TIDMRENE
RNS Number : 3534I
ReNeuron Group plc
02 December 2022
This announcement contains inside information for the purposes
of Article 7 of Regulation (EU) No 596/2014 which is part of UK law
by virtue of the European Union (Withdrawal) Act 2018.
ReNeuron Group plc
("ReNeuron" or "the Company")
Interim Results for the six months ended 30 September 2022
ReNeuron Group plc (AIM: RENE), a UK based leader in Stem Cell
derived Exosome Technologies, announces its unaudited interim
results for the six months ended 30 September 2022 and a funding
update.
Catherine Isted, Chief Executive Officer, said: "The last six
months have been a time of transition as the executive team has
focused on accelerating the development of CustomEx(TM) our exosome
drug delivery platform. The data produced to validate the platform,
following Dr. Corteling's return in March of this year, has enabled
us to highlight the potential of CustomEx(TM) in comparison to the
conventional approach of our competitors. Following my appointment
as CEO in September, I have further strengthened the executive team
with the recent appointment of Simon Dew as Chief Business Officer.
In light of current unfavourable equity capital markets, it has not
been possible to complete an equity raise at the present time.
However, through a review of the cost base and planned initiatives,
savings have been identified in order to extend our cash runway to
ensure the continued development of our technology platform and
maximise partnering opportunities and thereby deliver the value
that I believe our customisable and targeted delivery platform
should command ."
FINANCIAL HIGHLIGHTS
-- Revenue for the period of GBP438,000 (H1 2021: GBP58,000)
related to income from partner funded development activities and
royalty income
-- Reduced operating costs incurred in the period of GBP4.7
million (H1 2021: GBP6.1 million) primarily as a result of a
reduction in clinical trial related costs following the strategic
review in January 2022, partly offset by additional investment made
in the exosome technology platform
-- Loss for the period of GBP3.2 million (H1 2021: loss of
GBP5.2 million) driven by lower costs, increased revenue as noted
above and foreign exchange gains
-- Net cash used in operating activities of GBP4.3 million (H1
2021: GBP4.6 million). Cash used was higher than the loss for the
period explained by changes in working capital and capital
investment made to support exosome platform development
-- Cash, cash equivalents and bank deposits at 30 September 2022
of GBP10.5 million (31 March 2022: GBP14.5 million)
FUNDING UPDATE
The Company has been investigating an equity raise with
institutional and other investors. Having regard to the
unfavourable conditions in small-cap equity markets, the Board has
concluded that it will not be possible to complete an equity raise
at the current time. As at 30 November 2022, having recently
received the R&D tax credit for FY 2022, the Company has cash
of GBP10.0 million, and through deferring certain expenditure on
proprietary programmes and other longer term development plans, the
cash runway will be extended until at least the start of the fourth
calendar quarter of 2023. This is not expected to compromise the
Company's ability to sign commercial exosome collaborations which
upon completion should extend the runway until at least 2024.
OPERATIONAL HIGHLIGHTS
Corporate and Organisational Development
In September 2022 the Company announced a number of organisation
changes:
-- Catherine Isted was appointed Chief Executive Officer with
Iain Ross resuming his role as Non-Executive Chairman
-- John Hawkins was promoted to Chief Financial Officer and joined the ReNeuron board;
-- Dr. Randolph Corteling assumed the role of Chief Scientific Officer
-- Suzanne Hancock was appointed Chief Operations officer
-- It was announced that Simon Dew , an experienced business
development professional and exosomes expert would join ReNeuron as
Chief Business Officer
Exosomes platform
-- Data presented in May highlighted the breadth of the Group's
CustomEx(TM) exosome platform with four neural and three non-neural
stem cell lines each producing distinct exosome populations
-- Post period end in October, the Group presented exciting data
on the significant advantages of its CustomEx(TM) platform,
including a 600% increase in delivery of siRNA compared to a
conventional human embryonic kidney-derived ("HEK") exosome
approach
Fosun Pharma
-- In July 2022, a Supplemental Terms Agreement was signed with
Fosun Pharma for the Technology Transfer of CTX into China,
highlighting continued progress with the collaboration
-- The Group expects to receive approximately GBP1 million over
the 24 month period from signing the agreement, of which GBP320,000
has been received. In addition there is potential under the
Technology Transfer agreement for the Group to receive up to GBP5
million over the medium to long term, with further potential
milestone payments of up to GBP74 million linked to the main
agreement signed in 2019
Enquiries:
ReNeuron www.reneuron.com/investors
Catherine Isted, Chief Executive Via Walbrook PR
Officer
John Hawkins, Chief Financial Officer
Liberum Capital Limited (NOMAD
and Joint Broker)
Phil Walker (Investment Banking)
Richard Lindley (Investment Banking)
Ben Cryer (Investment Banking) +44 (0)20 3110 2000
Allenby Capital Limited (Joint
Broker) +44 (0)20 3328 5656
James Reeve/George Payne (Corporate
Finance)
Stefano Aquilino (Sales & Corporate
Broking)
Walbrook PR (Media & Investor +44 (0)20 7933 8780 or reneuron@walbrookpr.com
Relations)
Alice Woodings +44 (0)7407 804 654
About ReNeuron
ReNeuron is a UK based leader in proprietary stem cell derived
exosome technologies, harnessing its unique stem cell technologies
to develop 'off the shelf' treatments for diseases with significant
unmet needs.
