustee of any failure to take such action.
Anything in this Section to the contrary notwithstanding,
but subject to Section 10.01, the Issuer may at any time, for the purpose of obtaining a satisfaction and discharge with respect
to one or more or all series of Securities hereunder, or for any other reason, pay or cause to be paid to the Trustee all sums held in
trust for any such series by the Issuer or any paying agent hereunder, as required by this Section, such sums to be held by the Trustee
upon the trusts herein contained.
Anything in this Section to the contrary notwithstanding,
the agreement to hold sums in trust as provided in this Section is subject to the provisions of Sections 10.03 and 10.04.
Section 3.05 Written
Statement to Trustee. So long as any Securities are Outstanding hereunder, the Issuer will deliver to the Trustee, within 120 days
after the end of each fiscal year of the Issuer ending after the date hereof, a written statement covering the previous fiscal year (which
need not comply with Section 11.05), signed by its principal executive officer, its principal financial officer or its principal
accounting officer, stating whether or not, to the best knowledge of such officer, the Issuer is in default in the performance and observance
of any of the terms, provisions and conditions of this Indenture (without regard to any period of grace or requirement of notice provided
hereunder), and, if the Issuer shall be in default, specifying all such defaults of which such officer may have knowledge and the nature
and status thereof.
ARTICLE 4
SECURITYHOLDERS
LISTS AND REPORTS BY THE ISSUER AND THE TRUSTEE
Section 4.01 Issuer
to Furnish Trustee Information as to Names and Addresses of Securityholders. The Issuer covenants and agrees that it will furnish
or cause to be furnished to the Trustee a list in such form as the Trustee may reasonably require of the names and addresses of the Holders
of the Securities of each series pursuant to Section 312 of the Trust Indenture Act of 1939:
(i) semiannually
and not more than 15 days after each record date for the payment of interest on such Securities, as hereinabove specified, as of such
record date and on dates to be determined pursuant to Section 2.03 for non-interest bearing Securities in each year, and
(ii) at
such other times as the Trustee may request in writing, within 30 days after receipt by the Issuer of any such request as of a date not
more than 15 days prior to the time such information is furnished, provided, that, if and so long as the Trustee shall be the Security
registrar (the “Security Registrar”) for such series, such list shall not be required to be furnished.
Section 4.02 Reports
by the Issuer. The Issuer covenants to comply with Section 314(a) of the Trust Indenture Act of 1939 insofar as it relates
to information, documentation, and other reports which the Issuer may be required to file with the Commission pursuant to Section 13
or Section 15(d) of the Securities Exchange Act of 1934, as amended.
Section 4.03 Reports
by the Trustee. Any Trustee’s report required under Section 313(a) of the Trust Indenture Act of 1939 shall be transmitted
on or before in each year following the date hereof, so long as any Securities are Outstanding hereunder, and shall be dated as of a date
convenient to the Trustee but no more than 60 nor less than 45 days prior thereto. The Trustee shall comply with Sections 313(b), 313(c) and
313(d) of the Trust Indenture Act of 1939.
Section 4.04 Preservation
of Information; Communication with Securityholders. (a) The Trustee shall preserve, in as current a form as is reasonably practicable,
all information as to the names and addresses of the holders of Securities contained in the most recent list furnished to it as provided
in Section 4.01 and as to the names and addresses of holders of Securities received by the Trustee in its capacity as Security Registrar
(if acting in such capacity).
(i) The
Trustee may destroy any list furnished to it as provided in Section 4.01 upon receipt of a new list so furnished.
(ii) Securityholders
may communicate as provided in Section 312(b) of the Trust Indenture Act of 1939 with other Securityholders with respect to
their rights under this Indenture or under the Securities. The Issuer, the Trustee, the Security Registrar and any other Person shall
have the protection of Section 312(c) of the Trust Indenture Act of 1939.
ARTICLE 5
REMEDIES
OF THE TRUSTEE AND SECURITYHOLDERS ON EVENT OF DEFAULT
Section 5.01 Event
of Default Defined; Acceleration of Maturity; Waiver of Default. “Event of Default”, with respect to Securities
of any series wherever used herein, means any one of the following events which shall have occurred and be continuing (whatever the reason
for such Event of Default and whether it shall be voluntary or involuntary or be effected by operation of law or pursuant to any judgment,
decree or order of any court or any order, rule or regulation of any administrative or governmental body):
(i) default
in the payment of any installment of interest upon any of the Securities of such series as and when the same shall become due and payable,
and continuance of such default for a period of 30 days (or such other period as may be established for the Securities of such series
as contemplated by Section 2.03); or
(ii) default
in the payment of all or any part of the principal on any of the Securities of such series as and when the same shall become due and payable
either at maturity, upon redemption, by declaration or otherwise (and, if established for the Securities of such series as contemplated
by Section 2.03, the continuance of such default for a specified period); or
(iii) default
in the performance, or breach, of any covenant or agreement of the Issuer in respect of the Securities of such series (other than a covenant
or agreement in respect of the Securities of such series a default in the performance or breach of which is elsewhere in this Section specifically
dealt with), and continuance of such default or breach for a period of 90 days after there has been given, by registered or certified
mail, to the Issuer by the Trustee or to the Issuer and the Trustee by the Holders of at least 25% in principal amount of the Outstanding
Securities of such series, a written notice specifying such default or breach and requiring it to be remedied and stating that such notice
is a “Notice of Default” hereunder; or
(iv) a
court having jurisdiction in the premises shall enter a decree or order for relief in respect of the Issuer in an involuntary case under
any applicable bankruptcy, insolvency or other similar law now or hereafter in effect, or appointing a receiver, liquidator, assignee,
custodian, trustee or sequestrator (or similar official) of the Issuer or for all or substantially all of its property and assets or ordering
the winding up or liquidation of its affairs, and such decree or order shall remain unstayed and in effect for a period of 90 consecutive
days; or
(v) the
Issuer shall commence a voluntary case under any applicable bankruptcy, insolvency or other similar law now or hereafter in effect, or
consent to the entry of an order for relief in an involuntary case under any such law, or consent to the appointment of or taking possession
by a receiver, liquidator, assignee, custodian, trustee or sequestrator (or similar official) of the Issuer or for any substantial part
of its property and assets, or make any general assignment for the benefit of creditors; or
(vi) any
other Event of Default provided for in such series of Securities.
If an Event of Default described in clauses (a),
(b), (c) or (f) occurs and is continuing, then, and in each and every such case, unless the principal of all of the Securities
of such series shall have already become due and payable, either the Trustee or the Holders of not less than 25% in aggregate principal
amount of the Securities of such series then Outstanding hereunder (each such series voting as a separate class) by notice in writing
to the Issuer (and also to the Trustee if given by Securityholders), may declare the entire principal (or, if the Securities of such series
are Original Issue Discount Securities, such portion of the principal amount as may be specified in the terms of such series) of all Securities
of such series and the interest accrued thereon, if any, to be due and payable immediately, and upon any such declaration the same shall
become immediately due and payable. If an Event of Default described in clauses (d) or (e) occurs and is continuing, then and
in each and every such case, the entire principal (or, if any Securities are Original Issue Discount Securities, such portion of the principal
as may be specified in the terms thereof) of all the Securities then Outstanding and interest accrued thereon, if any, shall automatically
become immediately due and payable.
The foregoing provisions, however, are subject
to the condition that if, at any time after the principal of the Securities of any series shall have been so declared due and payable,
and before any judgment or decree for the payment of the moneys due shall have been obtained or entered as hereinafter provided, the Issuer
shall pay or shall deposit with the Trustee a sum sufficient to pay all matured installments of interest upon all the Securities of such
series and the principal of any and all Securities of such series which shall have become due otherwise than by acceleration (with interest
upon such principal and, to the extent that payment of such interest is enforceable under applicable law, on overdue installments of interest,
at the same rate as the rate of interest specified in the Securities of such series to the date of such payment or deposit) and such amount
as shall be sufficient to cover reasonable compensation to the Trustee, its agents, attorneys and counsel, and all other expenses and
liabilities incurred, and all advances made, by the Trustee except as a result of negligence or bad faith, and if any and all Events of
Default under the Indenture with respect to such series, other than the non-payment of the principal of Securities of such series which
shall have become due solely by such acceleration, shall have been cured, waived or otherwise remedied as provided herein, then and in
every such case the Holders of a majority in aggregate principal amount of all the Securities of such series then Outstanding, by written
notice to the Issuer and to the Trustee, may waive all defaults with respect to such series and rescind and annul such declaration and
its consequences, but no such waiver or rescission and annulment shall extend to or shall affect any subsequent default or shall impair
any right consequent thereon.
Unless otherwise indicated in the Board Resolution,
Officer’s Certificate or supplemental indenture for a series of Original Issue Discount Securities, for all purposes under this
Indenture, if a portion of the principal of any Original Issue Discount Securities shall have been accelerated and declared due and payable
pursuant to the provisions hereof, then, from and after such declaration, unless such declaration has been rescinded and annulled, the
principal amount of such Original Issue Discount Securities shall be deemed, for all purposes hereunder, to be such portion of the principal
thereof as shall be due and payable as a result of such acceleration, and payment of such portion of the principal thereof as shall be
due and payable as a result of such acceleration, together with interest, if any, thereon and all other amounts owing thereunder, shall
constitute payment in full of such Original Issue Discount Securities.
Section 5.02 Collection
of Debt by Trustee; Trustee May Prove Debt. The Issuer covenants that (a) in case default shall be made in the payment of
any installment of interest on any of the Securities of any series when such interest shall have become due and payable, and such default
shall have continued for a period of 30 days or (b) in case default shall be made in the payment of all or any part of the principal
of any of the Securities of any series when the same shall have become due and payable, whether upon maturity of the Securities of such
series or upon any redemption or by declaration or otherwise—then, upon demand of the Trustee, the Issuer will pay to the Trustee
for the benefit of the Holders of the Securities of such series the whole amount that then shall have become due and payable on all Securities
of such series for principal or interest, as the case may be (with interest to the date of such payment upon the overdue principal and,
to the extent that payment of such interest is enforceable under applicable law, on overdue installments of interest at the same rate
as the rate of interest or Yield to Maturity (in the case of Original Issue Discount Securities) specified in the Securities of such series);
and, in addition thereto, such further amount as shall be sufficient to cover the costs and expenses of collection, including reasonable
compensation to the Trustee and each predecessor trustee, their respective agents, attorneys and counsel, and any expenses and liabilities
incurred, and all advances made, by the Trustee and each predecessor trustee except as a result of its negligence or bad faith.
In case the Issuer shall fail forthwith to pay
such amounts upon such demand, the Trustee, in its own name and as trustee of an express trust, shall be entitled and empowered to institute
any action or proceedings at law or in equity for the collection of the sums so due and unpaid, and may prosecute any such action or proceedings
to judgment or final decree, and may enforce any such judgment or final decree against the Issuer or other obligor upon such Securities
and collect in the manner provided by law out of the property of the Issuer or other obligor upon such Securities, wherever situated,
the moneys adjudged or decreed to be payable.
In case there shall be pending proceedings relative
to the Issuer or any other obligor upon the Securities under Title 11 of the United States Code or any other applicable Federal or state
bankruptcy, insolvency or other similar law, or in case a receiver, assignee or trustee in bankruptcy or reorganization, liquidator, sequestrator
or similar official shall have been appointed for or taken possession of the Issuer or its property or such other obligor or its property,
or in case of any other comparable judicial proceedings relative to the Issuer or other obligor upon the Securities of any series, or
to the creditors or property of the Issuer or such other obligor, the Trustee, irrespective of whether the principal of any Securities
shall then be due and payable as therein expressed or by declaration or otherwise and irrespective of whether the Trustee shall have made
any demand pursuant to the provisions of this Section, shall be entitled and empowered, by intervention in such proceedings or otherwise:
(i) to
file and prove a claim or claims for the whole amount of principal and interest (or, if the Securities of any series are Original Issue
Discount Securities, such portion of the principal amount as may be specified in the terms of such series) owing and unpaid in respect
of the Securities of any series, and to file such other papers or documents as may be necessary or advisable in order to have the claims
of the Trustee (including any claim for reasonable compensation to the Trustee and each predecessor trustee, and their respective agents,
attorneys and counsel, and for reimbursement of all expenses and liabilities incurred, and all advances made, by the Trustee and each
predecessor trustee, except as a result of negligence or bad faith) and of the Securityholders allowed in any judicial proceedings relative
to the Issuer or other obligor upon the Securities of any series, or to the creditors or property of the Issuer or such other obligor,
(ii) unless
prohibited by applicable law and regulations, to vote on behalf of the Holders of the Securities of any series in any election of a trustee
or a standby trustee in arrangement, reorganization, liquidation or other bankruptcy or insolvency proceedings or person performing similar
functions in comparable proceedings, and
(iii) to
collect and receive any moneys or other property payable or deliverable on any such claims, and to distribute all amounts received with
respect to the claims of the Securityholders and of the Trustee on their behalf; and any trustee, receiver or liquidator, custodian or
other similar official is hereby authorized by each of the Securityholders to make payments to the Trustee, and, in the event that the
Trustee shall consent to the making of payments directly to the Securityholders, to pay to the Trustee such amounts as shall be sufficient
to cover reasonable compensation to the Trustee, each predecessor trustee and their respective agents, attorneys and counsel, and all
other expenses and liabilities incurred, and all advances made, by the Trustee and each predecessor trustee except as a result of negligence
or bad faith and all other amounts due to the Trustee or any predecessor trustee pursuant to Section 6.06.
Nothing herein contained shall be deemed to authorize
the Trustee to authorize or consent to or vote for or accept or adopt on behalf of any Securityholder any plan of reorganization, arrangement,
adjustment or composition affecting the Securities of any series or the rights of any Holder thereof, or to authorize the Trustee to vote
in respect of the claim of any Securityholder in any such proceeding except, as aforesaid, to vote for the election of a trustee in bankruptcy
or similar person.
All rights of action and of asserting claims under
this Indenture, or under any of the Securities of any series, may be enforced by the Trustee without the possession of any of the Securities
of such series or the production thereof on any trial or other proceedings relative thereto, and any such action or proceedings instituted
by the Trustee shall be brought in its own name as trustee of an express trust, and any recovery of judgment, subject to the payment of
the expenses, disbursements and compensation of the Trustee, each predecessor trustee and their respective agents and attorneys, shall
be for the ratable benefit of the Holders of the Securities in respect of which such action was taken.
