SECURITIES
AND EXCHANGE COMMISSION
Washington,
D.C. 20549
FORM
6-K
REPORT
OF FOREIGN PRIVATE ISSUER
PURSUANT
TO RULE 13a-16 OR 15d-163
UNDER
THE SECURITIES EXCHANGE ACT OF 1934
For
the month of February 2025
Alterity
Therapeutics Limited
(Name
of Registrant)
Level 14, 350 Collins Street,
Melbourne, Victoria 3000 Australia
(Address
of Principal Executive Office)
Indicate
by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F.
Form
20-F ☒ Form 40-F ☐
This
Form 6-K is being incorporated by reference into our Registration Statement on Form S-8 (Files No. 333-251073, 333-248980
and 333-228671) and our
Registration Statements on Form F-3 (Files No. 333-274816, 333-251647, 333-231417
and 333-250076)
ALTERITY
THERAPEUTICS LIMITED
(a
development stage enterprise)
The
following exhibits are submitted:
SIGNATURE
Pursuant
to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by
the undersigned, thereunto duly authorized.
| |
Alterity Therapeutics Limited |
| |
|
|
| |
By: |
/s/ Geoffrey P. Kempler |
| |
|
Geoffrey P. Kempler |
| |
|
Chairman |
Date:
February 28, 2025
2
Exhibit
99.1
Alterity
Therapeutics Limited
Appendix
4D
Half-year
ended 31 December 2024
| Name
of entity: |
Alterity
Therapeutics Limited |
| ABN: |
37
080 699 065 |
| Half-year
ended: |
31
December 2024 |
| Previous
period: |
31
December 2023 |
Results
for announcement to the market
| | |
| |
| | | |
| |
| A$ | |
| | |
| |
| | | |
| |
| | |
| Revenue
from ordinary activities | |
Down | |
| 6.0 | % | |
to | |
| 111,299 | |
| Net
loss after tax (from ordinary activities) for the period attributable to members | |
Up | |
| 10.2 | % | |
to | |
| 7,173,335 | |
| Net
loss after tax for the period attributable to members | |
Up | |
| 10.2 | % | |
to | |
| 7,173,335 | |
| Net
tangible assets per security | |
| |
| | | |
| |
| | |
| | |
| |
| | | |
| |
| | |
| | |
| |
| 31
December | | |
| |
| 31
December | |
| | |
| |
| 2024 | | |
| |
| 2023 | |
| | |
| |
| cents | | |
| |
| cents | |
| | |
| |
| | | |
| |
| | |
| Net
tangible asset backing (cents per share) | |
| |
| 0.14 | | |
| |
| 0.62 | |
Explanation
of results
Alterity
Therapeutics Limited recorded income of $111,299 for the half-year ended 31 December 2024 (2023: $118,400) which is interest received
on the Group’s bank accounts. Alterity Therapeutics Limited has incurred a loss of $7,173,335 for the half-year ended 31 December
2024 (2023: $6,507,183).
An
explanation of the key financial elements contributing to the revenue and result above can be found in the review of operations included
within the directors’ report.
Distributions
No
dividends have been paid or declared by the Group for the current financial period. No dividends were paid for the previous financial
period.
Changes
in controlled entities
There
have been no changes in controlled entities during the period ended 31 December 2024.
Other
information required by Listing Rule 4.2A
N/A
Interim
review
The
interim financial statements have been reviewed by the Group’s independent auditor.
Alterity
Therapeutics Limited
ABN
37 080 699 065
Interim
financial report for the
half-year
ended 31 December 2024
Alterity
Therapeutics Limited
Corporate
directory
| Directors |
|
Mr.
Geoffrey Kempler |
|
|
Chairman |
| |
|
|
|
|
Mr.
Brian Meltzer |
|
|
Independent
Non-Executive Director |
| |
|
|
|
|
Mr.
Peter Marks |
|
|
Independent
Non-Executive Director |
| |
|
|
|
|
Mr.
Lawrence Gozlan |
|
|
Non-Executive
Director |
| |
|
|
| Secretary |
|
Ms
Abby Macnish Niven (from 18 November 2024) |
| |
|
|
| |
|
Mr
Phillip Hains (to 17 November 2024) |
| |
|
|
| Principal
registered office in Australia |
|
Level
14, 350 Collins Street |
|
|
Melbourne
VIC 3000 |
| |
|
Australia |
|
|
+61
3 9349 4906 |
| |
|
|
| Share
register |
|
Automic
Pty Ltd |
|
|
Level
5, 191 St Georges Terrace |
|
|
Perth
WA 6000 |
|
|
1300
288 664 (within Australia) & +61 2 9698 5414 (outside Australia) |
| |
|
|
| Auditor |
|
PricewaterhouseCoopers |
|
|
2
Riverside Quay |
|
|
Southbank
Victoria 3006 |
| |
|
|
| Solicitors |
|
Quinert
Rodda & Associates Pty Ltd |
|
|
Level
6/400 Collins St |
| |
|
Melbourne
Victoria 3000 |
| |
|
|
| Website |
|
www.alteritytherapeutics.com |
Alterity
Therapeutics Limited
Directors’ report
31 December 2024
Your
directors present their report on the Consolidated Entity (referred to hereafter as the group) consisting of Alterity Therapeutics Limited
and the entities it controlled at the end of, or during, the half-year ended 31 December 2024.
Directors
The
following persons held office as directors of Alterity Therapeutics Limited during the whole of the half-year and up to the date of this
report:
Mr.
Geoffrey Kempler
Mr.
Brian Meltzer
Mr.
Peter Marks
Mr.
Lawrence Gozlan
Half
Yearly Review of Operations – 31 December 2024
Operations
Summary
In
the first half of FY25, Alterity delivered material progress on all aspects of its business.
Most
notably, subsequent to the end of the period, in January 2025, Alterity announced positive topline results from its lead clinical development
program in early-stage Multiple System Atrophy (MSA). The ATH434-201 randomised, double-blind Phase 2 clinical trial demonstrated a clinically
meaningful benefit at both ATH434 doses studied, achieving statistical significance at the 50 mg dose, with 48% slowing of clinical progression
on the modified UMSARS Part I rating scale (UMSARS I) that assesses disability on activities of daily living affected in MSA. In addition,
ATH434 demonstrated a favourable safety profile and key MRI biomarker data showed target engagement with reduced iron accumulation in
MSA affected brain regions.
In
the first half of FY25, Alterity also reported positive interim data from the ATH434-202 trial in participants with MSA who had advanced
disease compared to study ATH434-201. The interim analysis showed a benefit on the UMSARS I compared to historical data with clinical
responders demonstrating target engagement on MRI.
Numerous
data presentations were given at prominent medical meetings during the period featuring all of Alterity’s clinical and research
programs in MSA, Parkinson’s disease, and Friedreich Ataxia.
Based
on the promising ATH-434-201 clinical results, Alterity successfully raised additional funding with new investors and current shareholders
to accelerate ATH434 regulatory and clinical development activities, business development activities, and to continue research and discovery
of novel compounds for major indications such as Parkinson’s disease.
All
these advancements demonstrate Alterity’s ability to deliver on its clinical pipeline and corporate objectives as it strives to
develop the first disease modifying treatment for neurodegenerative disease.