ReNeuron's stem cell derived proprietary exosome technology
platform offers a delivery mechanism for a variety of payloads such
as siRNA, mRNA, proteins, small molecules and genes. The Group has
a growing number of partner collaborations with Global Pharma,
Biotech and academic partners in this fast-expanding area of
scientific and commercial interest. ReNeuron also has the ability,
through its conditionally immortalised induced pluripotent stem
cell (iPSC) platform, to make allogeneic tissue cells of choice and
has the potential to produce exosomes with tissue specific
targeting ability.
The Group has out-licenced its CTX Programme for stroke
disability and hRPC programme in retinitis pigmentosa to Fosun in
China and is looking to out-license both of these programmes in
other territories.
ReNeuron's shares are traded on the London AIM market under the
symbol RENE.L. For further information visit www.reneuron.com
This announcement contains forward-looking statements with
respect to the financial condition, results of operations and
business achievements/performance of ReNeuron and certain of the
plans and objectives of management of ReNeuron with respect
thereto. These statements may generally, but not always, be
identified by the use of words such as "should", "expects",
"estimates", "believes" or similar expressions. This announcement
also contains forward-looking statements attributed to certain
third parties relating to their estimates regarding the growth of
markets and demand for products. By their nature, forward-looking
also statements involve risk and uncertainty because they reflect
ReNeuron's current expectations and assumptions as to future events
and circumstances that may not prove accurate. A number of factors
could cause ReNeuron's actual financial condition, results of
operations and business achievements/performance to differ
materially from the estimates made or implied in such
forward-looking statements and, accordingly, reliance should not be
placed on such statements.
INTERIM RESULTS FOR THE SIX MONTHSED 30 SEPTEMBER 2022
CHAIRMAN'S STATEMENT
Following the departure of our CEO in February 2022, I started
this financial year as Executive Chairman and had the opportunity
to spend a lot of time with the team at our site in Pencoed in
Wales. I have been impressed by the quality of the management team,
the science and the data produced by our scientists on our exosome
delivery platform CustomEx(TM) . In August, at my recommendation,
we announced that the board had taken the decision to appoint
Catherine Isted, our then CFO, as the new CEO having shown herself,
against external competition, to be an excellent candidate for the
role and that I would revert to being non-executive Chairman after
a period supporting the transition.
During September, under Catherine's leadership, we announced
that John Hawkins, our Financial Controller, would step up to the
role of CFO and join the board. Along with other executive changes
and the recruitment of Simon Dew as Chief Business Officer this now
completes what I believe to be a very strong executive team with
the skill sets needed to continue and accelerate the turnaround
following the change of strategic direction we as a board made
under my direction at the start of the year.
In summary the first six months of the financial year have been
a time of change with the transition to becoming a company with a
fully focused Exosomes drug delivery platform - CustomEx(TM) . The
Company has produced significant data highlighting the advantages
of the CustomEx(TM) platform over the competition's conventional
HEK based exosome delivery approach.
Progress has also been made with Fosun Pharma as we continue to
maximise the value of the legacy stem cell assets. Whilst
continuing to support Fosun in Greater China, we are also committed
to continuing to add value from the legacy assets and realising the
potential of the iPSC platform, not only in its role in future
proofing the CustomEx(TM) platform and its ability to generate new
exosome lines, but also in its own right. We will continue to
assess all opportunities to create value through organic growth but
also, as appropriate, explore technology licensing and acquisition
opportunities to accelerate and enhance the overall value
proposition of our Company.