In any proceedings brought by the Trustee (and
also any proceedings involving the interpretation of any provision of this Indenture to which the Trustee shall be a party), the Trustee
shall be held to represent all the Holders of the Securities in respect to which such action was taken, and it shall not be necessary
to make any Holders of such Securities parties to any such proceedings.
Section 5.03 Application
of Proceeds. Any moneys collected by the Trustee pursuant to this Article in respect of any series shall be applied in the following
order at the date or dates fixed by the Trustee and, in case of the distribution of such moneys on account of principal or interest, upon
presentation of the several Securities in respect of which monies have been collected and stamping (or otherwise noting) thereon the payment,
or issuing Securities of such series in reduced principal amounts in exchange for the presented Securities of like series if only partially
paid, or upon surrender thereof if fully paid:
FIRST: To the payment of all amounts due to the
Trustee or any predecessor trustee pursuant to Section 6.06;
SECOND: In case the principal of the Securities
of such series in respect of which moneys have been collected shall not have become and be then due and payable, to the payment of interest
on the Securities of such series in default in the order of the maturity of the installments of such interest, with interest (to the extent
that such interest has been collected by the Trustee) upon the overdue installments of interest, to the extent permitted by applicable
law, at the same rate as the rate of interest or Yield to Maturity (in the case of Original Issue Discount Securities) specified in such
Securities, such payments to be made ratably to the Persons entitled thereto, without discrimination or preference;
THIRD: In case the principal of the Securities
of such series in respect of which moneys have been collected shall have become and shall be then due and payable, to the payment of the
whole amount then owing and unpaid upon all the Securities of such series for principal and interest, with interest upon the overdue principal,
and (to the extent that such interest has been collected by the Trustee) upon overdue installments of interest, to the extent permitted
by applicable law, at the same rate as the rate of interest or Yield to Maturity (in the case of Original Issue Discount Securities) specified
in the Securities of such series; and in case such moneys shall be insufficient to pay in full the whole amount so due and unpaid upon
the Securities of such series, then to the payment of such principal and interest, without preference or priority of principal over interest,
or of interest over principal, or of any installment of interest over any other installment of interest, or of any Security of such series
over any other Security of such series, ratably to the aggregate of such principal and accrued and unpaid interest; and
FOURTH: To the payment of the remainder, if any,
to the Issuer or any other Person lawfully entitled thereto.
Section 5.04 Suits
for Enforcement. In case an Event of Default has occurred, has not been waived and is continuing, the Trustee may in its discretion
proceed to protect and enforce the rights vested in it by this Indenture by such appropriate judicial proceedings as the Trustee shall
deem most effectual to protect and enforce any such rights, either at law or in equity or in bankruptcy or otherwise, whether for the
specific enforcement of any covenant or agreement contained in this Indenture or in aid of the exercise of any power granted in this Indenture
or to enforce any other legal or equitable right vested in the Trustee by this Indenture or by law.
Section 5.05 Restoration
of Rights on Abandonment of Proceedings. In case the Trustee shall have proceeded to enforce any right under this Indenture and such
proceedings shall have been discontinued or abandoned for any reason, or shall have been determined adversely to the Trustee, then and
in every such case (subject to any determination in such proceeding) the Issuer and the Trustee shall be restored respectively to their
former positions and rights hereunder, and all rights, remedies and powers of the Issuer, the Trustee and the Securityholders shall continue
as though no such proceedings had been taken.
Section 5.06 Limitations
on Suits by Securityholders. No Holder of any Security of any series shall have any right by virtue, or by availing itself, of any
provision of this Indenture to institute any action or proceeding at law or in equity or in bankruptcy or otherwise upon or under or with
respect to this Indenture, or for the appointment of a trustee, receiver, liquidator, custodian or other similar official or for any other
remedy hereunder, unless such Holder previously shall have given to the Trustee written notice of default and of the continuance thereof,
as hereinbefore provided, and unless also the Holders of not less than 25% in aggregate principal amount of the Securities of such series
then Outstanding shall have made written request upon the Trustee to institute such action or proceedings in its own name as trustee hereunder
and shall have offered to the Trustee such reasonable indemnity as it may require against the costs, expenses and liabilities to be incurred
therein or thereby and the Trustee for 60 days after its receipt of such notice, request and offer of indemnity shall have failed to institute
any such action or proceeding and no direction inconsistent with such written request shall have been given to the Trustee pursuant to
Section 5.09; it being understood and intended, and being expressly covenanted by the Holder of every Security of a particular series
with every other Holder of Securities of such series and the Trustee, that no one or more Holders of Securities of any series shall have
any right in any manner whatever by virtue or by availing of any provision of this Indenture to affect, disturb or prejudice the rights
of any other such Holder of Securities of such series, or to obtain or seek to obtain priority over or preference to any other such Holder
of such series or to enforce any right under this Indenture, except in the manner herein provided and for the equal, ratable and common
benefit of all Holders of Securities of the applicable series. For the protection and enforcement of the provisions of this Section, each
and every Securityholder and the Trustee shall be entitled to such relief as can be given either at law or in equity.
Section 5.07 Unconditional
Right of Securityholders to Institute Certain Suits. Notwithstanding any other provision in this Indenture and any provision of any
Security, the right of any Holder of any Security to receive payment of the principal of and interest on such Security on or after the
respective due dates expressed in such Security in accordance with the terms hereof and thereof, or to institute suit for the enforcement
of any such payment on or after such respective dates, shall not be impaired or affected without the consent of such Holder; it being
understood and intended, and being expressly covenanted by the Holder of every Security of a particular series with every other Holder
of Securities of such series and the Trustee, that no one or more Holders of Securities of any series shall have any right in any manner
whatever by virtue or by availing of any provision of this Indenture to affect, disturb or prejudice the rights of any other such Holder
of Securities of such series, or to obtain or seek to obtain priority over or preference to any other such Holder of Securities of such
series or to enforce any right under this Indenture, except in the manner herein provided and for the equal, ratable and common benefit
of all Holders of Securities of the applicable series. For the protection and enforcement of the provisions of this Section, each and
every Securityholder and the Trustee shall be entitled to such relief as can be given either at law or in equity.
Section 5.08 Powers
and Remedies Cumulative; Delay or Omission Not Waiver of Default. Except as provided in Section 5.06, no right or remedy herein
conferred upon or reserved to the Trustee or to the Holders of Securities is intended to be exclusive of any other right or remedy, and
every right and remedy shall, to the extent permitted by law, be cumulative and in addition to every other right and remedy given hereunder
or now or hereafter existing at law or in equity or otherwise. The assertion or employment of any right or remedy hereunder, or otherwise,
shall not prevent the concurrent assertion or employment of any other appropriate right or remedy.
No delay or omission of the Trustee or of any Holder
of Securities to exercise any right or power accruing upon any Event of Default occurring and continuing as aforesaid shall impair any
such right or power or shall be construed to be a waiver of any such Event of Default or an acquiescence therein; and, subject to Section 5.06,
every power and remedy given by this Indenture or by law to the Trustee or to the Holders of Securities may be exercised from time to
time, and as often as shall be deemed expedient, by the Trustee or by the Holders of Securities.
Section 5.09 Control
by Holders of Securities. The Holders of a majority in aggregate principal amount of the Securities of each series affected (with
each series voting as a separate class) at the time Outstanding shall have the right to direct the time, method and place of conducting
any proceeding for any remedy available to the Trustee, or exercising any trust or power conferred on the Trustee with respect to the
Securities of such series by this Indenture; provided, that such direction shall not be otherwise than in accordance with law and the
provisions of this Indenture and provided, further, that (subject to the provisions of Section 6.01) the Trustee shall have the right
to decline to follow any such direction if the Trustee, being advised by counsel, shall determine that the action or proceeding so directed
may not lawfully be taken or if the Trustee in good faith by its board of directors, the executive committee, or a trust committee of
directors or Responsible Officers of the Trustee shall determine that the action or proceedings so directed would involve the Trustee
in personal liability or if the Trustee in good faith shall so determine that the actions or forbearances specified in or pursuant to
such direction would be unduly prejudicial to the interests of Holders of the Securities of all series so affected not joining in the
giving of said direction, it being understood that (subject to Section 6.01) the Trustee shall have no duty to ascertain whether
or not such actions or forbearances are unduly prejudicial to such Holders.
Nothing in this Indenture shall impair the right
of the Trustee in its discretion to take any action deemed proper by the Trustee and which is not inconsistent with such direction or
directions by Securityholders.
Section 5.10 Waiver
of Past Defaults. The Holders of a majority in aggregate principal amount of the Securities of any series at the time Outstanding,
by notice to the Trustee, may on behalf of the Holders of all the Securities of such series waive any existing default in the performance
of any of the covenants contained herein or established pursuant to Section 2.03 with respect to such series and its consequences,
except an uncured default in the payment of the principal of, or interest on, any of the Securities of that series as and when the same
shall become due by the terms of such Securities; and may rescind an acceleration and its consequences, including any related payment
default that resulted from such acceleration. In the case of any such waiver, the Issuer, the Trustee and the Holders of the Securities
of such series shall be restored to their former positions and rights hereunder, respectively, such default shall cease to exist and be
deemed to have been cured and not to have occurred, and any Event of Default arising therefrom shall be deemed to have been cured, and
not to have occurred for every purpose of this Indenture; but no such waiver shall extend to any subsequent or other default or Event
of Default or impair any right consequent thereon.
Section 5.11 Trustee
to Give Notice of Default. The Trustee shall, within 90 days after the occurrence of a default with respect to the Securities of any
series, give notice of all defaults with respect to that series known to the Trustee to all Holders of Securities of such series in the
manner and to the extent provided in Sections 4.03 and 11.04, unless in each case such defaults shall have been cured before the giving
of such notice (the term “defaults” for the purpose of this Section being hereby defined to mean any event or
condition which is, or with notice or lapse of time or both would become, an Event of Default); provided, that, except in the case
of default in the payment of the principal of or interest on any of the Securities of such series, or in the payment of any sinking fund
installment on such series, the Trustee shall be protected in withholding such notice if and so long as the board of directors, the executive
committee, or a trust committee of directors or trustees and/or Responsible Officers of the Trustee in good faith determines that the
withholding of such notice is in the interests of the Securityholders of such series.
Section 5.12 Right
of Court to Require Filing of Undertaking to Pay Costs. All parties to this Indenture agree, and each Holder of any Security by his
or her acceptance thereof shall be deemed to have agreed, that any court may in its discretion require, in any suit for the enforcement
of any right or remedy under this Indenture or in any suit against the Trustee for any action taken, suffered or omitted by it as Trustee,
the filing by any party litigant in such suit of an undertaking to pay the costs of such suit, and that such court may in its discretion
assess reasonable costs, including reasonable attorneys’ fees, against any party litigant in such suit, having due regard to the
merits and good faith of the claims or defenses made by such party litigant; but the provisions of this Section shall not apply to
any suit instituted by the Trustee, to any suit instituted by any Securityholder or group of Securityholders of any series holding in
the aggregate more than 10% in aggregate principal amount of the Securities of such series, or to any suit instituted by any Securityholder
for the enforcement of the payment of the principal of or interest on any Security of such series, on or after the respective due dates
expressed in such Security or established pursuant to this Indenture.
ARTICLE 6
CONCERNING
THE TRUSTEE
Section 6.01 Duties
and Responsibilities of the Trustee; During Default; Prior to Default. With respect to the Holders of any series of Securities issued
hereunder, the Trustee, prior to the occurrence of an Event of Default with respect to the Securities of a particular series and after
the curing or waiving of all Events of Default which may have occurred with respect to such series, undertakes to perform such duties
and only such duties as are specifically set forth in this Indenture. In case an Event of Default with respect to the Securities of a
series has occurred (and has not been cured or waived), the Trustee shall exercise such of the rights and powers vested in it by this
Indenture, and use the same degree of care and skill in their exercise, as a prudent person would exercise or use under the circumstances
in the conduct of his or her own affairs.
No provision of this Indenture shall be construed
to relieve the Trustee from liability for its own negligent action, its own negligent failure to act or its own willful misconduct.
Section 6.02 Certain
Rights of the Trustee. In furtherance of and subject to the Trust Indenture Act of 1939 and subject to Section 6.01:
(i) in
the absence of bad faith on the part of the Trustee, the Trustee may conclusively rely, as to the truth of the statements and the correctness
of the opinions expressed therein, upon any statements, certificates or opinions furnished to the Trustee and conforming to the requirements
of this Indenture; but, in the case of any such statements, certificates or opinions which by any provision hereof are specifically required
to be furnished to the Trustee, the Trustee shall be under a duty to examine the same to determine whether or not they conform to the
requirements of this Indenture;
(ii) the
Trustee shall not be liable for any error of judgment made in good faith by a Responsible Officer or Responsible Officers of the Trustee,
unless it shall be proved that the Trustee was negligent in ascertaining the pertinent facts;
(iii) the
Trustee shall not be liable with respect to any action taken or omitted to be taken by it in good faith in accordance with the direction
of the Holders pursuant to Section 5.09 relating to the time, method and place of conducting any proceeding for any remedy available
to the Trustee, or exercising any trust or power conferred upon the Trustee, under this Indenture;
(iv) none
of the provisions contained in this Indenture shall require the Trustee to expend or risk its own funds or otherwise incur personal financial
liability in the performance of any of its duties or in the exercise of any of its rights or powers if there shall be reasonable ground
for believing that the repayment of such funds or adequate indemnity against such liability is not reasonably assured to it;
(v) the
Trustee may rely and shall be protected in acting or refraining from acting upon any resolution, Officer’s Certificate or any other
certificate, statement, instrument, opinion, report, notice, request, consent, order, bond, debenture, note, security or other paper or
document believed by it to be genuine and to have been signed or presented by the proper party or parties;
(vi) any
request, direction, order or demand of the Issuer mentioned herein shall be sufficiently evidenced by an Officer’s Certificate (unless
other evidence in respect thereof be herein specifically prescribed); and any resolution of the Board of Directors may be evidenced to
the Trustee by a copy thereof certified by the secretary or an assistant secretary of the Issuer;
(vii) the
Trustee may consult with counsel and any advice or Opinion of Counsel shall be full and complete authorization and protection in respect
of any action taken, suffered or omitted to be taken by it hereunder in good faith and in accordance with such advice or Opinion of Counsel;
(viii) the
Trustee shall be under no obligation to exercise any of the trusts or powers vested in it by this Indenture at the request, order or direction
of any of the Securityholders pursuant to the provisions of this Indenture, unless such Securityholders shall have offered to the Trustee
reasonable security or indemnity against the costs, expenses and liabilities that might be incurred therein or thereby;
(ix) the
Trustee shall not be liable for any action taken or omitted by it in good faith and believed by it to be authorized or within the discretion,
rights or powers conferred upon it by this Indenture;
(x) prior
to the occurrence of an Event of Default hereunder and after the curing or waiving of all Events of Default, the Trustee shall not be
bound to make any investigation into the facts or matters stated in any resolution, certificate, statement, instrument, opinion, report,
notice, request, consent, order, approval, appraisal, bond, debenture, note, security, or other paper or document unless requested in
writing so to do by the Holders of not less than a majority in aggregate principal amount of the Securities of all series affected then
Outstanding; provided, that, if the payment within a reasonable time to the Trustee of the costs, expenses or liabilities likely
to be incurred by it in the making of such investigation is, in the opinion of the Trustee, not reasonably assured to the Trustee by the
security afforded to it by the terms of this Indenture, the Trustee may require reasonable indemnity against such expenses or liabilities
as a condition to proceeding; the reasonable expenses of every such investigation shall be paid by the Issuer or, if paid by the Trustee
or any predecessor trustee, shall be repaid by the Issuer upon demand; and
(xi) the
Trustee may execute any of the trusts or powers hereunder or perform any duties hereunder either directly or by or through agents or attorneys
not regularly in its employ and the Trustee shall not be responsible for any misconduct or negligence on the part of any such agent or
attorney appointed with due care by it hereunder.