Alterity’s
30 June 2024 Annual Report contains detailed background information relating to its operations, including its research and development
projects and collaboration partners, and should be read in conjunction with this report.
Progress
in Ongoing Clinical and Research Pipeline
Lead
Compound - ATH434
Discovered
internally, Alterity’s lead compound ATH434 is an oral agent designed to inhibit the aggregation of pathological proteins implicated
in neurodegeneration. ATH434 acts by redistributing excess iron in the brain, reducing the toxic accumulation of the protein α-synuclein,
and rescuing neuronal function. As an iron chaperone, ATH434 has the potential to address the underlying pathology of the disease and
preserve function in individuals with neurodegenerative diseases.
Based
on accumulated pre-clinical data and an understanding of how Parkinsonian disorders develop and progress, the Company believes ATH434
has excellent potential to treat MSA, Parkinson’s disease as well as Friedreich Ataxia.
Alterity
Therapeutics Limited
Directors’ report
31 December 2024
(continued)
Half
Yearly Review of Operations – 31 December 2024 (continued)
Based
on accumulated pre-clinical data and an understanding of how Parkinsonian disorders develop and progress, the Company believes ATH434
has excellent potential to treat MSA, Parkinson’s disease as well as Friedreich Ataxia.
ATH434
as a Potential Disease Modifying Treatment for Multiple System Atrophy (MSA)
Alterity
made substantial progress in the first half of FY25 advancing its clinical and research programs in the rare, orphan indication of MSA.
ATH434 has been granted Orphan Drug Designation (ODD) for the treatment of MSA by the U.S. FDA and the European Commission. ODD comes
with many benefits including 7-10 years of market exclusivity, tax credits and fee reductions, as well as protocol assistance from each
agency.
MSA
is a rare neurodegenerative disease, related to Parkinson’s disease, that progresses rapidly and causes profound disability. While
some of the symptoms of MSA can be treated with available medications, currently there are no drugs that can slow disease progression
and there is no cure. MSA is a Parkinsonian disorder characterised by a variable combination of slowed movement and/or rigidity, autonomic
instability that affects involuntary functions such as blood pressure maintenance and bladder control, and impaired balance and/or coordination
that predisposes to falls, all of which drastically impair quality of life.
The
pathological hallmark of MSA is accumulation of the protein α-synuclein and neuron loss in multiple regions within the central
nervous system. The symptoms reflect the progressive loss of function and death of different types of nerve cells in the brain and spinal
cord. Alterity’s clinical trials are evaluating the efficacy, safety and pharmacokinetics of ATH434 in individuals with MSA. This
includes clinical endpoints that assess MSA symptoms and biomarkers that evaluate target engagement and drug activity. The selected biomarkers,
such as brain iron on MRI, reflect MSA pathology and are therefore appropriate targets to assess drug activity.
ATH434
successfully completed Phase 1 studies demonstrating the agent is well tolerated and achieved brain levels comparable to efficacious
levels in animal models of MSA. Alterity has successfully completed its ATH434- 201 Phase 2 clinical trial and the ATH434-202 Phase 2
study is ongoing.
ATH434–201:
Randomised, Double-Blind, Placebo Controlled Phase 2 Clinical Trial in Early-State MSA
The
ATH434-201 Phase 2 clinical trial is a randomised, double-blind, placebo-controlled investigation of ATH434 in patients with early-stage
MSA. In addition to evaluating biomarkers and clinical scores on the UMSARS scale, wearable sensors were also employed to evaluate motor
activities that are important to patients with MSA. The study enrolled 77 adults who were randomly assigned to receive one of two dose
levels of ATH434 or placebo. Participants received treatment for 12 months.
On
4 December 2024, Alterity reported the completion of the ATH434-201 study as the last patient finished all clinical evaluations leading
to the announcement of the topline results. The completion of the trial represented a major accomplishment for Alterity in this rare
neurodegenerative disease.
In
October 2024, Alterity announced Dr. Stamler delivered an Oral Platform presentation and poster session at the International Congress
of Parkinson’s Disease and Movement Disorders® (MDS) entitled “A Phase 2 Study of ATH434, a Novel Inhibitor of α-Synuclein
Aggregation, for the Treatment of Multiple System Atrophy”. The oral presentation and poster described the baseline characteristics
for the 77 participants from Alterity’s ATH434-201 trial, with a focus on baseline fluid biomarkers, neuroimaging and clinical
data. The participants met strict selection criteria designed to confirm they had early-stage MSA. The presentation characterised the
distribution of iron in MSA affected brain areas and demonstrated that plasma levels of neurofilament light chain, a marker of neuronal
injury, were correlated with disease severity at baseline.
ATH434–202:
Open-label, Biomarker Phase 2 Clinical Trial in More Advanced MSA
The
ATH434-202 trial is evaluating participants with more advanced MSA as compared to the cohort from the 201 trial. While the 202 trial
is also treating participants for 12 months, it has an open label design that allowed Alterity to perform interim analyses of biomarker
and clinical data while the study is ongoing.
Alterity
Therapeutics Limited
Directors’ report
31 December 2024
(continued)
Half
Yearly Review of Operations – 31 December 2024 (continued)
In
October 2024, Alterity announced the presentation of positive interim data from the ATH434-202 trial as both a late-breaking oral presentation
and poster session entitled “Preliminary Efficacy and Safety of ATH434 in Multiple System Atrophy” at the MDS meeting. The
data suggest that ATH434 may have a disease-modifying effect in MSA, as 30% of participants had stable or improved clinical outcomes
(clinical responders). Disease progression over 6 months was slower compared to a historical group of untreated MSA patients, as indicated
by the Unified MSA Rating Scale (UMSARS) Part I which assesses functional performance. The clinical responders had stable brain iron
and brain volume after 12 months treatment. The stabilisation of iron content in MSA affected brain regions, combined with stable levels
of NfL, indicates that ATH434 may slow neurodegeneration by modulating brain iron levels and reducing oxidative injury.
On
17 July 2024, Alterity reported positive interim data from the ATH434-202 trial. The preliminary analysis included clinical, biomarker
and neuroimaging data. After 6 months of treatment, 43% of participants showed improvement on the UMSARS I compared to historical data.
In addition, the clinical responders on average had reduced accumulation of iron on brain MRI demonstrating target engagement compared
to participants who declined.
The
trial remains ongoing with topline 12-month results expected in the second quarter of calendar year 2025.
ATH434
for the Treatment of Parkinson’s Disease
In
October 2024, a poster was presented at MDS entitled “Effects of ATH434, a Clinical-Phase Small Molecule with Moderate Affinity
for Iron, in Hemiparkinsonian Macaques”. The presentation demonstrated that ATH434 treatment improved motor performance and general
function in monkeys with experimentally induced Parkinson’s disease and that improvement was associated with normal or reduced
levels of iron in the affected area of the brain, the substantia nigra. At week 12, all 5 ATH434-treated macaques had stable or improving
scores from Baseline while two of three vehicle-treated macaques did not demonstrate improvement. The improved general behavior was well-
correlated with reduced motor impairment. These favorable Parkinsonian outcomes observed in each of the ATH434-treated monkeys were also
associated with increased levels of striatal synaptophysin, a protein marker that reflects functional connections between neurons, suggesting
functional recovery of nerve endings in this critical motor pathway. These results support further investigation of ATH434 for the treatment
of Parkinson’s disease.