The Group ended the period with cash, cash equivalents and bank
deposits of GBP10.5 million and with our cash runway being extended
until at least the start of the fourth calendar quarter 2023 and
the right team now in place, the Company will look to build on
these foundations and sign new longer-term commercial partnerships
to further extend the cash runway and therefore deliver value
commensurate with what our CustomEx(TM) platform can offer in the
field of targeted drug delivery.
I look forward to the coming year continuing to work with the
ReNeuron team and all our stakeholders to build the value this
Company truly merits.
Iain Ross
Chairman
CHIEF EXECUTIVE'S REPORT
Corporate and Organisational Development
There have been significant changes during the period at the
Executive level in addition to the changes at Directorate as
described in the Chairman's statement.
In September it was announced that Simon Dew would be joining
the Executive Team as Chief Business Officer. Mr. Dew is a senior
healthcare executive with extensive experience in Business
Development and Corporate Strategy. His career spans working at
SmithKline Beecham, IQVIA, Astellas Pharma, Gyroscope, and more
recently exosomes company Evox Therapeutics, where he was
responsible for leading two transformational partnership deals with
global pharmaceutical companies. He commenced his new role at
ReNeuron in early November.
Additionally, in September Dr. Randolph Corteling assumed the
role of Chief Scientific Officer with Prof. Stefano Pluchino moving
to the role of Chair of the Scientific Advisory Board (continuing
to combine working with ReNeuron with his academic work in Exosomes
and Regenerative Neuroimmunology at the University of Cambridge)
and Suzanne Hancock, formerly Head of Operations, moved to the
position of Chief Operations Officer.
CustomEx(TM) Exosome Platform
In the last six months there has been significant data presented
on ReNeuron's CustomEx(TM) platform, highlighting not only the
breadth of the platform but also improvements in uptake and payload
delivery when compared to the standard HEK based exosome
approach.
In May, Dr. Corteling was invited as a guest speaker to the
International Society of Cell and Gene Therapy conference. This
presentation was the first time that the Company had highlighted
the breadth of the Group's exosome platform, showing that it had
four district neural cell lines (in the cortex, hippocampus,
striatum and mesencephalon) in addition to three non-neural cell
lines (in the retina, liver and pancreas), with, very importantly,
each cell line producing a distinct exosomes type allowing for
improved target selection. In addition, ReNeuron highlighted its
induced pluripotent stem cell (iPSC) platform, derived from
ReNeuron's CTX cell line, which could be used to produce other stem
cell lines which in turn could be used to produce other distinct
exosomes depending on the target required.
In October, further exciting data were presented at an
international exosomes conference in Boston showing the significant
advantages of the Group's stem cell derived platform CustomEx(TM)
compared to a conventional HEK exosome approach. Key highlights
from the presentation included:
-- When comparing the uptake of a panel of exosomes into three
different target cell types (Epithelial cells, Endothelial cells
and Neural cells), ReNeuron identified one or more CustomEx(TM)
exosome types that outperformed the conventional approach of using
HEK-derived exosomes at least 10-fold in each of the three
different cell types. This was most pronounced with endothelial
cells where one of ReNeuron's CustomEx(TM) exosome types showed an
18-fold improvement in uptake over HEK-derived exosomes.
-- When ReNeuron's exosomes were loaded with an siRNA payload,
this improvement in uptake was reflected in the siRNA delivery to
the target cell, with the best performing CustomEx(TM) exosome type
showing a 600% improvement in siRNA delivery to the target cell
when compared to delivery from HEK-derived exosomes.
The siRNA data was of particular interest to ReNeuron's siRNA
collaborators, and the Group plans to further bolster its siRNA
data package over the coming period, highlighting the advantages of
using CustomEx(TM) .
During the period, ReNeuron continued to progress its existing
partner programmes focusing on the CNS, although following the
recent data announcements, interest has now started to grow outside
of the CNS. Additionally, the Group has received interest from
potential partners following presentation of these platform data.
The management team is working to progress both existing and
potential new partnerships towards meaningful collaborations over
the course of the next 12 months. The Group believes that the
addition of Simon Dew will help accelerate interest from the
industry which will ultimately lead to an acceleration of
partnering announcements.