Section 6.03 Trustee
Not Responsible for Recitals, Disposition of Securities or Application of Proceeds Thereof. The recitals contained herein and in the
Securities, except the Trustee’s certificates of authentication, shall be taken as the statements of the Issuer, and the Trustee
assumes no responsibility for the correctness of the same. The Trustee makes no representation as to the validity or sufficiency of this
Indenture or of the Securities. The Trustee shall not be accountable for the use or application by the Issuer of any of the Securities
or of the proceeds thereof.
Section 6.04 Trustee
and Agents May Hold Securities; Collections, Etc. The Trustee or any agent of the Issuer or the Trustee, in its individual or
any other capacity, may become the owner or pledgee of Securities with the same rights it would have if it were not the Trustee or such
agent and may otherwise deal with the Issuer and receive, collect, hold and retain collections from the Issuer with the same rights it
would have if it were not the Trustee or such agent.
Section 6.05 Moneys
Held by Trustee. Subject to the provisions of Section 10.04 hereof, all moneys received by the Trustee shall, until used or applied
as herein provided, be held in trust for the purposes for which they were received, but need not be segregated from other funds except
to the extent required by mandatory provisions of law. Neither the Trustee nor any agent of the Issuer or the Trustee shall be under any
liability for interest on any moneys received by it hereunder.
Section 6.06 Compensation
and Indemnification of Trustee and Its Prior Claim. The Issuer covenants and agrees to pay to the Trustee from time to time, and the
Trustee shall be entitled to, such reasonable compensation (which shall not be limited by any provision of law in regard to the compensation
of a trustee of an express trust) as the Issuer and the Trustee may from time to time agree in writing and, except as otherwise expressly
provided herein, the Issuer covenants and agrees to pay or reimburse the Trustee and each predecessor trustee upon its request for all
reasonable expenses, disbursements and advances incurred or made by or on behalf of it in accordance with any of the provisions of this
Indenture (including the reasonable compensation and the expenses and disbursements of its counsel and of all agents and other persons
not regularly in its employ) except any such expense, disbursement or advance as may arise from its negligence or bad faith. The Issuer
also covenants to indemnify the Trustee and each predecessor trustee for, and to hold it harmless against, any loss, liability or expense
incurred without negligence or bad faith on its part, arising out of or in connection with the acceptance or administration of this Indenture
or the trusts hereunder and its duties hereunder, including the costs and expenses of defending itself against or investigating any claim
of liability in the premises. The obligations of the Issuer under this Section to compensate and indemnify the Trustee and each predecessor
trustee and to pay or reimburse the Trustee and each predecessor trustee for expenses, disbursements and advances shall constitute additional
indebtedness hereunder and shall survive the satisfaction and discharge of this Indenture. Such additional indebtedness shall be a senior
claim to that of the Securities upon all property and funds held or collected by the Trustee as such, except funds held in trust for the
benefit of the Holders of particular Securities, and the Securities are hereby subordinated to such senior claim.
Section 6.07 Right
of Trustee to Rely on Officer’s Certificate, Etc. Subject to Sections 6.01 and 6.02, whenever in the administration of the trusts
of this Indenture the Trustee shall deem it necessary or desirable that a matter be proved or established prior to taking or suffering
or omitting any action hereunder, such matter (unless other evidence in respect thereof be herein specifically prescribed) may, in the
absence of negligence or bad faith on the part of the Trustee, be deemed to be conclusively proved and established by an Officer’s
Certificate delivered to the Trustee, and such certificate, in the absence of negligence or bad faith on the part of the Trustee, shall
be full warrant to the Trustee for any action taken, suffered or omitted by it under the provisions of this Indenture upon the faith thereof.
Section 6.08 Disqualification;
Conflicting Interests. If the Trustee has or shall acquire any “conflicting interest” within the meaning of Section 310(b) of
the Trust Indenture Act of 1939, the Trustee and the Issuer shall in all respects comply with the provisions of Section 310(b) of
the Trust Indenture Act of 1939.
Section 6.09 Persons
Eligible for Appointment as Trustee. The Trustee for each series of Securities hereunder shall at all times be a corporation having
a combined capital and surplus of at least $50,000,000 and shall be eligible in accordance with the provisions of Section 310(a) of
the Trust Indenture Act of 1939. If such corporation publishes reports of condition at least annually, pursuant to law or to the requirements
of a Federal, State or District of Columbia supervising or examining authority, then, for the purposes of this Section, the combined capital
and surplus of such corporation shall be deemed to be its combined capital and surplus as set forth in its most recent report of condition
so published.
Section 6.10 Resignation
and Removal; Appointment of Successor Trustee. (a) The Trustee, or any trustee or trustees hereafter appointed, may at any time
resign with respect to one or more or all series of Securities by giving written notice of resignation to the Issuer and by delivering
notice of such resignation to the Holders of then Outstanding Securities of each series affected at their addresses as they shall appear
on the Security register. Upon receiving such notice of resignation, the Issuer shall promptly appoint a successor trustee or trustees
with respect to the applicable series by written instrument in duplicate, executed by authority of the Board of Directors, one copy of
which instrument shall be delivered to the resigning Trustee and one copy to the successor trustee or trustees. If no successor trustee
shall have been so appointed with respect to any series and have accepted appointment within 30 days after the delivery of such notice
of resignation, the resigning trustee may petition any court of competent jurisdiction for the appointment of a successor trustee, or
any Securityholder who has been a bona fide Holder of a Security or Securities of the applicable series for at least six months may,
on behalf of himself or herself and all others similarly situated, petition any such court for the appointment of a successor trustee.
Such court may thereupon, after such notice, if any, as it may deem proper and prescribe, appoint a successor trustee.
(i) In
case at any time any of the following shall occur:
(i) the
Trustee shall fail to comply with the provisions of Section 310(b) of the Trust Indenture Act of 1939 with respect to any series
of Securities after written request therefor by the Issuer or by any Securityholder who has been a bona fide Holder of a Security or Securities
of such series for at least six months; or
(ii) the
Trustee shall cease to be eligible in accordance with the provisions of Section 310(a) of the Trust Indenture Act of 1939 and
shall fail to resign after written request therefor by the Issuer or by any Securityholder; or
(iii) the
Trustee shall become incapable of acting with respect to any series of Securities, or shall be adjudged bankrupt or insolvent, or a receiver
or liquidator of the Trustee or of its property shall be appointed, or any public officer shall take charge or control of the Trustee
or of its property or affairs for the purpose of rehabilitation, conservation or liquidation; then, in any such case, (A) the Issuer
may remove the Trustee with respect to the applicable series of Securities and appoint a successor trustee for such series by written
instrument, in duplicate, executed by order of the Board of Directors, one copy of which instrument shall be delivered to the Trustee
so removed and one copy to the successor trustee, or, (B) subject to Section 315(e) of the Trust Indenture Act of 1939,
any Securityholder who has been a bona fide Holder of a Security or Securities of such series for at least six months may on behalf of
itself and all others similarly situated, petition any court of competent jurisdiction for the removal of the Trustee and the appointment
of a successor trustee with respect to such series. Such court may thereupon, after such notice, if any, as it may deem proper and prescribe,
remove the Trustee and appoint a successor trustee.
(ii) The
Holders of a majority in aggregate principal amount of the Securities of each series at the time Outstanding may at any time remove the
Trustee with respect to Securities of such series and, with the consent of the Issuer, appoint a successor trustee with respect to the
Securities of such series by delivering to the Trustee so removed, to the successor trustee so appointed and to the Issuer the evidence
provided for in Section 7.01 of the action in that regard taken by the Securityholders.
(iii) Any
resignation or removal of the Trustee with respect to any series and any appointment of a successor trustee with respect to such series
pursuant to any of the provisions of this Section 6.10 shall become effective upon acceptance of appointment by the successor trustee
as provided in Section 6.11.
Section 6.11 Acceptance
of Appointment by Successor Trustee. Any successor trustee appointed as provided in Section 6.10 shall execute and deliver to
the Issuer and to its predecessor trustee an instrument accepting such appointment hereunder, and thereupon the resignation or removal
of the predecessor trustee with respect to all or any applicable series shall become effective and such successor trustee, without any
further act, deed or conveyance, shall become vested with all rights, powers, duties and obligations with respect to such series of its
predecessor hereunder, with like effect as if originally named as trustee for such series hereunder; but, nevertheless, on the written
request of the Issuer or of the successor trustee, upon payment of its charges then unpaid, the trustee ceasing to act shall, subject
to Section 10.04, pay over to the successor trustee all moneys at the time held by it hereunder and shall execute and deliver an
instrument transferring to such successor trustee all such rights, powers, duties and obligations. Upon request of any such successor
trustee, the Issuer shall execute any and all instruments in writing for more fully and certainly vesting in and confirming to such successor
trustee all such rights and powers. Any trustee ceasing to act shall, nevertheless, retain a prior claim upon all property or funds held
or collected by such trustee to secure any amounts then due it pursuant to the provisions of Section 6.06.
If a successor trustee is appointed with respect
to the Securities of one or more (but not all) series, the Issuer, the predecessor trustee and each successor trustee with respect to
the Securities of any applicable series shall execute and deliver an indenture supplemental hereto which shall contain such provisions
as shall be deemed necessary or desirable to confirm that all the rights, powers, trusts and duties of the predecessor trustee with respect
to the Securities of any series as to which the predecessor trustee is not retiring shall continue to be vested in the predecessor trustee,
and shall add to or change any of the provisions of this Indenture as shall be necessary to provide for or facilitate the administration
of the trusts hereunder by more than one trustee, it being understood that nothing herein or in such supplemental indenture shall constitute
such trustees co-trustees of the same trust and that each such trustee shall be trustee of a trust or trusts under separate indentures.
No successor trustee with respect to any series
of Securities shall accept appointment as provided in this Section 6.11 unless at the time of such acceptance such successor trustee
shall be qualified under the provisions of Section 310(b) of the Trust Indenture Act of 1939 and eligible under the provisions
of Section 310(a) of the Trust Indenture Act of 1939.
Upon acceptance of appointment by any successor
trustee as provided in this Section 6.11, the Issuer shall deliver notice thereof to the Holders of Securities of each series affected,
by delivering such notice to such Holders at their addresses as they shall appear on the Security register. If the acceptance of appointment
is substantially contemporaneous with the resignation, then the notice called for by the preceding sentence may be combined with the notice
called for by Section 6.10. If the Issuer fails to deliver such notice within ten days after acceptance of appointment by the successor
trustee, the successor trustee shall cause such notice to be given at the expense of the Issuer.
Section 6.12 Merger,
Conversion, Consolidation or Succession to Business of Trustee. Any corporation into which the Trustee may be merged or converted
or with which it may be consolidated, or any corporation resulting from any merger, conversion or consolidation to which the Trustee shall
be a party, or any corporation succeeding to the corporate trust business of the Trustee, shall be the successor of the Trustee hereunder;
provided, that such corporation shall be qualified under the provisions of Section 310(b) of the Trust Indenture Act
of 1939 and eligible under the provisions of Section 310(a) of the Trust Indenture Act of 1939, without the execution or filing
of any paper or any further act on the part of any of the parties hereto, anything herein to the contrary notwithstanding.
In case, at the time such successor to the Trustee
shall succeed to the trusts created by this Indenture, any of the Securities of any series shall have been authenticated but not delivered,
any such successor to the Trustee may adopt the certificate of authentication of any predecessor trustee and deliver such Securities so
authenticated; and, in case at that time any of the Securities of any series shall not have been authenticated, any successor to the Trustee
may authenticate such Securities either in the name of any predecessor hereunder or in the name of the successor trustee; and in all such
cases such certificate shall have the full force which it is anywhere in the Securities of such series or in this Indenture provided that
the certificate of the Trustee shall have; provided, that the right to adopt the certificate of authentication of any predecessor
trustee or to authenticate Securities of any series in the name of any predecessor trustee shall apply only to its successor or successors
by merger, conversion or consolidation.
Section 6.13 Preferential
Collection of Claims Against the Issuer. The Trustee shall comply with Section 311(a) of the Trust Indenture Act of 1939,
excluding any creditor relationship described in Section 311(b) of the Trust Indenture Act of 1939. A Trustee who has resigned
or been removed shall be subject to Section 311(a) of the Trust Indenture Act of 1939 to the extent included therein.