Peer-reviewed
Publication Describing Novel Mechanism of Action for ATH434
In
November 2024, the peer-reviewed journal Metallomics published data on the importance of iron and iron- targeting agents like
ATH434 to treat neurodegenerative diseases. The publication, entitled “ATH434, a promising iron-targeting compound for treating
iron regulation disorders”, demonstrates the novel way in which ATH434 targets the labile, or reactive, form of iron which can
be so damaging to cells when in excess. The iron binding properties of ATH434 presented in the publication support the characterization
of ATH434 as an iron chaperone. The publication also describes how ATH434 targets the toxic form of iron that drives the pathology of
a rare neurodegenerative disease known as Friedreich’s Ataxia. This toxic form of iron is also involved in the pathogenesis of
Parkinson’s disease and MSA.
Non-Clinical
Data Describing Neuroprotection of ATH434
In
October 2024, promising new data related to ATH434 were presented at the Society for Neuroscience 2024 that further the understanding
of ATH434’s potential as a disease modifying treatment for neurodegenerative diseases, including Parkinson’s disease and
related disorders. The poster presentation, entitled “Potent Antioxidant and Mitochondrial-protectant Effects of ATH434, a Novel
Inhibitor of α-Synuclein Aggregation with Moderate Iron- binding Affinity,” demonstrated that the neuroprotective and mitochondrial
protectant properties of ATH434 include reducing lipid damage in two distinct and disease-relevant neuronal injury models. ATH434’s
antioxidant properties were distinguished from those of another iron binding agent approved for treating iron overload.
This
is key as oxidative injury is an important contributor to the pathology of neurodegeneration. By addressing this injury in two different
ways, both directly and by redistributing excess labile iron, ATH434 has excellent potential to treat this group of diseases. The ability
of ATH434 to reduce damage to lipid membranes undergoing oxidative stress may augment its ability to slow disease progression.
Alterity
Therapeutics Limited
Directors’ report
31 December 2024
(continued)
Half
Yearly Review of Operations – 31 December 2024 (continued)
bioMUSE
Natural History Study in MSA
The
“Biomarkers of progression in Multiple System Atrophy” (bioMUSE) natural history study has generated invaluable data related
to understanding MSA and its early presentation, tracking the progression of individuals with MSA, and characterising MSA in terms of
various biomarkers. This study demonstrates that Alterity is leading the way in evaluation of this rare disease, and findings from the
study have de-risked Alterity’s Phase 2 studies by improving the diagnostic accuracy of enrolled MSA patients, thus giving ATH434
the best chance of success.
In
November 2024, data was presented at the 35th International Symposium on the Autonomic Nervous System that highlighted Alterity’s
work to better understand not only how MSA initially presents, but also how it progresses over time. The platform presentation, entitled
“The MSA Atrophy Index: A Marker of Clinical Progression in Multiple System Atrophy”, described the use of state-of-the-art
technology that goes beyond traditional MRI methods to track the change in volume in specific regions of the brain affected in patients
with MSA. Importantly, it was observed that significant reductions in brain volume over 12 months correlated with clinical worsening
of the disease. The results underscore the importance of utilizing advanced neuroimaging and analytical methods in evaluating MSA.
In
October 2024, Alterity announced that a poster featuring bioMUSE data was presented at MDS, entitled “Association Between Clinical
Progression in Multiple System Atrophy and Brain Volume Changes Evaluated via Deep Learning Segmentation”. The poster described
the novel MRI imaging techniques and deep learning segmentation methods that were used to assess brain volume in MSA brain regions of
interest (ROI) in bioMUSE participants. Over the course of one year, significant brain volume reduction was observed in MSA ROIs whereas
Parkinson’s disease patients showed no significant changes in brain volume. The results illustrate the correlation between the
brain volume reduction and worsening clinical scores, as measured by the UMSARS, providing the basis for subcortical brain volume as
a potential biomarker in treatment studies.
Corporate
Activity
During
the period, management participated in several investor activities and Alterity was featured in multiple media articles.
On
18 November 2024, Alterity appointed Abby Macnish Niven, CFA as Alterity’s Company Secretary following her appointment as Chief
Financial Officer of Alterity on 30 September 2024. Ms Macnish Niven has extensive experience in private wealth management and consults
to a range of listed and unlisted companies in governance, finance and corporate structures.
On
22 November 2024, Alterity held its Annual General Meeting in Melbourne, Australia.
Key
subsequent event: Based on the promising results from the ATH434-201 study, in February 2025, Alterity strengthened its balance sheet
by raising approximately A$42 million with new investors and current shareholders. The successful financing combined the use of its at-the-market
(ATM) facility in the U.S. (A$2.13 million received on 04 February 2025) and a Two-Tranche Placement: A$12.8 million raised in Tranche
One (received in mid- February 2025), and Tranche Two of the Placement is expected to raise approximately A$27.2 million, subject to
shareholder approval at an EGM anticipated to take place at the end of March 2025. The monies will be used to accelerate ATH434 regulatory
and clinical development activities, business development activities, and continue research and discovery of novel compounds for major
indications such as Parkinson’s disease.
Significant
changes in the state of affairs
There
have been no significant changes in the state of affairs of the Group during the period.
Events
since the end of the financial year
As
per the details on the Corporate Activity section on page 5, Alterity strengthened its balance sheet by raising approximately
A$42 million with new investors and current shareholders.
Alterity
Therapeutics Limited
Directors’ report
31 December 2024
(continued)
Half
Yearly Review of Operations – 31 December 2024 (continued)
Apart
from the events occurring after the reporting period, as disclosed in Note 12, there are no other significant matters or circumstances
arisen since 31 December 2024 that have significantly affected the Group’s operations, results or state of affairs, or may do so
in future periods.
Auditor’s
independence declaration
A
copy of the auditor’s independence declaration as required under section 307C of the Corporations Act 2001 is set out on
the following page.
Rounding
of amounts
The
company is of a kind referred to ASIC Legislative Instrument 2016/191, relating to the ‘rounding off’ of amounts in the directors’
report and financial report. Amounts in the directors’ report and financial report have been rounded off to the nearest dollar
in accordance with the instrument.
This
report is made in accordance with a resolution of directors.
| /s/ Mr. Geoffrey
Kempler |
|
| Mr. Geoffrey Kempler |
|
| Chairman |
|
Melbourne
28
February 2025
Auditor’s
Independence Declaration
As
lead auditor for the review of Alterity Therapeutics Limited for the half-year ended 31 December 2024, I declare that to the best of
my knowledge and belief, there have been:
| (a) | no
contraventions of the auditor independence requirements of the Corporations Act 2001
in relation to the review; and |
| (b) | no
contraventions of any applicable code of professional conduct in relation to the review. |
This
declaration is in respect of Alterity Therapeutics Limited and the entities it controlled during the period.
| /s/
Ben Gargett |
|
| Ben
Gargett |
Melbourne |
Partner
PricewaterhouseCoopers |
28
February 2025 |
PricewaterhouseCoopers,
ABN 52 780 433 757
2
Riverside Quay, SOUTHBANK VIC 3006, GPO Box 1331, MELBOURNE VIC 3001
T:
61 3 8603 1000, F: 61 3 8603 1999, www.pwc.com.au
Liability
limited by a scheme approved under Professional Standards Legislation.
