PRAN Prana Biotechnology Ltd ADS

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

February 26, 2014

31 December 2013 Half-Year Financial Results Announcement

MELBOURNE, Wednesday 26 February, 2014: Prana Biotechnology (ASX: PBT/NASDAQ:PRAN) today released its Appendix 4D and Half-Year Financial Results Report for the period ended 31 December 2013.

Financial Summary

Operational Highlights

Commenting on the half year results, Chairman and Chief Executive Officer Mr Geoffrey Kempler said: “It has been a period of significant achievement with the completion of our two phase 2 clinical trials for PBT2. In the last few weeks we’ve reported on the trial results for Huntington disease and will soon report on the Alzheimer’s disease trial.”

The net loss of A$7.93M reflects the significant investment in the development costs of PBT2 as a potential treatment for both Alzheimer’s and Huntington diseases.

The cash balance at 31 December 2013 was A$19.3M, compared with A$13.3M at 30 June 2013. This balance excludes A$4.09M received in January under the R&D Tax Incentive Program.

About Prana Biotechnology Limited

Prana Biotechnology was established to commercialise research into Alzheimer's disease and other major age-related neurodegenerative disorders. The Company was incorporated in 1997 and listed on the Australian Stock Exchange in March 2000 and listed on NASDAQ in September 2002. Researchers at prominent international institutions including The University of Melbourne, The Mental Health Research Institute (Melbourne) and Massachusetts General Hospital, a teaching hospital of Harvard Medical School, contributed to the discovery of Prana’s technology.

For further information please visit the Company’s web site at www.pranabio.com

Forward Looking Statements

This press release contains "forward-looking statements" within the meaning of section 27A of the Securities Act of 1933 and section 21E of the Securities Exchange Act of 1934. The Company has tried to identify such forward-looking statements by use of such words as "expects," "intends," "hopes," "anticipates," "believes," "could," "may," "evidences" and "estimates," and other similar expressions, but these words are not the exclusive means of identifying such statements. Such statements include, but are not limited to any statements relating to the Company's drug development program, including, but not limited to the initiation, progress and outcomes of clinical trials of the Company's drug development program, including, but not limited to, PBT2, and any other statements that are not historical facts. Such statements involve risks and uncertainties, including, but not limited to, those risks and uncertainties relating to the difficulties or delays in financing, development, testing, regulatory approval, production and marketing of the Company’s drug components, including, but not limited to, PBT2, the ability of the Company to procure additional future sources of financing, unexpected adverse side effects or inadequate therapeutic efficacy of the Company's drug compounds, including, but not limited to, PBT2, that could slow or prevent products coming to market, the uncertainty of patent protection for the Company's intellectual property or trade secrets, including, but not limited to, the intellectual property relating to PBT2, and other risks detailed from time to time in the filings the Company makes with Securities and Exchange Commission including its annual reports on Form 20-F and its reports on Form 6-K. Such statements are based on management’s current expectations, but actual results may differ materially due to various factions including those risks and uncertainties mentioned or referred to in this press release. Accordingly, you should not rely on those forward-looking statements as a prediction of actual future results.