Induced Pluripotent Stem Cell (iPSC) Platform
While the iPSC platform is highly important to expanding the
breadth of the CustomEx(TM) platform due to its ability to create
new stem cell lines and therefore associated exosomes from those
lines, there is also a growing interest in the iPSC platform in its
own right due to iPSC's ability to differentiate into any other
form of cell. ReNeuron's iPSCs were developed from the Group's
conditionally immortalised CTX stem cell line and they retain the
immortalisation characteristics of the original CTX line. This
results in any new stem cell line derived from these iPSCs having
the benefit of being highly stable which is of increased interest
to third parties.
Work continues with two groups at University College London
("UCL"), firstly investigating the potential use of CTX derived
iPSC lines to generate CAR-T / CAR-NK cells and secondly with a
separate group at UCL investigating the ability to differentiate
into Schwann cells for potential use in peripheral nerve damage
repair. The Group plans to generate further data in the iPSC field
over the coming six months and additionally expand its numbers of
collaborators in the area.
Legacy assets
Fosun Pharma continues to develop CTX in stroke disability in
China following the out-licensing agreement signed with ReNeuron in
April 2019. In July 2022, ReNeuron announced that it had negotiated
and signed a supplemental terms agreement with Fosun. As a result,
the Group expects to receive approximately GBP1 million over the 24
month period from signing the agreement (including the GBP320,000
upfront payment received in January 2022) in relation to the
initial supply of CTX cell bank vials and services provided to
undertake the technology transfer, with up to a further GBP5
million receivable by the Group over the medium to longer term for
the continued provision of CTX cell bank vials to enable
manufacture by Fosun Pharma and with further potential milestone
payments of up to GBP74m linked to the main agreement signed in
2019.
Fosun Pharma is expanding its cell therapy portfolio to stem
cell platforms and ReNeuron CTX is one of the starting programmes.
A dedicated Fosun Pharma team has been established for the
technology transfer into China and the construction of a 20,000
square foot GMP facility to manufacture CTX is underway. The
signing of this Supplemental Terms Agreement underscores Fosun
Pharma's continued commitment to the CTX stroke disability
programme.
The collaboration with Fosun Pharma continues on track and the
Group continues to progress out-licensing opportunities for the CTX
programme in other geographies.
Following the cessation of the hRPC programme earlier in the
year, work has been ongoing to complete the data package that can
be made available to potential interested parties. This data
package is expected to be completed in Q4 2022. There has been some
early interest in this programme and the Group will accelerate
efforts to progress this once the data package is available.
Outlook
With the executive team now in place, the key focus over the
coming period for myself and the rest for the team will be data
generation and collaboration deals to further extend the cash
runway.
We are targeting to announce several larger scale exosome
collaborations from existing / new partners and to develop further
collaboration agreements with our iPSC platform. We also plan to
accelerate the number of partnering opportunities in the 'hopper'
through a greater focus on marketing of the advantages of the
CustomEx(TM) platform. This, I believe, will lead to further
success for the Company over the longer term.
Presenting further data highlighting the customisability and
targeted approach of the CustomEx(TM) platform and superiority over
HEK based approaches will be a key priority for the team over the
period as will a renewed focus on looking to further monetise the
legacy assets outside of the agreement with Fosun Pharma.
I look forward to leading the new exosome focused team, as
ReNeuron extends its presence and exosome collaborations,
maximising the opportunities ahead, as we deliver returns to
shareholders from the fast-growing field of exosome mediated drug
delivery.
Catherine Isted
Chief Executive Officer
FINANCIAL REVIEW
During the first half of the financial year, costs continued to
be closely controlled with spend primarily directed towards
progressing the Group's proprietary exosome platform. The Group is
investing in the exosome platform in order to capitalise on the
potential it sees in the exosomes field by adding value through its
existing and future new commercial collaborations. The total
comprehensive loss for the period reduced to GBP3.2 million (H1
2021: GBP5.2 million).
At 30 September 2022, the Group had cash, cash equivalents and
bank deposits of GBP10.5 million.