Alterity
Therapeutics Limited
Consolidated statement of profit or loss and other comprehensive income
(Unaudited)
For the half-year ended 31 December 2024
| | |
Notes | | |
31
December
2024
A$ | | |
31
December
2023
A$ | |
| Income | |
| | | |
| | | |
| | |
| Interest
income | |
| 6 | | |
| 111,299 | | |
| 118,400 | |
| Other
income | |
| 6 | | |
| 1,605,925 | | |
| 1,900,724 | |
| | |
| | | |
| | | |
| | |
| Expenses | |
| | | |
| | | |
| | |
| Intellectual
property expenses | |
| | | |
| (63,598 | ) | |
| (96,968 | ) |
| General
and administration expenses | |
| 7 | | |
| (2,984,023 | ) | |
| (2,061,250 | ) |
| Research
and development expenses | |
| 7 | | |
| (5,717,901 | ) | |
| (6,361,034 | ) |
| Other
operating expenses | |
| | | |
| (56,544 | ) | |
| (3,632 | ) |
| Other
gains/(losses) | |
| 7 | | |
| (68,493 | ) | |
| (3,423 | ) |
| Loss
before income tax expense | |
| | | |
| (7,173,335 | ) | |
| (6,507,183 | ) |
| | |
| | | |
| | | |
| | |
| Income
tax expense | |
| | | |
| - | | |
| - | |
| | |
| | | |
| | | |
| | |
| Loss
for the period | |
| | | |
| (7,173,335 | ) | |
| (6,507,183 | ) |
| | |
| | | |
| | | |
| | |
| Other
comprehensive loss | |
| | | |
| | | |
| | |
| Other
comprehensive income for the period, net of tax | |
| | | |
| - | | |
| - | |
| | |
| | | |
| | | |
| | |
| Total
comprehensive loss for the period | |
| | | |
| (7,173,335 | ) | |
| (6,507,183 | ) |
| | |
| | | |
| Cents | | |
| Cents | |
| Loss
per share for profit attributable to the ordinary equity holders of the Group: | |
| | | |
| | | |
| | |
| Basic
loss per share | |
| 5(a) | | |
| (0.14 | ) | |
| (0.26 | ) |
| Diluted
loss per share | |
| 5(a) | | |
| (0.14 | ) | |
| (0.26 | ) |
The
above consolidated statement of profit or loss and other comprehensive income should be read in conjunction with the accompanying notes.
Alterity
Therapeutics Limited
Consolidated statement of financial position
(Unaudited)
As at 31 December 2024
| | |
Notes | |
31
December
2024
A$ | | |
30
June
2024
A$ | |
| ASSETS | |
| |
| | |
| |
| Current
assets | |
| |
| | |
| |
| Cash
and cash equivalents | |
| |
| 4,536,559 | | |
| 12,638,885 | |
| Trade
and other receivables | |
8(a) | |
| 5,684,107 | | |
| 4,041,675 | |
| Other
current assets | |
| |
| 210,516 | | |
| 2,356,300 | |
| Total
current assets | |
| |
| 10,431,182 | | |
| 19,036,860 | |
| | |
| |
| | | |
| | |
| Non-current
assets | |
| |
| | | |
| | |
| Property,
plant and equipment | |
| |
| 15,293 | | |
| 32,154 | |
| Right-of-use
assets | |
| |
| 100,458 | | |
| 154,729 | |
| Total
non-current assets | |
| |
| 115,751 | | |
| 186,883 | |
| | |
| |
| | | |
| | |
| Total
assets | |
| |
| 10,546,933 | | |
| 19,223,743 | |
| | |
| |
| | | |
| | |
| LIABILITIES | |
| |
| | | |
| | |
| Current
liabilities | |
| |
| | | |
| | |
| Trade
and other payables | |
| |
| 2,050,847 | | |
| 4,619,947 | |
| Provisions | |
| |
| 586,949 | | |
| 530,699 | |
| Other
current liabilities | |
| |
| 147 | | |
| 100,000 | |
| Current
lease liabilities | |
| |
| 62,713 | | |
| 107,131 | |
| Income
tax payable | |
| |
| 17,152 | | |
| 15,995 | |
| Total
current liabilities | |
| |
| 2,717,808 | | |
| 5,373,772 | |
| | |
| |
| | | |
| | |
| Non-current
liabilities | |
| |
| | | |
| | |
| | |
| |
| | | |
| | |
| Other
non-current liabilities | |
| |
| 43,118 | | |
| 51,914 | |
| Total
non-current liabilities | |
| |
| 43,118 | | |
| 51,914 | |
| | |
| |
| | | |
| | |
| Total
liabilities | |
| |
| 2,760,926 | | |
| 5,425,686 | |
| | |
| |
| | | |
| | |
| Net
assets | |
| |
| 7,786,007 | | |
| 13,798,057 | |
| | |
| |
| | | |
| | |
| EQUITY | |
| |
| | | |
| | |
| Contributed
equity | |
9(a) | |
| 223,519,553 | | |
| 223,152,985 | |
| Reserves | |
9(c) | |
| 5,274,376 | | |
| 4,806,203 | |
| Accumulated
losses | |
9(b) | |
| (221,007,922 | ) | |
| (214,161,131 | ) |
| | |
| |
| | | |
| | |
| Total
equity | |
| |
| 7,786,007 | | |
| 13,798,057 | |
The
above consolidated statement of financial position should be read in conjunction with the accompanying notes.