ARTICLE 7
CONCERNING
THE SECURITYHOLDERS
Section 7.01 Evidence
of Action Taken by Securityholders. Any request, demand, authorization, direction, notice, consent, waiver or other action provided
by this Indenture to be given or taken by a specified percentage in principal amount of the Securityholders of any or all series may be
embodied in and evidenced by one or more instruments of substantially similar tenor signed by such specified percentage of Securityholders
in person or by agent duly appointed in writing; and, except as herein otherwise expressly provided, such action shall become effective
when such instrument or instruments are delivered to the Trustee. Proof of execution of any instrument or of a writing appointing any
such agent shall be sufficient for any purpose of this Indenture and (subject to Sections 6.01 and 6.02) conclusive in favor of the Trustee
and the Issuer, if made in the manner provided in this Article.
Section 7.02 Proof
of Execution of Instruments and of Holding of Securities. Subject to Sections 6.01 and 6.02, the execution of any instrument by a
Holder or his agent or proxy may be proved in accordance with such reasonable rules and regulations as may be prescribed by the Trustee
or in such manner as shall be satisfactory to the Trustee.
The holding of Securities shall be proved by the
Security register or by a certificate of the registrar thereof. The Issuer may set a record date for purposes of determining the identity
of Holders of any series entitled to vote or consent to any action referred to in Section 7.01, which record date may be set at any
time or from time to time by notice to the Trustee, for any date or dates (in the case of any adjournment or reconsideration) not more
than 60 days nor less than five days prior to the proposed date of such vote or consent, and thereafter, notwithstanding any other provisions
hereof, only Holders of such series of record on such record date shall be entitled to so vote or give such consent or revoke such vote
or consent. Notice of such record date may be given before or after any request for any action referred to in Section 7.01 is made
by the Issuer.
Section 7.03 Holders
to Be Treated as Owners. The Issuer, the Trustee and any agent of the Issuer or of the Trustee may deem and treat the Person in whose
name any Security shall be registered upon the Security register for such series as the absolute owner of such Security (whether or not
such Security shall be overdue and notwithstanding any notation of ownership or other writing thereon) for the purpose of receiving payment
of or on account of the principal of, and, subject to the provisions of this Indenture, interest on, such Security and for all other purposes;
and neither the Issuer nor the Trustee nor any agent of the Issuer or the Trustee shall be affected by any notice to the contrary. All
such payments so made to any such Person, or upon his or her order, shall be valid, and, to the extent of the sum or sums so paid, effectual
to satisfy and discharge the liability for moneys payable.
Section 7.04 Securities
Owned by Issuer Deemed Not Outstanding. In determining whether the Holders of the requisite aggregate principal amount of Outstanding
Securities of any or all series have concurred in any direction, consent or waiver under this Indenture, Securities that are owned by
the Issuer or any other obligor on the Securities with respect to which such determination is being made or by any Person directly or
indirectly controlling or controlled by or under direct or indirect common control with the Issuer or any other obligor on the Securities
with respect to which such determination is being made shall be disregarded and deemed not to be Outstanding for the purpose of any such
determination, except that, for the purpose of determining whether the Trustee shall be protected in relying on any such direction, consent
or waiver, only Securities which the Trustee knows are so owned shall be so disregarded. Securities so owned which have been pledged in
good faith may be regarded as Outstanding if the pledgee establishes to the satisfaction of the Trustee the pledgee’s right so to
act with respect to such Securities and that the pledgee is not the Issuer or any other obligor upon the Securities or any Person directly
or indirectly controlling or controlled by or under direct or indirect common control with the Issuer or any other obligor on the Securities.
In case of a dispute as to such right, the advice of counsel shall be full protection in respect of any decision made by the Trustee in
accordance with such advice.
Section 7.05 Right
of Revocation of Action Taken. At any time prior to (but not after) the evidencing to the Trustee, as provided in Section 7.01,
of the taking of any action by the Holders of the percentage in aggregate principal amount of the Securities of any or all series, as
the case may be, specified in this Indenture in connection with such action, any Holder of a Security the serial number of which is shown
by the evidence to be included among the serial numbers of the Securities the Holders of which have consented to such action may, by filing
written notice at the Corporate Trust Office and upon proof of holding as provided in this Article, revoke such action so far as concerns
such Security. Except as aforesaid, any such action taken by the Holder of any Security shall be conclusive and binding upon such Holder
and upon all future Holders and owners of such Security and of any Securities issued in exchange or substitution therefor or on registration
of transfer thereof, irrespective of whether or not any notation in regard thereto is made upon any such Security. Any action taken by
the Holders of the percentage in aggregate principal amount of the Securities of any or all series, as the case may be, specified in this
Indenture in connection with such action shall be conclusively binding upon the Issuer, the Trustee and the Holders of all the Securities
affected by such action.
ARTICLE 8
SUPPLEMENTAL
INDENTURES
Section 8.01 Supplemental
Indentures Without Consent of Securityholders. The Issuer, when authorized by a resolution of its Board of Directors, and the Trustee
may from time to time and at any time, without the consent of any of the Securityholders, enter into an indenture or indentures supplemental
hereto in form satisfactory to the Trustee for one or more of the following purposes:
(i) to
convey, transfer, assign, mortgage or pledge to the Trustee as security for the Securities of one or more series any property or assets;
(ii) to
evidence the succession of another Person to the Issuer, or successive successions, and the assumption by such successor of the covenants,
agreements and obligations of the Issuer pursuant to, or to otherwise comply with, Article 9;
(iii) to
comply with the requirements of the Commission in order to effect or maintain the qualification of this Indenture under the Trust Indenture
Act of 1939, as amended;
(iv) to
add to the covenants of the Issuer such further covenants, restrictions, conditions or provisions as its Board of Directors and the Trustee
shall consider to be for the protection of the Holders of Securities, and to make the occurrence, or the occurrence and continuance, of
a default in any such additional covenants, restrictions, conditions or provisions an Event of Default permitting the enforcement of all
or any of the several remedies provided in this Indenture as herein set forth; provided, that in respect of any such additional covenant,
restriction, condition or provision such supplemental indenture may provide for a particular period of grace after default (which period
may be shorter or longer than that allowed in the case of other defaults) or may provide for an immediate enforcement upon such an Event
of Default or may limit the remedies available to the Trustee upon such an Event of Default or may limit the right of the Holders of a
majority in aggregate principal amount of the Securities of such series to waive such an Event of Default;
(v) to
cure any ambiguity, defect or inconsistency, or to conform this Indenture or any supplemental indenture to the description of the Securities
set forth in any prospectus, prospectus supplement or offering memorandum related to such series of Securities;
(vi) to
provide for or add guarantors for the Securities of one or more series;
(vii) to
establish the form or terms of Securities of any series as permitted by Sections 2.01 and 2.03;
(viii) to
evidence and provide for the acceptance of appointment hereunder by a successor trustee with respect to the Securities of one or more
series and to add to or change any of the provisions of this Indenture as shall be necessary to provide for or facilitate the administration
of the trusts hereunder by more than one trustee, pursuant to the requirements of Section 6.11;
(ix) to
add to, change or eliminate any of the provisions of this Indenture in respect of one or more series of Securities, provided that any
such addition, change or elimination (i) shall not apply to any Securities issued prior to, and Outstanding as of the date of, the
execution of such supplemental indenture and entitled to the benefits of such provision or (ii) shall become effective only when
there are no Securities Outstanding hereunder;
(x) to
make any change to the Securities of any series so long as no Securities of such series are Outstanding; and
(xi) to
make any other change that does not adversely affect the interests of the Holders of the Securities in any material respect.
The Trustee shall join with the Issuer in the execution
of any such supplemental indenture, to make any further appropriate agreements and stipulations which may be therein contained and to
accept the conveyance, transfer, assignment, mortgage or pledge of any property thereunder, but the Trustee shall not be obligated to
enter into any such supplemental indenture which affects the Trustee’s own rights, duties or immunities under this Indenture or
otherwise.
Any supplemental indenture authorized by the provisions
of this Section may be executed without the consent of the Holders of any of the Securities at the time Outstanding, notwithstanding
any of the provisions of Section 8.02.
Section 8.02 Supplemental
Indentures With Consent of Securityholders. With the consent (evidenced as provided in Article 7) of the Holders of not less
than a majority in aggregate principal amount of the Securities at the time Outstanding of one or more series affected by such supplemental
indenture (voting as separate series), the Issuer, when authorized by a resolution of the Board of Directors, and the Trustee may, from
time to time and at any time, enter into an indenture or indentures supplemental hereto for the purpose of adding any provisions to or
changing in any manner or eliminating any of the provisions of this Indenture or of any supplemental indenture or of modifying in any
manner the rights of the Holders of the Securities of each such consenting series; provided, that no such supplemental indenture
shall, without the consent of the Holder of each Security so affected, (a) extend the final maturity of any Security, or reduce the
principal amount thereof, or reduce the rate or extend the time of payment of interest thereon, or reduce any amount payable on redemption
thereof, or make the principal thereof (including any amount in respect of original issue discount) or interest thereon payable in any
currency other than that provided in the Securities or in accordance with the terms thereof, or reduce the amount of the principal of
an Original Issue Discount Security that would be due and payable upon an acceleration of the maturity thereof pursuant to Section 5.01
or the amount thereof provable in bankruptcy pursuant to Section 5.02, or (b) waive a continuing default in the payment of principal
of any Security or interest thereon , other than any such default in payment that resulted solely from such acceleration, or change a
provision related to the waiver of past defaults or changes or impair the right of any Securityholder to institute suit for the payment
or conversion thereof or, if the Securities provide therefor, any right of repayment at the option of the Securityholder, or (c) modify
any of the provisions of this section except to increase any required percentage or to provide that certain other provisions cannot be
modified or waived without the consent of the Holder of each Security so affected, or (d) reduce the aforesaid percentage of Securities
of any series, the consent of the Holders of which is required for any such supplemental indenture or the consent of Holders of which
is required for any modification, amendment or waiver of compliance with certain provisions of this Indenture or certain defaults hereunder
and their consequences provided for in this Indenture.
A supplemental indenture which changes or eliminates
any covenant, Event of Default or other provision of this Indenture (1) that has been expressly included solely for the benefit of
one or more particular series of Securities, if any, or (2) which modifies the rights of Holders of Securities of one or more series
with respect to any covenant, Event of Default or provision, shall be deemed not to affect the rights under this Indenture of the Holders
of Securities of any other series with respect to which such covenant, Event of Default or other provision has not been included or so
modified.
Upon the request of the Issuer, accompanied by
a Board Resolution authorizing the execution of any such supplemental indenture, and upon the filing with the Trustee of evidence of the
consent of Securityholders as aforesaid and other documents, if any, required by Section 7.01, the Trustee shall join with the Issuer
in the execution of such supplemental indenture unless such supplemental indenture affects the Trustee’s own rights, duties or immunities
under this Indenture or otherwise, in which case the Trustee may in its discretion, but shall not be obligated to, enter into such supplemental
indenture.
It shall not be necessary for the consent of the
Securityholders under this Section to approve the particular form of any proposed supplemental indenture, but it shall be sufficient
if such consent shall approve the substance thereof.
Promptly after the execution by the Issuer and
the Trustee of any supplemental indenture pursuant to the provisions of this Section, the Trustee shall give a notice thereof to the Holders
of then Outstanding Securities of each series affected thereby, by delivering a notice thereof to such Holders, and in each case such
notice shall set forth in general terms the substance of such supplemental indenture. Any failure of the Trustee to deliver such notice,
or any defect therein, shall not, however, in any way impair or affect the validity of any such supplemental indenture.
Section 8.03 Effect
of Supplemental Indenture. Any supplemental indenture executed pursuant to the provisions of this Article 8 shall comply with
the provisions of the Trust Indenture Act as then in effect. Upon the execution of any supplemental indenture pursuant to the provisions
hereof, this Indenture shall be and be deemed to be modified and amended in accordance therewith and the respective rights, limitations
of rights, obligations, duties and immunities under this Indenture of the Trustee, the Issuer and the Holders of Securities of each series
affected thereby shall thereafter be determined, exercised and enforced hereunder subject in all respects to such modifications and amendments,
and all the terms and conditions of any such supplemental indenture shall be and be deemed to be part of the terms and conditions of this
Indenture for any and all purposes.
Section 8.04 Documents
to Be Given to Trustee. The Trustee, subject to the provisions of Sections 6.01 and 6.02, may receive an Officer’s Certificate
and an Opinion of Counsel as conclusive evidence that any supplemental indenture executed pursuant to this Article 8 complies with
the applicable provisions of this Indenture.
Section 8.05 Notation
on Securities in Respect of Supplemental Indentures. Securities of any series authenticated and delivered after the execution of any
supplemental indenture pursuant to the provisions of this Article may bear a notation in form approved by the Trustee for such series
as to any matter provided for by such supplemental indenture or as to any action taken by Securityholders. If the Issuer or the Trustee
shall so determine, new Securities of any series so modified as to conform, in the opinion of the Trustee and the Board of Directors,
to any modification of this Indenture contained in any such supplemental indenture may be prepared by the Issuer, authenticated by the
Trustee and delivered in exchange for the Securities of such series then Outstanding.
ARTICLE 9
CONSOLIDATION,
MERGER, SALE OR CONVEYANCE
Section 9.01 Issuer
May Consolidate, Etc., on Certain Terms. The Issuer shall not consolidate with or merge into any other Person (in a transaction
in which the Issuer is not the surviving corporation) or convey, transfer or lease its properties and assets substantially as an entirety
to any Person, unless (a) the Person formed by such consolidation or into which the Issuer is merged or the Person which acquires
by conveyance or transfer, or which leases, the properties and assets of the Issuer substantially as an entirety (i) shall be a corporation,
limited liability company, partnership or trust, (ii) shall be organized and validly existing under the laws of the United States
of America, any State thereof or the District of Columbia and (iii) shall expressly assume, by an indenture supplemental hereto,
executed and delivered to the Trustee, in form satisfactory to the Trustee, the due and punctual payment of the principal of, interest
on and any Additional Amounts with respect to all the Securities and the performance or observance of every covenant of this Indenture
on the part of the Issuer to be performed, by supplemental indenture satisfactory in form to the Trustee, executed and delivered to the
Trustee, by the Person formed by such consolidation or into which the Issuer shall have been merged or by the Person which shall have
acquired the Issuer’s assets; (b) immediately after giving effect to such transaction, no Event of Default, and no event which,
after notice or lapse of time or both, would become an Event of Default, shall have happened and be continuing; and (c) the Issuer
has delivered to the Trustee an Officer’s Certificate and an Opinion of Counsel, each stating that such consolidation, merger, conveyance,
transfer or lease and, if a supplemental indenture is required in connection with such transaction, such supplemental indenture comply
with this Article and that all conditions precedent herein provided for relating to such transaction have been complied with.