FINANCIAL HIGHLIGHTS Six months ended Six months ended Year ended
(GBP'000) 30 September 30 September 31 March2022
2022 2021
Revenue 438 58 403
----------------- ----------------- --------------
Total comprehensive
loss 3,176 5,234 9,689
----------------- ----------------- --------------
Operating expenses 4,712 6,128 11,631
----------------- ----------------- --------------
Net cash used in
operating activities 4,323 4,599 7,411
----------------- ----------------- --------------
Cash, cash equivalents
& bank deposits 10,464 17,418 14,548
----------------- ----------------- --------------
Revenue and Other Operating Income
In the six months to 30 September 2022, revenues, which related
to partner funded development activities were GBP393,000 (H1 2021:
GBPNil). Income related to royalty income, was GBP45,000 (H1 2021:
GBP58,000).
Operating expenses
Total operating expenses reduced in the period to GBP4.7 million
(H1 2021: GBP6.1 million).
This reduction in costs followed a review of programme
priorities and resource requirements, with the Group having made
the decision to primarily focus its resources on its proprietary
exosome platform.
Research and development (R&D) expenditure reduced to GBP2.9
million (H1 2021: GBP4.3million), primarily reflecting the
refocussing of activities as described above, together with
consequent cost reductions related to clinical development
activities.
General and administrative expenses declined in the period to
GBP1.7million (H1 2021: GBP1.8 million).
Finance income/expense
Finance income represented income received from the Group's cash
and investments and gains from foreign exchange, with losses from
foreign exchange shown in finance expense.
Finance income was GBP466,000 in the period (H1 2021:
GBP124,000). The current period included foreign exchange gains of
GBP429,000 (H1 2021: GBP112,000). In the current period, finance
expense solely comprised lease interest of GBP10,000 (2021:
GBP18,000).
The Group holds cash and investments in foreign currencies in
order to hedge against operational spend in those currencies. The
weakening of sterling during the period resulted in a relative
increase in valuation of the Group's foreign currency deposits.
Taxation
The taxation credit for the period of GBP0.6 million primarily
comprised an R&D tax credit (H1 2021: GBP0.7 million). The
amount of the R&D tax credit reduced in line with the reduction
in research and development spend.
Cash flow
Net cash used in operating activities in the period reduced to
GBP4.3 million (H1 2020: GBP4.6 million). This reduction in cash
used reflected the reduction in costs offset by an adverse working
capital movement (H1 2022 saw a GBP0.5 million reduction in working
capital, whereas H1 2021 had a GBP0.9 million increase).
The Group had cash, cash equivalents and bank deposits totalling
GBP10.5 million as of 30 September 2022 (31 March 2022: GBP14.5
million).
Statement of financial position
Non-current assets increased as the Company invested in
property, plant and equipment to aid further development of the
exosome analytics and manufacturing process.
Current assets include a Corporation tax receivable of GBP2.0
million comprising the amount due from R&D tax credits for the
full year ended 31 March 2022 plus the credit due for the current
period (30 September 2021: GBP2.6 million). This debtor was lower
than 2021 due to the reduction in research and development
expenditure.
Current liabilities primarily comprise trade and other payables
at GBP6.2 million which were GBP0.4 million lower than the same
period last year (30 September 2021: GBP6.6 million) and GBP0.7
million lower than at the last year end (31 March 2022: GBP6.9
million).
Non-current liabilities represented the lease liability relating
to the Company's premises. The lease liability reduced by GBP0.1
million during the period.
