FORM 5
[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
[ ] Form 3 Holdings Reported
[ ] Form 4 Transactions Reported		 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

ANNUAL STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

BOYNTON ALTON L		2. Issuer Name and Ticker or Trading Symbol

NORTHWEST BIOTHERAPEUTICS INC [NWBO]		 5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director                    _____ 10% Owner
__X__ Officer (give title below)    _____ Other (specify below)
CHIEF SCIENTIFIC OFFICER
(Last)          (First)          (Middle)

4800 MONGTGOMERY #800		3. Statement for Issuer's Fiscal Year Ended (MM/DD/YYYY)
12/31/2022 
(Street)

BETHSDA, MD 20814
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed(MM/DD/YYYY)
 
6. Individual or Joint/Group Filing(Check Applicable Line)

_X_ Form Filed by One Reporting Person
___ Form Filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		2. Trans. Date2A. Deemed Execution Date, if any3. Trans. Code
(Instr. 8)		4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Amount(A) or (D)Price

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)		2. Conversion or Exercise Price of Derivative Security3. Trans. Date3A. Deemed Execution Date, if any4. Trans. Code
(Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date
(MM/DD/YYYY)		7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)		8. Price of Derivative Security
(Instr. 5)		9. Number of Derivative Securities Beneficially Owned at End of Issuer's Fiscal Year
(Instr. 4)		10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		11. Nature of Indirect Beneficial Ownership
(Instr. 4)
(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
COMMON STOCK OPTIONS $0.23 5/26/2022  G (1)  4900000  5/28/2018 5/28/2028 COMMON STOCK PAR VALUE $0.001 4900000 $0 9761256 D  
COMMON STOCK OPTIONS $0.35 7/27/2022  G (1)  3000000  7/2/2020 12/1/2030 COMMON STOCK PAR VALUE $0.001 3000000 $0 9761256 D  
COMMON STOCK OPTIONS $0.35 12/6/2022  G (1)  4500000  7/2/2020 12/1/2030 COMMON STOCK PAR VALUE $0.001 4500000 $0 9761256 D  
COMMON STOCK OPTIONS $0.35 12/6/2022  G (1)  4500000  7/2/2020 12/1/2030 COMMON STOCK PAR VALUE $0.001 4500000 $0 9761256 D  
Explanation of Responses:
(1) GIFTS FROM DR. BOYNTON FOR ESTATE PLANNING PURPOSES.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
BOYNTON ALTON L
4800 MONGTGOMERY #800
BETHSDA, MD 20814

CHIEF SCIENTIFIC OFFICER
Signatures
/s/ Dr. Alton L. Boynton2/7/2023
**Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
Northwest Biotherapeutics (QB) (USOTC:NWBO)
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