The restrictions in this Section 9.01 shall
not apply to (i) the merger or consolidation of the Issuer with one of its affiliates, if the Board of Directors determines in good
faith that the purpose of such transaction is principally to change the Issuer’s State or jurisdiction of incorporation or convert
the Issuer’s form of organization to another form, or (ii) the merger of the Issuer with or into a single direct or indirect
wholly owned Subsidiary.
Nothing contained in this Article shall apply
to, limit or impose any requirements upon the consolidation or merger of any Person into the Issuer where the Issuer is the survivor of
such transaction, or the acquisition by the Issuer, by purchase or otherwise, of all or any part of the property of any other Person (whether
or not affiliated with the Issuer).
Section 9.02 Successor
Issuer Substituted. Upon any consolidation of the Issuer with, or merger of the Issuer into, any other Person or any conveyance, transfer
or lease of the properties and assets of the Issuer substantially as an entirety in accordance with Section 9.01, the successor Person
formed by such consolidation or into which the Issuer is merged or to which such conveyance, transfer or lease is made shall succeed to,
and be substituted for, and may exercise every right and power of, the Issuer under this Indenture with the same effect as if such successor
Person had been named as the Issuer herein, and thereafter, except in the case of a lease, the predecessor Person shall be relieved of
all obligations and covenants under this Indenture and the Securities.
In case of any such consolidation, merger, sale,
lease or conveyance, such changes in phraseology and form (but not in substance) may be made in the Securities thereafter to be issued
as may be appropriate.
ARTICLE 10
SATISFACTION
AND DISCHARGE OF INDENTURE; DEFEASANCE; UNCLAIMED MONEYS
Section 10.01 Satisfaction
and Discharge of Indenture; Defeasance. (a) If at any time
(i) the
Issuer shall have paid or caused to be paid the principal of and interest on and any Additional Amounts with respect to all the Securities
of any series Outstanding hereunder (other than Securities of such series which have been destroyed, lost or stolen and which have been
replaced or paid as provided in Section 2.09) as and when the same shall have become due and payable, or(ii) the
Issuer shall have delivered to the Trustee for cancellation all Securities of any series theretofore authenticated (other than any Securities
of such series which shall have been destroyed, lost or stolen and which shall have been replaced or paid as provided in Section 2.09),
or
(iii) in
the case of any series of Securities the exact amount (including the currency of payment) of principal of and interest and Additional
Amounts due on which on the dates referred to in clause (B) below can be determined at the time of making the deposit referred to
in such clause,
(A) all the Securities of such series
not theretofore delivered to the Trustee for cancellation shall have become due and payable, or are by their terms to become due and payable
within one year or are to be called for redemption within one year under arrangements satisfactory to the Trustee for the giving of notice
of redemption, and
(B) the Issuer shall have irrevocably
deposited or caused to be deposited with the Trustee as trust funds the entire amount in cash (other than moneys repaid by the Trustee
or any paying agent to the Issuer in accordance with Section 10.04) or, in the case of any series of Securities the payments on which
may only be made in Dollars, U.S. Government Obligations maturing as to principal and interest in such amounts and at such times as will
insure the availability of cash sufficient to pay on any subsequent interest payment date all interest due on such interest payment date
on the Securities of such series and to pay at maturity or upon redemption all Securities of such series (in each case other than any
Securities of such series which shall have been destroyed, lost or stolen and which shall have been replaced or paid as provided in Section 2.09)
not theretofore delivered to the Trustee for cancellation, including principal, interest and Additional Amounts due or to become due to
such date of maturity, as the case may be, and if, in any case described in (i), (ii) or (iii), the Issuer shall also pay or cause
to be paid all other sums payable hereunder by the Issuer, including amounts due the Trustee pursuant to Section 6.06, with respect
to Securities of such series, then this Indenture shall cease to be of further effect with respect to Securities of such series (except
as to (1) rights of registration of transfer, conversion and exchange of Securities of such series and the Issuer’s right of
optional redemption, (2) substitution of mutilated, defaced, destroyed, lost or stolen Securities, (3) rights of Holders of
Securities to receive, solely from the trust fund described in Section 10.01(a)(iii)(B), payments of principal thereof and interest
thereon, upon the original stated due dates therefor (but not upon acceleration) and remaining rights of the Holders to receive, solely
from the trust fund described in Section 10.01(a)(iii)(B), sinking fund payments, if any, (4) the rights (including the Trustee’s
rights under Section 10.05) and immunities of the Trustee hereunder and the Trustee’s obligations under Sections 10.02 and
10.04 and (5) the obligations of the Issuer under Section 3.02), and the Trustee, on demand of the Issuer accompanied by an
Officer’s Certificate and an Opinion of Counsel which complies with Section 11.05 and at the cost and expense of the Issuer,
shall execute proper instruments acknowledging such satisfaction of and discharging this Indenture with respect to such series. The Issuer
agrees to reimburse the Trustee for any costs or expenses thereafter reasonably and properly incurred and to compensate the Trustee for
any services thereafter reasonably and properly rendered by the Trustee in connection with this Indenture or the Securities of such series.
(iv) The
following subsection shall apply to the Securities of each series unless specifically otherwise provided in a Board Resolution, Officer’s
Certificate or indenture supplemental hereto provided pursuant to Section 2.03. In addition to the right to discharge of the Indenture
pursuant to subsection (a) above, the Issuer, at its option and at any time, by written notice by an officer delivered to the Trustee,
may elect to have all of its obligations with respect to all Outstanding Securities of a series discharged (“Legal Defeasance”),
such discharge to be effective on the date that the conditions set forth in clauses (i) through (iv) and (vi) of Section 10.01(d) are
satisfied, and thereafter the Issuer shall be deemed to have paid and discharged the entire Debt on all the Securities of such series,
and satisfied all its other obligations under such Securities and this Indenture insofar as such Securities are concerned and this Indenture
shall cease to be of further effect with respect to Securities of such series (except as to (1) rights of registration of transfer,
conversion and exchange of Securities of such series, (2) substitution of apparently mutilated, defaced, destroyed, lost or stolen
Securities, (3) rights of Holders of Securities to receive, solely from the trust fund described in Section 10.01(d)(i), payments
of principal thereof, interest thereon and any Additional Amounts with respect thereto, upon the original stated due dates therefor (but
not upon acceleration) and remaining rights of the Holders to receive, solely from the trust fund described in Section 10.01(d)(i),
sinking fund payments, if any, (4) the rights (including the Trustee’s rights under Section 10.05) and immunities of the
Trustee hereunder and the Trustee’s obligations with respect to the Securities of such series under Sections 10.02 and 10.04 and
(5) the obligations of the Issuer under Section 3.02).
(ii) The
following subsection shall apply to the Securities of each series unless specifically otherwise provided in a Board Resolution, Officer’s
Certificate or indenture supplemental hereto provided pursuant to Section 2.03. In addition to the right to discharge of the Indenture
pursuant to subsection (a) and to Legal Defeasance pursuant to subsection (b), above, the Issuer, at its option and at any time,
by written notice executed by an officer delivered to the Trustee, may elect to have its obligations under any covenant contained in this
Indenture or in the Board Resolution or supplemental indenture relating to such series pursuant to Section 2.03 discharged with respect
to all Outstanding Securities of a series, this Indenture and any indentures supplemental to this Indenture with respect to such series
(“Covenant Defeasance”), such discharge to be effective on the date the conditions set forth in clauses (i) through
(iii) and (v) through (vi) of Section 10.01(d) are satisfied, and such Securities shall thereafter be deemed
to be not “Outstanding” for the purposes of any direction, waiver, consent or declaration of Securityholders (and any consequences
thereof) in connection with such covenants, but shall continue to be “Outstanding” for all other purposes under this Indenture.
For this purpose, such Covenant Defeasance means that, with respect to the Outstanding Securities of a series, the Issuer may omit to
comply with and shall have no liability in respect of any term, condition or limitation set forth in any such covenant, whether directly
or indirectly, by reason of any reference elsewhere herein to any such covenant or by reason of reference in any such covenant to any
other provision herein or in any other document and such omission to comply shall not constitute an Event of Default under Section 5.01(c) or
otherwise, but except as specified in this Section 10.01(c), the remainder of the Issuer’s obligations under the Securities
of such series, this Indenture, and any indentures supplemental to this Indenture with respect to such series shall be unaffected thereby.
(iii) The
following shall be the conditions to the application of Legal Defeasance (to the extent set forth in subsection (b)) or Covenant Defeasance
(to the extent set forth in subsection (c)) to the Securities of the applicable series:
(i) the
Issuer irrevocably deposits or causes to be deposited in trust with the Trustee or, at the option of the Trustee, with a trustee satisfactory
to the Trustee and the Company under the terms of an irrevocable trust agreement in form and substance satisfactory to the Trustee, cash
or U.S. Government Obligations that will generate cash sufficient to pay principal of and interest on the Outstanding Securities of such
series to maturity or redemption, as the case may be, and to pay all other amounts payable by it hereunder, provided that (A) the
trustee of the irrevocable trust, if any, shall have been irrevocably instructed to pay such funds or the proceeds of such U.S. Government
Obligations to the Trustee and (B) the Trustee shall have been irrevocably instructed to apply such funds or the proceeds of such
U.S. Government Obligations to (x) the principal and interest on all Securities of such series on the date that such principal or
interest is due and payable and (y) any mandatory sinking fund payments on the day on which such payments are due and payable in
accordance with the terms of the Indenture and the Securities of such series, and the Issuer shall also pay or cause to be paid all other
amounts payable hereunder with respect to such series;
(ii) the
Issuer delivers to the Trustee an Officer’s Certificate stating that all conditions precedent specified herein relating to Legal
Defeasance or Covenant Defeasance, as the case may be, have been complied with, and an Opinion of Counsel to the same effect;
(iii) no
Event of Default under subsection (a), (b), (d) or (e) of Section 5.01 shall have occurred and be continuing, and no event
which with notice or lapse of time or both would become such an Event of Default shall have occurred and be continuing, on the date of
such deposit;
(iv) in
the event of an election for Legal Defeasance under subsection (b), the Issuer shall have delivered to the Trustee an Opinion of Counsel
stating that (A) the Issuer has received from, or there has been published by, the Internal Revenue Service a ruling or (B) since
the date of this instrument, there has been a change in the applicable Federal income tax law, in either case (A) or (B) to
the effect that, and based thereon such opinion shall confirm that, the Holders of such Securities will not recognize gain or loss for
Federal income tax purposes as a result of the deposit, defeasance and discharge to be effected with respect to such Securities and will
be subject to Federal income tax on the same amounts, in the same manner and at the same times as would be the case if such deposit, defeasance
and discharge were not to occur;
(v) in
the event of an election for Covenant Defeasance under subsection (c), the Issuer shall have delivered to the Trustee an Opinion of Counsel
to the effect that the Holders of such Securities will not recognize gain or loss for Federal income tax purposes as a result of the deposit
and Covenant Defeasance to be effected with respect to such Securities and will be subject to Federal income tax on the same amount, in
the same manner and at the same times as would be the case if such deposit and Covenant Defeasance were not to occur; and
(vi) notwithstanding
any other provisions of this subsection (d), such defeasance shall be effected in compliance with any additional or substitute terms,
conditions or limitations that may be imposed on the Issuer pursuant to Section 2.03.
After such irrevocable deposit made pursuant to
this Section 10.01(d) and satisfaction of the other applicable conditions set forth in this subsection (d), the Trustee upon
request shall execute proper instruments acknowledging the discharge of the Issuer’s obligations pursuant to this Section 10.01.
Section 10.02 Application
by Trustee of Funds Deposited for Payment of Securities. Subject to Section 10.04, all moneys deposited with the Trustee (or
other trustee) pursuant to Section 10.01 shall be held in trust and applied by it to the payment, either directly or through any
paying agent (including the Issuer acting as its own paying agent), to the Holders of the particular Securities of such series for the
payment or redemption of which such moneys have been deposited with the Trustee, of all sums due and to become due thereon for principal
and interest; but such money need not be segregated from other funds except to the extent required by law.
Section 10.03 Repayment
of Moneys Held by Paying Agent. In connection with the satisfaction and discharge of this Indenture with respect to Securities of
any series, all moneys then held by any paying agent under the provisions of this Indenture with respect to such series of Securities
shall, upon demand of the Issuer, be repaid to it or paid to the Trustee and thereupon such paying agent shall be released from all further
liability with respect to such moneys.
Section 10.04 Return
of Moneys Held by Trustee and Paying Agent Unclaimed for Two Years. Any moneys deposited with or paid to the Trustee or any paying
agent for the payment of the principal of, interest on or Additional Amounts in respect of any Security of any series and not applied
but remaining unclaimed for two years after the date upon which such principal, interest or additional amount shall have become due and
payable, shall be repaid to the Issuer by the Trustee for such series or such paying agent, and the Holder of the Securities of such series
shall thereafter look only to the Issuer for any payment which such Holder may be entitled to collect, and all liability of the Trustee
or any paying agent with respect to such moneys shall thereupon cease.
Section 10.05 Indemnity
for U.S. Government Obligations. The Issuer shall pay and indemnify the Trustee against any tax, fee or other charge imposed on or
assessed against the U.S. Government Obligations deposited pursuant to Section 10.01 or the principal or interest received in respect
of such obligations.