John Hawkins
Chief Financial Officer
INTERIM FINANCIAL STATEMENTS
Unaudited Consolidated Statement of Comprehensive Income
for the six months ended 30 September 2022
Six months Six months
ended ended Year ended
30 September 30 September 31 March
2022 2021 2022
Note GBP'000 GBP'000 GBP'000
------------- -------------
Revenue 4 438 58 403
Research and development costs (2,986) (4,340) (8,068)
General and administrative
costs (1,726) (1,788) (3,563)
Operating loss (4,274) (6,070) (11,228)
Finance income 6 466 124 195
Finance expense 7 (10) (18) (25)
-------------------------------- ----- ------------- -----------
Loss before income taxes (3,818) (5,964) (11,058)
Taxation 8 642 730 1,369
-------------------------------- ----- ------------- -----------
Loss and total comprehensive
loss for the period (3,176) (5,234) (9,689)
-------------------------------- ----- ------------- ------------- -----------
Loss and total comprehensive
loss attributable to equity
owners of the company (3,176) (5,234) (9,689)
-------------------------------- ----- ------------- ------------- -----------
Basic and diluted loss per
ordinary share 9 (5.6p) (9.2p) (17.0p)
-------------------------------- ----- ------------- ------------- -----------
Unaudited Consolidated Statement of Financial Position
as at 30 September 2022
30 September 30 September 31 March
2022 2021 2022
Note GBP'000 GBP'000 GBP'000
------------------------------- ----- ------------- ------------- ----------
Assets
Non-current assets
Property, plant and equipment 354 325 288
Right-of-use asset 10 331 423 373
Intangible assets 186 186 186
871 934 847
------------------------------- ----- ------------- ------------- ----------
Current assets
Trade and other receivables 456 517 536
Corporation tax receivable 2,036 2,565 1,392
Investments - bank deposits 1,000 6,000 5,000
Cash and cash equivalents 9,464 11,418 9,548
-------------
12,956 20,500 16,476
------------- -------------
Total assets 13.827 21,434 17,323
------------------------------- ----- ------------- ------------- ----------
Equity
Equity attributable to owners
of the company
Share capital 11 571 569 571
Share premium account 11 113,925 113,925 113,925
Capital redemption reserve 40,294 40,294 40,294
Merger reserve 2,223 2,223 2,223
Accumulated losses (149,931) (142,858) (147,125)
Total equity 7,082 14,153 9,888
------------------------------- ----- ------------- ------------- ----------
Liabilities
Current Liabilities
Trade and other payables 6,249 6,646 6,873
Lease liabilities 151 145 146
6,400 6,791 7,019
------------------------------- ----- ------------- ------------- ----------
Non-current liabilities
Lease liabilities 345 490 416
345 490 416
------------------------------- ----- ------------- ------------- ----------
Total liabilities 6,745 7,281 7,435
Total equity and liabilities 13,827 21,434 17,323
------------------------------- ----- ------------- ------------- ----------
Unaudited Consolidated Statement of Changes in Equity
for the six months ended 30 September 2022
Share Capital
Share premium redemption Merger Accumulated Total
capital account reserve reserve losses Equity
GBP'000 GBP'000 GBP'000 GBP'000 GBP'000 GBP'000
-------- -------- ----------- -------- ------------ --------
As at 1 April 2021 569 113,904 40,294 2,223 (138,085) 18,905
Exercise of employee
share options - 21 - - - 21
Credit on share-based
payment - - - - 461 461
Loss and total comprehensive
loss for the period - - - - (5,234) (5,234)
As at 30 September
2021 569 113,925 40,294 2,223 (142,858) 14,153
Exercise of employee
share options 2 - - - - 2
Credit on share-based
payment - - - - 188 188
Loss and total comprehensive
loss for the period - - - - (4,455) (4,455)
As at 31 March 2022 571 113,925 40,294 2,223 (147,125) 9,888
Credit on share-based
payment - - - - 370 370
Loss and total comprehensive
loss for the period - - - - (3,176) (3,176)
As at 30 September
2022 571 113,925 40,294 2,223 (149,931) 7,082
------------------------------ -------- -------- ----------- -------- ------------ --------
Unaudited Consolidated Statement of Cash Flows
for the six months ended 30 September 2022
Six months Six months
ended ended Year ended
30 September 30 September 31 March
2022 2021 2022
Note GBP'000 GBP'000 GBP'000
-------------------------------- ----- ------------- ------------- -----------
Cash flows from operating
activities
Cash used in operations 12 (4,310) (4,578) (9,196)
Overseas taxes paid (3) (3) (52)
Income tax credit received - - 1,862
Interest paid (10) (18) (25)
Net cash used in operating
activities (4,323) (4,599) (7,411)
Cash flows from investing
activities
Capital expenditure (156) (238) (302)
Interest received 32 3 26
------------- ------------- -----------
Net cash (used in)/generated
by investing activities (124) (235) (276)
Cash flows from financing
activities
Proceeds from the issue of
ordinary shares - 21 23
Bank deposits matured/(placed) 4,000 1,500 2,500
Lease payments (73) (84) (157)
Lease finance 7 - -
Net cash generated by/(used
in) financing activities 3,934 1,437 2,366
-------------------------------- ----- ------------- ------------- -----------
Net (decrease)/increase in
cash and cash equivalents 13 (513) (3,397) (5,321)
Effect of foreign exchange
rates 429 112 166
Cash and cash equivalents
at the start of period 9,548 14,703 14,703
Cash and cash equivalents
at the end of period 14 9,464 11,418 9,548
-------------------------------- ----- ------------- ------------- -----------
Notes to the Interim Financial Statements
for the six months ended 30 September 2022
1. General information and basis of preparation
ReNeuron Group plc is an AIM listed company incorporated and
domiciled in the United Kingdom under the Companies Act 2006. The
Company's registered office and its principal place of business is
Pencoed Business Park, Pencoed, Bridgend CF35 5HY. Its shares are
listed on the Alternative Investment Market ("AIM") of the London
Stock Exchange.
