By Dan Strumpf 

U.S. stocks fell Wednesday after a disappointing reading on U.S. economic growth, while investors looked ahead to the Federal Reserve's statement on monetary policy.

The Dow Jones Industrial Average declined 45 points, or 0.3%, to 18065 mid-morning, while the S&P 500 dropped seven points, or 0.3%, to 2108. The Nasdaq Composite Index lost 20 points, or 0.4%, to 5036.

Weighing down shares was a disappointing reading on U.S. gross domestic product, which grew at a 0.2% pace in the first quarter, according to the Commerce Department. The reading came in well below expectations and was the latest report to suggest a downshift in the U.S. economy.

Economists surveyed by The Wall Street Journal expected GDP to grow by 1%. Growth clocked in at 2.2% in the fourth quarter.

"The economic data needs to improve," said David Seaburg, head of sales trading at Cowen and Co. in New York. "It's just not where it needs to be ... it's scary."

The early declines followed modest gains in stocks on Tuesday, with the Dow rising 0.4% and the S&P 500 advancing 0.3%.

Stocks in Europe tumbled as the euro rose sharply against the dollar. Germany's DAX lost 3%, while France's CAC 40 lost 2.4% and the Stoxx Europe 600 index shed 2%. The euro gained 1.5% to $1.1138.

U.S. stocks have advanced in recent weeks, though at an uneven pace. A weak first-quarter earnings season, coupled with slowing economic growth and uncertainty over the Fed's timeline for interest-rate increases, have made for a rockier few months for shares. The S&P 500 is up 2.1% in April, while the Dow has gained 1.6%.

Further clues on the pace of Fed tightening could come this afternoon when the central bank's policy-making committee wraps up its two-day meeting. The Fed is due to release its statement on monetary policy at 2 p.m. ET.

The central bank has made clear it won't start moving rates at its meeting this week. In its statement, the Fed will probably reiterate that it won't start raising rates until it sees more improvement in the labor market and is reasonably confident inflation will move toward its 2% target. Fed Chairwoman Janet Yellen won't hold a news conference following the statement.

Earnings reports were a mixed bag early Wednesday. Analysts expect first-quarter earnings among S&P 500 companies to decline 1.7%, including the 277 companies that have so far reported results, according to FactSet. That would mark the biggest decline in earnings since the third quarter of 2009, though it's an improvement from the expected earnings drop of 4.7% forecast in late March.

U.S. economic data has been weak of late, contributing to weaker quarterly results and a rockier stock market this year, said Kevin Kelly, chief investment officer at Recon Capital Partners, which manages about $200 million.

"The economic numbers certainly have been damaged, and that story that we're doing so well is not as intact," Mr. Kelly said. "You can see that in the market action this year, and you can see that in the earnings."

Mr. Kelly said he remained invested in shares of large, dominant technology companies. He said he boosted his stake in Google Inc. earlier this year.

Shares of Wynn Resorts Ltd. fell 13% after the casino operator said late Tuesday that it swung to a quarterly loss.

Shares of Akamai Technologies Inc. fell 2.6% after the cloud-computing service firm reported first-quarter results that fell short of its own forecast.

Northrop Grumman Corp. shares rose 0.5% after the defense contractor said first-quarter profit fell 19% but results topped expectations.

Starwood Hotels & Resorts Worldwide shares gained 7.8% after the company announced it hired investment bank Lazard to explore strategic alternatives, a move that could put the company up for sale. The hotel operator also reported lower first-quarter earnings.

Shares of Twitter fell 3.4%, extending Tuesday's decline of more than 20% following the early release of disappointing first-quarter results.

Biotechnology stocks rebounded. The Nasdaq Biotechnology Index gained 0.3%, snapping a three-session slide.

In commodities markets, crude-oil futures rose 0.7% to $57.43 a barrel. Gold futures fell 0.2% to $1211.80 an ounce.

The yield on the 10-year Treasury note rose to 2.042% as prices fell.

Write to Dan Strumpf at daniel.strumpf@wsj.com

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