ARTICLE 11
MISCELLANEOUS
PROVISIONS
Section 11.01 No
Recourse. No recourse under or upon any obligation, covenant or agreement of this Indenture, or of any Security, or for any claim
based thereon or otherwise in respect thereof, shall be had against any incorporator, stockholder, officer or director, past, present
or future as such, of the Issuer or of any predecessor or successor corporation, either directly or through the Issuer or any such predecessor
or successor corporation, whether by virtue of any constitution, statute or rule of law, or by the enforcement of any assessment
or penalty or otherwise; it being expressly understood that this Indenture and the obligations issued hereunder are solely corporate obligations,
and that no such personal liability whatever shall attach to, or is or shall be incurred by, the incorporators, stockholders, officers
or directors as such, of the Issuer or of any predecessor or successor corporation, or any of them, because of the creation of the indebtedness
hereby authorized, or under or by reason of the obligations, covenants or agreements contained in this Indenture or in any of the Securities
or implied therefrom; and that any and all such personal liability of every name and nature, either at common law or in equity or by constitution
or statute, of, and any and all such rights and claims against, every such incorporator, stockholder, officer or director as such, because
of the creation of the indebtedness hereby authorized, or under or by reason of the obligations, covenants or agreements contained in
this Indenture or in any of the Securities or implied therefrom, are hereby expressly waived and released as a condition of, and as a
consideration for, the execution of this Indenture and the issuance of such Securities.
Section 11.02 Provisions
of Indenture for the Sole Benefit of Parties and Holders of Securities. Nothing in this Indenture or in the Securities, expressed
or implied, shall give or be construed to give to any person, firm or corporation, other than the parties hereto and their successors
and the Holders of the Securities any legal or equitable right, remedy or claim under this Indenture or under any covenant or provision
herein contained, all such covenants and provisions being for the sole benefit of the parties hereto and their successors and of the Holders
of the Securities.
Section 11.03 Successors
and Assigns of Issuer Bound by Indenture. All the covenants, stipulations, promises and agreements contained in this Indenture by
or on behalf of the Issuer shall bind its successors and assigns, whether so expressed or not.
Section 11.04 Notices
and Demands on Issuer, Trustee and Holders of Securities. Any notice or demand which by any provision of this Indenture is required
or permitted to be given or served by the Trustee or by the Holders of Securities to or on the Issuer may be delivered, given or served
by being deposited postage prepaid, first-class mail (except as otherwise specifically provided herein) addressed (until another address
of the Issuer is filed by the Issuer with the Trustee) to Avenue Therapeutics, Inc., 1111 Kane Concourse, Suite 301, Bay Harbor
Islands, FL 33154, Attn: Corporate Secretary.
Any notice, direction, request or demand by the
Issuer or any Holder of Securities to or upon the Trustee shall be deemed to have been sufficiently given or made, for all purposes, if
given or made at _______, Attn: _______.
Where this Indenture provides for notice to Holders
of Securities, such notice shall be sufficiently given (unless otherwise herein expressly provided) if in writing and mailed, first-class
postage prepaid, to each Holder entitled thereto, at his, her or its last address as it appears in the Security register. In case, by
reason of the suspension of or irregularities in regular mail service, it shall be impracticable to mail notice of any event to Holders
of Securities when said notice is required to be given pursuant to any provision of this Indenture or of the Securities, then any manner
of giving such notice as shall be satisfactory to the Trustee shall be deemed to be a sufficient giving of such notice.
In case, by reason of the suspension of or irregularities
in regular mail service, it shall be impracticable to mail notice to the Holders when such notice is required to be given pursuant to
any provision of this Indenture, then any manner of giving such notice as shall be satisfactory to the Trustee shall be deemed to be a
sufficient giving of such notice.
Where this Indenture provides for notice of any
event to a Holder of a Global Security, such notice shall be sufficiently given if given to the Depositary for such Security (or its designee),
pursuant to the Applicable Procedures of the Depositary, not later than the latest date, if any, and not earlier than the earliest date,
if any, prescribed for the giving of such notice.
Neither the failure to give notice, nor any defect
in any notice so given, to any particular Holder of a Security shall affect the sufficiency of such notice with respect to other Holders
of Securities given as provided above.
Where this Indenture provides for notice in any
manner, such notice may be waived in writing by the Person entitled to receive such notice either before or after the event, and such
waiver shall be the equivalent of such notice. Waivers of notice by Holders shall be filed with the Trustee, but such filing shall not
be a condition precedent to the validity of any action taken in reliance upon such waiver.
Section 11.05 Officer’s
Certificates and Opinions of Counsel; Statements to Be Contained Therein. Upon any application or demand by the Issuer to the Trustee
to take any action under any of the provisions of this Indenture, the Issuer shall furnish to the Trustee an Officer’s Certificate
stating that all conditions precedent provided for in this Indenture relating to the proposed action have been complied with and an Opinion
of Counsel stating that in the opinion of such counsel all such conditions precedent have been complied with, except that in the case
of any such application or demand as to which the furnishing of such documents is specifically required by any provision of this Indenture
relating to such particular application or demand, no additional certificate or opinion need be furnished.
Each certificate or opinion provided for in this
Indenture and delivered to the Trustee with respect to compliance with a condition or covenant provided for in this Indenture shall include
(a) a statement that the person making such certificate or opinion has read such covenant or condition, (b) a brief statement
as to the nature and scope of the examination or investigation upon which the statements or opinions contained in such certificate or
opinion are based, (c) a statement that, in the opinion of such person, he or she has made such examination or investigation as is
necessary to enable him or her to express an informed opinion as to whether or not such covenant or condition has been complied with and
(d) a statement as to whether or not, in the opinion of such person, such condition or covenant has been complied with.
Any certificate, statement or opinion of an officer
of the Issuer may be based, insofar as it relates to legal matters, upon a certificate or opinion of or representations by counsel, unless
such officer knows that the certificate or opinion or representations with respect to the matters upon which his or her certificate, statement
or opinion may be based as aforesaid are erroneous, or in the exercise of reasonable care should know that the same are erroneous. Any
certificate, statement or opinion of counsel may be based, insofar as it relates to factual matters, information with respect to which
is in the possession of the Issuer, upon the certificate, statement or opinion of or representations by an officer or officers of the
Issuer, unless such counsel knows that the certificate, statement or opinion or representations with respect to the matters upon which
his or her certificate, statement or opinion may be based as aforesaid are erroneous, or in the exercise of reasonable care should know
that the same are erroneous.
Any certificate, statement or opinion of an officer
of the Issuer or of counsel may be based, insofar as it relates to accounting matters, upon a certificate or opinion of or representations
by an accountant or firm of accountants in the employ of the Issuer, unless such officer or counsel, as the case may be, knows that the
certificate or opinion or representations with respect to the accounting matters upon which his or her certificate, statement or opinion
may be based as aforesaid are erroneous, or in the exercise of reasonable care should know that the same are erroneous.
Any certificate or opinion of any independent firm
of public accountants filed with and directed to the Trustee shall contain a statement that such firm is independent.
Section 11.06 Payments
Due on Saturdays, Sundays and Holidays. If the date of maturity of interest on or principal of the Securities of any series or the
date fixed for redemption or repayment of any such Security, or the last day on which a Holder has the right to convert any Security,
shall not be a Business Day, then payment of interest or principal, or any conversion, need not be made on such date, but may be made
on the next succeeding Business Day with the same force and effect as if made on the date of maturity or the date fixed for redemption
or on such last day for conversion, and no interest shall accrue for the period after such date.
Section 11.07 Conflict
of Any Provision of Indenture With Trust Indenture Act of 1939. If and to the extent that any provision of this Indenture limits,
qualifies or conflicts with another provision included in this Indenture by operation of Sections 310 to 317, inclusive, of the Trust
Indenture Act of 1939, such incorporated provision shall control.
Section 11.08 New
York Law to Govern. This Indenture and each Security shall be deemed to be a contract under the laws of the State of New York, and
for all purposes shall be governed by and construed in accordance with the laws of such State without regard to any principle of conflict
of laws that would require or permit the application of the laws of any other jurisdiction, except as may otherwise be required by mandatory
provisions of law.
Section 11.09 Counterparts.
This Indenture may be executed in any number of counterparts, each of which shall be an original; but such counterparts shall together
constitute but one and the same instrument.
Section 11.10 Effect
of Headings. The Article and Section headings herein and the Table of Contents are for convenience only and shall not affect
the construction hereof.
Section 11.11 Actions
by Successor. Any act or proceeding by any provision of this Indenture authorized or required to be done or performed by any board
of directors or its equivalent, committee or officer of the Issuer shall and may be done and performed with like force and effect by the
corresponding board, committee or officer of any corporation that shall at the time be the lawful successor of the Issuer.
Section 11.12 Severability.
In case any one or more of the provisions contained in this Indenture or in the Securities of any series shall for any reason be held
to be invalid, illegal or unenforceable in any respect, such invalidity, illegality or unenforceability shall not affect any other provisions
of this Indenture or of such Securities, but this Indenture and such Securities shall be construed as if such invalid or illegal or unenforceable
provision had never been contained herein or therein.
ARTICLE 12
REDEMPTION
OF SECURITIES AND SINKING FUNDS
Section 12.01 Applicability
of Article. The provisions of this Article shall be applicable to the Securities of any series which are redeemable before their
maturity or to any sinking fund for the retirement of Securities of a series, except as otherwise specified, as contemplated by Section 2.03
for Securities of such series.
Section 12.02 Notice
of Redemption; Partial Redemptions. Notice of redemption to the Holders of Securities of any series to be redeemed as a whole or in
part at the option of the Issuer shall be given by providing notice of such redemption at least 10 days and not more than 60 days prior
to the date fixed for redemption to such Holders of Securities of such series at their last addresses as they shall appear upon the Security
register. Any notice which is given in the manner herein provided shall be conclusively presumed to have been duly given, whether or not
the Holder receives the notice. Failure to give notice or any defect in the notice to the Holder of any Security of a series designated
for redemption as a whole or in part shall not affect the validity of the proceedings for the redemption of any other Security of such
series.
The notice of redemption to each such Holder shall
specify the principal amount of each Security of such series held by such Holder to be redeemed, the date fixed for redemption, the redemption
price, the place or places of payment, that payment will be made upon presentation and surrender of such Securities, that such redemption
is pursuant to the mandatory or optional sinking fund, or both, if such be the case, that interest accrued to the date fixed for redemption
will be paid as specified in such notice and that on and after said date interest thereon or on the portions thereof to be redeemed will
cease to accrue and shall also specify, if applicable, the conversion price then in effect and the date on which the right to convert
such Securities or the portions thereof to be redeemed will expire. In case any Security of a series is to be redeemed in part only, the
notice of redemption shall state the portion of the principal amount thereof to be redeemed and shall state that on and after the date
fixed for redemption, upon surrender of such Security, a new Security or Securities of such series in principal amount equal to the unredeemed
portion thereof will be issued.
The notice of redemption of Securities of any series
to be redeemed at the option of the Issuer shall be given by the Issuer or, at the Issuer’s request, by the Trustee in the name
and at the expense of the Issuer.
On or before the redemption date specified in the
notice of redemption given as provided in this Section, the Issuer will deposit with the Trustee or with one or more paying agents (or,
if the Issuer is acting as its own paying agent, set aside, segregate and hold in trust as provided in Section 3.04) an amount of
money sufficient to redeem on the redemption date all the Securities of such series so called for redemption (other than those Securities
theretofore surrendered for conversion into Common Stock or any other securities of the Company in accordance with their terms) at the
appropriate redemption price, together with accrued interest to the date fixed for redemption. If any Security called for redemption is
converted pursuant hereto and in accordance with the terms thereof, any money deposited with the Trustee or any paying agent or so segregated
and held in trust for the redemption of such Security shall be paid to the Issuer upon the Issuer’s request, or, if then held by
the Issuer, shall be discharged from such trust. The Issuer will deliver to the Trustee at least 10 days prior to the date the notice
required to be delivered to the Holders is to be sent (unless a shorter time period shall be acceptable to the Trustee) an Officer’s
Certificate (which need not comply with Section 11.05) stating the aggregate principal amount of Securities to be redeemed. In case
of a redemption at the election of the Issuer prior to the expiration of any restriction on such redemption, the Issuer shall deliver
to the Trustee, prior to the giving of any notice of redemption to Holders pursuant to this Section, an Officer’s Certificate stating
that such restriction has been complied with.
If less than all the Securities of a series are
to be redeemed, the Trustee shall select, in such manner as it shall deem appropriate and fair, Securities of such series to be redeemed
in whole or in part. Securities may be redeemed in part in multiples equal to the minimum authorized denomination for Securities of such
series or any multiple thereof. The Trustee shall promptly notify the Issuer in writing of the Securities of such series selected for
redemption and, in the case of any Securities of such series selected for partial redemption, the principal amount thereof to be redeemed.
For all purposes of this Indenture, unless the context otherwise requires, all provisions relating to the redemption of Securities of
any series shall relate, in the case of any Security redeemed or to be redeemed only in part, to the portion of the principal amount of
such Security which has been or is to be redeemed. If any Security selected for partial redemption is surrendered for conversion after
such selection, the converted portion of such Security shall be deemed (so far as may be possible) to be the portion selected for redemption.
Section 12.03 Payment
of Securities Called for Redemption. If notice of redemption has been given as above provided, the Securities or portions of Securities
specified in such notice shall become due and payable on the date and at the place stated in such notice at the applicable redemption
price, together with interest accrued to the date fixed for redemption, and on and after said date (unless the Issuer shall default in
the payment of such Securities at the redemption price, together with interest accrued to said date) interest on the Securities or portions
of Securities so called for redemption shall cease to accrue, and such Securities shall cease from and after the date fixed for redemption
to be convertible into Common Stock or any other securities of the Company (to the extent otherwise convertible in accordance with their
terms), if applicable, and cease to be entitled to any benefit or security under this Indenture, and except as provided in the paragraph
below, the Holders thereof shall have no right in respect of such Securities except the right to receive the redemption price thereof
and unpaid interest to the date fixed for redemption. On presentation and surrender of such Securities at a place of payment specified
in said notice, said Securities or the specified portions thereof shall be paid and redeemed by the Issuer at the applicable redemption
price, together with interest accrued thereon to the date fixed for redemption; provided, that payment of interest becoming due
on or prior to the date fixed for redemption shall be payable to the Holders of such Securities registered as such on the relevant record
date subject to the terms and provisions of Sections 2.03 and 2.07 hereof.
If any Security called for redemption shall not
be so paid upon surrender thereof for redemption, the principal shall, until paid or duly provided for, bear interest from the date fixed
for redemption at the rate of interest or Yield to Maturity (in the case of an Original Issue Discount Security) borne by such Security
and, if applicable, such Security shall remain convertible into Common Stock or any other securities of the Company until the principal
of such Security shall have been paid or duly provided for.