These Interim Financial Statements were prepared by the
Directors and approved for issue on xx xxx 2022. They have not been
audited.
These Interim Financial Statements do not comprise statutory
accounts within the meaning of section 434 of the Companies Act
2006. Statutory accounts for the year ended 31 March 2022 were
approved by the Board of Directors on 11 August 2022 and delivered
to the Registrar of Companies. The report of the auditors on those
accounts was unqualified and did not contain statements under 498
(2) or (3) of the Companies Act 2006. The auditor's report did
however contain an emphasis of matter regarding a material
uncertainty related to going concern.
As permitted, these Interim Financial Statements have been
prepared in accordance with UK AIM rules and with International
Accounting Standard 34 "Interim financial reporting". They should
be read in conjunction with the Annual Financial Statements for the
year ended 31 March 2022, which have been prepared in accordance
with International Accounting Standards in conformity with the
Companies Act 2006 (IFRS) and the applicable legal requirements of
the Companies Act 2006.
2. Accounting policies
The accounting policies applied are consistent with those of the
Annual Financial Statements for the year ended 31 March 2022, as
described in those Annual Financial Statements. Where new standards
or amendments to existing standards have become effective during
the year, there has been no material impact on the net assets or
results of the Group.
3. Going concern
The Group is expected to incur further costs as it continues to
develop its technologies through the research and pre-clinical
development pathway. The operations of the Group are currently
being financed from funds that have been raised from share
placings, commercial partnerships and grants.
The Group actively seeks further business development and
commercial opportunities in order to support its ongoing
development programmes. The Board places considerable emphasis on
communication with shareholders, potential investors and other
commercial organisations in order to maximise the chances of
success in exploiting these opportunities.
As noted previously, it has not been possible to complete an
equity raise at this current time. The Board will continue to
explore alternative funding mechanisms and note that in the absence
of any further financing, the Group's current financial resources
will be sufficient to support operations until at least the start
of the fourth calendar quarter 2023.The Board therefore considers
it appropriate to continue to adopt the going concern basis in the
preparation of these interim financial statements. However, there
is no guarantee that future attempts to secure adequate additional
revenues/funding on a timely basis will be successful and,
therefore, this represents a material uncertainty, which may cast
significant doubt about the Group's ability to continue as a going
concern. These interim financial statements do not include the
adjustments that would result if the Group were unable to continue
as a going concern.
4. Revenue
Six months Six months
Ended Ended Year ended
30 September 30 September 31 March
2022 2021 2022
GBP'000 GBP'000 GBP'000
Royalty income 45 58 119
Income associated with development activities 393 - 284
---------------------------------------------- ------------ ------------- -----------
438 58 403
---------------------------------------------- ------------ ------------- -----------
Royalty income is derived from the licensed sale of the Group's
products to customers in the USA.
Income associated with development activities relates to fees
received under research agreements and is generated in the United
Kingdom, the USA, the People's Republic of China and South East
Asia.
5. Segment information
The Group has identified the Chief Executive Officer as the
Chief Operating Decision Maker (CODM). The CODM manages the
business as one segment, the development of stem cell derived
exosome technologies. Since this is the only reporting segment, no
further information is included. The information used internally by
the CODM is the same as that disclosed in the Interim Financial
Statements. Revenue is analysed in note 4 above.