Alterity
Therapeutics Limited
Consolidated statement of changes in equity
(Unaudited)
For the half-year ended 31 December 2024
| | |
| |
Attributable
to owners of
Alterity Therapeutics Limited | |
| | |
Notes | |
Contributed
equity
A$ | | |
Reserves
A$ | | |
Accumulated
losses
A$ | | |
Total
A$ | |
| Balance
at 1 July 2023 | |
| |
| 213,971,323 | | |
| 3,972,475 | | |
| (195,130,889 | ) | |
| 22,812,909 | |
| | |
| |
| | | |
| | | |
| | | |
| | |
| Loss
for the period | |
| |
| - | | |
| - | | |
| (6,507,183 | ) | |
| (6,507,183 | ) |
| Total
comprehensive income for the period | |
| |
| - | | |
| - | | |
| (6,507,183 | ) | |
| (6,507,183 | ) |
| | |
| |
| | | |
| | | |
| | | |
| | |
| Transactions
with owners in their capacity as owners: | |
| |
| | | |
| | | |
| | | |
| | |
| Issue
of ordinary shares | |
| |
| 1,268,619 | | |
| - | | |
| - | | |
| 1,268,619 | |
| Share-based
payment expenses | |
| |
| - | | |
| 312,287 | | |
| - | | |
| 312,287 | |
| Transaction
costs | |
| |
| (263,485 | ) | |
| - | | |
| - | | |
| (263,485 | ) |
| Forfeited
options reversed to profit or loss | |
| |
| - | | |
| (7,126 | ) | |
| 7,126 | | |
| - | |
| | |
| |
| 1,005,134 | | |
| 305,161 | | |
| 7,126 | | |
| 1,317,421 | |
| | |
| |
| | | |
| | | |
| | | |
| | |
| Balance
at 31 December 2023 | |
| |
| 214,976,457 | | |
| 4,277,636 | | |
| (201,630,946 | ) | |
| 17,623,147 | |
| | |
| |
| | | |
| | | |
| | | |
| | |
| Balance
at 1 July 2024 | |
| |
| 223,152,985 | | |
| 4,806,203 | | |
| (214,161,131 | ) | |
| 13,798,057 | |
| | |
| |
| | | |
| | | |
| | | |
| | |
| Loss
for the period | |
| |
| - | | |
| - | | |
| (7,173,335 | ) | |
| (7,173,335 | ) |
| Total
comprehensive income for the period | |
| |
| - | | |
| - | | |
| (7,173,335 | ) | |
| (7,173,335 | ) |
| | |
| |
| | | |
| | | |
| | | |
| | |
| Transactions
with owners in their capacity as owners: | |
| |
| | | |
| | | |
| | | |
| | |
| Issue
of ordinary shares | |
9(a) | |
| 398,645 | | |
| - | | |
| - | | |
| 398,645 | |
| Share-based
payment expenses | |
9(c)(i) | |
| - | | |
| 794,717 | | |
| - | | |
| 794,717 | |
| Transaction
costs | |
9(a) | |
| (32,077 | ) | |
| - | | |
| - | | |
| (32,077 | ) |
| Forfeited
options reversed to profit or loss | |
| |
| - | | |
| (326,544 | ) | |
| 326,544 | | |
| - | |
| | |
| |
| 366,568 | | |
| 468,173 | | |
| 326,544 | | |
| 1,161,285 | |
| | |
| |
| | | |
| | | |
| | | |
| | |
| Balance
at 31 December 2024 | |
| |
| 223,519,553 | | |
| 5,274,376 | | |
| (221,007,922 | ) | |
| 7,786,007 | |
The
above consolidated statement of changes in equity should be read in conjunction with the accompanying notes.
Alterity
Therapeutics Limited
Consolidated statement of cash flows
(Unaudited)
For the half-year ended 31 December 2024
| | |
Notes | |
31
December
2024
A$ | | |
31
December
2023
A$ | |
| Cash
flows from operating activities | |
| |
| | | |
| | |
| Payments
to suppliers and employees | |
| |
| (8,470,921 | ) | |
| (9,268,626 | ) |
| Interest
received | |
| |
| 111,299 | | |
| 98,966 | |
| R&D
tax incentive refund | |
| |
| - | | |
| 4,678,828 | |
| Interest
paid | |
| |
| - | | |
| (4,108 | ) |
| Net
cash (outflow) from operating activities | |
10 | |
| (8,359,622 | ) | |
| (4,494,940 | ) |
| | |
| |
| | | |
| | |
| Cash
flows from investing activities | |
| |
| | | |
| | |
| Payments
for property, plant and equipment | |
| |
| - | | |
| (5,722 | ) |
| Net
cash (outflow) from investing activities | |
| |
| - | | |
| (5,722 | ) |
| | |
| |
| | | |
| | |
| Cash
flows from financing activities | |
| |
| | | |
| | |
| Proceeds
from issues of shares and other equity securities | |
| |
| 398,645 | | |
| 1,368,619 | |
| Transaction
costs relating to issue of equity | |
| |
| (32,077 | ) | |
| (263,485 | ) |
| Principle
elements of lease payments | |
| |
| (68,249 | ) | |
| (54,787 | ) |
| Net
cash inflow from financing activities | |
| |
| 298,319 | | |
| 1,050,347 | |
| | |
| |
| | | |
| | |
| Net
(decrease) in cash and cash equivalents | |
| |
| (8,061,303 | ) | |
| (3,450,315 | ) |
| Cash
and cash equivalents at the beginning of the period | |
| |
| 12,638,885 | | |
| 15,773,783 | |
| Effects
of exchange rate changes on cash and cash equivalents | |
| |
| (41,023 | ) | |
| (3,042 | ) |
| Cash
and cash equivalents at end of period | |
| |
| 4,536,559 | | |
| 12,320,426 | |
The
above consolidated statement of cash flows should be read in conjunction with the accompanying notes.
Alterity
Therapeutics Limited
Notes to the consolidated financial statements
(Unaudited)
31 December 2024
1
Basis of preparation of half-year report
This
condensed consolidated interim report for the half-year reporting period ended 31 December 2024 has been prepared in accordance with
Accounting Standard AASB 134 Interim Financial Reporting and the Corporations Act 2001. These financial statements also
comply with International Financial Reporting Standards (“IFRS”) as issued by the International Accounting Standards Board
(“IASB”), as applicable to interim financial reporting.
This
condensed consolidated interim financial report does not include all the notes of the type normally included in an annual financial report.
Accordingly, this report is to be read in conjunction with the annual report for the year ended 30 June 2024 and any public announcements
made by Alterity Therapeutics Limited (the “Group”) during the interim reporting period in accordance with the continuous
disclosure requirements of the Corporations Act 2001.
The
accounting policies adopted are consistent with those of the previous financial year and corresponding interim reporting period except
as discussed below.
(a)
New and amended standards adopted by the Group
The
Group has adopted all of the new or amended Accounting Standards and Interpretations issued by the Australian Accounting Standards Board
‘AASB’ that are mandatory for the current reporting period.
The
adoption of these standards has not had any impact on the disclosures or amounts reported in these financial statements.
2
Significant changes in the current reporting period
There
have been no significant changes in the state of affairs of the Company during the period.
3
Segment information
Operating
segments are reported in a manner consistent with the internal reporting provided to the chief operating decision maker. The chief operating
decision maker, who is responsible for allocating resources and assessing performance of the operating segments, has been identified
as the Chief Executive Officer of Alterity Therapeutics Limited. For the current and previous reporting periods, the Group operated in
one segment, being research and development in the field of Parkinsonian and other neurodegenerative disorders.
4
Dividends
The
Group has not declared any dividends in the period ended 31 December 2024 (2023: nil)
Alterity
Therapeutics Limited
Notes to the consolidated financial statements
(Unaudited)
31 December 2024
(continued)
5
Loss per share
(a)
Basic and diluted loss per share
| | |
31
December | | |
31
December | |
| | |
2024
Cents | | |
2023
Cents | |
| Loss
per share for profit attributable to the ordinary equity holders of the Group: | |
| | | |
| | |
| Basic
loss per share | |
| (0.14 | ) | |
| (0.26 | ) |
| Diluted
loss per share | |
| (0.14 | ) | |
| (0.26 | ) |
(b)
Reconciliation of loss used in calculating loss per share
| | |
| 31
December | | |
| 31
December | |
| | |
| 2024
A$ | | |
| 2023
A$ | |
| Basic
loss per share | |
| | | |
| | |
| Loss
attributable to the ordinary equity holders of the company used in calculating basic loss per share: | |
| (7,173,335 | ) | |
| (6,507,183 | ) |
| | |
| | | |
| | |
| Diluted
loss per share | |
| | | |
| | |
| Loss
attributable to the ordinary equity holders of the company used in calculating diluted loss per share: | |
| (7,173,335 | ) | |
| (6,507,183 | ) |
Alterity
Therapeutics Limited
Notes to the consolidated financial statements
(Unaudited)
31 December 2024
(continued)
5
Loss per share (continued)
(c)
Weighted average number of shares used as the denominator
| | |
31
December | | |
31
December | |
| | |
2024
A$ | | |
2023
A$ | |
| Weighted
average number of ordinary shares used as the denominator in Calculating basic and diluted loss per share: | |
| 5,313,423,936 | | |
| 2,503,279,085 | |
Options
that are considered to be potential ordinary shares are excluded from the weighted average number of ordinary shares used in the calculation
of basic loss per share. Where dilutive, potential ordinary shares are included in the calculation of diluted loss per share. All the
options on issue do not have the effect to dilute the loss per share. Therefore, they have been excluded from the calculation of diluted
loss per share.