Upon presentation of any Security redeemed in part
only, the Issuer shall execute and the Trustee shall authenticate and deliver to or on the order of the Holder thereof, at the expense
of the Issuer, a new Security or Securities of such series, of authorized denominations, in principal amount equal to the unredeemed portion
of the Security so presented.
Section 12.04 Exclusion
of Certain Securities from Eligibility for Selection for Redemption. Securities shall be excluded from eligibility for selection for
redemption if they are identified by registration and certificate number in an Officer’s Certificate delivered to the Trustee at
least 40 days prior to the last date on which notice of redemption may be given as being owned of record and beneficially by, and not
pledged or hypothecated by, either (a) the Issuer or (b) an entity specifically identified in such written statement as directly
or indirectly controlling or controlled by or under direct or indirect common control with the Issuer.
Section 12.05 Mandatory
and Optional Sinking Funds. The minimum amount of any sinking fund payment provided for by the terms of the Securities of any series
is herein referred to as a “mandatory sinking fund payment”, and any payment in excess of such minimum amount provided
for by the terms of the Securities of any series is herein referred to as an “optional sinking fund payment”. The date
on which a sinking fund payment is to be made is herein referred to as the “sinking fund payment date”.
In lieu of making all or any part of any mandatory
sinking fund payment with respect to any series of Securities in cash, the Issuer may at its option (a) deliver to the Trustee Securities
of such series theretofore purchased or otherwise acquired (except upon redemption pursuant to the mandatory sinking fund) by the Issuer
or receive credit for Securities of such series (not previously so credited) theretofore purchased or otherwise acquired (except as aforesaid)
by the Issuer and delivered to the Trustee for cancellation pursuant to Section 2.10 and, if applicable, receive credit for Securities
(not previously so credited) converted into Common Stock or any other securities of the Company and so delivered to the Trustee for cancellation,
(b) receive credit for optional sinking fund payments (not previously so credited) made pursuant to this Section, or (c) receive
credit for Securities of such series (not previously so credited) redeemed by the Issuer through any optional redemption provision contained
in the terms of such series. Securities so delivered or credited shall be received or credited by the Trustee at the sinking fund redemption
price specified in such Securities.
On or before the 60th day next preceding each sinking
fund payment date for any series, the Issuer will deliver to the Trustee an Officer’s Certificate (which need not contain the statements
required by Section 11.05) (a) specifying the portion of the mandatory sinking fund payment to be satisfied by payment of cash
and the portion to be satisfied by credit of Securities of such series and the basis for such credit, (b) stating that none of the
Securities of such series for which credit will be taken has theretofore been so credited, (c) stating that no defaults in the payment
of interest or Events of Default with respect to such series have occurred (which have not been waived or cured) and are continuing and
(d) stating whether or not the Issuer intends to exercise its right to make an optional sinking fund payment with respect to such
series and, if so, specifying the amount of such optional sinking fund payment which the Issuer intends to pay on or before the next succeeding
sinking fund payment date. Any Securities of such series to be credited and required to be delivered to the Trustee in order for the Issuer
to be entitled to credit therefor as aforesaid which have not theretofore been delivered to the Trustee shall be delivered for cancellation
pursuant to Section 2.10 to the Trustee with such Officer’s Certificate (or reasonably promptly thereafter if acceptable to
the Trustee). Such Officer’s Certificate shall be irrevocable and upon its receipt by the Trustee the Issuer shall become unconditionally
obligated to make all the cash payments or payments therein referred to, if any, on or before the next succeeding sinking fund payment
date. Failure of the Issuer, on or before any such 60th day, to deliver such Officer’s Certificate and Securities specified in this
paragraph, if any, shall not constitute a default but shall constitute, on and as of such date, the irrevocable election of the Issuer
that the mandatory sinking fund payment for such series due on the next succeeding sinking fund payment date shall be paid entirely in
cash without the option to deliver or credit Securities of such series in respect thereof.
If the sinking fund payment or payments (mandatory
or optional or both) to be made in cash on the next succeeding sinking fund payment date plus any unused balance of any preceding sinking
fund payments made in cash shall exceed $50,000 (or the equivalent thereof in any Foreign Currency or a lesser sum in Dollars or in any
Foreign Currency if the Issuer shall so request) with respect to the Securities of any particular series, such cash shall be applied on
the next succeeding sinking fund payment date to the redemption of Securities of such series at the sinking fund redemption price together
with accrued interest to the date fixed for redemption. If such amount shall be $50,000 (or the equivalent thereof in any Foreign Currency)
or less and the Issuer makes no such request then it shall be carried over until a sum in excess of $50,000 (or the equivalent thereof
in any Foreign Currency) is available, which delay in accordance with this paragraph shall not be a default or breach of the obligation
to make such payment. The Trustee shall select, in the manner provided in Section 12.02, for redemption on such sinking fund payment
date a sufficient principal amount of Securities of such series to which such cash may be applied, as nearly as may be, and shall (if
requested in writing by the Issuer) inform the Issuer of the serial numbers of the Securities of such series (or portions thereof) so
selected. The Trustee, in the name and at the expense of the Issuer (or the Issuer, if it shall so request the Trustee in writing), shall
cause notice of redemption of the Securities of such series to be given in substantially the manner provided in Section 12.02 (and
with the effect provided in Section 12.03) for the redemption of Securities of such series in part at the option of the Issuer. The
amount of any sinking fund payments not so applied or allocated to the redemption of Securities of such series shall be added to the next
cash sinking fund payment for such series and, together with such payment, shall be applied in accordance with the provisions of this
Section. Any and all sinking fund moneys held on the stated maturity date of the Securities of any particular series (or earlier, if such
maturity is accelerated), which are not held for the payment or redemption of particular Securities of such series, shall be applied,
together with other moneys, if necessary, sufficient for the purpose, to the payment of the principal of, and interest on, the Securities
of such series at maturity. The Issuer’s obligation to make a mandatory or optional sinking fund payment shall automatically be
reduced by an amount equal to the sinking fund redemption price allocable to any Securities or portions thereof called for redemption
pursuant to the preceding paragraph on any sinking fund payment date and converted into Common Stock in accordance with the terms of such
Securities; provided that, if the Trustee is not the conversion agent for the Securities, the Issuer or such conversion agent shall
give the Trustee written notice on or prior to the date fixed for redemption of the principal amount of Securities or portions thereof
so converted.
On or before each sinking fund payment date, the
Issuer shall pay to the Trustee in cash or shall otherwise provide for the payment of all interest accrued to the date fixed for redemption
on Securities to be redeemed on such sinking fund payment date.
The Trustee shall not redeem or cause to be redeemed
any Securities of a series with sinking fund moneys or give any notice of redemption of Securities for such series by operation of the
sinking fund during the continuance of a default in payment of interest on such Securities or of any Event of Default except that, where
delivery of notice of redemption of any Securities shall theretofore have been made, the Trustee shall redeem or cause to be redeemed
such Securities, provided that it shall have received from the Issuer a sum sufficient for such redemption. Except as aforesaid, any moneys
in the sinking fund for such series at the time when any such default or Event of Default shall occur, and any moneys thereafter paid
into the sinking fund, shall, during the continuance of such default or Event of Default, be deemed to have been collected under Article 5
and held for the payment of all such Securities. In case such Event of Default shall have been waived as provided in Section 5.10,
or the default cured on or before the 60th day preceding the sinking fund payment date in any year, such moneys shall thereafter be applied
on such sinking fund payment date in accordance with this Section to the redemption of such Securities.
[Signature pages follow]
IN WITNESS WHEREOF, the parties hereto have caused
this Indenture to be duly executed as of _________________, 20____.
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AVENUE THERAPEUTICS, INC. |
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Name: |
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Title: |
[Signature Page to Indenture]
Exhibit 5.1
Troutman Pepper Hamilton Sanders LLP
301 S College Street, Suite 3400
Charlotte, NC 28202
troutman.com
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December 4, 2024
Avenue Therapeutics, Inc.
1111 Kane Concourse, Suite 301
Bay Harbor Islands, Florida 33154
Re: Registration Statement on Form S-3
Ladies and Gentlemen:
We have acted as counsel to Avenue Therapeutics, Inc.,
a Delaware corporation (the “Company”), in connection with the Company’s registration statement on Form S-3
(the “Registration Statement”), including the prospectus that is part of the Registration Statement (the “Base
Prospectus”) filed on the date hereof with the Securities and Exchange Commission under the Securities Act of 1933, as amended
(the “Securities Act”). The Base Prospectus provides that it will be supplemented in the future by one or more prospectus
supplements (each, a “Prospectus Supplement”). The Base Prospectus, as supplemented by the various Prospectus Supplements,
will provide for the issuance and sale from time to time by the Company of up to an aggregate of $35,000,000 (subject to the limitations
of General Instruction I.B.6 of Form S-3, if then applicable) of any or all of (i) shares of common stock, $0.0001 par value
per share (the “Common Stock”), of the Company, (ii) shares of preferred stock, par value $0.0001 per share (the
“Preferred Stock”), of the Company, (iii) one or more series of debt securities of the Company, which may include
convertible debt securities of the Company that constitute a part of or that are issuable upon the conversion or exercise of other Securities
in the Registration Statement (the “Debt Securities”), (iv) warrants to purchase shares of Common Stock, Preferred
Stock or Debt Securities, or all three (the “Warrants”), (v) units comprised of one or more shares of Common Stock,
shares of Preferred Stock, Debt Securities and/or Warrants, in any combination (the “Units”), or (vi) any combination
of the foregoing securities. The Common Stock, Preferred Stock, Debt Securities, Warrants and Units are collectively herein referred to
as the “Registered Securities.” The Registered Securities may be offered and sold by the Company from time to time
pursuant to Rule 415(a)(5) under the Securities Act as set forth in the Base Prospectus, as supplemented by the various Prospectus
Supplements that may be filed under the Securities Act. This opinion letter is furnished to you at your request to enable you to fulfill
the requirements of Item 601(b)(5) of Regulation S-K, in connection with the filing of the Registration Statement.
The Debt Securities will be issued pursuant to
one or more indentures in substantially the form filed as an exhibit to the Registration Statement, as amended or supplemented from time
to time (each, an “Indenture”), between the Company, as obligor, and a trustee chosen by the Company and qualified
to act as such under the Trust Indenture Act of 1939, as amended (the “Trustee”).
We have reviewed the corporate proceedings taken
by the Company with respect (1) the filing of the Registration Statement by the Company and (2) the offer, sale and issuance
of the Registered Securities by the Company, subject to in the case of each offer, sale and issuance of Registered Securities, a specific
further authorization for the offer, sale, issuance, execution, delivery and performance by proper action (the “Authorizing Resolutions”)
of the Company’s board of directors (the “Board”). We have also examined and relied upon originals or copies
of such corporate records, documents, agreements or other instruments of the Company, and such certificates and records of public officials,
and such other papers, as we have deemed necessary or appropriate in connection herewith. As to all matters of fact (including, without
limitation, factual conclusions and characterizations and descriptions of purpose, intention or other state of mind) we have relied entirely
upon certificates of officers of the Company, and have assumed, without independent inquiry, the accuracy of those certificates.
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In rendering this opinion, we have assumed the
genuineness and authenticity of all signatures on original documents; the legal capacity of all natural persons; the authenticity of all
documents submitted to us as originals; the conformity to originals of all documents submitted to us as certified or photocopies; the
accuracy and completeness of all documents and records reviewed by us; the accuracy, completeness and authenticity of certificates issued
by any governmental official, office or agency and the absence of change in the information contained therein from the effective date
of any such certificate; and the due authorization, execution and delivery of all documents where authorization, execution and delivery
are prerequisites to the effectiveness of such documents.
For purposes of this opinion letter, we have assumed that:
(i) the
issuance, sale, amount, and terms of each of the Registered Securities to be offered from time to time by the Company will be duly authorized
and established by proper action of the Board, and in accordance with the Third Amended and Restated Certificate of Incorporation of the
Company, as amended from time to time (the “Certificate of Incorporation”), the Second Amended and Restated By-Laws
of the Company, as amended from time to time (the “Bylaws”), and applicable Delaware law, and that, at the time of
each such issuance and sale of such Registered Securities, the Company will continue to be validly existing and in good standing under
the laws of the State of Delaware, with the requisite corporate power and authority to issue and sell all such Registered Securities at
such time;
(ii) any
shares of Common Stock (including any such shares issuable upon exercise of Warrants) issued by the Company pursuant to the Registration
Statement, the Base Prospectus, and the related Prospectus Supplement, from time to time will not exceed the maximum authorized number
of shares of Common Stock under the Certificate of Incorporation, as the same may have been amended, minus that number of shares of Common
Stock that may have been issued and are outstanding, or are reserved for issuance for other purposes, at such time;
(iii) any
shares of Preferred Stock (including any such shares issuable upon exercise of Warrants) issued by the Company pursuant to the Registration
Statement, the Base Prospectus and the related Prospectus Supplement, from time to time will not exceed the maximum authorized number
of shares of Preferred Stock under the Certificate of Incorporation, as the same may have been amended, minus that number of shares of
Common Stock that may have been issued and are outstanding, or are reserved for issuance for other purposes, at such time;
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(iv) any
Warrants issued by the Company pursuant to the Registration Statement, the Base Prospectus and the related Prospectus Supplement, from
time to time, will be issued under one or more valid, binding, and enforceable warrant agreements (each a “Warrant Agreement”);
the Board will have taken all necessary corporate action to authorize the creation of and the terms of such Warrants and the issuance
of the Common Stock and/or Preferred Stock to be issued upon exercise of such Warrants and to approve the Warrant Agreement; neither such
Warrants nor such Warrant Agreement will include any provision that is unenforceable, that violates any applicable law or results in a
default under or breach of any agreement or instrument binding upon the Company; such Warrants or certificates representing such Warrants
will have been duly executed, countersigned, registered and delivered in accordance with the provisions of such Warrant Agreement; the
issuance and sale of the Warrants will not violate any applicable law or result in a default under or breach of any agreement or instrument
binding upon the Company and will comply with any requirements or restrictions imposed by any court or governmental body having jurisdiction
over the Company;
(v) any
Debt Securities issued by the Company pursuant to the Registration Statement, the Base Prospectus and the related Prospectus Supplement,
from time to time, will be issued under and in conformity with, a valid, binding and enforceable Indenture, which shall be delivered by
the Trustee, and the Trustee will have all requisite power and authority to effect the transactions contemplated by such Indenture, and
the Trustee or an authenticating agent for the Trustee will duly authenticate the Debt Securities pursuant to the applicable Indenture,
and the applicable Indenture will be the valid and binding obligation of the Trustee and will be enforceable against the Trustee in accordance
with its terms. We are expressing no opinion herein as to the application of or compliance with any foreign, federal or state law or regulation
to the power, authority or competence of any party, other than the Company, to the applicable Indenture;
(vi) any
Units issued by the Company pursuant to the Registration Statement, the Base Prospectus and the related Prospectus Supplement may be issued
pursuant to a valid, binding and enforceable Unit Agreement (the “Unit Agreement”) between the Company and a bank or
trust company as unit agent;
(vii) New
York law may apply to the applicable Indenture, the Warrants, any underwriting agreement or other agreement but New York law does not
apply generally;
(viii) all
requisite third-party consents necessary to register and/or issue the Registered Securities have been obtained by the Company;
(ix) certificates
representing shares of Common Stock, if any, will have been duly executed, countersigned, registered and delivered, or if uncertificated,
valid book-entry notations will have been made in the share register of the Company, in each case in accordance with the provisions of
the Company’s Certificate of Incorporation and Bylaws, each as amended and then in effect; and
(x) all
Registered Securities will be offered and sold in compliance with applicable federal and state securities or “blue sky” laws
and in the manner specified in the Registration Statement and the applicable Prospectus Supplement.