6. Finance income
Six months Six months
Ended Ended Year ended
30 September 30 September 31 March
2022 2021 2022
GBP'000 GBP'000 GBP'000
----------------------- ------------ ------------- -----------
Interest received 37 12 29
Foreign exchange gains 429 112 166
----------------------- ------------ ------------- -----------
466 124 195
----------------------- ------------ ------------- -----------
7. Finance expense
Six months Six months
Ended Ended Year ended
30 September 30 September 31 March
2022 2021 2022
GBP'000 GBP'000 GBP'000
--------------- ------------ ------------- -----------
Lease interest 10 18 25
10 18 25
--------------- ------------ ------------- -----------
8. Taxation
Six months Six months
Ended Ended Year ended
30 September 30 September 31 March
2022 2021 2022
GBP'000 GBP'000 GBP'000
-------------------------------------- ------------ ------------- -----------
R & D tax credit 644 733 1,392
Overseas taxation (2) (3) (53)
Adjustments in respect of prior years - - 30
642 730 1,369
-------------------------------------- ------------ ------------- -----------
9. Basic and diluted loss per share
The basic and diluted loss per share is calculated by dividing
the loss for the financial period of GBP3,176,000 (September 2021:
GBP5,234,000, March 2022: GBP9,689,000) by 57,090,147 shares
(September 2021: 56,907,676 and March 2022: 56,975,677 shares),
being the weighted average number of ordinary 1p shares in issue
during the period. Potential ordinary shares are not treated as
dilutive as the entity is loss-making.
10. Right-of-use-asset
30 September 30 September 31 March
2022 2021 2022
GBP'000 GBP'000 GBP'000
--------------------------- ------------ ------------- ---------
At beginning of the period 373 473 473
Additions 7 - -
Depreciation charge (49) (50) (100)
At end of the period 331 423 373
--------------------------- ------------ ------------- ---------
The net book value of the underlying assets is as follows:
30 September 30 September 31 March
2022 2021 2022
(124)461 GBP'000 GBP'000 GBP'000
------------------------------ ------------ ------------- ---------
Land and buildings 325 421 373
Computer and office equipment 6 2 -
At end of the period 331 423 373
------------------------------ ------------ ------------- ---------
11. Share capital and share premium
Number Share Share premium Total
of shares capital
GBP'000 GBP'000 GBP'000
---------------------------- ---------- --------- ------------- -------
As at 30 September 2021 56,936,402 569 113,925 114,494
Issue of new shares - share
options exercised 127,221 2 - 2
---------------------------- ---------- --------- ------------- -------
As at 31 March 2022 57,063,623 571 113,925 114,496
Issue of new shares - share
options exercised 82,270 - - -
As at 30 September 2022 57,145,893 571 113,925 114,496
---------------------------- ---------- --------- ------------- -------
12. Cash used in operations
Six months Six months
Ended Ended Year ended
30 September 30 September 31 March
2022 2021 2022
GBP'000 GBP'000 GBP'000
-------------------------------------- ------------ ------------- -----------
Loss before income tax (3,818) (5,964) (11,058)
Adjustment for:
Finance income (466) (124) (195)
Finance expense 10 18 25
Depreciation of property, plant and
equipment 83 126 224
Depreciation of right-of-use asset 49 50 100
Loss on disposal of fixed assets - - 3
Share-based payment charges 370 461 649
Changes in working capital:
Receivables 87 (64) (90)
Payables (625) 919 1,146
-------------------------------------- ------------ ------------- -----------
Cash used in operations (4,310) (4,578) (9,196)
-------------------------------------- ------------ ------------- -----------
13. Reconciliation of net cash flow to movement in net debt
Six months Six months
Ended Ended Year ended
30 September 30 September 31 March
2022 2021 2022
GBP'000 GBP'000 GBP'000
----------------------------------------------- ------------ ------------- -----------
Decrease in cash and cash equivalents (513) (3,397) (5,321)
Effect of foreign exchange rates 429 112 166
Cash inflow from increase in lease liabilities (7) - -
Lease repayments 83 102 182
Lease interest (10) (18) (25)
Net funds at start of period 8,986 13,984 13,984
Net funds at end of period 8,968 10,783 8,986
----------------------------------------------- ------------ ------------- -----------
14. Analysis of net funds
Six months Six months
Ended Ended Year ended
30 September 30 September 31 March
2022 2021 2022
GBP'000 GBP'000 GBP'000
-------------------------- ------------ ------------- -----------
Cash and cash equivalents 9,464 11,418 9,548
Lease liabilities (496) (635) (562)
Net funds 8,968 10,783 8,986
-------------------------- ------------ ------------- -----------
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END
IR FFFLIFVLLIIF
(END) Dow Jones Newswires
December 02, 2022 02:00 ET (07:00 GMT)
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