6
Interest and other income
| | |
31
December | | |
31
December | |
| | |
2024 | | |
2023 | |
| | |
A$ | | |
A$ | |
| Interest
and other income | |
| | | |
| | |
| Interest
income | |
| 111,299 | | |
| 118,400 | |
| | |
| 111,299 | | |
| 118,400 | |
| Other
Income | |
| | | |
| | |
| R&D
tax incentive | |
| 1,605,925 | | |
| 1,900,724 | |
| | |
| 1,605,925 | | |
| 1,900,724 | |
Alterity
Therapeutics Limited
Notes to the consolidated financial statements
(Unaudited)
31 December 2024
(continued)
7
Loss for the period
| | |
31
December | | |
31
December | |
| | |
2024
A$ | | |
2023
A$ | |
| Loss
before income tax has been determined after: | |
| | | |
| | |
| | |
| | | |
| | |
| General
and administration expenses | |
| | | |
| | |
| Depreciation
on fixed assets | |
| 16,862 | | |
| 18,355 | |
| Depreciation
on leased assets | |
| 55,727 | | |
| 55,562 | |
| Employee
expenses (non R&D related) | |
| 537,703 | | |
| 354,066 | |
| Consultant
and director expenses | |
| 225,006 | | |
| 160,501 | |
| Audit,
internal control and other assurance expenses | |
| 184,954 | | |
| 52,678 | |
| Corporate
compliance expenses | |
| 450,379 | | |
| 193,733 | |
| Office
rental | |
| 9,654 | | |
| (4,669 | ) |
| Other
administrative and office expenses | |
| 272,569 | | |
| 459,281 | |
| Insurance
expenses | |
| 266,951 | | |
| 358,056 | |
| Share-based
payment expenses | |
| 794,717 | | |
| 312,287 | |
| Corporate
advisory | |
| 169,501 | | |
| 101,400 | |
| | |
| 2,984,023 | | |
| 2,061,250 | |
| Research
and development expenses | |
| | | |
| | |
| Employee
expenses | |
| 1,144,157 | | |
| 1,168,596 | |
| Other
research and development expenses1 | |
| 4,637,342 | | |
| 5,192,438 | |
| | |
| 5,781,499 | | |
| 6,361,034 | |
| | |
| | | |
| | |
| Other
gains and losses | |
| | | |
| | |
| Forfeited
options from reserves | |
| 326,544 | | |
| - | |
| Foreign
exchange (gain)/loss | |
| (258,051 | ) | |
| 3,423 | |
| | |
| 68,493 | | |
| 3,423 | |
| (1) | Other
research and development expenses mainly consist of expenses paid for contracted research
and development activities conducted by third parties on behalf of the Group and intellectual
property expenses. |
Alterity
Therapeutics Limited
Notes to the consolidated financial statements
(Unaudited)
31 December 2024
(continued)
8
Financial assets and financial liabilities
(a)
Trade and other receivables
| | |
| | |
31
December | | |
| | |
| | |
30
June | | |
| |
| | |
| | |
2024 | | |
| | |
| | |
2024 | | |
| |
| | |
| | |
Non- | | |
| | |
| | |
Non- | | |
| |
| | |
Current | | |
current | | |
Total | | |
Current | | |
current | | |
Total | |
| | |
A$ | | |
A$ | | |
A$ | | |
A$ | | |
A$ | | |
A$ | |
| | |
| | | |
| | | |
| | | |
| | | |
| | | |
| | |
| R&D
tax incentive receivable | |
| 5,625,211 | | |
| - | | |
| 5,625,211 | | |
| 4,019,286 | | |
| - | | |
| 4,019,286 | |
| Accrued
interest income | |
| - | | |
| - | | |
| - | | |
| 157 | | |
| - | | |
| 157 | |
| Goods
and services tax receivable | |
| 58,896 | | |
| - | | |
| 58,896 | | |
| 22,232 | | |
| - | | |
| 22,232 | |
| Other
receivable | |
| - | | |
| - | | |
| - | | |
| - | | |
| - | | |
| - | |
| | |
| 5,684,107 | | |
| - | | |
| 5,684,107 | | |
| 4,041,675 | | |
| - | | |
| 4,041,675 | |
R&D
tax incentive receivable represents the amount of R&D tax incentive the Group expects to recover.
A
43.5% R&D Tax incentive refundable tax offset is available to eligible small companies with an annual aggregate turnover of less
than $20 million. For the half-year ended 31 December 2024, the Group recorded $1,605,925 and $5,625,211 respectively in other income
and receivables.
(i)
Classification as trade and other receivables
Trade
receivables and other receivables are non-derivative financial assets with fixed or determinable payments that are not quoted in an active
market. If collection of the amounts is expected in one year or less they are classified as current assets. If not, they are presented
as non-current assets. Trade and other receivables are generally due for settlement within one year and therefore are all classified
as current.