Subject to the limitations set forth below, we
have made such examination of law as we have deemed necessary for the purposes of expressing the opinions set forth in this letter. Such
opinions are limited solely to matters governed by the General Corporation Law of the State of Delaware and the internal laws of the State
of New York, in each case without regard to conflict or choice of law principles and as applied by courts located in the particular jurisdiction,
the applicable provisions of the Delaware Constitution, the reported judicial decisions interpreting such laws of the State of Delaware.
Based upon the foregoing, we are of the opinion that:
1. The
Common Stock, when (a) Authorizing Resolutions with respect to Common Stock have been adopted, (b) the terms for the offer and
sale of the Common Stock have been established in conformity with such Authorizing Resolutions, (c) such Common Stock has been issued
and sold as contemplated by the Registration Statement, the Base Prospectus, and the applicable Prospectus Supplement and (d) the
Company has received the consideration provided for in the applicable Prospectus Supplement and any applicable definitive purchase, underwriting
or similar agreement, which must have a value not less than the par value thereof, or upon conversion, exchange or exercise of Preferred
Stock or Warrants in accordance with the terms of such Registered Security or the instrument governing such Registered Security providing
for such conversion, exchange or otherwise, will be validly issued, fully paid and nonassessable.
2. The
Preferred Stock, when (a) Authorizing Resolutions with respect to Preferred Stock have been adopted, (b) the terms for the offer
and sale of the Preferred Stock have been established in conformity with such Authorizing Resolutions, (c) such Preferred Stock has
been issued and sold as contemplated by the Registration Statement, the Base Prospectus and the applicable Prospectus Supplement and (d) the
Company has received the consideration provided for in the applicable Prospectus Supplement and any applicable definitive purchase, underwriting
or similar agreement, which must have a value not less than the par value thereof, or upon conversion, exchange or exercise of Warrants,
in accordance with the terms of such Registered Security or the instrument governing such Registered Security providing for such conversion,
exchange or otherwise, will be validly issued, fully paid and nonassessable.
3. The
Warrants, when (a) Authorizing Resolutions with respect to the Warrants have been adopted, (b) the terms of such Warrants and
for their issuance and sale have been established in conformity with such Authorizing Resolutions, (c) such Warrants have been issued
and sold as contemplated by the Registration Statement, the Base Prospectus and the applicable Prospectus Supplement, (d) the Company
has received the consideration provided for in the applicable supplement to the Base Prospectus and any applicable definitive purchase,
underwriting or similar agreement and (e) such Warrants have been authenticated or countersigned in accordance with the provisions
of the Warrant Agreement, will be valid and binding obligations of the Company enforceable against the Company in accordance with their
respective terms.
4. The
Debt Securities, when (a) Authorizing Resolutions with respect to such Debt Securities have been adopted, (b) the terms of such
Debt Securities and for their issuance and sale have been established in conformity with such Authorizing Resolutions and the Indenture,
(d) such Debt Securities have been issued and sold as contemplated by the Registration Statement, the Base Prospectus and the applicable
Prospectus Supplement, (e) the Company has received the consideration provided for in the applicable Prospectus Supplement and any
applicable definitive purchase, underwriting or similar agreement and (f) such Debt Securities have been executed and delivered against
the payment specified therefor and pursuant to an Indenture duly authorized, executed and delivered by the Company and the Trustee, will
be valid and binding obligations of the Company enforceable against the Company in accordance with their respective terms.
| |
5. The
Units, when (a) Authorizing Resolutions with respect to the Units have been adopted, (b) the terms of such Units and for their
issuance and sale have been established in conformity with such Authorizing Resolutions, (c) such Units have been issued and sold
as contemplated by the Registration Statement, the Base Prospectus and the applicable Prospectus Supplement, (d) the Company has
received the consideration provided for in the applicable Prospectus Supplement and any applicable definitive purchase, underwriting or
similar agreement and (e) such Units have been authenticated or countersigned in accordance with the Unit Agreement, if applicable,
will be valid and binding obligations of the Company enforceable against the Company in accordance with their respective terms.
In addition, our opinions in paragraphs 3, 4,
and 5 above are subject to: (a) the effect of bankruptcy, insolvency, reorganization, fraudulent conveyance, moratorium or other
similar laws now or hereafter in effect relating to or affecting the rights and remedies of creditors; (b) the effect of general
principles of equity, including without limitation, concepts of materiality, reasonableness, good faith and fair dealing and the possible
unavailability of specific performance or injunctive relief, regardless of whether enforcement is considered in a proceeding in equity
or at law, and the discretion of the court before which any proceeding therefore may be brought; (c) the unenforceability under certain
circumstances under law or court decisions of provisions providing for the indemnification of, or contribution to, a party with respect
to a liability where such indemnification or contribution is contrary to public policy; (d) the rights or remedies available to any
party for violations or breaches of any provisions of the Warrants, Debt Securities or Units, as applicable that are immaterial or the
enforcement of which would be unreasonable under the then existing circumstances; (e) the rights or remedies available to any party
for material violations or breaches that are the proximate result of actions taken by any party to the Warrants, Debt Securities, or Units,
as applicable, other than the party against whom enforcement is sought, which actions such other party is not entitled to take pursuant
to the Warrants, Debt Securities or Units, as applicable, or that otherwise violate applicable laws; (f) the rights or remedies available
to any party that takes discretionary action that is arbitrary, unreasonable or capricious, or is not taken in good faith or in a commercially
reasonable manner, whether or not the Warrants, Debt Securities or Units, as applicable permit such action; or (g) the effect of
the exercise of judicial discretion, whether in a proceeding in equity or at law.
This opinion letter is given as of the date hereof,
and we express no opinion as to the effect of subsequent events or changes in law occurring or becoming effective after the date hereof.
We assume no obligation to update this opinion letter or otherwise advise you with respect to any facts or circumstances or changes in
law that may hereafter occur or come to our attention.
We hereby consent to the filing of this opinion
as an exhibit to the Registration Statement and to the reference to this firm under the heading “Legal Matters” in the Base
Prospectus included in the Registration Statement. In rendering this opinion and giving this consent, we do not admit that we are an “expert”
within the meaning of the Securities Act.
Very
truly yours, |
|
|
|
/s/
Troutman Pepper Hamilton Sanders LLP |
|
|
|
Troutman
Pepper Hamilton Sanders LLP |
|
Exhibit 23.1
Consent of Independent Registered Public Accounting
Firm
We consent to the use of our report dated March 18,
2024, with respect to the consolidated financial statements of Avenue Therapeutics, Inc., incorporated herein by reference, and to
the reference to our firm under the heading “Experts” in the prospectus.
/s/ KPMG LLP |
|
|
|
New York, NY |
|
December 4, 2024 |
|
Exhibit 107
Calculation of Filing Fee Tables
Form S-3
(Form Type)
Avenue Therapeutics, Inc.
(Exact Name of Registrant as Specified in its Charter)
Table 1: Newly Registered and Carry Forward Securities
|
Security Type |
Security Class Title |
Fee Calculation or Carry Forward Rule |
Amount Registered (1) |
Proposed Maximum Offering Price Per Unit (2) |
Maximum Aggregate Offering Price |
Fee Rate |
Amount of
Registration
Fee |
Carry
Forward
Form
Type |
Carry
Forward
File
Number
|
Carry
Forward
Initial
Effective
Date |
Filing Fee
Previously
Paid In
Connection
with
Unsold Securities
to be
Carried
Forward |
Newly Registered Securities |
Fees to Be Paid |
Equity |
Common stock, par value $0.0001 per share (4)(5) |
457(o) |
|
|
|
|
|
|
|
|
|
|
Equity |
Preferred stock, par value $0.0001 per share (4) |
457(o) |
|
|
|
|
|
|
|
|
|
|
Debt |
Debt Securities |
457(o) |
|
|
|
|
|
|
|
|
|
|
Other |
Warrants (6) |
457(o) |
|
|
|
|
|
|
|
|
|
|
Unallocated (Universal) Shelf |
Unallocated (Universal) Shelf |
415(a)(6) |
|
|
$11,663,013.45(1)(2) |
0.00015310 |
$1,785.61 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Carry Forward Securities |
Carry Forward Securities |
Equity |
Common stock, par value $0.0001 per share (4)(5) |
457(o) |
|
|
|
|
|
Form S-3 |
333-261520 |
December 10, 2021 |
|
|
Equity |
Preferred stock, par value $0.0001 per share (4) |
457(o) |
|
|
|
|
|
Form S-3 |
333-261520 |
December 10, 2021 |
|
|
Debt |
Debt Securities |
457(o) |
|
|
|
|
|
Form S-3 |
333-261520 |
December 10, 2021 |
|
|
Other |
Warrants (6) |
457(o) |
|
|
|
|
|
Form S-3 |
333-261520 |
December 10, 2021 |
|
|
Unallocated (Universal) Shelf |
Unallocated (Universal) Shelf |
415(a)(6) |
|
|
$23,336,986.55(1)(2) |
0.0000927(3)(7) |
|
Form S-3 |
333-261520 |
December 10, 2021 |
$2,163.34(3)(7) |
|
Total Offering Amounts |
|
$35,000,000 |
|
|
|
|
|
|
|
Total Fees Previously Paid |
|
|
|
$2,163.34 |
|
|
|
|
|
Total Fee Offsets |
|
|
|
- |
|
|
|
|
|
Net Fee Due |
|
|
|
$1,785.63 |
|
|
|
|
| (1) | There are being registered hereunder, an indeterminate
number or amount, as the case may be, of common stock, preferred stock, debt securities, and warrants to purchase common stock, as may
be offered by the registrant from time to time, which together shall have an aggregate initial offering price not to exceed $35,000,000.
If any debt securities are issued at an original issue discount, then the principal amount of such debt securities shall
be in such greater amount as shall result in an aggregate initial offering price not to exceed $35,000,000, less the aggregate dollar
amount of all securities previously issued hereunder. The securities included hereunder may be sold separately or with other securities
registered hereunder. The securities included hereunder also include an indeterminate number of securities as may be issued upon conversion
of or exchange for preferred stock or debt securities that provide for conversion or exchange, upon exercise of warrants, or pursuant
to the anti-dilution provisions of any of such securities. In addition, pursuant to Rule 416 of the Securities Act of 1933, as amended,
or the Securities Act, this registration statement also covers any additional securities that may be offered or issued in connection with
any stock splits, stock dividends or similar transactions. Includes rights to acquire common stock or preferred stock of the registrant
under any shareholder rights plan then in effect, if applicable under the terms of any such plan. |
| (2) | The proposed maximum offering price per security will be determined from time to time by the registrant
in connection with the issuance of the securities registered by this registration statement. The proposed maximum aggregate offering price
has been estimated solely for the purpose of calculating the registration fee. In no event will the aggregate maximum offering price of
all securities issued under this registration statement exceed $35,000,000 and the amount of securities sold pursuant to this registration
statement will not exceed the limit in Instruction I.B.6.(a) of Form S-3, as applicable. The amount registered is not specified
as to each class of securities to be registered hereunder pursuant to Instruction 2.A.iii.b. of Item 16(b) of Form S-3 under
the Securities Act. |
| (3) | Calculated in accordance with Rule 457(o) under the Securities Act based on the maximum aggregate
offering price. |
| (4) | Shares of preferred stock or common stock may be issuable upon conversion of debt securities registered
hereunder. No separate consideration will be received for such preferred stock or common stock. |
| (5) | Shares of common stock may be issuable upon conversion of shares of preferred stock registered hereunder.
No separate consideration will be received for such shares of common stock. |
| (6) | Warrants will represent rights to purchase debt securities, common stock or preferred stock registered hereby. Because the warrants
will provide a right only to purchase such securities offered hereunder, no additional registration fee is required. |
| (7) | Pursuant to Rule 415(a)(6) under the Securities Act, the registrant is carrying forward to this
registration statement $23,336,986.55 of unsold securities (the “Unsold Securities”) that have previously been registered
under the registrant’s registration statement on Form S-3 (File No. 333-261520) filed on December 7, 2021, and declared
effective on December 10, 2021 (the “Prior Registration Statement”), and the registration fee of $2,163.34 associated
with the offering of the Unsold Securities (based on the filing fee rate in effect at the time of the filing of the Prior Registration
Statement) will continue to be applied to the Unsold Securities that are being carried forward to this registration statement. No additional
filing fee is due with respect to the Unsold Securities carried forward in this registration statement. To the extent that, after the
filing date hereof and prior to the effectiveness of this registration statement, the registrant sells any Unsold Securities pursuant
to the Prior Registration Statement, the registrant will identify in a pre-effective amendment to this registration statement
the updated amount of Unsold Securities from the Prior Registration Statement to be included in this registration statement pursuant to
Rule 415(a)(6) and the updated amount of new securities to be registered on this registration statement, if any. Pursuant to
Rule 415(a)(6), the offering of securities under the Prior Registration Statement will be deemed terminated as of the date of effectiveness
of this registration statement. |
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