DEFENCE THERAPEUTICS CANCER VACCINE ACCUVAC-D001 MANUFACTURING TARGETS MELANOMA AND BREAST CANCER

DEFENCE THERAPEUTICS CANCER VACCINE ACCUVAC-D001 MANUFACTURING TARGETS MELANOMA AND BREAST CANCER

Vancouver, BC, Canada -- November 23, 2021 -- InvestorsHub NewsWire -- Defence Therapeutics Inc. ("Defence" or the "Company"), a biotechnology company working on cancer therapeutics and infectious disease vaccines is pleased to announce the establishment of an agreement with the Lady Davis Institute cell processing center (CPC) to initiate manufacturing of its AccumTM DC cancer vaccine candidate AccuVAC-D001. This agreement immediately positions Defence's vaccine to be manufactured with the focus on melanoma and breast cancer.

The mandate of the Jewish General Hospital CPC located at the Lady Davis Institute is to support early phase clinical trials of cell-based therapies where processing of human cell and tissue is required to treat human catastrophic illnesses such as cancer. The close proximity of this facility to hospital patients further simplifies the logistics of the trial.

The facility comprises of the Clean Room area where cell processing takes place, as well as the Laboratory Annex supporting the Clean Room. The Clean Room is a clinical-grade, high sterility isolation facility certified ISO Class 7. It is operated by highly qualified personnel led by Dr. Nicoletta Eliopoulos, a pioneer in cell therapy with a track record of successful implementation and prosecution of custom autologous cellular pharmaceuticals.

"We are a step closer to initiate our Phase I trial using our proprietary AccumTM DC technology with the establishment of such agreement. These studies will not only establish the "blueprints" of our manufacturing process, but they will implement import quality control steps required by regulatory agencies prior to treating melanoma and breast cancer patients in 2022", says Mr. Plouffe, CEO of Defence Therapeutics.

About Defence:

Defence Therapeutics is a publicly-traded biotechnology company working on engineering the next generation vaccines and ADC products using its proprietary platform. The core of Defence Therapeutics platform is the ACCUMTM technology, which enables precision delivery of vaccine antigens or ADCs in their intact form to target cells. As a result, increased efficacy and potency can be reached against catastrophic illness such as cancer and infectious diseases.

For further information:

Sebastien Plouffe, President, CEO and Director

P: (514) 947-2272

Splouffe@defencetherapeutics.com

www.defencetherapeutics.com

Cautionary Statement Regarding "Forward-Looking" Information

This release includes certain statements that may be deemed "forward-looking statements". All statements in this release, other than statements of historical facts, that address events or developments that the Company expects to occur, are forward-looking statements. Forward-looking statements are statements that are not historical facts and are generally, but not always, identified by the words "expects", "plans", "anticipates", "believes", "intends", "estimates", "projects", "potential" and similar expressions, or that events or conditions "will", "would", "may", "could" or "should" occur. Although the Company believes the expectations expressed in such forward-looking statements are based on reasonable assumptions, such statements are not guarantees of future performance and actual results may differ materially from those in the forward-looking statements. Factors that could cause the actual results to differ materially from those in forward-looking statements include regulatory actions, market prices, and continued availability of capital and financing, and general economic, market or business conditions. Investors are cautioned that any such statements are not guarantees of future performance and actual results or developments may differ materially from those projected in the forward-looking statements. Forward-looking statements are based on the beliefs, estimates and opinions of the Company's management on the date the statements are made. Except as required by applicable securities laws, the Company undertakes no obligation to update these forward-looking statements in the event that management's beliefs, estimates or opinions, or other factors, should change.

Neither the CSE nor its market regulator, as that term is defined in the policies of the CSE, accepts responsibility for the adequacy or accuracy of this release.

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