Alterity
Therapeutics Limited
Notes to the consolidated financial statements
(Unaudited)
31 December 2024
(continued)
9
Equity
(a)
Contributed equity
| | |
31
December | | |
30
June | | |
31
December | | |
30
June | |
| | |
2024
Shares | | |
2024
Shares | | |
2024
A$ | | |
2024
A$ | |
| | |
| | |
| | |
| | |
| |
| Ordinary
shares - fully paid | |
| 5,320,336,118 | | |
| 5,245,115,318 | | |
| 223,527,101 | | |
| 223,152,985 | |
Movements
in ordinary share:
| Details | |
Number
of shares | | |
A$ | |
| Opening
balance 1 July 2024 | |
| 5,245,115,318 | | |
| 223,152,985 | |
| Shares
issued during the year | |
| 75,220,800 | | |
| 406,193 | |
| Transaction
costs | |
| - | | |
| (32,077 | ) |
| Balance
31 December 2024 | |
| 5,320,336,118 | | |
| 223,527,101 | |
Details
of shares issued during the current period:
| |
| | |
Issue
price | | |
Amount | |
| Details | |
Number | | |
A$ | | |
A$ | |
| | |
| | | |
| | | |
| | |
| 18-Jul-2024
Issue of ordinary fully paid shares | |
| 75,220,800 | | |
| 0.0054 | | |
| 398,645 | |
| | |
| 75,220,800 | | |
| | | |
| 389,645 | |
(b)
Accumulated losses
Movements
in accumulated losses were as follows:
| | |
31
December | | |
31
December | |
| | |
2024 | | |
2023 | |
| | |
A$ | | |
A$ | |
| | |
| | |
| |
| Balance
at the beginning of the period | |
| 214,161,131 | | |
| 195,130,889 | |
| Net
loss for the period | |
| 7,173,335 | | |
| 6,507,183 | |
| Reclassify
expired/lapsed options from reserves | |
| (326,544 | ) | |
| (7,126 | ) |
| Balance
at the end of the period | |
| 221,007,922 | | |
| 201,630,946 | |
(c)
Reserves
| | |
31
December | | |
30
June | | |
31
December | | |
30
June | |
| | |
2024
Options | | |
2024
Options | | |
2024
A$ | | |
2024
A$ | |
| | |
| | | |
| | | |
| | | |
| | |
| Options
over fully paid ordinary shares | |
| 1,472,249,388 | | |
| 3,250,009,092 | | |
| 5,274,376 | | |
| 4,806,203 | |
Alterity
Therapeutics Limited
Notes to the consolidated financial statements
(Unaudited)
31 December 2024
(continued)
9
Equity (continued)
Reserves
(continued)
(i)
Options (continued)
The
table below presents the movements in options granted and issued during the half-year ended 31 December 2024.
| | |
| | |
Amount | |
| Details | |
Number | | |
A$ | |
| |
| |
| | | |
| | |
| 31-Jul-2024 |
Unlisted
options expired | |
| (12,000,000 | ) | |
| (326,544 | ) |
| 31-Aug-2024 |
Free
attaching unlisted options expired | |
| (1,935,759,704 | ) | |
| - | |
| 30-Dec-2024 |
Unlisted
options issued under ESOP | |
| 170,000,000 | | |
| 466,855 | |
|
Share-based
payment expense | |
| | | |
| 327,862 | |
| | |
| (1,777,759,704 | ) | |
| 468,173 | |
| * | Rounded
to the nearest four decimal points. |
(ii)
Free-attaching options
| | |
31
December | | |
30
June | | |
31
December | | |
30
June | |
| | |
2024
Options | | |
2024
Options | | |
2024
A$ | | |
2024
A$ | |
| | |
| | | |
| | | |
| | | |
| | |
| Free-attaching
options | |
| - | | |
| 1,935,759,704 | | |
| - | | |
| - | |
On
31 August 2024, the 1,935,759,704 free attaching short-dated options with an exercise price of A$0.07 expired. There was no further movement
during the half-year ended 31 December 2024.
There
have been no other options over fully paid ordinary shares issued, exercised or forfeited during the current period.
(iii)
Nature and purpose of reserves
The
share-based payments reserve is used to recognise the fair value of options issued to employees and consultants but not exercised.
Alterity
Therapeutics Limited
Notes to the consolidated financial statements
(Unaudited)
31 December 2024
(continued)
10
Reconciliation of profit after income tax to net cash flow from operating activities
| | |
31
December | | |
31
December | |
| | |
| 2024 A$ | | |
| 2023
A$ | |
| | |
| | | |
| | |
| Loss
for the period | |
| 7,173,335 | | |
| 6,507,183 | |
| Depreciation
on fixed assets | |
| (16,862 | ) | |
| (18,355 | ) |
| Depreciation
on leased assets | |
| (55,727 | ) | |
| (55,562 | ) |
| Non-cash
employee benefits expense - share-based payments | |
| (794,717 | ) | |
| (312,287 | ) |
| Net
foreign exchange differences | |
| 44,095 | | |
| (4,227 | ) |
| Increase
in provisions | |
| (56,250 | ) | |
| 93,478 | |
| Decrease/(increase)
in trade and other receivables | |
| 1,642,432 | | |
| (2,681,459 | ) |
| (Increase)/decrease
in other current assets | |
| (2,145,784 | ) | |
| 1,079,100 | |
| Increase/(decrease)
in trade and other payables | |
| 2,569,100 | | |
| (112,931 | ) |
| | |
| 8,359,622 | | |
| 4,494,940 | |
11
Related party transactions
During
the half-year ended 31 December 2024 the Group paid a total of A$54,331 (excl. GST) in corporate advisory fees to Kemdev Pty Ltd, an
associated entity of Mr. Geoffrey Kempler.
There
were no other related party transactions other than those related to director and key management personnel remuneration and equity and
transactions by the Group and its subsidiaries.
12
Events occurring after the reporting period
The
following occurred after the Balance Date:
The
Catalent case settled in January 2025, with US$674k received on 14 February 2025.
On
22 January 2025, 95,238 ordinary fully paid shares were issued, following conversion of ATHO listed options with an exercise price of
$0.01 each and expiry date of 31 August 2026.
On
30 January 2025, 6,333,333 ordinary fully paid shares were issued following conversion of unlisted options with an exercise price of
$0.004 each and expiry date of 13 March 2029.
On
30 January 2025, Alterity announced positive topline results from its ATH434-201 Phase 2 clinical trial. The data demonstrated a clinically
meaningful benefit at both ATH434 doses studied, and the trial achieved statistical significance at the 50 mg dose with 48% slowing of
clinical progression on the UMSARS I. In addition, ATH434 demonstrated a favourable safety profile and key MRI biomarker data showed
iron stabilisation in MSA affected brain regions. Based on the strength of these Phase 2 data, the company plans to engage with the FDA
to discuss the path forward for accelerating the development of ATH434.
On
4 February 2025, 164,242,200 ordinary fully paid shares were issued at $0.0129 each under Placement per Appendix 3B issued 3 February
2025.
On
17 February 2025, 1,165,841,830 ordinary fully paid shares were issued at $0.011 each under Placement per Appendix 3B issued 10 February
2025.
On
10 February 2025, the company released an announcement that it had received binding commitments for a capital raising of A$40 million
via a two tranche placement of 3,636,363,636 fully paid ordinary shares, at A$0.011 per share.
Tranche
One was completed on 17 February 2025, with the issue of 1,165,841,830 ordinary fully paid shares with an exercise price of $0.011, to
raise A$12.8 million before costs.
Tranche
Two, the issue of 2,470,521,806 ordinary fully paid shares with an exercise price of $0.011 to raise A$27.2 million before costs,is subject
to shareholder approval.
Alterity
Therapeutics Limited
Notes to the consolidated financial statements
(Unaudited)
31 December 2024
(continued)
12
Events occurring after the reporting period (continued)
For
every 3 new shares issued in both Tranche One and Tranche Two, 1 free attaching option will be issued. The issue of the new options is
subject to shareholder approval.
New
shares issued under Tranche Two and the issue of the new options are conditional on shareholder approval to be sought at an Extraordinary
General Meeting of the Company which is expected to be held in late March 2025.
Apart
from the issuance of ordinary shares and options, no further matters or circumstances has arisen since 31 December 2024 that has significantly
affected the Group’s operations, results or state of affairs, or may do so in future years.
13
Significant estimates and assumptions
Estimates
and judgements are continually evaluated and are based on historical experience and other factors, including expectations of future events
that may have a financial impact on the entity and that are believed to be reasonable under the circumstances.
The
Company and its two wholly-owned subsidiaries (the “Group”) makes estimates and assumptions concerning the future. The resulting
accounting estimates will, by definition, seldom equal the related actual results. The estimates and assumptions that have a significant
risk of causing a material adjustment to the carrying amounts of assets and liabilities within the next financial period are discussed
below.
The
accounting policies adopted are consistent with those of the previous financial year and corresponding interim reporting period.
(a)
Funding position of the Group
The
Group has incurred recurring losses since inception, including an operating loss of $7,173,335 for the half year ended 31 December 2024
(half year ended 31 December 2023: $6,507,183) and an operating cash outflow of $8,359,622 for the half year ended 31 December 2024 (half
year ended 31 December 2023: $4,494,940).
The
Group expects to continue incurring losses into the foreseeable future and will need to raise additional capital in the future to continue
the long-term development of its planned research and development programs. Cash and cash equivalents on hand as at 31 December 2024
was $4,536,559.
Subsequent
to the reporting period, the Group received binding commitments for a capital raise of approx. $40 million via a two tranche placement.
Of this, $12.8 million, net of costs was received in mid-February 2025, with the second tranche of approx. $27.2 million subject to shareholder
approval at a shareholder’s meeting scheduled in March 2025. This new capital will enable further progression of the Group’s
planned research and development programs and in particular to accelerate lead compound ATH434’s regulatory and clinical development.
The funds received provide sufficient cash on hand to fulfil planned expenditure over the coming year.
As
a result, the Directors have prepared the consolidated financial statements on a going concern basis, which contemplates the realisation
of assets and the satisfaction of its liabilities in the normal course of business.
Alterity
Therapeutics Limited
Directors’ declaration
31 December 2024
In
the directors’ opinion:
| (a) | the
interim financial statements and notes set out on pages 7 to 19 are in accordance with the
Corporations Act 2001, including: |
| (i) | complying
with Accounting Standards, the Corporations Regulations 2001 and other mandatory professional
reporting requirements, and |
| (ii) | giving
a true and fair view of the consolidated entity’s financial position as at 31 December
2024 and of its performance for the half-year ended on that date, and |
| (b) | there
are reasonable grounds to believe that Alterity Therapeutics Limited will be able to pay
its debts as and when they become due and payable. |
This
declaration is made in accordance with a resolution of directors.
| /s/ Mr. Geoffrey
Kempler |
|
| Mr. Geoffrey Kempler |
|
| Chairman |
|
Melbourne
28
February 2025
Preparation
of interim financial statements for users in multiple jurisdictions
The
Group has prepared the interim financial statements to conform to the requirements and needs of users of the financial statements located
in both Australia and the U.S.
For
U.S users, the Group has prepared the interim financial statements to conform to the requirements of IAS 34 Interim Financial Reporting.
Consistent with U.S. domestic registrants, the Group has labelled the interim financial information “unaudited” because the
interim financial information is not subject to an audit by our independent registered public accounting firm. The auditor’s independence
declaration and independent auditor’s review report are included within this filing to meet the requirements of Australian laws
and regulations and are furnished, not filed, for the purposes of incorporation of the related financial statements in any U.S. registration
document.
For
Australian users, the Group has prepared the interim financial statements to conform to the requirements of the Corporations Act 2001
and AASB 134 Interim Financial Reporting. A review of the interim financial information has been performed by the Group’s independent
auditors to meet the requirements of Australian Auditing Standard on Review Engagements ASRE 2410 Review of a Financial Report Performed
by the Independent Auditor of the Entity and users should refer to the auditor’s independence declaration and independent auditor’s
review report included within this filing.
Independent
auditor’s review report to the members of Alterity Therapeutics Limited
Report
on the half-year financial report
Conclusion
We
have reviewed the half-year financial report of Alterity Therapeutics Limited (the Company) and the entities it controlled during the
half-year (together the Group), which comprises the consolidated statement of financial position as at 31 December 2024, the consolidated
statement of profit or loss and other comprehensive income, consolidated statement of changes in equity and the consolidated statement
of cash flows for the half-year ended on that date, selected explanatory notes and the directors’ declaration.
Based
on our review, which is not an audit, we have not become aware of any matter that makes us believe that the accompanying half-year financial
report of Alterity Therapeutics Limited does not comply with the Corporations Act 2001 including:
| 1. | giving
a true and fair view of the Group’s financial position as at 31 December 2024 and of
its performance for the half-year ended on that date |
| 2. | complying
with Accounting Standard AASB 134 Interim Financial Reporting and the Corporations
Regulations 2001. |
Basis
for conclusion
We
conducted our review in accordance with ASRE 2410 Review of a Financial Report Performed by the Independent Auditor of the Entity
(ASRE 2410). Our responsibilities are further described in the Auditor’s responsibilities for the review of the half-year
financial report section of our report.
We
are independent of the Group in accordance with the auditor independence requirements of the Corporations Act 2001 and the ethical
requirements of the Accounting Professional & Ethical Standards Board’s APES 110 Code of Ethics for Professional Accountants
(including Independence Standards) (the Code) that are relevant to the audit of the annual financial report in Australia. We have
also fulfilled our other ethical responsibilities in accordance with the Code.
Responsibilities
of the directors for the half-year financial report
The
directors of the Company are responsible for the preparation of the half-year financial report, in accordance with Australian Accounting
Standards and the Corporations Act 2001, including giving a true and fair view, and for such internal control as the directors
determine is necessary to enable the preparation of the half-year financial report that is free from material misstatement whether due
to fraud or error.
PricewaterhouseCoopers,
ABN 52 780 433 757
2
Riverside Quay, SOUTHBANK VIC 3006, GPO Box 1331, MELBOURNE VIC 3001
T:
61 3 8603 1000, F: 61 3 8603 1999, www.pwc.com.au
Liability
limited by a scheme approved under Professional Standards Legislation.
Auditor’s
responsibilities for the review of the half-year financial report
Our
responsibility is to express a conclusion on the half-year financial report based on our review. ASRE 2410 requires us to conclude whether
we have become aware of any matter that makes us believe that the half-year financial report is not in accordance with the Corporations
Act 2001 including giving a true and fair view of the Group’s financial position as at 31 December 2024 and of its performance
for the half-year ended on that date, and complying with Accounting Standard AASB 134 Interim Financial Reporting and the Corporations
Regulations 2001.
A
review of a half-year financial report consists of making enquiries, primarily of persons responsible for financial and accounting matters,
and applying analytical and other review procedures. A review is substantially less in scope than an audit conducted in accordance with
Australian Auditing Standards and consequently does not enable us to obtain assurance that we would become aware of all significant matters
that might be identified in an audit. Accordingly, we do not express an audit opinion.
PricewaterhouseCoopers
| /s/
Ben Gargett |
|
| Ben
Gargett |
Melbourne |
| Partner |
28
February 2025 |
Alterity Therapeutics (PK) (USOTC:PRNAF)
Graphique Historique de l'Action
De Fév 2025 à Mar 2025
Alterity Therapeutics (PK) (USOTC:PRNAF)
Graphique Historique de l'Action
De Mar 2024 à Mar 2025
